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Microalbuminuria

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https://www.readbyqxmd.com/read/28513288/growth-arrest-specific-protein-6-gas6-as-a-noninvasive-biomarker-for-early-detection-of-diabetic-nephropathy
#1
Wenni Li, Junlin Wang, Lina Ge, Jiehui Shan, Chunbing Zhang, Jianping Liu
BACKGROUND: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). METHODS: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. RESULTS: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher...
May 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28503768/the-contribution-of-cardio-metabolic-risk-factors-to-estimated-glomerular-filtration-rate-egfr-decline-in-indigenous-australians-with-and-without-albuminuria-the-egfr-follow-up-study
#2
Elizabeth Barr, Federica Barzi, Jaquelyne T Hughes, George Jerums, Kerin O'Dea, Alex Brown, Elif I Ekinci, Graham Rd Jones, Paul D Lawton, Ashim Sinha, Richard J MacIsaac, Alan Cass, Louise J Maple-Brown
BACKGROUND: Risk factors for estimated glomerular filtration rate (eGFR) decline beyond albuminuria are not fully understood in Indigenous Australians who have a 6-fold risk of end-stage kidney disease. We assessed associations between cardio-metabolic risk factors and eGFR decline according to baseline albuminuria status to identify potential treatment targets. METHODS: The eGFR Follow-up study is a longitudinal cohort of 520 Indigenous Australians. Linear mixed regression was used to estimate associations between baseline cardio-metabolic risk factors and annual Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR change (ml/min/1...
May 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28501343/changes-of-renal-sinus-fat-and-renal-parenchymal-fat-during-an-18-month-randomized-weight-loss-trial
#3
Hila Zelicha, Dan Schwarzfuchs, Ilan Shelef, Yftach Gepner, Gal Tsaban, Lilac Tene, Anat Yaskolka Meir, Avital Bilitzky, Oded Komy, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusi, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Yosef S Haviv, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND & AIMS: Data regarding the role of kidney adiposity, its clinical implications, and its dynamics during weight-loss are sparse. We investigated the effect of long-term weight-loss induced intervention diets on dynamics of renal-sinus-fat, an ectopic fat depot, and %renal-parenchymal-fat, lipid accumulation within the renal parenchyma. METHODS: We randomized 278 participants with abdominal obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets, with or without exercise...
May 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28497441/-cryptogenic-stroke-in-a-young-patient-with-heart-disease-and-kidney-failure
#4
B Oyanguren, R Segoviano, E Alegria, E Besada, M Gonzalez-Salaices, M Eimil-Ortiz, C Lopez de Silanes
INTRODUCTION: Fabry's disease is an infrequent metabolic pathology linked to the X chromosome which causes a wide variety of signs and symptoms. CASE REPORT: A 39-year-old male who was admitted to our stroke unit with right-side hemiparesis (1 + 0) and dysarthria (1). The score on the National Institute of Health Stroke Scale was 2. The patient presented angiokeratomas in both thighs. A computerised axial tomography scan of the head showed left thalamic acute infarction...
