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Glaucoma structure function

C Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic
Mesenchymal stem cells (MSCs) were, due to their immunomodulatory and pro-angiogenic characteristics, extensively explored as new therapeutic agents in cell-based therapy of uveitis, glaucoma, retinal and ocular surface diseases.Since it was recently revealed that exosomes play an important role in biological functions of MSCs, herewith we summarized current knowledge about the morphology, structure, phenotype and functional characteristics of MSC-derived exosomes emphasizing their therapeutic potential in the treatment of eye diseases...
May 18, 2018: Advances in Experimental Medicine and Biology
Mohammad Harun-Or-Rashid, Nate Pappenhagen, Peter G Palmer, Matthew A Smith, Victoria Gevorgyan, Gina N Wilson, Samuel D Crish, Denise M Inman
Axon degeneration can arise from metabolic stress, potentially a result of mitochondrial dysfunction or lack of appropriate substrate input. In this study, we investigated whether the metabolic vulnerability observed during optic neuropathy in the DBA/2J (D2) model of glaucoma is due to dysfunctional mitochondria or impaired substrate delivery to axons, the latter based on our observation of significantly decreased glucose and monocarboxylate transporters in D2 optic nerve (ON), human ON, and mice subjected to acute glaucoma injury...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Zhongcui Sun, Hua Gao, Min Wang, Qing Chang, Gezhi Xu
PURPOSE: To describe a foveomacular retinoschisis that has not been described. METHODS: Patients with foveomacular retinoschisis were included. Exclusion criteria included refractive error over -6.00 diopters, presence of posterior staphyloma, positive RS1-gene mutation, family history of retinoschisis, optic disk abnormalities, or glaucoma. Vitrectomy was performed on eyes with functional or structural deterioration. RESULTS: Seventeen eyes from 10 patients (15-30 years old, 8 females and 2 males) with foveoschisis were recruited, with bilateral involvement in 7 patients and unilateral in 3 patients...
May 2, 2018: Retina
Anna K van Koeverden, Zheng He, Christine T O Nguyen, Algis J Vingrys, Bang V Bui
High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure - intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply...
May 8, 2018: Scientific Reports
Gokulan Ratnarajan, Jasleen K Jolly, Imran H Yusuf, John F Salmon
PURPOSE: To determine the functional and structural effects of trabeculectomy surgery on patients with advanced glaucoma and central visual field defects in the early post-operative period. METHODS: Thirty consecutive adult subjects with advanced glaucoma requiring trabeculectomy surgery and an established visual field defect within 10° of fixation underwent microperimetry (MAIA MP-1, CenterVue, Padova, Italy) and optic disc optical coherence tomography (OCT) imaging (Spectralis, Heidelberg Engineering, Germany) pre-operatively, and 1 month and 3 months following trabeculectomy surgery...
April 30, 2018: Eye
Bo Ram Seol, Byeong Wook Yoo, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the changes in macular ganglion cell-inner plexiform layer (GCIPL) defect between stable and progression primary open-angle glaucoma (POAG) groups. STUDY DESIGN: Retrospective observational study. METHODS: A total of 100 POAG eyes with localized retinal nerve fiber layer (RNFL) defect and corresponding macular GCIPL defect were selected for this study. Glaucoma progression was defined by either structural or functional deterioration...
April 25, 2018: Japanese Journal of Ophthalmology
Junki Kwon, Kyung Rim Sung, Jaehyuck Jo, Sung Ho Yang
PURPOSE: To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS: Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and central corneal thickness were measured at the time of glaucoma diagnosis. Three IOP measurements, i.e., uncorrected IOP (UC IOP) and corrected IOP calculated by applying the Kohlhaas (CK IOP) and Ehlers (CE IOP) formulas, were used...
April 20, 2018: Current Eye Research
Elmira Baghdasaryan, Tudor C Tepelus, Laura A Vickers, Ping Huang, Vikas Chopra, SriniVas R Sadda, Olivia L Lee
PURPOSE: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes. METHODS: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Germany)...
