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https://www.readbyqxmd.com/read/29138391/maternal-impulse-control-disability-and-developmental-disorder-traits-are-risk-factors-for-child-maltreatment
#1
Yoshiyuki Tachibana, Kenji Takehara, Naoko Kakee, Masashi Mikami, Eisuke Inoue, Rintaro Mori, Erika Ota, Tomoe Koizumi, Makiko Okuyama, Takahiko Kubo
Previous work has suggested that maternal developmental disorder traits related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are significantly associated with child maltreatment. However, there may be other important maternal characteristics that contribute to child maltreatment. We hypothesized that maternal impulse control disability may also affect child maltreatment in addition to maternal developmental disorder traits. We aimed to test this hypothesis via a cohort study performed in Tokyo (n = 1,260)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112530/the-prevalence-of-psychiatric-disorders-and-mental-health-services-utilization-by-parents-and-relatives-living-with-individuals-with-autism-spectrum-disorders-in-puerto-rico
#2
Ernesto Magallón-Neri, Dorilyz Vila, Katyana Santiago, Pedro García, Glorisa Canino
Knowledge about prevalence rates of psychiatric disorders and mental health services use among parents and relatives of persons with autism spectrum disorder (ASD) is limited, particularly when referring to epidemiologic samples. The current study is based on an island-wide probabilistic multistage cluster sample of adult individuals (N = 3062) living in Puerto Rico. Results showed a significantly higher rate of attention deficit hyperactivity disorder and serious mental illness in parents (n = 34) or relatives (n = 34) of ASD individuals, as compared with the Puerto Rico adult population as a whole...
November 4, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29112459/atomoxetine-parent-training-and-their-effects-on-sleep-in-youth-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#3
Jill A Hollway, Marrisa Mendoza-Burcham, Rebecca Andridge, Michael G Aman, Benjamin Handen, L Eugene Arnold, Luc Lecavalier, Craig Williams, Laura Silverman, Tristram Smith
OBJECTIVE: Sleep disturbance is often a problem for children with either autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Psychostimulant medications used to treat ADHD symptoms can exacerbate this problem. For children with ASD and ADHD, atomoxetine (ATX) is a viable alternative to psychostimulants. We investigated the effects of ATX and a manualized parent training (PT) program targeting noncompliance, on the sleep quality of children with ASD and ADHD...
November 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29112198/co-aggregation-of-major-psychiatric-disorders-in-individuals-with-first-degree-relatives-with-schizophrenia-a-nationwide-population-based-study
#4
C-M Cheng, W-H Chang, M-H Chen, C-F Tsai, T-P Su, C-T Li, S-J Tsai, J-W Hsu, K-L Huang, W-C Lin, T-J Chen, Y-M Bai
A previous genetic study has suggested that schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) share common disease-associated genes. However, whether individuals with first-degree relatives (FDRs) with schizophrenia have a higher risk of these major psychiatric disorders requires further investigation. This study used Taiwan's National Health Insurance Research Database and identified 151 650 patients with schizophrenia and 227 967 individuals with FDRs with schizophrenia...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29107450/epilepsy-as-a-network-disorder-1-what-can-we-learn-from-other-network-disorders-such-as-autistic-spectrum-disorder-and-mood-disorders
#5
REVIEW
Andres M Kanner, Helen Scharfman, Nathalie Jette, Evdokia Anagnostou, Christophe Bernard, Carol Camfield, Peter Camfield, Karen Legg, Ilan Dinstein, Peter Giacobe, Alon Friedman, Bernd Pohlmann-Eden
Epilepsy is a neurologic condition which often occurs with other neurologic and psychiatric disorders. The relation between epilepsy and these conditions is complex. Some population-based studies have identified a bidirectional relation, whereby not only patients with epilepsy are at increased risk of suffering from some of these neurologic and psychiatric disorders (migraine, stroke, dementia, autism, depression, anxiety disorders, Attention deficit hyperactivity disorder (ADHD), and psychosis), but also patients with these conditions are at increased risk of suffering from epilepsy...
