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Aortic stiffness

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https://www.readbyqxmd.com/read/28637199/first-ex-vivo-and-preliminary-sheep-model-results-of-the-new-tribio-aortic-valve-bioprosthesis-in-small-aortic-annuli
#1
Sina Stock, Hans-Hinrich Sievers, Doreen Richardt, Michael Scharfschwerdt
OBJECTIVES: : Small aortic annuli are challenging in aortic valve replacement. Prosthesis-patient mismatch, accompanied by high transvalvular gradients and small orifice area, is an often faced problem impairing postoperative outcome. The new TRIBIO bioprosthesis aims to enable enhanced haemodynamics, being increasingly important with decreasing annular size. This study compares ex vivo hydrodynamics of TRIBIO with 2 established bioprostheses in small annuli at different stroke volumes, simulating 'rest' and 'exercise', and evaluates haemodynamics of TRIBIO in a sheep model...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28623932/impact-of-glycemic-control-on-aortic-stiffness-left-ventricular-mass-and-diastolic-longitudinal-function-in-type-2-diabetes-mellitus
#2
Michaela Kozakova, Carmela Morizzo, Alan G Fraser, Carlo Palombo
BACKGROUND: Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of diastolic function. The present study investigated the inter-relationships between glycemic control, early diastolic and systolic longitudinal velocity of mitral annulus, LV mass and aortic stiffness in T2DM patients free of cardiovascular disease and with preserved LV ejection fraction, and compared them with those observed in healthy volunteers of similar age and sex distribution...
June 17, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28623503/investigating-the-suitability-of-carbon-nanotube-reinforced-polymer-in-transcatheter-valve-applications
#3
Monica M Rozeik, David J Wheatley, Terence Gourlay
The current delivery size of transcatheter aortic valves, limited by the thickness of their pericardial leaflets, correlates with a high prevalence of major vascular complications. Polyurethane valves can be developed to a fraction of the thickness of pericardial valves through the addition of carbon nanotubes to reinforce their leaflets. This study investigates the suitability of a novel carbon nanotube reinforced leaflet to reduce the delivery profile of transcatheter aortic valves. Carbon nanotube polyurethane composites were developed with thicknesses of 50 μm and their mechanical properties were determined in relation to various environmental effects...
June 16, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28616854/ventricular-arterial-coupling-in-centenarians-without-cardiovascular-diseases
#4
Andrea Sonaglioni, Massimo Baravelli, Michele Lombardo, Carmen Sommese, Claudio Anzà, Jonathan A Kirk, Luigi Padeletti
BACKGROUND: Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance. METHODS: Thirty-three centenarians (100.6 ± 1.2 years, range 99-105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area...
June 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28614093/central-diastolic-pressure-decay-mediates-the-relationship-between-aortic-stiffness-and-myocardial-viability-potential-implications-for-aortosclerosis-induced-myocardial-ischemia
#5
Junichiro Hashimoto, Sadayoshi Ito
OBJECTIVE: Stiffening of the aorta often precedes coronary events, but little is known about the aetiological mechanism. We hypothesized that the predisposition to myocardial ischemia could be attributable to aortosclerosis-induced alterations in the central haemodynamics during diastole. METHODS: Using noninvasive tonometry and ultrasonography, we investigated the arterial pressure pulse waveforms, pulse wave velocities (PWVs) and compliance in 222 patients with hypertension...