April 7, 2018: Ophthalmic Research
Rodrigo Abreu-Gonzalez, Marta Gonzalez-Hernandez, Cristina Pena-Betancor, Paloma Rodriguez-Esteve, Manuel Gonzalez De La Rosa
PURPOSE: To evaluate the specificity of new perimetric indices based on harmony, alone and in combination with structural data, for glaucoma detection. METHODS: In this prospective observational cross-sectional study, one eye of 105 healthy subjects and 97 early and suspect glaucomas were sequentially included and examined with Cirrus optical coherence tomography, twice with OCULUS Smartfield perimeter (SPARK strategy) and twice with Humphrey Analyzer (24-2 SITA-Fast) at the Ophthalmology Department from the University Hospital La Candelaria...
April 1, 2018: European Journal of Ophthalmology
Chunwei Zhang, Andrew J Tatham, Fábio B Daga, Alessandro A Jammal, Felipe A Medeiros
PURPOSE: To investigate the relationship between progression assessed by the visual field guided progression analysis (GPA) and rates of structural and functional change in glaucoma eyes. METHODS: This was a longitudinal observational study of 135 eyes of 97 patients with glaucoma followed for an average of 3.5 ± 0.9 years. All patients had standard automated perimetry (SAP) and retinal nerve fiber layer (RNFL) analysis with spectral domain optical coherence tomography (SDOCT), with an average of 6...
April 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Carlos Gustavo De Moraes
No abstract text is available yet for this article.
April 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Nayuta Yoshioka, Barbara Zangerl, Jack Phu, Agnes Y J Choi, Sieu K Khuu, Katherine Masselos, Michael P Hennessy, Michael Kalloniatis
Purpose: To investigate the effect of stimulus size and disease status on the structure-function relationship within the central retina, we correlated the differential light sensitivity (DLS) with Goldmann stimulus size I to V (GI-V) and optical coherence tomography (OCT) derived in vivo ganglion cell count per stimulus area (GCc) within the macular area in normal subjects and patients with early glaucoma. Methods: Humphrey Field Analyzer 10-2 visual field data with GI through V and Spectralis OCT macular ganglion cell layer (GCL) thickness measurements were collected from normal and early glaucoma cohorts including 25 subjects each...
April 1, 2018: Investigative Ophthalmology & Visual Science
Katia Novak Lauš, Željka Tomić, Marija Šimić Prskalo, Renata Iveković, Valentina Lacmanović Lončar, Ivanka Petric Vicković, Veljko Rogošić, Teo Tomić, Zrinko Prskalo
The progressive nature of glaucoma suggests it should be possible to detect structural changes such as retinal nerve fiber layer (RNFL) thickness loss before the condition becomes clinically apparent with visual field (VF) impairment. Therefore, the aim was to analyze RNFL thickness and VF changes in study groups with unilateral exfoliation syndrome (XFS), bilateral XFS and bilateral exfoliative glaucoma (XFG), and compare it with controls. The study included 114 subjects (228 eyes) divided into 4 groups according to the presence of exfoliation: 30 subjects with unilateral XFS (30 with clinically visible XFS and 30 fellow eyes), 24 subjects (48 eyes) with bilateral XFS, 28 (56 eyes) subjects with bilateral XFG, and control group (32 subjects)...
December 2017: Acta Clinica Croatica
Raymond P Najjar, Sourabh Sharma, Eray Atalay, Annadata V Rukmini, Christopher Sun, Jing Zhan Lock, Mani Baskaran, Shamira A Perera, Rahat Husain, Ecosse Lamoureux, Joshua J Gooley, Tin Aung, Dan Milea
PURPOSE: To evaluate the ability of chromatic pupillometry to reveal abnormal pupillary responses to light in patients with early-stage primary open-angle glaucoma (POAG) and to test whether the degree of pupillometric impairment correlates with structural hallmarks of optic nerve damage in the disease. DESIGN: Cross-sectional study. PARTICIPANTS: Forty-six patients with early-stage POAG (63.4±8.3 years, 63% male, 87% ethnic-Chinese) and 90 age-matched healthy controls (61...
