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OCT for glaucoma optic nerve

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https://www.readbyqxmd.com/read/29235544/relationship-of-corneal-hysteresis-and-optic-nerve-parameters-in-healthy-myopic-subjects
#1
Kunliang Qiu, Xuehui Lu, Riping Zhang, Geng Wang, Mingzhi Zhang
The association between corneal biomechanical properties and glaucoma is an area of much interest. We determined the relationship between corneal hysteresis (CH) and optic nerve parameters in healthy myopic subjects in the current study. CH was measured with Reichert Ocular Response Analyzer in 108 eyes from 108 healthy myopic subjects. All subjects received retinal nerve fiber layer and optic disc imaging Cirrus HD-OCT, GDx ECC, and Heidelberg Retina Tomograph II. None of the tested optic nerve parameters showed statistical significance with CH by using correlation analysis...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214788/asymmetry-of-peak-thicknesses-between-the-superior-and-inferior-retinal-nerve-fiber-layers-for-early-glaucoma-detection-a-simple-screening-method
#2
Hyoung Won Bae, Sang Yeop Lee, Sangah Kim, Chan Keum Park, Kwanghyun Lee, Chan Yun Kim, Gong Je Seong
PURPOSE: To assess whether the asymmetry in the peripapillary retinal nerve fiber layer (pRNFL) thickness between superior and inferior hemispheres on optical coherence tomography (OCT) is useful for early detection of glaucoma. MATERIALS AND METHODS: The patient population consisted of Training set (a total of 60 subjects with early glaucoma and 59 normal subjects) and Validation set (30 subjects with early glaucoma and 30 normal subjects). Two kinds of ratios were employed to measure the asymmetry between the superior and inferior pRNFL thickness using OCT...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29197157/application-of-the-isnt-rules-on-retinal-nerve-fibre-layer-thickness-and-neuroretinal-rim-area-in-healthy-myopic-eyes
#3
Kunliang Qiu, Geng Wang, Xuehui Lu, Riping Zhang, Lixia Sun, Mingzhi Zhang
PURPOSE: We determined the applicability of inferior > superior > nasal > temporal (ISNT) rules on retinal nerve fibre layer (RNFL) thickness and rim area and evaluated the impact of various ocular factors on the performance of the ISNT rules in healthy myopic eyes. METHODS: A total of 138 eyes from 138 healthy myopic subjects were included in this cross-sectional observational study. The peripapillary RNFL and optic disc in each eye were imaged with Cirrus HD optical coherence tomography (OCT) and Heidelberg Retina Tomograph II (HRT2), respectively...
December 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29194206/predictive-factors-for-visual-field-conversion-comparison-of-scanning-laser-polarimetry-and-optical-coherence-tomography
#4
Theresa Diekmann, Laura M Schrems-Hoesl, Christian Y Mardin, Robert Laemmer, Folkert K Horn, Friedrich E Kruse, Wolfgang A Schrems
PURPOSE: The purpose of this study was to compare the ability of scanning laser polarimetry (SLP) and spectral-domain optical coherence tomography (SD-OCT) to predict future visual field conversion of subjects with ocular hypertension and early glaucoma. METHODS: All patients were recruited from the Erlangen glaucoma registry and examined using standard automated perimetry, 24-hour intraocular pressure profile, and optic disc photography. Peripapillary retinal nerve fiber layer thickness (RNFL) measurements were obtained by SLP (GDx-VCC) and SD-OCT (Spectralis OCT)...
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29194196/use-of-optical-coherence-tomography-by-nonexpert-personnel-as-a-screening-approach-for-glaucoma
#5
Melissa M Liu, Chris Cho, Joan L Jefferys, Harry A Quigley, Adrienne W Scott
PURPOSE: This pilot study was conducted to assess optical coherence tomography (OCT) as a screening tool for glaucoma when used by nonexpert personnel. METHODS: This prospective case-control study included 54 patients with open-angle glaucoma and 54 age-matched comparison individuals. Optovue iVue SD-OCT imaging was performed by nonprofessional photographers on undilated patients. The sensitivity, specificity, negative predictive value, and positive predictive value of iVue scan parameters for detecting open-angle glaucoma were evaluated...
