keyword
MENU ▼
Read by QxMD icon Read
search

Gabaergic

keyword
https://www.readbyqxmd.com/read/28926001/ketamine-differential-neurophysiological-dynamics-in-functional-networks-in-the-rat-brain
#1
A Ahnaou, H Huysmans, R Biermans, N V Manyakov, W H I M Drinkenburg
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic, dissociative and amnestic effects have been well documented to pharmacologically model schizophrenia features in rodents. Sleep-wake architecture, neuronal oscillations and network connectivity are key mechanisms supporting brain plasticity and cognition, which are disrupted in mood disorders such as depression and schizophrenia. In rats, we investigated the dynamic effects of acute and chronic subcutaneous administration of ketamine (2...
September 19, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28925881/coping-with-stress-during-aging-the-importance-of-a-resilient-brain
#2
P Sampedro-Piquero, P Álvarez-Suárez, A Begega
BACKGROUND: Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. METHODS: In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28923348/stimulation-of-accumbal-gabaa-receptors-inhibits-delta2-but-not-delta1-opioid-receptor-mediated-dopamine-efflux-in-the-nucleus-accumbens-of-freely-moving-rats
#3
Yuri Aono, Yuri Kiguchi, Yuriko Watanabe, John L Waddington, Tadashi Saigusa
The nucleus accumbens contains delta-opioid receptors that may reduce inhibitory neurotransmission. Reduction in GABAA receptor-mediated inhibition of accumbal dopamine release due to delta-opioid receptor activation should be suppressed by stimulating accumbal GABAA receptors. As delta-opioid receptors are divided into delta2- and delta1-opioid receptors, we analysed the effects of the GABAA receptor agonist muscimol on delta2- and delta1-opioid receptor-mediated accumbal dopamine efflux in freely moving rats using in vivo microdialysis...
September 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28922859/spatial-embryonic-origin-delineates-gabaergic-hub-neurons-driving-network-dynamics-in-the-developing-entorhinal-cortex
#4
Laura Mòdol, Vitor Hugo Sousa, Arnaud Malvache, Thomas Tressard, Agnes Baude, Rosa Cossart
Coordinated neuronal activity is essential for the development of cortical circuits. GABAergic hub neurons that function in orchestrating early neuronal activity through a widespread net of postsynaptic partners are therefore critical players in the establishment of functional networks. Evidence for hub neurons was previously found in the hippocampus, but their presence in other cortical regions remains unknown. We examined this issue in the entorhinal cortex, an initiation site for coordinated activity in the neocortex and for the activity-dependent maturation of the entire entorhinal-hippocampal network...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922832/fast-spiking-parvalbumin-interneurons-are-frequently-myelinated-in-the-cerebral-cortex-of-mice-and-humans
#5
J Stedehouder, J J Couey, D Brizee, B Hosseini, J A Slotman, C M F Dirven, G Shpak, A B Houtsmuller, S A Kushner
Myelination, the insulating ensheathment of axons by oligodendrocytes, is thought to both optimize signal propagation and provide metabolic support. Despite the well-established physiological importance of myelination to neuronal function, relatively little is known about the myelination of GABAergic interneurons in the cerebral cortex. Here, we report that a large fraction of myelin in mouse cerebral cortex ensheaths GABAergic interneurons, reaching up to 80% in hippocampal subregions. Moreover, we find that a very high proportion of neocortical and hippocampal parvalbumin (PV) interneurons exhibit axonal myelination...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922831/the-transcription-factors-coup-tfi-and-coup-tfii-have-distinct-roles-in-arealisation-and-gabaergic-interneuron-specification-in-the-early-human-fetal-telencephalon
#6
Ayman Alzu'bi, Susan J Lindsay, Lauren F Harkin, Jack McIntyre, Steven N Lisgo, Gavin J Clowry
In human telencephalon at 8-12 postconceptional weeks, ribonucleic acid quantitative sequencing and immunohistochemistry revealed cortical chicken ovalbumin upstream promotor-transcription factor 1 (COUP-TFI) expression in a high ventro-posterior to low anterior gradient except for raised immunoreactivity in the anterior ventral pallium. Unlike in mouse, COUP-TFI and SP8 were extensively co-expressed in dorsal sensory neocortex and dorsal hippocampus whereas COUPTFI/COUPTFII co-expression defined ventral temporal cortex and ventral hippocampus...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28920083/differential-alterations-of-intracellular-ca-2-dynamics-induced-by-cocaine-and-methylphenidate-in-thalamocortical-ventrobasal-neurons
#7
José L Rozas, Belén Goitia, Verónica Bisagno, Francisco J Urbano
The ventrobasal (VB) thalamus relay nucleus processes information from rodents' whiskers, projecting to somatosensory cortex. Cocaine and methylphenidate (MPH) have been described to differentially alter intrinsic properties of, and spontaneous GABAergic input to, VB neurons. Here we studied using bis-fura 2 ratiometric fluorescence the effects of cocaine and MPH on intracellular [Ca(2+)] dynamics at the soma and dendrites of VB neurons. Cocaine increased baseline fluorescence in VB somatic and dendritic compartments...
