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Megan Durham

Rossitza Lazova, Erin H Seeley, Heinz Kutzner, Richard A Scolyer, Glynis Scott, Lorenzo Cerroni, Isabella Fried, Milena E Kozovska, Arlene S Rosenberg, Victor G Prieto, Bahig M Shehata, Megan M Durham, Gina Henry, Jose L Rodriguez-Peralto, Erica Riveiro-Falkenbach, Jochen T Schaefer, Richard Danialan, Sylvie Fraitag, Sonja Vollenweider-Roten, Alireza Sepehr, Martin Sangueza, Nouf Hijazi, Yamile Corredoira, Rachel Kowal, Olga M Harris, Francisco Bravo, Alan S Boyd, Ralitza Gueorguieva, Richard M Caprioli
BACKGROUND: Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. OBJECTIVE: We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. METHODS: We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS...
August 5, 2016: Journal of the American Academy of Dermatology
Julia K Shinnick, Elizabeth Wang, Cheryl Hulbert, Courtney McCracken, Gail Yvonne Sarson, Anthony Piazza, Heidi Karpen, Megan M Durham
OBJECTIVE: The objective of this study was to assess whether a diet of ≥50% breast milk (BM) was associated with earlier transition off parenteral nutrition (PN) in neonates with gastrointestinal (GI) disorders. METHODS: This retrospective study assessed enteral feeding outcomes of neonates with surgical GI disorders admitted within the first week of life to a single center between January 1, 2012 and August 10, 2015. Outcomes were assessed according to diet from the point of first enteral intake through 7 days of full enteral feeds...
June 22, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
Caitlin A Cundiff, Nancy Elawabdeh, Mina M Naguib, Samuel N Jactel, Dina El Demellawy, Carlos R Abramowsky, Megan M Durham, Lara Youssef, Michael L Wittkamp, Bahig M Shehata
Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a potentially fatal neurologic syndrome in which patients present with a spectrum of central nervous system deficits. Sixty percent of the cases can be attributed to the presence of tumors, most often ovarian teratomas. This report examines 6 pediatric patients who presented with neurologic deficits associated with the presence of such tumors. These cases illustrate a perplexing phenomenon, where benign teratomas could have a possible association with anti-NMDAR encephalitis...
March 2015: Pediatric and Developmental Pathology
Adriana C Vidal, Christina D Williams, Emma H Allott, Lauren E Howard, Delores J Grant, Megan McPhail, Katharine N Sourbeer, Lin Pao Hwa, Paolo Boffetta, Cathrine Hoyo, Stephen J Freedland
BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire...
March 1, 2015: Prostate
Sarah J Hill, Kurt F Heiss, Rohit Mittal, Martha L Clabby, Megan M Durham, Richard Ricketts, Mark L Wulkan
PURPOSE: Controversy remains regarding the management of the asymptomatic heterotaxy syndrome (HS) patient with suspected intestinal rotational abnormalities. We evaluated the outcomes for our HS population to identify frequency of malrotation and identify characteristics of children who might benefit from expectant management. METHODS: After IRB approval, a retrospective review of all patients treated for HS at a large tertiary care children's hospital between January 2008 and June 2012 was performed...
June 2014: Journal of Pediatric Surgery
Alexis R Gaines, Elizabeth L Turner, Patricia G Moorman, Stephen J Freedland, Christopher J Keto, Megan E McPhail, Delores J Grant, Adriana C Vidal, Cathrine Hoyo
PURPOSE: Population-based studies have established a link between race and prostate cancer (PC) risk, but whether race predicts PC after adjusting for clinical characteristics is unclear. We investigated the association between race and risk of low- and high-grade PC in men undergoing initial prostate biopsy in an equal access medical center. METHODS: We conducted a retrospective record review of 887 men (48.6 % black, 51.4 % white) from the Durham Veterans Affairs Medical Center who underwent initial prostate biopsy between 2001 and 2009...
August 2014: Cancer Causes & Control: CCC
Heather A King, Amy S Jeffreys, Megan A McVay, Cynthia J Coffman, Corrine I Voils
This study evaluated spouse health behavior outcomes from a randomized controlled trial of a spouse-assisted lifestyle intervention to reduce patient low-density lipoprotein cholesterol and improve patient health behaviors. Participants were 251 spouses of patients from the Durham Veterans Affairs Medical Center randomized to intervention or usual care. The intervention comprised 9 monthly telephone calls to patients and spouses. Outcomes were assessed at baseline, 6 and 11 months. At 11 months, there were no differences in spouse outcomes between intervention and usual care groups for moderate intensity physical activity (i...
