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Microalbuminuria

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https://www.readbyqxmd.com/read/28811763/microalbuminuria-in-type-2-diabetes-mellitus-the-tip-of-iceberg-of-diabetic-complications
#1
Tauseef Ahmad, Imran Ulhaq, Minaz Mawani, Najmul Islam
OBJECTIVE: To determine the prevalence of microalbuminuria and its association with hypertension and other diabetic complications among Type-2 diabetic patients attending at Aga Khan University Hospital Karachi. METHODS: 1280 Type-2 diabetes patients who visited the outpatient department of Aga Khan University Hospital from September 2014 to August 2016 were included in the study. Microalbuminuria was diagnosed if spot urinary microalbumin excretion was confirmed to be more than 20mg/l...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28794898/a-multicenter-cohort-study-of-primary-hypertension-in-korea-study-design-and-interim-analysis-of-the-korean-registry-of-target-organ-damage-in-hypertension-korhr
#2
Suk-Won Choi, Seong Woo Han, Jong Sun Ok, Byung-Su Yoo, Mi-Seung Shin, Sung Ha Park, Kyu-Hyung Ryu
BACKGROUND: The Korean Registry of Target Organ Damage in Hypertension aims to evaluate the clinical characteristics and prevalence of subclinical target organ damage in Korean hypertensive patients. METHOD: This is a prospective, observational, multicenter cohort study in which 23 university hospitals participated. Since May 2013, we have enrolled 1,318 consecutive hypertensive patients without known cardiovascular disease who met the following inclusion criteria: 1) age older than 30 years and 2) the first visit to the participating hospitals was within the last 5 years...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28793022/kidney-involvement-in-malaria-an-update
#3
Geraldo Bezerra da Silva, José Reginaldo Pinto, Elvino José Guardão Barros, Geysa Maria Nogueira Farias, Elizabeth De Francesco Daher
Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28792141/validation-of-a-newly-developed-equation-for-estimating-serum-apolipoprotein-b-associations-with-cardiovascular-disease-surrogate-markers-in-koreans
#4
Jong Dai Kim, You Cheol Hwang, Hong Yup Ahn, Cheol Young Park
PURPOSE: Many clinical guidelines recommend apolipoprotein B (apoB) measurement, particularly in subjects with metabolic syndrome or type 2 diabetes. Recently, we developed a new equation to estimate serum apoB (apoBE). We validated the clinical relevance of apoBE and compared the performance of the equation with conventional lipid measurements and direct measurement of apoB. MATERIALS AND METHODS: Study subjects were recruited from patients who visited the Health Screening Center at Kangbuk Samsung Hospital between January and December 2009 for routine medical examinations (n=78125)...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28769803/lovastatin-alleviates-endothelial-to-mesenchymal-transition-in-glomeruli-via-suppression-of-oxidative-stress-and-tgf-%C3%AE-1-signaling
#5
Zejun Ma, Lili Zhu, Yan Liu, Zhida Wang, Yang Yang, Liming Chen, Qiulun Lu
Statins may decrease chronic kidney diseases (CKDs) risk, but their underlying molecular mechanisms are not completely understood. Recent studies indicate Endothelial-to-mesenchymal transition (EndMT) plays an important role contributing to renal interstitial fibrosis. In the present study, we first investigated whether lovastatin could ameliorate renal fibrosis via suppression of EndMT and its possible mechanism. In vitro experiments, lovastatin significantly ameliorated microalbuminuria and pathologic changes in diabetic rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28768285/prevention-of-diabetic-nephropathy-by-modified-acidic-fibroblast-growth-factor
#6
Ana M Pena, Shali Chen, Biao Feng, Lu Cai, Xiaokun Li, Guang Liang, Subrata Chakrabarti
BACKGROUND/AIMS: Oxidative stress (OS) contributes to all chronic diabetic complications, including diabetic nephropathy (DN). Acidic fibroblast growth factor (aFGF) has shown to confer protection from OS. However, it also has potent angiogenic activity. We hypothesized that a modified human aFGF (maFGF), with antioxidant properties but devoid of angiogenic activity, has preventative action in DN. METHODS: Streptozotocin-induced diabetic mice were treated with maFGF (intraperitoneally) daily for 1 or 6 months and were compared with untreated diabetic and non-diabetic controls...
