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Return of spontaneous circulation

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https://www.readbyqxmd.com/read/29328448/association-between-ace2-ace-balance-and-pneumocyte-apoptosis-in-a-porcine-model-of-acute-pulmonary-thromboembolism-with-cardiac-arrest
#1
Hong-Li Xiao, Lian-Xing Zhao, Jun Yang, Nan Tong, Le An, Qi-Tong Liu, Miao-Rong Xie, Chun-Sheng Li
Acute pulmonary embolism (APE) is frequently reported in patients with cardiac arrest (CA) in emergency care. Pneumocyte apoptosis is commonly observed in the lungs following an APE. An important pathological mechanism evoking apoptosis during a lipopolysaccharide‑induced acute lung injury is the angiotensin‑converting enzyme 2 (ACE2)/ACE imbalance. The present study uses a porcine model to examine the anti‑apoptotic effects of captopril on APE‑CA and the return of spontaneous circulation (ROSC). Pigs were randomly assigned into four groups: Control, APE‑CA, ROSC‑saline, and ROSC‑captopril...
January 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29323039/neuronal-injury-and-tumor-necrosis-factor-alpha-immunoreactivity-in-the-rat-hippocampus-in-the-early-period-of-asphyxia-induced-cardiac-arrest-under-normothermia
#2
Hyun-Jin Tae, Il Jun Kang, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Myoung Cheol Shin, Yoon Sung Kim, Jun Hwi Cho, Jong-Dai Kim, Ji Hyeon Ahn, Joon Ha Park, In-Shik Kim, Hyang-Ah Lee, Yang Hee Kim, Moo-Ho Won, Young Joo Lee
Low survival rate occurs in patients who initially experience a spontaneous return of circulation after cardiac arrest (CA). In this study, we induced asphyxial CA in adult male Sprague-Daley rats, maintained their body temperature at 37 ± 0.5°C, and then observed the survival rate during the post-resuscitation phase. We examined neuronal damage in the hippocampus using cresyl violet (CV) and Fluore-Jade B (F-J B) staining, and pro-inflammatory response using ionized calcium-binding adapter molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), and tumor necrosis factor-alpha (TNF-α) immunohistochemistry in the hippocampus after asphyxial CA in rats under normothermia...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29321118/a-comparison-of-carotid-doppler-ultrasonography-and-capnography-in-evaluating-the-efficacy-of-cardiopulmonary-resuscitation-the-first-study
#3
Gökhan Yilmaz, Mustafa Silcan, Süha Serin, Bahadır Caglar, Özkan Erarslan, İsmet Parlak
INTRODUCTION AND PURPOSE: The end-tidal carbon dioxide (ETCO2) measurement is accepted as the gold standard method for assessing cardiopulmonary resuscitation (CPR) efficacy. In recent studies, the use of Carotid Doppler Ultrasonography has become widespread in showing CPR efficacy. In the present study, the carotid blood flow measurement was compared with ETCO2 measurement and an evaluation was made of whether this method could be used as an alternative method to capnography in the assessment of CPR efficacy...
January 6, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29317989/erythropoietin-therapy-after-out-of-hospital-cardiac-arrest-a-systematic-review-and-meta-analysis
#4
Rahul Chaudhary, Jalaj Garg, Parasuram Krishnamoorthy, Kevin Bliden, Neeraj Shah, Nayan Agarwal, Rahul Gupta, Abhishek Sharma, Karl B Kern, Nainesh C Patel, Paul Gurbel
AIM: To assess safety and efficacy of early erythropoietin (Epo) administration in patients with out-of-hospital cardiac arrest (OHCA). METHODS: A systematic literature search was performed using PubMed, MEDLINE, EMBASE, EBSCO, CINAHL, Web of Science and Cochrane databases, of all studies published from the inception through October 10, 2016. Inclusion criteria included: (1) Adult humans with OHCA and successful sustained return of spontaneous circulation; and (2) studies including mortality/brain death, acute thrombotic events as their end points...
