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Matthew Santore

Bennett W Calder, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Jessica A Zagory, Christian J Streck
INTRODUCTION: The utility of FAST in children is poorly defined with considerable practice variation. Our purpose was to investigate the role of FAST for intraabdominal injury (IAI) and IAI requiring acute intervention (IAI-I) in children following blunt abdominal trauma (BAT). METHODS: We prospectively enrolled children <16 years following BAT at 14 Level-One Pediatric Trauma Centers over a 1-year period. Patients who underwent FAST were compared to those that did not using descriptive statistics and univariate analysis; p<0...
June 6, 2017: Journal of Trauma and Acute Care Surgery
Chase A Arbra, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Christian J Streck
BACKGROUND: Pediatric intraabdominal injuries (IAI) from blunt abdominal trauma (BAT) rarely require emergent intervention. For those children undergoing procedural intervention, our aim was to understand the timing and indications for operation and angiographic embolization. METHODS: We prospectively enrolled children <16 years following BAT at 14 Level-One Pediatric Trauma Centers over a 1-year period. Patients with IAI who received an intervention (IAI-I) were compared to those who did not receive an intervention using descriptive statistics and univariate analysis; p < 0...
April 27, 2017: Journal of Trauma and Acute Care Surgery
Heather L Short, Helene B Fevrier, Jonathan A Meisel, Matthew T Santore, Kurt F Heiss, Mark L Wulkan, Mehul V Raval
INTRODUCTION: Prolonged operative time (OT) is considered a reflection of procedural complexity and may be associated with poor outcomes. Our purpose was to explore the association between prolonged OT and complications in children's surgery. METHODS: 182,857 cases from the 2012-2014 NSQIP-Pediatric were organized into 33 groups. OT for each group was analyzed by quartile, and regression models were used to determine the relationship between prolonged OT and complications...
March 20, 2017: Journal of Pediatric Surgery
Erik G Pearson, Caitlin A Fitzgerald, Matthew T Santore
Pediatric thoracic trauma is relatively uncommon but results in disproportionately high levels of morbidity and mortality when compared with other traumatic injuries. These injuries are often more devastating due to differences in children׳s anatomy and physiology relative to adult patients. A high index of suspicion is of utmost importance at the time of presentation because many significant thoracic injuries will have no external signs of injury. With proper recognition and management of these injuries, there is an associated improved long-term outcome...
February 2017: Seminars in Pediatric Surgery
Christian J Streck, Adam M Vogel, Jingwen Zhang, Eunice Y Huang, Matthew T Santore, Kuojen Tsao, Richard A Falcone, Melvin S Dassinger, Robert T Russell, Martin L Blakely
BACKGROUND: Computed tomography is commonly used to rule out intra-abdominal injury (IAI) in children, despite associated cost and radiation exposure. Our purpose was to derive a prediction rule to identify children at very low risk for IAI after blunt abdominal trauma (BAT) for whom a CT scan of the abdomen would be unnecessary. STUDY DESIGN: We prospectively enrolled children younger than 16 years of age who presented after BAT at 14 Level I pediatric trauma centers during 1 year...
April 2017: Journal of the American College of Surgeons
Adam Vogel, Robert Russell, Melvin Dassinger, Martin Blakely, Matthew Santore, Kuojen Tsao, Eunice Huang, Christian Streck
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Julia K Shinnick, Nasim Khoshnam, Sydney R Archer, Philip C Quigley, Mark Robinson, Sarah Keene, Matthew T Santore, Sarah J Hill, Binita Patel, Bahig Shehata
Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35 year-old G1P0 woman and 36 year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. On histopathologic examination, the placentas demonstrated vascular anastomoses between the surviving co-twin and the "vanished" fetal sac...
June 6, 2016: Pediatric and Developmental Pathology
Martha-Conley E Ingram, Ragavan V Siddharthan, Andrew D Morris, Sarah J Hill, Curtis D Travers, Courtney E McKracken, Kurt F Heiss, Mehul V Raval, Matthew T Santore
BACKGROUND: There are no widely accepted guidelines for management of pediatric patients who have evidence of solid organ contrast extravasation ("blush") on computed tomography (CT) scans following blunt abdominal trauma. We report our experience as a Level 1 pediatric trauma center in managing cases with hepatic and splenic blush. METHODS: All pediatric blunt abdominal trauma cases resulting in liver or splenic injury were queried from 2008 to 2014. Patients were excluded if a CT was unavailable in the medical record...
