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Jonathan Meisel

Erik P Hess, Judd E Hollander, Jason T Schaffer, Jeffrey A Kline, Carlos A Torres, Deborah B Diercks, Russell Jones, Kelly P Owen, Zachary F Meisel, Michel Demers, Annie Leblanc, Nilay D Shah, Jonathan Inselman, Jeph Herrin, Ana Castaneda-Guarderas, Victor M Montori
OBJECTIVE:  To compare the effectiveness of shared decision making with usual care in choice of admission for observation and further cardiac testing or for referral for outpatient evaluation in patients with possible acute coronary syndrome. DESIGN:  Multicenter pragmatic parallel randomized controlled trial. SETTING:  Six emergency departments in the United States. PARTICIPANTS:  898 adults (aged >17 years) with a primary complaint of chest pain who were being considered for admission to an observation unit for cardiac testing (451 were allocated to the decision aid and 447 to usual care), and 361 emergency clinicians (emergency physicians, nurse practitioners, and physician assistants) caring for patients with chest pain...
December 5, 2016: BMJ: British Medical Journal
Joshua Quick, Nicholas J Loman, Sophie Duraffour, Jared T Simpson, Ettore Severi, Lauren Cowley, Joseph Akoi Bore, Raymond Koundouno, Gytis Dudas, Amy Mikhail, Nobila Ouédraogo, Babak Afrough, Amadou Bah, Jonathan H J Baum, Beate Becker-Ziaja, Jan Peter Boettcher, Mar Cabeza-Cabrerizo, Álvaro Camino-Sánchez, Lisa L Carter, Juliane Doerrbecker, Theresa Enkirch, Isabel García-Dorival, Nicole Hetzelt, Julia Hinzmann, Tobias Holm, Liana Eleni Kafetzopoulou, Michel Koropogui, Abigael Kosgey, Eeva Kuisma, Christopher H Logue, Antonio Mazzarelli, Sarah Meisel, Marc Mertens, Janine Michel, Didier Ngabo, Katja Nitzsche, Elisa Pallasch, Livia Victoria Patrono, Jasmine Portmann, Johanna Gabriella Repits, Natasha Y Rickett, Andreas Sachse, Katrin Singethan, Inês Vitoriano, Rahel L Yemanaberhan, Elsa G Zekeng, Trina Racine, Alexander Bello, Amadou Alpha Sall, Ousmane Faye, Oumar Faye, N'Faly Magassouba, Cecelia V Williams, Victoria Amburgey, Linda Winona, Emily Davis, Jon Gerlach, Frank Washington, Vanessa Monteil, Marine Jourdain, Marion Bererd, Alimou Camara, Hermann Somlare, Abdoulaye Camara, Marianne Gerard, Guillaume Bado, Bernard Baillet, Déborah Delaune, Koumpingnin Yacouba Nebie, Abdoulaye Diarra, Yacouba Savane, Raymond Bernard Pallawo, Giovanna Jaramillo Gutierrez, Natacha Milhano, Isabelle Roger, Christopher J Williams, Facinet Yattara, Kuiama Lewandowski, James Taylor, Phillip Rachwal, Daniel J Turner, Georgios Pollakis, Julian A Hiscox, David A Matthews, Matthew K O'Shea, Andrew McD Johnston, Duncan Wilson, Emma Hutley, Erasmus Smit, Antonino Di Caro, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Martin Gabriel, Simon A Weller, Lamine Koivogui, Boubacar Diallo, Sakoba Keïta, Andrew Rambaut, Pierre Formenty, Stephan Günther, Miles W Carroll
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is desirable to characterize the infectious agent and determine its evolutionary rate. Genome sequencing also allows the identification of signatures of host adaptation, identification and monitoring of diagnostic targets, and characterization of responses to vaccines and treatments. The Ebola virus (EBOV) genome substitution rate in the Makona strain has been estimated at between 0...
February 11, 2016: Nature
Nadia E Saldanha, Jonathan A Meisel, Jose M Prince, Ronald Feinstein, Martin Fisher
Anorexia nervosa is a medical and psychological disorder classically seen in young women who present with significant weight loss, a distorted body image, and an intense fear of gaining weight despite being underweight. A rare diagnosis that is also associated with weight loss is a trichobezoar, a collection of hair or hair-like fibers in the gastrointestinal tract, primarily in the stomach. In this report, we present the case of a 14.5-year-old girl with weight loss caused by a trichobezoar, initially thought to be due to anorexia nervosa, and we review the details of both disorders...
