keyword
https://read.qxmd.com/read/38438692/patient-specific-haemodynamic-analysis-of-virtual-grafting-strategies-in-type-b-aortic-dissection-impact-of-compliance-mismatch
#21
JOURNAL ARTICLE
Louis Girardin, Catriona Stokes, Myat Soe Thet, Aung Ye Oo, Stavroula Balabani, Vanessa Díaz-Zuccarini
INTRODUCTION: Compliance mismatch between the aortic wall and Dacron Grafts is a clinical problem concerning aortic haemodynamics and morphological degeneration. The aortic stiffness introduced by grafts can lead to an increased left ventricular (LV) afterload. This study quantifies the impact of compliance mismatch by virtually testing different Type-B aortic dissection (TBAD) surgical grafting strategies in patient-specific, compliant computational fluid dynamics (CFD) simulations. MATERIALS AND METHODS: A post-operative case of TBAD was segmented from computed tomography angiography data...
March 4, 2024: Cardiovascular Engineering and Technology
https://read.qxmd.com/read/38431129/endothelial-cell-serum-and-glucocorticoid-regulated-kinase-1-sgk1-mediates-vascular-stiffening
#22
JOURNAL ARTICLE
Liping Zhang, Zhe Sun, Yan Yang, Austin Mack, Mackenna Rodgers, Annayya Aroor, Guanghong Jia, James R Sowers, Michael A Hill
BACKGROUND: Excessive dietary salt intake increases vascular stiffness in humans, especially in salt-sensitive populations. While we recently suggested that the endothelial sodium channel (EnNaC) contributes to salt-sensitivity related endothelial cell (EC) and arterial stiffening, mechanistic understanding remains incomplete. This study therefore aimed to explore the role of EC-serum and glucocorticoid regulated kinase 1 (SGK1), as a reported regulator of sodium channels, in EC and arterial stiffening...
February 29, 2024: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/38426347/mineralocorticoid-receptors-in-vascular-smooth-muscle-blood-pressure-and-beyond
#23
REVIEW
Nicholas D Camarda, Jaime Ibarrola, Lauren A Biwer, Iris Z Jaffe
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR from smooth muscle cells (SMCs) in mice has elucidated contributions of SMC-MR to cardiovascular function and disease, independent of the kidney. This review summarizes the latest understanding of the molecular mechanisms by which SMC-MR contributes to (1) regulation of vasomotor function and blood pressure to contribute to systemic and pulmonary hypertension; (2) vascular remodeling in response to hypertension, vascular injury, obesity, and aging, and the impact on vascular calcification; and (3) cardiovascular pathologies including aortic aneurysm, heart valve dysfunction, and heart failure...
March 1, 2024: Hypertension
https://read.qxmd.com/read/38425812/efficacy-and-safety-of-a-minimalistic-balloon-aortic-valvuloplasty-strategy-in-a-centre-without-heart-surgery
#24
JOURNAL ARTICLE
Matteo Bruno, Gianmarco Iannopollo, Laura Sofia Cardelli, Alessandro Capecchi, Valerio Lanzilotti, Roberto Verardi, Chiara Pedone, Giampiero Nobile, Gianni Casella
BACKGROUND: Balloon aortic valvuloplasty (BAV) is a palliative tool for patients with symptomatic severe aortic stenosis (AS) at prohibitive risk for surgery or as a bridge to surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). BAV is traditionally performed in hospitals with onsite cardiac surgery due to its potential complications. AIMS: The aim of this study was to evaluate the safety of BAV procedures performed by trained high-volume operators in a centre without onsite surgery and to assess the effect of a minimalistic approach to reduce periprocedural complications...
February 2024: AsiaIntervention
https://read.qxmd.com/read/38420559/type-iii-aortic-arch-angulation-increases-aortic-stiffness-analysis-from-an-ex%C3%A2-vivo-porcine-model
#25
JOURNAL ARTICLE
Tim J Mandigers, Ariel F Pascaner, Michele Conti, Martina Schembri, Sonja Jelic, Alessandra Favilli, Daniele Bissacco, Maurizio Domanin, Joost A van Herwaarden, Ferdinando Auricchio, Santi Trimarchi
OBJECTIVE: The relationship among increased aortic arch angulation, aortic flow dynamics, and vessel wall stiffness remains unclear. This experimental ex vivo study investigated how increased aortic arch angulation affects aortic stiffness and stent-graft induced aortic stiffening, assessed by pulse wave velocity (PWV). METHODS: Porcine thoracic aortas were connected to a circulatory mock loop in a Type I and Type III aortic arch configuration. Baseline characteristics and blood pressures were measured...