August 2016: Journal of Trauma and Acute Care Surgery
William T Warnock, Nasim Khoshnam, Kristin M Bird, Lauren R Schaffer, L H Lou, C Matthew Hawkins, Matthew T Santore, Sarah Hill, Anne E Gill, Pooya Hoseinzadeh, Bahig M Shehata
This is a case of a newborn female with congenital pancreatic cysts discovered incidentally. The 5-week-old infant had multiple abdominal cysts originating from the pancreas. When the radiologist catheter placement failed to alleviate the symptoms, the infant underwent laparoscopic excision. The lesion, however, recurred 11 months after the first excision, leading to a second surgical procedure including excision and marsupialization. A review of the literature revealed that this is a rare condition. Herein, we discuss the characteristics of the case, including medical imaging, drainage catheter placement, surgical treatment, pathological findings, and follow-up...
2016: Fetal and Pediatric Pathology
Julia K Shinnick, Heather L Short, Kurt F Heiss, Matthew T Santore, Martin L Blakely, Mehul V Raval
BACKGROUND: Enhanced recovery after surgery (ERAS), guidelines entail a strategy of perioperative management proven to hasten postoperative recovery and reduce complications in adult populations. Relatively few studies have investigated the applicability of this paradigm to pediatric populations. Our objective was to perform a systematic review of existing evidence regarding the use and efficacy of enhanced recovery protocols (ERPs) in the pediatric population. MATERIALS AND METHODS: Data were collected through a PubMed/MEDLINE literature search...
May 1, 2016: Journal of Surgical Research
Matthew T Santore, Saleem Islam
It is a fundamental value of the surgical profession to improve care for its patients. In the last 100 years, the principles of prospective quality improvement have started to work their way into the traditional method of retrospective case review in morbidity and mortality conference. This article summarizes the history of "improvement science" and its intersection with the field of surgery. It attempts to clarify the principles and jargon that may be new or confusing to surgeons with a different vocabulary and experience...
December 2015: Seminars in Pediatric Surgery
Avraham Schlager, Ragavan V Siddharthan, Matthew T Santore, Ozlem Balci, Matthew S Clifton, Kurt F Heiss
BACKGROUND: Total proctocolectomy (TPC) and ileal pouch anal anastomosis (IPAA) have become the standard of care for patients with ulcerative colitis refractory to medical management. The purpose of our study is to show our single-site approach and to identify maneuvers that improve efficiency. MATERIALS AND METHODS: We retrospectively reviewed patients who underwent single-site three-stage TPC-IPAA for ulcerative colitis at our institution. Primary outcomes included operative time, conversion from single site to standard laparoscopy, time to oral intake and stoma function, postoperative complications, and length of stay...
September 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Hanna Alemayehu, Matthew Clifton, Matthew Santore, Diana Diesen, Timothy Kane, Mikael Petrosyan, Ashanti Franklin, Dave Lal, Todd Ponsky, Margaret Nalugo, George W Holcomb, Shawn D St Peter
INTRODUCTION: The published experience with minimally invasive techniques to treat injured children is currently small. In this multicenter case series, we aimed to characterize the contemporary role of minimally invasive surgery (MIS) in pediatric trauma. MATERIALS AND METHODS: After obtaining Institutional Review Board approval at six pediatric regional trauma centers in the United States, a retrospective review was conducted on children who have undergone thoracoscopy or laparoscopy for the management of trauma over the past 13 years...
March 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Jesse D Vrecenak, Erik G Pearson, Matthew T Santore, Carlyn A Todorow, Haiying Li, Antoneta Radu, Tricia Bhatti, William H Peranteau, Mark P Johnson, Alan W Flake
Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a valid large animal model is needed prior to clinical application. The objective of this study was to establish clinically relevant levels of hematopoietic chimerism in a canine model of maternal-to-fetal IUHCT. We first assessed immune and hematopoietic ontogeny relevant to IUHCT in the canine model and identified 40 days' gestation (term 63 days) as a time point at the initiation of thymic selection, and prior to bone marrow hematopoiesis, that might be optimal for IUHCT...