June 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28612909/implantation-of-stents-for-postsurgical-recoarctation-of-the-aorta-in-adolescents-and-adults
#6
Sylwia Sulik-Gajda, Roland Fiszer, Jacek Białkowski, Beata Chodór, Szymon Pawlak, Małgorzata Szkutnik
BACKGROUND: Results of stent implantation (SI) of postsurgical recoarctation of the aorta (ReCoA) are not frequently published. AIM: This study sought to retrospectively evaluate results of SI in ReCoA in older children and adults. METHODS: Twenty-eight SI were performed on 26 ReCoA patients with a median age of 23(10-65) years. Dependent upon availability, the following stents were applied -Palmaz, Cheatham Platinum (CP), Andrastents XL/XXL(AS), Covered CP (CVCP) stents and selfexpanding stents (Smart)...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28607132/impaired-muscle-oxygenation-and-elevated-exercise-blood-pressure-in-hypertensive-patients-links-with-vascular-stiffness
#7
Konstantina Dipla, Areti Triantafyllou, Nikolaos Koletsos, Stavros Papadopoulos, Vasileios Sachpekidis, Ioannis S Vrabas, Eugenia Gkaliagkousi, Andreas Zafeiridis, Stella Douma
This study examined in vivo (1) skeletal muscle oxygenation and microvascular function, at rest and during handgrip exercise, and (2) their association with macrovascular function and exercise blood pressure (BP), in newly diagnosed, never-treated patients with hypertension and normotensive individuals. Ninety-one individuals (51 hypertensives and 40 normotensives) underwent office and 24-hour ambulatory BP, arterial stiffness, and central aortic BP assessment, followed by a 5-minute arterial occlusion and a 3-minute submaximal handgrip exercise...
June 12, 2017: Hypertension
https://www.readbyqxmd.com/read/28601673/histopathological-and-biomechanical-properties-of-the-aortic-wall-in-2-patients-with-chronic-type-a-aortic-dissection
#8
Alexander Emmott, Ismaïl El-Hamamsy, Richard L Leask
Type A aortic dissection is an acute condition that requires urgent surgical intervention. However, in a subset of patients, aortic dissections go undiagnosed and become chronic, thereby allowing the dissected wall to undergo a distinct remodeling process from that of the surrounding intact wall. Here, we observe the biomechanical and histological changes in the aortic wall of two patients with chronic Type A aortic dissection. Partial or complete disruption of the elastic structure of the medial layer was observed in the dissected wall of both patients; however, aortic stiffness in the region of dissection covaried with a change in collagen content...
May 30, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28601234/comparison-of-echocardiographic-findings-in-patients-with-nonfunctioning-adrenal-incidentalomas
#9
Narin Nasıroglu Imga, Ozgul Ucar Elalmıs, Mazhar Muslum Tuna, Bercem Aycıcek Dogan, Deniz Sahın, Tugba Gursoy, Yavuz Yalcın, Dilek Berker, Serdar Guler
Adrenal incidentalomas (AIs) are usually discovered incidentally after imaging unrelated to adrenal glands. We aimed to evaluate standard risk factors for systemic atherosclerosis and echocardiographic changes in patients with nonfunctioning AIs and compare them with normal subjects. We evaluated 70 patients diagnosed with AIs and 51 healthy controls. Mean levels were determined for HbA1c, LDL, uric acid, fasting plasma insulin, HOMA, and neutrophil-to-lymphocyte ratio (NLR), and these values were found to be significantly higher in the patients than the controls...
June 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28597335/effect-of-endoskeleton-stent-graft-design-on-pulse-wave-velocity-in-patients-undergoing-endovascular-repair-of-the-aortic-arch
#10
Daijiro Hori, Kei Akiyoshi, Koichi Yuri, Satoshi Nishi, Takao Nonaka, Takahiro Yamamoto, Yusuke Imamura, Harunobu Matsumoto, Naoyuki Kimura, Atsushi Yamaguchi
PURPOSE: Pulse wave velocity (PWV), which measures vascular stiffness, is a powerful predictor of cardiovascular event. Treatment of aneurysms with endovascular prosthesis has been reported to increase PWV. The purpose of this study was to evaluate whether an endoskeleton stent graft design has less effect on PWV than the exoskeleton stent graft design. METHODS: Between July 2008 and September 2016, 74 patients underwent endovascular treatment of aortic arch aneurysm in our institution...
