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Risk Stratification

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https://www.readbyqxmd.com/read/29442058/multiparametric-evaluation-of-risk-factors-associated-to-seroma-formation-in-abdominal-wall-surgery
#1
L Licari, G Salamone, Z Parinisi, S Campanella, C Sabatino, G Ciolino, P De Marco, N Falco, S Boventre, G Gulotta
INTRODUCTION: Incisional hernia is one of the main topics in the general surgery since there is not a unanimous consensus concerning to the best surgical methodology to adopt. It seems that prosthetic surgery is the best technique, even if responsible for the development of periprosthetic seroma. The aim of this study is to assess whether the preoperative abnormalities of the bio-humoral parameters may be considered as risk factors for seroma. PATIENTS AND METHODS: From July 2016 to July 2017 at the "Policlinico Paolo Giaccone", Palermo, Department of Emergency Surgery, 56 patients included in this study, underwent laparotomic mesh repair...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29441737/cesium-137-contaminated-roads-and-health-problems-in-residents-an-epidemiological-investigation-in-seoul-2011
#2
Mina Ha, Young Su Ju, Won Jin Lee, Seung Sik Hwang, Sang Chul Yoo, Kyung Hwa Choi, Eunae Burm, Jieon Lee, Yun Keun Lee, Sanghyuk Im
BACKGROUND: In 2011, two roads in a residential area in Seoul were found to be contaminated with the radionuclide cesium-137 (137Cs). In response to public concerns, an epidemiological study was conducted. METHODS: The standardized cancer incidence ratios in the affected and neighboring regions were calculated based on the central cancer registry. Households in the region were sampled using the random stratified sampling technique, and questionnaires were administered to family members, via home visit and via students in elementary to high schools...
February 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29440932/comparison-of-prognostic-prediction-between-nomogram-based-on-lymph-node-ratio-and-ajcc-8th-staging-system-for-patients-with-resected-pancreatic-head-carcinoma-a-seer-analysis
#3
Ning Pu, Jianang Li, Yaolin Xu, Wanling Lee, Yuan Fang, Xu Han, Guochao Zhao, Lei Zhang, Abulimiti Nuerxiati, Hanlin Yin, Wenchuan Wu, Wenhui Lou
Background: The prognosis of pancreatic carcinoma (PC) remains poor and the American Joint Committee on Cancer (AJCC) 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, the aim of this study is to refine a valuable prognostic model and novel staging system for PC with curative resection. Methods: The data of 3,458 patients used in this study were retrieved from the Surveillance, Epidemiology, and End Results database registry of National Cancer Institute...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29440330/assessment-of-the-fullpiers-risk-prediction-model-in-women-with-early-onset-preeclampsia
#4
U Vivian Ukah, Beth Payne, Jennifer A Hutcheon, J Mark Ansermino, Wessel Ganzevoort, Shakila Thangaratinam, Laura A Magee, Peter von Dadelszen
Early-onset preeclampsia is associated with severe maternal and perinatal complications. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) showed both internal and external validities for predicting adverse maternal outcomes within 48 hours for women admitted with preeclampsia at any gestational age. This ability to recognize women at the highest risk of complications earlier could aid in preventing these adverse outcomes through improved management. Because the majority (≈70%) of the women in the model development had late-onset preeclampsia, we assessed the performance of the fullPIERS model in women with early-onset preeclampsia to determine whether it will be useful in this subgroup of women with preeclampsia...
February 12, 2018: Hypertension
https://www.readbyqxmd.com/read/29440233/comprehensive-characterisation-of-compartment-specific-long-non-coding-rnas-associated-with-pancreatic-ductal-adenocarcinoma
#5
Luis Arnes, Zhaoqi Liu, Jiguang Wang, Hans Carlo Maurer, Irina Sagalovskiy, Marta Sanchez-Martin, Nikhil Bommakanti, Diana C Garofalo, Dina A Balderes, Lori Sussel, Kenneth P Olive, Raul Rabadan
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. DESIGN: We developed a computational framework to reconstruct the non-coding transcriptome from cross-sectional RNA-Seq, integrating somatic copy number alterations (SCNA), common germline variants associated to PDA risk and clinical outcome...
February 10, 2018: Gut
https://www.readbyqxmd.com/read/29440123/portrait-patient-centered-outcomes-related-to-treatment-practices-in-peripheral-arterial-disease-investigating-trajectories-overview-of-design-and-rationale-of-an-international-prospective-peripheral-arterial-disease-study
#6
REVIEW
Kim G Smolderen, Kensey Gosch, Manesh Patel, W Schuyler Jones, Alan T Hirsch, John Beltrame, Rob Fitridge, Mehdi H Shishehbor, Johan Denollet, Patrick Vriens, Jan Heyligers, Nancy Stone MEd, Herbert Aronow, J Dawn Abbott, Clementine Labrosciano, Rudolf Tutein-Nolthenius, John A Spertus
BACKGROUND: Health status outcomes, including symptoms, functional status, and quality of life, are critically important outcomes from patients' perspectives. The PORTRAIT study (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) was designed to prospectively define health status outcomes and examine associations between patients' characteristics and care to these outcomes among those presenting with new-onset or worsened claudication...
