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albumin and preeclampsia

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https://www.readbyqxmd.com/read/29674190/urinary-angiotensinogen-excretion-in-australian-indigenous-and-non-indigenous-pregnant-women
#1
Kirsty G Pringle, Celine Corbisier de Meaultsart, Shane D Sykes, Loretta J Weatherall, Lyniece Keogh, Don C Clausen, Gus A Dekker, Roger Smith, Claire T Roberts, Kym M Rae, Eugenie R Lumbers
The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. The excretion of RAS proteins was measured in non-Indigenous and Indigenous Australian women with uncomplicated or complicated pregnancies (preeclampsia, diabetes/gestational diabetes, proteinuria/albuminuria, hypertension, small/large for gestational age, preterm birth), and in non-pregnant non-Indigenous women...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29570915/ischemia-modified-albumin-in-preterm-infants-born-to-mothers-with-preeclampsia
#2
Özmert M A Özdemir, Emine Özdemir, Yaşar Enli, Özer Öztekin, Hacer Ergin
BACKGROUND: Preeclampsia (PE) is at increased risk for maternal and/or fetal mortality or serious morbidity. PE is associated with ischemia and increased oxidative stress in placenta, which may lead to modification of plasma albumin to ischemia-modified-albumin (IMA). We aimed to investigate of IMA and hematological parameters in premature infants born to mothers with normal pregnancy and preeclampsia, and also in their mothers. METHODS: Twentyfive pregnants with PE and their premature newborns as PE-group, and 25 normotensive pregnants and their premature newborns as control-group were included the study...
March 23, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29523278/predictors-of-oedema-type-in-reversible-posterior-leukoencephalopathy-syndrome-with-preeclampsia-or-eclampsia
#3
Xiao-Bo Fang, Dun-Jin Chen, Fang He, Jia Chen, Zhou Zhou, Yan-Ling Liang, Wei-Xi Zhang
OBJECTIVE: To explore the predictive factors of oedema types in reversible posterior leukoencephalopathy syndrome (RPLS) with preeclampsia (PE) and eclampsia, which is closely related to reversible lesions and clinical recovery. METHOD: We collected data from 44 consecutive patients diagnosed with RPLS in PE or eclampsia between 2013 and 2017. All patients were classified into vasogenic oedema (n = 31) or cytotoxic oedema (n = 13) groups according to magnetic resonance imaging (MRI) results...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29513563/chronic-hypertension-in-pregnancy-the-impact-of-ethnicity-and-superimposed-preeclampsia-on-placental-endothelial-and-renal-biomarkers
#4
Louise Mary Webster, Carolyn Gill, Paul T Seed, Kate Bramham, Cornelia Wiesender, Catherine Nelson-Piercy, Jenny E Myers, Lucy C Chappell
Black ethnicity is associated with worse pregnancy outcomes in women with chronic hypertension. Pre-existing endothelial and renal dysfunction, and poor placentation may contribute but pathophysiological mechanisms underpinning increased risk are poorly understood. This cohort study aimed to investigate the relationship between ethnicity, superimposed pre-eclampsia and longitudinal changes in markers of endothelial, renal and placental dysfunction in women with chronic hypertension. Plasma concentrations of placental growth factor (PlGF), syndecan-1, renin, aldosterone, and urinary angiotensinogen:creatinine ratio (AGTCR), protein:creatinine ratio (PCR) and albumin:creatinine ratio (ACR) were quantified during pregnancy and postpartum in women with chronic hypertension...
March 7, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29325458/a-diagnostic-test-accuracy-meta-analysis-of-maternal-serum-ischemia-modified-albumin-for-detection-of-preeclampsia
#5
Varikasuvu Seshadri Reddy, Manne Munikumar, Pragathi Duggina, Neelakant Varma
BACKGROUND/AIMS: Ischemia-modified albumin (IMA) has been widely accepted as a serological biomarker. IMA has been proposed as a simple and novel marker of oxidative stress in preeclampsia (PE). This systematic review and diagnostic test accuracy meta-analysis aims to evaluate the diagnostic accuracy of this novel serological biomarker, IMA to detect PE. METHODS: A systematic search of major databases was performed to identify all published diagnostic accuracy studies on IMA...
January 24, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29305116/urine-albumin-is-a-superior-predictor-of-preeclampsia-compared-to-urine-plasminogen-in-type-i-diabetes-patients
#6
Lise Hald Nielsen, Boye L Jensen, Jens Fuglsang, Lise Lotte Torvin Andersen, Dorte Møller Jensen, Jan Stener Jørgensen, Gitte Kitlen, Per Ovesen
Pregnant women with type I diabetes mellitus (T1DM) are at increased risk of developing preeclampsia (PE). Plasminogen is aberrantly filtrated from plasma into tubular fluid in PE patients and activated to plasmin. Plasmin activates the epithelial sodium channel in the collecting ducts potentially causing impaired sodium excretion, suppression of the renin-angiotensin-aldosterone system, and hypertension in PE. The objective of the study was to test whether urinary total plasmin(ogen)/creatinine ratio and plasma concentration of aldosterone were better predictors of PE in pregnant women with T1DM compared with urine albumin and haemoglobin A1C ...
