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https://www.readbyqxmd.com/read/29332324/effects-of-macrolide-and-corticosteroid-in-neutrophilic-asthma-mouse-model
#1
Tai Joon An, Chin Kook Rhee, Ji Hye Kim, Young Rong Lee, Jin Young Chon, Chan Kwon Park, Hyoung Kyu Yoon
BACKGROUND: Asthma is a disease of chronic airway inflammation with heterogeneous features. Neutrophilic asthma is corticosteroid-insensitive asthma related to absence or suppression of TH2 process and increased TH1 and/or TH17 process. Macrolides are immunomodulatory drug that reduce airway inflammation, but their role in asthma is not fully known. The purpose of this study was to evaluate the role of macrolides in neutrophilic asthma and compare their effects with those of corticosteroids...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29332095/both-serum-brain-derived-neurotrophic-factor-and-interleukin-6-levels-are-not-associated-with-therapeutic-response-to-lamotrigine-augmentation-therapy-in-treatment-resistant-depressive-disorder
#2
Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. METHODS: The subjects were 46 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
January 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29332092/early-life-stress-activates-glial-cells-in-the-hippocampus-but-attenuates-cytokine-secretion-in-response-to-an-immune-challenge-in-rat-pups
#3
Luis Miguel Saavedra, Bertha Fenton Navarro, Luz Torner
OBJECTIVE: Early life stress (ELS) increases the vulnerability to developing psychopathological disorders in adulthood that are accompanied by brain inflammatory processes. However, it is not known how a combined double hit (stress and immune) at an early age affects the response of the neuroimmune system. Here we investigated the effect of periodic maternal separation (MS) followed by administration of lipopolysaccharide (LPS) on glial cells in the CA3 region and hilus of the hippocampus and on cytokine release on postnatal day (PN) 15...
January 13, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29329608/polyphenols-isolated-from-acacia-mearnsii-bark-with-anti-inflammatory-and-carbolytic-enzyme-inhibitory-activities
#4
Jia Xiong, Mary H Grace, Debora Esposito, Slavko Komarnytsky, Fei Wang, Mary Ann Lila
The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract (B) and fractions (B1-B7) obtained by high-speed counter-current chromatography (HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7 (total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g-1, respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g-1, respectively) showed significant activities against reactive oxygen species (ROS), nitric oxide (NO) production, and expression of pro-inflammatory genes interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) in a lipopolysaccharide (LPS)-stimulated mouse macrophage cell line RAW 264...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29325459/is-cord-blood-hepcidin-influenced-by-the-low-grade-acute-phase-response-occurring-during-delivery-%C3%A2-a-small-scale-longitudinal-study
#5
Michael Hoppe, Lena Hulthén, Gösta Samuelson
AIM: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6 and biomarkers of fetal iron status. MATERIALS AND METHODS: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth. RESULTS: In T3, S-ferritin (median 14 µg/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29325294/-effects-of-lactobacillus-paracasei-n1115-combined-with-fructooligosaccharides-on-non-alcoholic-fatty-liver-disease-induced-by-high-fat-diet-in-mice
#6
F F Yao, P Y Zheng, H Huang, L M Bai, Y R Ding, L Mei, S M Liu
Objective: To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. Methods: A total of 50 male C57 mice were randomly and equally divided into five experimental groups. Group 1 received a normal diet (ND). Other four groups received a high-fat diet (HFD) to establish NAFLD models. In addition to HFD, group 3 received Lactobacillus paracasei N1115 (2.2×10(9) CFU/mL), group 4 received FOS (4 g/kg per day), and group 5 received Lactobacillus paracasei N1115 (2...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29325291/-hepatitis-b-core-antigen-promotes-invasion-of-hepatocellular-carcinoma-cell-line-hepg2-2-15-via-toll-like-receptor-4
#7
H R Hou, Y Kang, Y K Li, Y L Zeng, J F Wei, G G Ding, Z Peng, J Shang
Objective: To investigate the effect of hepatitis B core antigen (HBcAg) in promoting the invasion of hepatitis B virus (HBV)-related hepatocellular carcinoma cell line HepG2.2.15 and the role of Toll-like receptor 4 (TLR4) in the mechanism. Methods: TLR4 mRNA and protein expression in HepG2 cells and HepG2.2.15 cells was measured by reverse transcription real-time PCR and Western blot analysis, respectively. HepG2.2.15 cells were transfected with TLR4 specific small interfering RNA (siRNA) to silence TLR4 expression, and stimulated by recombinant HBcAg in culture...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29324380/estimated-individual-inhaled-dose-of-fine-particles-and-indicators-of-lung-function-a-pilot-study-among-chinese-young-adults
#8
Tian Xu, Jian Hou, Juan Cheng, Runbo Zhang, Wenjun Yin, Cheng Huang, Xiaochuan Zhu, Weihong Chen, Jing Yuan
Fine particle (PM2.5)-related lung damage has been reported in most studies regarding environmental or personal PM2.5 concentrations. To assess effects of personal PM2.5 exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM2.5 based on their microenvironmetal PM2.5 concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day...
