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Microalbuminuria

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https://www.readbyqxmd.com/read/28210839/thrombotic-microangiopathy-caused-by-methionine-synthase-deficiency-diagnosis-and-treatment-pitfalls
#1
Maria Helena Vaisbich, Andressa Braga, Maria Gabrielle, Clarissa Bueno, Flávia Piazzon, Fernando Kok
BACKGROUND: Inborn errors of cobalamin (Cbl) metabolism form a large group of rare diseases. One of these, Cbl deficiency type C (CblC), is a well-known cause of thrombotic microangiopathy (TMA), especially in infants. However, there has only been a single published case of TMA associated to Cbl deficiency type G (CblG), also known as methionine synthase deficiency (MSD). CASE DIAGNOSIS/TREATMENT: A 21-month-old boy presented with pallor and oral ulcers during episodes of upper respiratory infection (URI)...
February 16, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28201997/the-association-between-interleukin-19-concentration-and-diabetic-nephropathy
#2
Li Li, Xu-Gan Jiang, Juan-Yu Hu, ZHeng-Qing Yu, Jian-Yong Xu, Fan Liu, Guang-Chun Zhao, Lei Zhang, Hui-Ming Gu, Si-Jing Zhang, Jin Meng
BACKGROUND: Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to investigate the relation of serum interleukin-19 (IL-19) levels with diabetic nephropathy (DN). METHODS: Two hundred study groups of patients with type 2 diabetes mellitus (T2DM) (109 males and 91 females) were recruited, included normoalbuminuria(n = 102), microalbuminuria(n = 72) and macroalbuminuria(n = 26) ...
February 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28194484/perturbations-of-the-anti-ageing-hormone-klotho-in-patients-with-type-1-diabetes-and-microalbuminuria
#3
Giuseppe Maltese, Nikolaos Fountoulakis, Richard C Siow, Luigi Gnudi, Janaka Karalliedde
AIMS/HYPOTHESIS: Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown. METHODS: In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drugs)...
February 13, 2017: Diabetologia
https://www.readbyqxmd.com/read/28191534/the-relation-of-anthropometric-measurements-and-insulin-resistance-in-patients-with-polycystic-kidney-disease
#4
Bennur Esen, Emel Sağlam Gokmen, Mahmut Kaya, Burak Ozkan, Ahmet Engin Atay
OBJECTIVE: To examine the frequency of insulin resistance (IR) and its relation with anthropometric measurements in patients with autosomal dominant polycystic kidney disease (ADPKD). MATERIAL AND METHODS: Nonobese 82 patients with ADPKD and 58 age matched healthy controls were enrolled into the study. None of participants were diabetic or receiving renal replacement therapies (RRT). IR was determined by homeostasis model assessment of insulin resistance (HOMA-IR) formula...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28187983/intensified-multifactorial-intervention-in-type-2-diabetics-with-microalbuminuria-leads-to-long-term-renal-benefits
#5
Jens Oellgaard, Peter Gæde, Peter Rossing, Frederik Persson, Hans-Henrik Parving, Oluf Pedersen
In the present post hoc analyses we studied the impact of intensified, multifactorial treatment on renal outcomes in patients with type 2 diabetes and microalbuminuria enrolled in the Steno-2 Study. Outcome measures were progression to macroalbuminuria, decline in the glomerular filtration rate (GFR), and development of end stage renal disease (ESRD). In total, 160 patients with type 2 diabetes and microalbuminuria were recruited and assigned to conventional or intensified therapy targeting multiple risk factors...
February 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28184234/exploring-diurnal-variation-using-piecewise-linear-splines-an-example-using-blood-pressure
#6
Jamie M Madden, Xia Li, Patricia M Kearney, Kate Tilling, Anthony P Fitzgerald
BACKGROUND: There are many examples of physiological processes that follow a circadian cycle and researchers are interested in alternative methods to illustrate and quantify this diurnal variation. Circadian blood pressure (BP) deserves additional attention given uncertainty relating to the prognostic significance of BP variability in relation to cardiovascular disease. However, the majority of studies exploring variability in ambulatory blood pressure monitoring (ABPM) collapse the data into single readings ignoring the temporal nature of the data...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28182086/urinary-microvesicle-bound-uromodulin-a-potential-molecular-biomarker-in-diabetic-kidney-disease
#7
Neng-Jun Lou, Yi-Hong Ni, Hong-Ying Jia, Jing-Ti Deng, Lu Jiang, Feng-Jie Zheng, Ai-Li Sun
This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD). 31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study. The patients with T2DM were divided into three groups based on the urinary albumin/creatinine ratio (UACR): normoalbuminuria group (DM, n = 46); microalbuminuria group (DN1, n = 32); and macroalbuminuria group (DN2, n = 22)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28181108/circulating-levels-of-fibroblast-growth-factor-21-in-early-stage-diabetic-kidney-disease
#8
A Esteghamati, A Khandan, A Momeni, A Behdadnia, A Ghajar, M S Nikdad, S Noshad, M Nakhjavani, M Afarideh
AIMS/PURPOSE: Fibroblast growth factor 21 (FGF21), a hepatoadipokine with pleiotropic metabolic regulatory actions, is emerging as a novel biomarker of progressive nephropathy. We sought to evaluate circulating FGF21 and its association with clinical and biochemical characteristics as well as the urinary albumin excretion (UAE) rates in a population of patients with type 2 diabetes (T2D) with or without microalbuminuria and their matched healthy controls. METHODS: Cross-sectionally, 130 consecutive individuals comprising patients with T2D with (n = 44) or without (n = 44) microalbuminuria and their healthy controls (n = 42) were recruited for analysis...
