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https://www.readbyqxmd.com/read/28303087/a-pilot-genome-wide-association-study-identifies-potential-metabolic-pathways-involved-in-tinnitus
#1
Annick Gilles, Guy Van Camp, Paul Van de Heyning, Erik Fransen
Tinnitus, the perception of an auditory phantom sound in the form of ringing, buzzing, roaring, or hissing in the absence of an external sound source, is perceived by ~15% of the population and 2.5% experiences a severely bothersome tinnitus. The contribution of genes on the development of tinnitus is still under debate. The current manuscript reports a pilot Genome Wide Association Study (GWAS) into tinnitus, in a small cohort of 167 independent tinnitus subjects, and 749 non-tinnitus controls, who were collected as part of a cross-sectional study...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28287955/accurate-3-d-profile-extraction-of-skull-bone-using-an-ultrasound-matrix-array
#2
Mehdi Hajian, Robert Gaspar, Roman Maev
The present study investigates the feasibility, accuracy, and precision of 3-D profile extraction of the human skull bone using a custom-designed ultrasound matrix transducer in Pulse-Echo. Due to the attenuative scattering properties of the skull, the backscattered echoes from the inner surface of the skull are severely degraded, attenuated, and at some points overlapped. Furthermore, the speed of sound (SOS) in the skull varies significantly in different zones and also from case to case; if considered constant, it introduces significant error to the profile measurement...
March 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28260394/evidence-for-behaviorally-segregated-spatio-temporally-overlapping-subnetworks-in-phantom-sound-perception
#3
Anusha Mohan, Nicole Moreno, Jae-Jin Song, Dirk De Ridder, Sven Vanneste
One of the most intriguing questions in neuroscience is to understand the mechanism of information transfer between different brain areas. Recently, network theory has gained traction and is at the forefront of providing a possible explanation to not only the mechanism of information transfer, but also in the identification of different neuropathologies. The perception of a phantom ringing in the ear called tinnitus, similar to other neuropathologies, has been shown to be accompanied by aberrant functional connectivity between different brain areas...
March 6, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28253670/in-vivo-ultrasonic-attenuation-in-cetacean-soft-tissues
#4
Michael D Gray, Peter H Rogers
In vivo ultrasonic attenuation was estimated for extracranial soft tissues of two Tursiops truncatus and one Delphinapterus leucas. Backscatter data was non-invasively collected as part of routine health-based ultrasound examinations using a transducer operating in the 1.6-3.7 MHz frequency range. Data collected over the proximal mandible and temporal regions was processed to yield attenuation estimates using a reference tissue phantom whose properties had been independently determined. The estimated attenuations were at the low end of the range of literature-reported values for mammalian fatty and connective tissues...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28225357/robust-sound-speed-estimation-for-ultrasound-based-hepatic-steatosis-assessment
#5
Imbault Marion, Alex Faccinetto, Bruno-Felix Osmanski, Antoine Tissier, Thomas Deffieux, Jean-Luc Gennisson, Valerie Vilgrain, Mickael Tanter
Hepatic steatosis is a common condition, the prevalence of which is increasing along with non-alcoholic fatty liver disease (NAFLD). Currently, the most accurate noninvasive imaging method for diagnosing and quantifying hepatic steatosis is MRI, which estimates the Proton-Density Fat Fraction (PDFF) as a measure of fractional fat content. However, MRI suffers several limitations including cost, contra-indications and poor availability. Although conventional ultrasound is widely used by radiologists for hepatic steatosis assessment, it remains qualitative and operator dependent...
February 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28192822/-tinnitus-clinical-symptoms-and-therapy
#6
Birgit Mazurek, Agnieszka J Szczepek, Petra Brüggemann
Tinnitus is a phantom sound that can be a symptom of various disorders such as hearing loss, cardiovascular diseases, neurological disorders, diabetes or tumors. Because of the inability to divert the auditory attention from tinnitus sound, patients suffer with insomnia, problems with concentration and other psychological conditions, in some extreme cases including major depression symptoms. The auditory character of tinnitus induces the patients to seek help predominantly at the otolaryngologist practice. The first aim of a physician is to establish the cause of tinnitus and to measure its audiological properties...
