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https://www.readbyqxmd.com/read/29241704/development-and-characterization-of-an-anthropomorphic-breast-phantom-for-permanent-breast-seed-implant-brachytherapy-credentialing
#1
Michael Roumeliotis, Sarah Quirk, Matthew Skarsgard, Tiana Trumpour, Elizabeth Watt, Tyler Meyer
PURPOSE: To develop an anthropomorphic breast phantom for use in credentialing of permanent breast seed implant brachytherapy. METHODS AND MATERIALS: A representative external contour and target volume was used as the basis of mold manufacturing for anthropomorphic breast phantom development. Both target and normal tissue were composed of gel-like materials that provide suitable computed tomography and ultrasound contrast for brachytherapy delivery. The phantoms were evaluated for consistency in construction (target location) and Hounsfield unit (computed tomography contrast)...
December 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29192507/effect-of-transcranial-direct-current-stimulation-in-patients-with-tinnitus-a-meta-analysis-and-systematic-review
#2
Tang-Chuan Wang, Richard S Tyler, Ta-Yuan Chang, Jui-Cheng Chen, Chia-Der Lin, Hsiung-Kwang Chung, Yung-An Tsou
OBJECTIVES: Subjective tinnitus is a phantom sensation experienced without any external source of sound that profoundly impacts the quality of life. Some investigations have claimed that transcranial direct current stimulation (tDCS) reduces tinnitus, but studies on tDCS have demonstrated variable results. This meta-analysis aimed to examine the effect of tDCS on patients with tinnitus. METHODS: We searched for articles published through January 5, 2016, in Medline, Cochrane, EMBASE, and Google Scholar using the following keywords: tinnitus, transcranial direct current stimulation, and tDCS...
November 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29185067/phantom-validation-of-quantitative-y-90-pet-ct-based-dosimetry-in-liver-radioembolization
#3
Marco D'Arienzo, Maria Pimpinella, Marco Capogni, Vanessa De Coste, Luca Filippi, Emiliano Spezi, Nick Patterson, Francesca Mariotti, Paolo Ferrari, Paola Chiaramida, Michael Tapner, Alexander Fischer, Timo Paulus, Roberto Pani, Giuseppe Iaccarino, Marco D'Andrea, Lidia Strigari, Oreste Bagni
BACKGROUND: PET/CT has recently been shown to be a viable alternative to traditional post-infusion imaging methods providing good quality images of 90Y-laden microspheres after selective internal radiation therapy (SIRT). In the present paper, first we assessed the quantitative accuracy of 90Y-PET using an anthropomorphic phantom provided with lungs, liver, spine, and a cylindrical homemade lesion located into the hepatic compartment. Then, we explored the accuracy of different computational approaches on dose calculation, including (I) direct Monte Carlo radiation transport using Raydose, (II) Kernel convolution using Philips Stratos, (III) local deposition algorithm, (IV) Monte Carlo technique (MCNP) considering a uniform activity distribution, and (V) MIRD (Medical Internal Radiation Dose) analytical approach...
