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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#1
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27916682/adaptive-optics-optical-coherence-tomography-in-glaucoma
#2
REVIEW
Zachary M Dong, Gadi Wollstein, Bo Wang, Joel S Schuman
Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT...
December 1, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27914978/estimating-oct-structural-measurement-floors-to-improve-detection-of-progression-in-advanced-glaucoma
#3
Christopher Bowd, Linda M Zangwill, Robert N Weinreb, Felipe A Medeiros, Akram Belghith
PURPOSE: "Floor effects" in retinal imaging are defined as the points at which no further structural loss can be detected. We estimated the measurement floors for spectral-domain optical coherence tomography (SD-OCT) measurements and compared global change over time in advanced glaucoma eyes. DESIGN: Validity study to investigate measurement floors. METHODS: A longitudinal "Variability Group" of 41 eyes with moderate to advanced glaucoma (SAP MD ≤ -8 dB) was used to estimate measurement floors...
November 30, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27899368/diagnostic-ability-of-peripapillary-vessel-density-measurements-of-optical-coherence-tomography-angiography-in-primary-open-angle-and-angle-closure-glaucoma
#4
Harsha L Rao, Sujatha V Kadambi, Robert N Weinreb, Narendra K Puttaiah, Zia S Pradhan, Dhanaraj A S Rao, Rajesh S Kumar, Carroll A B Webers, Rohit Shetty
AIMS: To evaluate the diagnostic ability of peripapillary vessel density measurements on optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and to compare these with peripapillary retinal nerve fibre layer (RNFL) thickness measurements. METHODS: In a cross-sectional study, 48 eyes of 33 healthy control subjects, 63 eyes of 39 patients with POAG and 49 eyes of 32 patients with PACG underwent OCTA (RTVue-XR, Optovue, Fremont, California, USA) and RNFL imaging with spectral domain OCT...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898471/green-disease-in-optical-coherence-tomography-diagnosis-of-glaucoma
#5
Mohamed S Sayed, Michael Margolis, Richard K Lee
PURPOSE OF REVIEW: Optical coherence tomography (OCT) has become an integral component of modern glaucoma practice. Utilizing color codes, OCT analysis has rendered glaucoma diagnosis and follow-up simpler and faster for the busy clinician. However, green labeling of OCT parameters suggesting normal values may confer a false sense of security, potentially leading to missed diagnoses of glaucoma and/or glaucoma progression. RECENT FINDINGS: Conditions in which OCT color coding may be falsely negative (i...
November 24, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27898445/pathologic-myopia
#6
Kyoko Ohno-Matsui
Pathologic myopia (PM) is the only myopia that causes the loss of best-corrected visual acuity. The main reason for best-corrected visual acuity loss is complications specific to PM, such as myopic maculopathy, myopic traction maculopathy, and myopic optic neuropathy (or glaucoma). The meta-analyses of the PM study group (META-PM study) made a classification system for myopic maculopathy. On the basis of this study, PM has been defined as eyes having atrophic changes equal to or more severe than diffuse atrophy...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27895937/medical-management-of-glaucoma-in-the-21st-century-from-a-canadian-perspective
#7
REVIEW
Paul Harasymowycz, Catherine Birt, Patrick Gooi, Lisa Heckler, Cindy Hutnik, Delan Jinapriya, Lesya Shuba, David Yan, Radmila Day
Glaucoma is a medical term describing a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and resulting in changes in the optic nerve head. Glaucoma is a leading cause of irreversible vision loss worldwide. With the aging population it is expected that the prevalence of glaucoma will continue to increase. Despite recent advances in imaging and visual field testing techniques that allow establishment of earlier diagnosis and treatment initiation, significant numbers of glaucoma patients are undiagnosed and present late in the course of their disease...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847691/a-single-wide-field-oct-protocol-can-provide-compelling-information-for-the-diagnosis-of-early-glaucoma
#8
Donald C Hood, Nicole De Cuir, Dana M Blumberg, Jeffrey M Liebmann, Ravivarn Jarukasetphon, Robert Ritch, Carlos G De Moraes
PURPOSE: To evaluate a report for glaucoma diagnosis based on a single optical coherence tomography (OCT) protocol. METHODS: A wide-field (9 × 12 mm) swept-source (SS) OCT scan, encompassing the macula and disc, was obtained on 130 eyes (patients) with or suspected open-angle glaucoma, a mean deviation greater than or equal to -6 dB on a 24-2 visual field (VF), and spherical refractive error between ± 6 diopters (D). The single-page report contained a circumpapillary retinal nerve fiber layer (cpRNFL) thickness plot; retinal ganglion cell layer and retinal nerve fiber layer (RNFL) thickness and probability plots of the macula and optic nerve; and an enface slab image of the optic nerve...
