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JOURNAL ARTICLE
Timothy L Arleo, Rachel F Swerdlin, Anne E Gill, Steven L Goudy, Jonathan A Meisel, Michael A Briones, Jay H Shah, Allyson Wright, Clifford Matthew Hawkins
OBJECTIVE: The aim of this study was to quantify and describe baseline patient and parent-proxy health-related quality of life scores in patients with low-flow vascular malformations at a single, tertiary-care vascular anomalies clinic. STUDY DESIGN: This is a retrospective study of data collected on patients with low-flow vascular malformations between the ages of 2 to 25 who were seen at a single, tertiary-care center vascular anomalies clinic. A total of 266 patients are included in this study...
August 4, 2023: Journal of Pediatric Hematology/oncology
#2
JOURNAL ARTICLE
Matthew P Abrams, Arthur P Pelullo, Zachary F Meisel, Raina M Merchant, Jonathan Purtle, Anish K Agarwal
BACKGROUND: Burnout and the mental health burden of the COVID-19 pandemic have disproportionately impacted health care workers. The links between state policies, federal regulations, COVID-19 case counts, strains on health care systems, and the mental health of health care workers continue to evolve. The language used by state and federal legislators in public-facing venues such as social media is important, as it impacts public opinion and behavior, and it also reflects current policy-leader opinions and planned legislation...
2023: JMIR Infodemiology
#3
RANDOMIZED CONTROLLED TRIAL
Roxanne Dupuis, Rachel Feuerstein-Simon, Terri F Brown-Whitehorn, Jonathan M Spergel, Kevin G Volpp, Xochitl Luna Marti, Andrea B Troxel, Zachary F Meisel, Cynthia J Mollen, Erica L Kenney, Jason Block, Steven L Gortmaker, Carolyn C Cannuscio
OBJECTIVE: We sought to evaluate the use of behavioral economics approaches to promote the carrying of epinephrine auto-injectors (EAIs) among adolescents with food allergies. We hypothesized that adolescents who receive frequent text message nudges (Intervention 1) or frequent text message nudges plus modest financial incentives (Intervention 2) would be more likely to carry their epinephrine than members of the usual care control group. METHODS: We recruited 131 adolescents ages 15 to 19 with a food allergy and a current prescription for epinephrine to participate in a cohort multiple randomized controlled trial...
February 1, 2023: Pediatrics
#4
JOURNAL ARTICLE
Basilio Carrasco, Bárbara Arévalo, Ricardo Perez-Diaz, Yohaily Rodríguez-Alvarez, Marlene Gebauer, Jonathan E Maldonado, Rolando García-Gonzáles, Borys Chong-Pérez, José Pico-Mendoza, Lee A Meisel, Ray Ming, Herman Silva
A genotyping by sequencing (GBS) approach was used to analyze the organization of genetic diversity in V. pubescens and V. chilensis. GBS identified 4675 and 4451 SNPs/INDELs in two papaya species. The cultivated orchards of V. pubescens exhibited scarce genetic diversity and low but significant genetic differentiation. The neutrality test yielded a negative and significant result, suggesting that V. pubescens suffered a selective sweep or a rapid expansion after a bottleneck during domestication. In contrast, V...
August 18, 2022: Plants (Basel, Switzerland)
#5
JOURNAL ARTICLE
Nathalie Kuhn, Jonathan Maldonado, Claudio Ponce, Macarena Arellano, Alson Time, Salvatore Multari, Stefan Martens, Esther Carrera, José Manuel Donoso, Boris Sagredo, Lee A Meisel
Gibberellin (GA) negatively affects color evolution and other ripening-related processes in non-climacteric fruits. The bioactive GA, gibberellic acid (GA3 ), is commonly applied at the light green-to-straw yellow transition to increase firmness and delay ripening in sweet cherry (Prunus avium L.), though causing different effects depending on the variety. Recently, we reported that GA3 delayed the IAD parameter (a ripening index) in a mid-season variety, whereas GA3 did not delay IAD but reduced it at ripeness in an early-season variety...
