Di-Yang Sun, Wen-Bin Wu, Jian-Jin Wu, Yu Shi, Jia-Jun Xu, Shen-Xi Ouyang, Chen Chi, Yi Shi, Qing-Xin Ji, Jin-Hao Miao, Jiang-Tao Fu, Jie Tong, Ping-Ping Zhang, Jia-Bao Zhang, Zhi-Yong Li, Le-Feng Qu, Fu-Ming Shen, Dong-Jie Li, Pei Wang
Senescence of vascular smooth muscle cells (VSMCs) contributes to aging-related cardiovascular diseases by promoting arterial remodelling and stiffness. Ferroptosis is a novel type of regulated cell death associated with lipid oxidation. Here, we show that pro-ferroptosis signaling drives VSMCs senescence to accelerate vascular NAD+ loss, remodelling and aging. Pro-ferroptotic signaling is triggered in senescent VSMCs and arteries of aged mice. Furthermore, the activation of pro-ferroptotic signaling in VSMCs not only induces NAD+ loss and senescence but also promotes the release of a pro-senescent secretome...
February 16, 2024: Nature Communications