May 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28496313/relationships-of-pancreatic-beta-cell-function-with-microalbuminuria-and-glomerular-filtration-rate-in-middle-aged-and-elderly-population-without-type-2-diabetes-mellitus-a-chinese-community-based-analysis
#5
Shihui Fu, Shanjing Zhou, Leiming Luo, Ping Ye
BACKGROUND: Relationships of pancreatic beta-cell function abnormality with microalbuminuria (MA) and glomerular filtration rate (GFR) may differ by age, ethnicity and accompanied diseases. Previous studies were generally conducted in Western adult patients with type 2 diabetes mellitus (T2DM), and it is uncertain whether pancreatic beta-cell function is associated with MA and GFR in Chinese community-dwelling middle-aged and elderly population without T2DM. We therefore examined the relationships of pancreatic beta-cell function with two indices of renal damage, MA and GFR, in Chinese community-dwelling middle-aged and elderly population without T2DM...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28494191/biomarker-for-early-renal-microvascular-and-diabetic-kidney-diseases
#6
Narisa Futrakul, Prasit Futrakul
Recognition of early stage of diabetic kidney disease, under common practice using biomarkers, namely microalbuminuria, serum creatinine level above 1 mg/dL and accepted definition of diabetic kidney disease associated with creatinine clearance value below 60 mL/min/1.73 m(2), is unlikely. This would lead to delay treatment associated with therapeutic resistance to vasodilator due to a defective vascular homoeostasis. Other alternative biomarkers related to the state of microalbuminuria is not sensitive to screen for early diabetic kidney disease (stages I, II)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28482676/skin-microvascular-endothelial-dysfunction-is-associated-with-type-2-diabetes-independently-of-microalbuminuria-and-arterial-stiffness
#7
Hanna Jonasson, Sara Bergstrand, Fredrik H Nystrom, Toste Länne, Carl Johan Östgren, Niclas Bjarnegård, Ingemar Fredriksson, Marcus Larsson, Tomas Strömberg
Skin and kidney microvascular functions may be affected independently in diabetes mellitus. We investigated skin microcirculatory function in 79 subjects with diabetes type 2, where 41 had microalbuminuria and 38 not, and in 41 age-matched controls. The oxygen saturation, fraction of red blood cells and speed-resolved microcirculatory perfusion (% red blood cells × mm/s) divided into three speed regions: 0-1, 1-10 and above 10 mm/s, were assessed during baseline and after local heating of the foot with a new device integrating diffuse reflectance spectroscopy and laser Doppler flowmetry...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28481608/risk-factors-for-diabetic-retinopathy-among-homeless-veterans
#8
John A Davis, Irena Tsui, Lillian Gelberg, Sonya Gabrielian, Martin L Lee, Evelyn T Chang
Homeless patients have high rates of visual impairment and lower rates of glycemic control than housed patients. Although diabetic retinopathy (DR) is the most common cause of new visual impairment and legal blindness in the developed world, little is known about differential risk factors for and rates of DR in homeless versus housed populations. This study aimed to compare the rates of DR between homeless and housed patients with diabetes at the Greater Los Angeles Veterans Affairs Health care System (GLA) and identify clinical and psychosocial predictors of DR rates...
May 2017: Psychological Services
https://www.readbyqxmd.com/read/28475170/urinary-tract-infections-in-postmenopausal-women-with-type-2-diabetes-clinical-correlates-and-quinolone-susceptibility
#9
Martyna Borowczyk, Anna Chmielarz-Czarnocińska, Paula Faner, Andrzej Paciorkowski, Jan K Nowak, Ewelina Szczepanek-Parulska, Marek Ruchała, Maciej Cymerys
INTRODUCTION    Both diabetes mellitus and the postmenopausal period predispose to urinary tract infections (UTIs). However, the data on UTIs in postmenopausal diabetics are scarce.  OBJECTIVES    The aim was to determine the prevalence of UTIs in postmenopausal women with type 2 DM (T2DM), identify the potential risk factors, describe the causative pathogens, and assess their susceptibility to quinolones. PATIENTS AND METHODS    The patients were interviewed, examined, and had their hospital records analyzed...
May 5, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28473191/anemia-in-diabetes-experience-of-a-single-treatment-center-in-kuwait
#10
Faisal Alsayegh, Mohammad Waheedi, Tania Bayoud, Asma Al Hubail, Faisal Al-Refaei, Prem Sharma
AIMS: Diabetes mellitus is the most common metabolic disorder in Kuwait. Anemia is a known outcome of diabetes and its related complications. This study examined the prevalence of anemia in diabetic subjects in Kuwait as well as any association between the presence of anemia with Hemoglobin A1c and diabetes complications. METHODS: The study subjects were diabetic patients with complete records and two or more visits at Dasman Diabetes Institute. Patient's data included demographics, complications, medications and laboratory results...
