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Interleukin 15

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https://www.readbyqxmd.com/read/28433997/argon-delays-initiation-of-liver-regeneration-after-partial-hepatectomy-in-rats
#1
Tom Florian Ulmer, Athanassious Fragoulis, Henriette Dohmeier, Andreas Kroh, Anne Andert, Christian Stoppe, Hamid Alizai, Christian Klink, Mark Coburn, Ulf Peter Neumann
BACKGROUND: The liver can heal up to restitutio ad integrum following damage resulting from various causes. Different studies have demonstrated the protective effect of argon on various cells and organs. To the best of our knowledge, the organ-protective effects of the noble gas argon on the liver have not yet been investigated, although argon appears to influence signal paths that are well-known mediators of liver regeneration. We hypothesized that argon inhalation prior to partial hepatectomy (70%) has a positive effect on the initiation of liver regeneration in rats...
April 22, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28433068/the-role-of-interleukin-1%C3%AE-and-extracellular-signal-regulated-kinase-1-2-in-glucose-stimulated-insulin-secretion
#2
Ben Niu, Heng Su, Xue-Shan Xia, Qiu He, Yuan-Ming Xue, Xin-Ming Yan
Glucose-stimulated insulin secretion (GSIS) is one of the important physiological characteristics of islet β cells, and extracellular-regulated protein kinase 1/2 (ERK1/2) is an important member of the mitogen-activated protein kinase family that regulates this process. The inflammatory cytokine interleukin (IL)-1β can inhibit the insulin secretion of pancreatic β cells, but the exact mechanism is unclear. This study was designed to investigate the inhibitory effect of IL-1β on GSIS in βTC-6 cells and its relation with the ERK1/2 signal transduction pathway...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28430124/association-between-serum-selenium-concentrations-and-levels-of-proinflammatory-and-profibrotic-cytokines-interleukin-6-and-growth-differentiation-factor-15-in-patients-with-alcoholic-liver-cirrhosis
#3
Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Anna Błażewicz, Jarosław Niedziałek, Grzegorz Mizerski, Mariusz Jojczuk, Andrzej Ochal, Jarosław J Sak, Wojciech Załuska
According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines-interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria...
April 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28429895/interleukin-6-and-resistin-in-relation-to-anthropometric-measurements-in-school-children
#4
Carolina Del Pilar Escalona-Villasmil, Jorymar Yoselyn Leal-Montiel, Pablo Antonio Ortega-Fernindez, Carlos Javier Chavez
The worldwide prevalence of childhood obesity has increased greatly over the past three decades. The increasing occurrence in children of disorders, such as type 2 diabetes, is believed to be a consequence of this obesity epidemic. Although the precise mechanisms are still unclear, dysregulated production or secretion of adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related me- tabolic diseases. The objective of the study was to determine the serum levels of interleukin-6 and resistin in relation to anthropometric measurements in school children...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28429138/prothrombotic-state-in-asthma-is-related-to-increased-levels-of-inflammatory-cytokines-il-6-and-tnf%C3%AE-in-peripheral-blood
#5
Stanislawa Bazan-Socha, Lucyna Mastalerz, Agnieszka Cybulska, Lech Zareba, Romy Kremers, Michal Zabczyk, Grazyna Pulka, Teresa Iwaniec, Coenraad Hemker, Anetta Undas
Recently, we have reported that asthma is associated with enhanced plasma thrombin formation and impaired fibrinolysis. The mechanisms underlying the prothrombotic state in this disease are unknown. Our aim was to investigate whether prothrombotic alterations in asthmatics are associated with inflammation. We studied 164 adult, white, stable asthmatics and 72 controls matched for age, sex, body mass index (BMI), and smoking. Plasma tumor necrosis factor α (TNFα), interleukin (IL)-6, and serum periostin were evaluated using ELISAs, and their associations with thrombin generation, fibrinolytic capacity, expressed as clot lysis time (CLT), and platelet markers were later analyzed...
