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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#1
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29329139/diagnostic-ability-and-structure-function-relationship-of-peripapillary-optical-microangiography-measurements-in-glaucoma
#2
Harsha L Rao, Srilakshmi Dasari, Mohammed Riyazuddin, Narendra K Puttaiah, Zia S Pradhan, Robert N Weinreb, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To evaluate the diagnostic abilities of peripapillary optical microangiography (OMAG) measurements in eyes with primary open angle glaucoma (POAG) and to evaluate the relationship of these measurements with retinal nerve fiber layer (RNFL) thickness and visual sensitivities in different peripapillary sectors. METHODS: In a cross-sectional study, 97 eyes of 57 control subjects and 101 eyes of 66 POAG patients underwent OMAG and RNFL imaging with optical coherence tomography...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29320503/pattern-of-peripapillary-capillary-density-loss-in-ischemic-optic-neuropathy-compared-to-that-in-primary-open-angle-glaucoma
#3
Masoud Aghsaei Fard, Yanin Suwan, Sasan Moghimi, Lawrence S Geyman, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness. METHODS: 31 chronic NAION (>6 months after the acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged with a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions...
2018: PloS One
https://www.readbyqxmd.com/read/29318383/optical-coherence-tomography-angiography-a-review-of-current-and-future-clinical-applications
#4
REVIEW
Marcus Ang, Anna C S Tan, Chui Ming Gemmy Cheung, Pearse A Keane, Rosa Dolz-Marco, Chelvin C A Sng, Leopold Schmetterer
Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age related macular degeneration and retinal vascular diseases...
January 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29313052/a-deep-learning-approach-to-digitally-stain-optical-coherence-tomography-images-of-the-optic-nerve-head
#5
Sripad Krishna Devalla, Khai Sing Chin, Jean-Martial Mari, Tin A Tun, Nicholas G Strouthidis, Tin Aung, Alexandre H Thiéry, Michaël J A Girard
Purpose: To develop a deep learning approach to digitally stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for one eye of each of 100 subjects (40 healthy and 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally stain (i.e., highlight) six tissue layers of the ONH...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29303879/comparison-of-peripapillary-oct-angiography-vessel-density-and-retinal-nerve-fiber-layer-thickness-measurements-for-their-ability-to-detect-progression-in-glaucoma
#6
Gábor Holló
PURPOSE: To investigate the applicability of peripapillary optical coherence tomography angiography angioflow vessel-density measurements in the retinal nerve fiber layer for the detection of glaucomatous progression; and to compare its performance with that of retinal nerve fiber layer thickness (RNFLT) measurements. METHODS: Prospective RNFLT and vessel-density measurements with the same Angiovue/RTVue-XR instrument were made immediately after each other on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits for all eyes)...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303874/localized-retinal-nerve-fiber-layer-defects-in-red-free-photographs-versus-en-face-structural-optical-coherence-tomography-images
#7
Jae Hoon Jung, Ji-Hye Park, Chungkwon Yoo, Yong Yeon Kim
PURPOSE: To compare the locations of localized retinal nerve fiber layer (RNFL) defects in red-free fundus photographs and optical coherence tomography (OCT) en face images. METHODS: We performed a retrospective, comparative study on 46 eyes from 46 glaucoma patients with localized RNFL defects observed in red-free fundus photographs. En face structural images were obtained in the superficial and whole retinal layers using OCT and were overlaid on the corresponding red-free fundus photographs...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303870/the-association-between-macula-and-onh-optical-coherence-tomography-angiography-oct-a-vessel-densities-in-glaucoma-glaucoma-suspect-and-healthy-eyes
#8
Patricia Isabel C Manalastas, Linda M Zangwill, Fabio B Daga, Mark A Christopher, Luke J Saunders, Takuhei Shoji, Tadamichi Akagi, Rafaella C Penteado, Adeleh Yarmohammadi, Min Hee Suh, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate strength of associations between Optical Coherence Tomography-Angiography (OCT-A) vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. METHODS: This cross-sectional study included 333 eyes of 219 primary open angle glaucoma patients, 41 glaucoma suspects, and 73 healthy participants from the Diagnostics Innovations in Glaucoma Study (DIGS) with good quality OCT-A images...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29296488/multi-directional-optical-coherence-tomography-for-retinal-imaging
