keyword
MENU ▼
Read by QxMD icon Read
search

Glaucoma structure function

keyword
https://www.readbyqxmd.com/read/29140817/new-developments-in-optical-coherence-tomography-imaging-for-glaucoma
#1
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. RECENT FINDINGS: Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29119021/comparison-between-the-correlations-of-retinal-nerve-fiber-layer-thickness-measured-by-spectral-domain-optical-coherence-tomography-and-visual-field-defects-in-standard-automated-white-on-white-perimetry-versus-pulsar-perimetry
#2
Maged Alnawaiseh, Lisann Hömberg, Nicole Eter, Verena Prokosch
Purpose: To compare the structure-function relationships between retinal nerve fiber layer thickness (RNFLT) and visual field defects measured either by standard automated perimetry (SAP) or by Pulsar perimetry (PP). Materials and Methods: 263 eyes of 143 patients were prospectively included. Depending on the RNFLT, patients were assigned to the glaucoma group (group A: RNFL score 3-6) or the control group (group B: RNFL score 0-2). Structure-function relationships between RNFLT and mean sensitivity (MS) measured by SAP and PP were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118497/comparing-ganglion-cell-inner-plexiform-layer-thickness-with-focal-and-global-responses-on-multifocal-electroretinogram-in-glaucoma
#3
Aparna Rao, Rohit V Chandrashekhar, Debananda Padhy, Sujoy Mukherjee, Gopinath Das, Sarada Sarangi
BACKGROUND: The aim of this study was to evaluate responses on multifocal electroretinogram (mfERG) with ganglion cell-inner plexiform layer (GCIPL) thickness on cirrus spectral-domain optical coherence tomography (SD-OCT) in glaucoma. METHODS: All diagnosed glaucoma patients attending glaucoma services at our institute from November 2012 to April 2013 were screened for this observational hospital-based study. Controls included patients attending our outpatient services for general eye checkup...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29116211/usefulness-of-10-2-matrix-frequency-doubling-technology-perimetry-for-detecting-central-visual-field-defects-in-preperimetric-glaucoma-patients
#4
Younhea Jung, Hae-Young L Park, Yi Ryeung Park, Chan Kee Park
It is generally acknowledged that structural loss can precede functional loss in some patients with early glaucoma. However, conventional standard automated perimetry (SAP) has limitations in the detection of functional loss, especially in the macular area. This study explores visual field loss in the macular areas of patients with preperimetric glaucoma exhibiting structural thinning in the area by examining the correlations between the ganglion cell-inner plexiform layer (GCIPL) and the results of matrix frequency-doubling technology (FDT) 10-2 tests...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29106382/angiopoietin-1-is-required-for-schlemm-s-canal-development-in-mice-and-humans
#5
Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto, Xiaorong Liu, Simon Wm John, Jamie E Craig, Jing Jin, Terri L Young, Susan E Quaggin
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure...
November 6, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29098286/development-of-an-18-item-measure-of-symptom-burden-in-patients-with-glaucoma-from-the-collaborative-initial-glaucoma-treatment-study-s-symptom-and-health-problem-checklist
#6
David C Musch, Michelle E Tarver, Matt J Goren, Nancy K Janz
Importance: Administration of a brief questionnaire to evaluate glaucoma symptoms would lend useful information for patient care. Objectives: To develop a shortened glaucoma symptom measure based on the Collaborative Initial Glaucoma Treatment Study (CIGTS) Symptom and Health Problem Checklist (SHPC) and evaluate its psychometric properties. Design, Setting, and Participants: This measure development study evaluated the factor structure of the 43-item SHPC that was obtained from CIGTS participants at baseline and every 6 months thereafter...
November 2, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29090107/optic-disc-image-subtraction-as-an-aid-to-detect-glaucoma-progression
#7
Navid Amini, Reza Alizadeh, Nucharee Parivisutt, EunAh Kim, Kouros Nouri-Mahdavi, Joseph Caprioli
PURPOSE: To present a digital image subtraction technique to alert clinicians to signs of glaucomatous optic disc progression. METHODS: Ninety-two glaucomatous eyes (65 patients) were included. Thirty-three eyes were identified as progressive and 59 as stable based on comparison of baseline and follow-up stereoscopic disc photographs by three masked glaucoma specialists. The disc images were aligned and converted to gray scale and underwent histogram matching to enhance contrast and account for illumination differences...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29082108/goldmann-v-standard-automated-perimetry-underestimates-central-visual-sensitivity-in-glaucomatous-eyes-with-increased-axial-length
#8
Mieko Yanagisawa, Hiroshi Murata, Masato Matsuura, Yuri Fujino, Kazunori Hirasawa, Ryo Asaoka
PURPOSE: To investigate the effect of axial length (AL) on the structure-function relationship between retinal nerve fiber layer (RNFL) thickness measurements and visual field (VF) sensitivity measured with Goldmann III and V. METHOD: There were 85 eyes of 85 patients with primary open angle glaucoma included in the current study. Optical coherence tomography and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III and V targets were carried out in all patients...
