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Glaucoma structure function

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https://www.readbyqxmd.com/read/27922054/first-insight-into-the-proteome-landscape-of-the-porcine-short-posterior-ciliary-arteries-key-signalling-pathways-maintaining-physiologic-functions
#1
Caroline Manicam, Natarajan Perumal, Norbert Pfeiffer, Franz H Grus, Adrian Gericke
Short posterior ciliary arteries (sPCA) provide the major blood supply to the optic nerve head. Emerging evidence has linked structural and functional anomalies of sPCA to the pathogenesis of several ocular disorders that cause varying degrees of visual loss, particularly anterior ischaemic optic neuropathy and glaucoma. Although the functional relevance of this vascular bed is well-recognized, the proteome of sPCA remains uncharacterized. Since the porcine ocular system closely resembles that of the human's and is increasingly employed in translational ophthalmic research, this study characterized the proteome of porcine sPCA employing the mass spectrometry-based proteomics strategy...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#2
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27909796/-clinical-morphological-and-molecular-biological-characteristics-of-the-aging-eye
#3
M R R Böhm, H Thomasen, F Parnitzke, K-P Steuhl
BACKGROUND: The physiological aging of the eye is associated with loss of visual function. Age-related changes of the eye can result in ophthalmological diseases. The aim of this article is to display morphological, histological and molecular biological alterations of the aging eye. MATERIAL AND METHODS: A web-based search and review of the literature for aging of the visual system including cornea, lens, vitreous humor, retina, retinal pigment epithelium (RPE), choroidea and optic nerve were carried out...
December 1, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27898471/green-disease-in-optical-coherence-tomography-diagnosis-of-glaucoma
#4
Mohamed S Sayed, Michael Margolis, Richard K Lee
PURPOSE OF REVIEW: Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression. RECENT FINDINGS: Conditions in which OCT color coding may be falsely negative (i...
November 24, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27893102/author-response-comparison-of-local-structure-function-relationships-and-dynamic-range-in-glaucoma
#5
Arezoo Miraftabi, Navid Amini, Esteban Morales, Sharon Henry, Fei Yu, Abdolmonem Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
No abstract text is available yet for this article.
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893101/comparison-of-local-structure-function-relationships-and-dynamic-range-in-glaucoma
#6
Shuichun Wang
No abstract text is available yet for this article.
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893004/genetic-and-environmental-factors-associated-with-the-ganglion-cell-complex-in-a-healthy-aging-british-cohort
#7
Edward Bloch, Ekaterina Yonova-Doing, Eneh Jones-Odeh, Katie M Williams, Diana Kozareva, Christopher J Hammond
Importance: Measurement of ganglion cell complex (GCC) thickness may be more sensitive than current methods for glaucoma diagnosis and research. However, little is known about the factors influencing GCC thickness in the general population. Objectives: To investigate the heritability of and factors associated with GCC thickness in a healthy aging population. Design, Setting, and Participants: A cross-sectional twin study was conducted from August 27, 2014, to March 31, 2016, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pathologic conditions...
November 17, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27874246/predicting-the-intereye-asymmetry-in-functional-and-structural-damage-in-glaucoma-using-automated-pupillography
#8
Harsha L Rao, Sujatha V Kadambi, Srilakshmi Dasari, Hemanth B Reddy, Meena Palakurthy, Mohammed Riyazuddin, Narendra K Puttaiah, Zia S Pradhan, Dhanaraj A S Rao, Rohit Shetty
PURPOSE: To predict the intereye asymmetry in functional (mean deviation, MD on visual field, VF) and structural (retinal nerve fibre layer, RNFL and ganglion cell complex, GCC thickness on spectral domain optical coherence tomography, SDOCT) measurements in glaucoma using the automated pupillography parameters. METHODS: Fifty-nine subjects with a diagnosis of either glaucoma or glaucoma suspect underwent automated pupillography along with VF and SDOCT examinations...