#9
Andreas Wartak, Marco Augustin, Richard Haindl, Florian Beer, Matthias Salas, Marie Laslandes, Bernhard Baumann, Michael Pircher, Christoph K Hitzenberger
We introduce multi-directional optical coherence tomography (OCT), a technique for investigation of the scattering properties of directionally reflective tissue samples. By combining the concepts of multi-channel and directional OCT, this approach enables simultaneous acquisition of multiple reflectivity depth-scans probing a mutual sample location from differing angular orientations. The application of multi-directional OCT in retinal imaging allows for in-depth investigations on the directional reflectivity of the retinal nerve fiber layer, Henle's fiber layer and the photoreceptor layer...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29283693/anterograde-transport-in-axons-of-the-retinal-ganglion-cells-and-its-relationship-to-the-intraocular-pressure-during-aging-in-mice-with-hereditary-pigmentary-glaucoma
#10
Michal Fiedorowicz, Jaroslaw Orzel, Bartosz Kossowski, Marlena Welniak-Kaminska, Tomasz Choragiewicz, Maciej Swiatkiewicz, Robert Rejdak, Piotr Bogorodzki, Pawel Grieb
PURPOSE: To establish a relationship between impairment of the anterograde axonal transport (AAT) in the axons of the retinal ganglion cells and the intraocular pressure (IOP) during aging in mice with hereditary glaucoma. METHODS: Quantitative in vivo approach based on manganese enhanced magnetic resonance imaging was developed in order to evaluate AAT in 3-, 6-, and 14-month old DBA/2J mice that develop age-dependent pigmentary glaucoma or age-matched C57Bl/6 mice that do not develop any retinal disease...
December 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29235544/relationship-of-corneal-hysteresis-and-optic-nerve-parameters-in-healthy-myopic-subjects
#11
Kunliang Qiu, Xuehui Lu, Riping Zhang, Geng Wang, Mingzhi Zhang
The association between corneal biomechanical properties and glaucoma is an area of much interest. We determined the relationship between corneal hysteresis (CH) and optic nerve parameters in healthy myopic subjects in the current study. CH was measured with Reichert Ocular Response Analyzer in 108 eyes from 108 healthy myopic subjects. All subjects received retinal nerve fiber layer and optic disc imaging Cirrus HD-OCT, GDx ECC, and Heidelberg Retina Tomograph II. None of the tested optic nerve parameters showed statistical significance with CH by using correlation analysis...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214709/imaging-of-the-lamina-cribrosa-and-its-role-in-glaucoma-a-review
#12
REVIEW
Nicholas Yq Tan, Victor Koh, Michaël Ja Girard, Ching-Yu Cheng
The lamina cribrosa of the optic nerve head serves two contrasting roles; it must be porous to allow retinal ganglion cell axons to pass through, and yet at the same time, it must also provide adequate structural support to withstand the stresses and strains across it. Improvements in imaging such as optical coherence tomography image capture and image processing have allowed detailed in vivo studies of lamina cribrosa macro- and micro-architectural characteristics. This has aided our understanding of the optic nerve head as a complex biomechanical structure...
December 7, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29197157/application-of-the-isnt-rules-on-retinal-nerve-fibre-layer-thickness-and-neuroretinal-rim-area-in-healthy-myopic-eyes
#13
Kunliang Qiu, Geng Wang, Xuehui Lu, Riping Zhang, Lixia Sun, Mingzhi Zhang
PURPOSE: We determined the applicability of inferior > superior > nasal > temporal (ISNT) rules on retinal nerve fibre layer (RNFL) thickness and rim area and evaluated the impact of various ocular factors on the performance of the ISNT rules in healthy myopic eyes. METHODS: A total of 138 eyes from 138 healthy myopic subjects were included in this cross-sectional observational study. The peripapillary RNFL and optic disc in each eye were imaged with Cirrus HD optical coherence tomography (OCT) and Heidelberg Retina Tomograph II (HRT2), respectively...
December 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29194196/use-of-optical-coherence-tomography-by-nonexpert-personnel-as-a-screening-approach-for-glaucoma
#14
Melissa M Liu, Chris Cho, Joan L Jefferys, Harry A Quigley, Adrienne W Scott
PURPOSE: This pilot study was conducted to assess optical coherence tomography (OCT) as a screening tool for glaucoma when used by nonexpert personnel. METHODS: This prospective case-control study included 54 patients with open-angle glaucoma and 54 age-matched comparison individuals. Optovue iVue SD-OCT imaging was performed by nonprofessional photographers on undilated patients. The sensitivity, specificity, negative predictive value, and positive predictive value of iVue scan parameters for detecting open-angle glaucoma were evaluated...
