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Amina Bhatia

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https://www.readbyqxmd.com/read/28665242/changes-in-use-of-cervical-spine-magnetic-resonance-imaging-for-pediatric-patients-with-nonaccidental-trauma
#1
Ahyuda Oh, Michael Sawvel, David Heaner, Amina Bhatia, Andrew Reisner, R Shane Tubbs, Joshua J Chern
OBJECTIVE Past studies have suggested correlations between abusive head trauma and concurrent cervical spine (c-spine) injury. Accordingly, c-spine MRI (cMRI) has been increasingly used in radiographic assessments. This study aimed to determine trends in cMRI use and treatment, and outcomes related to c-spine injury in children with nonaccidental trauma (NAT). METHODS A total of 503 patients with NAT who were treated between 2009 and 2014 at a single pediatric health care system were identified from a prospectively maintained database...
September 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28363471/hypotension-and-the-need-for-transfusion-in-pediatric-blunt-spleen-and-liver-injury-an-atomac-prospective-study
#2
Summer R Magoteaux, David M Notrica, Crystal S Langlais, Maria E Linnaus, Alexander R Raines, Robert W Letton, Adam C Alder, Cynthia Greenwell, James W Eubanks, Karla A Lawson, Nilda M Garcia, Shawn D St Peter, Daniel J Ostlie, Charles M Leys, Amina Bhatia, R Todd Maxson, David W Tuggle, Todd A Ponsky
PURPOSE: Children with blunt liver or spleen injury (BLSI) requiring early transfusion may present without hypotension despite significant hypovolemia. This study sought to determine the relationship between early transfusion in pediatric BLSI and hypotension. METHODS: Secondary analysis of a 10-institution prospective observational study was performed of patients 18years and younger presenting with BLSI. Patients with central nervous system (CNS) injury were excluded...
June 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28099382/failure-of-nonoperative-management-of-pediatric-blunt-liver-and-spleen-injuries-a-prospective-arizona-texas-oklahoma-memphis-arkansas-consortium-study
#3
Maria E Linnaus, Crystal S Langlais, Nilda M Garcia, Adam C Alder, James W Eubanks, R Todd Maxson, Robert W Letton, Todd A Ponsky, Shawn D St Peter, Charles Leys, Amina Bhatia, Daniel J Ostlie, David W Tuggle, Karla A Lawson, Alexander R Raines, David M Notrica
BACKGROUND: Nonoperative management (NOM) is standard of care for most pediatric blunt liver and spleen injuries (BLSI); only 5% of patients fail NOM in retrospective reports. No prospective studies examine failure of NOM of BLSI in children. The aim of this study was to determine the frequency and clinical characteristics of failure of NOM in pediatric BLSI patients. METHODS: A prospective observational study was conducted on patients 18 years or younger presenting to any of 10 Level I pediatric trauma centers April 2013 and January 2016 with BLSI on computed tomography...
April 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27940091/pathogenesis-of-nec-role-of-the-innate-and-adaptive-immune-response
#4
REVIEW
Timothy W Denning, Amina M Bhatia, Andrea F Kane, Ravi M Patel, Patricia W Denning
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants with high case fatality and significant morbidity among survivors. Immaturity of intestinal host defenses predisposes the premature infant gut to injury. An abnormal bacterial colonization pattern with a deficiency of commensal bacteria may lead to a further breakdown of these host defense mechanisms, predisposing the infant to NEC. Here, we review the role of the innate and adaptive immune system in the pathophysiology of NEC.
