keyword
https://read.qxmd.com/read/38322463/impact-of-body-mass-index-on-adverse-kidney-events-in-diabetes-mellitus-patients-a-systematic-review-and-meta-analysis
#21
JOURNAL ARTICLE
Jing-Fang Wan, Yan Chen, Tian-Hua Yao, Ya-Zhou Wu, Huan-Zi Dai
BACKGROUND: The incidence of chronic kidney disease among patients with diabetes mellitus (DM) remains a global concern. Long-term obesity is known to possibly influence the development of type 2 diabetes mellitus. However, no previous meta-analysis has assessed the effects of body mass index (BMI) on adverse kidney events in patients with DM. AIM: To determine the impact of BMI on adverse kidney events in patients with DM. METHODS: A systematic literature search was performed on the PubMed, ISI Web of Science, Scopus, Ovid, Google Scholar, EMBASE, and BMJ databases...
January 26, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38319613/effects-of-allisartan-isoproxil-based-combination-antihypertensive-regimen-in-hypertensive-patients-with-microalbuminuria-or-hyperuricemia
#22
JOURNAL ARTICLE
Ningling Sun, Hongyi Wang
Microalbuminuria and hyperuricemia management are crucial for the integrated management of hypertensive patients. This retrospective post hoc analysis aims to evaluate the optimal allisartan-isoproxil-based combination regimen for hypertensive patients with microalbuminuria or hyperuricemia. A total of 460 hypertensive patients with microalbuminuria and 486 hypertensive patients with hyperuricemia were included in this study. All patients were initially treated with allisartan-isoproxil for 4 weeks. Thereafter, patients with blood pressure (BP) < 140/90 mmHg continued the monotherapy for 8 weeks; patients with BP ≥140/90 mmHg were randomly assigned in a 1:1 ratio to receive allisartan-isoproxil + amlodipine (Group A + C) or allisartan-isoproxil + indapamide (Group A + D) for 8 weeks...
February 6, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38314940/microalbuminuria-and-functional-iron-deficiency-are-risk-factors-for-hearing-loss-in-adolescents
#23
JOURNAL ARTICLE
Sang-Yoon Han, Young Ho Kim
OBJECTIVES: Renal impairment and some systemic diseases are associated with hearing loss (HL) in adults. However, studies of these relationship in adolescents are rare. The objective of this study was to determine the association between HL and renal or systemic disease in adolescents. METHODS: Subjects were extracted from the 5th Korea National Health and Nutrition Examination Survey from 2011 to 2012. We included adolescents aged 10-19 years old with normal tympanic membrane and those who underwent a physical and laboratory examination and pure tone audiometry...
February 5, 2024: Laryngoscope
https://read.qxmd.com/read/38291519/an-elevated-urinary-albumin-to-creatinine-ratio-increases-the-risk-of-incident-cardia-cerebrovascular-disease-in-individuals-with-type-2-diabetes
#24
JOURNAL ARTICLE
Jie Tao, Dasen Sang, Xinxin Zhang, Xin Liu, Guodong Wang, Shuohua Chen, Shouling Wu, Wei Geng
AIMS: We aimed to explore the associations between urine albumin-to-creatinine ratio (uACR) and cardia-cerebrovascular disease (CVD) in Chinese population with type 2 diabetes(T2D). METHODS: We included 8975 participants with T2D but free of prevalent CVD (including myocardial infarction, ischemic and hemorrhagic stroke) at baseline from Kailuan study who were assessed with uACR between 2014 and 2016. The participants were divided into three groups based on their baseline uACR: normal (< 3 mg/mmol), microalbuminuria (3-30 mg/mmol), and macroalbuminuria (≥ 30 mg/mmol)...
January 31, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38280517/pediatric-kidney-dimensions-and-risk-of-persistent-albuminuria-in-mexican-adolescents
#25
JOURNAL ARTICLE
Mónica Linneth Alcalde-Ortiz, Fernando Jaramillo-Arriaga, Daniel Ibarra-Orenday, Salomón Israel González-Domínguez, Héctor David Calzada-Gallegos, Alma Alejandra Pinales-Jiménez, Itzel Alondra Carrillo-Aguilera, Dimitri Alejandro Flota-Marin, Mariana Guadalupe Collazo-Zamores, Paola Daniela Aguirre-Moreno, Siddhartha Denise Gutiérrez-Hernández, Valeria Del Toro-Delgado, Rodolfo Delgadillo-Castañeda, María Del Rosario Sánchez-Ortiz, Irene Sánchez-González, Carmen Lucrecia Ramos-Medellin Pbc, Alfredo Chew-Wong, Dulce María Macias-Díaz, José Manuel Arreola-Guerra
In Mexico, chronic kidney disease of unknown origin is highly prevalent. Screening studies in adolescents have shown persistent microalbuminuria (pACR), adaptive podocytopathy and decreased kidney volume (KV). Here, we sought to develop normality tables of kidney dimensions by ultrasound in the Mexican state of Aguascalientes pediatric population (0 to 18y) and evaluate the relationship between the KV and pACR among the region´s adolescents in a cross-sectional study. Kidney length (KL) and KV were determined by ultrasound...