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29190029/3d-histomorphometric-reconstruction-and-quantification-of-the-optic-nerve-head-connective-tissues
#15
Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Stuart K Gardiner, Claude F Burgoyne
Accurately characterizing the 3D geometry of the optic nerve head neural and connective tissues has been the goal of a large and important body of scientific work. In the present report, we summarize our methods for the high-resolution, digital, 3D histomorphometric reconstruction of the optic nerve head tissues, including their visualization, parameterization, and quantification. In addition, we present our methods for between-eye comparisons of this anatomy, and their use to determine animal-specific and experiment-wide experimental glaucoma versus Control eye differences in the unilateral, monkey experimental glaucoma model...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29180847/optic-disc-segmentation-for-glaucoma-screening-system-using-fundus-images
#16
Ahmed Almazroa, Weiwei Sun, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
Segmenting the optic disc (OD) is an important and essential step in creating a frame of reference for diagnosing optic nerve head pathologies such as glaucoma. Therefore, a reliable OD segmentation technique is necessary for automatic screening of optic nerve head abnormalities. The main contribution of this paper is in presenting a novel OD segmentation algorithm based on applying a level set method on a localized OD image. To prevent the blood vessels from interfering with the level set process, an inpainting technique was applied...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29178525/flow-dynamics-of-cerebrospinal-fluid-between-the-intracranial-cavity-and-the-subarachnoid-space-of-the-optic-nerve-measured-with-a-diffusion-magnetic-resonance-imaging-sequence-in-patients-with-normal-tension-glaucoma
#17
Dirk Boy, Margherita Montali, Neil R Miller, Achmed Pircher, Philipp Gruber, Hans-Peter E Killer, Luca Remonda, Jatta Berberat
IMPORTANCE: This study offers a new approach for the quantification of CSF-dynamics. BACKGROUND: Non-invasive method to quantify the CSF-dynamics in the subarachnoid-space of the optic nerve is highly desirable. The aim of the study was to measure slow-flow CSF-velocities in healthy controls and normal-tension glaucoma patients between the intracranial cavity and the subarachnoid-space of the optic nerve. DESIGN: Prospective observational study...
November 25, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29171726/factors-associated-with-deep-circulation-in-the-peripapillary-chorioretinal-atrophy-zone-in-normal-tension-glaucoma-with-myopic-disc
#18
Naoki Kiyota, Hiroshi Kunikata, Seri Takahashi, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To investigate factors associated with choroidal microcirculation in the peripapillary chorioretinal atrophy (PPA) zone in eyes with normal-tension glaucoma (NTG) and myopic disc. METHODS: In 100 eyes of 100 NTG patients with myopic disc and 20 eyes of 20 age-matched myopic controls, 4.5 × 4.5 mm scans were made of the optic nerve head with optical coherence tomography angiography (OCTA). Peripapillary chorioretinal atrophy (PPA) area and PPA superficial choroidal image intensity (PPA-CI) were calculated with image j software...
November 24, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29168194/retinal-putative-glial-alterations-implication-for-glaucoma-care
#19
Bright S Ashimatey, Brett J King, William H Swanson
PURPOSE: Gliosis-like retinal alterations, presumed to be activated retinal astrocytes and Müller cells (ARAM), have been reported to occur frequently in patients with glaucoma but rarely in controls. We investigated the association between glaucomatous abnormality and the presence, the extent of retinal region, and the spatial distribution, of hyperreflective retinal alterations on optical coherence tomography (OCT) en-face images, presumed to be ARAM. METHODS: Findings of hyperreflective structures, presumed to be ARAM, in the central retinal ±24 degrees of OCT en-face images (acquired with the SPECTRALIS(®) OCT) were compared between 35 younger controls, 42 older controls and 38 patients with glaucoma...
November 23, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29165935/peripapillary-perfused-capillary-density-in-exfoliation-syndrome-and-exfoliation-glaucoma-versus-poag-and-healthy-controls-an-octa-study
#20
Yanin Suwan, Lawrence S Geyman, Masoud Aghsaei Fard, Apichat Tantraworasin, Toco Y Chui, Richard B Rosen, Robert Ritch
PURPOSE: To compare the peripapillary perfused capillary density (PCD) among eyes with exfoliation syndrome (XFS), exfoliation glaucoma (XFG), primary open-angle glaucoma (POAG), and controls. DESIGN: Observational, cross-sectional study. METHODS: Optical coherence tomography angiography (OCTA) images (4.5×4.5 mm) of the optic nerve head were obtained using a commercial spectral domain OCTA system (AngioVue Avanti RTVue-XR, OptoVue, Fremont, CA)...
November 22, 2017: Asia-Pacific Journal of Ophthalmology
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