December 2014: Journal of Behavioral Medicine
Beverly H Brummett, Michael A Babyak, Rong Jiang, Svati H Shah, Richard C Becker, Carol Haynes, Megan Chryst-Ladd, Damian M Craig, Elizabeth R Hauser, Ilene C Siegler, Cynthia M Kuhn, Abanish Singh, Redford B Williams
Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (rs6318) of the 5HTR2C gene located on the X-chromosome is associated with hypothalamic-pituitary-adrenal axis response to a stress recall task, and with endophenotypes associated with cardiovascular disease (CVD). These findings suggest that individuals carrying the rs6318 Ser23 C allele will be at higher risk for CVD compared to Cys23 G allele carriers. The present study examined allelic variation in rs6318 as a predictor of coronary artery disease (CAD) severity and a composite endpoint of all-cause mortality or myocardial infarction (MI) among Caucasian participants consecutively recruited through the cardiac catheterization laboratory at Duke University Hospital (Durham, NC) as part of the CATHGEN biorepository...
2013: PloS One
Samuel Noah Jactel, Carlos R Abramowsky, Matthew Schniederjan, Megan M Durham, Richard R Ricketts, Matthew S Clifton, Karl M Langberg, Nancy Elawabdeh, Samir Pandya, Sarah Talebagha, Bahig M Shehata
Noniatrogenic neonatal gastric perforation is a rare and life-threatening condition whose etiology is often unclear. Interstitial cells of Cajal act as gastrointestinal pacemaker cells and express the proto-oncogene c-Kit. Six new cases were identified at our institution which presented with no mechanical, pharmacologic, or otherwise medical-related intervention prior to rupture. The number of interstitial cells of Cajal in nonnecrotic muscularis propria from five random high-power fields per specimen was compared using immunohistochemical stains for c-Kit...
December 2013: Fetal and Pediatric Pathology
Adil A Shah, Michael Karass, Andrew J Page, Bahig M Shehata, Megan M Durham
Von Meyenburg complexes (VMCs), also known as bile duct hamartomas, are a part of a group of ductal plate malformations. They are typically present intrahepatically. In this case, we present to our knowledge the first report of an extra-hepatic VMC in the pediatric population. The patient presented as a 10-month-old infant with a weeklong history of progressive breathing difficulty. A chest radiograph was obtained, showing intestinal loops in the thoracic cavity consistent with a Morgagni's hernia, unrelated to his breathing difficulty...
July 2013: Pediatric Surgery International
Leticia A Shanley, Megan R Durham
No abstract text is available yet for this article.
May 2013: Clinical Pediatrics
Miriam C Morey, Carl F Pieper, David E Edelman, William S Yancy, Jennifer B Green, Helen Lum, Matthew J Peterson, Richard Sloane, Patricia A Cowper, Hayden B Bosworth, Kim M Huffman, James T Cavanaugh, Katherine S Hall, Megan P Pearson, Gregory A Taylor
OBJECTIVES: To determine whether a home-based multicomponent physical activity counseling (PAC) intervention is effective in reducing glycemic measures in older outpatients with prediabetes mellitus. DESIGN: Controlled clinical trial. SETTING: Primary care clinics of the Durham Veterans Affairs (VA) Medical Center between September 29, 2008, and March 25, 2010. PARTICIPANTS: Three hundred two overweight (body mass index 25-45 kg/m(2) ), older (60-89) outpatients with impaired glucose tolerance (fasting blood glucose 100-125 mg/dL, glycosylated hemoglobin (HbA1c) <7%) randomly assigned to a PAC intervention group (n = 180) or a usual care control group (n = 122)...
September 2012: Journal of the American Geriatrics Society
Adriana C Vidal, Delores J Grant, Christina D Williams, Elizabeth Masko, Emma H Allott, Kathryn Shuler, Megan McPhail, Alexis Gaines, Elizabeth Calloway, Leah Gerber, Jen-Tsan Chi, Stephen J Freedland, Cathrine Hoyo
Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004-2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer...
2012: Journal of Cancer Epidemiology
Dominic O Ansari, Ira R Horowitz, Howard M Katzenstein, Megan M Durham, Natia Esiashvili
Pediatric cervicovaginal clear cell adenocarcinoma (CCA) is rare but continues to occur in the postdiethylstilbestrol era. Ideal management is unclear. We report a case of locally advanced, node-negative CCA in a 14-year-old girl without a history of diethylstilbestrol exposure. The patient's disease was FIGO stage IIIA, involving the cervix, vagina, and parametrium. She was treated with concurrent cisplatin and external beam radiation, followed by interstitial low-dose rate brachytherapy. The patient has no evidence of disease after 2 years of follow-up...
