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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/28931182/-primary-open-angle-glaucoma
#1
Esther M Hoffmann, Verena Prokosch-Willing
Glaucoma leads to blindness but there are diagnostic and therapeutic developments that aid ophthalmologists in the improved mangement of the disease compared to the past. Known risk factors such as age, myopia, dark pigmented skin, genetics, and elevated intraocular pressure play an important role for the individual patient's prognosis, and many yet unknown or not sufficiently investigated risk factors come along. The structured examination of the optic nerve head is crucial for the clincial diagnosis by the ophthalmologist...
September 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28929241/assessment-of-peripapillary-choroidal-thickness-in-primary-open-angle-glaucoma-patients-with-choroidal-vascular-prominence
#2
Yong Ju Song, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the relationship between peripapillary choroidal thickness (PCT) and choroidal vascular prominence (CVP) colocalized with retinal nerve fiber layer (RNFL) defect in primary open-angle glaucoma (POAG) eyes and to evaluate the relationship between PCT and POAG severity. METHODS: In this cross-sectional comparative study, 29 POAG patients with CVP on RNFL imaging (Group A), 70 POAG patients without CVP (Group B) and 63 healthy controls (Group C) were examined...
September 19, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#3
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28919543/correlation-of-echographic-and-photographic-assessment-of-optic-nerve-head-cupping-in-children
#4
Mohamed S Sayed, Elizabeth A Dale, Carla J Osigian, Kara M Cavuoto, Wei Shi, Ta C Chang
PURPOSE: To determine the diagnostic value of B-scan echography in optic nerve head (ONH) cupping estimation in children. METHODS: The medical records of pediatric patients who had previously undergone examination under anesthesia and for whom both adequate B-scan echography images and optic nerve head (ONH) photographs and were available were reviewed retrospectively. The cup:disk ratio was estimated with a grading scale of 0-1.0 and rounded to the nearest tenth; degree of cupping was estimated from B-scan echography (small, medium, or large) by 5 masked graders (3 glaucoma specialists and 2 ocular sonographers) on 2 separate occasions...
September 14, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28915256/optical-coherence-tomography-angiography-of-the-peripapillary-capillaries-in-primary-open-angle-and-normal-tension-glaucoma
#5
Ryoko Igarashi, Shun Ochiai, Yuta Sakaue, Aki Suetake, Ryu Iikawa, Testuya Togano, Fuuko Miyamoto, Daiki Miyamoto, Takeo Fukuchi
OBJECTIVES: To evaluate the vascular architecture of the radial peripapillary capillaries (RPCs) and its relation with visual function in patients with open-angle glaucoma (OAG) and normal-tension glaucoma using spectral-domain optical coherence tomography (SD-OCT) angiography. SUBJECTS AND METHODS: Clear OCT angiography images of blood vessels in the optic disc and peripapillary retina were obtained from 52 patients (52 eyes) aged 55.42±10.64 (range 28-72) years with primary OAG...
2017: PloS One
https://www.readbyqxmd.com/read/28910165/peripapillary-choroidal-thickness-and-retinal-nerve-fiber-layer-in-untreated-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-a-case-control-study
#6
Serpil Yazgan, Fatma Erboy, Haci Ugur Celik, Tacettin Ornek, Suat Hayri Ugurbas, Firuzan Kokturk, Orhan Ayar, Mehmet Orcun Akdemir, Erkan Celik
PURPOSE: To evaluate peripapillary choroidal thickness (PPCT), central macular choroidal thickness (CMCT), and retinal nerve fiber layer (RNFL) thickness in untreated patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: This prospective, randomized, and comparative study was conducted in a university ophthalmology clinic. 106 eyes of 106 patients with OSAHS and 44 eyes of 44 healthy individuals were evaluated in this study. Only right eyes were evaluated...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28898516/structural-and-functional-imaging-of-aqueous-humor-outflow-a-review
#7
REVIEW
Alex S Huang, Brian A Francis, Robert N Weinreb
Maintaining healthy aqueous humor outflow (AHO) is important for intraocular cellular health and stable vision. Impairment of AHO can lead to increased intraocular pressure, optic nerve damage, and concomitant glaucoma. An improved understanding of AHO will lead to improved glaucoma surgeries that enhance native AHO as well as facilitate the development of AHO-targeted pharmaceuticals. Recent AHO imaging has evolved to live human assessment and has focused on the structural evaluation of AHO pathways and the functional documentation of fluid flow...