February 8, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28176231/prevalence-of-asymptomatic-microalbuminuria-in-hiv-positive-children-in-india
#9
Gorav Sharma, Sheila S Mathai
OBJECTIVE: To study the prevalence of covert or early renal involvement among human immunodeficiency virus (HIV) positive children. METHODS: A cross-sectional observational study was carried out on 250 HIV positive children (2-18 y) on follow-up in a tertiary care hospital from January 2014 through June 2015. Those who met the study criteria were evaluated for microalbuminuria and glomerular and tubular dysfunctions. RESULTS: Fifty-one out of two hundred fifty (20%) children were found to have microalbuminuria though none had any other evidence of renal dysfunction...
February 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28166066/prevalence-of-sensory-neuropathy-in-type-2-diabetes-mellitus-and-its-correlation-with-duration-of-disease
#10
D B Karki, S K Yadava, S Pant, N Thusa, E Dangol, S Ghimire
Background Peripheral neuropathy is one of the most common and distressing late complication of diabetes mellitus. Ignorance of the complications may develop foot ulcers and gangrene requiring amputation. Objective The main objective of this study is to find out the prevalence of sensory neuropathy in type 2 diabetes mellitus and to compare it with the duration of disease. Method Two hundred seventy one patients with type 2 diabetes mellitus of both gender age 30 years and above willing to participate were included in this study...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28164387/incidence-of-chronic-kidney-disease-among-people-with-diabetes-a-systematic-review-of-observational-studies
#11
D N Koye, J E Shaw, C M Reid, R C Atkins, A T Reutens, D J Magliano
AIMS: The aim was to systematically review published articles that reported the incidence of chronic kidney disease among people with diabetes. METHODS: A systematic literature search was performed using MEDLINE, Embase and CINAHL databases. The titles and abstracts of all publications identified by the search were reviewed and 10 047 studies were retrieved. RESULTS: A total of 71 studies from 30 different countries with sample sizes ranging from 505 to 211 132 met the inclusion criteria...
February 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28163568/prevalence-of-microalbuminuria-and-its-correlates-among-diabetic-patients-attending-diabetic-clinic-at-national-guard-hospital-in-alhasa
#12
Aneesah A AlFehaid
INTRODUCTION: Diabetes mellitus is one of the most common diseases encountered in clinical practice. Diabetic nephropathy is a common consequence of long-standing diabetes mellitus; microalbuminuria (MA) is considered an early stage of diabetic nephropathy. OBJECTIVES: To determine the prevalence of miciroalbuminuria in diabetic patients and factors associated with MA. MATERIALS AND METHODS: This cross-sectional study was conducted in the diabetic clinic of the primary health center of the National Guard Hospital...
January 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28161386/podocyturia-parallels-proximal-tubule-dysfunction-in-type-2-diabetes-mellitus-patients-independently-of-albuminuria-and-renal-function-decline-a-cross-sectional-study
#13
Ligia Petrica, Mihaela Vlad, Adrian Vlad, Gheorghe Gluhovschi, Florica Gadalean, Victor Dumitrascu, Roxana Popescu, Cristina Gluhovschi, Petru Matusz, Silvia Velciov, Flaviu Bob, Sorin Ursoniu, Daliborca Vlad
AIMS: Detection of podocytes in the urine of patients with type 2 diabetes may indicate severe injury to the podocytes. In the course of type 2 diabetes the proximal tubule is involved in urinary albumin processing. We studied the significance of podocyturia in relation with proximal tubule dysfunction in type 2 diabetes. METHODS: A total of 86 patients with type 2 diabetes (34-normoalbuminuria; 30-microalbuminuria; 22-macroalbuminuria) and 28 healthy subjects were enrolled in the study and assessed concerning urinary podocytes, podocyte-associated molecules, and biomarkers of proximal tubule dysfunction...