February 2024: JTCVS open
https://read.qxmd.com/read/38418756/functional-deterioration-of-vascular-mitochondrial-and-glycolytic-capacity-in-the-aortic-rings-of-aged-mice
#26
JOURNAL ARTICLE
Agnieszka Karaś, Anna Bar, Kanchana Pandian, Agnieszka Jasztal, Zuzanna Kuryłowicz, Barbara Kutryb-Zając, Elżbieta Buczek, Stefano Rocchetti, Tasnim Mohaissen, Agata Jędrzejewska, Amy C Harms, Patrycja Kaczara, Stefan Chłopicki
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy metabolism. The aim of this study was to establish a Seahorse XFe96 Analyzer-based methodology for the reliable, functional assessment of mitochondrial respiration and glycolysis in single murine aortic rings and to validate this functional assay by characterising alterations in vascular energy metabolism in aged mice. Healthy young and old C57BL/6 mice were used for the analyses...
February 28, 2024: GeroScience
https://read.qxmd.com/read/38415056/metabolic-clues-to-aging-exploring-the-role-of-circulating-metabolites-in-frailty-sarcopenia-and-vascular-aging-related-traits-and-diseases
#27
JOURNAL ARTICLE
Zonghao Qian, Yuzhen Huang, Yucong Zhang, Ni Yang, Ziwei Fang, Cuntai Zhang, Le Zhang
Background: Physical weakness and cardiovascular risk increase significantly with age, but the underlying biological mechanisms remain largely unknown. This study aims to reveal the causal effect of circulating metabolites on frailty, sarcopenia and vascular aging related traits and diseases through a two-sample Mendelian Randomization (MR) analysis. Methods: Exposures were 486 metabolites analyzed in a genome-wide association study (GWAS), while outcomes included frailty, sarcopenia, arterial stiffness, atherosclerosis, peripheral vascular disease (PAD) and aortic aneurysm...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38402283/diabetes-mellitus-modifies-the-association-between-chronic-kidney-disease-mineral-and-bone-disorder-biomarkers-and-aortic-stiffness-in-peritoneal-dialysis-patients
#28
JOURNAL ARTICLE
Hsiang-Jung Huang, Bang-Gee Hsu, Chih-Hsien Wang, Jen-Pi Tsai, Yi-Hsin Chen, Szu-Chun Hung, Yu-Li Lin
This study aimed to investigate the relationship of four chronic kidney disease-mineral and bone disorder (CKD-MBD) biomarkers, including intact parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), soluble klotho, and fetuin-A, with aortic stiffness in peritoneal dialysis (PD) patients, comparing those with and without diabetes mellitus (DM). A total of 213 patients (mean age 58 ± 14 years; 81 (38.0%) patients with DM) were enrolled. Their aortic pulse wave velocity (PWV) was measured using pressure applanation tonometry, while serum intact PTH, FGF23, α-klotho, and fetuin-A levels were measured using enzyme-linked immunosorbent assay...
February 24, 2024: Scientific Reports
https://read.qxmd.com/read/38400621/vascular-protein-disulfide-isomerase-a1-mediates-endothelial-dysfunction-induced-by-angiotensin-ii-in-mice
#29
JOURNAL ARTICLE
Agnieszka Kij, Anna Bar, Izabela Czyzynska-Cichon, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Elzbieta Buczek, Anna Kurpinska, Joanna Suraj-Prazmowska, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Andreas Daiber, Matthias Oelze, Maria Walczak, Stefan Chlopicki
AIM: Protein disulfide isomerases (PDIs) are involved in platelet aggregation and intravascular thrombosis, but their role in regulating endothelial function is unclear. Here, we characterized the involvement of vascular PDIA1 in angiotensin II (Ang II)-induced endothelial dysfunction in mice. METHODS: Endothelial dysfunction was induced in C57BL/6JCmd male mice via Ang II subcutaneous infusion, and PDIA1 was inhibited with bepristat. Endothelial function was assessed in vivo with magnetic resonance imaging and ex vivo with a myography, while arterial stiffness was measured as pulse wave velocity...
February 23, 2024: Acta Physiologica
https://read.qxmd.com/read/38395029/cardiac-and-perivascular-myofibroblasts-matrifibrocytes-and-immune-fibrocytes-in-hypertension-commonalities-and-differences-with-myocardial-infarction-and-other-cardiovascular-diseases
#30
JOURNAL ARTICLE
Keiichi Torimoto, Katherine Elliott, Yuki Nakayama, Hiromi Yanagisawa, Satoru Eguchi
Hypertension is a major cause of cardiovascular diseases such as myocardial infarction and stroke. Cardiovascular fibrosis occurs with hypertension and contributes to vascular resistance, aortic stiffness, and cardiac hypertrophy. However, the molecular mechanisms leading to the fibroblast activation in hypertension remain largely unknown. There are two types of fibrosis: replacement fibrosis and reactive fibrosis. Replacement fibrosis occurs in response to the loss of viable tissue to form a scar. Reactive fibrosis occurs in response to increase in mechanical and neurohormonal stress...