December 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29317350/duration-of-cardiopulmonary-resuscitation-in-patients-without-prehospital-return-of-spontaneous-circulation-after-out-of-hospital-cardiac-arrest-results-from-a-severity-stratification-analysis
#5
Akira Funada, Yoshikazu Goto, Hayato Tada, Ryota Teramoto, Masaya Shimojima, Kenshi Hayashi, Masa-Aki Kawashiri, Masakazu Yamagishi
BACKGROUND: The relationship between duration of cardiopulmonary resuscitation (CPR) and post-arrest outcomes based on severity stratification in out-of-hospital cardiac arrest (OHCA) patients without prehospital return of spontaneous circulation (ROSC) remains unclear. METHODS: We analysed 420,959 adult patients without prehospital ROSC in the All-Japan OHCA registry for 4 years. Prehospital CPR duration was defined as the time from CPR initiation by emergency medical service (EMS) providers to hospital arrival...
January 6, 2018: Resuscitation
https://www.readbyqxmd.com/read/29317152/predicting-long-term-outcomes-after-cardiac-arrest-by-using-serum-neutrophil-gelatinase-associated-lipocalin
#6
Yu-Ri Park, Joo Suk Oh, Hyunho Jeong, Jungtaek Park, Young Min Oh, Semin Choi, Kyoung Ho Choi
OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by various tissues in pathologic states. Previous studies reported that post-cardiac arrest serum NGAL levels correlate with short-term neurologic outcomes and survival. The aim of this study was to examine the associations between NGAL levels post-cardiac arrest and long-term outcomes and survival. METHODS: This prospective observational study and retrospective review included adult out-of-hospital cardiac arrest survivors who were treated by hypothermia-targeted temperature management...
December 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29313566/factors-influencing-high-quality-chest-compressions-during-cardiopulmonary-resuscitation-scenario-according-to-2015-american-heart-association-guidelines
#7
Halla Kaminska, Wojciech Wieczorek, Pawel Matysiuk, Lukasz Czyzewski, Jerzy Robert Ladny, Jacek Smereka, Krzysztof J Filipiak, Lukasz Szarpak
BACKGROUND AND AIM: Recent American Heart Association Guidelines from 2010 and 2015 year stressed the importance of high quality chest compression and define standards for compression rate, depth, recoil and maximal acceptable time for interruptions. High - quality cardiopulmonary resuscitation (CPR) is the "cornerstone" of a system of care that can optimize outcomes beyond return of spontaneous circulation Methods: 100 medical students were enrolled to the study. Study participants after Basic Life Support Course according to American Heart Association 2015 guidelines performed 2-min cardiopulmonary resuscitation on Resusci Anne® QCPR Manikin...
January 9, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29306263/admission-levels-of-high-density-lipoprotein-and-apolipoprotein-a-1-are-associated-with-the-neurologic-outcome-in-patients-with-out-of-hospital-cardiac-arrest
#8
Yong Soo Son, Kyung Su Kim, Gil Joon Suh, Woon Yong Kwon, Min Ji Park, Jung In Ko, Taegyun Kim
OBJECTIVE: To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA). METHODS: This was a retrospective observational study conducted in a single tertiary hospital intensive care unit. All adult OHCA survivors with admission lipid profiles were enrolled from March 2013 to December 2015...
December 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29305251/cardiac-arrest-during-pregnancy-ongoing-clinical-conundrum-an-expert-review
#9
REVIEW
Carolyn M Zelop, Sharon Einav, Jill M Mhyre, Stephanie Martin
While global maternal mortality has decreased in the last 25 years, the maternal mortality ratio in the United States has actually increased. Maternal mortality is a complex phenomenon involving multifaceted socioeconomic and clinical parameters including inequalities in access to health care, racial and ethnic disparities, maternal comorbidities and epidemiologic ascertainment bias. Escalating maternal mortality underscores the importance of clinician preparedness to respond to maternal cardiac arrest that may occur in any maternal health care setting...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29302698/out-of-hospital-airway-management-during-manual-compression-or-automated-chest-compression-devices-a%C3%A2-registry-based-analysis
#10
M Bernhard, N H Behrens, J Wnent, S Seewald, S Brenner, T Jantzen, A Bohn, J T Gräsner, M Fischer
BACKGROUND: Airway management during resuscitation is pivotal for treating hypoxia and inducing reoxygenation. This German Resuscitation Registry (GRR) analysis investigated the influence of the type of airway used in patients treated with manual chest compression (mCC) and automated chest compression devices (ACCD) after out-of-hospital cardiac arrest (OHCA). METHODS: Out of 42,977 patients (1 January 2010-30 June 2016) information on outcome, airway management and method of chest compressions were available for 27,544 patients...
