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Matthew Santore

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https://www.readbyqxmd.com/read/27851192/1557-characteristics-and-predictors-of-intensive-care-unit-admission-in-pediatric-blunt-abdominal-trauma
#1
Adam Vogel, Robert Russell, Melvin Dassinger, Martin Blakely, Matthew Santore, Kuojen Tsao, Eunice Huang, Christian Streck
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27268154/the-vanishing-twin-syndrome-two-cases-of-extreme-malformations-associated-with-vanished-twins
#2
Julia K Shinnick, Nasim Khoshnam, Sydney R Archer, Philip C Quigley, Mark Robinson, Sarah Keene, Matthew T Santore, Sarah J Hill, Binita Patel, Bahig Shehata
Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35 year-old G1P0 woman and 36 year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. On histopathologic examination, the placentas demonstrated vascular anastomoses between the surviving co-twin and the "vanished" fetal sac...
June 6, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27257698/hepatic-and-splenic-blush-on-computed-tomography-in-children-following-blunt-abdominal-trauma-is-intervention-necessary
#3
Martha-Conley E Ingram, Ragavan V Siddharthan, Andrew D Morris, Sarah J Hill, Curtis D Travers, Courtney E McKracken, Kurt F Heiss, Mehul V Raval, Matthew T Santore
BACKGROUND: There are no widely accepted guidelines for management of pediatric patients who have evidence of solid organ contrast extravasation ("blush") on computed tomography (CT) scans following blunt abdominal trauma. We report our experience as a Level 1 pediatric trauma center in managing cases with hepatic and splenic blush. METHODS: All pediatric blunt abdominal trauma cases resulting in liver or splenic injury were queried from 2008 to 2014. Patients were excluded if a CT was unavailable in the medical record...
August 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27088671/congenital-cyst-of-the-pancreas-a-case-report-and-review-of-literature
#4
William T Warnock, Nasim Khoshnam, Kristin M Bird, Lauren R Schaffer, L H Lou, C Matthew Hawkins, Matthew T Santore, Sarah Hill, Anne E Gill, Pooya Hoseinzadeh, Bahig M Shehata
This is a case of a newborn female with congenital pancreatic cysts discovered incidentally. The 5-week-old infant had multiple abdominal cysts originating from the pancreas. When the radiologist catheter placement failed to alleviate the symptoms, the infant underwent laparoscopic excision. The lesion, however, recurred 11 months after the first excision, leading to a second surgical procedure including excision and marsupialization. A review of the literature revealed that this is a rare condition. Herein, we discuss the characteristics of the case, including medical imaging, drainage catheter placement, surgical treatment, pathological findings, and follow-up...
2016: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/27083963/enhancing-recovery-in-pediatric-surgery-a-review-of-the-literature
#5
REVIEW
Julia K Shinnick, Heather L Short, Kurt F Heiss, Matthew T Santore, Martin L Blakely, Mehul V Raval
BACKGROUND: Enhanced recovery after surgery (ERAS), guidelines entail a strategy of perioperative management proven to hasten postoperative recovery and reduce complications in adult populations. Relatively few studies have investigated the applicability of this paradigm to pediatric populations. Our objective was to perform a systematic review of existing evidence regarding the use and efficacy of enhanced recovery protocols (ERPs) in the pediatric population. MATERIALS AND METHODS: Data were collected through a PubMed/MEDLINE literature search...
May 1, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26653158/quality-improvement-101-for-surgeons-navigating-the-alphabet-soup
#6
Matthew T Santore, Saleem Islam
It is a fundamental value of the surgical profession to improve care for its patients. In the last 100 years, the principles of prospective quality improvement have started to work their way into the traditional method of retrospective case review in morbidity and mortality conference. This article summarizes the history of "improvement science" and its intersection with the field of surgery. It attempts to clarify the principles and jargon that may be new or confusing to surgeons with a different vocabulary and experience...