November 28, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29160776/proton-range-verification-in-homogeneous-materials-through-acoustic-measurements
#4
Wei Nie, Kevin C Jones, Scott Petro, Alireza Kassaee, Chandra M Sehgal, Stephen Avery
Clinical proton beam quality assurance (QA) requires a simple and accurate method to measure the proton beam Bragg peak (BP) depth. Protoacoustics, the measurement of the pressure waves emitted by thermal expansion resulting from proton dose deposition, may be used to obtain the depth of the BP in a phantom by measuring the time-of-flight (TOF) of the pressure wave. Rectangular and cylindrical phantoms of different materials (aluminum, lead, and polyethylene) were used for protoacoustic studies. Four different methods for analyzing the protoacoustic signals are compared...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29092614/the-production-of-phantom-partials-due-to-nonlinearities-in-the-structural-components-of-the-piano
#5
Eric Rokni, Lauren M Neldner, Camille Adkison, Thomas R Moore
Phantom partials are anomalous overtones in the spectrum of the piano sound that occur at sum and difference frequencies of the natural overtones of the string. Although they are commonly assumed to be produced by forced longitudinal waves in the string, analysis of the sound of a piano produced by mechanically vibrating the soundboard while all the strings are damped indicates that phantom partials can occur in the absence of string motion. The magnitude of the effect leads to the conclusion that nonlinearity in the non-string components may be responsible for some of the power in the phantom partials...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29080282/assessment-of-the-effect-of-strontium-lead-and-aluminum-in-bone-on-dual-energy-x-ray-absorptiometry-and-quantitative-ultrasound-measurements-a-phantom-study
#6
Deok Hyun Jang, Eric Da Silva, Jahan Tavakkoli, Lubomira Slatkovska, Angela M Cheung, Ana Pejović-Milić
PURPOSE: Dual-energy X-ray absorptiometry (DXA) is the gold standard technique to measure areal bone mineral density (aBMD) for the diagnosis of osteoporosis. Because DXA relies on the attenuation of photon to estimate aBMD, deposition of bone-seeking metallic elements such as strontium, lead and aluminum that differ in atomic numbers from calcium can cause inaccurate estimation of aBMD. Quantitative ultrasound (QUS), is another technique available to assess bone health by measuring broadband ultrasound attenuation (BUA), speed of sound (SOS) and an empirically derived quantity called stiffness index (SI)...
October 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/29071034/alterations-in-auditory-electrophysiological-responses-associated-with-temporary-suppression-of-tinnitus-induced-by-low-level-laser-therapy-a-before-after-case-series
#7
Katayoon Montazeri, Saeid Mahmoudian, Zahra Razaghi, Mohammad Farhadi
Introduction: Tinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus. The treatment is difficult due to multiple etiologies and great psychological influence. The purpose of this study was to determine alterations in auditory physiological and electrophysiological responses associated with temporary suppression of tinnitus induced by low-level laser (LLL) irradiation. Methods: This study was conducted on 20 subjects with subjective tinnitus. All subjects signed the informed consent form and satisfied all the study eligibility criteria...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29066019/assessment-of-coded-excitation-implementation-for-estimating-heat-induced-speed-of-sound-changes
#8
Oren Gargir, Haim Azhari, Michael Zibulevsky
Speed of sound (SoS) is an acoustic property that is highly sensitive to changes in tissues. SoS can be mapped non-invasively using ultrasonic through transmission wave tomography. This however, practically limits its clinical use to the breast. A pulse-echo-based method that has broader clinical use and that can reliably measure treatment-induced changes in SoS even under poor signal-to-noise ratio (SNR) is highly desirable. The aim of this study was to evaluate the implementation of coded excitations (CoEs) to improve pulse-echo monitoring of heat-induced changes in the SoS...
October 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29064602/brain-stimulation-induced-neuroplasticity-underlying-therapeutic-response-in-phantom-sounds
#9
Timm B Poeppl, Berthold Langguth, Astrid Lehner, Thomas Frodl, Rainer Rupprecht, Peter M Kreuzer, Michael Landgrebe, Martin Schecklmann
Noninvasive brain stimulation can modify phantom sounds for longer periods by modulating neural activity and putatively inducing regional neuroplastic changes. However, treatment response is limited and there are no good demographic or clinical predictors for treatment outcome. We used state-of-the-art voxel-based morphometry (VBM) to investigate whether transcranial magnetic stimulation-induced neuroplasticity determines therapeutic outcome. Sixty subjects chronically experiencing phantom sounds (i.e., tinnitus) received repetitive transcranial magnetic stimulation (rTMS) of left dorsolateral prefrontal and temporal cortex according to a protocol that has been shown to yield a significantly higher number of treatment responders than sham stimulation and previous stimulation protocols...