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29177702/-bruch-s-membrane-opening-minimum-rim-width-correlation-and-diagnostic-accuracy-in-comparison-to-peripapillary-retinal-nerve-fiber-layer-thickness
#6
M Awe, S Khalili-Amiri, I R Volkmann, B Junker, C Framme, K Hufendiek
BACKGROUND: Glaucoma is one of the main causes of blindness in the Western hemisphere. Because the disease often painlessly progresses it remains unnoticed until major optic nerve head damage occurs in many cases. That is why new, more sensitive diagnostic methods are needed. Bruch's membrane opening minimum rim width (BMO-MRW), measured with the new glaucoma module premium edition (GMPE) was recently introduced as a more accurate tool to detect glaucomatous changes. The purpose of this study was to assess the correlation of SPECTRALIS® spectral domain optical coherence tomography (SD-OCT) and the GMPE anatomic positioning module (APS module) for retinal nerve fiber layer thickness (RNFLT) measurements...
November 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29171726/factors-associated-with-deep-circulation-in-the-peripapillary-chorioretinal-atrophy-zone-in-normal-tension-glaucoma-with-myopic-disc
#7
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software...
November 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29168194/retinal-putative-glial-alterations-implication-for-glaucoma-care
#8
Bright S Ashimatey, Brett J King, William H Swanson
PURPOSE: Gliosis-like retinal alterations, presumed to be activated retinal astrocytes and Müller cells (ARAM), have been reported to occur frequently in patients with glaucoma but rarely in controls. We investigated the association between glaucomatous abnormality and the presence, the extent of retinal region, and the spatial distribution, of hyperreflective retinal alterations on optical coherence tomography (OCT) en-face images, presumed to be ARAM. METHODS: Findings of hyperreflective structures, presumed to be ARAM, in the central retinal ±24 degrees of OCT en-face images (acquired with the SPECTRALIS(®) OCT) were compared between 35 younger controls, 42 older controls and 38 patients with glaucoma...
November 23, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29157363/detecting-structural-progression-in-glaucoma-with-optical-coherence-tomography
#9
REVIEW
Andrew J Tatham, Felipe A Medeiros
Optical coherence tomography (OCT) is increasingly used to obtain objective measurements of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression. Although OCT has been adopted widely in clinical practice, uncertainty remains concerning its optimal role. Questions include: What is the best structure to measure? What quantity of change is significant? Are structural changes relevant to the patient? How are longitudinal measurements affected by aging? How can changes resulting from aging be differentiated from true progression? How best should OCT be used alongside visual fields, and how often should OCT be performed? Recent studies have addressed some of these questions...
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29140817/new-developments-in-optical-coherence-tomography-imaging-for-glaucoma
#10
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. RECENT FINDINGS: Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29133640/evaluation-of-spectral-domain-optical-coherence-tomography-parameters-in-ocular-hypertension-preperimetric-and-early-glaucoma
#11
Tuğba Aydogan, BetÜl İlkay Sezgin Akçay, Esra Kardeş, Ahmet Ergin
PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29120259/signal-alteration-in-the-optic-nerve-head-on-3d-t2-weighted-mri-a-potential-neuroimaging-sign-of-glaucomatous-optic-neuropathy
#12
Jong Yeon Lee, Hyo Jeong Kwon, Su Jin Park, Chungkwon Yoo, Yong Yeon Kim, Eung Yeop Kim
PURPOSE: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29119022/bruch-s-membrane-opening-minimum-rim-width-measurement-with-sd-oct-a-method-to-correct-for-the-opening-size-of-bruch-s-membrane
#13
Robert Kromer, Martin Stephan Spitzer
A precise evaluation of the retinal nerve fiber layer thickness (RNFLT) is key for diagnosing and monitoring glaucoma. The Bruch's membrane opening minimum rim width (BMO-MRW) has been proposed as a reproducible assessment of the optic nerve. The BMO-MRW measures the minimum distance from the BMO to the internal limiting membrane. We propose an approach to correct the BMO-MRW using the BMO size for increased accuracy in interindividual comparisons in future studies. Eighty-one healthy patients received SPECTRALIS spectral domain optical coherence tomography measurements for the peripapillary RNFLT and BMO-MRW...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29118497/comparing-ganglion-cell-inner-plexiform-layer-thickness-with-focal-and-global-responses-on-multifocal-electroretinogram-in-glaucoma
