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Amina Bhatia

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https://www.readbyqxmd.com/read/27717564/prospective-validation-of-the-shock-index-pediatric-adjusted-sipa-in-blunt-liver-and-spleen-trauma-an-atomac-study
#1
Maria E Linnaus, David M Notrica, Crystal S Langlais, Shawn D St Peter, Charles M Leys, Daniel J Ostlie, R Todd Maxson, Todd Ponsky, David W Tuggle, James W Eubanks, Amina Bhatia, Adam C Alder, Cynthia Greenwell, Nilda M Garcia, Karla A Lawson, Prasenjeet Motghare, Robert W Letton
BACKGROUND: Age-adjusted pediatric shock index (SIPA) does not require knowledge of age-adjusted blood pressure norms, yet correlates with mortality, serious injury, and need for transfusion in trauma. No prospective studies support its validity. METHODS: A multicenter prospective observational study of patients 4-16years presenting April 2013-January 2016 with blunt liver and/or spleen injury (BLSI). SIPA (maximum heart rate/minimum systolic blood pressure) thresholds of >1...
September 23, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27707653/the-impact-of-morbid-obesity-on-solid-organ-injury-in-children-using-the-atomac-protocol-at-a-pediatric-level-i-trauma-center
#2
Nathan Vaughan, Jeff Tweed, Cynthia Greenwell, David M Notrica, Crystal S Langlais, Shawn D St Peter, Charles M Leys, Daniel J Ostlie, R Todd Maxson, Todd Ponsky, David W Tuggle, James W Eubanks, Amina Bhatia, Cynthia Greenwell, Nilda M Garcia, Karla A Lawson, Prasenjeet Motghare, Robert W Letton, Adam C Alder
INTRODUCTION: Obesity is an epidemic in the pediatric population. Childhood obesity in trauma has been associated with increased incidence of long-bone fractures, longer ICU stays, and decreased closed head injuries. We investigated for differences in the likelihood of failure of non-operative management (NOM), and injury grade using a subset of a multi-institutional, prospective database of pediatric patients with solid organ injury (SOI). METHODS: We prospectively collected data on all pediatric patients (<18years) admitted for liver or splenic injury from September 2013 to January 2016...
September 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25092080/the-association-of-type-of-surgical-closure-on-length-of-stay-among-infants-with-gastroschisis-born%C3%A2-34-weeks-gestation
#3
MULTICENTER STUDY
Karna Murthy, Jacquelyn R Evans, Amina M Bhatia, David H Rothstein, Rajan Wadhawan, Isabella Zaniletti, Rakesh Rao, Cary Thurm, Amit M Mathur, Anthony J Piazza, James E Stein, Kristina M Reber, Billie Lou Short, Michael A Padula, David J Durand, Jeanette M Asselin, Eugenia K Pallotto, Francine D Dykes
BACKGROUND/PURPOSE: The optimal surgical approach in infants with gastroschisis (GS) is unknown. The purpose of this study was to estimate the association between staged closure and length of stay (LOS) in infants with GS. DESIGN/METHODS: We used the Children's Hospital Neonatal Database to identify surviving infants with GS born ≥34 weeks' gestation referred to participating NICUs. Infants with complex GS, bowel atresia, or referred after 2 days of age were excluded...
August 2014: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/23966125/cytokine-levels-in-the-preterm-infant-with-neonatal-intestinal-injury
#4
Amina M Bhatia, Barbara J Stoll, Mary J Cismowski, Shannon E Hamrick
OBJECTIVES: The purpose of this study is to characterize the cytokine response of preterm newborns with surgical necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) before surgical treatment and to relate these finding to intestinal disease (NEC vs. SIP). STUDY DESIGN: The study was a 14-month prospective, cohort study of neonates undergoing surgery or drainage for NEC or SIP or surgical ligation of patent ductus arteriosus (PDA). Multiplex cytokine detection technology was used to analyze six inflammatory markers: interleukin-2, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 β (IL-1β), interferon-gamma, and tumor necrosis factor-α (TNF-α)...
