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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/28319525/crowdsourcing-to-evaluate-fundus-photographs-for-the-presence-of-glaucoma
#1
Xueyang Wang, Lucy I Mudie, Mani Baskaran, Ching-Yu Cheng, Wallace L Alward, David S Friedman, Christopher J Brady
PURPOSE: To assess the accuracy of crowdsourcing for grading optic nerve images for glaucoma using Amazon Mechanical Turk before and after training modules. MATERIALS AND METHODS: Images (n=60) from 2 large population studies were graded for glaucoma status and vertical cup-to-disc ratio (VCDR). In the baseline trial, users on Amazon Mechanical Turk (Turkers) graded fundus photos for glaucoma and VCDR after reviewing annotated example images. In 2 additional trials, Turkers viewed a 26-slide PowerPoint training or a 10-minute video training and passed a quiz before being permitted to grade the same 60 images...
March 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28297027/underlying-microstructure-of-parapapillary-deep-layer-capillary-dropout-identified-by-optical-coherence-tomography-angiography
#2
Eun Ji Lee, Tae-Woo Kim, Seung Hyen Lee, Jung-Ah Kim
Purpose: To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). Methods: Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28283025/ganglion-cell-inner-plexiform-layer-and-retinal-nerve-fiber-layer-thickness-according-to-myopia-and-optic-disc-area-a-quantitative-and-three-dimensional-analysis
#3
Sam Seo, Chong Eun Lee, Jae Hoon Jeong, Ki Ho Park, Dong Myung Kim, Jin Wook Jeoung
BACKGROUND: To determine the influences of myopia and optic disc size on ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness profiles obtained by spectral domain optical coherence tomography (OCT). METHODS: One hundred and sixty-eight eyes of 168 young myopic subjects were recruited and assigned to one of three groups according to their spherical equivalent (SE) values and optic disc area. All underwent Cirrus HD-OCT imaging...
March 11, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28280481/the-optic-canal-a-bottleneck-for-cerebrospinal-fluid-dynamics-in-normal-tension-glaucoma
#4
Achmed Pircher, Margherita Montali, Jatta Berberat, Luca Remonda, Hanspeter E Killer
PURPOSE: To report on the optic canal cross-sectional area (OCA) in Caucasian patients with normal-tension glaucoma (NTG) compared with Caucasian control subjects without known optic nerve (ON) diseases. METHODS: Retrospective analysis of computed tomographic images of the cranium and orbits in 56 NTG patients (30 females and 26 males; 99 of 112 eyes; mean age 67.7 ± 11.1 years). Fifty-six age- and gender-matched subjects (mean age: 68.0 ± 11.2 years) without known ON diseases served as controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28265105/glioprotection-of-retinal-astrocytes-after-intravitreal-administration-of-memantine-in-the-mouse-optic-nerve-crush-model
#5
Ruta Maciulaitiene, Giedre Pakuliene, Simon Kaja, Dainius Haroldas Pauza, Giedrius Kalesnykas, Ingrida Januleviciene
BACKGROUND In glaucoma, non-intraocular pressure (IOP)-related risk factors can result in increased levels of extracellular glutamate, which triggers a cascade of neurodegeneration characterized by the excessive activation of N-methyl-D-aspartate (NMDA). The purpose of our study was to evaluate the glioprotective effects of memantine as a prototypic uncompetitive NMDA blocker on retinal astrocytes in the optic nerve crush (ONC) mouse model for glaucoma. MATERIAL AND METHODS Optic nerve crush was performed on all of the right eyes (n=8), whereas left eyes served as contralateral healthy controls (n=8) in Balb/c/Sca mice...
March 7, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28263263/optical-coherence-tomography-and-glaucoma-progression-a-comparison-of-a-region-of-interest-approach-to-average-retinal-nerve-fiber-layer-thickness
#6
Abinaya Thenappan, Carlos Gustavo De Moraes, Diane L Wang, Daiyan Xin, Ravivarn Jarukasetphon, Robert Ritch, Donald C Hood
PURPOSE: To determine whether the change in the retinal nerve fiber layer (RNFL) thickness in a region of interest (ROI) is a better measure of glaucoma progression than the change in average circumpapillary (cp) RNFL thickness. METHODS: Disc cube scans were obtained with frequency domain optical coherence tomography from 60 eyes of 60 patients (age, 61.7±12.7 y) with early or suspected glaucoma and controlled intraocular pressure. The average time between 2 test dates was 3...