#14
Aparna Rao, Rohit V Chandrashekhar, Debananda Padhy, Sujoy Mukherjee, Gopinath Das, Sarada Sarangi
BACKGROUND: The aim of this study was to evaluate responses on multifocal electroretinogram (mfERG) with ganglion cell-inner plexiform layer (GCIPL) thickness on cirrus spectral-domain optical coherence tomography (SD-OCT) in glaucoma. METHODS: All diagnosed glaucoma patients attending glaucoma services at our institute from November 2012 to April 2013 were screened for this observational hospital-based study. Controls included patients attending our outpatient services for general eye checkup...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29114838/optical-coherence-tomography-angiography-macular-and-peripapillary-vessel-perfusion-density-in-healthy-subjects-glaucoma-suspects-and-glaucoma-patients
#15
COMPARATIVE STUDY
Giacinto Triolo, Alessandro Rabiolo, Nathan D Shemonski, Ali Fard, Federico Di Matteo, Riccardo Sacconi, Paolo Bettin, Stephanie Magazzeni, Giuseppe Querques, Luis E Vazquez, Piero Barboni, Francesco Bandello
Purpose: To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cell-inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. Methods: A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29077716/evaluation-of-retinal-nerve-fiber-layer-defect-using-wide-field-en-face-swept-source-oct-images-by-applying-the-inner-limiting-membrane-flattening
#16
Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa
PURPOSE: The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. METHODS: This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity < 0.5, axial length > 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field...
2017: PloS One
https://www.readbyqxmd.com/read/29066838/optimization-strategies-for-bruch-s-membrane-opening-minimum-rim-area-calculation-sequential-versus-simultaneous-minimization
#17
Philip Enders, Werner Adler, Friederike Schaub, Manuel M Hermann, Michael Diestelhorst, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
To compare a simultaneously optimized continuous minimum rim surface parameter between Bruch's membrane opening (BMO) and the internal limiting membrane to the standard sequential minimization used for calculating the BMO minimum rim area in spectral domain optical coherence tomography (SD-OCT). In this case-control, cross-sectional study, 704 eyes of 445 participants underwent SD-OCT of the optic nerve head (ONH), visual field testing, and clinical examination. Globally and clock-hour sector-wise optimized BMO-based minimum rim area was calculated independently...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29065606/longitudinal-changes-in-retinal-nerve-fiber-layer-thickness-evaluated-using-avanti-rtvue-xr-optical-coherence-tomography-after-23g-vitrectomy-for-epiretinal-membrane-in-patients-with-open-angle-glaucoma
#18
Anita Lyssek-Boroń, Adam Wylęgała, Katarzyna Polanowska, Katarzyna Krysik, Dariusz Dobrowolski
OBJECTIVES: The aim of this study is to evaluate longitudinal RNFL thickness changes in patients with open-angle glaucoma (OAG) who underwent pars plana vitrectomy (PPV) with epiretinal membrane (ERM) and ILM removal using OCT RTVue XR 100 Avanti. METHODS: Retrospective analysis of OCT scans of 40 patients who underwent PPV or combined phacovitrectomy with ILM peeling for the idiopathic ERM has been carried out. The patients were divided into two groups for the study: patients with the ERM and OAG and those with ERM without glaucoma...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29062772/structure-function-relationship-comparison-between-retinal-nerve-fibre-layer-and-bruch-s-membrane-opening-minimum-rim-width-in-glaucoma
#19
Lukas Reznicek, Sophie Burzer, Andrea Laubichler, Ali Nasseri, Chris P Lohmann, Nikolaus Feucht, Michael Ulbig, Mathias Maier
AIM: To evaluate and compare structural optical coherence tomography (OCT)-based parameters, such as Bruch's membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations. METHODS: Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050193/-the-vessel-and-primary-glaucoma
#20
R S Li, Y Z Pan
Glaucoma, as the first leading cause of irreversible blindness in the world, is a chronic progressive optic neuropathy. The pathogenesis of glaucoma is still not fully understood till now. A lot of studies about vascular diameter, tortuosity, location, disc perfusion, vascular regulation and systemic vascular factors had been conducted to investigate the relationship between the vascular states and glaucoma since vascular hypothesis proposed. However, direct and convincing evidence for primary mechanisms of glaucoma is still lacking...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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