June 2014: American Journal of Perinatology
https://www.readbyqxmd.com/read/23816009/hirschsprung-s-disease-in-the-preterm-infant-implications-for-diagnosis-and-outcome
#5
Katherine J Baxter, Amina M Bhatia
Hirschsprung's disease (HD), congenital absence of ganglion cells, is considered uncommon in preterm infants. The aim was to describe the frequency, presentation, and surgical outcomes of preterm infants with HD. A retrospective cohort study was conducted of all patients diagnosed with HD from 2002 to 2012 at a single children's hospital. Clinical presentation and surgical outcomes were obtained for term (37 weeks of gestation or greater) and preterm infants. One hundred twenty-nine subjects with HD were identified, 24 (19%) preterm and 105 (81%) term...
July 2013: American Surgeon
https://www.readbyqxmd.com/read/22008347/right-paraduodenal-hernia-leading-to-bowel-strangulation
#6
Geoffrey Lam, Matthew S Clifton, Amina Mira Bhatia
Up to half of all internal hernias are caused by paraduodenal hernia, a rare congenital midgut malrotation that accounts for less than 1% of all intestinal obstructions. The diagnosis may arise from an incidental finding on abdominal imaging or the patient may present with abdominal pain, vomiting, and obstipation. Early recognition and management of this disease entity are keys because serious complications such as bowel ischemia and infarction may result from a delay in diagnosis. We present a case involving a 14-year-old boy with gangrenous small bowel secondary to right paraduodenal hernia...
October 2011: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/21944527/pencils-and-pens-an-under-recognized-source-of-penetrating-injuries-in-children
#7
COMPARATIVE STUDY
Sarah B Fisher, Matthew S Clifton, Amina M Bhatia
Unlike other sharp objects, pens and pencils are readily available to children both at home and school. Although case reports are published, no series of pen or pencil injuries have been reported in the recent literature. We therefore reviewed the incidence and injury profiles of writing instruments as compared with other sources of penetrating trauma. The trauma registry from a large urban pediatric hospital system was queried for nonmissile, nonbite penetrating injuries from 2005 through 2009. Retrospective data was collected on demographics, injuries, operations, admissions, and mortalities...
August 2011: American Surgeon
https://www.readbyqxmd.com/read/21939355/cardiaplication-a-novel-surgical-technique-for-refractory-gastroesophageal-reflux-in-the-pediatric-population
#8
Sarah J Hill, Samir Pandya, Matthew S Clifton, Amina Bhatia, Mark L Wulkan
INTRODUCTION: We encountered 3 patients with severe gastroesophageal reflux disease and tubular stomachs precluding fundoplication. Here, we report the use of an innovative technique, cardiaplication, as an alternative approach for antireflux surgery. METHODS: Three infants with medically refractory gastroesophageal reflux disease (GERD) were referred for fundoplication. In each case, the patient's anatomy prevented a traditional fundoplication from being performed...
November 2011: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/20046361/is-familiality-associated-with-downward-occupation-drift-in-schizophrenia
#9
Triptish Bhatia, Satabdi Chakraborty, Pramod Thomas, Amina Naik, Sati Mazumdar, Vishwajit L Nimgaonkar, Smita N Deshpande
OBJECTIVE: Downward occupational drift has been extensively investigated in schizophrenia. It is known that certain illness related factors, such as severity, affect drift, but the impact of familial factors has not been investigated. METHODS: Occupation drift was studied among patients with schizophrenia/schizoaffective disorder (SZ/SZA)(n=523) and 130 affected sib pairs (ASPs). Drift was analyzed in relation to familiality as well as demographic and clinical variables...
September 2008: Psychiatry Investigation
https://www.readbyqxmd.com/read/19606909/pseudoangiomatous-stromal-hyperplasia-of-the-breast-in-pediatric-patients-an-underrecognized-entity
#10
Bahig M Shehata, Inessa Fishman, Margaret H Collings, Jenny Wang, Janet M Poulik, Richard R Ricketts, Paul M Parker, Kurt Heiss, Amina M Bhatia, Heath D Worcester, Kenneth W Gow
Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion consisting of mammary stromal proliferation with anastomosing slits mimicking vascular spaces. Grossly, it most often resembles fibroadenoma, but may commonly be confused with angiosarcoma and other types of benign vascular proliferations. While PASH has been described in female and male adults since the mid-1980s, there have been only a few accounts in the pediatric population. We present a series of 12 pediatric patients with PASH, including a 3-year-old male, who we believe to be the youngest patient to present with this entity...