June 22, 2021: Scientific Reports
#6
JOURNAL ARTICLE
Eden Engel-Rebitzer, Daniel Camargo Stokes, Alison Buttenheim, Jonathan Purtle, Zachary F Meisel
Widespread SARS-CoV-2 vaccine uptake will be critical to resolution of the COVID-19 pandemic. Politicians have the potential to impact vaccine sentiment and uptake through vaccine-related communication with the public. We used tweets (n = 6,201), abstracted from Quorum, a public affairs software platform, to examine changes in the frequency of vaccine-related communication by legislators on the social media platform, Twitter. We found an increase in vaccine-related tweets by legislators following the arrival of SARS-CoV-2 in the United States...
May 10, 2021: Human Vaccines & Immunotherapeutics
#7
JOURNAL ARTICLE
Sharath Chandra Guntuku, Jonathan Purtle, Zachary F Meisel, Raina M Merchant, Anish Agarwal
BACKGROUND: As policy makers continue to shape the national and local responses to the COVID-19 pandemic, information they choose to share, and how they frame their content provides key insights to the public and healthcare systems. OBJECTIVE: We examine the language used by the members of the U.S. House and Senate during the first ten months of the COVID-19 pandemic, measuring the content and sentiment based on the tweets they shared. METHODS: We used Quorum to access more than 300,000 tweets posted by U...
April 16, 2021: Journal of Medical Internet Research
#8
JOURNAL ARTICLE
Eshcar Meisel, Orly Efros, Jonathan Bleier, Tal Beit Halevi, Gad Segal, Galia Rahav, Avshalom Leibowitz, Ehud Grossman
We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic signifi-cance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Thirty-eight (11...
March 2, 2021: Nutrients
#9
JOURNAL ARTICLE
Daniel C Stokes, Jonathan Purtle, Zachary F Meisel, Anish K Agarwal
BACKGROUND: The opioid epidemic is widely recognized as a legislative priority, but there is substantial variation in state adoption of evidence-based policy. State legislators' use of social media to disseminate information and to indicate support for specific initiatives continues to grow and may reflect legislators' openness to opioid-related policy change. OBJECTIVE: We sought to identify changes in the national dialogue regarding the opioid epidemic among Democratic and Republican state legislators and to estimate changing partisanship around understanding and addressing the epidemic over time...
March 29, 2021: Journal of General Internal Medicine
#10
JOURNAL ARTICLE
Elizabeth M Sinclair, James P Stevens, Barbara McElhanon, Jonathan A Meisel, Matthew T Santore, A Alfred Chahine, Erica L Riedesel
Background: Complications from esophageal button battery impactions remain a real fear for practicing pediatric gastroenterologists and surgeons. This case describes a child who developed an aorto-esophageal fistula 25 days after initial battery ingestion and survived due to prompt placement of an aortic stent via minimally invasive surgery, avoiding an open procedure. Case presentation: A 6-year-old female presented acutely with a mid-esophageal button battery impaction witnessed by her parents...
March 2021: Journal of Pediatric Surgery Case Reports
#11
JOURNAL ARTICLE
Sharon Chiang, Robert Moss, Angela P Black, Michele Jackson, Chuck Moss, Jonathan Bidwell, Christian Meisel, Tobias Loddenkemper
Objective: Seizure forecasting algorithms have become increasingly accurate and may reduce the morbidity and mortality caused by seizure unpredictability. Translating these benefits into meaningful health outcomes for people with epilepsy requires effective data visualization of algorithm outputs. To date, no studies have investigated patient and physician perspectives on effective translation of algorithm outputs into data visualizations through health information technology. Materials and Methods: We developed front-end data visualizations as part of a Seizure Forecast Visualization Toolkit...