September 18, 2014: Blood
Matthew T Santore, Katherine J Deans, Brittany J Behar, Thane A Blinman, N Scott Adzick, Alan W Flake
BACKGROUND: Laparoscopic surgical techniques have been applied for reconstruction after choledochal cyst resection. The aim of our study was to report the technical details of laparoscopic hepaticoduodenostomy and to compare outcomes between the open and laparoscopic approaches at our institution. METHODS: We performed a retrospective analysis of children with choledochal cyst who underwent hepaticoduodenostomy between August 2005 and May 2009. Patients were divided into open and laparoscopic groups based on the surgical approach...
May 2011: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Matthew T Santore, Brittany J Behar, Thane A Blinman, Edward J Doolin, Holly L Hedrick, Peter Mattei, Michael L Nance, N Scott Adzick, Alan W Flake
PURPOSE: Roux-en-Y hepaticojejunostomy (HJ) is currently the favored reconstructive procedure after resection of choledochal cysts. Hepaticoduodenostomy (HD) has been argued to be more physiologically and technically easier but is feared to have associated complications. Here we compare outcomes of the 2 procedures. METHODS: A retrospective chart review identified 59 patients who underwent choledochal cyst resection within our institution from 1999 to 2009. Demographic and outcome data were compared using t tests, Mann-Whitney U tests, and Pearson χ(2) tests...
January 2011: Journal of Pediatric Surgery
Miho Watanabe, Hiaying Li, Jessica Roybal, Matthew Santore, Antonetta Radu, Jun-Ichiro Jo, Michio Kaneko, Yasuhiko Tabata, Alan Flake
Myelomeningocele (MMC) is a common and devastating malformation. As an alternative to fetal surgical repair, tissue engineering has the potential to provide a less invasive approach for tissue coverage applicable at an earlier stage of gestation. We have previously evaluated the use of gelatin hydrogel composites composed of gelatin sponges and sheets as a platform for tissue coverage of the MMC defect in the retinoic acid induced fetal rat model of MMC. In the current study, we compare our previous composite with gelatin microspheres as a scaffold for tissue ingrowth and cellular adhesion within the amniotic fluid environment...
April 2011: Tissue Engineering. Part A
Cara C Bertozzi, Alec A Schmaier, Patricia Mericko, Paul R Hess, Zhiying Zou, Mei Chen, Chiu-Yu Chen, Bin Xu, Min-min Lu, Diane Zhou, Eric Sebzda, Matthew T Santore, Demetri J Merianos, Matthias Stadtfeld, Alan W Flake, Thomas Graf, Radek Skoda, Jonathan S Maltzman, Gary A Koretzky, Mark L Kahn
Although platelets appear by embryonic day 10.5 in the developing mouse, an embryonic role for these cells has not been identified. The SYK-SLP-76 signaling pathway is required in blood cells to regulate embryonic blood-lymphatic vascular separation, but the cell type and molecular mechanism underlying this regulatory pathway are not known. In the present study we demonstrate that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2 (CLEC-2) receptors...
July 29, 2010: Blood
Demetri J Merianos, Eleonor Tiblad, Matthew T Santore, Carlyn A Todorow, Pablo Laje, Masayuki Endo, Philip W Zoltick, Alan W Flake
The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment following in utero hematopoietic cell transplantation (IUHCT) in the murine model is reduced in allogeneic, compared with congenic, recipients. This observation supports the existence of an immune barrier to fetal transplantation and challenges the classic assumptions of fetal tolerance. Here, we present evidence that supports the presence of an adaptive immune response in murine recipients of IUHCT that failed to maintain engraftment...
September 2009: Journal of Clinical Investigation
Matthew T Santore, Jessica L Roybal, Alan W Flake
At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance...
June 2009: Clinics in Perinatology
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