October 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29082038/phenotypic-description-of-the-spanish-multicentre-genetic-glaucoma-group-cohort
#9
Elena Milla, Maria José Gamundi, Susana Duch, Jose Rios, Miguel Carballo, Emeigg Study Group
INTRODUCTION: The aim of the study was to make a phenotypic description of the Spanish multicentre glaucoma group cohort of patients. DESIGN: Retrospective, observational, multicentre, cohort study. MATERIAL AND METHODS: The clinical charts of 152 patients with hereditary glaucoma from18 Spanish eye centres were reviewed in order to make an epidemiologic description of the type of glaucoma and associated factors. True hereditary cases were compared with familiar cases according to the Gong et al...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29074388/functional-assessment-of-the-aqueous-humour-distal-outflow-pathways-in-bovine-eyes-using-time-of-flight-magnetic-resonance-tomography
#10
Thomas Wecker, Christian van Oterendorp, Wilfried Reichardt
The major part of the aqueous humor leaves the eye through the "conventional outflow pathway", consisting of the trabecular meshwork, Schlemm's canal, collector channels, an intrasceral plexus and the episcleral veins. While the trabecular meshwork is well characterized, little is known about anatomical and functional features of the peripheral outflow tract beyond Schlemm's canal. The emergence of minimally-invasive glaucoma surgery directly targeting the outflow resistance in the trabecular meshwork has elicited growing interest in these structures...
October 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29064608/diffuse-brain-damage-in-normal-tension-glaucoma
#11
Antonio Giorgio, Jian Zhang, Francesco Costantino, Nicola De Stefano, Paolo Frezzotti
Brain changes within and beyond the visual system have been demonstrated in primary open angle glaucoma (POAG), the most common type of glaucoma. These changes have been often interpreted as a neurodegenerative process due, at least partially, to the raised intraocular pressure (IOP). In this context, normal tension glaucoma (NTG), a form of POAG with IOP <21 mm Hg despite the typical glaucomatous findings, represents the most suitable model of glaucoma to test the validity of this hypothesis. We acquired multimodal brain MRI in NTG patients (n = 17) and compared them with demographically matched groups of POAG patients with raised IOP (n = 17) and normal controls (NC, n = 29)...
October 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29062772/structure-function-relationship-comparison-between-retinal-nerve-fibre-layer-and-bruch-s-membrane-opening-minimum-rim-width-in-glaucoma
#12
Lukas Reznicek, Sophie Burzer, Andrea Laubichler, Ali Nasseri, Chris P Lohmann, Nikolaus Feucht, Michael Ulbig, Mathias Maier
AIM: To evaluate and compare structural optical coherence tomography (OCT)-based parameters, such as Bruch's membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations. METHODS: Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049729/myocilin-regulates-metalloprotease-2-activity-through-interaction-with-timp3
#13
Myung Kuk Joe, Raquel L Lieberman, Naoki Nakaya, Stanislav I Tomarev
Purpose: To elucidate functions of wild-type myocilin, a secreted glycoprotein associated with glaucoma. Methods: Lysates of mouse eyes were used for immunoprecipitation with affinity-purified antibodies against mouse myocilin. Shotgun proteomic analysis was used for the identification of proteins interacting with myocilin. Colocalization of myocilin and tissue inhibitor of metalloproteinases 3 (TIMP3) in different eye structures was investigated by a multiplex fluorescent in situ hybridization and immunofluorescent labeling with subsequent confocal microscopy...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049726/comparison-of-sectoral-structure-function-relationships-in-glaucoma-vessel-density-versus-thickness-in-the-peripapillary-retinal-nerve-fiber-layer
#14
COMPARATIVE STUDY
Kimikazu Sakaguchi, Tomomi Higashide, Sachiko Udagawa, Shinji Ohkubo, Kazuhisa Sugiyama
Purpose: To compare the sectoral structure-function relationships in glaucoma between two structural parameters, vessel density (VD) and thickness, in the peripapillary retinal nerve fiber layer (RNFL). Methods: Optical coherence tomography (OCT) angiography (AngioVue/RTVue-XR) for VD and OCT (RS-3000) for peripapillary RNFL thickness were performed in 129 eyes from 129 subjects (94 glaucoma, 17 glaucoma suspects, and 18 normal eyes). Humphrey visual field (VF) tests were performed using a SITA standard 24-2 program...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049074/physiology-and-role-of-intraocular-pressure-in-contemporary-anesthesia
