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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/28223179/biological-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#1
REVIEW
Ernst R Tamm, C Ross Ethier, Claude Burgoyne, C Ross Ethier, Ernst R Tamm, Cheri Stowell, John E Dowling, Crawford Downs, Mark H Ellisman, Steven Fisher, Brad Fortune, Marcus Fruttiger, Tatjana Jakobs, Geoffrey Lewis, Claire H Mitchell, John Morrison, Sansar C Sharma, Ian Sigal, Michael Sofroniew, Lin Wang, Janey Wiggs, Samuel Wu, Richard H Masland
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements (peripapillary sclera, scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain...
February 18, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28221329/relationship-between-anterior-lamina-cribrosa-surface-tilt-and-glaucoma-development-in-myopic-eyes
#2
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To evaluate the anterior lamina cribrosa (LC) surface tilt angle in myopic eyes and associate it with glaucoma development. MATERIALS AND METHODS: In this retrospective study, medical records of myopic patients referred for glaucoma examination from July 1, 2012 to March 30, 2016 were reviewed. Comprehensive ophthalmic examination including spectral-domain optical coherence tomography were performed. We measured the angle of anterior LC surface tilt against Bruch's membrane opening from optical coherence tomography images at the center of the clinical optic disc margin...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#3
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28170536/astrocytes-in-the-optic-nerve-head-of-glaucomatous-mice-display-a-characteristic-reactive-phenotype
#4
Rui Wang, Philip Seifert, Tatjana C Jakobs
Purpose: Optic nerve head astrocytes, a subtype of white-matter astrocytes, become reactive early in the course of glaucoma. It was shown recently that in the DBA/2J mouse model of inherited glaucoma optic nerve astrocytes extend new longitudinal processes into the axon bundles before ganglion cell loss becomes apparent. The present study aims at testing whether this behavior of astrocytes is typical of early glaucomatous damage. Methods: Mice expressing green fluorescent protein in individual astrocytes were used to evaluate the early response of astrocytes in the glial lamina of the optic nerve head after increasing the IOP using the microbead occlusion method...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28169920/relationship-between-oct-angiography-temporal-peripapillary-vessel-density-and-octopus-perimeter-paracentral-cluster-mean-defect
#5
Gábor Holló
PURPOSE OF THE STUDY: The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect values (mean paracentral MD) measured with Octopus perimetry. MATERIALS AND METHODS: Spaerman's correlation between temporal peripapillary PAFD acquired with the Angiovue OCT and mean paracentral MD measured with the Normal and tendency-oriented perimetry strategy of Octopus G2 perimetry, respectively, was determined on 1 eye of 13 healthy participants, 22 medically controlled ocular hypertensive, and 27 stable early to moderate glaucoma patients...
February 6, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28168045/transient-peripapillary-retinoschisis-in-glaucomatous-eyes
#6
Josine van der Schoot, Koenraad A Vermeer, Hans G Lemij
Purpose. To investigate transient focal microcystic retinoschisis in glaucomatous eyes in images obtained with several imaging techniques used in daily glaucoma care. Methods. Images of 117 glaucoma patients and 91 healthy subjects participating in a large prospective follow-up study into glaucoma imaging were reviewed. Participants were measured with spectral domain optical coherence tomography (SD-OCT), scanning laser polarimetry (SLP), scanning laser tomography (SLT), and standard automated perimetry (SAP)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28152106/relationship-between-optical-coherence-tomography-sector-peripapillary-angioflow-density-and-octopus-visual-field-cluster-mean-defect-values
#7
Gábor Holló
PURPOSE: To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. METHODS: High quality PAFD and RNFLT images acquired on the same day with the Angiovue/RTVue-XR Avanti OCT (Optovue Inc., Fremont, USA) on 1 eye of 27 stable early-to-moderate glaucoma, 22 medically controlled ocular hypertensive and 13 healthy participants were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28152070/retinal-vessel-density-from-optical-coherence-tomography-angiography-to-differentiate-early-glaucoma-pre-perimetric-glaucoma-and-normal-eyes
#8
Handan Akil, Alex S Huang, Brian A Francis, Sirinivas R Sadda, Vikas Chopra
PURPOSE: To evaluate optic nerve vascular density using swept source optical coherence tomography angiography (OCTA) in patients with early primary open angle glaucoma (POAG), pre-perimetric glaucoma and normal eyes. METHODS: This is a prospective, observational study including 56 eyes in total and divided into 3 groups; 20 eyes with mild POAG, 20 pre-perimetric glaucoma eyes, and 16 age-matched normal eyes as controls. The optic disc region was imaged by a 1050-nm-wavelength swept-source OCT system (DRI OCT Triton, TOPCON)...
