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Glaucoma structure function

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https://www.readbyqxmd.com/read/28545121/measurement-of-macular-structure-function-relationships-using-spectral-domain-optical-coherence-tomography-sd-oct-and-pattern-electroretinograms-perg
#1
Keunheung Park, Jinmi Kim, Jiwoong Lee
BACKGROUND: Retinal ganglion cell (RGC) death is a common cause of loss of vision during glaucoma. Pattern electroretinogram (PERG) is an objective measure of the central retinal function that correlates with macular GCL thickness. The aim of this study is to determine possible relationships between the N95 amplitude of pattern electroretinogram (PERGamp) and macular ganglion cell/inner plexiform layer thickness (GCIPLT). METHODS AND FINDINGS: This was a retrospective and comparative study including 74 glaucoma patients (44 early stage and 30 advanced stage cases) and 66 normal control subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28532392/diagnostic-performance-of-isolated-check-visual-evoked-potential-versus-retinal-ganglion-cell-inner-plexiform-layer-analysis-in-early-primary-open-angle-glaucoma
#2
XiangWu Chen, YingXi Zhao
BACKGROUND: The purpose of this study was to compare the diagnostic performance of isolated-check visual evoked potential (icVEP) with that of retinal ganglion cell-inner plexiform layer (GCILP) analysis using optical coherence tomography (OCT). METHODS: A total of 45 patients were enrolled: 25 patients with open-angle glaucoma and 20 healthy patients. All patients underwent a complete ophthalmological examination. Moreover, the OCT examination was used to analyze the structures of the GCIPL...
May 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28528864/effects-of-collagen-microstructure-and-material-properties-on-the-deformation-of-the-neural-tissues-of-the-lamina-cribrosa
#3
A P Voorhees, N-J Jan, I A Sigal
It is widely considered that intraocular pressure (IOP)-induced deformation within the neural tissue pores of the lamina cribrosa (LC) contributes to neurodegeneration and glaucoma. Our goal was to study how the LC microstructure and mechanical properties determine the mechanical insult to the neural tissues within the pores of the LC. Polarized light microscopy was used to measure the collagen density and orientation in histology sections of three sheep optic nerve heads (ONH) at both mesoscale (4.4 μm) and microscale (0...
May 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28528295/a-machine-learning-graph-based-approach-for-3d-segmentation-of-bruch-s-membrane-opening-from-glaucomatous-sd-oct-volumes
#4
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Milan Sonka, Mona K Garvin
Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points in individual B-scans, in this work, we propose a machine-learning graph-based approach for true 3D segmentation of BMO from glaucomatous SD-OCT volumes...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28526237/small-molecule-inhibition-of-wnt-signaling-abrogates-dexamethasone-induced-phenotype-of-primary-human-trabecular-meshwork-cells
#5
Sarah D Ahadome, Chi Zhang, Elizabeth Tannous, James Shen, Jie J Zheng
Trabecular meshwork (TM) cells are the governing regulators of the TM structure. When the functionality of these cells is impaired, the structure of the TM is perturbed, which often results in increased ocular hypertension. High intraocular pressure is the most significant risk factor for steroid-induced glaucoma. Dexamethasone (Dex) induced phenotype of TM cells is widely utilized as a model system to gain insight into mechanisms underlying damaged TM in glaucoma. In this study, to assess the possible role of the abnormal Wnt signaling in steroid-induced glaucoma, we analyzed the effects of small-molecule Wnt signaling modulators on Dex-induced expression extracellular matrix proteins of primary human TM cells...
May 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28475699/biomarkers-and-surrogate-endpoints-lessons-learned-from-glaucoma
#6
Felipe A Medeiros
With the recent progress in imaging technologies for assessment of structural damage in glaucoma, a debate has emerged on whether these measurements can be used as valid surrogate endpoints in clinical trials evaluating new therapies for the disease. A discussion of surrogates should be grounded on knowledge acquired from their use in other areas of medicine as well as regulatory requirements. This article reviews the conditions for valid surrogacy in the context of glaucoma clinical trials and critically evaluates the role of biomarkers such as IOP and imaging measurements as potential surrogates for clinically relevant outcomes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28439944/using-perimetric-data-to-estimate-ganglion-cell-loss-for-detecting-progression-of-glaucoma-a-comparison-of-models
#7
Derek A Price, William H Swanson, Douglas G Horner
PURPOSE: Models relating perimetric sensitivities to ganglion cell numbers have been proposed for combining structural and functional measures from patients with glaucoma. Here we compared seven models for ability to differentiate progressing and stable patients, testing the hypothesis that the model incorporating local spatial scale would have the best performance. METHODS: The models were compared for the United Kingdom Glaucoma Treatment Study (UKGTS) data for the right eyes of 489 patients recently diagnosed with glaucoma...