August 2015: International Journal of Adolescent Medicine and Health
Alexander H Nave, Jan M Kröber, Peter Brunecker, Jochen B Fiebach, Jonathan List, Ulrike Grittner, Matthias Endres, Andreas Meisel, Agnes Flöel, Martin Ebinger
BACKGROUND: Physical activity is believed to exert a beneficial effect on functional and cognitive rehabilitation of patients with stroke. Although studies have addressed the impact of physical exercise in cerebrovascular prevention and rehabilitation, the underlying mechanisms leading to improvement are poorly understood. Training-induced increase of cerebral perfusion is a possible mediating mechanism. Our exploratory study aims to investigate training-induced changes in blood biomarker levels and magnetic resonance imaging in patients with subacute ischemic stroke...
December 11, 2013: BMC Neurology
Ignazio Verde, Albert G Abbott, Simone Scalabrin, Sook Jung, Shengqiang Shu, Fabio Marroni, Tatyana Zhebentyayeva, Maria Teresa Dettori, Jane Grimwood, Federica Cattonaro, Andrea Zuccolo, Laura Rossini, Jerry Jenkins, Elisa Vendramin, Lee A Meisel, Veronique Decroocq, Bryon Sosinski, Simon Prochnik, Therese Mitros, Alberto Policriti, Guido Cipriani, Luca Dondini, Stephen Ficklin, David M Goodstein, Pengfei Xuan, Cristian Del Fabbro, Valeria Aramini, Dario Copetti, Susana Gonzalez, David S Horner, Rachele Falchi, Susan Lucas, Erica Mica, Jonathan Maldonado, Barbara Lazzari, Douglas Bielenberg, Raul Pirona, Mara Miculan, Abdelali Barakat, Raffaele Testolin, Alessandra Stella, Stefano Tartarini, Pietro Tonutti, Pere Arús, Ariel Orellana, Christina Wells, Dorrie Main, Giannina Vizzotto, Herman Silva, Francesco Salamini, Jeremy Schmutz, Michele Morgante, Daniel S Rokhsar
Rosaceae is the most important fruit-producing clade, and its key commercially relevant genera (Fragaria, Rosa, Rubus and Prunus) show broadly diverse growth habits, fruit types and compact diploid genomes. Peach, a diploid Prunus species, is one of the best genetically characterized deciduous trees. Here we describe the high-quality genome sequence of peach obtained from a completely homozygous genotype. We obtained a complete chromosome-scale assembly using Sanger whole-genome shotgun methods. We predicted 27,852 protein-coding genes, as well as noncoding RNAs...
May 2013: Nature Genetics
Hau D Le, Erica M Fallon, Brian T Kalish, Vincent E de Meijer, Jonathan A Meisel, Kathleen M Gura, Vania Nose, Amy H Pan, Bruce R Bistrian, Mark Puder
OBJECTIVE: Essential fatty acids (EFA) are necessary for growth, development, and biological function, and must be acquired through the diet. While linoleic acid (LA) and alpha-linolenic acid (ALA) have been considered the true EFAs, we previously demonstrated that docosahexaenoic acid (DHA) and arachidonic acid (AA) taken together as the sole source of dietary fatty acids can prevent biochemical essential fatty acid deficiency (EFAD). This study evaluates the effect of varying dietary ratios of DHA:AA in the prevention and reversal of biochemical EFAD in a murine model...
April 2013: Metabolism: Clinical and Experimental
Erica M Fallon, Paul D Mitchell, Alexis K Potemkin, Deepika Nehra, Danielle A Arsenault, Elizabeth M Robinson, David Zurakowski, Megan Brenn, Jonathan A Meisel, Mark Puder
PURPOSE: The aim of this study was to determine the incidence of cholestasis and the correlation between cholestasis and weight-for-age z scores in parenteral nutrition-dependent neonates with gastroschisis. METHODS: A single-center retrospective review of 59 infants born with gastroschisis from January 2000 to June 2007 was conducted. Demographic and clinical data were collected and analyzed. Subjects were divided into cholestatic and noncholestatic groups. Statistical analyses included the Student t test, Wilcoxon rank sum test, Fisher exact test, and a general linear model...
August 2012: Journal of Pediatric Surgery
Vincent E de Meijer, Brian T Kalish, Jonathan A Meisel, Hau D Le, Mark Puder
BACKGROUND: Paracetamol (APAP) hepatotoxicity remains the leading cause of drug-induced liver failure. Fish oil, which contains ω-3 fatty acids, has demonstrated therapeutic efficacy in several models of liver disease. Evidence for its use in APAP intoxication, however, is conflicting. The effects of fish oil supplementation on APAP-induced liver failure were investigated. METHODS: Ten C57BL6/J mice were fed a diet based on menhaden fish oil (MEN) or soybean oil (SOY) for 3 weeks followed by APAP intoxication...