April 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28424683/novel-strategy-to-expand-super-charged-nk-cells-with-significant-potential-to-lyse-and-differentiate-cancer-stem-cells-differences-in-nk-expansion-and-function-between-healthy-and-cancer-patients
#6
Kawaljit Kaur, Jessica Cook, So-Hyun Park, Paytsar Topchyan, Anna Kozlowska, Nick Ohanian, Changge Fang, Ichiro Nishimura, Anahid Jewett
Natural killer (NK) cells are known to target cancer stem cells and undifferentiated tumors. In this paper, we provide a novel strategy for expanding large numbers of super-charged NK cells with significant potential to lyse and differentiate cancer stem cells and demonstrate the differences in the dynamics of NK cell expansion between healthy donors and cancer patients. Decline in cytotoxicity and lower interferon (IFN)-γ secretion by osteoclast (OC)-expanded NK cells from cancer patients correlates with faster expansion of residual contaminating T cells within purified NK cells, whereas healthy donors' OCs continue expanding super-charged NK cells while limiting T cell expansion for up to 60 days...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28420473/-the-study-of-serum-complements-and-proinflammatory-cytokines-in-sepsis-rats
#7
Ping Sun, Dongqiang Wang, Chunlei Zhou, Zhiqin Tang, Wei Liu, Hong Mu
OBJECTIVE: To observe the changes of serum complements and proinflammatory cytokines in rats with sepsis, and to explore the possible mechanism. METHODS: 120 healthy male Wistar rats were randomly divided into three groups: normal control group (n = 15), sham operation group (n = 15) and sepsis group [cecum ligation and puncture (CLP) operation, n = 90]. The sepsis rats were sacrificed on 24, 48 and 72 hours after modeling. The level of serum complements (C5, C5a) and cytokines tumor necrosis factor-α (TNF-α), interleukin (IL-1, IL-6), high mobility group box 1 (HMGB1), macrophage migration inhibitory factor (MIF) were detected by enzyme linked immunosorbent assay (ELISA)...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28420468/-effect-of-heparin-pretreatment-on-the-level-of-neutrophil-extracellular-traps-of-serum-and-lung-tissue-in-septic-mice
#8
Jing Jiang, Shengtian Mu, Fangxiao Zhang, Yanting Qiao, Yongran Wu, Zhidan Zhang, Xiaochun Ma
OBJECTIVE: To investigate the influence of heparin pretreatment on serum and lung tissue level of neutrophil extracellular traps (NETs) in septic mice model and its molecular mechanism. METHODS: Ninety male C57BL/6J mice were randomly divided into control group (n = 30), lipopolysaccharides (LPS) group (n = 30, 30 mg/kg LPS in 100 ?L normal saline was intraperitoneally injected) and LPS+heparin group (n = 30, 8 U of heparin in 20 ?L normal saline was subcutaneously injected 30 minutes before the injection of LPS)...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28420462/-differential-expression-profile-of-long-non-coding-rna-in-the-lipopolysaecharide-induced-inflammation-of-monocyte-derived-macrophages
#9
Zhen Deng, Fangyi Yao, Jianqing Ye, Jianqing Xu, Cheng Qing, Qing Luo, Zikun Huang
OBJECTIVE: To analyze the expression profile of long non-coding RNA (lncRNA) in the lipopolysaecharide (LPS)-induced inflammation of monocyte-derived macrophages. METHODS: Peripheral blood mononuclear cells were derived from healthy donor and induced into macrophages. The macrophages were divided into blank control group and LPS (1 mg/L) stimulated 12 hours group. Culture supernatants and cell pellets were harvested in each group, enzyme linked immunosorbent assay (ELISA) was used to assay the production changes of interleukins (IL-1β and IL-6), and tumor necrosis factor-α (TNF-α) in the supernatant...
April 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28420140/oleuropein-decreases-cyclooxygenase-2-and-interleukin-17-expression-and-attenuates-inflammatory-damage-in-colonic-samples-from-ulcerative-colitis-patients
#10
Tiziana Larussa, Manuela Oliverio, Evelina Suraci, Marta Greco, Roberta Placida, Serena Gervasi, Raffaella Marasco, Maria Imeneo, Donatella Paolino, Luigi Tucci, Elio Gulletta, Massimo Fresta, Antonio Procopio, Francesco Luzza
Oleuropein (OLE) is the major phenolic secoiridoid of olive tree leaves, and its antioxidant and anti-inflammatory activities have been demonstrated in in vitro and in vivo animal models. The aim of this study was to investigate the activity of OLE in the colonic mucosa from patients with ulcerative colitis (UC). Biopsies obtained during colonoscopy from 14 patients with active UC were immediately placed in an organ culture chamber and challenged with lipopolysaccharide from Escherichia coli (EC-LPS) at 1 μg/mL in the presence or absence of 3 mM OLE...
