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https://www.readbyqxmd.com/read/28724501/noise-exposure-alters-long-term-neural-firing-rates-and-synchrony-in-primary-auditory-and-rostral-belt-cortices-following-bimodal-stimulation
#1
Joseph D Takacs, Taylor J Forrest, Gregory J Basura
We previously demonstrated that bimodal stimulation (spinal trigeminal nucleus [Sp5] paired with best frequency tone) altered neural tone-evoked and spontaneous firing rates (SFRs) in primary auditory cortex (A1) 15 min after pairing in guinea pigs with and without noise-induced tinnitus. Neural responses were enhanced (+10 ms) or suppressed (0 ms) based on the bimodal pairing interval. Here we investigated whether bimodal stimulation leads to long-term (up to 2 h) changes in tone-evoked and SFRs and neural synchrony (correlate of tinnitus) and if the long-term bimodal effects are altered following noise exposure...
July 13, 2017: Hearing Research
https://www.readbyqxmd.com/read/28709732/medial-geniculate-neurons-show-diverse-effects-in-response-to-electrical-stimulation-of-prefrontal-cortex
#2
K M Barry, D Robertson, W H A M Mulders
Phantom perceptions have been proposed to arise due to dysfunctional sensory gating at the level of the thalamus. Recently, it has been suggested that tinnitus, a phantom perception of sound, may arise from altered cortico-limbic circuitry and its connection with the auditory thalamus, the medial geniculate nucleus (MGN). Indeed, some elements of this cortico-limbic circuitry, such as the prefrontal cortex (PFC), as well as elements of the auditory pathway, have been shown to be altered in humans with tinnitus...
July 8, 2017: Hearing Research
https://www.readbyqxmd.com/read/28652968/acute-effects-and-after-effects-of-acoustic-coordinated-reset-neuromodulation-in-patients-with-chronic-subjective-tinnitus
#3
Ilya Adamchic, Timea Toth, Christian Hauptmann, Martin Walger, Berthold Langguth, Ingrid Klingmann, Peter Alexander Tass
Chronic subjective tinnitus is an auditory phantom phenomenon characterized by abnormal neuronal synchrony in the central auditory system. As shown computationally, acoustic coordinated reset (CR) neuromodulation causes a long-lasting desynchronization of pathological synchrony by downregulating abnormal synaptic connectivity. In a previous proof of concept study acoustic CR neuromodulation, employing stimulation tone patterns tailored to the dominant tinnitus frequency, was compared to noisy CR-like stimulation, a CR version significantly detuned by sparing the tinnitus-related pitch range and including substantial random variability of the tone spacing on the frequency axis...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28648918/acoustic-and-elastic-properties-of-glycerol-in-oil-based-gel-phantoms
#4
Luciana C Cabrelli, Felipe W Grillo, Diego R T Sampaio, Antonio A O Carneiro, Theo Z Pavan
Phantoms are important tools for image quality control and medical training. Many phantom materials have been proposed for ultrasound; most of them use water as the solvent, but these materials have disadvantages such as dehydration and low temporal stability if not properly stored. To overcome these difficulties, copolymer-in-oil gel was proposed as an inert and stable material; however, speed of sound for these materials is still lower than what is described for most biological tissues. Here, we propose the glycerol dispersion in oil-based gels to modify the acoustic and elastic properties of copolymer-in-oil phantoms...
June 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28629874/neural-activity-during-attentional-conflict-predicts-reduction-in-tinnitus-perception-following-rtms
#5
G A James, J D Thostenson, G Brown, G Carter, H Hayes, S P Tripathi, D J Dobry, R B Govindan, J L Dornhoffer, D K Williams, C D Kilts, M S Mennemeier
BACKGROUND: Subjective idiopathic tinnitus is an intrusive, distracting, and potentially disabling disorder characterized by phantom perception of sounds. Although tinnitus has no approved pharmacologic treatment, recent evidence supports the use of repetitive transcranial magnetic stimulation (rTMS) to alleviate tinnitus symptoms. OBJECTIVE/HYPOTHESIS: Repetitive TMS delivered over the middle superior temporal gyrus (STG) may alter ratings of tinnitus awareness and annoyance more than loudness due to change in attentional processing...
June 2, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28626903/economical-sponge-phantom-for-teaching-understanding-and-researching-a-and-b-line-reverberation-artifacts-in-lung-ultrasound
#6
Christian Blüthgen, Sergio Sanabria, Thomas Frauenfelder, Volker Klingmüller, Marga Rominger
This project evaluated a low-cost sponge phantom setup for its capability to teach and study A- and B-line reverberation artifacts known from lung ultrasound and to numerically simulate sound wave interaction with the phantom using a finite-difference time-domain (FDTD) model. Both A- and B-line artifacts were reproducible on B-mode ultrasound imaging as well as in the FDTD-based simulation. The phantom was found to be an easy-to-set up and economical tool for understanding, teaching, and researching A- and B-line artifacts occurring in lung ultrasound...