October 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29063825/target-visualisation-and-microwave-hyperthermia-monitoring-using-nanoparticle-enhanced-transmission-ultrasound-netus
#10
Or Perlman, Iris S Weitz, Haim Azhari
PURPOSE: The aim of this study was to examine the feasibility of using nanoparticle-enhanced transmission ultrasound (NETUS) as an image-based monitoring modality for microwave hyperthermia treatment. METHODS: A dedicated transmission ultrasound imaging system was used to obtain acoustic projections and ultrasound computed tomography images. Initially, speed-of-sound based images were used to non-invasively monitor temperature changes in in vitro and ex vivo specimens, induced by a microwave needle-type applicator...
October 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29060509/non-invasive-diagnosis-of-non-alcoholic-fatty-liver-disease-nafld-using-ultrasound-image-echogenicity
#11
Alex Benjamin, Rebecca Zubajlo, Kai Thomenius, Manish Dhyani, Kanakaraju Kaliannan, Anthony E Samir, Brian W Anthony
This paper introduces a non-invasive, quantitative technique to diagnose the progression of non-alcoholic fatty liver disease (NAFLD). The method is predicated on two fundamental principles: 1) the speed of sound in a fatty liver is lower than that in a healthy liver and 2) the quality of an ultrasound image is maximized when the beamformer's speed of sound matches the true speed of sound in the tissue being examined. The proposed method uses the echogenicity of an ultrasound image as a quantitative measure to estimate the true speed of sound within the liver parenchyma and capture its correlation with the underlying fat content...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052372/two-layer-heterogeneous-breast-phantom-for-photoacoustic-imaging
#12
Congxian Jia, William C Vogt, Keith A Wear, T Joshua Pfefer, Brian S Garra
Photoacoustic tomography (PAT) is emerging as a potentially important aid for breast cancer detection. Well-validated tissue-simulating phantoms are needed for objective, quantitative, and physically realistic testing for system development. Prior reported PAT phantoms with homogenous structures do not incorporate the irregular layered structure of breast tissue. To assess the impact of this simplification, we design and construct two-layer breast phantoms incorporating vessel-simulating inclusions and realistic undulations at the fat/fibroglandular tissue interface...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29024959/limb-laterality-recognition-score-a-reliable-clinical-measure-related-to-phantom-limb-pain
#13
Christopher Kevin Wong, Caitlin Kimberly Wong
Objective: To explore the usefulness of the limb laterality recognition score as a clinical measure of phantom limb pain, regarding test-retest reliability and association of limb laterality recognition scores with phantom limb pain measures. Design: Retrospective cohort. Setting: Community support group. Subjects: Eleven adults who averaged 4.8 years since lower limb amputation due to vascular pathologies (N = 9), trauma (N = 1), and cancer (N = 1)...
August 24, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28982139/a-bayesian-computational-basis-for-auditory-selective-attention-using-head-rotation-and-the-interaural-time-difference-cue
#14
Dillon A Hambrook, Marko Ilievski, Mohamad Mosadeghzad, Matthew Tata
The process of resolving mixtures of several sounds into their separate individual streams is known as auditory scene analysis and it remains a challenging task for computational systems. It is well-known that animals use binaural differences in arrival time and intensity at the two ears to find the arrival angle of sounds in the azimuthal plane, and this localization function has sometimes been considered sufficient to enable the un-mixing of complex scenes. However, the ability of such systems to resolve distinct sound sources in both space and frequency remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/28929305/auditory-display-for-fluorescence-guided-open-brain-tumor-surgery
#15
David Black, Horst K Hahn, Ron Kikinis, Karin Wårdell, Neda Haj-Hosseini
PURPOSE: Protoporphyrin (PpIX) fluorescence allows discrimination of tumor and normal brain tissue during neurosurgery. A handheld fluorescence (HHF) probe can be used for spectroscopic measurement of 5-ALA-induced PpIX to enable objective detection compared to visual evaluation of fluorescence. However, current technology requires that the surgeon either views the measured values on a screen or employs an assistant to verbally relay the values. An auditory feedback system was developed and evaluated for communicating measured fluorescence intensity values directly to the surgeon...