April 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#11
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28417544/urine-biomarkers-of-acute-kidney-injury-in-noncritically-ill-hospitalized-children-treated-with-chemotherapy
#12
Maya Sterling, Zubaida Al-Ismaili, Kelly R McMahon, Melissa Piccioni, Michael Pizzi, Theresa Mottes, Larry C Lands, Sharon Abish, Adam J Fleming, Michael R Bennett, Ana Palijan, Prasad Devarajan, Stuart L Goldstein, Maureen M O'Brien, Michael Zappitelli
BACKGROUND: Cisplatin (Cis), carboplatin (Carb), and ifosfamide (Ifos) are common nephrotoxic chemotherapies. Biomarkers of tubular injury may allow for early acute kidney injury (AKI) diagnosis. PROCEDURE: We performed a two-center (Canada, United States) pilot study to prospectively measure serum creatinine (SCr), urine neutrophil gelatinase-associated lipocalin (NGAL), and interleukin-18 (IL-18) in children receiving Cis/Carb (27 episodes), Ifos (30 episodes), and in 15 hospitalized, nonchemotherapy patients...
April 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28413686/cytokine-profiles-of-amyopathic-dermatomyositis-with-interstitial-lung-diseases-treated-with-mycophenolate
#13
Masachika Hayashi, Ami Aoki, Katsuaki Asakawa, Takuro Sakagami, Toshiaki Kikuchi, Toshinori Takada
A 59-year-old Japanese man diagnosed with interstitial lung disease associated with amyopathic dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA-5) antibodies was treated with intravenous methyl prednisolone (PSL) 1000 mg, oral PSL 1 mg/kg, and oral cyclosporin 200 mg daily. His respiratory condition worsened after treatment with two times of intravenous cyclophosphamide and another steroid pulse therapy as well as PSL and cyclosporin. Addition of mycophenolate mofetil (MMF), 1...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28413023/a-chemoattractant-guided-walk-through-lymphopoiesis-from-hematopoietic-stem-cells-to-mature-b-lymphocytes
#14
Vivian Y Lim, Sandra Zehentmeier, Chris Fistonich, João P Pereira
B lymphocytes develop from hematopoietic stem cells (HSCs) in specialized bone marrow niches composed of rare mesenchymal lineage stem/progenitor cells (MSPCs) and sinusoidal endothelial cells. These niches are defined by function and location: MSPCs are mostly perisinusoidal cells that together with a small subset of sinusoidal endothelial cells express stem cell factor, interleukin-7 (IL-7), IL-15, and the highest amounts of CXCL12 in bone marrow. Though rare, MSPCs are morphologically heterogeneous, highly reticular, and form a vast cellular network in the bone marrow parenchyma capable of interacting with large numbers of hematopoietic cells...
2017: Advances in Immunology
https://www.readbyqxmd.com/read/28411882/in-vitro-generation-of-interleukin-10-secreting-b-regulatory-cells-from-donor-adipose-tissue-derived-mesenchymal-stem-cells-and-recipient-peripheral-blood-mononuclear-cells-for-potential-cell-therapy
#15
Kunal S Gupte, Aruna V Vanikar, Hargovind L Trivedi, Chetan N Patel, Jignesh V Patel
BACKGROUND: Interleukin-10 secreting B-cells are a major subset of B-regulatory cells (B-regs), commonly recognized as CD19(+)/38(hi)/24(hi)/IL10(+). They carry out immunomodulation by release of specific cytokines and/or cell-to-cell contact. We have generated B-regs in-vitro from donor adipose tissue derived mesenchymal stem cells (AD-MSC) and renal allograft recipient (RAR) peripheral blood mononuclear cells (PBMC) for potential cell therapy. MATERIAL AND METHODS: Mononuclear cells separated by density gradient centrifugation from 50 ml anti-coagulated blood of 15-RAR and respective donors were analysed for baseline B-regs using appropriate antibodies...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28411872/induction-therapy-with-the-selective-interleukin-23-inhibitor-risankizumab-in-patients-with-moderate-to-severe-crohn-s-disease-a-randomised-double-blind-placebo-controlled-phase-2-study
#16
Brian G Feagan, William J Sandborn, Geert D'Haens, Julián Panés, Arthur Kaser, Marc Ferrante, Edouard Louis, Denis Franchimont, Olivier Dewit, Ursula Seidler, Kyung-Jo Kim, Markus F Neurath, Stefan Schreiber, Paul Scholl, Chandrasena Pamulapati, Bojan Lalovic, Sudha Visvanathan, Steven J Padula, Ivona Herichova, Adina Soaita, David B Hall, Wulf O Böcher
BACKGROUND: The interleukin-23 pathway is implicated genetically and biologically in the pathogenesis of Crohn's disease. We aimed to assess the efficacy and safety of risankizumab (BI 655066, Boehringer Ingelheim, Ingelheim, Germany), a humanised monoclonal antibody targeting the p19 subunit of interleukin-23, in patients with moderately-to-severely active Crohn's disease. METHODS: In this randomised, double-blind, placebo-controlled phase 2 study, we enrolled patients at 36 referral sites in North America, Europe, and southeast Asia...