September 12, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28898356/structure-function-relationships-in-perimetric-glaucoma-comparison-of-minimum-rim-width-and-retinal-nerve-fiber-layer-parameters
#8
COMPARATIVE STUDY
Navid Amini, Ramin Daneshvar, Farideh Sharifipour, Pablo Romero, Sharon Henry, Joseph Caprioli, Kouros Nouri-Mahdavi
Purpose: To test the hypotheses that: (1) structure-function (SF) relationships between visual fields (VF) and Bruch's membrane opening-based minimum rim width (BMO-MRW) measurements are superior to those for peripapillary retinal nerve fiber layer (pRNFL) in perimetric glaucoma; (2) BMO-MRW measurements may extend the utility of structural measurement across the range of glaucoma severity; and (3) to estimate the influence of Bruch's membrane opening (BMO) size on BMO-MRW measurements...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28868033/sturge-weber-syndrome-associated-with-monolateral-ocular-melanocytosis-iris-mammillations-and-diffuse-choroidal-haemangioma
#9
Andrea Maria Plateroti, Rocco Plateroti, Roberto Mollo, Aloisa Librando, Maria Teresa Contestabile, Vito Fenicia
We present the case of a 12-year-old boy with Sturge-Weber syndrome and ocular melanocytosis who presented with bilateral naevus flammeus of the face and hyperpigmentation of the right iris associated with ipsilateral iris mammillations. The patient had glaucoma and a diffuse choroidal haemangioma of the right eye. Optical coherence tomography of the anterior segment confirmed iris hyper-pigmentation and did not show abnormalities of the chamber angle structures. B-scan ultrasonography and enhanced depth imaging optical coherence tomography were performed and showed a marked difference in thickness and reflectance between the right and left choroid...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28867515/morphometric-parameters-of-the-optic-disc-in-normal-and-glaucomatous-eyes-based-on-time-domain-optical-coherence-tomography-image-analysis
#10
Dovilė Buteikienė, Asta Kybartaitė-Žilienė, Loresa Kriaučiūnienė, Valerijus Barzdžiukas, Ingrida Janulevičienė, Alvydas Paunksnis
BACKGROUND AND OBJECTIVE: Assessment of optic disc morphology is essential in diagnosis and management of visual impairment. The aim of this study was to evaluate associations between optic disc morphometric parameters, i.e., size and shape, and age, gender, and ocular axial length in normal and glaucomatous eyes based on time-domain optical coherence tomography image analysis. MATERIALS AND METHODS: It was a case-control study of 998 normal and 394 eyes with primary open angle glaucoma that underwent an ophthalmological examination and time-domain optical coherence topography scanning...
July 18, 2017: Medicina
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#11
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28858153/attenuation-coefficients-from-sd-oct-data-structural-information-beyond-morphology-on-rnfl-integrity-in-glaucoma
#12
Gijs Thepass, Hans G Lemij, Koenraad A Vermeer
PURPOSE: To explore the attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL) in spectral domain optical coherence tomography (OCT) images, in healthy eyes and eyes affected by glaucoma. To assess the relation between RNLF AC, disease severity, RNFL thickness, visual field sensitivity threshold, spatial location and age. PATIENTS AND METHODS: We analyzed peripapillary circle scans of a clinical OCT device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany) in 102 glaucoma patients and 90 healthy controls...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28858152/prevalence-and-associated-factors-of-segmentation-errors-in-the-peripapillary-retinal-nerve-fiber-layer-and-macular-ganglion-cell-complex-in-spectral-domain-optical-coherence-tomography-images
#13
Astuya Miki, Miho Kumoi, Shinichi Usui, Takao Endo, Rumi Kawashima, Takeshi Morimoto, Kenji Matsushita, Takashi Fujikado, Kohji Nishida
PURPOSE: To determine the prevalence of errors in segmentation of the peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) boundary in spectral-domain optical coherence tomography (SDOCT) images, and to identify factors associated with the errors. PATIENTS AND METHODS: Peripapillary RNFL circle scans and macular three-dimensional scans of consecutive cases imaged with SDOCT (RS-3000 Advance; Nidek, Gamagori, Japan) were retrospectively reviewed by a glaucoma specialist...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28857943/visibility-of-optic-nerve-head-structures-with-spectral-domain-and-swept-source-optical-coherence-tomography
#14