January 25, 2024: Kidney International
https://read.qxmd.com/read/38279774/social-deprivation-and-diabetic-kidney-disease-a-european-view
#26
REVIEW
Caoimhe Casey, Claire M Buckley, Patricia M Kearney, Matthew D Griffin, Sean F Dinneen, Tomás P Griffin
There is a large body of literature demonstrating a social gradient in health and increasing evidence of an association between social deprivation and diabetes complications. Diabetic kidney disease (DKD) increases mortality in people with diabetes. Socioeconomic deprivation is increasingly recognized as a modifier of risk factors for kidney disease but also an independent risk factor itself for kidney disease. This may not be truly appreciated by clinicians and warrants further attention and exploration. In this review we explore the literature to date from Europe on the relationship between social deprivation and DKD...
January 27, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38273789/role-of-fenofibrate-use-in-dyslipidemia-and-related-comorbidities-in-the-asian-population-a-narrative-review
#27
REVIEW
Chaicharn Deerochanawong, Sin Gon Kim, Yu-Cheng Chang
Hypertriglyceridemia and decreased high-density lipoprotein cholesterol (HDL-C) persist despite statin therapy, contributing to residual atherosclerotic cardiovascular disease (ASCVD) risk. Asian subjects are metabolically more susceptible to hypertriglyceridemia than other ethnicities. Fenofibrate regulates hypertriglyceridemia, raises HDL-C levels, and is a recommended treatment for dyslipidemia. However, data on fenofibrate use across different Asian regions are limited. This narrative review summarizes the efficacy and safety data of fenofibrate in Asian subjects with dyslipidemia and related comorbidities (diabetes, metabolic syndrome, diabetic retinopathy, and diabetic nephropathy)...
January 26, 2024: Diabetes & Metabolism Journal
https://read.qxmd.com/read/38256599/glucose-metabolism-and-cognitive-decline-in-progressive-supranuclear-palsy-and-corticobasal-syndrome-a-preliminary-study
#28
JOURNAL ARTICLE
Natalia Madetko-Alster, Dagmara Otto-Ślusarczyk, Marta Struga, Michał Kutyłowski, Agnieszka Drzewińska, Karolina Duszyńska-Wąs, Bartosz Migda, Piotr Alster
Multiple studies have analyzed the possible correlations between diabetes and Alzheimer's disease. Less is known about the context of cognitive deterioration among patients with atypical Parkinsonian syndromes and glucose metabolism impairment. The aim of this study was to evaluate the association between the impaired glucose metabolism and cognitive decline among patients with progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). The study included 22 patients with PSP and CBS with disease durations varying from 3 to 6 years...
January 14, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38250156/loss-of-mtx2-causes-mitochondrial-dysfunction-podocyte-injury-nephrotic-proteinuria-and-glomerulopathy-in-mice-and-patients
#29
JOURNAL ARTICLE
Ting Li, Ying Bao, Yu Xia, Hanyan Meng, Chao Zhou, Limin Huang, Xiaowen Wang, En Yin Lai, Pingping Jiang, Jianhua Mao
Proteinuria is a common and important clinical manifestation of chronic kidney disease (CKD) and an independent risk factor for the progression of kidney disease. As a component of the glomerular filtration barrier (GFB), podocyte plays a key role in the pathogenesis of glomerular diseases and proteinuria. However, the pathophysiology of glomerular diseases associated with mitochondrial function is incompletely understood. Here, we identified three novel mutations in MTX2 , encoding a membrane protein in mitochondria, associated with multisystem manifestations including nephrotic proteinuria and kidney injury in two Chinese patients...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38248790/association-between-relative-thrombocytosis-and-microalbuminuria-in-adults-with-mild-fasting-hyperglycemia
#30
JOURNAL ARTICLE
Jong Wook Choi, Tae Hoon Kim, Joon-Sung Park, Chang Hwa Lee
An elevated platelet count may contribute to significant thrombotic events and pose a risk for diabetic microvascular complications. Albuminuria, one of the hallmarks of diabetes, is thought to be a risk factor for endothelial dysfunction. In this study, we investigated the association between relative thrombocytosis and an increased urine albumin-to-creatinine ratio in healthy adult participants. Using multivariate analyses on data from the Korea National Health and Nutrition Examination Survey V-VI, 12,525 eligible native Koreans aged ≥ 20 were categorized into platelet count quintiles by sex...