July 29, 2017: Nephron
https://www.readbyqxmd.com/read/28763896/-association-between-serum-uric-acid-levels-and-high-sensitive-c-reactive-protein-in-patients-with-type-2-diabetes
#7
Z Y Li, B Liu, Y Ji, X J Zhuang, Y D Shen, H R Tian, L X Li, F Liu
Objective: To investigate the relationship between serum uric acid (SUA) levels and high sensitive C-reactive protein (hs-CRP) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 400 patients who were hospitalized in the Department of Endocrinology and Metabolism of Jinshan Branch, Shanghai Sixth People's Hospital between April 2014 and December 2015 were divided into normouricemia (NUA, n=319) group and hyperuricemia (HUA, n=81) group according to the presence of HUA. Clinical features of the two groups were compared...
July 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28762685/fabry-disease-in-southern-sardinia-epidemiological-results-from-screening-in-an-extensive-area
#8
Piergiorgio Bolasco, Irene Sitzia, Stefano Murtas
Introduction: Epidemiological data relating to the prevalence and incidence of Fabry disease (FD) and other Lysosomal Storage diseases (LSDs) are largely underestimated and not yet well known. Distribution of the disease varies according to geographical area and to ethnic origin. Heterozygous females are also at risk of contracting severe and multi-symptomatic forms of FD. Aim: To demonstrate the results obtained in outpatient surgeries situated in an area comprising 319,340 inhabitants...
August 1, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28754557/accelerated-podocyte-detachment-and-progressive%C3%A2-podocyte-loss-from-glomeruli-with%C3%A2-age%C3%A2-in-alport-syndrome
#9
Fangrui Ding, Larysa Wickman, Su Q Wang, Yanqin Zhang, Fang Wang, Farsad Afshinnia, Jeffrey Hodgin, Jie Ding, Roger C Wiggins
Podocyte depletion is a common mechanism driving progression in glomerular diseases. Alport Syndrome glomerulopathy, caused by defective α3α4α5 (IV) collagen heterotrimer production by podocytes, is associated with an increased rate of podocyte detachment detectable in urine and reduced glomerular podocyte number suggesting that defective podocyte adherence to the glomerular basement membrane might play a role in driving progression. Here a genetically phenotyped Alport Syndrome cohort of 95 individuals [urine study] and 41 archived biopsies [biopsy study] were used to test this hypothesis...
July 26, 2017: Kidney International
https://www.readbyqxmd.com/read/28754089/predictive-factors-and-prevalence-of-microalbuminuria-in-hiv-infected-patients-a-cross-sectional-analysis
#10
Katia Falasca, Marta Di Nicola, Italo Porfilio, Claudio Ucciferri, Elisabetta Schiaroli, Chiara Gabrielli, Daniela Francisci, Jacopo Vecchiet
BACKGROUND: Renal dysfunction is a common problem in the HIV+ population, due to the effect of both the HIV virus and the several classes of ARV drugs such as tenofovir (TDF). It is also known that the presence of renal damage correlates with cardiovascular risk and therefore with the risk of mortality of the patients accordingly. The detection of early renal damage is very important. Albuminuria and microalbuminuria are markers of early kidney disease and cardiovascular risk. The aim of the study is to evaluate the prevalence of microalbuminuria in a large polycentric sample, of unselected and consecutive HIV-patients followed as outpatients, and to assess its association with different therapeutic regimens...