July 2012: Journal of Pediatric Hematology/oncology
Jenny Lin, Megan M Durham, Richard Ricketts, Carlos R Abramowsky, Charlotte Katherine Steelman, Bahig M Shehata
Hepatic pulmonary fusion (HPF) is characterized by a fibrous connection between the liver and lung tissue. We present two cases of hepatic pulmonary fusion diagnosed with right diaphragmatic hernia and a third case with Pentalogy of Cantrell exhibiting complete agenesis of the diaphragm and finger-like projections of liver adhered to the right lung. It has been proposed that this anomaly is secondary to developmental failure of the mesoderm between days 14-18 after conception and is attributed to diaphragmatic maldevelopment...
December 2012: Fetal and Pediatric Pathology
Sarah J Hill, Megan M Durham
Whereas inguinal hernias are commonly encountered in the neonatal population, giant hernias containing the entire small bowel and with complete inguinal floor disruption are significantly less common. These cases present clinical and technical challenges with the obliteration of normal anatomy and an attenuation of the expected abdominal domain. There is a scant literature available describing these hernias or their management in neonates. In this case report, we describe a neonate who presented with a giant unilateral inguinal scrotal hernia complicated by in utero perforation...
November 2011: Journal of Pediatric Surgery
Sarah J Hill, Megan M Durham
BACKGROUND: Cryptorchidism is commonly associated with gastroschisis. Management of the undescended testes varies with regard to technique and timing of orchidopexy. To evaluate the appropriate timing of and procedure for orchidopexy in patients with gastroschisis, we reviewed our experience. METHODS: Male neonates admitted between January 1999 and September 2010 with gastroschisis were reviewed. This retrospective study was conducted after institutional review board approval...
September 2011: Journal of Pediatric Surgery
Ayako W Fujita, Charlotte K Steelman, Carlos R Abramowsky, Richard R Ricketts, Megan Durham, Matthew Clifton, Samir Pandya, Bahig M Shehata
Ciliated hepatic foregut cysts (CHFCs) are rare congenital legions that arise from the embryonic foregut. The cysts are formed during fetal development by evagination from their respective portions of the foregut, and are characterized by a ciliated epithelial lining. Approximately 100 cases of CHFC have been reported, of which only 13 were in children. Although CHFC is typically benign, malignant transformation to squamous cell carcinoma (SCC) has been reported in 3 cases. Survival rate after progression to malignancy is poor, as SCC in this setting is biologically aggressive...
September 2011: Pediatric and Developmental Pathology
Conrad Cole, Cole Conrad, Alessandrina Freitas, Matthew S Clifton, Megan M Durham
Intestinal atresias are a common cause of newborn bowel obstruction (Dalla Vecchia LK, Grosfeld JL, West KW, et al, Intestinal atresia and stenosis: a 25-year experience with 277 cases. Arch Surg 1998; 133[5]:490-496). Hereditary multiple intestinal atresias, first reported by Guttman et al in 1973, is the rarest form of multiple atresias (Guttman FM, Braun P, Garance PH, et al, Multiple atresias and a new syndrome of hereditary multiple atresias involving the gastrointestinal tract from stomach to rectum. J Pediatr Surg 1973;8:633-640; Bass J, Pyloric atresia associated with multiple intestinal atresias and immune deficiency...
April 2010: Journal of Pediatric Surgery
Bahair Ghazi, Grant W Carlson, Douglas R Murray, Kenneth W Gow, Andrew Page, Megan Durham, David A Kooby, Douglas Parker, Louis Rapkin, David H Lawson, Keith A Delman
BACKGROUND: Atypical spitzoid melanocytic neoplasms (ASMN) are cutaneous lesions of uncertain malignant potential, which can be difficult to distinguish from cutaneous melanoma. Sentinel lymph node (SLN) biopsy is a safe and useful prognostic tool for staging melanoma, but its role in staging ASMNs is not established nor is the significance of positive SLNs in these patients known. This study attempts to characterize the significance of nodal disease in ASMN. METHODS: Patients with ASMNs who presented to the melanoma service from 1992 to 2007 were identified from a prospective database...
September 2010: Annals of Surgical Oncology
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