October 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29104944/psychotropic-medication-use-in-autism-spectrum-disorders-may-affect-functional-brain-connectivity
#6
Annika C Linke, Lindsay Olson, Yangfeifei Gao, Inna Fishman, Ralph-Axel Müller
Background: Prescription of psychotropic medications is common in autism spectrum disorders (ASDs), either off-label or to treat comorbid conditions such as ADHD or depression. Psychotropic medications are intended to alter brain function. Yet, studies investigating the functional brain organization in ASDs rarely take medication usage into account. This could explain some of the inconsistent findings of atypical brain network connectivity reported in the autism literature. Methods: The current study tested whether functional connectivity patterns, as assessed with functional magnetic resonance imaging (fMRI), differed in a cohort of 49 children and adolescents with ASDs based on psychotropic medication status, and in comparison with 50 matched typically developing (TD) participants...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29102665/perinatal-exposure-to-low-dose-imidacloprid-causes-adhd-like-symptoms-evidences-from-an-invertebrate-model-study
#7
Seoyoung Kim, Hee-Seok Lee, Yooheon Park
The fundamental diagnoses of attention deficit hyperactivity disorder (ADHD) and autism consists of inattention, hyperactivity, and impulsivity, which lead to abnormal social interactions and repetitive and restricted behavior. Several food contaminants are suspected of being a possible contributing factor to the present-day increase in diseases, such as obesity and ADHD, and pesticides are also considered as a contributor to the increased prevalence of ADHD. Imidacloprid is a neonicotinoid insecticide with lower toxicity to mammals...
November 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29096777/efficacy-and-safety-of-pediatric-prolonged-release-melatonin-for-insomnia-in-children-with-autism-spectrum-disorder
#8
Paul Gringras, Tali Nir, John Breddy, Anat Frydman-Marom, Robert L Findling
OBJECTIVE: To assess the efficacy and safety of novel pediatric-appropriate, prolonged-release melatonin minitablets (PedPRM) versus placebo for insomnia in children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD). METHOD: A total of 125 children and adolescents (2-17.5 years of age; 96.8% ASD, 3.2% Smith-Magenis syndrome [SMS]) whose sleep failed to improve on behavioral intervention alone were randomized (1:1 ratio), double-blind, to receive PedPRM (2 mg escalated to 5 mg) or placebo for 13 weeks...
November 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29083944/the-relation-between-emotional-intelligence-and-resilience-in-at-risk-populations
#9
Adam W McCrimmon, Emma A Climie, Stephany Huynh
PURPOSE: Resilience factors and their relation to emotional intelligence (EI) as a potential strength for children with attention-deficit/hyperactivity disorder (ADHD) or high-functioning autism spectrum disorder (HFASD) were investigated. Children with either ADHD or HFASD were hypothesized to demonstrate reduced EI and differential relations between EI and resilience as compared to typically developing (TD) children. METHODS: Fifty-four children aged 8-12 years (18 with ADHD, 18 with HFASD, and 18 TD controls) completed the Resilience Scales for Children and Adolescents and BarOn Emotional Quotient Inventory...
October 30, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29081833/parent-reported-problematic-sleep-behaviors-in-children-with-comorbid-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#10
Katharine C Reynolds, Michelle Patriquin, Candice A Alfano, Katherine A Loveland, Deborah A Pearson
BACKGROUND: Sleep problems are frequent and well documented in children with Autism Spectrum Disorders (ASD), children with Attention Deficit/Hyperactivity Disorder (ADHD) and children with internalizing problems, however limited work has examined sleep problems in children presenting with comorbid ASD/ADHD. In healthy children, sleep problems negatively impact social, emotional, and academic functioning. The current study sought to examine diagnostic severity as predictors of sleep problems in children with comorbid ASD/ADHD...
