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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/28449038/real-time-imaging-of-single-neuronal-cell-apoptosis-in-patients-with-glaucoma
#1
Maria F Cordeiro, Eduardo M Normando, M Jorge Cardoso, Serge Miodragovic, Seham Jeylani, Benjamin M Davis, Li Guo, Sebastien Ourselin, Roger A'Hern, Philip A Bloom
Retinal cell apoptosis occurs in many ocular neurodegenerative conditions including glaucoma-the major cause of irreversible blindness worldwide. Using a new imaging technique that we have called DARC (detection of apoptosing retinal cells), which until now has only been demonstrated in animal models, we assessed if annexin 5 labelled with fluorescent dye DY-776 (ANX776) could be used safely in humans to identify retinal cell apoptosis. Eight patients with glaucomatous neurodegeneration and evidence of progressive disease, and eight healthy subjects were randomly assigned to intravenous ANX776 doses of 0...
April 26, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28446148/circumpapillary-retinal-nerve-fiber-layer-thickness-anterior-lamina-cribrosa-depth-and-lamina-cribrosa-thickness-in-neovascular-glaucoma-secondary-to-proliferative-diabetic-retinopathy-a-cross-sectional-study
#2
Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani
BACKGROUND: To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography. METHODS: Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28433445/parapapillary-choroidal-microvasculature-dropout-in-glaucoma-a-comparison-between-optical-coherence-tomography-angiography-and-indocyanine-green-angiography
#3
Eun Ji Lee, Kyoung Min Lee, Seung Hyen Lee, Tae-Woo Kim
PURPOSE: To investigate whether the parapapillary choroidal microvasculature dropout (MvD) determined by optical coherence tomography angiography (OCTA) in glaucomatous eyes indicates a true perfusion defect and whether the MvD accurately represents the area of nonperfusion. DESIGN: Observational case series. PARTICIPANTS: Thirty primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by OCTA and 13 POAG patients without this dropout...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28432111/regional-vascular-density-visual-field-sensitivity-relationship-in-glaucoma-according-to-disease-severity
#4
Joong Won Shin, Jiyun Lee, Junki Kwon, Jaewan Choi, Michael S Kook
AIMS: To study whether there are global and regional relationships between peripapillary vascular density (pVD) assessed by optical coherence tomography angiography (OCT-A) and visual field (VF) mean sensitivity at different glaucoma stages. METHODS: Microvascular images and peripapillary retinal nerve fibre layer (pRNFL) thicknesses were obtained using a Cirrus OCT-A device in 91 glaucoma subjects. The pVD was measured at various spatial locations according to the Garway-Heath map, using a MATLAB software (The MathWorks, Natick, Massachusetts)...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430332/relationship-between-corneal-biomechanical-properties-and-optic-nerve-head-changes-after-deep-sclerectomy
#5
Laura Díez-Álvarez, Francisco J Muñoz-Negrete, Pilar Casas-Llera, Noelia Oblanca, Victoria de Juan, Gema Rebolleda
PURPOSE: To evaluate corneal biomechanical properties and optic nerve head (ONH) changes following deep sclerectomy (DS) and the relation to each other. METHODS: Forty-nine eyes with primary open-angle glaucoma that underwent DS were studied. Corneal biomechanical properties were assessed using the Ocular Response Analyzer and the ONH was evaluated by Spectralis optical coherence tomography with enhanced depth imaging technology before surgery and 3 months postoperatively...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28414805/measurements-of-the-parapapillary-atrophy-zones-in-en-face-optical-coherence-tomography-images
#6
Atsuya Miki, Yasushi Ikuno, Robert N Weinreb, Junko Yokoyama, Tomoko Asai, Shinichi Usui, Kohji Nishida
OBJECTIVE: To measure the parapapillary atrophy (PPA) area in en face images obtained with swept-source optical coherence tomography (SS-OCT), and to evaluate its relationship to glaucoma, myopia, and age in non-highly myopic subjects. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: Fifty eyes of 30 subjects with open-angle glaucoma (G group) and forty-three eyes of 26 healthy control subjects (C group). Eyes with high myopia (spherical equivalent refractive error ≤ -8 diopters or axial length ≥ 26...
2017: PloS One
https://www.readbyqxmd.com/read/28414059/a-mouse-ocular-explant-model-that-enables-the-study-of-living-optic-nerve-head-events-after-acute-and-chronic-intraocular-pressure-elevation-focusing-on-retinal-ganglion-cell-axons-and-mitochondria
#7
Elizabeth C Kimball, Mary E Pease, Matthew R Steinhart, Ericka N Oglesby, Ian Pitha, Cathy Nguyen, Harry A Quigley
We developed an explant model of the mouse eye and optic nerve that facilitates the study of retinal ganglion cell axons and mitochondria in the living optic nerve head (ONH) in an ex vivo environment. Two transgenic mouse strains were used, one expressing yellow fluorescent protein in selected axons and a second strain expressing cyan fluorescent protein in all mitochondria. We viewed an explanted mouse eye and optic nerve by laser scanning microscopy at and behind the ONH, the site of glaucoma injury. Explants from previously untreated mice were studied with the intraocular pressure (IOP) set artificially at normal or elevated levels for several hours...