January 12, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38246019/association-of-normal-and-mutated-apol1-g2-rs60910145-alleles-with-scd-body-mass-index-and-renal-function-biomarkers-and-indices
#31
JOURNAL ARTICLE
Abazar Mahmoud Ismail, Bakri Mohammed Nour, Adam Dawoud Abakar, Babiker Saad Almugadam, Hisham N Altayb, Rania TagEsir Ahmed, Mubarak Elsaeed Mustafa Elkarsany
PURPOSE OF THE STUDY: The current study aimed to detect the frequency of normal and mutated APOL1 alleles in sickle cell disease (SCD) patients and test their relation with Microalbuminuria, Creatinine, Urea, Glomerular Filtration Rate (GFR), and Body Mass Index (BMI). PATIENTS AND METHODS: The study included 156 SCD subjects. Serum Creatinine (mg/dl) and Urea (mg/dl) as well as Microalbuminuria (mg/l) level were measured by using Biosystems kit (Biosystems, Barcelona, Spain) and Mindary BA88A semi-automated biochemistry analyzer...
September 29, 2023: Current Research in Translational Medicine
https://read.qxmd.com/read/38244221/quantitative-assessment-of-early-kidney-injury-using-high-frame-rate-contrast-enhanced-ultrasonography-in-a-rabbit-model-of-diabetic-nephropathy
#32
JOURNAL ARTICLE
Fengrong Yang, Lei Jiang, Yue Ma, Yadong He, Yuqing Xu, Ru Yang, Banban Wu, Yang Li
AIM: To explore benefits of high-frame-rate contrast-enhanced ultrasonography (H-CEUS) for early kidney injury in a rabbit model of diabetic nephropathy (DN). METHODS: Diabetic rabbits were induced with alloxan administration and split into 2 groups with or without urinary microalbuminuria after a fatty and sugary diet: diabetic rabbits with nephropathy (Group A) and diabetic rabbits without nephropathy (Group B). The control group (Group C) comprised healthy rabbits...
January 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38240854/early-impact-of-albuminuria-on-cardiac-function-in-patients-with-chronic-kidney-disease-a-prospective-study
#33
JOURNAL ARTICLE
Yiming Li, Yongzhan Liu, Lili Gao, Chuan Tian
Cardiovascular disease (CVD) is the leading cause of end-stage mortality in chronic kidney disease (CKD) patients. However, CVD and CKD are inextricably linked, as microalbuminuria is an independent risk factor for CVD. Herein, we investigated changes in cardiac function and its risk factors in CKD patients who had different urine albumin-to-creatinine ratios (UACRs) and estimated glomerular filtration rates (eGFRs). We prospectively enrolled 182 CKD patients, classified into three groups based on UACRs and eGFRs...
January 19, 2024: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/38229469/risk-factor-control-and-incident-cardiovascular-disease-in-patients-with-diabetes-sex-specific-relations
#34
JOURNAL ARTICLE
Xuan Wang, Hao Ma, Xiang Li, Zhaoxia Liang, Vivian Fonseca, Lu Qi
AIM: Women with diabetes are at higher risk of cardiovascular diseases (CVD) than men with diabetes; however, the sex difference in the association between the degree of risk factor control and the risk of CVD in patients with diabetes is unclear. METHODS: In total, 17 260 participants diagnosed with diabetes from the UK Biobank were included and matched with 86 300 non-diabetes controls based on age, sex and assessment centre. The main exposure was the number of risk factors within the target range, including glycated haemoglobin level <53 mol/mol (7%), blood pressure <140/90 mm/Hg, low-density lipoprotein cholesterol <100 mg/dl, non-current smoking and absence of microalbuminuria...
