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https://www.readbyqxmd.com/read/29036931/mass-spectrometric-studies-of-apolipoprotein-proteoforms-and-their-role-in-lipid-metabolism-and-type-2-diabetes
#1
REVIEW
Dobrin Nedelkov
Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes, and ligands for cell-surface receptors. Most of the apoliporoteins exhibit proteoforms, arising from single nucleotide polymorphisms (SNPs) and post-translational modifications such as glycosylation, oxidation, and sequence truncations. Reviewed here are recent studies correlating apolipoproteins proteoforms with the specific clinical measures of lipid metabolism and cardiometabolic risk. Targeted mass spectrometric immunoassays toward apolipoproteins A-I, A-II, and C-III were applied on large cross-sectional and longitudinal clinical cohorts...
October 15, 2017: Proteomes
https://www.readbyqxmd.com/read/29036547/b-type-natriuretic-peptide-and-ventricular-dysfunction-in-the-prediction-of-cardiovascular-events-and-death-in-hypertension
#2
Joe Gallagher, Chris Watson, Shuaiwei Zhou, Fiona Ryan, Mark Ledwidge, Kenneth McDonald
Background: The prevalence and morbidity of hypertension continues to grow globally and improved methods of stratifying risk and identifying organ damage earlier are required. Methods such as echocardiography and population based risk scores are suggested by guidelines as approaches to aid in risk stratification. However, biomarkers such as natriuretic peptides may help provide such an approach. Methods: We analysed data from the STOP-HF cohort including participants with hypertension with and without a history of a cardiovascular event at baseline...
October 4, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29036335/period-effects-in-the-risk-of-subsequent-labour-market-marginalisation-in-young-suicide-attempters
#3
T Niederkrotenthaler, M Helgesson, S Rahman, M Wang, E Mittendorfer-Rutz
Background: Suicide attempt in young age is associated with subsequent labour market marginalisation, but little is known about how marginalisation is affected by changes in suicide attempt rates and social insurance legislation and by age differences. Methods: Prospective cohort study based on register linkage of > 2.4 million Swedish residents per birth cohort, aged 19-40 years in 1999; 2004 and 2009, respectively, and followed up for 4 years. Suicide attempters treated in inpatient care in the three years preceding study entry (n > 7000 per cohort) were compared with the general population of the same age without attempt (1987 to end of follow-up)...
September 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036011/evaluating-the-impact-of-prescription-fill-rates-on-risk-stratification-model-performance
#4
Hsien-Yen Chang, Thomas M Richards, Kenneth M Shermock, Stacy Elder Dalpoas, Hong J Kan, G Caleb Alexander, Jonathan P Weiner, Hadi Kharrazi
BACKGROUND: Risk adjustment models are traditionally derived from administrative claims. Prescription fill rates-extracted by comparing electronic health record prescriptions and pharmacy claims fills-represent a novel measure of medication adherence and may improve the performance of risk adjustment models. OBJECTIVE: We evaluated the impact of prescription fill rates on claims-based risk adjustment models in predicting both concurrent and prospective costs and utilization...
