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albumin and preeclampsia

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https://www.readbyqxmd.com/read/28008305/magnesium-sulfate-prevents-placental-ischemia-induced-increases-in-brain-water-content-and-cerebrospinal-fluid-cytokines-in-pregnant-rats
#1
Linda W Zhang, Junie P Warrington
Magnesium sulfate (MgSO4) is the most widely used therapy in the clinic to prevent the progression of preeclampsia, a hypertensive disorder of pregnancy, to eclampsia. Eclampsia, manifested as unexplained seizures and/or coma during pregnancy or postpartum, accounts for ~13% of maternal deaths worldwide. While MgSO4 continues to be used in the clinic, the mechanisms by which it exerts its protective actions are not well understood. In this study, we tested the hypothesis that MgSO4 protects against placental ischemia-induced increases in brain water content and cerebrospinal fluid cytokines...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27927648/renin-angiotensin-system-transgenic-mouse-model-recapitulates-pathophysiology-similar-to-human-preeclampsia-with-renal-injury-that-may-be-mediated-through-vegf
#2
J Morgan Denney, Cynthia E Bird, Annette Gendron-Fitzpatrick, Emmanuel Sampene, Ian M Bird, Dinesh M Shah
Using a transgenic cross, we evaluated features of preeclampsia, renal injury and the sFlt1/VEGF changes. Transgenic hAGT and hREN, or wild type (WT) C57Bl/6 mice were cross-bred: ♀hAGT x ♂hREN for preeclampsia (PRE) model and ♀WT x ♂WT for pregnant controls (WTP). Samples were collected for plasma VEGF, sFlt1 and urine albumin. Blood pressures (BP) were monitored by telemetry. Vascular reactivity was investigated by wire myography. Kidneys and placenta were immunostained for sFlt1 and VEGF. Eleven PRE and 9 WTP mice were compared...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27923282/ischaemia-modified-albumin-in-preeclampsia-a-critical-view
#3
Aslı Yarcı Gursoy, Elif Didem Ozdemir, Halis Ozdemir, Tuba Candar, Gamze Sinem Caglar
The aim of the study was to compare ischaemia-modified albumin (IMA) levels, both original and corrected, in healthy pregnancies and pregnancies complicated with preeclampsia. Maternal and cord blood samples from study (n = 16) and control (n = 17) groups were collected at the time of delivery. IMA levels were given in absorbance units (ABSU). IMA levels, both original and corrected, were compared between study and control groups. No significant difference was found between maternal and cord blood IMA levels between the study and control groups [1...
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27919602/hematocrit-and-plasma-albumin-levels-difference-may-be-a-potential-biomarker-to-discriminate-preeclampsia-and-eclampsia-in-patients-with-hypertensive-disorders-of-pregnancy
#4
Dong-Mei Dai, Jing Cao, Hong-Mei Yang, Hai-Mei Sun, Yu Su, Yuan-Yuan Chen, Xiao Fang, Wang-Bin Xu
BACKGROUND: We evaluated whether alterations of hemoglobin (HB), hematocrit (HCT), serum albumin level (ALB), and the difference of HCT and ALB can be used in the diagnosis of preeclampsia and eclampsia in patients with hypertensive disorders of pregnancy (HDP). METHODS: A total of 509 individuals were recruited and divided into 4 groups: Group 1, 170 healthy non-pregnant women; Group 2, 125 normal pregnant women; Group 3, 105 pregnant women diagnosed with gestational and chronic hypertension; Group 4, 109 pregnant women diagnosed as having preeclampsia and eclampsia...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27871550/carbetocin-for-prevention-of-postcesarean-hemorrhage-in-women-with-severe-preeclampsia-a-before-after-cohort-comparison-with-oxytocin
#5
B Nucci, Agm Aya, E Aubry, J Ripart