September 19, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28928766/genetics-of-tinnitus-time-to-biobank-phantom-sounds
#16
Christopher R Cederroth, Anna K Kähler, Patrick F Sullivan, Jose A Lopez-Escamez
Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists. While the existing evidence for a genetic influence on the condition has been until now sparse and underpowered, recent data suggest that specific forms of tinnitus have a strong genetic component revealing that not all tinnitus percepts are alike, at least in how they are genetically driven. These new findings pave the way for a better understanding on how phantom sensations are molecularly driven and call for international biobanking efforts...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28926968/weakening-pin-bone-attachment-in-fish-fillets-using-high-intensity-focused-ultrasound
#17
Martin H Skjelvareid, Svein Kristian Stormo, Kristín Anna Þórarinsdóttir, Karsten Heia
High Intensity Focused Ultrasound (HIFU) can be used for the localized heating of biological tissue through the conversion of sound waves into heat. Although originally developed for human medicine, HIFU may also be used to weaken the attachment of pin bones in fish fillets to enable easier removal of such bones. This was shown in the present study, where a series of experiments were performed on HIFU phantoms and fillets of cod and salmon. In thin objects such as fish fillets, the heat is mainly dissipated at the surfaces...
September 18, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28724501/noise-exposure-alters-long-term-neural-firing-rates-and-synchrony-in-primary-auditory-and-rostral-belt-cortices-following-bimodal-stimulation
#18
Joseph D Takacs, Taylor J Forrest, Gregory J Basura
We previously demonstrated that bimodal stimulation (spinal trigeminal nucleus [Sp5] paired with best frequency tone) altered neural tone-evoked and spontaneous firing rates (SFRs) in primary auditory cortex (A1) 15 min after pairing in guinea pigs with and without noise-induced tinnitus. Neural responses were enhanced (+10 ms) or suppressed (0 ms) based on the bimodal pairing interval. Here we investigated whether bimodal stimulation leads to long-term (up to 2 h) changes in tone-evoked and SFRs and neural synchrony (correlate of tinnitus) and if the long-term bimodal effects are altered following noise exposure...
July 13, 2017: Hearing Research
https://www.readbyqxmd.com/read/28709732/medial-geniculate-neurons-show-diverse-effects-in-response-to-electrical-stimulation-of-prefrontal-cortex
#19
K M Barry, D Robertson, W H A M Mulders
Phantom perceptions have been proposed to arise due to dysfunctional sensory gating at the level of the thalamus. Recently, it has been suggested that tinnitus, a phantom perception of sound, may arise from altered cortico-limbic circuitry and its connection with the auditory thalamus, the medial geniculate nucleus (MGN). Indeed, some elements of this cortico-limbic circuitry, such as the prefrontal cortex (PFC), as well as elements of the auditory pathway, have been shown to be altered in humans with tinnitus...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28652968/acute-effects-and-after-effects-of-acoustic-coordinated-reset-neuromodulation-in-patients-with-chronic-subjective-tinnitus
#20
Ilya Adamchic, Timea Toth, Christian Hauptmann, Martin Walger, Berthold Langguth, Ingrid Klingmann, Peter Alexander Tass
Chronic subjective tinnitus is an auditory phantom phenomenon characterized by abnormal neuronal synchrony in the central auditory system. As shown computationally, acoustic coordinated reset (CR) neuromodulation causes a long-lasting desynchronization of pathological synchrony by downregulating abnormal synaptic connectivity. In a previous proof of concept study acoustic CR neuromodulation, employing stimulation tone patterns tailored to the dominant tinnitus frequency, was compared to noisy CR-like stimulation, a CR version significantly detuned by sparing the tinnitus-related pitch range and including substantial random variability of the tone spacing on the frequency axis...
2017: NeuroImage: Clinical
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