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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/29140817/new-developments-in-optical-coherence-tomography-imaging-for-glaucoma
#1
Jean-Claude Mwanza, Donald L Budenz
PURPOSE OF REVIEW: Since its introduction in ophthalmology, optical coherence tomography (OCT) has undergone significant advances in imaging protocols, algorithms, and addition of new parameters which have maximized its potential for diagnosing, evaluating the response to treatment, and assessing the progression of various ocular diseases, including glaucoma. This review provides an update on recent developments in OCT with respect to the management of glaucoma. RECENT FINDINGS: Most recent notable developments include the introduction of the minimum distance band, which is a three-dimensional optic nerve head parameter, and Swept-Source OCT with its single wide-field scanning capability...
November 14, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29120259/signal-alteration-in-the-optic-nerve-head-on-3d-t2-weighted-mri-a-potential-neuroimaging-sign-of-glaucomatous-optic-neuropathy
#2
Jong Yeon Lee, Hyo Jeong Kwon, Su Jin Park, Chungkwon Yoo, Yong Yeon Kim, Eung Yeop Kim
PURPOSE: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively...
November 9, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29109895/are-all-retinal-nerve-fiber-layer-defects-on-optic-coherence-tomography-glaucomatous
#3
Sirel Gür Güngör, Akman Ahmet
Objectives: In this study, we investigated the patients who were referred to our clinic with a prediagnosis of glaucoma based on retinal nerve fiber layer (RNFL) defects on optic coherence tomography (OCT) but were determined to have nonglaucomatous RNLF defects upon detailed examination. Materials and Methods: The ophthalmic examination notes, OCT images, Heidelberg retinal tomography (HRT) II and fundus photographs of 357 patients were retrospectively evaluated...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29101405/parapapillary-deep-layer-microvasculature-dropout-in-primary-open-angle-glaucoma-eyes-with-a-parapapillary-%C3%AE-zone
#4
Eun Ji Lee, Tae-Woo Kim, Ji-Ah Kim, Jeong-Ah Kim
Purpose: To explore the clinical characteristics of parapapillary deep-layer microvasculature dropout (MvD) associated with parapapillary γ-zone in primary open-angle glaucoma (POAG). Methods: A total of 150 eyes with POAG and 75 age- and axial length-matched control eyes, both having parapapillary γ-zone as determined by spectral-domain (SD) optical coherence tomography (OCT), were included. Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en-face images obtained using swept-source OCT angiography (OCTA)...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29077716/evaluation-of-retinal-nerve-fiber-layer-defect-using-wide-field-en-face-swept-source-oct-images-by-applying-the-inner-limiting-membrane-flattening
#5
Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa
PURPOSE: The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. METHODS: This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity < 0.5, axial length > 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field...
2017: PloS One
https://www.readbyqxmd.com/read/29055905/macular-imaging-by-optical-coherence-tomography-in-the-diagnosis-and-management-of-glaucoma
#6
REVIEW
Ko Eun Kim, Ki Ho Park
The macular area is important to the detection of glaucomatous retinal ganglion cell (RGC) damage. Macular thickness complementary to peripapillary retinal nerve fibre layer (RNFL) thickness can well reflect glaucomatous damage, given that the macula contains more than 50% of the RGCs in a multilayered pattern and larger RGC bodies compared with their axons. Thus, macular ganglion cell thickness parameters recently have been considered to be an effective glaucoma-diagnostic tool comparable to RNFL thickness parameters...
October 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040280/quantitative-analysis-of-neural-tissues-around-the-optic-disc-after-panretinal-photocoagulation-in-patients-with-diabetic-retinopathy
#7
Hyun Seung Yang, June-Gone Kim, Jae Bong Cha, Young In Yun, Jong Hoon Park, Jong Eun Woo
In this retrospective cross-sectional study, we quantitatively analyzed the tomographic features in the neural tissues around the optic disc in patients with diabetic retinopathy with and without panretinal photocoagulation. We analyzed 206 eyes, comprising 33 normal eyes in subjects without diabetes (group I), 30 eyes without diabetic retinopathy (group II), 66 eyes with non-proliferative diabetic retinopathy (group III), 45 eyes with panretinal photocoagulation (group IV), and 32 eyes with normal tension glaucoma (group V)...
2017: PloS One
https://www.readbyqxmd.com/read/29027590/diagnostic-utility-of-combined-retinal-ganglion-cell-count-estimates-in-japanese-glaucoma-patients
#8
Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
PURPOSE: To assess the combined estimate of retinal ganglion cell (RGC) count developed by Medeiros et al. as a tool for diagnosis of glaucoma in Japanese patients. STUDY DESIGN: Cross-sectional study. METHODS: Thirty-one eyes of 19 healthy controls and 106 eyes of 70 glaucoma patients underwent standard automated perimetry (SAP) and three types of spectral domain optical coherence tomography (SD-OCT) imaging using the Cirrus, RTVue, and 3D-OCT instruments...
October 13, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29016521/glaucoma-diagnostic-capabilities-of-foveal-avascular-zone-parameters-using-optical-coherence-tomography-angiography-according-to-visual-field-defect-location
#9
Junki Kwon, Jaewan Choi, Joong Won Shin, Jiyun Lee, Michael S Kook
PURPOSE: To assess the diagnostic ability of foveal avascular zone (FAZ) parameters to discriminate glaucomatous eyes with visual field defects (VFDs) in different locations (central vs. peripheral) from normal eyes. PATIENTS AND METHODS: Totally, 125 participants were separated into three groups: normal (n=45), glaucoma with peripheral VFD (PVFD, n=45), and glaucoma with central VFD (CVFD, n=35). The FAZ area, perimeter, and circularity and parafoveal vessel density were calculated from optical coherence tomography angiography images...