July 2017: Translational Brain Rhythmicity
https://www.readbyqxmd.com/read/28919309/the-heterogeneity-of-human-cajal-retzius-neurons
#8
REVIEW
Gundela Meyer, Miriam González-Gómez
The definition of a Cajal-Retzius neuron (CRN) is still controversial, in part possibly due to species differences. We review the developmental history of CRN in human neocortex and focus on two main CRN family members, transient (t) and persisting (p) CRN. They share the expression of Reelin andTbr1, complemented by p73, calretinin, CXCR4 and NOS, but differ in their moment of appearance, fate and morphology. The distinctive feature of tCRN is the axon plexus in the lower third of the marginal zone, which innervates the apical dendritic tufts of pyramidal cells and may serve as a migration substrate and waiting compartment for interneurons descending from the subpial granular layer (SGL) into the cortical plate...
September 14, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28918256/transgene-is-specifically-and-functionally-expressed-in-retinal-inhibitory-interneurons-in-the-vgat-chr2-eyfp-mouse
#9
Guo-Zhong Xu, Ling-Jie Cui, Ai-Lin Liu, Wei Zhou, Xue Gong, Yong-Mei Zhong, Xiong-Li Yang, Shi-Jun Weng
Ectopic transgene expression in the retina has been reported in various transgenic mice, indicating the importance of characterizing retinal phenotypes. We examined transgene expression in the VGAT-ChR2-EYFP mouse retina by fluorescent immunohistochemistry and electrophysiology, with special emphasis on EYFP localization in retinal neuronal subtypes identified by specific markers. Strong EYFP signals were detected in both the inner and outer plexiform layers. In addition, the ChR2-EYFP fusion protein was also expressed in somata of the great majority of inhibitory interneurons, including horizontal cells and GABAergic and glycinergic amacrine cells...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28917695/the-impact-of-gabaergic-drugs-on-tms-induced-brain-oscillations-in-human-motor-cortex
#10
Isabella Premoli, Til O Bergmann, Matteo Fecchio, Mario Rosanova, Andrea Biondi, Paolo Belardinelli, Ulf Ziemann
Brain responses to transcranial magnetic stimulation (TMS) as measured with electroencephalography (EEG) have so far been assessed either by TMS-evoked EEG potentials (TEPs), mostly reflecting phase-locked neuronal activity, or time-frequency-representations (TFRs), reflecting oscillatory power arising from a mixture of both evoked (i.e., phase-locked) and induced (i.e., non-phase-locked) responses. Single-pulse TMS of the human primary motor cortex induces a specific pattern of oscillatory changes, characterized by an early (30-200 ms after TMS) synchronization in the α- and β-bands over the stimulated sensorimotor cortex and adjacent lateral frontal cortex, followed by a late (200-400 ms) α- and β-desynchronization over the stimulated and contralateral sensorimotor cortex...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#11
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28916503/altered-serotonergic-and-gabaergic-neurotransmission-in-a-mice-model-of-obsessive-compulsive-disorder
#12
Christine Winter, Dana M Greene, Paraskevi Mavrogiorgou, Helge Schaper, Reinhard Sohr, Abel Bult-Ito, Georg Juckel
There is ample evidence that obsessive-compulsive disorder (OCD) is based on reduced serotonergic function. Replicated bidirectional selection for thermoregulatory nest-building behavior in the laboratory house mouse (Mus musculus) resulted in compulsive-like, non-compulsive-like and randomly bred control mice that represent a non-induced animal model of OCD. The present study aimed at investigating the neurochemical patterns in specific brain regions of compulsive-like (HA) versus non-compulsive-like (LA) and normal (CA) mice...
September 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28916470/receptive-field-properties-of-cat-perigeniculate-neurons-correlate-with-excitatory-and-inhibitory-connectivity-to-lgn-relay-neurons
#13
Hironobu Osaki, Tomoyuki Naito, Shogo Soma, Hiromichi Sato
The cat perigeniculate nucleus (PGN) is a visual sector of the thalamic reticular nucleus that consists of GABAergic neurons. It receives excitatory axon-collateral input from relay neurons of the dorsal lateral geniculate nucleus (LGN) to which it provides inhibitory input. Thus, it is usually argued that the PGN works as feedback inhibition to the LGN. At the single neuron level, however, this circuit can also provide lateral inhibition. Which inhibition dominates in the visual circuit of the thalamus has yet to be well characterized...
September 12, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28916300/distinct-neuronal-populations-in-the-basolateral-and-central-amygdala-are-activated-with-acute-pain-conditioned-fear-and-fear-conditioned-analgesia
#14
Ryan K Butler, Sarah Ehling, Megan Barbar, Jess Thomas, Mary A Hughes, Charles E Smith, Vladimir M Pogorelov, Dipendra K Aryal, William C Wetsel, B Duncan X Lascelles
Fear-conditioned analgesia (FCA) is modulated by brain areas involved in the descending inhibitory pain pathway such as the basolateral (BLA) and central amygdala (CEA). The BLA contains Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and parvalbumin (PV) neurons. CEA neurons are primarily inhibitory (GABAergic) that comprise enkephalin (ENK) interneurons and corticotropin-releasing factor (CRF) - neurons that project to the periaqueductal grey. The purpose of our experiment was to determine the pattern of activation of CaMKII/PV and ENK/CRF neurons following the expression of acute pain, conditioned fear, and FCA...