STUDY OBJECTIVE: The aim of the study was to compare the incidence of the use of additional uterotonics before and after the change of carbetocin to oxytocin for the prevention of postpartum hemorrhage after cesarean delivery in women with severe preeclampsia. DESIGN: This was an observational retrospective before-and-after study. SETTING: Operating room, postoperative recovery area. PATIENTS: Sixty women with severe preeclampsia undergoing cesarean delivery under spinal anesthesia; American Society of Anesthesiologists 3...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27754103/os-21-08-novel-reduced-uterine-perfusion-pressure-rupp-model-of-preeclampsia-in-mice
#6
Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is a pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. A reduction in uterine blood flow causes placental ischemia and placental release of anti-angiogenic factors such as soluble fms-like tyrosine kinase (sFlt-1) followed by PE. Although the reduced uterine perfusion pressure (RUPP) model is widely used in rats, investigating the genetics of PE has been problematic because it has been difficult to make a useful RUPP model in mice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643028/os-21-08-novel-reduced-uterine-perfusion-pressure-rupp-model-of-preeclampsia-in-mice
#7
Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
OBJECTIVE: Preeclampsia (PE) is a pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. A reduction in uterine blood flow causes placental ischemia and placental release of anti-angiogenic factors such as soluble fms-like tyrosine kinase (sFlt-1) followed by PE. Although the reduced uterine perfusion pressure (RUPP) model is widely used in rats, investigating the genetics of PE has been problematic because it has been difficult to make a useful RUPP model in mice...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508762/-op-5d-06-hypertension-as-a-paternal-factor-influences-maternal-adaptation-to-pregnancy-and-is-associated-with-placental-insufficiency-and-fetal-growth-restriction
#8
G Barrientos, A Uceda, A Sgariglia, G Giardina, S M Blois, J E Toblli
OBJECTIVE: Severe forms of hypertensive disorders of pregnancy, like early-onset preeclampsia (PE), are often linked with abnormal placentation. Genetic factors contributed by the father may be important for placental development, and previous studies support the existence of a paternal component for PE and fetal growth restriction. Thus, the present study was conducted to evaluate the influence of arterial hypertension as a paternal factor on placental development and fetal growth in normal female rats...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27491315/prevalence-of-chronic-kidney-disease-after-preeclampsia
#9
Veronica Agatha Lopes van Balen, Julia Jeltje Spaan, Tom Cornelis, Marc Erich August Spaanderman
BACKGROUND: Preeclampsia (PE), an endothelial disease that affects kidney function during pregnancy, is correlated to an increased future risk of cardiovascular and chronic kidney disease. The Kidney Disease Improving Global Outcomes (KDIGO) 2012 guideline emphasizes the combined role of glomerular filtration rate (GFR) and albuminuria in determining the frequency of monitoring of kidney function. OBJECTIVES: In this study we evaluated the prevalence of CKD in women with a history of PE...
August 5, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27292175/preeclampsia-prediction-in-type-1-diabetes-and-diurnal-blood-pressure-methodology
#10
REVIEW
Finn Friis Lauszus
The most recent Cochrane reviews on oral antihypertensive drugs in pregnancy conclude that no substantial benefits for the mother or fetus are demonstrated so far. Whether this applies for a high-risk and diabetic pregnancy is doubtful. The aim of this short review is an introduction to the field of ambulatory blood pressure measurements in pregnancy and in particular in women with type 1 diabetes. Diabetic pregnancy is complicated with a 50% risk of hypertension/preeclampsia. In the nonpregnant, diabetic women minute increases in blood pressure as well as in albuminuria are forerunners for incipient and overt nephropathy...