January 16, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38223704/qiditangshen-granules-alleviates-diabetic-nephropathy-podocyte-injury-a-network-pharmacology-study-and-experimental-validation-in-vivo-and-vitro
#35
JOURNAL ARTICLE
Fei Gao, Ying Zhou, Borui Yu, Huidi Xie, Yang Shi, Xianhui Zhang, Hongfang Liu
BACKGROUND: QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration. METHODS: According to the active ingredients and targets of the QDTS in the TCMSP database, the network pharmacology of QDTS was investigated. The potential active ingredients were chosen based on the oral bioavailability and the drug similarity index...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38222779/relationship-between-gckr-gene-rs780094-polymorphism-and-type-2-diabetes-with-albuminuria
#36
Yi-Ying Liu, Qin Wan
BACKGROUND: Diabetic kidney disease is one of the common complications of type 2 diabetes (T2D). There are no typical symptoms in the early stage, and the disease will progress to moderate and late stage when albuminuria reaches a high level. Treatment is difficult and the prognosis is poor. At present, the pathogenesis of diabetic kidney disease is still unclear, and it is believed that it is associated with genetic and environmental factors. AIM: To explore the relationship between the glucokinase regulatory protein ( GCKR ) gene rs780094 polymorphism and T2D with albuminuria...
December 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/38197421/genetic-association-study-of-tert-gene-variants-with-chronic-kidney-disease-susceptibility-in-the-chinese-population
#37
JOURNAL ARTICLE
Yan Su, Yuan Feng, Xinran Lin, Chunyang Ma, Jiali Wei
The incidence and mortality of chronic kidney disease (CKD) are increasing globally. Studies have demonstrated the significance of genetic risk factors in the progression of CKD. Telomerase reverse transcriptase ( TERT ) may be implicated in the development of CKD. This study aimed to investigate the correlation between TERT gene variants and susceptibility to CKD in the Chinese population. A total of 507 patients with CKD and 510 healthy controls were recruited for this case-control study. Four candidate loci were identified using the MassARRAY platform...
December 2024: Renal Failure
https://read.qxmd.com/read/38196045/effect-of-sleeve-gastrectomy-versus-one-anastomosis-gastric-bypass-on-postoperative-renal-function-and-the-urinary-monocyte-chemoattractant-protein-1-mcp-1-level
#38
JOURNAL ARTICLE
Shimaa Monir Elmamlook, Alaa Abd El-Aziz Sabry, Mohamad Elrefai, Ahmed Bahie Eldeen
INTRODUCTION: Bariatric surgery has been the most effective treatment modality for morbid obesity that reduces associated comorbidities and improves quality of life. This study aims at evaluating and comparing the impact of two types of bariatric surgery-laparoscopic sleeve gastrectomy (LSG) and one anastomosis gastric bypass (OAGB)-on renal functions and urinary monocyte chemoattractant protein-1 (MPC-1) levels in morbidly obese patients 3 months after surgery. METHODS: This is a prospective study of 40 morbidly obese patients who underwent bariatric surgery...
January 9, 2024: Obesity Surgery
https://read.qxmd.com/read/38195965/adolescent-kidney-outcomes-after-extremely-preterm-birth-and-neonatal-acute-kidney-injury-there-may-be-more-to-the-story
#39
JOURNAL ARTICLE
Ryan Lupo, Emily Chang, Erica C Bjornstad, T Michael O'Shea, Keia R Sanderson
OBJECTIVE:  Among children born extremely preterm (EP), the antecedents of chronic kidney disease (CKD), including neonatal acute kidney injury (nAKI), are not well characterized. STUDY DESIGN:  This was a retrospective cohort pilot study. Participants ( n  = 36) were adolescents born before 28 weeks of gestation enrolled at birth into the extremely low gestational age newborn study, between 2002 and 2004, at the University of North Carolina...
January 9, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38191429/a-comparative-study-of-cardiovascular-risk-stratification-methods-in-type-1-diabetes-mellitus-patients
#40
JOURNAL ARTICLE
Fabiano Malard de Araujo, Fábio Vasconcellos Comim, Rodrigo N Lamounier, Natália F Pena, Virgínia C Fajardo, Regina Bicalho G de Faria, Yuri M Silva, Márcio Weissheimer Lauria
The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM).The current study investigated the agreement between ST1RE and the Brazilian Society for Endocrinology and Metabology (SBEM) classification. Participants were included in the study if diagnosed with T1DM and had at least one outpatient visit in 2021...
January 9, 2024: Diabetology & Metabolic Syndrome
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