May 1, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28459597/association-of-urinary-activity-of-mmp-2-with-microalbuminuria-in-an-isolated-sample-of-subjects-living-in-high-altitude-rural-locations-in-m%C3%A3-xico
#11
Magda Elena Hernández-Hernández, Jaime Morales-Romero, Clara Luz Sampieri, Diego Jesús Luna Lozano, Isidra Del Carmen Valencia Lezama, Mónica Janett Muñoz Contreras, Arturo Rodríguez Hernández
Hernández-Hernández, Magda Elena, Jaime Morales-Romero, Clara Luz Sampieri, Diego Jesús Luna Lozano, Isidra del Carmen Valencia Lezama, Mónica Janett Muñoz Contreras, and Arturo Rodríguez Hernández. Association of urinary activity of MMP-2 with microalbuminuria in an isolated sample of subjects living in high altitude rural locations in México. High Alt Med Biol. 00:000-000, 2017.-Matrix metalloproteinases (MMP) are implicated in remodeling of the renal extracellular matrix. In a cross-sectional study we evaluated renal impairment in general population of high-altitude rural locations in México...
May 1, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28453363/a-polyphenol-based-multicomponent-nutraceutical-in-dysmetabolism-and-oxidative-stress-results-from-a-pilot-study
#12
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
To assess short-term efficacy and safety of a multicomponent nutraceutical (MCN) on dysmetabolism and oxidative stress, a pilot prospective observational study was performed on 21 individuals (12 men and 9 women) who took, for 60 days, 2 tablets per day of an MCN based on antioxidants and metabolism regulators: hydroxytyrosol (15 mg), maqui (300 mg), amla (200 mg), monacolin K (10 mg), berberine (245 mg), astaxanthin (0.5 mg), coenzyme Q10 (100 mg), and folic acid (200 mcg). On day 0 (T0) and day 60 (T60), all participants underwent laboratory tests related to lipid profile, carbohydrate metabolism, oxidative stress, and cellular inflammation...
April 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28452212/the-prevalence-of-hypertension-in-children-with-renal-scars
#13
Nakysa Hooman, Roya Isa-Tafreshi, Seyed-Hassan Mostafavi, Farideh Hallaji, Azita Tavasoli, Hasan Otukesh
BACKGROUND: Hypertension (HTN) is a late outcome of congenital or acquired renal scar. We used ambulatory blood pressure to assess the early blood pressure abnormalities in children with history of urinary tract infection with various degrees of renal scars. METHODS: Between 2009 and 2011, 60 (45 females, 15 males) children aged 5-15 years and height equal or more than 120 cm with previous history of febrile urinary tract infection were entered into the study. All children went on 24-hour ambulatory blood pressure monitoring (24-H ABPM)...
June 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28438853/factors-associated-with-microalbuminuria-remission-in-patients-with-type-2-diabetes-importance-of-early-intervention-for-microalbuminuric-patients-tsugaru-study
#14
REVIEW
Norio Nakamura, Ikuyo Narita, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Masayuki Nakamura, Hiroshi Osawa, Hideaki Yamabe, Ken Okumura
AIM: The aim of this study was to clarify the rates of remission and progression for microalbuminuria in patients with type 2 diabetes (T2DM); and factors associated with remission and progression of diabetic nephropathy (DN). PATIENTS AND METHODS: T2DM patients with a urinary albumin excretion (UAE) rate of 30-300 mg/gCr who were attending the medical clinic in the Tsugaru region in Japan were enrolled into this prospective, observational study for 36 months (N=317)...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438309/association-of-albuminuria-with-cardiac-dysfunction-in-us-hispanics-latinos
#15
David B Hanna, Shuo Xu, Michal L Melamed, Franklyn Gonzalez, Matthew A Allison, Martin S Bilsker, Barry E Hurwitz, Mayank M Kansal, Neil Schneiderman, Sanjiv J Shah, Robert C Kaplan, Carlos J Rodriguez, Jorge R Kizer