2017: PloS One
https://www.readbyqxmd.com/read/28148529/peripapillary-perfused-capillary-density-in-primary-open-angle-glaucoma-across-disease-stage-an-optical-coherence-tomography-angiography-study
#9
Lawrence S Geyman, Reena A Garg, Yanin Suwan, Vivek Trivedi, Brian D Krawitz, Shelley Mo, Alexander Pinhas, Apichat Tantraworasin, Toco Y P Chui, Robert Ritch, Richard B Rosen
AIMS: To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. METHODS: In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software...
February 1, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28121717/normal-tension-glaucoma-masqueraders-detection-using-optical-coherence-tomography
#10
Debbie S Kuo, Sanjay Asrani
PURPOSE: Optical coherence tomography (OCT) has become an important tool in the diagnosis and management of glaucoma; however, there can be overlap in the OCT findings between glaucoma and other diseases. We describe the clinical examination finings and interpretation of OCT imaging that led to the diagnosis of glaucoma masqueraders in a clinical case series. MATERIALS AND METHODS: Four adult patients seen in the glaucoma clinic at the Duke Eye Center were included in a retrospective observational case series...
January 24, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28113877/automated-diagnosis-of-glaucoma-using-empirical-wavelet-transform-and-correntropy-features-extracted-from-fundus-images
#11
Shishir Maheshwari, Ram Bilas Pachori, U Rajendra Acharya
Glaucoma is an ocular disorder caused due to increased fluid pressure in the optic nerve. It damages the optic nerve subsequently causes loss of vision. The available scanning methods are Heidelberg Retinal Tomography (HRT), Scanning Laser Polarimetry (SLP) and Optical Coherence Tomography (OCT). These methods are expensive and require experienced clinicians to use them. So, there is a need to diagnose glaucoma accurately with low cost. Hence, in this paper, we have presented a new methodology for an automated diagnosis of glaucoma using digital fundus images based on Empirical Wavelet Transform (EWT)...
March 22, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28108378/the-pressure-induced-deformation-response-of-the-human-lamina-cribrosa-analysis-of-regional-variations
#12
Dan E Midgett, Mary E Pease, Joan L Jefferys, Mohak Patel, Christian Franck, Harry A Quigley, Thao D Nguyen
: The objective of this study was to measure the pressure-induced deformation response of the human lamina cribrosa (LC) and analyze for variations with age and anatomical region. The posterior scleral cup of 8 eyes from 6 human donors was mounted onto a custom inflation chamber. A laser-scanning microscope was used for second harmonic generation (SHG), imaging the collagen structure in the posterior volume of the LC at pressures from 5 mmHg to 45 mmHg. The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation (DVC) algorithm for the three dimensional (3D) displacement field...
January 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28106238/choroidal-thickness-and-structural-glaucoma-parameters-in-glaucomatous-preperimetric-glaucomatous-and-healthy-eyes-using-swept-source-oct
#13
Handan Akil, Mayss Al-Sheikh, Khalil Ghasemi Falavarjani, Brian Francis, Vikas Chopra
PURPOSE: To evaluate choroidal thickness (CT) and its relationship with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thickness (GCIPLT) in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source optical coherence tomography (SS-OCT). METHODS: Fifty eyes with primary open-angle glaucoma, 20 eyes with preperimetric glaucoma, and 20 age-matched healthy eyes were enrolled. Three-dimensional wide-field (12 × 9 mm) images were obtained using a SS-OCT instrument...