February 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29439887/a-challenge-for-mutation-specific-risk-stratification-in-long-qt-syndrome-type-1
#7
Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno
BACKGROUND: The relationship between mutation locations in KCNQ1 which is a major gene in long QT syndrome (LQTS) and phenotype has been analyzed and used for risk stratification. Mutations in the transmembrane region (TM) or cytoplasmic-loop (C-loop) are associated with more frequent cardiac events than those in other regions. However, accumulation of LQTS type 1 (LQT1) patients poses the question of whether the location specific risk stratification is really effective. METHODS: The study cohort consisted of 67 KCNQ1 mutation carriers and 13 family members who were suspected as having LQTS due to sudden cardiac death or syncope from 36 unrelated families...
February 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29439612/a-nomogram-based-on-the-characteristics-of-metastatic-lymph-nodes-to-predict-papillary-thyroid-carcinoma-recurrence
#8
Jianyong Lei, Jinjing Zhong, Zhihui Li, Tao Wei, Rixiang Gong, Jinqiang Zhu
BACKGROUND AND AIMS: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk. PATIENTS AND METHODS: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29439530/analysis-of-the-high-frequency-content-in-human-qrs-complexes-by-the-continuous-wavelet-transform-an-automatized-analysis-for-the-prediction-of-sudden-cardiac-death
#9
Daniel García Iglesias, Nieves Roqueñi Gutiérrez, Francisco Javier De Cos, David Calvo
BACKGROUND: Fragmentation and delayed potentials in the QRS signal of patients have been postulated as risk markers for Sudden Cardiac Death (SCD). The analysis of the high-frequency spectral content may be useful for quantification. METHODS: Forty-two consecutive patients with prior history of SCD or malignant arrhythmias (patients) where compared with 120 healthy individuals (controls). The QRS complexes were extracted with a modified Pan-Tompkins algorithm and processed with the Continuous Wavelet Transform to analyze the high-frequency content (85-130 Hz)...
February 12, 2018: Sensors
https://www.readbyqxmd.com/read/29438762/the-impact-of-underlying-disease-state-on-outcomes-in-patients-with-pyoderma-gangrenosum-a-national-survey
#10
Benjamin H Kaffenberger, Alice Hinton, Somashekar Krishna
BACKGROUND: It is unclear if the underlying disease affects the outcomes in pyoderma gangrenosum. OBJECTIVES: To determine the impact of comorbid disease associations and concomitant procedural treatments on patient outcomes in PG patient-hospitalizations. METHODS: A cross-sectional analysis of the Nationwide Inpatient Sample (NIS) for PG patient-hospitalizations from years 2002-2011, analyzing in-hospital mortality rate and health care resource utilization...
February 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29438654/the-significance-of-repeat-cultures-in-the-treatment-of-severe-fungal-keratitis
#11
Kathryn J Ray, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Tiruvengada Krishnan, Sushila Patel, Manoranjan Das, Ranjeet Shah, Kavita Dhakhwa, Stephen D McLeod, Michael E Zegans, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: To identify fungal keratitis patients who are at risk of a poor outcome and may benefit from closer follow-up or more aggressive treatment. DESIGN: Secondary analysis of randomized clinical trial data. SUBJECTS: Patients presenting with a smear-positive filamentous fungal ulcer, visual acuity of 20/400 or worse, and who subsequently had a 6-day fungal culture performed at the Aravind Eye Care system (India), Lumbini Eye Hospital (Nepal), or Bharatpur Eye Hospital (Nepal)...
February 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29438470/use-of-clinical-risk-stratification-in-non-st-elevation-acute-coronary-syndromes-an-analysis-from-the-concordance-registry
#12
Rong Bing, Shaun G Goodman, Andrew T Yan, Keith Fox, Chris P Gale, Karice Hyun, Mario D'Souza, Pratap Shetty, John Atherton, Chris Hammett, Derek Chew, David Brieger
No abstract text is available yet for this article.