December 2015: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/26287392/single-incision-total-proctocolectomy-and-ileal-pouch-anal-anastomosis-in-pediatric-patients-lessons-learned
#7
Avraham Schlager, Ragavan V Siddharthan, Matthew T Santore, Ozlem Balci, Matthew S Clifton, Kurt F Heiss
BACKGROUND: Total proctocolectomy (TPC) and ileal pouch anal anastomosis (IPAA) have become the standard of care for patients with ulcerative colitis refractory to medical management. The purpose of our study is to show our single-site approach and to identify maneuvers that improve efficiency. MATERIALS AND METHODS: We retrospectively reviewed patients who underwent single-site three-stage TPC-IPAA for ulcerative colitis at our institution. Primary outcomes included operative time, conversion from single site to standard laparoscopy, time to oral intake and stoma function, postoperative complications, and length of stay...
September 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/25545146/minimally-invasive-surgery-for-pediatric-trauma-a-multicenter-review
#8
MULTICENTER STUDY
Hanna Alemayehu, Matthew Clifton, Matthew Santore, Diana Diesen, Timothy Kane, Mikael Petrosyan, Ashanti Franklin, Dave Lal, Todd Ponsky, Margaret Nalugo, George W Holcomb, Shawn D St Peter
INTRODUCTION: The published experience with minimally invasive techniques to treat injured children is currently small. In this multicenter case series, we aimed to characterize the contemporary role of minimally invasive surgery (MIS) in pediatric trauma. MATERIALS AND METHODS: After obtaining Institutional Review Board approval at six pediatric regional trauma centers in the United States, a retrospective review was conducted on children who have undergone thoracoscopy or laparoscopy for the management of trauma over the past 13 years...
March 2015: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/24869940/stable-long-term-mixed-chimerism-achieved-in-a-canine-model-of-allogeneic-in-utero-hematopoietic-cell-transplantation
#9
Jesse D Vrecenak, Erik G Pearson, Matthew T Santore, Carlyn A Todorow, Haiying Li, Antoneta Radu, Tricia Bhatti, William H Peranteau, Mark P Johnson, Alan W Flake
Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a valid large animal model is needed prior to clinical application. The objective of this study was to establish clinically relevant levels of hematopoietic chimerism in a canine model of maternal-to-fetal IUHCT. We first assessed immune and hematopoietic ontogeny relevant to IUHCT in the canine model and identified 40 days' gestation (term 63 days) as a time point at the initiation of thymic selection, and prior to bone marrow hematopoiesis, that might be optimal for IUHCT...
September 18, 2014: Blood
https://www.readbyqxmd.com/read/21443442/laparoscopic-hepaticoduodenostomy-versus-open-hepaticoduodenostomy-for-reconstruction-after-resection-of-choledochal-cyst
#10
COMPARATIVE STUDY
Matthew T Santore, Katherine J Deans, Brittany J Behar, Thane A Blinman, N Scott Adzick, Alan W Flake
BACKGROUND: Laparoscopic surgical techniques have been applied for reconstruction after choledochal cyst resection. The aim of our study was to report the technical details of laparoscopic hepaticoduodenostomy and to compare outcomes between the open and laparoscopic approaches at our institution. METHODS: We performed a retrospective analysis of children with choledochal cyst who underwent hepaticoduodenostomy between August 2005 and May 2009. Patients were divided into open and laparoscopic groups based on the surgical approach...
May 2011: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/21238669/hepaticoduodenostomy-vs-hepaticojejunostomy-for-reconstruction-after-resection-of-choledochal-cyst
#11
COMPARATIVE STUDY
Matthew T Santore, Brittany J Behar, Thane A Blinman, Edward J Doolin, Holly L Hedrick, Peter Mattei, Michael L Nance, N Scott Adzick, Alan W Flake
PURPOSE: Roux-en-Y hepaticojejunostomy (HJ) is currently the favored reconstructive procedure after resection of choledochal cysts. Hepaticoduodenostomy (HD) has been argued to be more physiologically and technically easier but is feared to have associated complications. Here we compare outcomes of the 2 procedures. METHODS: A retrospective chart review identified 59 patients who underwent choledochal cyst resection within our institution from 1999 to 2009. Demographic and outcome data were compared using t tests, Mann-Whitney U tests, and Pearson χ(2) tests...
