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Adarsh M Thaker, V Raman Muthusamy, Alireza Sedarat, Rabindra R Watson, Michael L Kochman, Andrew S Ross, Stephen Kim
BACKGROUND AND AIMS: After recent outbreaks of duodenoscope-related infections from multidrug-resistant organisms (MDRO), the United States Food and Drug Administration (FDA) recommended implementing one or more of four enhanced reprocessing measures in addition to updated manual cleaning methods and high-level disinfection (HLD). The implementation of these techniques in endoscopy facilities and provider opinions regarding reprocessing priorities remain unknown. METHODS: Physicians, nurse managers, nurses, and infection control staff at endoscopy units performing ERCP in the United States were surveyed to assess current institutional practices and individual opinions regarding future reprocessing solutions...
April 20, 2018: Gastrointestinal Endoscopy
Yongwei Wang, Yi Pan, Zhaohui Zheng, Xiaobin Ding
Degradable shape memory polymers (SMPs), especially for polyurethane-based SMPs, have shown great potential for biomedical applications. How to reasonably fabricate SMPs with the ideal combination of degradability, shape reconfigurability, and reprocessability is a critical issue and remains a challenge for medical disposable materials. Herein, a shape memory poly(urethane-urea) with synergetic triple dynamic covalent bonds is reported via embedding polycaprolactone unit into poly(urethane-urea) with the hindered urea dynamic bond...
April 20, 2018: Macromolecular Rapid Communications
Nathan P Golightly, Avery Bell, Anna I Bischoff, Parker D Hollingsworth, Stephen R Piccolo
One important use of genome-wide transcriptional profiles is to identify relationships between transcription levels and patient outcomes. These translational insights can guide the development of biomarkers for clinical application. Data from thousands of translational-biomarker studies have been deposited in public repositories, enabling reuse. However, data-reuse efforts require considerable time and expertise because transcriptional data are generated using heterogeneous profiling technologies, preprocessed using diverse normalization procedures, and annotated in non-standard ways...
April 17, 2018: Scientific Data
Xiang-He Kong, Qunyan Wu, Cong-Zhi Wang, Jianhui Lan, Zhi-Fang Chai, Changming Nie, Wei-Qun Shi
Separation of trivalent actinides (An(III)) and lanthanides (Ln(III)) is one of the most important steps in the spent nuclear fuel reprocessing. However, it is very difficult and challenging to separate them due to their similar chemical properties. Recently the pyridylpyrazole ligand (PypzH) has been identified to show good separation ability towards Am(III) over Eu(III). In this work, to explore the Am(III)/Eu(III) separation mechanism of PypzH at the molecular level, the geometrical structures, bonding nature, and thermodynamic behaviors of the Am(III) and Eu(III) complexes with PypzH ligands modified by alkyl chains (Cn-PypzH, n=2, 4, 8) have been systematically investigated using scalar relativistic density functional theory (DFT)...
April 17, 2018: Journal of Physical Chemistry. A
Kenneth Smith, Ibukunoluwa Araoye, Shawn Gilbert, Ken Waites, Bernard Camins, Michael Conklin, Brent Ponce
AIMS: Cannulated surgical instruments may retain biologic debris after routine cleaning and sterilization. Residual debris after cleaning is assumed to be sterile; however, there is no experimental basis for this assumption. The purpose of this study was to determine the sterility of retained biodebris found within cannulated surgical instruments after autoclave sterilization. MATERIALS AND METHODS: Fifteen cannulated drill bits were used to drill pig scapulae to create a plug of bone that was exposed to a mixture of Bacillus cereus, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus for 60, 120, or 180 minutes prior to sterilization...
April 13, 2018: American Journal of Infection Control
Anne-Katharina Deisenhofer, Jaime Delgadillo, Julian A Rubel, Jan R Böhnke, Dirk Zimmermann, Brian Schwartz, Wolfgang Lutz
BACKGROUND: Trauma-focused cognitive behavioral therapy (Tf-CBT) and eye movement desensitization and reprocessing (EMDR) are two highly effective treatment options for posttraumatic stress disorder (PTSD). Yet, on an individual level, PTSD patients vary substantially in treatment response. The aim of the paper is to test the application of a treatment selection method based on a personalized advantage index (PAI). METHOD: The study used clinical data for patients accessing treatment for PTSD in a primary care mental health service in the north of England...