Higher urine albumin-to-creatinine ratio (UACR) has been associated with cardiac dysfunction in the general population. We assessed the association of UACR with cardiac structure and function in the Echocardiographic Study of Latinos (Echo-SOL), an ancillary study of the Hispanic Community Health Study/Study of Latinos across 4 US sites. Echo-SOL participants underwent standard 2-dimensional echocardiography, including speckle-tracking strain analysis. UACR was categorized as normal and high-normal (based on the midpoint of values below microalbuminuria), microalbuminuria (≥17 mg/g for men; ≥25 mg/g for women), and macroalbuminuria (≥250 mg/g; ≥355 mg/g)...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28437814/assessment-of-early-cardiovascular-risk-in-children-and-adolescents-with-essential-hypertension
#16
Andreja Stelcar, Evgenija Homsak, Natasa Marcun Varda
The aim of our study was to investigate some early markers of hypertensive target organ damage in hypertensive children and adolescents, and to detect those showing most prominent clinical significance. We included 100 children with essential hypertension (EH) and 50 age-matched healthy control children, and evaluated left ventricular mass (LVM), intima-media thickness in the carotid arteries (IMT), pulse wave velocity (PWV), microalbuminuria, biochemical parameters and some adipokines. Statistically significant differences between the 2 groups were observed for HDL-cholesterol, LDL-cholesterol, triglycerides, insulin, uric acid, glucose, apolipoprotein A1, and total adiponectin...
April 24, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28432895/predictive-ability-of-visit-to-visit-variability-in-hba1c-and-systolic-blood-pressure-for-the-development-of-microalbuminuria-and-retinopathy-in-people-with-type-2-diabetes
#17
Toshiko Takao, Machi Suka, Hiroyuki Yanagisawa, Yutaka Matsuyama, Yasuhiko Iwamoto
AIMS: We explored whether visit-to-visit variability in both glycated hemoglobin (HbA1c) and systolic blood pressure (SBP) simultaneously predicted the development of microalbuminuria and retinopathy, and whether the predictive ability of these measurements changed according to mean HbA1c and SBP levels in people with type 2 diabetes. METHODS: A retrospective observational cohort study was conducted on 243 type 2 diabetes patients with normoalbuminuria and 486 without retinopathy at the first visit and within 1year thereafter...
April 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28421206/the-increased-circulating-plasma-levels-of-vascular-endothelial-growth-factor-in-patients-with-type-1-diabetes-do-not-correlate-to-metabolic-control
#18
Kailash Singh, Stellan Sandler, Daniel Espes
Aim. To characterize the plasma levels of vascular endothelial growth factor (VEGF) in type 1 diabetes mellitus (T1D) and its relation to both present and historical metabolic control and microvascular complications. Methods. Plasma levels of VEGF and routine clinical parameters were analyzed in 115 patients with long-standing T1D and 45 healthy controls (HC). All patients were under clinical routine diabetes treatment at Uppsala University Hospital. Results. The plasma levels of VEGF were increased by 37% in patients with T1D when compared to HC (18...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28407880/oellgaard-j-g%C3%A3-de-p-rossing-p-et%C3%A2-al-intensified-multifactorial-intervention-in-type-2-diabetics-with-microalbuminuria-leads-to-long-term-renal-benefits-kidney-int-2017-91-982-988
#19
https://www.readbyqxmd.com/read/28404658/association-of-glycemic-variability-in-type-1-diabetes-with-progression-of-microvascular-outcomes-in-the-diabetes-control-and-complications-trial
#20
John M Lachin, Ionut Bebu, Richard M Bergenstal, Rodica Pop-Busui, F John Service, Bernard Zinman, David M Nathan
OBJECTIVE: The Diabetes Control and Complications Trial (DCCT) demonstrated the beneficial effects of intensive versus conventional therapy on the development and progression of microvascular complications of type 1 diabetes. These beneficial effects were almost completely explained by the difference between groups in the levels of HbA1c, which in turn were associated with the risk of these complications. We assessed the association of glucose variability within and between quarterly 7-point glucose profiles with the development and progression of retinopathy, nephropathy, and cardiovascular autonomic neuropathy during the DCCT...
April 12, 2017: Diabetes Care
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