November 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27834967/peripapillary-schisis-in-open-angle-glaucoma
#9
N Dhingra, R Manoharan, S Gill, M Nagar
PurposeTo report clinical features, topographic findings and outcome of 10 eyes with peripapillary schisis in open-angle glaucoma.Patients and methodsA retrospective review of patients with open-angle glaucoma who were noted to have peripapillary schisis on optical coherence tomography (OCT) were included. Serial peripapillary and macula infrared and OCT images, visual acuity, visual fields, and schisis appearance were reviewed.ResultsTen eyes of nine patients with open-angle glaucoma were detected to have the presence of peripapillary schisis...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27834960/diagnostic-ability-of-humphrey-perimetry-octopus-perimetry-and-optical-coherence-tomography-for-glaucomatous-optic-neuropathy
#10
B Monsalve, A Ferreras, P Calvo, J A Urcola, M Figus, J Monsalve, P Frezzotti
PurposeTo evaluate and compare the diagnostic accuracy of the Humphrey Field Analyzer (HFA), Octopus perimetry, and Cirrus OCT for glaucomatous optic neuropathy.MethodsEighty-eight healthy individuals and 150 open-angle glaucoma patients were consecutive and prospectively selected. Eligibility criteria for the glaucoma group were intraocular pressure ≥21 mm Hg and glaucomatous optic nerve head morphology. All subjects underwent a reliable standard automated perimetry with the HFA and Octopus perimeter, and were imaged with the Cirrus OCT...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27820876/discriminant-function-of-optical-coherence-tomography-angiography-to-determine-disease-severity-in-glaucoma
#11
Rajesh S Kumar, Neha Anegondi, Rachana S Chandapura, Suria Sudhakaran, Sujatha V Kadambi, Harsha L Rao, Tin Aung, Abhijit Sinha Roy
Purpose: To determine the discriminant function of optical coherence tomography angiography (OCTA) by disease severity in glaucoma. Methods: In this prospective, observational cross-sectional study, all subjects underwent visual fields, retinal nerve fiber layer (RNFL) measurements, and OCTA imaging. Local fractal analysis was applied to OCTA images (radial peripapillary capillaries [RPC] layer). Vessel density en face and inside the disc and spacing between large and small vessels were quantified...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27814326/consistency-of-bruch-membrane-opening-detection-as-determined-by-optical-coherence-tomography
#12
Young Hoon Hwang, Min K Kim, Sang I Ahn
PURPOSE: To investigate the consistency of Bruch membrane opening (BMO) detection as determined by Cirrus high-definition optical coherence tomography (OCT). MATERIALS AND METHODS: This study enrolled 106 healthy eyes and 194 glaucomatous eyes who underwent OCT examinations. The location of BMO was evaluated by inspecting 72 cross-sectional optic nerve head (ONH) images (5 degrees intervals for 360 degrees) per eye in which BMO location is automatically detected by the OCT algorithm...