April 12, 2017: Lancet
https://www.readbyqxmd.com/read/28408199/interleukin-15-and-cisplatin-co-encapsulated-thermosensitive-polypeptide-hydrogels-for-combined-immuno-chemotherapy
#17
Xilong Wu, Yundi Wu, Hongbo Ye, Shuangjiang Yu, Chaoliang He, Xuesi Chen
In situ-forming thermosensitive hydrogels based on poly(ethylene glycol)-poly(γ-ethyl-l-glutamate) diblock copolymers (mPEG-b-PELG) were prepared for the co-delivery of interleukin-15 (IL-15) and cisplatin (CDDP). The polypeptide-based hydrogels as local drug delivery carriers could reduce the systemic toxicity, degrade thoroughly within 3weeks after subcutaneous injection into rats and display an acceptable biocompatibility. When incubated with mouse melanoma B16 cells, only the CDDP-treated groups had significant effects on the S phase cell-cycle arrest in melanoma cells...
April 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28403941/obesity-is-positively-associated-with-arachidonic-acid-derived-5-and-11-hydroxyeicosatetraenoic-acid-hete
#18
Charles Austin Pickens, Lorraine M Sordillo, Chen Zhang, Jenifer I Fenton
BACKGROUND: Oxylipids are oxygenated polyunsaturated fatty acid (PUFA) metabolites that are responsible for the onset and resolution of the inflammatory response. Enzymatic oxygenation through the lipoxygenase (LOX) or cytochrome P450 (CYP) pathways can form oxylipids that have either proinflammatory or proresolving functions depending on the type of PUFA substrate and degree of metabolism. The objective of this study was to determine how PUFA substrates and their corresponding oxylipids are associated with obesity...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28400869/serum-cytokine-profile-in-asian-indian-patients-with-takayasu-arteritis-and-its-association-with-disease-activity
#19
Ruchika Goel, Jayakanthan Kabeerdoss, Babu Ram, John Antony Jude Prakash, Sudhir Babji, Aswin Nair, Lakshmanan Jeyaseelan, Visalakshi Jeyaseelan, John Mathew, Veeraraghavan Balaji, George Joseph, Debashish Danda
BACKGROUND: Arterial inflammation Takayasu arteritis (TA) is an outcome of balance between pro- and anti-inflammatory cytokines. Comprehensive assessment of these cytokines is important for understanding pathogenesis and assessing disease activity. OBJECTIVE: To study pro- and anti-inflammatory cytokines representing different T-helper cell pathway in serum samples of Asian Indian patients with TA and to assess their association with disease activity. METHODS: Consecutive Indian patients with TA were assayed for serum interferon-γ, interleukin-6, interleukin-23, interleukin-17, interleukin-10 and transforming growth factor- β levels at baseline and follow up visit...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28397727/neutralization-of-interleukin-9-decreasing-mast-cells-infiltration-in-experimental-autoimmune-encephalomyelitis
#20
Jun-Jie Yin, Xue-Qiang Hu, Zhi-Feng Mao, Jian Bao, Wei Qiu, Zheng-Qi Lu, Hao-Tian Wu, Xiao-Nan Zhong
BACKGROUND: Th9 cells are a newly discovered CD4+ T helper cell subtype, characterized by high interleukin (IL)-9 secretion. Growing evidences suggest that Th9 cells are involved in the pathogenic mechanism of multiple sclerosis (MS). Mast cells are multifunctional innate immune cells, which are perhaps best known for their role as dominant effector cells in allergies and asthma. Several lines of evidence point to an important role for mast cells in MS and its animal models. Simultaneously, there is dynamic "cross-talk" between Th9 and mast cells...
April 20, 2017: Chinese Medical Journal
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