February 23, 2024: Cardiovascular Research
https://read.qxmd.com/read/38394648/effects-of-pre-exercise-intake-of-plant-and-animal-based-foods-on-arterial-function-and-aerobic-exercise-capacity-in-healthy-young-men-a-randomized-cross-over-trial
#31
JOURNAL ARTICLE
Maho Ishiwata, Urara Hata, Yuto Hashimoto, Takanobu Okamoto
The purpose of this study was to examine the effects of plant- vs. animal-based food intake before exercise on arterial function and subsequent aerobic exercise capacity. Eleven healthy adult males (mean age, 22.6 ± 1.8 years) participated in this study. A plant- or animal-based randomized meal type crossover comparison was conducted on separate days with a uniform protein, fat, and carbohydrate balance. Both carotid-femoral pulse wave velocity (cfPWV), femoral-ankle pulse wave velocity (faPWV), and brachial artery flow-mediated dilatation (FMD) were measured as indexes of aortic and peripheral arterial stiffness and vascular endothelial function, respectively, before and at 120 min after the meal...
February 23, 2024: Applied Physiology Nutrition and Metabolism
https://read.qxmd.com/read/38391866/the-role-of-carotid-femoral-pulse-wave-velocity-in-a-metabolic-syndrome-patient-with-sudden-cardiac-arrest-a-case-report
#32
Hau Kim Choy, Paweł Bogdański, Damian Skrypnik
INTRODUCTION: Carotid-femoral pulse wave velocity reflecting aortic stiffness could be used as an independent predictor of future cardiovascular events for an individual with metabolic syndrome. However, the routine use of carotid-femoral pulse wave velocity is suboptimized in clinical practice. We report a case of metabolic syndrome with increased carotid-femoral pulse wave velocity and subsequently developed myocardial infarction and sudden cardiac arrest. CASE PRESENTATION: A Polish man of an age between 40 and 50 years previously diagnosed with metabolic syndrome with essential hypertension, obesity, dyslipidaemia, and impaired glucose level...
February 18, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38374913/arterial-stiffness-and-aortic-aneurysmal-disease-a-narrative-review
#33
REVIEW
Konstantinos G Moulakakis, Christos F Pitros, Ioannis T Theodosopoulos, Spyridon N Mylonas, John D Kakisis, Christos Manopoulos, Nikolaos P E Kadoglou
It has been documented that large-artery stiffness is independently associated with increased cardiovascular risk and may potentially lead to heart and kidney failure and cerebrovascular disease. A systematic review of studies investigating changes in arterial stiffness in patients undergoing endovascular repair of aortic disease was conducted. In addition, a review of the available literature was performed, analyzing findings from studies using the cardio-ankle vascular index (CAVI) as a marker of arterial stiffness...
2024: Vascular Health and Risk Management
https://read.qxmd.com/read/38374519/biomechanical-remodeling-of-aortic-valve-interstitial-cells-during-calcified-lesion-formation-in-vitro
#34
JOURNAL ARTICLE
Justine Yushiuan Shih, Terence Gee, Gaetano Scuderi, Jonathan Butcher
Healthy aortic heart valves are essential to the regulation of unidirectional blood flow. Calcific aortic valve disease (CAVD) is an actively progressive disease that involves the disorganization of valve cells and accumulation of calcium deposits on the aortic valve leaflets. CAVD involves disruption of cell environment homeostasis that prior cell culture models have found difficult to portray and model. As it is still poorly understood how tissue stiffening associates with lesion formation, here, we implement a novel 3D culture platform to characterize the relationship between mechanical stress and tissue remodeling and analyze how the application of pro-osteogenic stimulation dysregulates the native ability of valve cells to organize its matrix...
February 19, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38372858/echogenomics-echocardiography-in-heritable-aortopathies
#35
REVIEW
Lyndsey Hunter-Adamson, Seda Tierney
PURPOSE OF REVIEW: The aim of this article is to review the current echocardiographic considerations in the diagnosis and monitoring of patients with inherited aortopathies. RECENT FINDINGS: Aortic dilation is a key feature in heritable aortopathies, and dissection is a leading cause of morbidity and mortality. New genetic and histopathologic findings are helpful in better understanding these conditions. Non-invasive imaging modalities, including echocardiogram, computerized tomography, and magnetic resonance imaging, are essential in monitoring these patients, as well as providing new prognostic factors of arterial stiffness that may help with risk stratification in the future...