April 16, 2018: Depression and Anxiety
Federico Caobelli, Cristina E Popescu, Riccardo Laudicella, Alessio Comis, Salvatore A Pignata, Roberto Sara, Claudio Rossetti
BACKGROUND: Patients under hemodialysis (HD) have an increased risk of major adverse cardiac events (MACEs). In these patients, myocardial perfusion scintigraphy (MPS) provides useful prognostic information. Left ventricular mechanical dyssynchrony (LVD) has been proven to predict all-cause death in patients under HD. It remains unclear, whether the same prognostic value pertains also to the prediction of MACEs. PATIENTS AND METHODS: Ninety patients under HD (duration range: 2-216 months) with neither history nor symptoms of coronary artery disease at the time of MPS were retrospectively evaluated...
May 2018: Nuclear Medicine Communications
Cori L Ofstead, Otis L Heymann, Mariah R Quick, John E Eiland, Harry P Wetzler
BACKGROUND: Endoscopy-associated infection transmission is frequently linked to inadequate reprocessing. Residual organic material and moisture may foster biofilm development inside endoscopes. This study evaluated the effectiveness of endoscope drying and storage methods and assessed associations between retained moisture and contamination. METHODS: Endoscope reprocessing, drying, and storage practices were assessed at 3 hospitals. Researchers performed visual examinations and tests to detect fluid and contamination on patient-ready endoscopes...
March 30, 2018: American Journal of Infection Control
Miae Kim, Claire L Corkhill, Neil C Hyatt, Jong Heo
Calcium-aluminoborate (CAB) glasses were developed to sequester new waste compositions made of several rare-earth oxides generated from the pyrochemical reprocessing of spent nuclear fuel. Several important wasteform properties such as waste loading, processability and chemical durability were evaluated. The maximum waste loading of the CAB compositions was determined to be ~56.8 wt%. Viscosity and the electrical conductivity of the CAB melt at 1300 °C were 7.817 Pa·s and 0.4603 S/cm, respectively, which satisfies the conditions for commercial cold-crucible induction melting (CCIM) process...
March 28, 2018: Scientific Reports
Romney M Humphries, Shuan Yang, Stephen Kim, Venkatara Raman Muthusamy, Dana Russell, Alisa M Trout, Teresa Zaroda, Quen J Cheng, Grace Aldrovandi, Daniel Zachary Uslan, Peera Hemarajata, Zachary Aaron Rubin
Background: Carbapenem-resistant Klebsiella pneumoniae infections are increasingly prevalent in North American hospitals. We describe an outbreak of carbapenem-resistant K. pneumoniae containing the blaOXA-232 gene transmitted by contaminated duodenoscopes during endoscopic retrograde cholangiopancreatography (ERCP) procedures. Methods: An outbreak investigation was performed when 9 patients with blaOXA-232 carbapenem-resistant K. pneumoniae infections were identified at a tertiary care hospital...
October 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Van-Khoai Do, Masahiko Yamamoto, Shigeo Taguchi, Yuzuru Takamura, Naoki Surugaya, Takehiko Kuno
A sensitive analytical method for determination of total cesium (Cs) in highly active liquid waste (HALW) by using modified liquid electrode plasma optical emission spectrometry (LEP-OES) is developed in this study. The instrument is modified to measure radioactive samples in a glove box. The effects of important factors, including pulsed voltage sequence and nitric acid concentration, on the emission of Cs are investigated. The limit of detection (LOD) and limit of quantification (LOQ) are 0.005 mg/L and 0...
June 1, 2018: Talanta
Debasis Banerjee, Xianyin Chen, Sergey Lobanov, Anna M Plonka, Xiaojun Chan, John Daly, Taejin Kim, Praveen K Thallapally, John Parise
Used nuclear fuel reprocessing represents a unique challenge when dealing with radionuclides such as isotopes of85 Kr and129 I2 due to their volatility and long half-life. Efficient capture of129 I2 (t1/2 = 15.7 ×106 million years) from the nuclear waste stream can help reduce the risk of releasing I2 radionuclide into the environment and/or potential incorporation into the human thyroid. Metal organic frameworks have the reported potential to be I2 adsorbents but the effect of water vapor, generally present in the reprocessing off-gas stream, is rarely taken into account...
March 16, 2018: ACS Applied Materials & Interfaces
Sara Díaz, Zaida Ortega, Mark McCourt, Mark P Kearns, Antonio N Benítez
This study focuses on the mechanical recycling of polymeric waste that is produced in considerable amount from the cable industry. Every year large amounts of cables become waste; wires recycling has traditionally focused on metal recovery, while the polymer cover has just been considered as a residue, being landfilled or incinerated. Nowadays, increasingly restrictive regulations and concern about environment make necessary to reduce landfilling as much as possible. Main novelty of the study is that the material used in the research is a post-consumer material and the entire residual material is used, without a previous purification, in contrast with similar studies...