October 9, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28991833/optical-coherence-tomography-angiography-vessel-density-measurements-in-eyes-with-primary-open-angle-glaucoma-and-disc-hemorrhage
#10
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll A B Webers
PURPOSE: To compare the vessel density measurements of optic nerve head, peripapillary and macular regions in severity-matched primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography, and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT. METHODS: In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation=-3...
October 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28986311/glaucoma-and-the-brain-trans-synaptic-degeneration-structural-change-and-implications-for-neuroprotection
#11
REVIEW
Mitchell Lawlor, Helen Danesh-Meyer, Leonard A Levin, Indran Davagnanam, Enrico De Vita, Gordon T Plant
A recent hypothesis to enter the literature suggests that glaucoma is a neuro-degenerative disease. The basis for this has been the finding of central nervous system (CNS) changes in glaucoma patients on histology and neuro-imaging. It is known that retinal ganglion cell (RGC) pathology of any cause leads to anterograde and retrograde RGC degeneration, as well as trans-synaptic (trans-neuronal) anterograde degeneration. Trans-synaptic degeneration has been demonstrated in a range of optic neuropathies including optic nerve transection, optic neuritis, and hereditary optic neuropathies...
October 3, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28984709/measurement-of-optic-disc-cup-surface-depth-using-cirrus-hd-oct
#12
Young Kook Kim, Ahnul Ha, Won June Lee, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To introduce the measurement method of optic disc cup surface depth using spectral-domain optical coherence tomography (SD-OCT) and then evaluate the rates of cup surface depression at three different stages of glaucoma. METHODS: We retrospectively identified 52 eyes with preperimetric glaucoma, 56 with mild-or-moderate glaucoma and 50 with severe glaucoma and followed them for at least 48 months. Eyes were imaged using SD-OCT (Cirrus™ HD-OCT) at 12-month intervals...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28964806/comparison-of-glaucoma-progression-detection-by-optical-coherence-tomography-and-visual-field
#13
Xinbo Zhang, Anna Dastiridou, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, David Huang
PURPOSE: To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). DESIGN: Validity assessment METHOD: We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as a significant negative trend for either NFL or GCC...
September 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28952978/clinical-implications-of-in-vivo-lamina-cribrosa-imaging-in-glaucoma
#14
Yong Woo Kim, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park
The lamina cribrosa (LC) is a multilayered, collagenous, sieve-like structure at the deep optic nerve head, and is presumed to be the primary site of axonal injury. According to biomechanical theory, intraocular pressure-induced posterior deformation of the LC causes blockage of axonal transport and alters the ocular blood flow, so that the axons of the retinal ganglion cells lead to apoptosis, which results in glaucomatous optic disc change. Although most of the research on the LC to date has been limited to experimental animal or histologic studies, the recent advances in optical coherence tomography devices and image processing techniques have made possible the visualization of the LC structure in vivo...
August 4, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28947898/an-automatic-image-processing-system-for-glaucoma-screening
#15
Ahmed Almazroa, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
Horizontal and vertical cup to disc ratios are the most crucial parameters used clinically to detect glaucoma or monitor its progress and are manually evaluated from retinal fundus images of the optic nerve head. Due to the rarity of the glaucoma experts as well as the increasing in glaucoma's population, an automatically calculated horizontal and vertical cup to disc ratios (HCDR and VCDR, resp.) can be useful for glaucoma screening. We report on two algorithms to calculate the HCDR and VCDR. In the algorithms, level set and inpainting techniques were developed for segmenting the disc, while thresholding using Type-II fuzzy approach was developed for segmenting the cup...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28941529/emerging-applications-of-optical-coherence-tomography-in-pediatric-optic-neuropathies
#16
Sidney M Gospe, M Tariq Bhatti, Mays A El-Dairi
Limited cooperation and attention span often lead to poorly reliable assessments of visual acuity and visual fields in children, making diagnosis and monitoring of pediatric optic neuropathies challenging. As a noninvasive imaging modality, optical coherence tomography (OCT) could offer particular utility in this patient population. OCT provides high-resolution characterization of the optic nerve head, peripapillary retinal nerve fiber layer, and cellular layers of the macula, all of which can be used to assess the severity of optic nerve disease qualitatively and quantitatively...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#17
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28931182/-primary-open-angle-glaucoma
#18
Esther M Hoffmann, Verena Prokosch-Willing
Glaucoma leads to blindness but there are diagnostic and therapeutic developments that aid ophthalmologists in the improved mangement of the disease compared to the past. Known risk factors such as age, myopia, dark pigmented skin, genetics, and elevated intraocular pressure play an important role for the individual patient's prognosis, and many yet unknown or not sufficiently investigated risk factors come along. The structured examination of the optic nerve head is crucial for the clincial diagnosis by the ophthalmologist...
September 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28929241/assessment-of-peripapillary-choroidal-thickness-in-primary-open-angle-glaucoma-patients-with-choroidal-vascular-prominence
#19
COMPARATIVE STUDY
Yong Ju Song, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the relationship between peripapillary choroidal thickness (PCT) and choroidal vascular prominence (CVP) colocalized with retinal nerve fiber layer (RNFL) defect in primary open-angle glaucoma (POAG) eyes and to evaluate the relationship between PCT and POAG severity. METHODS: In this cross-sectional comparative study, 29 POAG patients with CVP on RNFL imaging (Group A), 70 POAG patients without CVP (Group B) and 63 healthy controls (Group C) were examined...
November 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#20
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
November 2017: Current Eye Research
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