February 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/27717564/prospective-validation-of-the-shock-index-pediatric-adjusted-sipa-in-blunt-liver-and-spleen-trauma-an-atomac-study
#5
MULTICENTER STUDY
Maria E Linnaus, David M Notrica, Crystal S Langlais, Shawn D St Peter, Charles M Leys, Daniel J Ostlie, R Todd Maxson, Todd Ponsky, David W Tuggle, James W Eubanks, Amina Bhatia, Adam C Alder, Cynthia Greenwell, Nilda M Garcia, Karla A Lawson, Prasenjeet Motghare, Robert W Letton
BACKGROUND: Age-adjusted pediatric shock index (SIPA) does not require knowledge of age-adjusted blood pressure norms, yet correlates with mortality, serious injury, and need for transfusion in trauma. No prospective studies support its validity. METHODS: A multicenter prospective observational study of patients 4-16years presenting April 2013-January 2016 with blunt liver and/or spleen injury (BLSI). SIPA (maximum heart rate/minimum systolic blood pressure) thresholds of >1...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27707653/the-impact-of-morbid-obesity-on-solid-organ-injury-in-children-using-the-atomac-protocol-at-a-pediatric-level-i-trauma-center
#6
Nathan Vaughan, Jeff Tweed, Cynthia Greenwell, David M Notrica, Crystal S Langlais, Shawn D St Peter, Charles M Leys, Daniel J Ostlie, R Todd Maxson, Todd Ponsky, David W Tuggle, James W Eubanks, Amina Bhatia, Cynthia Greenwell, Nilda M Garcia, Karla A Lawson, Prasenjeet Motghare, Robert W Letton, Adam C Alder
INTRODUCTION: Obesity is an epidemic in the pediatric population. Childhood obesity in trauma has been associated with increased incidence of long-bone fractures, longer ICU stays, and decreased closed head injuries. We investigated for differences in the likelihood of failure of non-operative management (NOM), and injury grade using a subset of a multi-institutional, prospective database of pediatric patients with solid organ injury (SOI). METHODS: We prospectively collected data on all pediatric patients (<18years) admitted for liver or splenic injury from September 2013 to January 2016...
February 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25092080/the-association-of-type-of-surgical-closure-on-length-of-stay-among-infants-with-gastroschisis-born%C3%A2-34-weeks-gestation
#7
MULTICENTER STUDY
Karna Murthy, Jacquelyn R Evans, Amina M Bhatia, David H Rothstein, Rajan Wadhawan, Isabella Zaniletti, Rakesh Rao, Cary Thurm, Amit M Mathur, Anthony J Piazza, James E Stein, Kristina M Reber, Billie Lou Short, Michael A Padula, David J Durand, Jeanette M Asselin, Eugenia K Pallotto, Francine D Dykes
BACKGROUND/PURPOSE: The optimal surgical approach in infants with gastroschisis (GS) is unknown. The purpose of this study was to estimate the association between staged closure and length of stay (LOS) in infants with GS. DESIGN/METHODS: We used the Children's Hospital Neonatal Database to identify surviving infants with GS born ≥34 weeks' gestation referred to participating NICUs. Infants with complex GS, bowel atresia, or referred after 2 days of age were excluded...
August 2014: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/23966125/cytokine-levels-in-the-preterm-infant-with-neonatal-intestinal-injury
#8
Amina M Bhatia, Barbara J Stoll, Mary J Cismowski, Shannon E Hamrick
OBJECTIVES: The purpose of this study is to characterize the cytokine response of preterm newborns with surgical necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP) before surgical treatment and to relate these finding to intestinal disease (NEC vs. SIP). STUDY DESIGN: The study was a 14-month prospective, cohort study of neonates undergoing surgery or drainage for NEC or SIP or surgical ligation of patent ductus arteriosus (PDA). Multiplex cytokine detection technology was used to analyze six inflammatory markers: interleukin-2, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 β (IL-1β), interferon-gamma, and tumor necrosis factor-α (TNF-α)...
June 2014: American Journal of Perinatology
https://www.readbyqxmd.com/read/23816009/hirschsprung-s-disease-in-the-preterm-infant-implications-for-diagnosis-and-outcome
#9
Katherine J Baxter, Amina M Bhatia
Hirschsprung's disease (HD), congenital absence of ganglion cells, is considered uncommon in preterm infants. The aim was to describe the frequency, presentation, and surgical outcomes of preterm infants with HD. A retrospective cohort study was conducted of all patients diagnosed with HD from 2002 to 2012 at a single children's hospital. Clinical presentation and surgical outcomes were obtained for term (37 weeks of gestation or greater) and preterm infants. One hundred twenty-nine subjects with HD were identified, 24 (19%) preterm and 105 (81%) term...