2016: Current Hypertension Reviews
https://www.readbyqxmd.com/read/27187738/reduced-uterine-perfusion-pressure-rupp-model-of-preeclampsia-in-mice
#11
Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Toshiyuki Hayase, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
Preeclampsia (PE) is a pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. A reduction in uterine blood flow causes placental ischemia and placental release of anti-angiogenic factors such as sFlt-1 followed by PE. Although the reduced uterine perfusion pressure (RUPP) model is widely used in rats, investigating the role of genes on PE using genetically engineered animals has been problematic because it has been difficult to make a useful RUPP model in mice. To establish a RUPP model of PE in mice, we bilaterally ligated ovarian vessels distal to ovarian branches, uterine vessels, or both in ICR-strain mice at 14...
2016: PloS One
https://www.readbyqxmd.com/read/26954342/cyclosporin-a-significantly-improves-preeclampsia-signs-and-suppresses-inflammation-in-a-rat-model
#12
Bihui Hu, Jinying Yang, Qian Huang, Junjie Bao, Shaun Patrick Brennecke, Huishu Liu
Preeclampsia is associated with an increased inflammatory response. Immune suppression might be an effective treatment. The aim of this study was to examine whether Cyclosporin A (CsA), an immunosuppressant, improves clinical characteristics of preeclampsia and suppresses inflammation in a lipopolysaccharide (LPS) induced preeclampsia rat model. Pregnant rats were randomly divided into 4 groups: group 1 (PE) rats each received LPS via tail vein on gestational day (GD) 14; group 2 (PE+CsA5) rats were pretreated with LPS (1...
May 2016: Cytokine
https://www.readbyqxmd.com/read/26867056/prostasin-and-matriptase-st14-in-placenta-from-preeclamptic-and-healthy-pregnant-women
#13
Britta Frederiksen-Møller, Jan S Jørgensen, Mie R Hansen, Oliver Krigslund, Lotte K Vogel, Louise B Andersen, Boye L Jensen
OBJECTIVE: Preeclampsia is characterized by disturbed placentation, hypertension, proteinuria, and suppression of plasma renin, angiotensin II, and aldosterone. Regulated activity of tissue serine proteases, prostasin, and matriptase is necessary for normal placental development in mice. Prostasin activates the renal epithelial sodium channel. We hypothesized that preeclampsia is associated with low prostasin expression in placenta and spillover of prostasin into urine across the defect glomerular barrier...
February 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26763855/immune-activation-during-the-implantation-phase-causes-preeclampsia-like-symptoms-via-the-cd40-cd40-ligand-pathway-in-pregnant-mice
#14
Keiichi Matsubara, Yuko Matsubara, Miki Mori, Yuka Uchikura, Katsuyuki Hamada, Toru Fujioka, Hisashi Hashimoto, Takashi Matsumoto
The CD40 ligand (CD40L) is expressed by T cells and has a critical role in immune system regulation. Interventions targeting CD40L interactions following embryo implantation represent an approach to preventing preeclampsia (PE). To better understand the role of CD40L in PE, we developed a PE mouse model in which we examined how CD40L-induced immune activation affects embryo implantation. Blastocysts were incubated with CD40L-expressing adenovirus and then were transferred into the uterine horns of pseudopregnant ICR mice...
January 14, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/26636373/ischemia-modified-albumin-ima-a-novel-marker-for-preeclampsia-independent-of-uterine-artery-notching-identified-by-doppler-ultrasound
#15
Keziban Doğan, Hakan Guraslan, Atilla Çankaya, Hediye Dağdeviren, Murat Ekin
OBJECTIVE: To determine the predictive value of second trimester serum ischemia-modified albumin (IMA) levels for preeclampsia (PE), small for gestational age (SGA) and gestational diabetes mellitus (GDM). METHODS: The study was conducted at a tertiary care hospital between May and August 2014. Healthy pregnant women (n = 88) who were screened for fetal anomalies with ultrasound at 20-24 weeks of gestation were included in the study. Doppler measurements of the bilateral uterine arteries were performed in all the patients...