March 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28254626/vessel-density-and-structural-measurements-of-optical-coherence-tomography-in-primary-angle-closure-and-primary-angle-closure-glaucoma
#7
Harsha L Rao, Zia S Pradhan, Robert N Weinreb, Mohammed Riyazuddin, Srilakshmi Dasari, Jayasree P Venugopal, Narendra K Puttaiah, Dhanaraj A S Rao, Sathi Devi, Kaweh Mansouri, Carroll Ab Webers
PURPOSE: To evaluate the vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary angle closure (PAC) and primary angle closure glaucoma (PACG), and to compare their diagnostic abilities with the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements on OCT in PACG. DESIGN: Cross-sectional study METHODS: Seventy-seven eyes of 50 control subjects, 65 eyes of 45 patients with PACG, and 31 eyes of 22 PAC patients with a history of high IOP, underwent imaging with OCT...
February 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251307/-diffusion-tensor-imaging-of-the-visual-pathway-in-glaucomatous-optic-nerve-atrophy
#8
REVIEW
T Engelhorn, M A Schmidt, A Dörfler, G Michelson
In Germany more than one million inhabitants suffer from glaucoma, more than 100,000 are threatened with blindness because glaucoma is often diagnosed too late or not at all. Diagnosis and monitoring is usually carried out "only" by examination of the retina and not the whole visual pathway. However, the eye is just "the tip of the iceberg" of the actual visual pathway, which extends through the brain to the visual cortex. The interdisciplinary holistic assessment of the whole visual pathway in glaucoma is of crucial importance because glaucoma is a complex neurodegenerative disease...
March 1, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28251085/short-duration-transient-visual-evoked-potentials-and-color-reflectivity-discretization-analysis-in-glaucoma-patients-and-suspects
#9
Michael Waisbourd, Rebekah H Gensure, Ardalan Aminlari, Sonya B Shah, Nitasha Khanna, Neil Sood, Jeanne Molineaux, Alberto Gonzalez, Jonathan S Myers, L Jay Katz
AIM: To evaluate the use of short-duration transient visual evoked potentials (VEP) and color reflectivity discretization analysis (CORDA) in glaucomatous eyes, eyes suspected of having glaucoma, and healthy eyes. METHODS: The study included 136 eyes from 136 subjects: 49 eyes with glaucoma, 45 glaucoma suspect eyes, and 42 healthy eyes. Subjects underwent Humphrey visual field (VF) testing, VEP testing, as well as peripapillary retinal nerve fiber layer optical coherence tomography imaging studies with post-acquisition CORDA applied...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28243057/cost-and-detection-rate-of-glaucoma-screening-with-imaging-devices-in-a-primary-care-center
#10
Alfonso Anton, Monica Fallon, Francesc Cots, María A Sebastian, Antonio Morilla-Grasa, Sergi Mojal, Xavier Castells
PURPOSE: To analyze the cost and detection rate of a screening program for detecting glaucoma with imaging devices. MATERIALS AND METHODS: In this cross-sectional study, a glaucoma screening program was applied in a population-based sample randomly selected from a population of 23,527. Screening targeted the population at risk of glaucoma. Examinations included optic disk tomography (Heidelberg retina tomograph [HRT]), nerve fiber analysis, and tonometry. Subjects who met at least 2 of 3 endpoints (HRT outside normal limits, nerve fiber index ≥30, or tonometry ≥21 mmHg) were referred for glaucoma consultation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28223179/biological-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#11
REVIEW
Ernst R Tamm, C Ross Ethier, John E Dowling, Crawford Downs, Mark H Ellisman, Steven Fisher, Brad Fortune, Marcus Fruttiger, Tatjana Jakobs, Geoffrey Lewis, Claire H Mitchell, John Morrison, Sansar C Sharma, Ian Sigal, Michael Sofroniew, Lin Wang, Janey Wiggs, Samuel Wu, Richard H Masland
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements (peripapillary sclera, scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain...