January 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29320547/dyslipidemia-chronic-inflammation-and-subclinical-atherosclerosis-in-children-and-adolescents-infected-with-hiv-the-posithive-health-study
#9
Luiz Rodrigo Augustemak de Lima, Edio Luiz Petroski, Yara Maria Franco Moreno, Diego Augusto Santos Silva, Erasmo Benício de Moraes Santos Trindade, Aroldo Prohmann de Carvalho, Isabela de Carlos Back
HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc...
2018: PloS One
https://www.readbyqxmd.com/read/29319332/nebivolol-attenuates-oxidative-stress-and-inflammation-in-a-guinea-pig-model-of-ovalbumin-induced-asthma-a-possible-mechanism-for-its-favorable-respiratory-effects
#10
Sally A Abuelezz
An experimental model of ovalbumin (OVA) induced asthma was used to assess the effects of nebivolol, the third-generation selective β1-adrenergic receptor blocker, on airway reactivity, lung inflammation, and oxidative stress markers. The asthma induction protocol was done by OVA sensitization and challenge. Guinea pigs were classified into control, asthmatic, or asthmatic receiving nebivolol either 7.5 or 15 mg·kg-1·day-1 orally. At the end of the study respiratory, the anti-inflammatory and antioxidative effects of nebivolol were assessed...
January 10, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29316218/local-administration-of-nuclear-factor-of-activated-t-cells-nfat-c1-inhibitor-to-suppress-early-resorption-and-inflammation-induced-by-bone-morphogenetic-protein-2
#11
Ri Youn Kim, Yeju Seong, Tae Hyung Cho, Beomseok Lee, In Sook Kim, Soon Jung Hwang
Nuclear factor of activated T cells (NFAT)-c1 is known as a key regulator in osteoclast differentiation and immune response. This study is a follow-up to our previous study showing the anti-resorptive activity of VIVIT, a peptide type NFATc1 inhibitor, using absorbable collagen sponge (ACS). This study aimed to investigate the effective concentration range of local VIVIT that suppresses early excessive osteoclast activation and inflammation induced by high-dose recombinant human bone morphogenetic protein (rhBMP)-2 and concomitantly enhances bone healing in a rat critical-sized calvaria defect model...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29306151/enhancement-of-immune-response-of-piglets-to-pcv-2-vaccine-by-porcine-il-2-and-fusion-il-4-6-gene-entrapped-in-chitosan-nanoparticles
#12
Yi Chen, Tingyu Song, Yong-Le Xiao, Xiaoping Wan, Luyi Yang, Jinghai Li, Guangzhi Zeng, Pengfei Fang, Ze-Zhou Wang, Rong Gao
In order to develop a novel effective immunomodulator to enhance pig resistance against post-weaning multi systemic wasting syndrome (PMWS), a recombinant plasmid co-expressing pig interleukin-2 (IL-2) and fusion interleukin-4/6 (IL-4/6) genes, designated VRIL4/6-2, was constructed and encapsulated in chitosan (CS) nanoparticles prepared by the ionotropic gelation method. Then 21-day old piglets were divided into two groups and intramuscularly injected respectively with VPIL4/6-2-CS and saline along with the porcine circovirus-2 (PCV-2) vaccine...
December 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29305826/hepcidin-soluble-transferrin-receptor-and-il-6-levels-in-obese-children-and-adolescents-with-and-without-type-2-diabetes-mellitus-impaired-glucose-tolerance-and-their-association-with-obstructive-sleep-apnea
#13
S Shalitin, V Deutsch, R Tauman
PURPOSE: Obesity, type 2 diabetes mellitus (T2DM), and obstructive sleep apnea (OSA) are associated with chronic low-grade inflammation. Iron metabolism is linked with insulin-resistant states and with OSA in adults. The association of body iron status with T2DM in children remains undefined. We aimed to evaluate plasma interleukin-6 (IL-6), hepcidin, and soluble transferrin receptor (sTfR) levels in obese patients with T2DM or impaired glucose tolerance (IGT) and in those without, and the contribution of OSA to their levels...
January 5, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29304171/mcp-1-kc-like-and-il-8-as-critical-mediators-of-pathogenesis-caused-by-babesia-canis
#14
Asier Galán, Iva Mayer, Renata Barić Rafaj, Krešo Bendelja, Velimir Sušić, José Joaquín Cerón, Vladimir Mrljak
Canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by Babesia canis upon treatment with Imizol®. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease...