March 2013: JPEN. Journal of Parenteral and Enteral Nutrition
Hau D Le, Jonathan A Meisel, Vincent E de Meijer, Erica M Fallon, Kathleen M Gura, Vania Nose, Bruce R Bistrian, Mark Puder
OBJECTIVES: Essential fatty acids are important for growth, development, and physiologic function. α-Linolenic acid and linoleic acid are the precursors of docosahexaenoic and arachidonic acid, respectively, and have traditionally been considered the essential fatty acids. However, the authors hypothesized that docosahexaenoic acid and arachidonic acid can function as the essential fatty acids. METHODS: Using a murine model of essential fatty acid deficiency and consequent hepatic steatosis, the authors provided mice with varying amounts of docosahexaenoic and arachidonic acids to determine whether exclusive supplementation of docosahexaenoic and arachidonic acids could prevent essential fatty acid deficiency and inhibit or attenuate hepatic steatosis...
July 2012: JPEN. Journal of Parenteral and Enteral Nutrition
Vincent E de Meijer, Hau D Le, Jonathan A Meisel, Anisha K Sharma, Yury Popov, Mark Puder
BACKGROUND: Hepatic steatosis is an established risk factor for complications following major hepatic resection. Pharmacological options to reverse steatosis prior to surgery, however, are lacking. We hypothesized that treatment with the pharmacologic tumor necrosis factor-α converting enzyme (TACE)-inhibitor Marimastat would reverse established steatosis, leading to improved outcome following hepatectomy. METHODOLOGY/PRINCIPAL FINDINGS: C57BL/6 male mice were fed a high fat diet for 9 weeks to establish obesity, hepatic steatosis and insulin resistance, and were administered either Marimastat or vehicle for an additional 2 or 4 weeks...
2011: PloS One
Jonathan A Meisel, Erica M Fallon, Hau D Le, Deepika Nehra, Vincent E de Meijer, Scott J Rodig, Mark Puder
BACKGROUND: Postoperative abdominal adhesions are a major cause of morbidity and mortality. We previously demonstrated the inhibitory effect of sunitinib, a receptor tyrosine kinase inhibitor, on adhesion formation in a murine model, and now investigate its effects in a rabbit model. METHODS: Forty New Zealand White rabbits underwent a standard adhesion procedure. Preoperatively, animals were randomized to treatment with sunitinib or saline (control). Animals were treated with a total of 11 daily doses, 1 preoperative and 10 postoperative...
July 2011: Surgery
Jonathan A Meisel, Hau D Le, Vincent E de Meijer, Vania Nose, Kathleen M Gura, Robert V Mulkern, M Reza Akhavan Sharif, Mark Puder
BACKGROUND: Plant-based intravenous lipid emulsions have been shown to contribute to parenteral nutrition-associated liver disease (PNALD). There is mounting evidence that fish oil-based emulsions may prevent this liver injury. This study compares 5 emulsions with different fat compositions and their effect on hepatic steatosis, one of the first hits in PNALD. METHODS: C57BL/6J mice were placed on a fat-free diet and randomized into 5 equal groups. Each group received one of the commercially available intravenous lipid emulsions (Intralipid [Baxter/Fresenius Kabi, Deerfield, Ill], Liposyn II [Hospira Inc, Lake Forest, Ill], ClinOleic [Baxter/Clintec Parenteral SA, Cedex, France], SMOFlipid [Fresenius Kabi, Bad Homburg, Germany], or Omegaven [Fresenius Kabi Deutschland GmbH]) or normal saline...
April 2011: Journal of Pediatric Surgery
Hau D Le, Vincent E de Meijer, David Zurakowski, Jonathan A Meisel, Kathleen M Gura, Mark Puder
BACKGROUND: Parenteral nutrition (PN) is a life-saving therapy but has been associated with dyslipidemia. Because fish oil has been shown to have positive effects on lipid profiles, the authors hypothesize that a parenteral fish oil lipid emulsion will improve lipid profiles in children who are PN dependent. METHODS: The authors examined the lipid profiles of a unique cohort of 10 children who were exclusively administered a fish oil-based lipid emulsion while on PN for a median duration of 14 weeks...