June 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28604786/tinnitus-alters-resting-state-functional-connectivity-rsfc-in-human-auditory-and-non-auditory-brain-regions-as-measured-by-functional-near-infrared-spectroscopy-fnirs
#7
Juan San Juan, Xiao-Su Hu, Mohamad Issa, Silvia Bisconti, Ioulia Kovelman, Paul Kileny, Gregory Basura
Tinnitus, or phantom sound perception, leads to increased spontaneous neural firing rates and enhanced synchrony in central auditory circuits in animal models. These putative physiologic correlates of tinnitus to date have not been well translated in the brain of the human tinnitus sufferer. Using functional near-infrared spectroscopy (fNIRS) we recently showed that tinnitus in humans leads to maintained hemodynamic activity in auditory and adjacent, non-auditory cortices. Here we used fNIRS technology to investigate changes in resting state functional connectivity between human auditory and non-auditory brain regions in normal-hearing, bilateral subjective tinnitus and controls before and after auditory stimulation...
2017: PloS One
https://www.readbyqxmd.com/read/28541199/3-d-nonlinear-acoustic-inverse-scattering-algorithm-and-quantitative-results
#8
J W Wiskin, D T Borup, E Iuanow, J Klock, Mark W Lenox
We describe a novel 3-D ultrasound technology, the quantitative transmission ultrasound system and algorithm to image a pendent breast in a water bath. Quantitative accuracy is verified using phantoms. Morphological accuracy is verified using cadaveric breast and in vivo images, and spatial resolution is estimated. This paper generalizes an earlier 2-D algorithm to a full 3-D inversion algorithm and shows the importance of such a 3-D algorithm for artifact suppression as compared with the 2-D algorithm. The resultant high-resolution ultrasound images, along with quantitative information regarding tissue speed of sound/stiffness, provide a more accurate depiction of the breast anatomy and lesions, contributing to improved breast care...
August 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28533738/genetics-of-tinnitus-still-in-its-infancy
#9
REVIEW
Barbara Vona, Indrajit Nanda, Wafaa Shehata-Dieler, Thomas Haaf
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general population. Despite this considerable prevalence, treatments for tinnitus are presently lacking. Tinnitus exhibits a diverse array of recognized risk factors and extreme clinical heterogeneity. Furthermore, it can involve an unknown number of auditory and non-auditory networks and molecular pathways. This complex combination has hampered advancements in the field. The identification of specific genetic factors has been at the forefront of several research investigations in the past decade...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28463191/quantifying-backscatter-anisotropy-using-the-reference-phantom-method
#10
Quinton W Guerrero, Ivan M Rosado-Mendez, Lindsey C Drehfal, Helen Feltovich, Timothy J Hall
Acoustic properties can be exploited to infer and evaluate tissue microstructure. However, common assumptions are that the medium of interest is homogeneous and isotropic, and that its underlying physical properties cause diffuse scattering. In this paper, we describe how we developed and tested novel parameters designed to address isotropy/anisotropy in backscattered echo signal power in complex biological tissues. Specifically, we explored isotropy/anisotropy in backscattered power in isotropic phantoms (spherical glass beads), an anisotropic phantom (dialysis phantom with rodlike fibers), and an in vivo human tissue with well-described anisotropy (bicep muscle)...
July 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28450032/broadband-acoustic-measurement-of-an-agar-based-tissue-mimicking-material-a-longitudinal-study
#11
Adela Rabell Montiel, Jacinta E Browne, Stephen D Pye, Tom A Anderson, Carmel M Moran
Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics...