November 2009: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/16875088/left-sided-gastroschisis
#11
REVIEW
Kenneth W Gow, Amina Bhatia, Daniel F Saad, Mark L Wulkan, Kurt F Heiss
Gastroschisis is a periumbilical, abdominal wall defect arising to the right of the umbilicus. We describe the clinical course of a left-sided gastroschisis in a term female born at 39 weeks' gestation. To our knowledge, there have been only 14 left-sided abdominal wall defects reported in the literature. We discuss our case and review the literature to try to determine if there is any clinic difference between right- versus left-sided lesions to make recommendations as to management.
July 2006: American Surgeon
https://www.readbyqxmd.com/read/15943400/video-assisted-thoracoscopic-division-of-vascular-rings-in-pediatric-patients
#12
COMPARATIVE STUDY
Curt S Koontz, Amina Bhatia, Joe Forbess, Mark L Wulkan
Vascular rings are usually repaired via left thoracotomy. We report our series of pediatric patients with vascular rings that were repaired thoracoscopically. From February 2002 to September 2004, 13 patients underwent video-assisted thoracoscopic surgical techniques (VATS) division of their vascular ring. Chest magnetic resonance arterography (MRA) and/or computed tomographic arteriography (CTA) were used to evaluate the vascular ring in most patients. Patients were chosen for VATS repair based on surgeon's choice and type of vascular ring...
April 2005: American Surgeon
https://www.readbyqxmd.com/read/15137018/is-the-use-of-laparoscopy-to-determine-presence-of-contralateral-patent-processus-vaginalis-justified-in-children-greater-than-2-years-of-age
#13
Amina M Bhatia, Kenneth W Gow, Kurt F Heiss, Ginger Barr, Mark L Wulkan
PURPOSE: Contralateral inguinal hernia exploration in cases of unilateral inguinal hernia remains a controversial topic. The authors have been using the in-line laparoscopic technique of contralateral evaluation for unilateral inguinal hernia in children less than 2 years of age. Because of the case of the procedure and lack of morbidity, we decided to expand the use of this procedure up to age 8 years in January 2000. The purpose of this study is to evaluate if the incidence of contralateral hernia in children greater than 2 years justifies the procedure...
May 2004: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/15081371/multifaceted-pancreatic-mesenchymal-control-of-epithelial-lineage-selection
#14
Zhixing Li, Pradip Manna, Hiroyuki Kobayashi, Troy Spilde, Amina Bhatia, Barry Preuett, Krishna Prasadan, Mark Hembree, George K Gittes
Mouse pancreatic development is critically dependent on epithelial-mesenchymal interactions. The pancreas differs from other epithelial-mesenchymal organs in that the epithelium gives rise to both epithelial exocrine cells and non-epithelial endocrine cells. We studied the nature of the interactions between the epithelium and mesenchyme with respect to the decision between exocrine and endocrine lineages. We show here a tripartite influence of mesenchyme on the developing epithelium. First, close proximity or contact of mesenchyme with the epithelium induces exocrine differentiation...
May 1, 2004: Developmental Biology
https://www.readbyqxmd.com/read/15065023/aberrant-fibroblast-growth-factor-receptor-2-signalling-in-esophageal-atresia-with-tracheoesophageal-fistula
#15
Troy L Spilde, Amina M Bhatia, Sheilendra S Mehta, Mark J Hembree, Barry L Preuett, Daniel J Ostlie, Krishna Prasadan, Zhixing Li, Charles L Snyder, George K Gittes
BACKGROUND: Although the pathogenesis of esophageal atresia with tracheoesophageal fistula (EA/TEF) remains unknown, it has been shown that despite its esophageal appearance, the fistula tract originates from respiratory epithelium. The authors now hypothesize that defects in fibroblast growth factor (FGF) signaling contribute to the esophaguslike phenotype of the fistula tract. FGF2R is critical to normal lung morphogenesis and occurs in 2 isoforms (FGF2RIIIb and FGF2RIIIc), each with different ligand-binding specificity...