#15
Dermot J Kelly, Sinéad M Farrell
More than 26 million Americans suffer with cataracts, and with 3.6 million cataract extractions performed annually in the United States, it is the most common surgical procedure. The integrity of the delicate structures of the eye that mediate vision is dependent on the intraocular pressure (IOP). Yet, IOP acts to compress the vessels within the globe-akin to a Starling resistor-and is a key component that determines the ocular perfusion pressure, defined as the difference between arterial pressure and IOP...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29016521/glaucoma-diagnostic-capabilities-of-foveal-avascular-zone-parameters-using-optical-coherence-tomography-angiography-according-to-visual-field-defect-location
#16
Junki Kwon, Jaewan Choi, Joong Won Shin, Jiyun Lee, Michael S Kook
PURPOSE: To assess the diagnostic ability of foveal avascular zone (FAZ) parameters to discriminate glaucomatous eyes with visual field defects (VFDs) in different locations (central vs. peripheral) from normal eyes. PATIENTS AND METHODS: Totally, 125 participants were separated into three groups: normal (n=45), glaucoma with peripheral VFD (PVFD, n=45), and glaucoma with central VFD (CVFD, n=35). The FAZ area, perimeter, and circularity and parafoveal vessel density were calculated from optical coherence tomography angiography images...
October 9, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28973333/pattern-recognition-analysis-reveals-unique-contrast-sensitivity-isocontours-using-static-perimetry-thresholds-across-the-visual-field
#17
Jack Phu, Sieu K Khuu, Lisa Nivison-Smith, Barbara Zangerl, Agnes Yiu Jeung Choi, Bryan W Jones, Rebecca L Pfeiffer, Robert E Marc, Michael Kalloniatis
Purpose: To determine the locus of test locations that exhibit statistically similar age-related decline in sensitivity to light increments and age-corrected contrast sensitivity isocontours (CSIs) across the central visual field (VF). We compared these CSIs with test point clusters used by the Glaucoma Hemifield Test (GHT). Methods: Sixty healthy observers underwent testing on the Humphrey Field Analyzer 30-2 test grid using Goldmann (G) stimulus sizes I-V. Age-correction factors for GI-V were determined using linear regression analysis...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28966635/modulation-of-valosin-containing-protein-by-kyoto-university-substances-kus-as-a-novel-therapeutic-strategy-for-ischemic-neuronal-diseases
#18
REVIEW
Masayuki Hata, Hanako Ohashi Ikeda
Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate (ATP) depletion and subsequent induced endoplasmic reticulum (ER) stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity...
August 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28939691/5-year-disease-progression-of-patients-across-the-glaucoma-spectrum-assessed-by-structural-and-functional-tools
#19
Natasha Gautam Seth, Sushmita Kaushik, Savleen Kaur, Srishti Raj, Surinder Singh Pandav
BACKGROUND: Assessment of spectral-domain optical coherence tomography (SD-OCT) compared with visual fields, to detect progression across the glaucoma spectrum. METHODS: In this study, adult glaucoma suspects and patients, with baseline retinal nerve fibre layer (RNFL) thickness on SD-OCT and reliable visual field (VF) tests on Humphrey Field Analyser (HFA) prior to March 2010, were recruited. Functional and structural progression over at least 5 years was compared using Glaucoma Progression Analysis (GPA) and VF index (VFI) on HFA and Guided Progression Analysis (GPA-OCT) on SD-OCT, respectively...
September 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28911203/mutations-of-conserved-non-coding-elements-of-pitx2-in-patients-with-ocular-dysgenesis-and-developmental-glaucoma
#20
Meredith E Protas, Eric Weh, Tim Footz, Jay Kasberger, Scott C Baraban, Alex V Levin, L Jay Katz, Robert Ritch, Michael A Walter, Elena V Semina, Douglas B Gould
Mutations in FOXC1 and PITX2 constitute the most common causes of ocular anterior segment dysgenesis (ASD), and confer a high risk for secondary glaucoma. The genetic causes underlying ASD in approximately half of patients remain unknown, despite many of them being screened by whole exome sequencing. Here, we performed whole genome sequencing on DNA from two affected individuals from a family with dominantly inherited ASD and glaucoma to identify a 748-kb deletion in a gene desert that contains conserved putative PITX2 regulatory elements...
September 15, 2017: Human Molecular Genetics
keyword
keyword
61432
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"