November 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27764824/intra-and-inter-rater-agreement-of-anterior-lamina-cribrosa-depth-measurements-using-enhanced-depth-imaging-optical-coherence-tomography
#13
Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27755347/optic-disc-characteristics-and-visual-field-progression-in-normal-tension-glaucoma-patients-with-tilted-optic-discs
#14
Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
November 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27742922/optical-coherence-tomography-angiography-analysis-of-perfused-peripapillary-capillaries-in-primary-open-angle-glaucoma-and-normal-tension-glaucoma
#15
Nicole K Scripsema, Patricia M Garcia, Richard D Bavier, Toco Y P Chui, Brian D Krawitz, Shelley Mo, Steven A Agemy, Luna Xu, Yijie B Lin, Joseph F Panarelli, Paul A Sidoti, James C Tsai, Richard B Rosen
Purpose: To compare perfused peripapillary capillary density in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and normal patients using optical coherence tomography angiography (OCT-A). Methods: A retrospective review of POAG, NTG, and normal patients imaged with OCT-A was performed. En face OCT angiograms identifying peripapillary vessels were obtained using a spectral-domain OCT system (Avanti RTVue-XR). A custom image analysis approach identified perfused peripapillary capillaries, quantified perfused capillary density (PCD), and generated color-coded PCD maps for 3...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27726964/relationship-between-optical-coherence-tomography-angiography-vessel-density-and-severity-of-visual-field-loss-in-glaucoma
#16
Adeleh Yarmohammadi, Linda M Zangwill, Alberto Diniz-Filho, Min Hee Suh, Siamak Yousefi, Luke J Saunders, Akram Belghith, Patricia Isabel C Manalastas, Felipe A Medeiros, Robert N Weinreb
PURPOSE: To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 153 eyes from 31 healthy participants, 48 glaucoma suspects, and 74 glaucoma patients enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: All eyes underwent imaging using OCT-A (Angiovue; Optovue, Fremont, CA), spectral-domain OCT (Avanti; Optovue), and standard automated perimetry (SAP)...
October 7, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27707691/optical-coherence-tomography-angiography-an-overview-of-the-technology-and-an-assessment-of-applications-for-clinical-research
#17
Andrew Koustenis, Alon Harris, Josh Gross, Ingrida Januleviciene, Aaditya Shah, Brent Siesky
In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies...
October 4, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27689896/atlas-based-shape-analysis-and-classification-of-retinal-optical-coherence-tomography-images-using-the-functional-shape-fshape-framework
#18
Sieun Lee, Nicolas Charon, Benjamin Charlier, Karteek Popuri, Evgeniy Lebed, Marinko V Sarunic, Alain Trouvé, Mirza Faisal Beg
We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be measured by the geometrical deformation and functional residual between the template and each of the observations...
September 20, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27682504/optic-nerve-head-slope-based-quantitative-parameters-for-identifying-open-angle-glaucoma-on-spectralis-oct-images
#19
Abdel-Razzak M Al-Hinnawi, Bassam O Al-Naami, Motasem M Al-Latayfeh
PURPOSE: To investigate monitoring slope-based features of the optic nerve head (ONH) cup as open-angle glaucoma (OAG) occurs. METHOD: A dataset of 46 retrospective OCT cases was acquired from the SPECTRALIS Heidelberg Engineering OCT device. A set of five parameters, which are based on the ONH cup-incline, are measured on the OAG and normal subjects in the dataset. Then, three new ONH cup-shape indices were deduced. The ONH cup-incline parameters and ONH cup-shape indices are analyzed to estimate their clinical value...
September 28, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27661989/mri-study-of-the-posterior-visual-pathways-in-primary-open-angle-glaucoma
#20
Wei Zhou, Eric R Muir, Steven Chalfin, Kundandeep S Nagi, Timothy Q Duong
PURPOSE OF THE STUDY: The purpose of the study was to evaluate neurodegeneration along brain visual pathways in primary open angle glaucoma (POAG) using improved analysis methods of volumetric and diffusion tensor magnetic resonance imaging (MRI) data. METHODS: Eleven POAG patients (60.0±9.2 y) with primarily mild to moderate POAG and 11 age-matched controls (55.9±7.5 y) were studied using structural and diffusion tensor MRI. Surface-based segmentation was applied to structural MRI to obtain visual cortical area and volume...
September 21, 2016: Journal of Glaucoma
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