April 14, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28408038/temporal-relation-between-macular-ganglion-cell-inner-plexiform-layer-loss-and-peripapillary-retinal-nerve-fiber-layer-loss-in-glaucoma
#8
Young Kook Kim, Ahnul Ha, Kyeong Ik Na, Hae Jin Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the temporal relationship between inferior macular ganglion cell-inner plexiform layer (mGCIPL) loss and corresponding peripapillary retinal nerve fiber layer (pRNFL) defect on the optical coherence tomography (OCT) deviation map in glaucoma. DESIGN: Retrospective, observational study. PARTICIPANTS: A total of 151 patients with early-stage glaucoma (visual field [VF] mean deviation between -1.5 and -5.5 decibels [dB])...
April 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28405489/three-dimensional-optical-coherence-tomography-imaging-and-treatment-of-glaucomatous-optic-nerve-head-defects-associated-with-schisis-like-maculopathy
#9
Zafer Öztaş, Jale Menteş, Halil Ateş, Serhad Nalçacı
We present the three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) findings of schisis-like maculopathy associated with structural changes of the optic nerve (ON) head as well as the treatment outcomes of a case of advanced glaucoma. In addition to ophthalmological examination, B-scan and 3D-SD-OCT images of the ON head, peripapillary retina, and the macula were obtained. The B-scan images only detected typical retinoschisis findings. However, the 3D-SD-OCT images of the ON head revealed defects of various sizes, shapes, and depths at the outer wall of the prelaminar and laminar regions of the ON canal...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28395028/reflectance-spectrum-and-birefringence-of-the-retinal-nerve-fiber-layer-with-hypertensive-damage-of-axonal-cytoskeleton
#10
Xiang-Run Huang, Robert W Knighton, Ye Z Spector, Jianzhong Qiao, Wei Kong, Qi Zhao
Purpose: Glaucoma damages the retinal nerve fiber layer (RNFL). This study used precise multimodal image registration to investigate the changes of the RNFL reflectance spectrum and birefringence in nerve fiber bundles with different degrees of axonal damage. Methods: The reflectance spectrum of individual nerve fiber bundles in normal rats and rats with experimental glaucoma was measured from 400 to 830 nm and their birefringence was measured at 500 nm. Optical measurements of the same bundles were made at different distances from the optic nerve head (ONH)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28389675/deformation-of-the-lamina-cribrosa-and-optic-nerve-due-to-changes-in-cerebrospinal-fluid-pressure
#11
Andrew J Feola, Baptiste Coudrillier, John Mulvihill, Diogo M Geraldes, Nghia T Vo, Julie Albon, Richard L Abel, Brian C Samuels, C Ross Ethier
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28383403/influence-of-the-lamina-cribrosa-on-the-rate-of-global-and-localized-retinal-nerve-fiber-layer-thinning-in-open-angle-glaucoma
#12
Hae-Young Lopilly Park, Sung In Kim, Chan Kee Park
The advent of optical coherence tomography (OCT) imaging allows identification of the structural contribution of the lamina cribrosa (LC) to glaucoma progression. This study aimed to determine the role of various LC features, such as the LC depth (LCD), LC thickness (LCT), and focal LC defects, on the future rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with glaucoma. One hundred eighteen patients with glaucoma who had undergone at least 4 OCT examinations were included. Features of LC, including the LCD, LCT, and presence of focal LC defects, from serial scan of the optic disc using the enhanced depth imaging of Spectralis OCT; were analyzed at baseline...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28353690/impact-of-rates-of-change-of-lamina-cribrosa-and-optic-nerve-head-surface-depths-on-visual-field-progression-in-glaucoma
#13
Zhongheng Wu, Chen Lin, Michael Crowther, Heather Mak, Marco Yu, Christopher K-S Leung
Purpose: To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. Methods: One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at approximately 4-month intervals for greater than or equal to 5 years. Anterior lamina cribrosa surface depth and ONHSD were measured with reference to (1) Bruch's membrane opening (BMO), and (2) choroid-sclera interface (CSI)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28349763/radiographic-evidence-of-occult-intracranial-hypertension-in-patients-with-m%C3%A3-ni%C3%A3-re-s-disease
#14
Kareem O Tawfik, Shawn M Stevens, David Mihal, Mark S Costello, Rebecca S Cornelius, Ravi N Samy, Myles L Pensak
Objectives (1) Describe the prevalence of radiographic signs of intracranial hypertension (ICH) in Ménière's disease (MD) and (2) compare the prevalence of radiographic signs of ICH in MD patients managed medically to those managed surgically. Study Design Case-control study. Setting Academic neurotologic practice. Subjects and Methods Adult MD patients (aged ≥17 years) treated from 2011 to 2015 were reviewed. Inclusion required magnetic resonance imaging (MRI) of the head and follow-up >6 months. Patients with intracranial tumors, mass effect, trauma, previous intracranial surgery, and glaucoma were excluded...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28319525/crowdsourcing-to-evaluate-fundus-photographs-for-the-presence-of-glaucoma
#15
Xueyang Wang, Lucy I Mudie, Mani Baskaran, Ching-Yu Cheng, Wallace L Alward, David S Friedman, Christopher J Brady
PURPOSE: To assess the accuracy of crowdsourcing for grading optic nerve images for glaucoma using Amazon Mechanical Turk before and after training modules. MATERIALS AND METHODS: Images (n=60) from 2 large population studies were graded for glaucoma status and vertical cup-to-disc ratio (VCDR). In the baseline trial, users on Amazon Mechanical Turk (Turkers) graded fundus photos for glaucoma and VCDR after reviewing annotated example images. In 2 additional trials, Turkers viewed a 26-slide PowerPoint training or a 10-minute video training and passed a quiz before being permitted to grade the same 60 images...