July 28, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28748876/end-stage-renal-disease-in-patients-with-sickle-cell-disease
#11
Ahmed M Alkhunaizi, Adil A Al-Khatti, Samir H Al-Mueilo, Abdulrazack Amir, Bedri Yousif
Sickle cell nephropathy is a severe complication of sickle cell disease (SCD) that has a wide range of manifestations, from asymptomatic microalbuminuria to end-stage renal disease (ESRD). The data on patients with SCD who develop ESRD are scarce. The aim of this study was to explore the course of patients with SCD who developed ESRD and received renal replacement therapy (RRT). The course of patients with SCD who developed ESRD and started dialysis at two centers in the Eastern Province of Saudi Arabia was retrospectively analyzed...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28727675/type-1-diabetes-mellitus-caused-by-treatment-with-low-dose-interferon-%C3%AE-in-a-melanoma-patient
#12
Daniel Sossau, Lukas Kofler, Thomas Eigentler
Interferon-α (INF-α) is used as an adjuvant treatment for high-risk cutaneous melanoma. It has a large variety of potentially severe and irreversible side effects and can contribute toward the development of autoimmune disease. We report a case of a 59-year-old woman who developed type 1 diabetes following the use of low-dose IFN-α for the adjuvant treatment of stage IIB melanoma. Fifteen months after initiating IFN-α, she presented with blood glucose of 1126 mg/dl, hyponatremia, and microalbuminuria...
July 19, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28723880/prevalence-and-clinical-characteristics-of-white-coat-hypertension-based-on-different-definition-criteria-in-untreated-and-treated-patients
#13
Alejandro de la Sierra, Ernest Vinyoles, José R Banegas, Julián Segura, Manuel Gorostidi, Juan J de la Cruz, Luis M Ruilope
BACKGROUND AND AIM: The prevalence and associated risks of white-coat hypertension (WCH) are still a matter of debate. We aimed to assess differences in prevalence and associated conditions of WCH defined on the basis of the normality of all daytime, night-time, and 24-h blood pressure (BP), only daytime, or only 24-h BP. METHODS: We selected 115 708 patients (45 020 untreated and 70 688 treated) from the Spanish Ambulatory BP Monitoring Registry. WCH was estimated in patients with elevated office BP (≥140 and/or 90 mmHg) by using normal daytime (<135/85) BP, normal 24-h BP (<130/80), or normal daytime, night-time (<120/70) and 24-h BP...
July 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28721700/blood-pressure-lowering-efficacy-of-indapamide-sr-amlodipine-combination-in-older-patients-with-hypertension-a-post-hoc-analysis-of-the-nestor-trial-natrilix-sr-vs-enalapril-in-hypertensive-type-2-diabetics-with-microalbuminuria
#14
Olivier Hanon, Laure Caillard, Edouard Chaussade, Intza Hernandorena, Clemence Boully
To examine the antihypertensive efficacy and safety of indapamide sustained-release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted. NESTOR randomized 570 patients (n=197, aged ≥65 years) with hypertension (systolic BP 140-180/diastolic BP <110 mm Hg) to indapamide SR 1.5 mg or enalapril 10 mg...
July 18, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28721497/normoalbuminuric-diabetic-kidney-disease
#15
REVIEW
Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun
Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD). Early diagnosis is very important in preventing the development of DKD. Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD, and microalbuminuria has been recommended as the first clinical sign of DKD. The natural history of DKD has been divided into three stages: normoalbuminuria, microalbuminuria, and macroalbuminuria...
July 18, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28719154/progression-of-skin-autofluorescence-of-ages-over-4-years-in-patients-with-type-1-diabetes
#16
Kalina Rajaobelina, Catherine Helmer, Fritz-Line Vélayoudom-Céphise, Sovanndany Nov, Blandine Farges, Emilie Pupier, Laurence Blanco, Marie Hugo, Henri Gin, Vincent Rigalleau
BACKGROUND: The deposit of Advanced Glycation End-products (AGEs) is involved in diabetic complications. It can be evaluated by measuring the skin autofluorescence (sAF). We searched whether sAF progressed over 4 years in Type 1 Diabetes, and analysed its relationship with the development of nephropathy. METHODS: Two measurements of sAF was realized on 154 patients during years 2009 and 2013. Baseline factors associated to the progression of sAF were analyzed by multivariate regression analysis...