October 13, 2017: Medical Care
https://www.readbyqxmd.com/read/29035943/metabolic-syndrome-and-subclinical-carotid-damage-a-meta-analysis-from-population-based-studies
#5
Cesare Cuspidi, Carla Sala, Fabio Provenzano, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: Metabolic syndrome (MetS) is a phenotype of growing prevalence in the general population. Information on the association between MetS and vascular damage in this setting is only based on data provided by single reports. We performed a meta-analysis of population-based studies aimed to assess the association of MetS with carotid atherosclerosis. DESIGN: Studies were identified by the following search terms: 'metabolic syndrome', 'general population,' 'carotid intima-media thickness' (IMT), 'carotid atherosclerosis,' 'carotid damage,' 'ultrasonography...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29034992/combined-prognostic-value-of-pretreatment-anemia-and-cervical-node-necrosis-in-patients-with-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy-a-large-scale-retrospective-study
#6
Lu-Lu Zhang, Guan-Qun Zhou, Yi-Yang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
This study investigated the combined prognostic value of pretreatment anemia and cervical node necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC). Retrospective review of 1302 patients with newly diagnosed nonmetastatic NPC treated with intensity-modulated radiotherapy (IMRT) ± chemotherapy. Patients were classified into four groups according to anemia and CNN status. Survival was compared using the log-rank test. Independent prognostic factors were identified using the Cox proportional hazards model...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29034771/genome-wide-analysis-of-epstein-barr-virus-identifies-variants-and-genes-associated-with-gastric-carcinoma-and-population-structure
#7
Youyuan Yao, Miao Xu, Liming Liang, Haojiong Zhang, Ruihua Xu, Qisheng Feng, Lin Feng, Bing Luo, Yi-Xin Zeng
Epstein-Barr virus is a ubiquitous virus and is associated with several human malignances, including the significant subset of gastric carcinoma, Epstein-Barr virus-associated gastric carcinoma. Some Epstein-Barr virus-associated diseases are uniquely prevalent in populations with different geographic origins. However, the features of the disease and geographically associated Epstein-Barr virus genetic variation as well as the roles that the variation plays in carcinogenesis and evolution remain unclear. Therefore, in this study, we sequenced 95 geographically distinct Epstein-Barr virus isolates from Epstein-Barr virus-associated gastric carcinoma biopsies and saliva of healthy donors to detect variants and genes associated with gastric carcinoma and population structure from a genome-wide spectrum...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29034236/prognostic-value-of-the-new-prostate-cancer-international-society-of-urological-pathology-grade-groups
#8
Anne Offermann, Silke Hohensteiner, Christiane Kuempers, Julika Ribbat-Idel, Felix Schneider, Finn Becker, Marie Christine Hupe, Stefan Duensing, Axel S Merseburger, Jutta Kirfel, Markus Reischl, Verena Lubczyk, Rainer Kuefer, Sven Perner
Gleason grading is the best independent predictor for prostate cancer (PCa) progression. Recently, a new PCa grading system has been introduced by the International Society of Urological Pathology (ISUP) and is recommended by the World Health Organization (WHO). Following studies observed more accurate and simplified grade stratification of the new system. Aim of this study was to compare the prognostic value of the new grade groups compared to the former Gleason Grading and to determine whether re-definition of Gleason Pattern 4 might reduce upgrading from prostate biopsy to radical prostatectomy (RP) specimen...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033605/onabotulinum-toxin-a-in-the-treatment-of-chronic-migraine-patient-selection-and-special-considerations
#9
REVIEW
Piero Barbanti, Patrizia Ferroni
Discovered by serendipity, onabotulinum toxin A (BoNT-A) is the only US Food and Drug Administration-approved treatment for the prevention of chronic migraine (CM), one of the most disabling and burdensome human conditions. Its efficacy, safety and tolerability, proved by the largest and longest migraine therapeutic trial (the Phase III Research Evaluating Migraine Prophylaxis Therapy program [PREEMPT]), have been replicated by various real-life studies also in the presence of medication overuse. The benefit of BoNT-A prophylaxis is likely due to its ability to counteract peripheral and central nociceptive sensitization through reversible chemical denervation of pericranial sensitive afferents...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033514/the-association-between-cha2ds2-vasc-score-and-mortality-in-patients-with-heart-failure-with-reduced-ejection-fraction
#10
Orkun Temizer, Burak Açar, Çağrı Yayla, Sefa Ünal, Ahmet Göktuğ Ertem, Esra Gücük İpek, Uğur Canpolat, Bihter Şentürk, Hatice Selçuk, Timur Selçuk
BACKGROUND: Heart failure (HF) is associated with significant mortality and morbidity. Therefore, identifying high-risk patients may optimize treatment for HF patients and reduce adverse events. The aim of this study was to assess the role of the CHA2DS2-VASc score to predict mortality in patients with reduced left ventricular ejection fraction (LVEF). METHODS: A total of 106 patients with reduced LVEF were enrolled in this study. All patients completed a one-year follow-up, and a CHA2DS2-VASc score was calculated for each patient...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29032885/the-subtle-connection-between-development-of-cardiac-implantable-electrical-device-infection-and-survival-after-complete-system-removal-an-observational-prospective-multicenter-study
#11
Igor Diemberger, Federico Migliore, Mauro Biffi, Alberto Cipriani, Emanuele Bertaglia, Stefano Lorenzetti, Giulia Massaro, Gaia Tanzarella, Giuseppe Boriani
BACKGROUND: Despite the improvements in transvenous lead extraction (TLE), patients with cardiac implantable device related infection (CIEDI) have a poor prognosis at long term. We explored the possible role of factors associated with development of CIEDI as predictors of post-TLE survival. METHODS: We performed a multi-center prospective observational study in a population of consecutive patients referred for TLE for CIEDI. We adopted a previously developed 10-point scale for CIEDI risk stratification and assessed its performance in predicting post-TLE survival...