July 2013: American Surgeon
https://www.readbyqxmd.com/read/22008347/right-paraduodenal-hernia-leading-to-bowel-strangulation
#10
Geoffrey Lam, Matthew S Clifton, Amina Mira Bhatia
Up to half of all internal hernias are caused by paraduodenal hernia, a rare congenital midgut malrotation that accounts for less than 1% of all intestinal obstructions. The diagnosis may arise from an incidental finding on abdominal imaging or the patient may present with abdominal pain, vomiting, and obstipation. Early recognition and management of this disease entity are keys because serious complications such as bowel ischemia and infarction may result from a delay in diagnosis. We present a case involving a 14-year-old boy with gangrenous small bowel secondary to right paraduodenal hernia...
October 2011: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/21944527/pencils-and-pens-an-under-recognized-source-of-penetrating-injuries-in-children
#11
COMPARATIVE STUDY
Sarah B Fisher, Matthew S Clifton, Amina M Bhatia
Unlike other sharp objects, pens and pencils are readily available to children both at home and school. Although case reports are published, no series of pen or pencil injuries have been reported in the recent literature. We therefore reviewed the incidence and injury profiles of writing instruments as compared with other sources of penetrating trauma. The trauma registry from a large urban pediatric hospital system was queried for nonmissile, nonbite penetrating injuries from 2005 through 2009. Retrospective data was collected on demographics, injuries, operations, admissions, and mortalities...
August 2011: American Surgeon
https://www.readbyqxmd.com/read/21939355/cardiaplication-a-novel-surgical-technique-for-refractory-gastroesophageal-reflux-in-the-pediatric-population
#12
Sarah J Hill, Samir Pandya, Matthew S Clifton, Amina Bhatia, Mark L Wulkan
INTRODUCTION: We encountered 3 patients with severe gastroesophageal reflux disease and tubular stomachs precluding fundoplication. Here, we report the use of an innovative technique, cardiaplication, as an alternative approach for antireflux surgery. METHODS: Three infants with medically refractory gastroesophageal reflux disease (GERD) were referred for fundoplication. In each case, the patient's anatomy prevented a traditional fundoplication from being performed...
November 2011: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/20046361/is-familiality-associated-with-downward-occupation-drift-in-schizophrenia
#13
Triptish Bhatia, Satabdi Chakraborty, Pramod Thomas, Amina Naik, Sati Mazumdar, Vishwajit L Nimgaonkar, Smita N Deshpande
OBJECTIVE: Downward occupational drift has been extensively investigated in schizophrenia. It is known that certain illness related factors, such as severity, affect drift, but the impact of familial factors has not been investigated. METHODS: Occupation drift was studied among patients with schizophrenia/schizoaffective disorder (SZ/SZA)(n=523) and 130 affected sib pairs (ASPs). Drift was analyzed in relation to familiality as well as demographic and clinical variables...
September 2008: Psychiatry Investigation
https://www.readbyqxmd.com/read/19606909/pseudoangiomatous-stromal-hyperplasia-of-the-breast-in-pediatric-patients-an-underrecognized-entity
#14
Bahig M Shehata, Inessa Fishman, Margaret H Collings, Jenny Wang, Janet M Poulik, Richard R Ricketts, Paul M Parker, Kurt Heiss, Amina M Bhatia, Heath D Worcester, Kenneth W Gow
Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion consisting of mammary stromal proliferation with anastomosing slits mimicking vascular spaces. Grossly, it most often resembles fibroadenoma, but may commonly be confused with angiosarcoma and other types of benign vascular proliferations. While PASH has been described in female and male adults since the mid-1980s, there have been only a few accounts in the pediatric population. We present a series of 12 pediatric patients with PASH, including a 3-year-old male, who we believe to be the youngest patient to present with this entity...
November 2009: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/16875088/left-sided-gastroschisis
#15
REVIEW
Kenneth W Gow, Amina Bhatia, Daniel F Saad, Mark L Wulkan, Kurt F Heiss
Gastroschisis is a periumbilical, abdominal wall defect arising to the right of the umbilicus. We describe the clinical course of a left-sided gastroschisis in a term female born at 39 weeks' gestation. To our knowledge, there have been only 14 left-sided abdominal wall defects reported in the literature. We discuss our case and review the literature to try to determine if there is any clinic difference between right- versus left-sided lesions to make recommendations as to management.