January 4, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29291538/tension-pneumoperitoneum-after-bystander-cardiopulmonary-resuscitation-a-case-report
#11
Sherry Johnson, Jessica McCracken, Fadi Baidoun
INTRODUCTION: Abdominal visceral injuries after cardiopulmonary resuscitation (CPR) are infrequent though can be significant complications of CPR requiring invasive interventions. We present a case of a gastric perforation as a result of bystander CPR. This resulted in tension pneumoperitoneum necessitating abdominal decompression prior to laparotomy and repair. PRESENTATION OF CASE: 37-year-old female complained of abdominal pain and distension after return of spontaneous circulation from successful CPR following a drug overdose and cardiopulmonary arrest...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29284836/cardiopulmonary-resuscitation-evaluation-of-knowledge-efficacy-and-retention-in-young-doctors-joining-postgraduation-program
#12
Vidhu Bhatnagar, Urvashi Tandon, Kavitha Jinjil, Deepak Dwivedi, S Kiran, Rohit Verma
Background: High-quality cardiopulmonary resuscitation (CPR) and rapid defibrillation the cornerstone for resuscitation from cardiac arrest and increase the incidence of return of spontaneous circulation. Regular CPR training imparted to health-care personnel increases knowledge and helps in skill enhancing. Aims: The aim of this study is to evaluate background knowledge, percentage improvement in the skills, and residual knowledge after a period of 6 months of postgraduate (PG) students as well as the efficacy of the designed teaching program for CPR...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29283979/inhibition-of-rho-kinase-by-fasudil-attenuates-ischemic-lung-injury-after-cardiac-arrest-in-rats
#13
Jian Wei, Peng Wang, Yi Li, Qingli Dou, Jiali Lin, Wuyuan Tao, Jinle Lin, Xuan Fu, Zitong Huang, Wenwu Zhang
Lung injury is a common complication after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR), and Rho kinase (ROCK) may be involved in the process of this injury. In this study, we aimed to study the effects of ROCK inhibition by fasudil on lung injury induced by asphyxial CA and CPR in rats. A total of 130 rats were randomized into three groups: Sham, Control, and Fasudil intervention group. Animals in the Fasudil intervention group were intraperitoneally administered with 10 mg/kg of the drug, 1 h before inducing CA...
December 27, 2017: Shock
https://www.readbyqxmd.com/read/29283290/real-time-quantitative-monitoring-of-cerebral-blood-flow-by-laser-speckle-contrast-imaging-after-cardiac-arrest-with-targeted-temperature-management
#14
Junyun He, Hongyang Lu, Leanne Young, Ruoxian Deng, Daniel Callow, Shanbao Tong, Xiaofeng Jia
Brain injury is the main cause of mortality and morbidity after cardiac arrest (CA). Changes in cerebral blood flow (CBF) after reperfusion are associated with brain injury and recovery. To characterize the relative CBF (rCBF) after CA, 14 rats underwent 7 min asphyxia-CA and were randomly treated with 6 h post-resuscitation normothermic (36.5-37.5℃) or hypothermic- (3-234℃) targeted temperature management (TTM) (N = 7). rCBF was monitored by a laser speckle contrast imaging (LSCI) technique. Brain recovery was evaluated by neurologic deficit score (NDS) and quantitative EEG - information quantity (qEEG-IQ)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29282149/the-effect-of-angiotensin-ii-on-blood-pressure-in-patients-with-circulatory-shock-a-structured-review-of-the-literature
#15
Laurence W Busse, Michael T McCurdy, Osman Ali, Anna Hall, Huaizhen Chen, Marlies Ostermann
BACKGROUND: Circulatory shock is a common syndrome with a high mortality and limited therapeutic options. Despite its discovery and use in clinical and experimental settings more than a half-century ago, angiotensin II (Ang II) has only been recently evaluated as a vasopressor in distributive shock. We examined existing literature for associations between Ang II and the resolution of circulatory shock. METHODS: We searched PubMed, MEDLINE, Ovid, and Embase to identify all English literature accounts of intravenous Ang II in humans for the treatment of shock (systolic blood pressure [SBP] ≤ 90 mmHg or a mean arterial pressure [MAP] ≤ 65 mmHg), and hand-searched the references of extracted papers for further studies meeting inclusion criteria...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29279637/an-interventional-quality-improvement-study-to-assess-the-compliance-to-cardiopulmonary-resuscitation-documentation-in-an-indian-teaching-hospital
#16
Viraj Nevrekar, Prasan Kumar Panda, Naveet Wig, R M Pandey, Praveen Agarwal, Ashutosh Biswas
Background: Cardiopulmonary resuscitation (CPR) should be performed as per the international guidelines; however, compliance to these guidelines is difficult to assess. This study was conducted to determine the compliance to American Heart Association (2010) guideline on CPR documentation by among resident physicians before and after resident training (two arms). Methods: This pre-postinterventional quality improvement study was conducted in a referral center, North India...