July 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/29077142/-non-invasive-neurostimulation-in-the-treatment-of-child-and-adolescent-psychiatry
#11
S van der Meersche, G Lemmens, C Matton, C Baeken
Neurostimulation is a potentially interesting treatment option for children and adolescents with psychiatric disorders.<br/> AIM: To review the efficacy of two non-invasive neurostimulation techniques, namely repetitive transcranial magnetic stimulation (rtms) and transcranial direct current stimulation (tdcs), in the treatment of child and adolescent psychiatric disorders.<br/> METHOD: We searched the literature research using PubMed.<br/> RESULTS: There is some evidence that rtms is being used to treat unipolar depression, psychosis, autism spectrum disorder, attention deficit hyperactivity disorder and tic disorder...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29075217/sensory-processing-in-children-with-autism-spectrum-disorder-and-or-attention-deficit-hyperactivity-disorder-in-the-home-and-classroom-contexts
#12
Pilar Sanz-Cervera, Gemma Pastor-Cerezuela, Francisco González-Sala, Raúl Tárraga-Mínguez, Maria-Inmaculada Fernández-Andrés
Children with neurodevelopmental disorders often show impairments in sensory processing (SP) and higher functions. The main objective of this study was to compare SP, praxis and social participation (SOC) in four groups of children: ASD Group (n = 21), ADHD Group (n = 21), ASD+ADHD Group (n = 21), and Comparison Group (n = 27). Participants were the parents and teachers of these children who were 5-8 years old (M = 6.32). They completed the Sensory Processing Measure (SPM) to evaluate the sensory profile, praxis and SOC of the children in both the home and classroom contexts...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29070492/vitamin-d-deficiency-infertility-and-neurodevelopmental-diseases-attention-deficit-hyperactivity-disorder-autism-and-schizophrenia
#13
Michael J Berridge
The process of development depends on a progressive sequence of events that are carefully orchestrated by a number of signalling systems. Alteration in these signalling events results in infertility and neurodevelopmental diseases such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and schizophrenia. A prominent role throughout development beginning at fertilization and continuing through early development, implantation and organ differentiation such as heart and brain development is regulated by Ca(2+) signalling...
October 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29065375/cryptorchidism-and-increased-risk-of-neurodevelopmental-disorders
#14
Jianping Chen, Henrik Toft Sørensen, Maohua Miao, Hong Liang, Vera Ehrenstein, Ziliang Wang, Wei Yuan, Jiong Li
Male congenital malformations as cryptorchidism may contribute to the development of neurodevelopmental disorders directly or via shared familial genetic and/or environmental factors, but the evidence is sparse. Using population-based health registries, we conducted a cohort study of all liveborn singleton boys in Denmark during 1979-2008. Boys with a diagnosis of cryptorchidism were categorized into the exposed cohort and the other boys into the unexposed comparison cohort. The outcomes were diagnoses of any neurodevelopmental disorders and their subtypes...
October 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29058593/brain-donation-in-psychiatry-results-of-a-dutch-prospective-donor-program-among-psychiatric-cohort-participants
#15
Geertje M de Lange, Marleen Rademaker, Marco P Boks, Saskia J M C Palmen
BACKGROUND: Human brain tissue is crucial to study the molecular and cellular basis of psychiatric disorders. However, the current availability of human brain tissue is inadequate. Therefore, the Netherlands Brain Bank initiated a program in which almost 4.000 participants of 15 large Dutch psychiatric research cohorts were asked to register as prospective brain donors. METHODS: We approached patients with schizophrenia, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, families with a child with autism or Attention Deficit Hyperactivity Disorder, healthy relatives and healthy unrelated controls, either face-to-face or by post...