July 2006: American Surgeon
https://www.readbyqxmd.com/read/15943400/video-assisted-thoracoscopic-division-of-vascular-rings-in-pediatric-patients
#16
COMPARATIVE STUDY
Curt S Koontz, Amina Bhatia, Joe Forbess, Mark L Wulkan
Vascular rings are usually repaired via left thoracotomy. We report our series of pediatric patients with vascular rings that were repaired thoracoscopically. From February 2002 to September 2004, 13 patients underwent video-assisted thoracoscopic surgical techniques (VATS) division of their vascular ring. Chest magnetic resonance arterography (MRA) and/or computed tomographic arteriography (CTA) were used to evaluate the vascular ring in most patients. Patients were chosen for VATS repair based on surgeon's choice and type of vascular ring...
April 2005: American Surgeon
https://www.readbyqxmd.com/read/15137018/is-the-use-of-laparoscopy-to-determine-presence-of-contralateral-patent-processus-vaginalis-justified-in-children-greater-than-2-years-of-age
#17
Amina M Bhatia, Kenneth W Gow, Kurt F Heiss, Ginger Barr, Mark L Wulkan
PURPOSE: Contralateral inguinal hernia exploration in cases of unilateral inguinal hernia remains a controversial topic. The authors have been using the in-line laparoscopic technique of contralateral evaluation for unilateral inguinal hernia in children less than 2 years of age. Because of the case of the procedure and lack of morbidity, we decided to expand the use of this procedure up to age 8 years in January 2000. The purpose of this study is to evaluate if the incidence of contralateral hernia in children greater than 2 years justifies the procedure...
May 2004: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/15081371/multifaceted-pancreatic-mesenchymal-control-of-epithelial-lineage-selection
#18
Zhixing Li, Pradip Manna, Hiroyuki Kobayashi, Troy Spilde, Amina Bhatia, Barry Preuett, Krishna Prasadan, Mark Hembree, George K Gittes
Mouse pancreatic development is critically dependent on epithelial-mesenchymal interactions. The pancreas differs from other epithelial-mesenchymal organs in that the epithelium gives rise to both epithelial exocrine cells and non-epithelial endocrine cells. We studied the nature of the interactions between the epithelium and mesenchyme with respect to the decision between exocrine and endocrine lineages. We show here a tripartite influence of mesenchyme on the developing epithelium. First, close proximity or contact of mesenchyme with the epithelium induces exocrine differentiation...
May 1, 2004: Developmental Biology
https://www.readbyqxmd.com/read/15065023/aberrant-fibroblast-growth-factor-receptor-2-signalling-in-esophageal-atresia-with-tracheoesophageal-fistula
#19
Troy L Spilde, Amina M Bhatia, Sheilendra S Mehta, Mark J Hembree, Barry L Preuett, Daniel J Ostlie, Krishna Prasadan, Zhixing Li, Charles L Snyder, George K Gittes
BACKGROUND: Although the pathogenesis of esophageal atresia with tracheoesophageal fistula (EA/TEF) remains unknown, it has been shown that despite its esophageal appearance, the fistula tract originates from respiratory epithelium. The authors now hypothesize that defects in fibroblast growth factor (FGF) signaling contribute to the esophaguslike phenotype of the fistula tract. FGF2R is critical to normal lung morphogenesis and occurs in 2 isoforms (FGF2RIIIb and FGF2RIIIc), each with different ligand-binding specificity...
April 2004: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/12947339/defective-sonic-hedgehog-signaling-in-esophageal-atresia-with-tracheoesophageal-fistula
#20
Troy L Spilde, Amina M Bhatia, Sheilendra Mehta, Daniel J Ostlie, Mark J Hembree, Barry L Preuett, Krishna Prasadan, Zhixing Li, Charles L Snyder, George K Gittes
BACKGROUND: The pathogenesis of esophageal atresia and tracheoesophageal fistula (EA/TEF) remains unknown. We have found previously that an initial esophageal atresia, followed by an abnormal (absent) branching pattern of the middle branch of a trifurcation of the lung/tracheal bud, leads to the neonatal finding of TEF. Mice null mutant for hedgehog signaling can experience the development of EA/TEF, but the mechanism for this development is also unknown. Given that EA/TEF in humans appears not to be due to genetic defects, a hedgehog mutation cause seems very unlikely...
August 2003: Surgery
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