November 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29279413/association-between-diastolic-blood-pressure-during-pediatric-in-hospital-cardiopulmonary-resuscitation-and-survival
#17
Robert A Berg, Robert M Sutton, Ron W Reeder, John T Berger, Christopher J Newth, Joseph A Carcillo, Patrick S McQuillen, Kathleen L Meert, Andrew R Yates, Rick E Harrison, Frank W Moler, Murray M Pollack, Todd C Carpenter, David L Wessel, Tammara L Jenkins, Daniel A Notterman, Richard Holubkov, Robert F Tamburro, J Michael Dean, Vinay M Nadkarni
Background -Based on laboratory cardiopulmonary resuscitation (CPR) investigations and limited adult data demonstrating that survival depends on attaining adequate arterial diastolic blood pressure (DBP) during CPR, American Heart Association recommends using BP to guide pediatric CPR. However, evidence-based BP targets during pediatric CPR remain an important knowledge gap for CPR guidelines. Methods -All children ≥37 weeks gestation and <19 years old in Collaborative Pediatric Critical Care Research Network intensive care units with chest compressions for ≥1 minute and invasive arterial blood pressure monitoring prior to and during CPR between July 1, 2013 and June 31, 2016 were included...
December 26, 2017: Circulation
https://www.readbyqxmd.com/read/29275998/does-early-coronary-angiography-improve-survival-after-out-of-hospital-cardiac-arrest-a-systematic-review-with-meta-analysis
#18
REVIEW
Michelle Welsford, Matthias Bossard, Colleen Shortt, Jodie Pritchard, Madhu K Natarajan, Emilie P Belley-Côté
BACKGROUND: In patients with out-of-hospital cardiac arrest who achieve return of spontaneous circulation, coronary angiography (CAG) might improve outcomes. We conducted a systematic review and meta-analysis to elucidate the benefit and optimal timing of early CAG in comatose out-of-hospital cardiac arrest patients with return of spontaneous circulation. METHODS: We searched MEDLINE, EMBASE, and Cochrane from 1990 to May 2017. Studies reporting survival and/or neurological survival in early (< 24-hour) vs late/no CAG were selected...
September 18, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29273461/evolution-of-survival-in-cardiac-arrest-with-age-in-elderly-patients-is-resuscitation-a-dead-end
#19
Nicolas Segal, Christophe di Pompéo, Joséphine Escutnaire, Eric Wiel, Cyrielle Dumont, Laurent Castra, Karim Tazarourte, Carlos El Khoury, Pierre-Yves Gueugniaud, Hervé Hubert
BACKGROUND: Even if age is not considered the key prognostic factor for survival in cardiac arrest (CA), some studies question whether cardiopulmonary resuscitation (CPR) in the elderly could be futile. OBJECTIVE: The aim of this study was to describe differences in out-of-hospital CA survival rates according to age stratification based on the French National CA registry (RéAC). The second objective was to analyze the differences in resuscitation interventions according to age...
December 19, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29261569/the-cumulative-partial-pressure-of-arterial-oxygen-is-associated-with-neurological-outcomes-after-cardiac-arrest-treated-with-targeted-temperature-management
#20
Chun Song Youn, Kyu Nam Park, Soo Hyun Kim, Byung Kook Lee, Sang Hoon Oh, Kyung Woon Jeung, Seung Pill Choi
OBJECTIVE: Hyperoxia could lead to a worse outcome after cardiac arrest. The aim of this study was to investigate the relationship between the cumulative partial pressure of arterial oxygen (PaO2) and neurological outcomes after cardiac arrest treated with targeted temperature management. DESIGN: Retrospective analysis of a prospective cohort. SETTING: An academic tertiary care hospital. PATIENTS: A total of 187 consecutive patients treated with targeted temperature management after cardiac arrest...
December 19, 2017: Critical Care Medicine
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