January 16, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28094584/cytoskeletal-alteration-and-change-of-retinal-nerve-fiber-layer-birefringence-in-hypertensive-retina
#14
Xiang-Run Huang, Robert W Knighton, Ye Z Spector, William J Feuer
PURPOSE: Glaucoma damages the retinal nerve fiber layer (RNFL). Both RNFL thickness and retardance can be used to assess the damage, but birefringence, the ratio of retardance to thickness, is a property of the tissue itself. This study investigated the relationship between axonal cytoskeleton and RNFL birefringence in retinas with hypertensive damage. MATERIALS AND METHODS: High intraocular pressure (IOP) was induced unilaterally in rat eyes. RNFL retardance in isolated retinas was measured...
January 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28088508/relationship-between-central-retinal-vessel-trunk-location-and-visual-field-loss-in-glaucoma
#15
Mengyu Wang, Hui Wang, Louis R Pasquale, Neda Baniasadi, Lucy Q Shen, Peter J Bex, Tobias Elze
PURPOSE: To study the relationship between horizontal central retinal vessel trunk location (CRVTL) on glaucomatous optic discs and sector-specific visual field (VF) loss. DESIGN: Retrospective, cross-sectional study. METHODS: CRVTL of 421 eyes from 421 patients was manually tracked on the horizontal optic disc axis on fundus images. Focal circumpapillary retinal nerve fiber layer thickness (cpRNFLT) measurements were extracted from optical coherence tomography (OCT)...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28073365/neurophthalmological-conditions-mimicking-glaucomatous-optic-neuropathy-analysis-of-the-most-common-causes-of-misdiagnosis
#16
Diego Torres Dias, Michele Ushida, Roberto Battistella, Syril Dorairaj, Tiago Santos Prata
BACKGROUND: To analyze the most common neurophthalmological conditions that may mimic glaucomatous optic neuropathy and to determine which most often lead to misdiagnosis when evaluated by a glaucoma specialist. METHODS: We reviewed the charts of consecutive patients with optic neuropathies caused by neurophthalmological conditions screened in a single Eye Clinic within a period of 24 months. Within these enrolled patients, we selected the eyes whose fundoscopic appearance could resemble glaucoma based in pre-defined criteria (vertical cup-to-disc ratio ≥0...
January 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28068370/visualization-of-radial-peripapillary-capillaries-using-optical-coherence-tomography-angiography-the-effect-of-image-averaging
#17
Shelley Mo, Erika Phillips, Brian D Krawitz, Reena Garg, Sarwat Salim, Lawrence S Geyman, Eleni Efstathiadis, Joseph Carroll, Richard B Rosen, Toco Y P Chui
OBJECTIVES: To assess the effect of image registration and averaging on the visualization and quantification of the radial peripapillary capillary (RPC) network on optical coherence tomography angiography (OCTA). METHODS: Twenty-two healthy controls were imaged with a commercial OCTA system (AngioVue, Optovue, Inc.). Ten 10x10° scans of the optic disc were obtained, and the most superficial layer (50-μm slab extending from the inner limiting membrane) was extracted for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28033298/retinal-and-choroidal-oxygen-saturation-of-the-optic-nerve-head-in-open-angle-glaucoma-subjects-by-multispectral-imaging
#18
Gai-Yun Li, Samer Abdo Al-Wesabi, Hong Zhang
The aim of this study was to determine whether differences exist in oxygen supply to the optic nerve head (ONH) from the retinal and choroidal vascular layers in patients with primary open angle glaucoma (POAG) using multispectral imaging (MSI).This ia an observational, cross-sectional study.Multispectral images were acquired from 38 eyes of 19 patients with POAG, and 42 healthy eyes from 21 matched volunteers with Annidis' RHA multispectral digital ophthalmoscopy. Superficial and deeper oxygen saturation of the optic disc was represented by the mean gray scale values on the retinal and choroidal oxy-deoxy maps, respectively...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#19
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27998461/-research-advances-of-optic-nerve-lamina-cribrosa-structure-and-its-measurement-analysis
#20
T Tian, Y Z Pan
The lamina cribrosa (LC) is believed to be site of injury to retina ganglion cell axons in glaucoma. The ability to visualize this structure helps us increase the understanding of pathophysiological process of glaucoma. At the same time, it is helpful in the early detection and treatment of glaucoma. While for many years the researches on the LC were essentially dependent on histology. With the development of optical coherence tomography (OCT) in recent years, it is possible to image the LC in vivo in both animals and human...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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