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OCT for glaucoma optic nerve

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https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#1
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29643463/diagnostic-capacity-of-sd-oct-segmented-ganglion-cell-complex-versus-retinal-nerve-fiber-layer-analysis-for-congenital-glaucoma
#2
Laura Morales-Fernandez, Maria Jimenez-Santos, Jose M Martinez-de-la-Casa, Ruben Sanchez-Jean, Maria Nieves, Federico Saenz-Frances, Sofia Garcia-Saenz, Lucia Perucho, Rosario Gomez-de-Liaño, Julian Garcia-Feijoo
PURPOSE: To compare the diagnostic performance of circumpapillary retinal nerve fiber layer (cpRNFL) analysis versus segmented ganglion cell complex analysis both by spectral-domain optical coherence tomography (SD-OCT) in children with primary congenital glaucoma (PCG). METHODS: Participants were 40 children diagnosed with PCG and 60 healthy children. Ophthalmological data collected (for one eye per child) were cup-disc ratio (C/D) and axial length (AL). SD-OCT with automated segmentation was used to measure the thicknesses and volumes of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL)...
April 12, 2018: Eye
https://www.readbyqxmd.com/read/29629238/validation-of-the-unc-oct-index-for-the-diagnosis-of-early-glaucoma
#3
Jean-Claude Mwanza, Gary Lee, Donald L Budenz, Joshua L Warren, Michael Wall, Paul H Artes, Thomas M Callan, John G Flanagan
Purpose: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. Methods: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than -4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29621263/wide-scan-imaging-with-swept-source-optical-coherent-tomography-for-glaucoma-diagnosis
#4
Eun Hee Hong, Yong Un Shin, Min Ho Kang, Heeyoon Cho, Mincheol Seong
PURPOSE: To determine glaucoma-discriminating abilities of macular and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements of wide scan (12X9mm) using swept-source optical coherence tomography (SS-OCT) compared to measurements of standard macula and disc scans (6 X 6 mm). METHODS: This retrospective chart review study included 60 glaucomatous and 62 healthy eyes of total 122 subjects who visited a glaucoma clinic and were examined with wide, standard macula, and standard disc scans of SS-OCT (DRI-OCT-1 Atlantis; Topcon Inc...
2018: PloS One
https://www.readbyqxmd.com/read/29613982/association-between-the-deep-layer-microvasculature-dropout-and-the-visual-field-damage-in-glaucoma
#5
Min Hee Suh, Jun Woo Park, Hae Rang Kim
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4)...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29602236/evaluating-glaucomatous-abnormality-in-peripapillary-optical-coherence-tomography-enface-visualisation-of-the-retinal-nerve-fibre-layer-reflectance
#6
Bright S Ashimatey, Brett J King, Stephen A Burns, William H Swanson
PURPOSE: Optical coherence tomography (OCT) enface visualisation of the retinal nerve fibre layer (RNFL) reflectance has been found to have some advantages over retinal thickness measures. However, it is not yet clear how abnormalities on enface images relate to findings of abnormalities from other clinical measures such as the circumpapillary retinal nerve fibre layer thickness (cRNFLT). We developed a technique to analyse the RNFL reflectance on the OCT enface images, and to investigate its relation with the cRNFLT...
March 30, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29590684/-morphological-and-quantitative-changes-in-retinal-and-optic-nerve-vessels-in-experimental-glaucoma-model-with-elevated-iop-for-7-weeks
#7
Carolina Mann, Fabian Anders, Hanhan Liu, Katrin Brockhaus, Aiwei Liu, Franz H Grus, Norbert Pfeiffer, Solon Thanos, Verena Prokosch
INTRODUCTION: Glaucoma is characterised by progressive loss of retinal ganglion cells and axons. Experimental research has concentrated on understanding the pathophysiological mechanisms involved in glaucomatous damage. It is still a matter of debate whether neurons or capillaries are primarily damaged by elevated intraocular pressure (IOP). The aim of this study was to detect IOP-induced vascular changes in the vessels of the optic nerve head and the main vessels of the retina in vivo...