September 2010: JPEN. Journal of Parenteral and Enteral Nutrition
Vincent E de Meijer, Deanna Y Sverdlov, Yury Popov, Hau D Le, Jonathan A Meisel, Vânia Nosé, Detlef Schuppan, Mark Puder
BACKGROUND: Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammation is considered a prerequisite and important co-contributor to fibrosis and is, in part, mediated by tumor necrosis factor (TNF)-alpha-converting enzyme (TACE). We hypothesized that treatment with a broad-spectrum MMP and TACE-inhibitor (Marimastat) would ameliorate injury and inflammation, leading to decreased fibrogenesis during repeated hepatotoxin-induced liver injury...
June 25, 2010: PloS One
Vincent E de Meijer, Kathleen M Gura, Jonathan A Meisel, Hau D Le, Mark Puder
OBJECTIVES: To update knowledge on the management of parenteral nutrition-associated liver disease (PNALD) and to review the clinical data on the use of parenteral fish oil for reversal of PNALD. DATA SOURCES: A literature review was conducted by searching the MEDLINE database (May 1, 2009) using the keywords parenteral nutrition-associated liver disease, fish oil, omega-3, Omegaven, and lipid emulsion. STUDY SELECTION: All articles reporting clinical cases with the use of parenteral fish oil for management of PNALD...
June 2010: Archives of Surgery
Vincent E de Meijer, Hau D Le, Jonathan A Meisel, Mark Puder
Interest in pharmacological intervention to combat metabolic syndrome and its complications is increasing as the prevalence of obesity is reaching epidemic proportions. The potential efficacy of drugs is often tested in animal models; however, the method of drug delivery is frequently overlooked and may act as a confounder due to stress. We hypothesized that long-term orogastric gavage would negatively influence the development of hepatic steatosis and the metabolic syndrome in a murine model of diet-induced obesity...
June 16, 2010: Physiology & Behavior
Vincent E de Meijer, Hau D Le, Jonathan A Meisel, M Reza Akhavan Sharif, Amy Pan, Vânia Nosé, Mark Puder
Nonalcoholic fatty liver disease results from overconsumption and is a significant and increasing cause of liver failure. The type of diet that is conducive to the development of this disease has not been established, and evidence-based treatment options are currently lacking. We hypothesized that the onset of hepatic steatosis is linked to the consumption of a diet with a high fat content, rather than related to excess caloric intake. In addition, we also hypothesized that fully manifested hepatic steatosis could be reversed by reducing the fat percentage in the diet of obese mice...
August 2010: Metabolism: Clinical and Experimental
Vincent E de Meijer, Hau D Le, Jonathan A Meisel, Kathleen M Gura, Mark Puder
OBJECTIVE: The use of fish oil-based emulsions as the sole source of fat for patients receiving parenteral nutrition (PN) has raised concerns for the development of essential fatty acid deficiency (EFAD), hindering its adoption into clinical practice. The purpose of the present study was to examine fatty acid profiles of patients receiving no enteral energy, while completely dependent on PN and an intravenous fish oil-based lipid emulsion, for onset of EFAD and maintenance of growth. PATIENTS AND METHODS: Prospectively collected data from 10 patients were reviewed for evidence of EFAD, defined as a triene:tetraene ratio >0...
February 2010: Journal of Pediatric Gastroenterology and Nutrition
Paula Vizoso, Lee A Meisel, Andrés Tittarelli, Mariano Latorre, Juan Saba, Rodrigo Caroca, Jonathan Maldonado, Veronica Cambiazo, Reinaldo Campos-Vargas, Mauricio Gonzalez, Ariel Orellana, Herman Silva
BACKGROUND: Cold storage is used to inhibit peach fruit ripening during shipment to distant markets. However, this cold storage can negatively affect the quality of the fruit when it is ripened, resulting in disorders such as wooliness, browning or leathering. In order to understand the individual and combined biological effects that factors such as cold storage and ripening have on the fruit and fruit quality, we have taken a comparative EST transcript profiling approach to identify genes that are differentially expressed in response to these factors...
2009: BMC Genomics
Sang I Lee, Clarissa Valim, Patrick Johnston, Hau D Le, Jonathan Meisel, Danielle A Arsenault, Kathleen M Gura, Mark Puder
Parenteral nutrition is known to cause liver injury in babies. The aim of this study is to investigate the effects of different lipid emulsions on parenteral nutrition-associated cholestasis in infants. In addition, there may be a relationship between the lipid emulsion and triglyceride levels. Furthermore, triglyceride levels may correlate with direct bilirubin and albumin, as markers of liver impairment and nutritional status. Patients with parenteral nutrition-associated cholestasis who were treated with a fish oil-based lipid emulsion (n = 18) were prospectively followed for triglyceride, direct bilirubin, and albumin levels and compared with patients who were maintained on a soy-based lipid emulsion (n = 59)...
December 2009: Pediatric Research
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