October 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29032852/limited-influence-of-primary-treated-sewage-waters-on-bacterial-abundance-production-and-community-composition-in-coastal-seawaters
#12
Paolo Paliaga, Marino Korlević, Ingrid Ivančić, Mirjana Najdek
The response of bacteria in terms of abundance, production and community structure to changes induced by the discharge of primary treated sewage waters was investigated combining microbiological, chemical and molecular tools. The primary treatment did not affect substantially the bacterial community structure in wastewaters and did not reduce the concentrations of fecal indicators. The spatial distribution of the sewage plume was governed by vertical stratification and currents. Bacterial abundance and production in the sea receiving waste waters depended predominantly on environmental conditions...
September 23, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29032731/cytogenetic-risk-stratification-may-predict-allogeneic-hematopoietic-stem-cell-transplantation-outcomes-for-chronic-myelomonocytic-leukemia
#13
Kenji Motohashi, Shin Fujisawa, Noriko Doki, Takeshi Kobayashi, Takehiko Mori, Kensuke Usuki, Masatsugu Tanaka, Shinichiro Fujiwara, Shinichi Kako, Yasuyuki Aoyama, Masahiro Onoda, Shingo Yano, Moritaka Gotoh, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment for chronic myelomonocytic leukemia (CMML); however, factors predicting allo-HSCT outcomes for CMML have not been well defined. This study assessed whether the existing five scoring systems for CMML prognosis could be applied for predicting allo-HSCT outcomes. We retrospectively evaluated 38 patients who underwent allo-HSCT for CMML from 2000 to 2014. At 3 years, overall survival (OS) and disease-free survival were 34...
October 16, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29032362/simple-six-item-clinical-score-improves-risk-prediction-capability-of-stress-echocardiography
#14
Lauro Cortigiani, Clara Carpeggiani, Rosa Sicari, Claudio Michelassi, Francesco Bovenzi, Eugenio Picano
OBJECTIVES: To assess the value of a simple score integrating non-ischaemia-related variables in expanding the wall motion abnormalities risk power during stress echocardiography (SE). METHODS: Study includes 14 279 patients who underwent SE for evaluation of coronary artery disease. All-cause death was the end point. Patients were randomly divided into the modelling and validation group of equal size. In the modelling group, multivariate analysis was conducted using clinical, rest and SE data, and a score was obtained from the number of non-ischaemia-related independent prognostic predictors...