January 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28174532/resting-state-brain-abnormalities-in-chronic-subjective-tinnitus-a-meta-analysis
#7
Yu-Chen Chen, Fang Wang, Jie Wang, Fan Bo, Wenqing Xia, Jian-Ping Gu, Xindao Yin
Purpose: The neural mechanisms that give rise to the phantom sound of tinnitus have not been fully elucidated. Neuroimaging studies have revealed abnormalities in resting-state activity that could represent the neural signature of tinnitus, but there is considerable heterogeneity in the data. To address this issue, we conducted a meta-analysis of published neuroimaging studies aimed at identifying a common core of resting-state brain abnormalities in tinnitus patients. Methods: A systematic search was conducted for whole-brain resting-state neuroimaging studies with SPECT, PET and functional MRI that compared chronic tinnitus patients with healthy controls...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28165334/sensitivity-of-simulated-transcranial-ultrasound-fields-to-acoustic-medium-property-maps
#8
James Robertson, Eleanor Martin, Ben Cox, Bradley E Treeby
High intensity transcranial focused ultrasound is an FDA approved treatment for essential tremor, while low-intensity applications such as neurostimulation and opening the blood brain barrier are under active research. Simulations of transcranial ultrasound propagation are used both for focusing through the skull, and predicting intracranial fields. Maps of the skull acoustic properties are necessary for accurate simulations, and can be derived from medical images using a variety of methods. The skull maps range from segmented, homogeneous models, to fully heterogeneous models derived from medical image intensity...
April 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28160746/selective-attentional-impairment-in-chronic-tinnitus-evidence-from-an-event-related-potentials-study
#9
Daniela Mannarelli, Caterina Pauletti, Patrizia Mancini, Alessandra Fioretti, Antonio Greco, Marco De Vincentiis, Francesco Fattapposta
OBJECTIVE: Tinnitus is an auditory phantom sensation experienced in the absence of a sound source. Cognitive dysfunctions, especially in working memory and attention, are frequently reported to be associated with tinnitus. The aim of this study was to investigate attentional functioning in a group of subjects with chronic tinnitus using ERPs, and in particular the P300 components. METHODS: We studied 20 patients with chronic tinnitus and 20 healthy subjects that performed a P300 Novelty task...
March 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28112466/tinnitus-distress-is-linked-to-enhanced-resting-state-functional-connectivity-from-the-limbic-system-to-the-auditory-cortex
#10
Yu-Chen Chen, Wenqing Xia, Huiyou Chen, Yuan Feng, Jin-Jing Xu, Jian-Ping Gu, Richard Salvi, Xindao Yin
The phantom sound of tinnitus is believed to be triggered by aberrant neural activity in the central auditory pathway, but since this debilitating condition is often associated with emotional distress and anxiety, these comorbidities likely arise from maladaptive functional connections to limbic structures such as the amygdala and hippocampus. To test this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to identify aberrant effective connectivity of the amygdala and hippocampus in tinnitus patients and to determine the relationship with tinnitus characteristics...
January 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28072813/a-case-report-on-red-ear-syndrome-with-tinnitus-successfully-treated-with-transcranial-random-noise-stimulation
#11
Peter M Kreuzer, Veronika Vielsmeier, Timm B Poeppl, Berthold Langguth
BACKGROUND: The red ear syndrome represents a rare symptom complex consisting of auricular erythema associated with painful and burning sensations. It has been described in combination with tinnitus rarely. It has been hypothesized to be etiologically related to altered trigeminal afferent input, temporomandibular disorders, and thalamic dysfunction. OBJECTIVES: The initial objective of applying transcranial random noise stimulation (tRNS) in a case of red ear syndrome in combination with tinnitus was the alleviation of the phantom sounds...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28072576/ultrasonic-computed-tomography-imaging-of-iron-oxide-nanoparticles
#12
Or Perlman, Haim Azhari
Iron oxide nanoparticles (IONPs) are becoming increasingly used and intensively investigated in the field of medical imaging. They are currently FDA approved for magnetic resonance imaging (MRI), and it would be highly desirable to visualize them by ultrasound as well. Previous reports using the conventional ultrasound B-scan (pulse-echo) imaging technique have shown very limited detectability of these particles. The aim of this study is to explore the feasibility of imaging IONPs using the through-transmission ultrasound methodology and demonstrate their detectability using ultrasonic computed tomography (UCT)...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28053240/broadened-population-level-frequency-tuning-in-the-auditory-cortex-of-tinnitus-patients
#13
Kenichi Sekiya, Mariko Takahashi, Shingo Murakami, Ryusuke Kakigi, Hidehiko Okamoto
Tinnitus is a phantom auditory perception without an external sound source and is one of the most common public health concerns that impair the quality of life of many individuals. However, its neural mechanisms remain unclear. We herein examined population-level frequency tuning in the auditory cortex of unilateral tinnitus patients with similar hearing levels in both ears using magnetoencephalography. We compared auditory-evoked neural activities elicited by a stimulation to the tinnitus and nontinnitus ears...