March 28, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29582810/evaluation-of-macular-ganglion-cell-analysis-compared-to-retinal-nerve-fiber-layer-thickness-for-preperimetric-glaucoma-diagnosis
#8
Sushmita Kaushik, Pankaj Kataria, Vaibhav Jain, Gunjan Joshi, Srishti Raj, Surinder Singh Pandav
Purpose: To compare the diagnostic ability of the ganglion cell analysis (GCA) and retinal nerve fiber layer (RNFL) protocol on optical coherence tomography (OCT), to diagnose preperimetric glaucoma. Methods: A prospective, cross-sectional study of 275 adult patients including 47 early glaucoma (mean deviation better than -6.0 D), 150 glaucoma suspects (106 with suspicious discs and 44 ocular hypertensive (OHT), and 78 normal controls was done. Eligible participants were scanned with the spectral domain CirrusTM OCT (Carl Zeiss Meditec, Dublin, CA)...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580976/inter-eye-asymmetry-of-optical-coherence-tomography-angiography-vessel-density-in-bilateral-glaucoma-glaucoma-suspect-and-healthy-eyes
#9
Huiyuan Hou, Sasan Moghimi, Linda M Zangwill, Takuhei Shoji, Elham Ghahari, Patricia Isabel C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma suspect, and mild to moderate glaucoma subjects, and its potential utility for early detection of glaucomatous damage. DESIGN: Cross-sectional study. METHODS: 153 subjects including 55 healthy, 32 glaucoma suspect, and 66 glaucoma subjects enrolled in the Diagnostic Innovations in Glaucoma Study(DIGS). Vessel density was obtained from optical coherence tomography angiography (OCT-A) macular and optic nerve head scans...
March 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29575745/evaluation-of-two-dimensional-bruch-s-membrane-opening-minimum-rim-area-for-glaucoma-diagnostics-in-a-large-patient-cohort
#10
Philip Enders, Werner Adler, David Kiessling, Vincent Weber, Friederike Schaub, Manuel M Hermann, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
PURPOSE: To characterize the two-dimensional parameter Bruch's membrane opening minimum rim area (BMO-MRA) in spectral domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO-MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. METHODS: Case-control, cross-sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD-OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination...
March 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29570721/structural-and-functional-analyses-of-the-optic-nerve-and-lateral-geniculate-nucleus-in-glaucoma
#11
Rafael Lacerda Furlanetto, Sergio Henrique Teixeira, Carolina Pelegrini Barbosa Gracitelli, Claudio Luiz Lottenberg, Fabiano Emori, Michel Michelan, Edson Amaro, Augusto Paranhos
PURPOSE: To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. METHODS: In this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluation; and 3T MRI...
2018: PloS One
https://www.readbyqxmd.com/read/29557834/anterior-chamber-angle-tissue-as-an-incidental-optical-coherence-tomography-finding-in-a-large-healthy-caucasian-child-population
#12
José Ignacio Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Bachar Kudsieh, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Julián García-Feijóo
PURPOSE: To describe the presence of anterior chamber angle (ACA) tissue as an incidental optical coherence tomography (OCT) finding in healthy children. METHODS: For this cross-sectional study, we reviewed Fourier domain OCT images obtained in 422 children as candidates for inclusion in a prior study who visited our clinic for a routine vision test. The presence of angle tissue was assessed in the nasal and temporal quadrants. On tomographies showing angle tissue, several measurements were made including ACA width and trabecular meshwork (TM) length and size...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29557831/glaucoma-features-in-an-east-african-population-a-six-year-cohort-study-of-older-adults-in-nakuru-kenya
#13
Andrew Bastawrous, Wanjiku Mathenge, John Buchan, Fatima Kyari, Tunde Peto, Hillary Rono, Helen A Weiss, David Macleod, Allen Foster, Matthew Burton, Hannah Kuper
PURPOSE: Glaucoma is a leading cause of blindness in people of African descent. Minimal data is available from African population-based cohort studies. The primary aims of this study were to describe the normative distribution of glaucoma features to enable glaucoma classification and to assess risk factors for those with glaucoma at follow-up among people aged ≥50 years in Kenya. MATERIALS AND METHODS: Random cluster sampling with probability proportionate to size was used to select a representative cross-sectional sample of adults aged ≥50 years in 2007-8 in Nakuru District, Kenya...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29555383/mapping-the-thickness-changes-on-retinal-layers-segmented-by-spectral-domain-optical-coherence-tomography-using-the-posterior-pole-program-in-glaucoma
#14
J J García-Medina, M Del-Rio-Vellosillo, A Palazón-Cabanes, M Tudela-Molino, C Gómez-Molina, A Guardiola-Fernández, M P Villegas-Pérez
OBJECTIVES: To evaluate changes in retinal layers of the macula (mRLs) using OCT posterior pole program (PPP) in primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study included 128 patients with POAG and 103 healthy controls who had PPP maps (macular grid 8×8) drawn by SD-OCT. Only one eye per patient was studied. The 9 mRLs were automatically segmented by prototype software, obtaining: a macular retinal nerve fibre layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform+nuclear layer, photoreceptor layer, retinal pigment epithelium (RPE), outer retina and RPE+outer retina...