June 8, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28597231/development-of-an-in-vitro-piv-setup-for-preliminary-investigation-of-the-effects-of-aortic-compliance-on-flow-patterns-and-hemodynamics
#11
Martin Büsen, Christian Arenz, Michael Neidlin, Sam Liao, Thomas Schmitz-Rode, Ulrich Steinseifer, Simon J Sonntag
The aorta with its compliance plays a major role in hemodynamics as it saves a portion of ejected blood during systole which is then released in diastole. The aortic compliance decreases with increasing age, which is related to several cardiovascular imparities and diseases. Changes in flow patterns and pressure curves, due to varying aortic compliance, are difficult to investigate in vivo. As a result, the aim of the present work was to develop an in vitro setup enabling standardized investigations on the effect of compliance changes on flow patterns and pressure curves...
June 8, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28594710/twenty-four-hour-central-blood-pressure-is-not-better-associated-with-hypertensive-target-organ-damage-than-24-h-peripheral-blood-pressure
#12
Alejandro de la Sierra, Julia Pareja, Patricia Fernández-Llama, Pedro Armario, Sergi Yun, Eva Acosta, Francesca Calero, Susana Vázquez, Pedro Blanch, Cristina Sierra, Anna Oliveras
BACKGROUND AND AIM: Central blood pressure (BP) is increasingly considered as a better estimator of hypertension associated risks. We aimed to evaluate the association of 24-h central BP, in comparison with 24-h peripheral BP, with the presence of target organ damage (TOD). METHODS: Cross-sectional study of 208 hypertensive patients, aged 57 ± 12 years, 34% women. Office (mean of 4 measurements) and 24-h central and peripheral BP were measured by the oscillometric Mobil-O-Graph device...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28594337/-op-1c-08-hemodynamic-parameters-in-hypertensive-diabetic-patients
#13
A Yannoutsos, M Ahouah, C Dreyfuss Tubiana, J Topouchian, C Touboul, M Safar, J Blacher
OBJECTIVE: Despite adequate glycemic and blood pressure (BP) control, diabetic hypertensives remain at increased cardiovascular (CV) risk. Aortic stiffness and pulse pressure (PP) amplification may provide complementary information to correct CV risk. We aim to determine whether these hemodynamic parameters are interrelated or not and to explore the factors related to pressure pulsatility.(Figure is included in full-text article.)DESIGN AND METHOD:: A cross-sectional study was conducted in 351 patients, involving controls, hypertensives without diabetes and diabetic patients with or without hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/28587127/gender-differences-of-arterial-stiffness-and-arterial-age-in-smokers
#14
Ioana Mozos, Jean Paul Maidana, Dana Stoian, Milan Stehlik
The present study aimed to find gender differences for arterial stiffness and arterial aging in smokers. A total of 147 smokers (71 male and 76 female, matched for age) were explored using an Arteriograph in a cross-sectional survey. Pulse wave velocity (PWV), arterial age (AA), brachial and aortic augmentation index (AixBrach, AixAo), and blood pressure variables were assessed. Data about smoking intensity, such as the number of cigarettes smoked daily, smoking period, and smoking pack years (SPY) were used...
May 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28579791/color-m-mode-echocardiography-derived-propagation-velocity-of-descending-aorta-decreases-with-aging
#15
Mehmet Yaman, Uğur Arslan, Adil Bayramoğlu, Osman Bektaş, Ahmet Karataş
BACKGROUND: Arterial stiffness (AS) can be determined by some noninvasive tests such as pulse wave velocity (PWV). Atherosclerosis is also detectable by some ultrasonographic techniques such as color M-mode-derived propagation velocity measured along the origin of the descending aorta (AVP). AIM: The aim of the study was to find out a possible relationship between atherosclerosis and AVP and whether AVP can be used as a parameter of AS. MATERIALS AND METHODS: The study group was composed of 134 people from routine screening examination who were ≥40 years old, completely healthy, and without any known disease and use of any drug...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28576700/tumoral-calcinosis-diffuse-multifocal-form-in-hemodialysis-patients-two-case-reports
#16
D Ibrahim Montasser, J Issouani, Mohamed Hassani, D Kabbaj
Orthopedic surgeons are often consulted for diagnosis of MASS (mitral valve prolapse, aortic enlargement, skin and skeletal findings) syndrome, imaging showing periarticular calcification, or joint stiffness. Such presentations in a dialyzed patient should suggest tumoral calcinosis, which is a rare complication of dialysis, often diagnosed wrongly or late. It is often associated with calcium phosphate balance disorder, in which treatment is difficult and must take account of known contributing factors: severe hyperparathyroidism, increased phosphocalcic product, therapeutic calcium and vitamin D overload, and bone turnover slowed for varying reasons...