February 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29126987/endothelial-and-kidney-function-in-women-with-a-history-of-preeclampsia-and-healthy-parous-controls-a-case-control-study
#7
Veronica A Lopes van Balen, Julia J Spaan, Tom Cornelis, Wieteke M Heidema, Ralph R Scholten, Marc E A Spaanderman
INTRODUCTION: Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum endothelial dysfunction often persists in these women. We postulate that in women with a history of PE reduced endothelial dependent vasodilation coincides with attenuated kidney function, as both reflect endothelial dysfunction. METHODS: We assessed endothelial and kidney function in women with a history of PE (n=79) and uncomplicated pregnancies (n=49) at least 4years postpartum...
March 2018: Microvascular Research
https://www.readbyqxmd.com/read/28817994/maternal-serum-and-fetal-cord-blood-ischemia-modified-albumin-concentrations-in-normal-pregnancy-and-preeclampsia-a-systematic-review-and-meta-analysis
#8
Varikasuvu Seshadri Reddy, Pragathi Duggina, Mrudula Vedhantam, Munikumar Manne, Neelakant Varma, Srinivas Nagaram
BACKGROUND/AIMS: A meta-analysis of maternal serum ischemia-modified albumin (IMA) and fetal cord-blood IMA concentrations in normal pregnancy (NP) compared to non-pregnant healthy controls (HC) and in preeclampsia (PE) compared with normal pregnant controls were studied. METHODS: All major databases were searched for eligible studies. We included eight studies comparing serum IMA between NP and HC, 14 studies comparing serum IMA between PE and NP and five studies comparing cord-blood IMA between PE and NP groups...
August 29, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28808694/human-serum-albumin-and-oxidative-stress-in-preeclamptic-women-and-the-mechanism-of-albumin-for-stress-reduction
#9
Hiroyuki Kinoshita, Kazushi Watanabe, Toshiharu Azma, Guo-Gang Feng, Takahiko Akahori, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Akihiko Wakatsuki
AIMS: The present study to address one of the mechanisms in preeclampsia, examined whether levels of oxidative stress, human serum albumin, and endothelial function correlate in pregnant women and whether human serum albumin reduces levels of superoxide produced by NADPH oxidase activation in the human vascular smooth muscle cells. MATERIALS AND METHODS: Pregnant women with (Preeclampsia group, n = 33) and without preeclampsia (Normal group, n = 37) were recruited to determine levels of reactive oxygen species (serum diacron-reactive oxygen metabolite [d-ROM]), and the flow-mediated dilation (FMD)...
August 2017: Heliyon
https://www.readbyqxmd.com/read/28781906/cystatin-c-as-a-marker-for-renal-impairment-in-preeclampsia
#10
Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet, Kashyap Dahal
Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women)...
2017: Journal of Biomarkers
https://www.readbyqxmd.com/read/28747409/spot-urine-protein-measurements-in-normotensive-pregnancies-pregnancies-with-isolated-proteinuria-and-preeclampsia
#11
Andrea Kattah, Natasa Milic, Wendy White, Vesna Garovic
We performed a prospective, longitudinal study of pregnant women presenting to their first obstetrics visits to characterize the changes in spot urine protein-to-creatinine (UPCR) and albumin-to-creatinine ratios (UACR) in normotensive pregnancies, as well as identify clinical characteristics associated with isolated proteinuria and preeclampsia. We measured spot urinary albumin, protein, and creatinine at the first prenatal visit, end of the second trimester, and at delivery. In the normotensive pregnancies (n = 142), we found that from the beginning of pregnancy to delivery, UACR increased by a median [interquartile range (IQR)] of 14...