March 12, 2018: Waste Management
Allison A Feduccia, Michael C Mithoefer
MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying psychological and neurological mechanisms for the robust effects in mitigating PTSD are being investigated in animal models and in studies of healthy volunteers...
March 7, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Hans M Nordahl, Joar Øveraas Halvorsen, Odin Hjemdal, Mimoza Rrusta Ternava, Adrian Wells
TRIALS (2018) 19: 16. HTTPS://DOI.ORG/10.1186/S13063-017-2404-7: In the original publication of this article [1] the SPIRIT figure for the study protocol was not included. In this Correction Article the SPIRIT figure (Fig. 1) is published. The original publication has been updated with the SPIRIT figure.
March 6, 2018: Trials
Wen Cui, Ruyu Wang, Xi Shu, Yu Fan, Yang Liu, Yongdong Jin, Chuanqin Xia, Chao Huang
The interaction between the uranyl cation, (UO2 )2+ , and organic species is of interest due to the potential applications of the resulting compounds with regard to nuclear waste disposal and nuclear fuel reprocessing. The hydrothermal reaction of various uranyl compounds with flexible zwitterionic 1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate) dihydrochloride (Bpmb·2HCl) in deionized water containing drops of H2 SO4 resulted in the formation of a novel two-dimensional uranyl coordination polymer, namely poly[tetraoxido{μ2 -1,1'-[1,4-phenylenebis(methylene)]bis(pyridin-1-ium-4-carboxylate)}di-μ3 -sulfato-diuranium(VI)], [(UO2 )2 (SO4 )2 (C20 H16 N2 O4 )]n , (1)...
March 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
Jeffrey Guina, Cathryn Guina
While post-stroke depression (PSD) is a common sequelae of stroke, many stroke survivors also have expressive aphasia (i.e., the inability to produce spoken or written language), which limits or prevents treating depression with talk psychotherapy. Unlike most psychotherapy modalities, eye movement desensitization and reprocessing (EMDR) does not require extensive verbal communication to therapists, which might make EMDR an ideal treatment modality for aphasic patients with mental health concerns. The authors present the first known case reporting EMDR in aphasia, describing the treatment of a 50-year-old woman with a history of depression following a left middle cerebral artery stroke...
February 1, 2018: Innovations in Clinical Neuroscience
Akikazu Sakudo, Hirotoshi Miyagi, Takaya Horikawa, Risa Yamashiro, Tatsuya Misawa
Gastrointestinal endoscopy is an important tool for the indentification and treatment of disorders of the gastrointestinal tract. However, nosocomial infections of Helicobacter pylori have been linked to the use of contaminated endoscopes. Disinfectants such as glutaraldehyde, ortho-phthalaldehyde and peracetic acid are generally used in the reprocesssing of endoscopes, but these chemicals are hazardous to human health. Thus, safer reprocessing and disinfecion methods are needed. In this study, we applied a dielectric barrier discharge (DBD) plasma torch for inactivation of H...
February 19, 2018: Chemosphere
B Merk, D Litskevich, R Gregg, A R Mount
The PUREX technology based on aqueous processes is currently the leading reprocessing technology in nuclear energy systems. It seems to be the most developed and established process for light water reactor fuel and the use of solid fuel. However, demand driven development of the nuclear system opens the way to liquid fuelled reactors, and disruptive technology development through the application of an integrated fuel cycle with a direct link to reactor operation. The possibilities of this new concept for innovative reprocessing technology development are analysed, the boundary conditions are discussed, and the economic as well as the neutron physical optimization parameters of the process are elucidated...
2018: PloS One
Charles M Laymon, Davneet S Minhas, Carl R Becker, Cristy Matan, Matthew J Oborski, Julie C Price, James M Mountz
PURPOSE: In dual modality positron emission tomography (PET)/magnetic resonance imaging (MRI), attenuation correction (AC) methods are continually improving. Although a new AC can sometimes be generated from existing MR data, its application requires a new reconstruction. We evaluate an approximate 2D projection method that allows offline image-based reprocessing. PROCEDURE: 2-Deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) brain scans were acquired (Siemens HR+) for six subjects...
February 27, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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