October 14, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29032269/second-hematopoietic-sct-for-thalassemia-major-improved-clinical-outcomes-with-a-treosulfan-based-conditioning-regimen
#15
Anu Korula, Nisham P N, Anup Devasia, Kavitha M Lakshmi, Aby Abraham, Eunice Sindhuvi, Biju George, Alok Srivastava, Vikram Mathews
Graft rejection (GR) following an allo-SCT occurs in 10-20% of patients with β thalassemia major (TM). There is limited data on the clinical profile and long term outcome of patients who have had a graft rejection. We undertook a retrospective analysis of patients who had a graft failure post allogeneic SCT for TM at our center. From October, 1991 to June 2016, 55/506 (11%) patients transplanted for TM had a graft failure. An additional 7 patients with graft failure following an allo-SCT done at other centers were referred to us for a second transplant...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29032131/association-between-type-2-diabetes-and-all-cause-hospitalization-and-mortality-in-the-uk-general-heart-failure-population-stratification-by-diabetic-glycemic-control-and-medication%C3%A2-intensification
#16
Claire A Lawson, Peter W Jones, Lucy Teece, Sandra B Dunbar, Petar M Seferovic, Kamlesh Khunti, Mamas Mamas, Umesh T Kadam
OBJECTIVES: This study sought to investigate in the general heart failure (HF) population, whether the associations between type 2 diabetes (T2D) and risk of hospitalization and death, are modified by changing glycemic or drug treatment intensity. BACKGROUND: In the general HF population, T2D confers a higher risk of poor outcomes, but whether this risk is modified by the diabetes status is unknown. METHODS: A nested case-control study in an incident HF database cohort (2002 to 2014) comparing patients with T2D with those without, for risk of all-cause first hospitalization and death...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29031911/gene-polymorphisms-of-disc1-is-associated-with-schizophrenia-evidence-from-a-meta-analysis
#17
REVIEW
Hong-Yu Wang, Yong Liu, Jun-Wei Yan, Xing-Long Hu, Dao-Min Zhu, Xiao-Tong Xu, Xiao-Si Li
BACKGROUND: Previous studies suggest an association between Disrupted in schizophrenia 1 (DISC1) polymorphisms and schizophrenia (SCZ). However, the available data are often inconsistent, regarding the difference in sample size, ethnicity, genotyping method, etc. Thus, we carried out a meta-analysis to determine whether DISC1 polymorphisms contributed susceptibility to SCZ. METHODS: A methodical literature review was operated using the English and Chinese core electronic databases...
October 12, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29030415/comorbidity-and-outcomes-in-traumatic-brain-injury-protocol-for-a-systematic-review-on-functional-status-and-risk-of-death
#18
Tatyana Mollayeva, Chen Xiong, Sara Hanafy, Vincy Chan, Zheng Jing Hu, Mitchell Sutton, Michael Escobar, Angela Colantonio
INTRODUCTION: Reports on the association between comorbidity and functional status and risk of death in patients with traumatic brain injury (TBI) have been inconsistent; it is currently unknown which additional clinical entities (comorbidities) have an adverse influence on the evolution of outcomes across the lifespan of men and women with TBI. The current protocol outlines a strategy for a systematic review of the current evidence examining the impact of comorbidity on functional status and early-term and late-term mortality, taking into account known risk factors of these adverse outcomes (ie, demographic (age and sex) and injury-related characteristics)...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29030381/risk-stratification-for-sudden-cardiac-death-in-individuals-without-structural-disease-implications-from-studies-of-rare-genetic-arrhythmic-disorders
#19
EDITORIAL
Ilan Goldenberg, Arthur J Moss
No abstract text is available yet for this article.
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29030355/a-prognostic-bio-model-based-on-sqstm1-and-n-stage-identifies-nasopharyngeal-carcinoma-patients-at-high-risk-of-metastasis-for-additional-induction-chemotherapy
#20
Qi Yang, Meng-Xia Zhang, Xiong Zou, You-Ping Liu, Rui You, Tao Yu, Rou Jiang, Yi-Nuan Zhang, Jing-Yu Cao, Ming-Huang Hong, Qing Liu, Ling Guo, Tiebang Kang, Xiaofeng Zhu, Ming-Yuan Chen
PURPOSE: Metastasis is one of the most important causes of treatment failure in nasopharyngeal carcinoma (NPC). In T4 or N2-3 patients at high risk of metastasis, concurrent chemoradiotherapy (CCRT) is inadequate and additional induction chemotherapy (IC) is controversial. There is a critical need to develop a better patient stratification to efficiently identify patients at high risk of metastasis for additional IC. Recently, Sequestosome 1 (SQSTM1)/p62, an autophagy adaptor protein, was identified as one of the metastasis-related proteins in NPC...
October 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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