November 2015: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/26636109/maternal-serum-ischemia-modified-albumin-as-a-marker-for-hypertensive-disorders-of-pregnancy-a-pilot-study
#16
Sapna Vyakaranam, Aparna Varma Bhongir, Dakshayani Patlolla, Rekha Chintapally
BACKGROUND: Hypoxia driven oxidative stress of the placenta contributes to the pathogenesis of preeclampsia. Serum Ischemia Modified Albumin (IMA) has recently emerged as an oxidative stress marker, used in diagnosis of cardiac ischemia. Aim: To determine the efficiency of serum IMA in differentiating hypertensive disorders of pregnancy (pregnancy induced hypertension, preeclampsia) from normal pregnancy. METHODS: It was a case control study. Pregnant women ≥32 weeks of gestation...
June 2015: International Journal of Reproduction, Contraception, Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26622198/a-comparison-of-serum-levels-of-25-hydroxy-vitamin-d-in-pregnant-women-at-risk-for-gestational-diabetes-mellitus-and-women-without-risk-factors
#17
Lobat Jafarzadeh, Akram Motamedi, Masoud Behradmanesh, Raziyeh Hashemi
BACKGROUND: During pregnancy, Low serum 25-hydroxyvitamin-D [25(OH)D] concentration is even more critical. This deficiency leads to higher incidences of preeclampsia, gestational diabetes, preterm birth, bacterial vaginosis, and also affects the health of the infants. The aim of this study was to evaluate the relationships between serum levels of 25-hydroxyvitamin D (25[OH]D) and gestational diabetes mellitus (GDM) and differences in high-risk pregnant women and women without risk factors for GDM...
October 2015: Materia Socio-medica
https://www.readbyqxmd.com/read/26597745/microalbuminuria-is-a-predictor-of-adverse-pregnancy-outcomes-including-preeclampsia
#18
COMPARATIVE STUDY
M Jayaballa, S Sood, I Alahakoon, S Padmanabhan, N W Cheung, V Lee
OBJECTIVES: Abnormal urinary protein loss is a marker associated with a diverse range of renal diseases including preeclampsia. Current measures of urine protein used in the diagnostic criteria for the diagnosis of preeclampsia includes urine protein:creatinine ratio and 24-h urine protein. However very little is known about the value of urine albumin:creatinine ratio (uACR) in pregnancy. In this study we examined the prognostic value of microalbuminuria detected antepartum to predict adverse pregnancy outcomes...
October 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26407501/glucocorticoid-exposure-in-early-placentation-induces-preeclampsia-in-rats-via-interfering-trophoblast-development
#19
Dongxin Zhang, Haojing Liu, Ji Zeng, Xili Miao, Wei Huang, Hongxiang Chen, Yinping Huang, Yongsheng Li, Duyun Ye
In pregnancy, placenta can be exposed to glucocorticoids (GCs) via several ways, which may disturb placentation and adversely affect pregnancy. Preeclampsia (PE) is thought to be attributed, in part, to impaired trophoblast development. The purpose of the present study was to confirm that GC exposure in early placentation could lead to PE in rats, with the mechanisms involving dysregulated trophoblast development. In the study, pregnant rats were administered with 2.5mg/kg Dex subcutaneously once per day from gestational day 7 to 13...
January 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/26351026/aerobic-exercise-training-in-formerly-preeclamptic-women-effects-on-venous-reserve
#20
Ralph R Scholten, Maria T E Hopman, Fred K Lotgering, Marc E A Spaanderman
UNLABELLED: In women with a history of preeclampsia, low plasma volume (≤1373 mL/m(2)) is associated with recurrent preeclampsia and chronic hypertension. Interventions that improve volume reserve may reduce these risks in formerly preeclamptic women. In this study, we examined the effects of aerobic exercise training on venous reserves in 24 normotensive formerly preeclamptic women and 20 controls. Before and after 12-week aerobic exercise training, we measured plasma volume with albumin indicator dilution technique and venous compliance with venous occlusion plethysmography...
November 2015: Hypertension
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