April 25, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28424571/metabolic-vulnerability-in-the-neurodegenerative-disease-glaucoma
#8
REVIEW
Denise M Inman, Mohammad Harun-Or-Rashid
Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even seemingly subtle modifications of metabolism can result in functional deficits and degeneration. Axons require a great deal of energy, up to 70% of all energy used by a neuron, just to maintain the resting membrane potential. Axonal energy, in the form of ATP, is generated primarily through oxidative phosphorylation in the mitochondria...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28396439/structural-basis-of-tie2-activation-and-tie2-tie1-heterodimerization
#9
Veli-Matti Leppänen, Pipsa Saharinen, Kari Alitalo
The endothelial cell (EC)-specific receptor tyrosine kinases Tie1 and Tie2 are necessary for the remodeling and maturation of blood and lymphatic vessels. Angiopoietin-1 (Ang1) growth factor is a Tie2 agonist, whereas Ang2 functions as a context-dependent agonist/antagonist. The orphan receptor Tie1 modulates Tie2 activation, which is induced by association of angiopoietins with Tie2 in cis and across EC-EC junctions in trans Except for the binding of the C-terminal angiopoietin domains to the Tie2 ligand-binding domain, the mechanisms for Tie2 activation are poorly understood...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28394809/structure-function-relationship-between-the-bruch-membrane-opening-based-minimum-rim-width-and-visual-field-defects-in-advanced-glaucoma
#10
Serhat Imamoglu, Nimet Burcu Celik, Mehmet S Sevim, Gokhan Pekel, Nimet Yesim Ercalik, Esra Turkseven Kumral, Handan Bardak
PURPOSE: To investigate the relationship between the Bruch membrane opening-minimum rim width (BMO-MRW) (global and temporal) parameters with spectral-domain optical coherence tomography (SD-OCT) and visual field (VF) sensitivity on the 10-2 test in patients with advanced glaucoma. MATERIALS AND METHODS: This cross-sectional, observational study included a total of 33 eyes of 29 patients. To evaluate VF sensitivity, automated white-on-white perimetry was performed using a Humphrey field analyzer...
April 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28386709/in-silico-analysis-of-five-missense-mutations-in-cyp1b1-gene-in-pakistani-families-affected-with-primary-congenital-glaucoma
#11
Sabika Firasat, Haiba Kaul, Usman Ali Ashfaq, Sobia Idrees
PURPOSE: The purpose of this study was to characterize the five missense mutations in CYP1B1 gene identified in Pakistani families affected with primary congenital glaucoma (PCG) using various bioinformatics and protein modeling tools. METHODS: We previously reported four novel missense mutations in CYP1B1 gene segregating in consanguineous Pakistani families. These mutations were identified by direct sequencing of all coding exons, the exon-intron boundaries and the 5' untranslated region of CYP1B1 using genomic DNA from affected and unaffected family members...
April 6, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28349508/targeting-schlemm-s-canal-in-the-medical-therapy-of-glaucoma-current-and-future-considerations
#12
REVIEW
Vanessa Andrés-Guerrero, Julián García-Feijoo, Anastasios Georgios Konstas
Schlemm's canal (SC) is a unique, complex vascular structure responsible for maintaining fluid homeostasis within the anterior segment of the eye by draining the excess of aqueous humour. In glaucoma, a heterogeneous group of eye disorders afflicting approximately 60 million individuals worldwide, the normal outflow of aqueous humour into SC is progressively hindered, leading to a gradual increase in outflow resistance, which gradually results in elevated intraocular pressure (IOP). By and large available antiglaucoma therapies do not target the site of the pathology (SC), but rather aim to decrease IOP by other mechanisms, either reducing aqueous production or by diverting aqueous flow through the unconventional outflow system...
May 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28342719/association-of-structural-and-functional-measures-with-contrast-sensitivity-in-glaucoma
#13
Nima Fatehi, Sara Nowroozizadeh, Sharon Henry, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
PURPOSE: To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN: Cross-sectional prospective study. METHODS: 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses...