April 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28418323/the-personality-profile-of-tinnitus-sufferers-and-a-nontinnitus-control-group
#12
Mithila Durai, Mary G O'Keeffe, Grant D Searchfield
BACKGROUND: Chronic tinnitus (phantom perception of sound) significantly disrupts quality of life in 15-20% of those who experience it. Understanding how certain personality traits impact tinnitus perception and distress can be beneficial for the development of interventions to improve the lives of tinnitus sufferers. PURPOSE: Four key self-reported personality traits (social closeness, stress reaction, alienation, and self-control) were identified from previous research as being associated with tinnitus...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28415122/p1138cardiac-shear-wave-velocity-in-healthy-individuals
#13
M Strachinaru, M L Geleijnse, J G Bosch, N De Jong, Afw Van Der Steen, B M Van Dalen, H J Vos
Background: The closure of the valves generates shear waves in the heart walls. The propagation velocity of shear waves relates to stiffness. This could potentially be used to estimate the stiffness of the myocardium, with huge potential implications in pathologies characterized by a deterioration of the diastolic properties of the left ventricle. In an earlier phantom study we already validated shear wave tracking with a clinical ultrasound system in cardiac mode. Purpose: In this study we aimed to measure the shear waves velocity in normal individuals...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28386578/large-field-of-view-optical-elastography-using-digital-image-correlation-for-biological-soft-tissue-investigation
#14
Daniel Claus, Marijo Mlikota, Jonathan Geibel, Thomas Reichenbach, Giancarlo Pedrini, Johannes Mischinger, Siegfried Schmauder, Wolfgang Osten
In minimally invasive surgery the haptic feedback, which represents an important tool for the localization of abnormalities, is no longer available. Elastography is an imaging technique that results in quantitative elastic parameters. It can hence be used to replace the lost sense of touch, as to enable tissue localization and discrimination. Digital image correlation is the chosen elastographic imaging technique. The implementation discussed here is clinically sound, based on a spectrally engineered illumination source that enables imaging of biological surface markers (blood vessels) with high contrast...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28384210/thermal-characteristics-of-non-biological-vessel-phantoms-for-treatment-of-varicose-veins-using-high-intensity-focused-ultrasound
#15
Mi-Sun Kim, Ju-Young Kim, Si-Cheol Noh, Heung-Ho Choi
The ultrasonic treatment of varicose veins uses high-intensity focused ultrasound, in which a blood vessel is contracted by converting acoustic energy into thermal energy. In this study, we propose a phantom of varicose veins that can be applied for the efficient evaluation of ultrasonic treatment in varicose veins. The proposed phantom consisted of glycerol base tissue equivalent material, vessel mimic tube, and blood mimic substances. The vessel mimic tube was placed inner glycerol phantom and it was filled with blood mimic substances...
2017: PloS One
https://www.readbyqxmd.com/read/28372078/time-domain-reconstruction-of-sound-speed-and-attenuation-in-ultrasound-computed-tomography-using-full-wave-inversion
#16
M Pérez-Liva, J L Herraiz, J M Udías, E Miller, B T Cox, B E Treeby
Ultrasound computed tomography (USCT) is a non-invasive imaging technique that provides information about the acoustic properties of soft tissues in the body, such as the speed of sound (SS) and acoustic attenuation (AA). Knowledge of these properties can improve the discrimination between benign and malignant masses, especially in breast cancer studies. Full wave inversion (FWI) methods for image reconstruction in USCT provide the best image quality compared to more approximate methods. Using FWI, the SS is usually recovered in the time domain, and the AA is usually recovered in the frequency domain...
March 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28303087/a-pilot-genome-wide-association-study-identifies-potential-metabolic-pathways-involved-in-tinnitus
#17
Annick Gilles, Guy Van Camp, Paul Van de Heyning, Erik Fransen
Tinnitus, the perception of an auditory phantom sound in the form of ringing, buzzing, roaring, or hissing in the absence of an external sound source, is perceived by ~15% of the population and 2.5% experiences a severely bothersome tinnitus. The contribution of genes on the development of tinnitus is still under debate. The current manuscript reports a pilot Genome Wide Association Study (GWAS) into tinnitus, in a small cohort of 167 independent tinnitus subjects, and 749 non-tinnitus controls, who were collected as part of a cross-sectional study...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28287955/accurate-3-d-profile-extraction-of-skull-bone-using-an-ultrasound-matrix-array
#18
Mehdi Hajian, Robert Gaspar, Roman Maev
The present study investigates the feasibility, accuracy, and precision of 3-D profile extraction of the human skull bone using a custom-designed ultrasound matrix transducer in Pulse-Echo. Due to the attenuative scattering properties of the skull, the backscattered echoes from the inner surface of the skull are severely degraded, attenuated, and at some points overlapped. Furthermore, the speed of sound (SOS) in the skull varies significantly in different zones and also from case to case; if considered constant, it introduces significant error to the profile measurement...
March 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28260394/evidence-for-behaviorally-segregated-spatiotemporally-overlapping-subnetworks-in-phantom-sound-perception
#19
Anusha Mohan, Nicole Moreno, Jae-Jin Song, Dirk De Ridder, Sven Vanneste
One of the most intriguing questions in neuroscience is to understand the mechanism of information transfer between different brain areas. Recently, network theory has gained traction and is at the forefront of providing a possible explanation to not only the mechanism of information transfer but also in the identification of different neuropathologies. The perception of a phantom ringing in the ear called tinnitus, similar to other neuropathologies, has been shown to be accompanied by aberrant functional connectivity between different brain areas...
April 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28253670/in-vivo-ultrasonic-attenuation-in-cetacean-soft-tissues
#20
Michael D Gray, Peter H Rogers
In vivo ultrasonic attenuation was estimated for extracranial soft tissues of two Tursiops truncatus and one Delphinapterus leucas. Backscatter data was non-invasively collected as part of routine health-based ultrasound examinations using a transducer operating in the 1.6-3.7 MHz frequency range. Data collected over the proximal mandible and temporal regions was processed to yield attenuation estimates using a reference tissue phantom whose properties had been independently determined. The estimated attenuations were at the low end of the range of literature-reported values for mammalian fatty and connective tissues...
February 2017: Journal of the Acoustical Society of America
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