March 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28297027/underlying-microstructure-of-parapapillary-deep-layer-capillary-dropout-identified-by-optical-coherence-tomography-angiography
#16
Eun Ji Lee, Tae-Woo Kim, Seung Hyen Lee, Jung-Ah Kim
Purpose: To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). Methods: Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28283025/ganglion-cell-inner-plexiform-layer-and-retinal-nerve-fiber-layer-thickness-according-to-myopia-and-optic-disc-area-a-quantitative-and-three-dimensional-analysis
#17
Sam Seo, Chong Eun Lee, Jae Hoon Jeong, Ki Ho Park, Dong Myung Kim, Jin Wook Jeoung
BACKGROUND: To determine the influences of myopia and optic disc size on ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness profiles obtained by spectral domain optical coherence tomography (OCT). METHODS: One hundred and sixty-eight eyes of 168 young myopic subjects were recruited and assigned to one of three groups according to their spherical equivalent (SE) values and optic disc area. All underwent Cirrus HD-OCT imaging...
March 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28280481/the-optic-canal-a-bottleneck-for-cerebrospinal-fluid-dynamics-in-normal-tension-glaucoma
#18
Achmed Pircher, Margherita Montali, Jatta Berberat, Luca Remonda, Hanspeter E Killer
PURPOSE: To report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases. METHODS: Retrospective analysis of computed tomographic images of the cranium and orbits in 56 NTG patients (30 females and 26 males; 99 of 112 eyes; mean age 67.7 ± 11.1 years). Fifty-six age- and gender-matched subjects (mean age: 68.0 ± 11.2 years) without known ON diseases served as controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28265105/glioprotection-of-retinal-astrocytes-after-intravitreal-administration-of-memantine-in-the-mouse-optic-nerve-crush-model
#19
Ruta Maciulaitiene, Giedre Pakuliene, Simon Kaja, Dainius Haroldas Pauza, Giedrius Kalesnykas, Ingrida Januleviciene
BACKGROUND In glaucoma, non-intraocular pressure (IOP)-related risk factors can result in increased levels of extracellular glutamate, which triggers a cascade of neurodegeneration characterized by the excessive activation of N-methyl-D-aspartate (NMDA). The purpose of our study was to evaluate the glioprotective effects of memantine as a prototypic uncompetitive NMDA blocker on retinal astrocytes in the optic nerve crush (ONC) mouse model for glaucoma. MATERIAL AND METHODS Optic nerve crush was performed on all of the right eyes (n=8), whereas left eyes served as contralateral healthy controls (n=8) in Balb/c/Sca mice...
March 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28263263/optical-coherence-tomography-and-glaucoma-progression-a-comparison-of-a-region-of-interest-approach-to-average-retinal-nerve-fiber-layer-thickness
#20
Abinaya Thenappan, Carlos Gustavo De Moraes, Diane L Wang, Daiyan Xin, Ravivarn Jarukasetphon, Robert Ritch, Donald C Hood
PURPOSE: To determine whether the change in the retinal nerve fiber layer (RNFL) thickness in a region of interest (ROI) is a better measure of glaucoma progression than the change in average circumpapillary (cp) RNFL thickness. METHODS: Disc cube scans were obtained with frequency domain optical coherence tomography from 60 eyes of 60 patients (age, 61.7±12.7 y) with early or suspected glaucoma and controlled intraocular pressure. The average time between 2 test dates was 3...
May 2017: Journal of Glaucoma
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