March 21, 2018: Ophthalmology
Youngseok Song, Hiroshi Ishikawa, Mengfei Wu, Yu-Ying Liu, Katie A Lucy, Fabio Lavinsky, Mengling Liu, Gadi Wollstein, Joel S Schuman
PURPOSE: Previously, we introduced a state-based 2-dimensional continuous-time hidden Markov model (2D CT HMM) to model the pattern of detected glaucoma changes using structural and functional information simultaneously. The purpose of this study was to evaluate the detected glaucoma change prediction performance of the model in a real clinical setting using a retrospective longitudinal dataset. DESIGN: Longitudinal, retrospective study. PARTICIPANTS: One hundred thirty-four eyes from 134 participants diagnosed with glaucoma or as glaucoma suspects (average follow-up, 4...
March 20, 2018: Ophthalmology
Rafael Lacerda Furlanetto, Sergio Henrique Teixeira, Carolina Pelegrini Barbosa Gracitelli, Claudio Luiz Lottenberg, Fabiano Emori, Michel Michelan, Edson Amaro, Augusto Paranhos
PURPOSE: To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. METHODS: In this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluation; and 3T MRI...
2018: PloS One
Rebecca Daly, Pankaj Kumar Agarwal
AIMS: Patient held records are becoming more commonly used in healthcare, particularly in chronic diseases like glaucoma. There is a lack of evidence to support their use, however. This study examines the change in knowledge scores within a group following the introduction of a newly designed glaucoma logbook. METHODS: This analysis uses a test and retest method where patients undergoing treatment for glaucoma or ocular hypertension were assessed using a validated knowledge questionnaire...
March 21, 2018: Journal of Glaucoma
Millicent Bore, Nikhil Choudhari, Sunita Chaurasia
PURPOSE: To report the intricacies of managing complications that arose out of cosmetic iris implants (BrightOcular) placement. DESIGN: Interventional case report. METHODS: A thirty-year-old gentleman presented with complaint of progressive loss of vision after having cosmetic iris implant surgery to change his eye colour. He then developed raised intraocular pressures and had a right eye trabeculectomy conducted with the implants in situ...
March 21, 2018: International Ophthalmology
Zia S Pradhan, Shivani Dixit, Shruthi Sreenivasaiah, Harsha L Rao, Jayasree P Venugopal, Sathi Devi, Carroll A B Webers
PURPOSE: To study sectoral vessel density (VD) and structural alterations in the peripapillary and parafoveal hemiretina corresponding to perimetrically intact regions of glaucomatous eyes with hemifield defects and to compare these with healthy eyes using optical coherence tomography. METHODS: This cross-sectional study included 37 eyes with open-angle glaucoma having visual fields (VF) defects restricted to one hemifield and 45 age-matched controls. Peripapillary VD and retinal nerve fiber layer (RNFL) thickness were measured in 8 sectors...
March 19, 2018: Journal of Glaucoma
Xiao-Ling Yang, Yolandi van der Merwe, Jeffrey Sims, Carlos Parra, Leon C Ho, Joel S Schuman, Gadi Wollstein, Kira L Lathrop, Kevin C Chan
Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma, their effects on glaucoma pathogenesis remain unclear. This study examined the onset and progression of glaucomatous changes to ocular anatomy and physiology, structural and physiological brain integrity, and visuomotor behavior in the DBA/2J mice via non-invasive tonometry, multi-parametric magnetic resonance imaging (MRI) and optokinetic assessments from 5 to 12 months of age. Using T2-weighted MRI, diffusion tensor MRI, and manganese-enhanced MRI, increasing IOP elevation at 9 and 12 months old coincided with anterior chamber deepening, altered fractional anisotropy and radial diffusivity of the optic nerve and optic tract, as well as reduced anterograde manganese transport along the visual pathway respectively in the DBA/2J mice...
March 15, 2018: Scientific Reports
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