February 19, 2024: Current Cardiology Reports
https://read.qxmd.com/read/38369194/evaluation-of-cardiovascular-risk-factors-in-children-aged-6-16-years-and-their-evolution-at-early-adulthood-in-a-10-year-follow-up-study
#36
JOURNAL ARTICLE
Eleni Ntretsiou, Dimitris Benas, Paraskevi Trivilou, George Pavlidis, Ignatios Ikonomidis, Achilleas Attilakos, Efstathios Iliodromitis, Helen Triantafyllidi
AIM: Obesity and arterial hypertension (AH) in children represent well recognized risk factors for cardiovascular (CV) events during adult life. We investigated any changes regarding several CV risk (CVR) factors of children after a 10-year follow-up period. METHODS: A cohort of 143 healthy children, elementary/high-school students, 6-16 years old was initially evaluated in 2010-2011 regarding CVR factors [obesity, blood pressure (BP), aortic stiffness (PWV), lipid profile] plus food habits/sports activity...
February 16, 2024: Hellenic Journal of Cardiology: HJC
https://read.qxmd.com/read/38365899/pro-ferroptotic-signaling-promotes-arterial-aging-via-vascular-smooth-muscle-cell-senescence
#37
JOURNAL ARTICLE
Di-Yang Sun, Wen-Bin Wu, Jian-Jin Wu, Yu Shi, Jia-Jun Xu, Shen-Xi Ouyang, Chen Chi, Yi Shi, Qing-Xin Ji, Jin-Hao Miao, Jiang-Tao Fu, Jie Tong, Ping-Ping Zhang, Jia-Bao Zhang, Zhi-Yong Li, Le-Feng Qu, Fu-Ming Shen, Dong-Jie Li, Pei Wang
Senescence of vascular smooth muscle cells (VSMCs) contributes to aging-related cardiovascular diseases by promoting arterial remodelling and stiffness. Ferroptosis is a novel type of regulated cell death associated with lipid oxidation. Here, we show that pro-ferroptosis signaling drives VSMCs senescence to accelerate vascular NAD+ loss, remodelling and aging. Pro-ferroptotic signaling is triggered in senescent VSMCs and arteries of aged mice. Furthermore, the activation of pro-ferroptotic signaling in VSMCs not only induces NAD+ loss and senescence but also promotes the release of a pro-senescent secretome...
February 16, 2024: Nature Communications
https://read.qxmd.com/read/38353371/exploring-cardiovascular-implications-of-juvenile-dermatomyositis-insights-from-aortic-stiffness-analysis-and-3d-echocardiography
#38
JOURNAL ARTICLE
Reyhan Dedeoglu, Nujin Uluğ Murt, Aybuke Gunalp, Funda Oztunc, Savas Dedeoglu, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
OBJECTIVE: Our goal was to use three dimensional (3D) strain analysis to evaluate myocardial function and ascending aorta elasticity changes in juvenile dermatomyositis (JDM). METHODS: Between 2019 and 2021, 23 JDM patients and 20 healthy volunteers participated. Both groups underwent 2D and 3D strain analysis, assessing aortic stiffness using aortic distensibility, stiffness index, strain, and elastic modulus. RESULTS: JDM patients had a median age of 13...
February 2024: Echocardiography
https://read.qxmd.com/read/38348796/angiotensin-receptor-neprilysin-inhibition-sacubitril-valsartan-reduces-structural-arterial-stiffness-in-middle-aged-mice
#39
JOURNAL ARTICLE
Isabel N Schellinger, Angelika Dannert, Annet Hoffmann, Giriprakash Chodisetti, Karin Mattern, Anne Petzold, Nora Klöting, Andreas Schuster, Markus U Wagenhäuser, Fabian Emrich, Michael Stumvoll, Gerd Hasenfuß, Uwe Raaz
BACKGROUND: Increasing arterial stiffness is a prominent feature of the aging cardiovascular system. Arterial stiffening leads to fundamental alterations in central hemodynamics with widespread detrimental implications for organ function resulting in significant morbidity and death, and specific therapies to address the underlying age-related structural arterial remodeling remain elusive. The present study investigates the potential of the recently clinically available dual angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan (LCZ696) to counteract age-related arterial fibrotic remodeling and stiffening in 1-year-old mice...
February 13, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38345599/vascular-remodeling-during-late-gestation-pregnancy-an-in-vitro-assessment-of-the-murine-ascending-thoracic-aorta
#40
JOURNAL ARTICLE
Ana I Vargas, Samar A Tarraf, Turner Jennings, Chiara Bellini, Rouzbeh Amini
Maternal mortality due to cardiovascular disease is a rising concern in the U.S. Pregnancy triggers changes in the circulatory system, potentially influencing the structure of the central vasculature. Evidence suggests a link between a woman's pregnancy history and future cardiovascular health, but our understanding remains limited. To fill this gap, we examined the passive mechanics of the murine ascending thoracic aorta during late gestation. By performing biaxial mechanical testing on the ascending aorta, we were able to characterize the mechanical properties of both control and late-gestation tissues...
February 12, 2024: Journal of Biomechanical Engineering
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