October 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28706364/prediction-of-preeclampsia-in-early-pregnancy-by-estimating-the-spot-urinary-albumin-creatinine-ratio
#12
Nupur Gupta, Taru Gupta, Deepti Asthana
OBJECTIVE: To assess whether a spot urinary albumin:creatinine ratio (ACR) measured before 20 weeks of gestation can predict subsequent development of preeclampsia. METHODS: The ACR was determined from midstream urine sample taken between 17 and 20 weeks of gestation. Urine albumin was measured by immunoturbidimetric method using commercially available kit (Beckman Coulter) through Beckman AU 480 fully automated biochemistry analyzer. Urine creatinine was measured by modified kinetic Jaffe reaction without deproteinization...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28672944/effective-prediction-of-preeclampsia-by-measuring-serum-angiotensin-ii-urinary-angiotensinogen-and-urinary-transforming-growth-factor-%C3%AE-1
#13
Lihong Zhang, Yunjiao Zhou, Qing Wu, Weifeng Fan, Jun Ye, Yaping Chen, Yun Wu, Jianying Niu, Yong Gu
The aim of the current study was to analyze serum angiotensin II (Ang II), urinary angiotensinogen (AGT) and urinary transforming growth factor β1 (TGFβ1) levels in relation to the clinical manifestation of preeclampsia, and to explore the effects of circulating and renal renin angiotensin system (RAS) in preeclampsia patients. An enzyme-linked immunosorbent assay was used to evaluate serum Ang II, urinary AGT and urinary TGFβ1 in preeclampsia, pregnancy-induced hypertension and normotensive pregnancy patients...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28534011/is-massive-proteinuria-associated-with-maternal-and-fetal-morbidities-in-preeclampsia
#14
Mi Jung Kim, Young Nam Kim, Eun Jung Jung, Hye Ree Jang, Jung Mi Byun, Dae Hoon Jeong, Moon Su Sung, Kyung Bok Lee, Ki Tae Kim
OBJECTIVE: The aim of this study was to investigate whether massive proteinuria in preeclampsia is associated with maternal and fetal complications. METHODS: We retrospectively analyzed the clinical records of 233 patients who were diagnosed with preeclampsia. We divided the preeclamptic patients into three groups based on the amount of proteinuria: massive (≥5 g/24 hr), moderate (2 to 5 g/24 hr) and mild (<2 g/24 hr) proteinuria group. We analyzed the clinical characteristics and maternal and neonatal complications among three groups...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28428695/increased-oxidatively-modified-forms-of-albumin-in-association-with-decreased-total-antioxidant-activity-in-different-types-of-hypertensive-disorders-of-pregnancy
#15
Jyothi M P D'souza, Sindhu Harish, Vinitha Ramanath Pai, Chitra Shriyan
Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28428691/relationship-between-xanthine-oxidase-ischemia-modified-albumin-nitric-oxide-with-antioxidants-in-non-pregnants-pre-and-post-delivery-of-normal-pregnants-and-preeclampsia
#16
Vanishree Bambrana, C D Dayanand, Pushpa Kotur
Preeclampsia is a multisystem disorder involves altered homeostasis of oxidants-antioxidants, inflammatory process and endothelial dysfunction. The present study aim was to determine the levels of oxidative stress parameters (malondialdehyde, protein carbonyl, ischemia modified albumin and xanthine oxidase), nutrient antioxidants (vitamin C and vitamin E), enzyme antioxidants (catalase, superoxide dismutase, glutathione peroxidase glutathione reductase), total antioxidant status (TAS) and its association with nitric oxide...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-preeclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#17
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction (FGR)...
July 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28384941/massive-ascites-and-pleural-effusion-in-preeclampsia
#18
Sezen Bozkurt Koseoglu, Ruya Deveer, Aysun Camuzcuoglu, Burcu Kasap, Hakan Camuzcuoglu
Preeclampsia is defined as new onset hypertension and proteinuria after 20 weeks of gestation and complicates approximately 2-8% of all pregnancies. Release of vasoconstrictive agents, endothelial damage, hyperpermeability of the capillaries and microangiopathic haemolysis involves the basic pathophysiology. It has variable clinical presentation. Here, we report a case of severe preeclampsia who developed postpartum massive ascites and pleural effusion. Primigravid patient was admitted to our clinic at 35 weeks of gestation with very high blood pressure...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28282767/pulmonary-edema-in-preeclampsia-an-indonesian-case-control-study
#19
Manggala Pasca Wardhana, Erry Gumilar Dachlan, Gustaaf Dekker
OBJECTIVE: To analyze risk factors, obstetric outcome and the need for mechanical ventilation in preeclampsia complicated by pulmonary edema. MATERIALS AND METHODS: Case-control study using medical record on preeclampsia complicated by pulmonary edema patients in East Java tertiary referral hospital over 2 years. A simple scoring system was developed to predict the need for mechanical ventilation, using logistic regression. RESULTS: 1106 cases of preeclampsia were admitted, with 62 cases (5...
March 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28161064/dysregulation-of-maternal-and-placental-vitamin-d-metabolism-in-preeclampsia
#20
J A Tamblyn, R Susarla, C Jenkinson, L E Jeffery, O Ohizua, R F Chun, S Y Chan, M D Kilby, M Hewison
INTRODUCTION: Epidemiology has linked preeclampsia (PET) to decreased maternal serum 25-hydroxyvitamin D3 (25(OH)D3). However, alterations in systemic and placental/decidual transport and metabolism of 25(OH)D3 during pregnancy suggest that other forms of vitamin D may also contribute to the pathophysiology of PET. METHODS: In a cross sectional analysis of normal pregnant women at 1st (n = 25) and 3rd trimester (n = 21), pregnant women with PET (n = 22), and non-pregnant female controls (n = 20) vitamin D metabolites were quantified in paired maternal serum, placental, and decidual tissue...
February 2017: Placenta
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