March 22, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337061/an-introduction-to-darc-technology
#14
REVIEW
Syed Shoeb Ahmad
Glaucoma is a multi-factorial neurodegenerative disorder. The common denominator in all types of glaucomas is retinal ganglion cell death through apoptosis. However, this cellular demise in glaucoma is detected late by structural or functional analyses. There can be a 10-year delay prior to the appearance of visual field defects and pre-perimetric glaucoma is an issue still being addressed. However, a new cutting-edge technology called detection of apoptosing retinal cells (DARC) is being developed. This technique is capable of non-invasive, real-time visualization of apoptotic changes at the cellular level...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28333896/relationship-of-optic-nerve-structure-and-function-to-peripapillary-vessel-density-measurements-of-optical-coherence-tomography-angiography-in-glaucoma
#15
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Sharanya Raveendran, Narendra K Puttaiah, Jayasree P Venugopal, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To evaluate the sectoral and global structure-structure (vessel density-retinal nerve fiber layer thickness) and structure-function (vessel density-visual sensitivity loss) relationships of peripapillary vessel density measurements on optical coherence tomography angiography in primary open-angle glaucoma and to determine if fractional polynomial (FP) models characterize the relationships better than linear models. MATERIALS AND METHODS: In a cross-sectional study, structure-structure and structure-function relationships of peripapillary vessel densities were determined in 227 eyes of 143 subjects (63 control and 164 primary open-angle glaucoma eyes) who had undergone standard automated perimetry and optical coherence tomography testing within 6 months of each other, using linear and FP models...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333880/twenty-five-gauge-pars-plana-vitrectomy-in-complex-retinal-detachments-associated-with-giant-retinal-tear
#16
Vinod Kumar, Devesh Kumawat, Anju Bhari, Parijat Chandra
PURPOSE: To study the structural and functional outcomes of 25-gauge pars plana vitrectomy in giant retinal tear-associated retinal detachments. METHODS: Seventeen eyes of 17 patients with giant retinal tear, who underwent 25-gauge pars plana vitrectomy over a period of 15 months at a tertiary eye care center by a single surgeon, were recruited in this retrospective interventional study. RESULTS: Giant retinal tears were mostly traumatic (35...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28299007/correlation-between-visual-field-index-and-other-functional-and-structural-measures-in-glaucoma-patients-and-suspects
#17
Natalia A Iutaka, Rubens A Grochowski, Niro Kasahara
PURPOSE: To evaluate the correlation between visual field index (VFI) and both structural and functional measures of the optic disc in primary open angle glaucoma patients and suspects. METHODS: In this retrospective study, 162 glaucoma patients and suspects underwent standard automated perimetry (SAP), retinography, and retinal nerve fiber layer (RNFL) measurement. The optic disc was stratified according to the vertical cup/disc ratio (C/D) and sorted by the disc damage likelihood scale (DDLS)...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28291195/-optic-nerve-pathology-in-the-structure-of-diagnostic-errors-inpatients-referred-for-cataract-surgery
#18
V V Egorov, N V Savchenko, E L Sorokin, O V Danilov
AIM: to study the frequency of misdiagnosis of cataract in patients with optic nerve pathology or amblyopia and to identify its main causes. MATERIAL AND METHODS: The study enrolled 381 patients (381 eyes) wrongly diagnosed with cataract. A standard set of eye tests was performed. In-depth examination of the macular area was done through biomicroscopy with contactless aspheric lenses of 60 and 90 D. Part of the patients underwent optical coherence tomography and static perimetry as well as examination of electrical sensitivity threshold and electrical lability of the optic nerve...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28290486/creation-of-nano-eye-drops-and-effective-drug-delivery-to-the-interior-of-the-eye
#19
Yoshikazu Ikuta, Shigenobu Aoyagi, Yuji Tanaka, Kota Sato, Satoshi Inada, Yoshitaka Koseki, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
Nano eye-drops are a new type of ophthalmic treatment with increased potency and reduced side effects. Compounds in conventional eye-drops barely penetrate into the eye because the cornea, located at the surface of eye, has a strong barrier function for preventing invasion of hydrophilic or large-sized materials from the outside. In this work, we describe the utility of nano eye-drops utilising brinzolamide, a commercially available glaucoma treatment drug, as a target compound. Fabrication of the nanoparticles of brinzolamide prodrug increases the eye penetration rate and results in high drug efficacy, compared with that of commercially available brinzolamide eye-drops formulated as micro-sized structures...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28284903/ocular-and-visual-disorders-in-parkinson-s-disease-common-but-frequently-overlooked
#20
REVIEW
Merel S Ekker, Sabine Janssen, Klaus Seppi, Werner Poewe, Nienke M de Vries, Thomas Theelen, Jorik Nonnekes, Bastiaan R Bloem
Patients with Parkinson's disease (PD) often compensate for their motor deficits by guiding their movements visually. A wide range of ocular and visual disorders threatens the patients' ability to benefit optimally from visual feedback. These disorders are common in patients with PD, yet they have received little attention in both research and clinical practice, leading to unnecessary - but possibly treatable - disability. Based on a literature search covering 50 years, we review the range of ocular and visual disorders in patients with PD, and classify these according to anatomical structures of the visual pathway...
February 21, 2017: Parkinsonism & related Disorders
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