October 20, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29056086/prevalence-and-correlates-of-autism-spectrum-disorders-in-quebec
#16
Fatoumata Binta Diallo, Éric Fombonne, Steve Kisely, Louis Rochette, Helen-Maria Vasiliadis, Alain Vanasse, Manon Noiseux, Éric Pelletier, Johanne Renaud, Danielle St-Laurent, Alain Lesage
OBJECTIVE: To estimate the prevalence, comorbidities, and service use of people with autism spectrum disorders (ASDs) based on data from Quebec Integrated Chronic Diseases Surveillance System (QICDSS). METHODS: We included all residents up to age 24 eligible for health plan coverage who were in Quebec for at least 1 day from January 1, 1996, to March 31, 2015. To be considered as having an ASD, an individual had to have had at least 1 physician claim or hospital discharge abstract from 2000 to 2015 indicating one of the following ASD diagnosis codes: ICD-9 codes 299...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29043919/beyond-survival-5-year-neurodevelopmental-follow-up-of-a-cohort-of-preterm-infants-in-colombo-sri-lanka
#17
S P Sumanasena, D V Vipulaguna, M M Mendis, N S Gunawardena
BACKGROUND: There is a lack of information on long-term neurodevelopmental outcome in preterm neonates in low- and middle-income countries. OBJECTIVES: To describe the developmental attainments of preterm neonates followed up for 5 years and to identify the risk factors for impairment. METHOD: A prospective descriptive cohort study was undertaken in neonates of 34 weeks gestation born within a period of 12 months at a single tertiary maternity and neonatal unit in Colombo, Sri Lanka...
October 18, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29042781/children-with-borderline-intellectual-functioning-and-autism-spectrum-disorder-developmental-trajectories-from-4-to-11-years-of-age
#18
Martina Barnevik Olsson, Anette Holm, Joakim Westerlund, Åsa Lundholm Hedvall, Christopher Gillberg, Elisabeth Fernell
BACKGROUND: Studies on autism have tended to focus either on those with intellectual disability (ie, those with intellectual quotient [IQ] under 70) or on the group that is referred to as "high-functioning", that is, those with borderline, average or above average IQ. The literature on cognition and daily functioning in autism spectrum disorder combined specifically with borderline intellectual functioning (IQ 70-84) is limited. METHODS: From a representative group of 208 preschool children diagnosed with autism spectrum disorder, those 50 children in the group with borderline intellectual functioning at ages 4...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29038598/male-specific-deficits-in-natural-reward-learning-in-a-mouse-model-of-neurodevelopmental-disorders
#19
N M Grissom, S E McKee, H Schoch, N Bowman, R Havekes, W T O'Brien, E Mahrt, S Siegel, K Commons, C Portfors, T Nickl-Jockschat, T M Reyes, T Abel
Neurodevelopmental disorders, including autism spectrum disorders, are highly male biased, but the underpinnings of this are unknown. Striatal dysfunction has been strongly implicated in the pathophysiology of neurodevelopmental disorders, raising the question of whether there are sex differences in how the striatum is impacted by genetic risk factors linked to neurodevelopmental disorders. Here we report male-specific deficits in striatal function important to reward learning in a mouse model of 16p11.2 hemideletion, a genetic mutation that is strongly associated with the risk of neurodevelopmental disorders, particularly autism and attention-deficit hyperactivity disorder...
October 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29038237/the-gain-of-function-integrin-%C3%AE-3-pro33-variant-alters-the-serotonin-system-in-the-mouse-brain
#20
Michael R Dohn, Christopher G Kooker, Lisa Bastarache, Tammy Jessen, Capria Rinaldi, Seth Varney, Matthew D Mazalouskas, Hope Pan, Kendra H Oliver, Digna R Velez Edwards, James S Sutcliffe, Joshua C Denny, Ana M D Carneiro
Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link the ITGB3 gene encoding the integrin β3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). The ITGB3 coding polymorphism Leu33Pro (rs5918, Pl(A2)) produces hyperactive αvβ3 receptors that influence whole blood 5-HT levels and may influence risk for autism spectrum disorder (ASD)...
October 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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