Read by QxMD icon Read

OCT for glaucoma optic nerve

Edem Tsikata, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian J Que, Rong Guo, Ziad Khoueir, Johannes de Boer, Teresa C Chen
Purpose: To describe spectral-domain optical coherence tomography (OCT) methods for quantifying neuroretinal rim tissue in glaucoma and to compare these methods to the traditional retinal nerve fiber layer thickness diagnostic parameter. Methods: Neuroretinal rim parameters derived from three-dimensional (3D) volume scans were compared with the two-dimensional (2D) Spectralis retinal nerve fiber layer (RNFL) thickness scans for diagnostic capability. This study analyzed one eye per patient of 104 glaucoma patients and 58 healthy subjects...
October 1, 2016: Investigative Ophthalmology & Visual Science
Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
Sang-Yoon Lee, Eun Kyoung Lee, Ki Ho Park, Dong Myung Kim, Jin Wook Jeoung
PURPOSE: To report an asymmetry analysis of macular inner retinal layers using swept-source optical coherence tomography (OCT) and to evaluate the utility for glaucoma diagnosis. DESIGN: Observational, cross-sectional study. PARTICIPANTS: Seventy normal healthy subjects and 62 glaucoma patients. METHODS: Three-dimensional scans were acquired from 70 normal subjects and 62 open angle glaucoma patients by swept-source OCT...
2016: PloS One
Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
October 14, 2016: Journal of Glaucoma
Nicole K Scripsema, Patricia M Garcia, Richard D Bavier, Toco Y P Chui, Brian D Krawitz, Shelley Mo, Steven A Agemy, Luna Xu, Yijie B Lin, Joseph F Panarelli, Paul A Sidoti, James C Tsai, Richard B Rosen
Purpose: To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). Methods: A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3...
July 1, 2016: Investigative Ophthalmology & Visual Science
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Siamak Yousefi, Luke J Saunders, Akram Belghith, Patricia Isabel C Manalastas, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 153 eyes from 31 healthy participants, 48 glaucoma suspects, and 74 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: All eyes underwent imaging using OCT-A (Angiovue; Optovue, Fremont, CA), spectral-domain OCT (Avanti; Optovue), and standard automated perimetry (SAP)...
October 7, 2016: Ophthalmology
Abdel-Razzak M Al-Hinnawi, Bassam O Al-Naami, Motasem M Al-Latayfeh
PURPOSE: To investigate monitoring slope-based features of the optic nerve head (ONH) cup as open-angle glaucoma (OAG) occurs. METHOD: A dataset of 46 retrospective OCT cases was acquired from the SPECTRALIS Heidelberg Engineering OCT device. A set of five parameters, which are based on the ONH cup-incline, are measured on the OAG and normal subjects in the dataset. Then, three new ONH cup-shape indices were deduced. The ONH cup-incline parameters and ONH cup-shape indices are analyzed to estimate their clinical value...
September 28, 2016: International Ophthalmology
J D Unterlauft, H Tegetmeyer
Background: With a cooperative patient, examination of the optic nerve head using optical coherence tomography (OCT) is fast and easy to perform and facilitates identification and monitoring of different pathological changes in the optic nerve head. Materials and Methods: Characteristic findings and scanning options are illustrated using case examples to simplify recognition of infrequent diseases of the optic nerve head and to facilitate treatment decisions using OCT results. Results: Pathological changes and characteristic OCT findings are shown for glaucoma, for different anomalies of the optic nerve head, for non-glaucomatous optic atrophies and for optic disc swelling for different reasons...
September 27, 2016: Klinische Monatsblätter Für Augenheilkunde
J Ahn, I S Yun, H G Yoo, J-J Choi, M Lee
PurposeTo evaluate a progression-detecting algorithm for a new automated matched alternation flicker (AMAF) in glaucoma patients.MethodsOpen-angle glaucoma patients with a baseline mean deviation of visual field (VF) test>-6 dB were included in this longitudinal and retrospective study. Functional progression was detected by two VF progression criteria and structural progression by both AMAF and conventional comparison methods using optic disc and retinal nerve fiber layer (RNFL) photography. Progression-detecting performances of AMAF and the conventional method were evaluated by an agreement between functional and structural progression criteria...
September 23, 2016: Eye
Xinbo Zhang, Anna Dastiridou, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, Mitra Sehi, Vikas Chopra, David Huang
PURPOSE: To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open angle glaucoma. DESIGN: Multicenter cohort study. METHODS: Participants from Advanced Imaging for Glaucoma (AIG) study were enrolled and followed-up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (p<0.05) negative slope for VF index (VFI). Fourier-domain optical coherence tomography (FD-OCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness parameters...
September 17, 2016: American Journal of Ophthalmology
Anani P Toshev, Julia Lamparter, Norbert Pfeiffer, Esther M Hoffmann
PURPOSE: To compare the diagnostic performance and evaluate diagnostic agreement for early glaucoma detection between a confocal scanning laser ophthalmoscope (CSLO) and a spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: Fifty-five eyes of 55 open-angle glaucoma patients and 42 eyes of 42 healthy control subjects were enrolled in this observational, cross-sectional study. All participants underwent comprehensive ophthalmic examination, visual field testing, and optic nerve head and retinal nerve fiber layer imaging by CSLO (HRT3) and SD-OCT (Spectralis OCT)...