November 22, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27865693/-point-by-point-approach-to-structure-function-correlation-of-glaucoma-on-the-ganglion-cell-complex-in-the-posterior-pole
#9
M Zeitoun
PURPOSE: To try to establish a "point by point" relationship between the local thickness of the retinal ganglion cell complex and its sensitivity. MATERIALS AND METHODS: In total, 104 glaucomatous eyes of 89 patients with a confirmed 24-2 visual field, were measured by superimposing the visual field, using imaging software, with the Wide 40° by 30° measurements of retinal ganglion cell complex obtained from the Topcon(©) 3D 2000 OCT, after upward adjustment, inversion and scaling...
November 17, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27857681/early-cytoskeletal-protein-modifications-precede-overt-structural-degeneration-in-the-dba-2j-mouse-model-of-glaucoma
#10
Gina N Wilson, Matthew A Smith, Denise M Inman, Christine M Dengler-Crish, Samuel D Crish
Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins, and microtubule-destabilizing elements, could be initiating factors in glaucoma pathogenesis. We investigated the time course of changes in protein levels and post-translational modifications in the DBA/2J mouse model of glaucoma. Using anterograde tract tracing of the retinal projection, we assessed major cytoskeletal and transported elements as a function of transport integrity in different stages of pathological progression...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27857521/global-chemical-reactivity-parameters-for-several-chiral-beta-blockers-from-the-density-functional-theory-viewpoint
#11
Mona Maria Talmaciu, Ede Bodoki, Radu Oprean
BACKGROUND AND AIM: Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices, glaucoma, and have recently become the main form of treatment of infantile hemangiomas. The aim of the present study is to calculate for 14 beta-blockers several quantum chemical descriptors in order to interpret various molecular properties such as electronic structure, conformation, reactivity, in the interest of determining how such descriptors could have an impact on our understanding of the experimental observations and describing various aspects of chemical binding of beta-blockers in terms of these descriptors...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27857487/macular-thickness-assessment-in-patients-with-glaucoma-and-its-correlation-with-visual-fields
#12
Mafalda Mota, Fernando T Vaz, Mário Ramalho, Catarina Pedrosa, Maria Lisboa, Paulo Kaku, Florindo Esperancinha
AIM: To determine the relationship between macular thickness (MT) and visual field (VF) parameters, as well as with changes in the retinal nerve fiber layer (RNFL) thickness in patients with glaucoma and ocular hypertension (OH). MATERIALS AND METHODS: Cross-sectional statistical analysis of spectral domain optical coherence tomography (SD-OCT) compared with several VF parameters (mean defect - MD and loss variance - LV), in a nonrandom sample of 70 eyes from patients with glaucoma or OH...
September 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27851990/genetic-variants-associated-with-primary-open-angle-glaucoma-in-indian-population
#13
REVIEW
Sunil Kumar, Manzoor Ahmad Malik, Sooraj K, Ramanjit Sihota, Jasbir Kaur
Glaucoma is a very common disorder of the eye wherein the disturbance of the structural or functional integrity of the optic nerve causes characteristic atrophic changes in the optic nerve, which may lead to specific visual field defects over time. Primary open angle glaucoma (POAG) is most frequent among the three principle glaucoma subtypes. With well-established role of genes like Myocilin (MYOC), Optineurin (OPTN) and WD repeat Domain 36, (WDR36), at least 29 genetic loci have been found till date to be linked to POAG...
November 13, 2016: Genomics
https://www.readbyqxmd.com/read/27844144/identification-and-functional-characterisation-of-genetic-variants-in-olfm2-in-children-with-developmental-eye-disorders
#14
R Holt, S A Ugur Iseri, A W Wyatt, D A Bax, D Gold Diaz, C Santos, S Broadgate, R Dunn, J Bruty, Y Wallis, D McMullan, C Ogilvie, D Gerrelli, Y Zhang, Nicola Ragge
Anophthalmia, microphthalmia, and coloboma are a genetically heterogeneous spectrum of developmental eye disorders and affect around 30 per 100,000 live births. OLFM2 encodes a secreted glycoprotein belonging to the noelin family of olfactomedin domain-containing proteins that modulate the timing of neuronal differentiation during development. OLFM2 SNPs have been associated with open angle glaucoma in a case-control study, and knockdown of Olfm2 in zebrafish results in reduced eye size. From a cohort of 258 individuals with developmental eye anomalies, we identified two with heterozygous variants in OLFM2: an individual with bilateral microphthalmia carrying a de novo 19p13...