January 2021: JAMIA Open
#12
JOURNAL ARTICLE
Romy Kerber, Eva Lorenz, Sophie Duraffour, Daouda Sissoko, Martin Rudolf, Anna Jaeger, Sekou Ditinn Cisse, Alseny-Modet Camara, Osvaldo Miranda, Carlos M Castro, Joseph Akoi Bore, Fara Raymond Koundouno, Johanna Repits, Babak Afrough, Beate Becker-Ziaja, Julia Hinzmann, Marc Mertens, Ines Vitoriano, Christopher Hugh Logue, Jan-Peter Böttcher, Elisa Pallasch, Andreas Sachse, Amadou Bah, Mar Cabeza-Cabrerizo, Katja Nitzsche, Eeva Kuisma, Janine Michel, Tobias Holm, Elsa Gayle Zekeng, Lauren A Cowley, Isabel Garcia-Dorival, Nicole Hetzelt, Jonathan Hans Josef Baum, Jasmine Portmann, Lisa Carter, Rahel Lemma Yenamaberhan, Alvaro Camino, Theresa Enkirch, Katrin Singethan, Sarah Meisel, Antonio Mazzarelli, Abigail Kosgei, Liana Kafetzopoulou, Natasha Y Rickett, Livia Victoria Patrono, Luam Ghebreghiorghis, Ulrike Arnold, Géraldine Colin, Sylvain Juchet, Claire Levy Marchal, Jacques Seraphin Kolie, Abdoul Habib Beavogui, Stephanie Wurr, Sabrina Bockholt, Ralf Krumkamp, Jürgen May, Kilian Stoecker, Erna Fleischmann, Giuseppe Ippolito, Miles W Carroll, Lamine Koivogui, N'Faly Magassouba, Sakoba Keita, Céline Gurry, Patrick Drury, Boubacar Diallo, Pierre Formenty, Roman Wölfel, Antonino Di Caro, Martin Gabriel, Xavier Anglaret, Denis Malvy, Stephan Günther
BACKGROUND: In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus-specific reverse transcription-polymerase chain reaction assay and 13 blood chemistry parameters were measured on admission and during hospitalization. Favipiravir treatment was offered to patients with EVD on a compassionate-use basis. METHODS: To reduce biases in the raw field data, we carefully selected 163 of 286 patients with EVD for a retrospective study to assess associations between potential risk factors, alterations in blood chemistry findings, favipiravir treatment, and outcome...
June 19, 2019: Journal of Infectious Diseases
#13
JOURNAL ARTICLE
Jonathan Maldonado, Amit Dhingra, Basilio Carrasco, Lee Meisel, Herman Silva
Sweet cherry fruits from different cultivars have different pre- and post-harvest qualities. Here we present the transcriptome profile datasets of leaves and mature fruits of three sweet cherry cultivars ('Bing', 'Lapin' and 'Rainier'). Using 454 GS-FLX technology (454 Life Sciences, Roche), transcriptomes of leaves and mature fruits were obtained from these cultivars. These transcriptome data sets are reported here.
April 2019: Data in Brief
#14
Matthew Merves, Kimberly Parsons, Adina Alazraki, Jonathan Meisel, Cary Sauer, Hong Li
Hereditary hemorrhagic telangiectasia (HHT) is an underreported autosomal dominant vascular dysplasia. Neonatal presentations of HHT are rare, as this disorder typically presents in adolescence or beyond with epistaxis. We report a female neonate with hematochezia on the 1st day of life secondary to multiple gastrointestinal arteriovenous malformations (AVMs) along with intracranial hemorrhage. We describe her clinical course and management, as well as her novel family mutation in ENG . This is the first reported HHT case with significant gastrointestinal bleeding in the newborn...
January 2019: American Journal of Perinatology Reports
#15
JOURNAL ARTICLE
Jonathan Purtle, Elizabeth A Dodson, Katherine Nelson, Zachary F Meisel, Ross C Brownson
OBJECTIVES: This study sought to characterize primary sources of behavioral health research and dissemination preferences of state legislators and assess differences by political party. METHODS: A 2017 cross-sectional survey of state legislators (N=475) assessed where legislators seek, and the most important features of, behavioral health research. Bivariate analyses and multivariate logistic regression were conducted. RESULTS: Advocacy organizations (53%), legislative staff (51%), and state agencies (48%) were identified most frequently as sources of behavioral health research...