May 30, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28575172/longitudinal-changes-in-excess-pressure-independently-predict-declining-renal-function-among-healthy-individuals-a-pilot-study
#17
Rachel E D Climie, Dean S Picone, James E Sharman
BACKGROUND: Aortic reservoir function independently predicts end-organ damage in cross-sectional analyses. However, longitudinal associations are more important regarding causation, but this has never been examined at rest or in response to light-moderate intensity exercise. The aim of this study was to determine the association between the change in aortic reservoir characteristics, in particular excess pressure integral (Pexcess) at rest and in response to exercise and the change in kidney function among healthy individuals followed over time...
May 30, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28572599/comparisons-of-microvascular-and-macrovascular-changes-in-aldosteronism-related-hypertension-and-essential-hypertension
#18
Monica Varano, Pierluigi Iacono, Massimiliano M Tedeschi, Claudio Letizia, Mario Curione, Claudio Savoriti, Erika Baiocco, Laura Zinnamosca, Cristiano Marinelli, Barbara Boccassini, Mariacristina Parravano
Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the retinal artery diameter (RAD), retinal vein diameters (RVD) and arteriole-to-venule ratio (AVR) of the vessels coming off the optic disc...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28569670/construction-of-cell-containing-anisotropic-three-dimensional-collagen-fibril-scaffolds-using-external-vibration-and-their-influence-on-smooth-muscle-cell-phenotype-modulation
#19
Yao-Nan Zeng, Yi-Lin Kang, Lih-Rou Rau, Fu-Yin Hsu, Shiao-Wen Tsai
Numerous methods have developed for the preparation of guiding channels/tracks to promote the alignment of highly oriented cell types. However, these manufactured methods cannot fabricate interconnected guiding channels within three-dimensional scaffolds. Providing a suitable architectural scaffold for cell attachment could lead cells to more rapidly display a desired phenotype and perform their unique functions. Previously, we developed a simple device composed of a pneumatic membrane that can generate a tunable vibration frequency to apply physical stimulation to fabricate a three-dimensional (3D) aligned collagen fibril matrix with the characteristic D-period structure in one step...
June 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28569376/sex-body-mass-index-and-blood-pressure-are-related-to-aortic-characteristics-in-healthy-young-adults-using-magnetic-resonance-vessel-wall-imaging-the-ambityon-study
#20
Anouk L M Eikendal, Hester M den Ruijter, Cees Haaring, Tobias Saam, Rob J van der Geest, Jos J M Westenberg, Michiel L Bots, Imo E Hoefer, Tim Leiner
OBJECTIVES: More detailed evaluation of atherosclerosis and its key determinants in young individuals is warranted to improve knowledge on the pathophysiology of its development and progression. This study evaluated associations of magnetic resonance imaging (MRI)-derived aortic wall area, wall thickness, and pulse wave velocity (PWV) with cardiovascular risk factors in asymptomatic, young adults. MATERIALS AND METHODS: In 124 adults (age: 25-35 years) from the general population-based Atherosclerosis Monitoring and Biomarker Measurements in the Young study, demography, anthropometry, and blood samples were collected...
May 31, 2017: Magma
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