March 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28048787/su-f-i-14-3d-breast-digital-phantom-for-xact-imaging
#14
S Tang, Y Chen, S Ahmad, K Yang, R Laaroussi, J Chen, P Samant, L Xiang
PURPOSE: The X-ray induced acoustic computed tomography (XACT) is a new imaging modality which combines X-ray contrast and high ultrasonic resolution in a single modality. Using XACT in breast imaging, a 3D breast volume can be imaged by only one pulsed X-ray radiation, which could dramatically reduce the imaging dose for patients undergoing breast cancer screening and diagnosis. A 3D digital phantom that contains both X-ray properties and acoustic properties of different tissue types is indeed needed for developing and optimizing the XACT system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048325/th-cd-202-07-a-methodology-for-generating-numerical-phantoms-for-radiation-therapy-using-geometric-attribute-distribution-models
#15
S Dolly, H Chen, S Mutic, M Anastasio, H Li
PURPOSE: A persistent challenge for the quality assessment of radiation therapy treatments (e.g. contouring accuracy) is the absence of the known, ground truth for patient data. Moreover, assessment results are often patient-dependent. Computer simulation studies utilizing numerical phantoms can be performed for quality assessment with a known ground truth. However, previously reported numerical phantoms do not include the statistical properties of inter-patient variations, as their models are based on only one patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047878/th-ab-209-06-an-investigation-of-the-feasibility-of-malignant-lesion-detection-during-routine-breast-cancer-screening-using-a-prototype-acousto-optic-transmission-ultrasound-imaging-system
#16
J R Rosenfield, J S Sandhu, P J La Riviere
PURPOSE: To investigate the feasibility of malignant lesion detection during routine breast cancer screening using an acousto-optic (AO) transmission ultrasound imaging system, particularly in premenopausal women with high breast density. METHODS: A full-field, single-projection ultrasound imaging system was developed that uses a high-resolution AO detector to convert the acoustic intensity transmitted through the compressed breast into a visual image by virtue of the AO effect in nematic liquid crystals...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047007/we-de-bra-03-construction-of-an-ultrasound-guidance-platform-for-image-guided-radiotherapy-with-the-intent-to-treat-transitional-cell-carcinoma
#17
J Sick, N Rancilio, C Fulkerson, P LaPetina, J Poulson, D Knapp, K Stantz
PURPOSE: Ultrasound (US) is a noninvasive, nonradiographic imaging technique with high spatial and temporal resolution that can be used for localizing soft-tissue structures and tumors in real-time during radiotherapy (inter- and intra-fraction). A detailed methodology integrating 3D-US within RT is presented. This method is easier to adopt into current treatment protocol than current US based systems and reduces user variability for image acquisition, thus eliminating transducer induced changes that limit CT planning system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040043/relationships-of-linear-and-nonlinear-ultrasound-parameters-with-porosity-and-trabecular-spacing-in-trabecular-bone-mimicking-phantoms
#18
Kang Il Lee
The speed of sound (SOS), the normalized broadband ultrasound attenuation (nBUA), and the nonlinear parameter (B/A) were measured in 18 trabecular-bone-mimicking phantoms consisting of water-saturated aluminum foams. The strong slow wave and the very weak fast wave were consistently observed in the signals transmitted through all of the phantoms. It was found that the SOS increased as the porosity and the trabecular spacing increased. In contrast, both the nBUA and the B/A showed opposite dependences on the porosity and the trabecular spacing...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28018210/measuring-the-moment-to-moment-variability-of-tinnitus-the-trackyourtinnitus-smart-phone-app
#19
Winfried Schlee, Rüdiger C Pryss, Thomas Probst, Johannes Schobel, Alexander Bachmeier, Manfred Reichert, Berthold Langguth
Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnitus perception fluctuates over time. It is therefore necessary to develop tools for measuring fluctuations of tinnitus perception over time and for analyzing data on single subject basis. However, this type of longitudinal measurement is difficult to perform using the traditional research methods such as paper-and-pencil questionnaires or clinical interviews...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27997374/stable-phantom-materials-for-ultrasound-and-optical-imaging
#20
Luciana C Cabrelli, Pedro I B G B Pelissari, Alessandro M Deana, Antonio A O Carneiro, Theo Z Pavan
Phantoms mimicking the specific properties of biological tissues are essential to fully characterize medical devices. Water-based materials are commonly used to manufacture phantoms for ultrasound and optical imaging techniques. However, these materials have disadvantages, such as easy degradation and low temporal stability. In this study, we propose an oil-based new tissue-mimicking material for ultrasound and optical imaging, with the advantage of presenting low temporal degradation. A styrene-ethylene/butylene-styrene (SEBS) copolymer in mineral oil samples was made varying the SEBS concentration between 5%-15%, and low-density polyethylene (LDPE) between 0%-9%...
December 20, 2016: Physics in Medicine and Biology
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