January 2011: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/21128864/a-tissue-engineering-approach-for-prenatal-closure-of-myelomeningocele-comparison-of-gelatin-sponge-and-microsphere-scaffolds-and-bioactive-protein-coatings
#12
Miho Watanabe, Hiaying Li, Jessica Roybal, Matthew Santore, Antonetta Radu, Jun-Ichiro Jo, Michio Kaneko, Yasuhiko Tabata, Alan Flake
Myelomeningocele (MMC) is a common and devastating malformation. As an alternative to fetal surgical repair, tissue engineering has the potential to provide a less invasive approach for tissue coverage applicable at an earlier stage of gestation. We have previously evaluated the use of gelatin hydrogel composites composed of gelatin sponges and sheets as a platform for tissue coverage of the MMC defect in the retinoic acid induced fetal rat model of MMC. In the current study, we compare our previous composite with gelatin microspheres as a scaffold for tissue ingrowth and cellular adhesion within the amniotic fluid environment...
April 2011: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/20363774/platelets-regulate-lymphatic-vascular-development-through-clec-2-slp-76-signaling
#13
Cara C Bertozzi, Alec A Schmaier, Patricia Mericko, Paul R Hess, Zhiying Zou, Mei Chen, Chiu-Yu Chen, Bin Xu, Min-min Lu, Diane Zhou, Eric Sebzda, Matthew T Santore, Demetri J Merianos, Matthias Stadtfeld, Alan W Flake, Thomas Graf, Radek Skoda, Jonathan S Maltzman, Gary A Koretzky, Mark L Kahn
Although platelets appear by embryonic day 10.5 in the developing mouse, an embryonic role for these cells has not been identified. The SYK-SLP-76 signaling pathway is required in blood cells to regulate embryonic blood-lymphatic vascular separation, but the cell type and molecular mechanism underlying this regulatory pathway are not known. In the present study we demonstrate that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2 (CLEC-2) receptors...
July 29, 2010: Blood
https://www.readbyqxmd.com/read/19652363/maternal-alloantibodies-induce-a-postnatal-immune-response-that-limits-engraftment-following-in-utero-hematopoietic-cell-transplantation-in-mice
#14
Demetri J Merianos, Eleonor Tiblad, Matthew T Santore, Carlyn A Todorow, Pablo Laje, Masayuki Endo, Philip W Zoltick, Alan W Flake
The lack of fetal immune responses to foreign antigens, i.e., fetal immunologic tolerance, is the most compelling rationale for prenatal stem cell and gene therapy. However, the frequency of engraftment following in utero hematopoietic cell transplantation (IUHCT) in the murine model is reduced in allogeneic, compared with congenic, recipients. This observation supports the existence of an immune barrier to fetal transplantation and challenges the classic assumptions of fetal tolerance. Here, we present evidence that supports the presence of an adaptive immune response in murine recipients of IUHCT that failed to maintain engraftment...
September 2009: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/19559331/prenatal-stem-cell-transplantation-and-gene-therapy
#15
REVIEW
Matthew T Santore, Jessica L Roybal, Alan W Flake
At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance...
June 2009: Clinics in Perinatology
https://www.readbyqxmd.com/read/19540822/stem-cell-and-genetic-therapies-for-the-fetus
#16
REVIEW
Jessica L Roybal, Matthew T Santore, Alan W Flake
Advances in prenatal diagnosis have led to the prenatal management of a variety of congenital diseases. Although prenatal stem cell and gene therapy await clinical application, they offer tremendous potential for the treatment of many genetic disorders. Normal developmental events in the fetus offer unique biologic advantages for the engraftment of hematopoietic stem cells and efficient gene transfer that are not present after birth. Although barriers to hematopoietic stem cell engraftment exist, progress has been made and preclinical studies are now underway for strategies based on prenatal tolerance induction to facilitate postnatal cellular transplantation...