October 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
#16
JOURNAL ARTICLE
Jacquelyn S Meisel, Georgia Sfyroera, Casey Bartow-McKenney, Ciara Gimblet, Julia Bugayev, Joseph Horwinski, Brian Kim, Jonathan R Brestoff, Amanda S Tyldsley, Qi Zheng, Brendan P Hodkinson, David Artis, Elizabeth A Grice
BACKGROUND: The skin harbors complex communities of resident microorganisms, yet little is known of their physiological roles and the molecular mechanisms that mediate cutaneous host-microbe interactions. Here, we profiled skin transcriptomes of mice reared in the presence and absence of microbiota to elucidate the range of pathways and functions modulated in the skin by the microbiota. RESULTS: A total of 2820 genes were differentially regulated in response to microbial colonization and were enriched in gene ontology (GO) terms related to the host-immune response and epidermal differentiation...
January 30, 2018: Microbiome
#17
JOURNAL ARTICLE
Jason T Schaffer, Erik P Hess, Judd E Hollander, Jeffrey A Kline, Carlos A Torres, Deborah B Diercks, Russell Jones, Kelly P Owen, Zachary F Meisel, Michel Demers, Annie Leblanc, Jonathan Inselman, Jeph Herrin, Victor M Montori, Nilay D Shah
BACKGROUND: Patients at low risk for acute coronary syndrome are frequently admitted for observation and cardiac testing, resulting in substantial burden and cost to the patient and the health care system. OBJECTIVES: The purpose of this investigation was to measure the effect of the Chest Pain Choice (CPC) decision aid on overall health care utilization as well as utilization of specific services both during the index emergency department (ED) visit and in the subsequent 45 days...
March 2018: Academic Emergency Medicine
#18
JOURNAL ARTICLE
Kristin L Rising, Judd E Hollander, Jason T Schaffer, Jeffrey A Kline, Carlos A Torres, Deborah B Diercks, Russell Jones, Kelly P Owen, Zachary F Meisel, Michel Demers, Annie Leblanc, Nilay D Shah, Jonathan Inselman, Jeph Herrin, Victor M Montori, Erik P Hess
BACKGROUND: We test the hypotheses that use of the Chest Pain Choice (CPC) decision aid (DA) would be similarly effective in potentially vulnerable subgroups but increase knowledge more in patients with higher education and trust in physicians more in patients from racial minority groups. METHODS: This was a secondary analysis of a multicenter randomized trial in adults with chest pain potentially due to acute coronary syndrome. The trial compared an intervention group engaged in shared decision making (SDM) using CPC to a control group receiving usual care (UC)...
January 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
#19
JOURNAL ARTICLE
Heather L Short, Helene B Fevrier, Jonathan A Meisel, Matthew T Santore, Kurt F Heiss, Mark L Wulkan, Mehul V Raval
INTRODUCTION: Prolonged operative time (OT) is considered a reflection of procedural complexity and may be associated with poor outcomes. Our purpose was to explore the association between prolonged OT and complications in children's surgery. METHODS: 182,857 cases from the 2012-2014 NSQIP-Pediatric were organized into 33 groups. OT for each group was analyzed by quartile, and regression models were used to determine the relationship between prolonged OT and complications...
October 2017: Journal of Pediatric Surgery
#20
RANDOMIZED CONTROLLED TRIAL
Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial.
Erik P Hess, Judd E Hollander, Jason T Schaffer, Jeffrey A Kline, Carlos A Torres, Deborah B Diercks, Russell Jones, Kelly P Owen, Zachary F Meisel, Michel Demers, Annie Leblanc, Nilay D Shah, Jonathan Inselman, Jeph Herrin, Ana Castaneda-Guarderas, Victor M Montori
OBJECTIVE: To compare the effectiveness of shared decision making with usual care in choice of admission for observation and further cardiac testing or for referral for outpatient evaluation in patients with possible acute coronary syndrome. DESIGN: Multicenter pragmatic parallel randomized controlled trial. SETTING: Six emergency departments in the United States. PARTICIPANTS: 898 adults (aged >17 years) with a primary complaint of chest pain who were being considered for admission to an observation unit for cardiac testing (451 were allocated to the decision aid and 447 to usual care), and 361 emergency clinicians (emergency physicians, nurse practitioners, and physician assistants) caring for patients with chest pain...
December 5, 2016: BMJ: British Medical Journal
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