February 9, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29437906/cardiac-troponin-for-predicting-all-cause-mortality-in-patients-with-acute-ischemic-stroke-a-meta-analysis
#13
Yu Fan, Menglin Jiang, Dandan Gong, Changfeng Man, Yuehua Chen
Cardiac troponins are specific biomarkers of cardiac injury. However, the prognostic usefulness of cardiac troponin in patients with acute ischemic stroke is still controversial. The objective of this meta-analysis was to investigate the association of cardiac troponin elevation with all-cause mortality in patients with acute ischemic stroke. PubMed and Embase databases were searched for relevant studies up to April 31, 2017. All observational studies reporting an association of baseline cardiac troponin-T (cTnT) or troponin-I (cTnI) elevation with all-cause mortality risk in patients with acute ischemic stroke were included...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29437742/implantable-cardioverter-defibrillators-in-the-context-of-hypertrophic-cardiomyopathy-a-lesson-in-patient-autonomy
#14
Jonathan James Hyett Bray, Chiara Bucciarelli-Ducci, Graham Stuart
Hypertrophiccardiomyopathy (HCM) is common, whereas the decision not to have an implantable cardioverterdefibrillator (ICD) when probably falling into a 'high-risk' category is not. A solicitor aged 45 years attended the inherited cardiac conditions clinic for review of her HCM and discussion about ICD implantation for primary prevention of sudden cardiac death (SCD). Despite a predicted 7% risk of SCD within the next 5 years, according to the European Society of Cardiology endorsed HCM Risk-SCD risk stratification tool, the patient opted against implantation of an ICD and comprehensively justifies her decision...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437271/novel-radiomic-signature-as-a-prognostic-biomarker-for-locally-advanced-rectal-cancer
#15
Yankai Meng, Yuchen Zhang, Di Dong, Chunming Li, Xiao Liang, Chongda Zhang, Lijuan Wan, Xinming Zhao, Kai Xu, Chunwu Zhou, Jie Tian, Hongmei Zhang
BACKGROUND: Locally advanced rectal cancer (LARC) patient stratification by clinicoradiologic factors may yield variable results. Therefore, more efficient prognostic biomarkers are needed for improved risk stratification of LARC patients, personalized treatment, and prognostication. PURPOSE/HYPOTHESIS: To compare the ability of a radiomic signature to predict disease-free survival (DFS) with that of a clinicoradiologic risk model in individual patients with LARC...
February 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29437039/microrna-1246-is-an-exosomal-biomarker-for-aggressive-prostate-cancer
#16
Divya Bhagirath, Thao Ly Yang, Nathan Bucay, Kirandeep Sekhon, Shahana Majid, Varahram Shahryari, Rajvir Dahiya, Yuichiro Tanaka, Sharanjot Saini
Due to high heterogeneity, molecular characterization of prostate cancer (PCa) based on biopsy sampling is often challenging. Hence, a minimally invasive method to determine the molecular imprints of a patient's tumor for risk stratification would be advantageous. In this study, we employ a novel, digital amplification-free quantification method using the nCounter technology (Nanostring Technologies) to profile exosomal serum miRNAs (ex-miRNA) from aggressive PCa cases, benign prostatic hyperplasia (BPH), and disease-free controls...
February 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/29436442/ambulatory-emergency-care-improvement-by-design
#17
Mahir Mustafa Abdel Aziz Hamad, Vincent M Connolly
Ambulatory emergency care (AEC) has been developed by clinicians as a means of providing emergency care without the traditional bed base of a hospital. Given that AEC is provided in a clinic-style setting, it can continue to operate during periods of high bed occupancy, alleviating bed pressures and continuing to provide timely care for selected patients. Although different models of AEC have developed according to local context, there are common principles that apply to AEC services, including early access to senior decision-makers, opening hours matching demand, access to diagnostics, close collaboration with other clinical services, a mixed workforce and patient selection processes...
February 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29436276/utility-of-the-modified-surgical-apgar-score-in-a-head-and-neck-cancer-population
#18
Kristine E Day, Andrew C Prince, Chee Paul Lin, Benjamin J Greene, William R Carroll
Objective The Surgical Apgar Score (SAS) is a validated postoperative complication prediction model. The purpose of this study was to investigate the utility of the SAS in a diverse head and neck cancer population and to compare it with a recently developed modified SAS (mSAS) that accounts for intraoperative transfusion. Study Design Case series with chart review. Setting Academic tertiary care medical center. Subjects and Methods This study comprised 713 patients undergoing surgery for head and neck cancer from April 2012 to March 2015...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29435002/tert-promoter-mutations-and-their-correlation-with-braf-and-ras-mutations-in-a-consecutive-cohort-of-145-thyroid-cancer-cases
#19
Andrea Cacciato Insilla, Agnese Proietti, Nicla Borrelli, Elisabetta Macerola, Cristina Niccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for this reason, recent advances in molecular genetics of thyroid cancer can be applied to provide novel biomarkers useful in understanding tumor behavior. B-Raf proto-oncogene, serine/threonine kinase (BRAF) and rat sarcoma (RAS) mutations have been widely studied and appear to have an important role in thyroid tumorigenesis...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434357/risk-stratification-based-on-components-of-the-complete-blood-count-in-patients-with-acute-coronary-syndrome-a-classification-and-regression-tree-analysis
#20
Xiaowei Niu, Guoyong Liu, Lichao Huo, Jingjing Zhang, Ming Bai, Yu Peng, Zheng Zhang
To develop a risk stratification model based on complete blood count (CBC) components in patients with acute coronary syndrome (ACS) using a classification and regression tree (CART) method. CBC variables and the Global Registry of Acute Coronary Events (GRACE) scores were determined in 2,693 patients with ACS. The CART analysis was performed to classify patients into different homogeneous risk groups and to determine predictors for major adverse cardiovascular events (MACEs) at 1-year follow-up. The CART algorithm identified the white blood cell count, hemoglobin, and mean platelet volume levels as the best combination to predict MACE risk...
February 12, 2018: Scientific Reports
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