January 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28159781/insights-into-diabetic-kidney-disease-using-urinary-proteomics-and-bioinformatics
#14
Julie A D Van, James W Scholey, Ana Konvalinka
A number of proteomic and peptidomic analyses of urine from diabetic subjects have been published in the quest for a biomarker that predicts progression of nephropathy. Less attention has been paid to the relationships between urinary proteins and the underlying biological processes revealed by the analyses. In this review, we focus on the biological processes identified by studying urinary proteins and protein-protein interactions at each stage of diabetic nephropathy to provide an overview of the events underlying progression of kidney disease reflected in the urine...
February 3, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28158221/association-of-prediabetes-associated-single-nucleotide-polymorphisms-with-microalbuminuria
#15
Jong Wook Choi, Shinje Moon, Eun Jung Jang, Chang Hwa Lee, Joon-Sung Park
Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is crucial in the pathogenesis of diabetic microvascular complications represented by microalbuminuria. Nonetheless, there is limited evidence regarding which single nucleotide polymorphisms (SNPs) are associated with prediabetes and whether genetic predisposition to prediabetes is related to microalbuminuria, especially in the general population. Our objective was to answer these questions. We conducted a genomewide association study (GWAS) separately on two population-based cohorts, Ansung and Ansan, in the Korean Genome and Epidemiology Study (KoGES)...
2017: PloS One
https://www.readbyqxmd.com/read/28152985/association-of-estimated-glomerular-filtration-rate-and-urine-albumin-to-creatinine-ratio-with-incidence-of-cardiovascular-diseases-and-mortality-in-chinese-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study
#16
Colman Siu Cheung Fung, Eric Yuk Fai Wan, Anca Ka Chun Chan, Cindy Lo Kuen Lam
BACKGROUND: Estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) are renal markers associated with risks of cardiovascular diseases (CVD) and all-cause mortality in diabetic patients. This study aims to quantify such risks in Chinese diabetic patients based on eGFR and UACR. METHODS: This was a territory-wide retrospective cohort study on primary care diabetic patients with documented eGFR and UACR but without baseline CVD in 2008/2009...
February 2, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28143670/maternal-and-fetal-folate-vitamin-b12-and-homocysteine-concentrations-and-childhood-kidney-outcomes
#17
Kozeta Miliku, Anne Mesu, Oscar H Franco, Albert Hofman, Eric A P Steegers, Vincent W V Jaddoe
BACKGROUND: Folate, vitamin B12, and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring. We examined the associations of folate, vitamin B12, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children. STUDY DESIGN: Population-based prospective cohort study from fetal life onward. SETTINGS & PARTICIPANTS: This study was performed among 4,226 pregnant women and their children...
January 28, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28130832/sarcopenia-is-associated-with-incident-albuminuria-in-patients-with-type-2-diabetes-a-retrospective-observational-study
#18
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Isao Minami, Takanobu Yoshimoto, Yoshihiro Ogawa
Sarcopenia, defined as age-related loss of skeletal muscle mass and function, increases the risk of albuminuria. However, it has still unknown whether sarcopenia could increase the risk for the progression of albuminuria. A total 238 patients with type 2 diabetes (mean age 64 ± 12 years; 39.2% female) were studied in this retrospective observational study. Prevalence of sarcopenia was 17.6%. During the median follow-up period of 2.6 years, albuminuria was measured 5.8 ± 1.8 times and progression of albuminuria was observed in 14...
January 28, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28127216/microalbuminuria-is-a-late-event-in-patients-with-hypertension-do-we-need-a-lower-threshold
#19
Mohamed Abdel Kader Abdel Wahab, Mohamed Mohamed Saad, Khaled Abdel Ghany Baraka
BACKGROUND: Microalbuminuria (MA) is a marker of vascular damage. However, many studies have observed an increased risk at lower levels of albuminuria than are currently used to define MA. AIM: To verify early cardiovascular changes occurring before MA in hypertensive patients. MATERIALS AND METHODS: One hundred and fifty hypertensive patients and 60 normotensive individuals were divided into normotensive individuals with normal left ventricular (LV) geometry (Group I), hypertensive patients with normal LV geometry (Group II), and hypertensive patients with abnormal LV geometry (Group III)...
January 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28124314/microalbuminuria-systemic-inflammation-and-multiorgan-dysfunction-in-decompensated-cirrhosis-evidence-for-a-nonfunctional-mechanism-of-hepatorenal-syndrome
#20
EDITORIAL
Vicente Arroyo
No abstract text is available yet for this article.
January 25, 2017: Hepatology International
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