March 16, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29550000/longitudinal-changes-of-optic-nerve-head-and-peripapillary-structure-during-childhood-myopia-progression-on-oct-boramae-myopia-cohort-study-report-1
#15
Martha Kim, Ho-Kyung Choung, Kyoung Min Lee, Sohee Oh, Seok Hwan Kim
PURPOSE: To delineate longitudinal changes in the optic nerve head (ONH) and peripapillary structure during myopia progression in childhood using spectral-domain (SD) OCT and to explore the factors associated with myopic ONH and peripapillary changes. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy children with myopia (46 eyes). METHODS: The participants underwent fundus photography, SD OCT, and axial length (AXL) measurements every 6 months for 2 years...
March 14, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29544962/positional-change-of-optic-nerve-head-vasculature-during-axial-elongation-as-evidence-of-lamina-cribrosa-shifting-boramae-myopia-cohort-study-report-2
#16
Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
PURPOSE: To investigate the positional change of central retinal vasculature and vascular trunk to deduce the change in the lamina cribrosa (LC) during axial elongation. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy myopic children (46 eyes). METHODS: Participants had undergone a full ophthalmologic examination and axial length measurement every 6 months for 2 years. Using spectral-domain OCT, circle scans centered around the optic disc in the glaucoma progression analysis mode, which enabled capturing of the same positions throughout the entire study period, and enhanced depth imaging of the deep optic nerve head complex were performed...
March 12, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29541497/shared-hole-graph-search-with-adaptive-constraints-for-3d-optic-nerve-head-optical-coherence-tomography-image-segmentation
#17
Kai Yu, Fei Shi, Enting Gao, Weifang Zhu, Haoyu Chen, Xinjian Chen
Optic nerve head (ONH) is a crucial region for glaucoma detection and tracking based on spectral domain optical coherence tomography (SD-OCT) images. In this region, the existence of a "hole" structure makes retinal layer segmentation and analysis very challenging. To improve retinal layer segmentation, we propose a 3D method for ONH centered SD-OCT image segmentation, which is based on a modified graph search algorithm with a shared-hole and locally adaptive constraints. With the proposed method, both the optic disc boundary and nine retinal surfaces can be accurately segmented in SD-OCT images...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29523993/structural-changes-of-macular-inner-retinal-layers-in-early-normal-tension-and-high-tension-glaucoma-by-spectral-domain-optical-coherence-tomography
#18
Florian S M Edlinger, Laura M Schrems-Hoesl, Christian Y Mardin, Robert Laemmer, Friedrich E Kruse, Wolfgang A Schrems
PURPOSE: Assessment of the diagnostic ability of segmented macular inner retinal layer thickness and peripapillary retinal nerve fiber layer (pRNFL) measured by spectral-domain optical coherence tomography (SD-OCT) in patients with normal-tension (NT) and high-tension (HT) perimetric and preperimetric glaucoma. METHODS: The 212 participants included 45 healthy subjects, 55 patients with ocular hypertension, 56 patients with preperimetric glaucoma, and 56 patients with perimetric glaucoma...
March 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29497582/new-normative-database-of-inner-macular-layer-thickness-measured-by-spectralis-oct-used-as-reference-standard-for-glaucoma-detection
#19
María Nieves-Moreno, José M Martínez-de-la-Casa, María P Bambo, Laura Morales-Fernández, Karel Van Keer, Evelien Vandewalle, Ingeborg Stalmans, Julián García-Feijoó
Purpose: This study examines the capacity to detect glaucoma of inner macular layer thickness measured by spectral-domain optical coherence tomography (SD-OCT) using a new normative database as the reference standard. Methods: Participants ( N = 148) were recruited from Leuven (Belgium) and Zaragoza (Spain): 74 patients with early/moderate glaucoma and 74 age-matched healthy controls. One eye was randomly selected for a macular scan using the Spectralis SD-OCT. The variables measured with the instrument's segmentation software were: macular nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) volume and thickness along with circumpapillary RNFL thickness (cpRNFL)...
February 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29497581/detecting-glaucomatous-progression-with-a-region-of-interest-approach-on-optical-coherence-tomography-a-signal-to-noise-evaluation
#20
Zhichao Wu, Abinaya Thenappan, Denis S D Weng, Robert Ritch, Donald C Hood
Purpose: To compare two region-of-interest (ROI) approaches and a global thickness approach for capturing progressive circumpapillary retinal nerve fiber layer (cpRNFL) changes on optical coherence tomography (OCT) imaging. Methods: Progressive cpRNFL thickness changes were evaluated in 164 eyes with a clinical diagnosis of glaucoma or suspected glaucoma; all eyes underwent optic disc OCT imaging on two visits at least 1 year apart. Such changes were evaluated with a manual ROI approach (ROIM ), which involved manual identification of region(s) of observed or suspected glaucomatous damage...
February 2018: Translational Vision Science & Technology
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