2018: PloS One
https://www.readbyqxmd.com/read/29301686/is-there-an-effect-of-environmental-temperature-on-the-response-to-an-antigen-and-the-metabolic-rate-in-pups-of-the-rodent-octodon-degus
#15
Natalia Ramirez-Otarola, Janyra Espinoza, Alexis M Kalergis, Pablo Sabat
Environmental temperature is a variable that influences all aspects of organisms, from physiological, e.g. immune function, and morphological traits to behavior. Recent studies have reported that environmental temperature modulates organisms' thermoregulatory capacity and immune response, suggesting that trade-offs must be made between thermoregulation and immune function. Despite this, studies that evaluate this trade-off in developing endotherms are scarce. The aim of this study was to evaluate the effects of environmental temperature experienced during development on the response to an antigen and its energetic costs in the precocial rodent Octodon degus...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29299904/clinical-significance-of-serum-adipokines-according-to-body-mass-index-in-patients-with-clinically-localized-prostate-cancer-undergoing-radical-prostatectomy
#16
Minyong Kang, Seok Soo Byun, Sang Eun Lee, Sung Kyu Hong
PURPOSE: The aim of this study was to investigate the clinical significance of 7 circulating adipokines according to body mass index (BMI) in Korean men with localized prostate cancer (PCa) undergoing radical prostatectomy (RP). MATERIALS AND METHODS: Sixty-two of 65 prospectively enrolled patients with clinically localized PCa who underwent RP between 2015 and 2016 were evaluated. Patients were classified into 2 groups according to their BMI: non-obese (<25 kg/m²) and obese (≥25 kg/m²)...
January 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29298649/an-inflammation-related-nutrient-pattern-is-associated-with-both-brain-and-cognitive-measures-in-a-multiethnic-elderly-population
#17
Yian Gu, Jennifer J Manly, Richard P Mayeux, Adam M Brickman
BACKGROUND: Accumulating evidence suggest that dietary factors are associated with Alzheimer's disease, and brain and cognitive health. It is unclear whether inflammation explains this association. OBJECTIVE: To examine whether an inflammation-related nutrient pattern (INP) was associated with neuroimaging and cognitive measures of brain health. METHOD: The current cross-sectional study included 330 non-demented elderly (mean age 79 years at MRI scan) participants in a multi-ethnic, community-based cohort study who had information on nutritional intakes (estimated from food frequency questionnaire), circulating C-reactive protein and interleukin-6 (measured by ELISA), MRI scans, and cognition...
January 1, 2018: Current Alzheimer Research
https://www.readbyqxmd.com/read/29297432/vitamin-d-deficiency-in-patients-with-tuberculous-meningitis-and-its-relationship-with-treatment-outcome
#18
G V Dangeti, S Mailankody, C Neeradi, J Mandal, R Soundravally, N M Joseph, S Kamalanathan, R P Swaminathan, T Kadhiravan
SETTING: Data on vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of vitamin D might be mediated through interleukin-1β (IL-1β). OBJECTIVE: To assess the frequency of vitamin D deficiency among TBM patients, its association with treatment outcomes and correlation between vitamin D and IL-1β levels in cerebrospinal fluid (CSF). DESIGN: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital in southern India...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29296921/interleukins-12-and-15-induce-cytotoxicity-and-early-nk-cell-differentiation-in-type-3-innate-lymphoid-cells
#19
Ana Raykova, Paolo Carrega, Frank M Lehmann, Robert Ivanek, Vanessa Landtwing, Isaak Quast, Jan D Lünemann, Daniela Finke, Guido Ferlazzo, Obinna Chijioke, Christian Münz
Type 3 innate lymphoid cells (ILC3s) fulfill protective functions at mucosal surfaces via cytokine production. Although their plasticity to become ILC1s, the innate counterparts of type 1 helper T cells, has been described previously, we report that they can differentiate into cytotoxic lymphocytes with many characteristics of early differentiated natural killer (NK) cells. This transition is promoted by the proinflammatory cytokines interleukin 12 (IL-12) and IL-15, and correlates with expression of the master transcription factor of cytotoxicity, eomesodermin (Eomes)...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29296276/preparation-of-transgenic-iranian-lizard-leishmania-coding-hil-12
#20
Tahereh Donyavi, Mojgan Bandehpour, Bahram Kazemi
Background and Objectives: Leishmania are intracellular flagellate protozoan parasites cause a wide spectrum of clinical manifestations in human. The immunological basis for resistance against leishmaniasis depends on Thl responses in the course of performance of cytokines like IL-12. In this study, a transgenic Leishmania coding human IL-12 was produced that can be used in Leishmanization. Materials and Methods: A fragment of Iranian lizard Leishmania (I.L.L) gene, named Cysteine Peptidase C (CPC), was amplified separately as two parts with PCR reaction...
October 2017: Iranian Journal of Microbiology
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