February 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28221329/relationship-between-anterior-lamina-cribrosa-surface-tilt-and-glaucoma-development-in-myopic-eyes
#12
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To evaluate the anterior lamina cribrosa (LC) surface tilt angle in myopic eyes and associate it with glaucoma development. MATERIALS AND METHODS: In this retrospective study, medical records of myopic patients referred for glaucoma examination from July 1, 2012 to March 30, 2016 were reviewed. Comprehensive ophthalmic examination including spectral-domain optical coherence tomography were performed. We measured the angle of anterior LC surface tilt against Bruch's membrane opening from optical coherence tomography images at the center of the clinical optic disc margin...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#13
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28170536/astrocytes-in-the-optic-nerve-head-of-glaucomatous-mice-display-a-characteristic-reactive-phenotype
#14
Rui Wang, Philip Seifert, Tatjana C Jakobs
Purpose: Optic nerve head astrocytes, a subtype of white-matter astrocytes, become reactive early in the course of glaucoma. It was shown recently that in the DBA/2J mouse model of inherited glaucoma optic nerve astrocytes extend new longitudinal processes into the axon bundles before ganglion cell loss becomes apparent. The present study aims at testing whether this behavior of astrocytes is typical of early glaucomatous damage. Methods: Mice expressing green fluorescent protein in individual astrocytes were used to evaluate the early response of astrocytes in the glial lamina of the optic nerve head after increasing the IOP using the microbead occlusion method...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28169920/relationship-between-oct-angiography-temporal-peripapillary-vessel-density-and-octopus-perimeter-paracentral-cluster-mean-defect
#15
Gábor Holló
PURPOSE OF THE STUDY: The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect values (mean paracentral MD) measured with Octopus perimetry. MATERIALS AND METHODS: Spaerman's correlation between temporal peripapillary PAFD acquired with the Angiovue OCT and mean paracentral MD measured with the Normal and tendency-oriented perimetry strategy of Octopus G2 perimetry, respectively, was determined on 1 eye of 13 healthy participants, 22 medically controlled ocular hypertensive, and 27 stable early to moderate glaucoma patients...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28168045/transient-peripapillary-retinoschisis-in-glaucomatous-eyes
#16
Josine van der Schoot, Koenraad A Vermeer, Hans G Lemij
Purpose. To investigate transient focal microcystic retinoschisis in glaucomatous eyes in images obtained with several imaging techniques used in daily glaucoma care. Methods. Images of 117 glaucoma patients and 91 healthy subjects participating in a large prospective follow-up study into glaucoma imaging were reviewed. Participants were measured with spectral domain optical coherence tomography (SD-OCT), scanning laser polarimetry (SLP), scanning laser tomography (SLT), and standard automated perimetry (SAP)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28152106/relationship-between-optical-coherence-tomography-sector-peripapillary-angioflow-density-and-octopus-visual-field-cluster-mean-defect-values
#17
Gábor Holló
PURPOSE: To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. METHODS: High quality PAFD and RNFLT images acquired on the same day with the Angiovue/RTVue-XR Avanti OCT (Optovue Inc., Fremont, USA) on 1 eye of 27 stable early-to-moderate glaucoma, 22 medically controlled ocular hypertensive and 13 healthy participants were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28152070/retinal-vessel-density-from-optical-coherence-tomography-angiography-to-differentiate-early-glaucoma-pre-perimetric-glaucoma-and-normal-eyes
#18
Handan Akil, Alex S Huang, Brian A Francis, Sirinivas R Sadda, Vikas Chopra
PURPOSE: To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS: This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON)...
2017: PloS One
https://www.readbyqxmd.com/read/28148529/peripapillary-perfused-capillary-density-in-primary-open-angle-glaucoma-across-disease-stage-an-optical-coherence-tomography-angiography-study
#19
Lawrence S Geyman, Reena A Garg, Yanin Suwan, Vivek Trivedi, Brian D Krawitz, Shelley Mo, Alexander Pinhas, Apichat Tantraworasin, Toco Y P Chui, Robert Ritch, Richard B Rosen
AIMS: To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. METHODS: In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software...
February 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28121717/normal-tension-glaucoma-masqueraders-detection-using-optical-coherence-tomography
#20
Debbie S Kuo, Sanjay Asrani
PURPOSE: Optical coherence tomography (OCT) has become an important tool in the diagnosis and management of glaucoma; however, there can be overlap in the OCT findings between glaucoma and other diseases. We describe the clinical examination finings and interpretation of OCT imaging that led to the diagnosis of glaucoma masqueraders in a clinical case series. MATERIALS AND METHODS: Four adult patients seen in the glaucoma clinic at the Duke Eye Center were included in a retrospective observational case series...
January 24, 2017: Journal of Glaucoma
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