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Evaristo Ettorre, Francesco Saverio Bersani, Fabiola Colella, Adriana Servello, Amedeo Minichino, Valentina Megna, Mauro Liberatore, Massimo Biondi, Vincenzo Marigliano
It is described the case of a 74-years-old woman with probable Alzheimer Disease who showed good clinical response to rivastigmine associated with relevant improvement of cerebral perfusion after 1 year of treatment. The single-photon emission computed tomography (SPECT) scan showed a significant improvement in cortical uptake of the tracer in temporo-parietal and frontal regions in comparison to the examination performed before the treatment.
July 2015: Rivista di Psichiatria
Alexandra I Zugno, Ricardo Filipe Julião, Josiane Budni, Ana Maria Volpato, Daiane B Fraga, Felipe D Pacheco, Pedro F Deroza, Renata D Luca, Mariana B de Oliveira, Alexandra S Heylmann, João Quevedo
Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neurotransmitters such as dopamine, glutamate and acetylcholine. Recent studies suggest that rivastigmine (an acetylcholinesterase inhibitor) is important to improve the cognitive symptoms of schizophrenia...
September 2013: Metabolic Brain Disease
S Amici, A Lanari, R Romani, C Antognelli, V Gallai, L Parnetti
At present acetylcholinesterase (AChE) inhibitors (AChEIs) represent the only reliable therapeutic resource for symptomatic treatment of Alzheimer Disease (AD). This study was designed to assess the effects of 6-12 month treatment with AChEIs donepezil and rivastigmine on cerebrospinal fluid (CSF) AChE and butyrylcholinesterase (BuChE) activity in AD patients. The pattern of AChE isoforms (G4, G1, G2) before and after treatment was investigated as well. In AD patients treated with donepezil a significant increase of CFS AChE activity was observed, whereas treatment with rivastigmine induced a significant decrease of AChE activity...
November 2001: Mechanisms of Ageing and Development
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