November 14, 2016: Human Genetics
https://www.readbyqxmd.com/read/27843225/glaucoma-and-its-association-with-obstructive-sleep-apnea-a-narrative-review
#15
REVIEW
Aditya Chaitanya, Vijaya H Pai, Aswini Kumar Mohapatra, Ramesh S Ve
Obstructive sleep apnea (OSA) is one of the systemic risk factors for glaucoma which causes irreversible visual field (VF) damage. We reviewed the published data of all types of studies on the association between these two conditions and papers regarding functional and structural changes related to glaucomatous damage using Scopus, web of science, and PubMed databases. There is evidence that the prevalence of glaucoma is higher in OSA patients, which independent of intraocular pressure (IOP). Studies have reported thinning of retinal nerve fiber layer (RNFL), alteration of optic nerve head, choroidal and macular thickness, and reduced VF sensitivity in patients of OSA with no history glaucoma...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27820876/discriminant-function-of-optical-coherence-tomography-angiography-to-determine-disease-severity-in-glaucoma
#16
Rajesh S Kumar, Neha Anegondi, Rachana S Chandapura, Suria Sudhakaran, Sujatha V Kadambi, Harsha L Rao, Tin Aung, Abhijit Sinha Roy
Purpose: To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma. Methods: In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27820751/optic-disc-hemorrhage-in-glaucoma-pathophysiology-and-prognostic-significance
#17
Ko Eun Kim, Ki Ho Park
PURPOSE OF REVIEW: This article reviews the recent findings with regard to the pathophysiology and clinical significance of optic disc hemorrhage in glaucoma. RECENT FINDINGS: Even though the pathophysiology of disc hemorrhage has been investigated in depth, its underlying mechanism remains unclear. The key disc hemorrhage mechanisms currently under discussion are mechanical vascular disruption and associated vascular susceptibilities. Recent technical advances in spectral-domain optical coherence tomography have yielded more compelling evidence of mechanical vascular disruption behind the pathogenesis of disc hemorrhage in glaucoma...
November 4, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27790380/aqueous-humor-outflow-structure-and-function-imaging-at-the-bench-and-bedside-a-review
#18
Alex S Huang, Chirayu Mohindroo, Robert N Weinreb
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed...
August 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27760009/relationship-between-visual-field-changes-and-optical-coherence-tomography-measurements-in-advanced-open-angle-glaucoma
#19
Snezhina S Kostianeva, Marieta I Konareva-Kostianeva, Marin A Atanassov
AIM: To assess relationships between functional changes in visual field and structural changes in advanced open-angle glaucoma (OAG) found using spectral-domain optical coherence tomography (SD-OCT). METHODS: Thirty-one eyes of 25 patients with OAG were included in this study. Besides the routine ophthalmological exam the patients underwent standard automated perimetry (SAP) (Humphrey Field Analyzer) and SD-OCT (RTVue-100) performed within 6 months. The global perimetric indices in the study group were as follows: mean deviation (MD) 12...
September 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/27683897/age-related-changes-in-axonal-and-mitochondrial-ultrastructure-and-function-in-white-matter
#20
Katharine E Stahon, Chinthasagar Bastian, Shelby Griffith, Grahame J Kidd, Sylvain Brunet, Selva Baltan
UNLABELLED: The impact of aging on CNS white matter (WM) is of general interest because the global effects of aging on myelinated nerve fibers are more complex and profound than those in cortical gray matter. It is important to distinguish between axonal changes created by normal aging and those caused by neurodegenerative diseases, including multiple sclerosis, stroke, glaucoma, Alzheimer's disease, and traumatic brain injury. Using three-dimensional electron microscopy, we show that in mouse optic nerve, which is a pure and fully myelinated WM tract, aging axons are larger, have thicker myelin, and are characterized by longer and thicker mitochondria, which are associated with altered levels of mitochondrial shaping proteins...
September 28, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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