September 15, 2016: Journal of Glaucoma
Arezoo Miraftabi, Navid Amini, Esteban Morales, Sharon Henry, Fei Yu, Abdolmonem Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
PURPOSE: We tested the hypothesis that the macular ganglion cell layer (GCL) thickness demonstrates a stronger structure-function (SF) relationship and extends the useful range of macular measurements compared with combined macular inner layer or full thickness. METHODS: Ninety-eight glaucomatous eyes and eight normal eyes with macular spectral domain optical coherence tomography (SD-OCT) volume scans and 10-2 visual fields were enrolled. Inner plexiform layer (IPL), GCL, macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), and full thickness (FT) measurements were calculated for 8 × 8 arrays of 3° superpixels...
September 1, 2016: Investigative Ophthalmology & Visual Science
Mehmet Giray Ersoz, Duygu Kunak Mart, Emre Ayintap, Leyla Hazar, Irfan Botan Gunes, Seda Karaca Adiyeke, Beysim Dogan
PURPOSE: To investigate whether there is a difference between primary open-angle glaucoma (POAG) patients and control group with regard to choroidal thickness (CT) and the factors influencing CT. METHODS: Ninety eyes of 90 patients who were being followed up with POAG and 72 eyes of 72 healthy subjects matched for age and gender were included. Peripapillary retinal nerve fiber layer thickness (RNFLT), peripapillary CT, lamina cribrosa thickness (LCT), and prelaminar tissue thickness (PTT) were measured with spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI) in all patients...
September 12, 2016: International Ophthalmology
Masoud Aghsaei Fard, Marjan Afzali, Parisa Abdi, Rebecca Chen, Mehdi Yaseri, Ebrahim Azaripour, Sasan Moghimi
PURPOSE: To compare optic nerve head (ONH) morphology of optic nerve atrophy between eyes with primary open-angle glaucoma (POAG) and eyes with a history of nonarteritic anterior ischemic optic atrophy (NAION) using enhanced depth imaging (EDI) with spectral-domain optical coherence tomography (SD-OCT). METHODS: In this cross-sectional study, 121 eyes of 91 patients consisted of moderate to severe POAG (n = 32 eyes), visual field mean deviation-matched NAION (n = 30 eyes) and their fellow eyes (n = 30 eyes), and healthy controls (n = 29)...
September 1, 2016: Investigative Ophthalmology & Visual Science
Neda Baniasadi, Eleftherios I Paschalis, Mahdi Haghzadeh, Pallavi Ojha, Tobias Elze, Mufeed Mahd, Teresa C Chen
PURPOSE OF THE STUDY: The purpose of the study was to determine whether there are different patterns of retinal nerve fiber layer (RNFL) thinning as measured by spectral domain optical coherence tomography (SD-OCT) for 4 subtypes of open angle glaucoma (OAG): primary OAG (POAG), normal tension glaucoma (NTG), pseudoexfoliation glaucoma (PXG), and pigmentary glaucoma (PDG) and to compare them with normal controls. MATERIALS AND METHODS: SD-OCT RNFL thickness values were measured for 4 quadrants and for 4 sectors (ie, superior-nasal, superior-temporal, inferior-nasal, and inferior-temporal)...
October 2016: Journal of Glaucoma
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Siamak Yousefi, Robert N Weinreb
PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage...
August 31, 2016: Ophthalmology
Lilian Hui Li Koh, Muhammad Amir Ismail, Sae Cheong Yap, Elizabeth Poh Ying Wong, Leonard Wei Leon Yip
AIM: To assess the repeatability of measuring optic nerve head (ONH) parameters using the Cirrus optical coherence tomography (OCT), as well as to assess the effect of head tilt on these measurements. METHODS: Thirty healthy participants with no evidence of glaucoma were recruited for the study. Visual acuity, intraocular pressure, standard automated perimetry and ocular examination were performed for each participant. One eye was then randomly selected and scanned undilated with the Cirrus OCT in 3 positions (neutral, 30° right tilt and 30° left tilt)...
2016: International Journal of Ophthalmology
Gábor Holló
BACKGROUND/PURPOSE: Optical coherence tomography (OCT) angiography is a new noninvasive method to measure peripapillary microcirculation in various retinal layers, separately. In this case series, we investigate whether large medical intraocular pressure (IOP) reduction (>50% of the untreated baseline value) to IOP≤18 mm Hg influences peripapillary angioflow density (PAFD, percentage of the analyzed retinal area) in the retinal nerve fiber layer in high pressure (IOP≥35 mm Hg) ocular hypertensive and glaucoma eyes...
August 26, 2016: Journal of Glaucoma
Florian Rüfer, Julia Jasmin Bartsch, Carl Erb, Anneliese Riehl, Philipp Franko Zeitz
PURPOSE: We aimed to examine the extent to which measurement errors in the determination of retinal nerve fibre layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) occur in cases of epiretinal membrane and whether systematic deviations are found in the values obtained. METHODS: A macular scan and a circumpapillary scan were performed on 97 eyes of 97 patients using SD-OCT. Group 1 comprised 53 patients with epiretinal membrane at an age of 70 ± 4...
October 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Naoko Takada, Kazuko Omodaka, Tsutomu Kikawa, Airi Takagi, Akiko Matsumoto, Yu Yokoyama, Yukihiro Shiga, Kazuichi Maruyama, Hidetoshi Takahashi, Masahiro Akiba, Toru Nakazawa
PURPOSE: To objectively classify the optic discs of open-angle glaucoma (OAG) patients into Nicolela's four disc types, i.e., focal ischemic (FI), myopic (MY), senile sclerotic (SS), and generalized enlargement (GE), with swept-source optical coherence tomography (SS-OCT). METHODS: This study enrolled 113 eyes of 113 OAG patients (mean age: 62.5 ± 12.6; Humphrey field analyzer-measured mean deviation: -9.4 ± 7.3 dB). Newly developed software was used to quantify a total of 20 optic disc parameters in SS-OCT (DRI OCT-1, TOPCON) images of the optic disc...
2016: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"