July 18, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28716801/diabetes-mellitus-microalbuminuria-and-subclinical-cardiac-disease-identification-and-monitoring-of-individuals-at-risk-of-heart-failure
#17
Peter P Swoboda, Adam K McDiarmid, Bara Erhayiem, David P Ripley, Laura E Dobson, Pankaj Garg, Tarique A Musa, Klaus K Witte, Mark T Kearney, Julian H Barth, Ramzi Ajjan, John P Greenwood, Sven Plein
BACKGROUND: Patients with type 2 diabetes mellitus and elevated urinary albumin:creatinine ratio (ACR) have increased risk of heart failure. We hypothesized this was because of cardiac tissue changes rather than silent coronary artery disease. METHODS AND RESULTS: In a case-controlled observational study 130 subjects including 50 ACR+ve diabetes mellitus patients with persistent microalbuminuria (ACR >2.5 mg/mol in males and >3.5 mg/mol in females, ≥2 measurements, no previous renin-angiotensin-aldosterone therapy, 50 ACR-ve diabetes mellitus patients and 30 controls underwent cardiovascular magnetic resonance for investigation of myocardial fibrosis, ischemia and infarction, and echocardiography...
July 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28715448/effect-of-synergistic-interaction-between-abnormal-adiposity-related-metabolism-and-prediabetes-on-microalbuminuria-in-the-general-population
#18
Jong Wook Choi, Il Hwan Oh, Chang Hwa Lee, Joon-Sung Park
Central obesity and related metabolic components are important risks for microalbuminuria. To describe the effects of interactions between central obesity and related metabolic components on microalbuminuria, we conducted a nation-wide, population-based interaction analysis using cardio-metabolic index (CMI) as a candidate indicator of central obesity and related abnormal lipid metabolism. We recruited native Koreans aged 20 years or older with no medical illness. A total of 5398 participants were divided into quintiles according to CMI with sex as a covariate factor...
2017: PloS One
https://www.readbyqxmd.com/read/28710207/comorbidities-complications-and-mortality-in-people-of-south-asian-ethnicity-with-type-1-diabetes-compared-with-other-ethnic-groups-a-systematic-review
#19
Komil N Sarwar, Phoebe Cliff, Ponnusamy Saravanan, Kamlesh Khunti, Krishnarajah Nirantharakumar, Parth Narendran
OBJECTIVE: The aim of this systematic review is to explore the association of South Asian (SA) ethnicity on comorbidities, microvascular and macrovascular complications and mortality compared with other ethnic groups in people with type 1 diabetes mellitus (T1DM). DESIGN: Systematic review. METHOD: A systematic literature search strategy was designed and carried out using Medline and Embase for full-text and abstract studies published in English from 1946 to February 2016...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28701152/performance-of-urinary-neutrophil-gelatinase-associated-lipocalin-clusterin-and-cystatin-c-in-predicting-diabetic-kidney-disease-and-diabetic-microalbuminuria-a-consecutive-cohort-study
#20
Xian-Fei Zeng, Dong-Xue Lu, Jun-Min Li, Yun Tan, Zhuo Li, Lei Zhou, Zeng-Qian Xi, Shu-Miao Zhang, Wei Duan
BACKGROUND: Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urinary neutrophil gelatinase-associated lipocalin [NGAL], clusterin, and cystatin C) for DKD and diabetic microalbuminuria, and whether or not the tubular biomarkers appear earlier than microalbuminuria. METHODS: In this consecutive cohort study, 146 type 2 diabetes mellitus (T2DM) patients with a disease duration of ≥6 years were enrolled...
July 12, 2017: BMC Nephrology
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