Mónica M Loureiro, Jayme R Vianna, Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT). MATERIALS AND METHODS: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 lines each, centered on the ONH)...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28855629/location-of-the-central-retinal-vessel-trunk-in-the-laminar-and-prelaminar-tissue-of-healthy-and-glaucomatous-eyes
#15
Bo Wang, Katie A Lucy, Joel S Schuman, Hiroshi Ishikawa, Richard A Bilonick, Ian A Sigal, Larry Kagemann, Chen Lu, James G Fujimoto, Gadi Wollstein
Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT)...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846773/racioethnic-differences-in-human-posterior-scleral-and-optic-nerve-stump-deformation
#16
COMPARATIVE STUDY
Ehab A Tamimi, Jeffrey D Pyne, Dominic K Muli, Katelyn F Axman, Stephen J Howerton, Matthew R Davis, Christopher A Girkin, Jonathan P Vande Geest
Purpose: The purpose of this study was to quantify the biomechanical response of human posterior ocular tissues from donors of various racioethnic groups to better understand how differences in these properties may play a role in the racioethnic health disparities known to exist in glaucoma. Methods: Sequential digital image correlation (S-DIC) was used to measure the pressure-induced surface deformations of 23 normal human posterior poles from three racioethnic groups: African descent (AD), European descent (ED), and Hispanic ethnicity (HIS)...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28835424/compressed-3d-and-2d-digital-images-versus-standard-3d-slide-film-for-the-evaluation-of-glaucomatous-optic-nerve-features
#17
Simrenjeet Sandhu, Chris Rudnisky, Sourabh Arora, Faazil Kassam, Gordon Douglas, Marianne C Edwards, Karin Verstraten, Beatrice Wong, Karim F Damji
SYNOPSIS: Clinicians can feel confident compressed three-dimensional digital (3DD) and two-dimensional digital (2DD) imaging evaluating important features of glaucomatous disc damage is comparable to the previous gold standard of stereoscopic slide film photography, supporting the use of digital imaging for teleglaucoma applications. BACKGROUND/AIMS: To compare the sensitivity and specificity of 3DD and 2DD photography with stereo slide film in detecting glaucomatous optic nerve head features...
August 23, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28832670/peripapillary-retinal-splitting-visualized-on-oct-in-glaucoma-and-glaucoma-suspect-patients
#18
Dilraj S Grewal, Daniel J Merlau, Pushpanjali Giri, Marion R Munk, Amani A Fawzi, Lee M Jampol, Angelo P Tanna
PURPOSE: To identify the risk factors for development of peripapillary retinal splitting (schisis) in patients with glaucoma or suspicion of glaucoma. SETTING: Glaucoma Clinic, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL. METHODS: In this institutional cross-sectional study, 495 patients (990 eyes) who had undergone spectral-domain optical coherence tomography (OCT Spectralis HRA-OCT, Heidelberg Engineering) optic nerve head (ONH) imaging and did not have identifiable optic nerve pits, pseudopits or coloboma were included...
2017: PloS One
https://www.readbyqxmd.com/read/28829843/magnetic-resonance-imaging-of-optic-nerve-traction-during-adduction-in-primary-open-angle-glaucoma-with-normal-intraocular-pressure
#19
Joseph L Demer, Robert A Clark, Soh Youn Suh, JoAnn A Giaconi, Kouros Nouri-Mahdavi, Simon K Law, Laura Bonelli, Anne L Coleman, Joseph Caprioli
Purpose: We used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG). Methods: Seventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and 31 controls underwent MRI in central gaze and 20° to 30° abduction and adduction. Optic nerve and sheath area centroids permitted computation of midorbital lengths versus minimum paths. Results: Average mean deviation (±SEM) was -8...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28811934/the-estimates-of-retinal-ganglion-cell-counts-performed-better-than-isolated-structure-and-functional-tests-for-glaucoma-diagnosis
#20
Bruno L B Esporcatte, Andrea C Kara-José, Luiz Alberto S Melo, Luciano M Pinto, Ivan M Tavares
PURPOSE: To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). METHODS: Healthy individuals and glaucoma patients were included in this cross-sectional study. All eyes underwent 24-2 SITA SAP and structural imaging tests. RGC count estimates were obtained using a previously described algorithm, which combines estimates of RGC numbers from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer (RNFL) average thickness...
2017: Journal of Ophthalmology
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