September 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28912684/distinct-activities-of-tfap2a-and-tfap2b-in-the-specification-of-gabaergic-interneurons-in-the-developing-cerebellum
#15
Norliyana Zainolabidin, Sandhya P Kamath, Ayesha R Thanawalla, Albert I Chen
GABAergic inhibitory neurons in the cerebellum are subdivided into Purkinje cells and distinct subtypes of interneurons from the same pool of progenitors, but the determinants of this diversification process are not well defined. To explore the transcriptional regulation of the development of cerebellar inhibitory neurons, we examined the role of Tfap2A and Tfap2B in the specification of GABAergic neuronal subtypes in mice. We show that Tfap2A and Tfap2B are expressed in inhibitory precursors during embryonic development and that their expression persists into adulthood...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28912551/the-antipsychotic-drugs-olanzapine-and-haloperidol-modify-network-connectivity-and-spontaneous-activity-of-neural-networks-in-vitro
#16
Egor Dzyubenko, Georg Juckel, Andreas Faissner
Impaired neural synchronization is a hallmark of psychotic conditions such as schizophrenia. It has been proposed that schizophrenia-related cognitive deficits are caused by an unbalance of reciprocal inhibitory and stimulatory signaling. This supposedly leads to decreased power of induced gamma oscillations during the performance of cognitive tasks. In light of this hypothesis an efficient antipsychotic treatment should modify the connectivity and synchronization of local neural circuits. To address this issue, we investigated a model of hippocampal neuronal networks in vitro...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912162/regional-cellular-environment-shapes-phenotypic-variations-of-hippocampal-and-neocortical-chandelier-cells
#17
Yugo Ishino, Michael J Yetman, Serena M Sossi, André Steinecke, Yasufumi Hayano, Hiroki Taniguchi
Different cortical regions processing distinct information, such as the hippocampus and the neocortex, share common cellular components and circuit motifs but form unique networks by modifying these cardinal units. Cortical circuits include diverse types of GABAergic interneurons (INs) that shape activity of excitatory principal neurons (PNs). Canonical IN types conserved across distinct cortical regions have been defined by their morphological, electrophysiological, and neurochemical properties. However, it remains largely unknown whether canonical IN types undergo specific modifications in distinct cortical regions and display "regional variants"...
September 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28910740/generation-of-low-gamma-oscillations-in-a-gabaergic-network-model-of-the-striatum
#18
Zhihua Wu, Aike Guo, Xiaodi Fu
Striatal oscillations in the low-gamma frequency range have been consistently recorded in a number of experimental studies. However, whether these rhythms are locally generated in the striatum circuit, which is mainly composed of GABAergic neurons, remains an open question. GABAergic medium spiny projection neurons represent the great majority of striatal neurons, but they fire at very low rates. GABAergic fast-spiking interneurons typically show firing rates that are approximately 10 times higher than those of principal neurons, but they are a very small minority of the total neuronal population...
September 11, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28910619/loss-of-hyperdirect-pathway-cortico-subthalamic-inputs-following-degeneration-of-midbrain-dopamine-neurons
#19
Hong-Yuan Chu, Eileen L McIver, Ryan F Kovaleski, Jeremy F Atherton, Mark D Bevan
The motor symptoms of Parkinson's disease (PD) are linked to abnormally correlated and coherent activity in the cortex and subthalamic nucleus (STN). However, in parkinsonian mice we found that cortico-STN transmission strength had diminished by 50%-75% through loss of axo-dendritic and axo-spinous synapses, was incapable of long-term potentiation, and less effectively patterned STN activity. Optogenetic, chemogenetic, genetic, and pharmacological interrogation suggested that downregulation of cortico-STN transmission in PD mice was triggered by increased striato-pallidal transmission, leading to disinhibition of the STN and increased activation of STN NMDA receptors...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28910446/retinal-astrocytes-and-gabaergic-wide-field-amacrine-cells-express-pdgfr%C3%AE-connection-to-retinal-ganglion-cell-neuroprotection-by-pdgf-aa
#20
Shokichi Takahama, Modupe O Adetunji, Tantai Zhao, Shan Chen, Wei Li, Stanislav I Tomarev
Purpose: Our previous experiments demonstrated that intravitreal injection of platelet-derived growth factor-AA (PDGF-AA) provides retinal ganglion cell (RGC) neuroprotection in a rodent model of glaucoma. Here we used PDGFRα-enhanced green fluorescent protein (EGFP) mice to identify retinal cells that may be essential for RGC protection by PDGF-AA. Methods: PDGFRα-EGFP mice expressing nuclear-targeted EGFP under the control of the PDGFRα promoter were used. Localization of PDGFRα in the neural retina was investigated by confocal imaging of EGFP fluorescence and immunofluorescent labeling with a panel of antibodies recognizing different retinal cell types...
September 1, 2017: Investigative Ophthalmology & Visual Science
keyword
keyword
61439
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"