April 2004: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/12947339/defective-sonic-hedgehog-signaling-in-esophageal-atresia-with-tracheoesophageal-fistula
#16
Troy L Spilde, Amina M Bhatia, Sheilendra Mehta, Daniel J Ostlie, Mark J Hembree, Barry L Preuett, Krishna Prasadan, Zhixing Li, Charles L Snyder, George K Gittes
BACKGROUND: The pathogenesis of esophageal atresia and tracheoesophageal fistula (EA/TEF) remains unknown. We have found previously that an initial esophageal atresia, followed by an abnormal (absent) branching pattern of the middle branch of a trifurcation of the lung/tracheal bud, leads to the neonatal finding of TEF. Mice null mutant for hedgehog signaling can experience the development of EA/TEF, but the mechanism for this development is also unknown. Given that EA/TEF in humans appears not to be due to genetic defects, a hedgehog mutation cause seems very unlikely...
August 2003: Surgery
https://www.readbyqxmd.com/read/12632370/fibroblast-growth-factor-signaling-in-the-developing-tracheoesophageal-fistula
#17
Troy L Spilde, Amina M Bhatia, Julie K Marosky, Barry Preuett, Hiroyuki Kobayashi, Mark J Hembree, Krishna Prasadan, Erica Daume, Charles L Snyder, George K Gittes
BACKGROUND/PURPOSE: The Adriamycin-induced rat model of esophageal atresia and tracheoesophageal fistula (EA/TEF) provides a reliable system for the study of EA/TEF pathogenesis. The authors previously hypothesized that faulty branching lung morphogenesis pathways were a critical component of its pathogenesis. The authors have found evidence for faulty fibroblast growth factor (FGF) signaling related to epithelial-mesenchymal interactions in the fistula tract. To better define FGF signaling, the differential expression of FGF ligands and their receptors between lung, fistula tract, and esophagus are described...
March 2003: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/12632368/a-role-for-sonic-hedgehog-signaling-in-the-pathogenesis-of-human-tracheoesophageal-fistula
#18
Troy Spilde, Amina Bhatia, Daniel Ostlie, Julie Marosky, George Holcomb, Charles Snyder, George Gittes
BACKGROUND/PURPOSE: Many theories of the pathogenesis of esophageal atresia with tracheoesophageal fistula (EA/TEF) have been proposed, but no specific mechanism has been demonstrated. The authors previously reported data suggesting a respiratory origin of the fistula tract in the rat model and in humans. Sonic hedgehog (Shh) "knockout" mice have the VACTERL association, and thus it was hypothesized that defects in Shh signaling may exist in the human neonatal EA/TEF fistula tract. METHODS: With IRB approval, human proximal esophageal pouch and distal fistula samples were removed at the time of standard repair of EA/TEF in accordance with what the surgeons deemed appropriate in preparation for anastomosis...
March 2003: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/12401714/glucagon-is-required-for-early-insulin-positive-differentiation-in-the-developing-mouse-pancreas
#19
Krishna Prasadan, Erica Daume, Barry Preuett, Troy Spilde, Amina Bhatia, Hiroyuki Kobayashi, Mark Hembree, Pradip Manna, George K Gittes
The embryonic pancreas is thought to develop from pluripotent endodermal cells that give rise to endocrine and exocrine cells. A key guidance mechanism for pancreatic development has previously been found to be epithelial-mesenchymal interaction. Interactions within the epithelium, however, have not been well studied. Glucagon is the earliest peptide hormone present at appreciable levels in the developing pancreatic epithelium (embryonic day [E]-9.5 in mouse). Insulin accumulation begins slightly later (E11 in mouse), followed by a rapid accumulation during the "second wave" of insulin differentiation ( approximately E15)...
November 2002: Diabetes
https://www.readbyqxmd.com/read/12360493/retinoid-signaling-controls-mouse-pancreatic-exocrine-lineage-selection-through-epithelial-mesenchymal-interactions
#20
Hiroyuki Kobayashi, Troy L Spilde, Amina M Bhatia, R Brendhan Buckingham, Mark J Hembree, Krishna Prasadan, Barry L Preuett, Masayuki Imamura, George K Gittes
BACKGROUND & AIMS: The early embryonic pancreas gives rise to exocrine (ducts and acini) and endocrine lineages. Control of exocrine differentiation is poorly understood, but may be a critical avenue through which to manipulate pancreatic ductal carcinoma. Retinoids have been shown to change the character of pancreatic ductal cancer cells to a less malignant phenotype. We have shown that 9-cis retinoic acid (9cRA) inhibits acinar differentiation in the developing pancreas, in favor of ducts, and we wanted to determine the role of retinoids in duct versus acinar differentiation...
October 2002: Gastroenterology
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