February 2010: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/16100116/apbp-1-a-dna-rna-binding-protein-interacts-with-the-chick-aggrecan-regulatory-region
#17
Edward W Pirok, Miriam S Domowicz, Judith Henry, Youli Wang, Matthew Santore, Melissa M Mueller, Nancy B Schwartz
Expression of the extracellular proteoglycan aggrecan is both cell-specific and developmentally regulated. Previous studies identified six functionally defined cis elements in the aggrecan promoter region which were shown to repress aggrecan gene expression (1). Using competition electrophoretic mobility shift assays (EMSAs) we have now identified in nuclear extracts a functional repressor cis element, (T/C)TCCCCT(A/C)RRC, which occurs at multiple locations within the chick aggrecan regulatory region. We purified the factor that binds to this cis element and established that it, APBP-1 (aggrecan promoter-binding protein-1), is a 19-kDa protein that has significant homology to CIRP (cold inducible RNA-binding protein)...
October 21, 2005: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/14700295/primary-insertion-of-a-silastic-spring-loaded-silo-for-gastroschisis
#18
MULTICENTER STUDY
Yeming Wu, Adam M Vogel, Elizabeth A Sailhamer, Stig Somme, Matthew J Santore, Walter J Chwals, Mindy B Statter, Donald C Liu
Gastroschisis is traditionally managed by emergency primary closure, with a temporary silo reserved for large defects unable to be closed primarily. We recently have begun primary Silastic (Dow Coming, Midland, MI) spring-loaded silo (SLS) closure followed by elective closure and report our preliminary experience. A total of 15 infants (weight range, 2.1-13.5 kg) at 2 different institutions were treated by SC by 3 different surgeons between 1998 and 2002. A 3-, 4-, or 5-cm (ring diameter) silo was used depending on size of abdominal wall defect...
December 2003: American Surgeon
https://www.readbyqxmd.com/read/14627695/c-myc-sensitization-to-oxygen-deprivation-induced-cell-death-is-dependent-on-bax-bak-but-is-independent-of-p53-and-hypoxia-inducible-factor-1
#19
Joslyn K Brunelle, Matthew T Santore, G R Scott Budinger, Yueming Tang, Terrence A Barrett, Wei-Xing Zong, Eugene Kandel, Brian Keith, M Celeste Simon, Craig B Thompson, Nissim Hay, Navdeep S Chandel
Deregulated expression of c-Myc can sensitize cells to a variety of death stimuli, including loss of growth factors and oxygen. In this study, we examined whether rodent fibroblasts that conditionally express c-Myc undergo a similar mechanism of cell death in response to serum or oxygen deprivation. Our results demonstrate that murine embryonic fibroblasts from bax-/-bak-/- mice that conditionally express c-Myc did not die in response to either oxygen or serum deprivation. Fibroblasts from p53-/- mice that conditionally express c-Myc died in response to oxygen (but not serum) deprivation...
February 6, 2004: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/12852517/hepatectomy-in-children-under-total-hepatic-occlusion
#20
Donald C Liu, Adam M Vogel, Seza Gulec, Matthew J Santore, Yeming Wu, Charles B Hill
Major ablative hepatic resection is often indicated in children with solid liver tumors, and reduction of operative blood transfusion is a primary goal. Total hepatic occlusion (THO) is an effective method that is well established in adults, yet its role in children is less well described. We describe our preliminary experience with THO in children assessing surgical outcome. The charts of seven children (ages 5 months to 7 years, weight 6-30 kg) who underwent THO during hepatectomy (four right and three left lobectomies) for liver tumors (hepatoblastoma in three, metastatic Wilm's tumor in two, mesenchymal hamartoma in one, and angiosarcoma in one) between January 1997 and June 2002 were reviewed...
June 2003: American Surgeon
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