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Glaucoma optic nerve imaging

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https://www.readbyqxmd.com/read/29762268/influence-of-removing-the-large-retinal-vessels-related-effect-on-peripapillary-vessel-density-progression-analysis-in-glaucoma
#1
Gábor Holló
PURPOSE: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression. METHODS: Prospective retinal nerve fiber layer thickness (RNFLT) and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits)...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29757019/optical-coherence-tomography-angiography-in-glaucoma-care
#2
Sunee Chansangpetch, Shan C Lin
Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. Optical coherence tomography angiography (OCTA) is the non-invasive in vivo imaging of the vasculature located within the retina and optic nerve head area. The principle of OCTA is to use the variations in OCT signals caused by moving particles as the contrast mechanism for imaging of flow. Several algorithms which aim to maximize the contrast signal and minimize the noise have been developed including the phase-based techniques, intensity-based techniques (e...
May 14, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29750949/automated-beta-zone-parapapillary-area-measurement-to-differentiate-between-healthy-and-glaucoma-eyes
#3
Patricia Isabel C Manalastas, Akram Belghith, Robert N Weinreb, Jost B Jonas, Min Hee Suh, Adeleh Yarmohammadi, Felipe A Medeiros, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill
PURPOSE: To evaluate whether automated assessment of beta-zone parapapillary atrophy (ßPPA) area can differentiate between glaucomatous and healthy eyes of varying axial lengths (AL). DESIGN: Cross-sectional study. METHODS: ßPPA was automatically identified in glaucoma and healthy eyes with enhanced depth imaging optical coherence tomography (OCT) optic nerve head (ONH) radial B-scans. Associations with AL and the presence of glaucoma were assessed...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29740064/tortuous-pore-path-through-the-glaucomatous-lamina-cribrosa
#4
Bo Wang, Katie A Lucy, Joel S Schuman, Ian A Sigal, Richard A Bilonick, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, Zachary Nadler, Hiroshi Ishikawa, Larry Kagemann, James G Fujimoto, Gadi Wollstein
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739027/-uveitic-secondary-glaucoma
#5
Claudia Lommatzsch, Carsten Heinz
An intraocular pressure increase with development of glaucomatous damage is a common complication of uveitis. The prevalence has a wide range depending on various factors such as the underlying uveitis type and the duration of the disease. Pathogenetically, a distinction must be made between a secondary angle closure component and the more frequently occurring open-angle glaucoma. In diagnostics, in addition to the clinical optic nerve head assessment, perimetry and tonometry, the use of imaging examination equipment, such as OCT and HRT, are recommended...
May 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29736326/evaluation-of-a-qualitative-approach-for-detecting-glaucomatous-progression-using-wide-field-optical-coherence-tomography-scans
#6
Zhichao Wu, Denis S D Weng, Rashmi Rajshekhar, Abinaya Thenappan, Robert Ritch, Donald C Hood
Purpose: To determine the effectiveness of detecting glaucomatous progression by a qualitative evaluation of wide-field (12 × 9 mm) scans on optical coherence tomography imaging. This method was compared to a conventional quantitative analysis of the global circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Methods: A total of 409 eyes with a clinical diagnosis of glaucoma or suspected glaucoma for which two wide-field scans were obtained at least 1 year apart ( n = 125) and within one session ( n = 284) were included to determine the sensitivity of detecting progression at 95% specificity...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29706620/the-effect-of-trabeculectomy-surgery-on-the-central-visual-field-in-patients-with-glaucoma-using-microperimetry-and-optical-coherence-tomography
#7
Gokulan Ratnarajan, Jasleen K Jolly, Imran H Yusuf, John F Salmon
PURPOSE: To determine the functional and structural effects of trabeculectomy surgery on patients with advanced glaucoma and central visual field defects in the early post-operative period. METHODS: Thirty consecutive adult subjects with advanced glaucoma requiring trabeculectomy surgery and an established visual field defect within 10° of fixation underwent microperimetry (MAIA MP-1, CenterVue, Padova, Italy) and optic disc optical coherence tomography (OCT) imaging (Spectralis, Heidelberg Engineering, Germany) pre-operatively, and 1 month and 3 months following trabeculectomy surgery...
April 30, 2018: Eye
https://www.readbyqxmd.com/read/29706619/microperimetry-and-optical-coherence-tomography-imaging-in-the-fellow-eye-of-patients-with-unilateral-focal-ischaemic-glaucoma
#8
Imran H Yusuf, Jasleen K Jolly, Gokulan Ratnarajan, John F Salmon
PURPOSE: To determine whether microperimetry or optical coherence tomography (OCT) imaging can detect early disease in the fellow eye of patients with unilateral focal ischaemic glaucoma. METHODS: Thirty-seven consecutive adult patients with unilateral focal ischaemic glaucoma with a unilateral split-fixation visual field defect on standard automated perimetry (SAP) with normal SAP in the fellow eye were selected. All patients underwent microperimetry (MAIA, CenterVue, Italy) of the central 10 degrees and OCT imaging (Spectralis, Heidelberg Engineering, Germany) of the retinal nerve fibre layer of both eyes...
April 30, 2018: Eye
https://www.readbyqxmd.com/read/29671151/an-atypical-case-of-neurosarcoidosis-presenting-with-neovascular-glaucoma
#9
REVIEW
Melissa Vereecken, Karolien Hollanders, Deborah De Bruyn, Virginie Ninclaus, Julie De Zaeytijd, Ilse De Schryver
BACKGROUND: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative. FINDINGS: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Slit lamp examination revealed anterior chamber cells, iris, and angle neovascularization...
April 18, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29651339/comparison-of-optical-coherence-tomography-angiography-and-laser-speckle-flowgraphy-for-the-diagnosis-of-normal-tension-glaucoma
#10
Asuka Takeyama, Kyoko Ishida, Ayako Anraku, Masahiro Ishida, Goji Tomita
Purpose: To compare optical coherence tomography angiography (OCT-A) and laser speckle flowgraphy (LSFG) for the diagnosis of normal-tension glaucoma (NTG). Methods: Twenty-eight eyes of 28 patients with NTG and 25 eyes of 25 normal subjects matched for age, refractive errors, systemic blood pressure, and central corneal thickness were evaluated. OCT-A was used to measure whole image vessel density, inside disc vessel density, and peripapillary vessel density; using LSFG, mean blur rate (MBR) inside the whole optic nerve head (ONH) area (MBRA ), and MBR of the vessel area (MBRV ) and tissue area (MBRT ) inside the ONH, were determined...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29621390/association-of-myopia-with-peripapillary-perfused-capillary-density-in-patients-with-glaucoma-an-optical-coherence-tomography-angiography-study
#11
Yanin Suwan, Masoud Aghsaei Fard, Lawrence S Geyman, Apichat Tantraworasin, Toco Y Chui, Richard B Rosen, Robert Ritch
Importance: This study used optical coherence tomographic angiography to assess for impaired blood flow in myopic eyes with or without open-angle glaucoma. Objective: To compare the peripapillary perfused capillary density (PCD) between eyes with and without glaucoma. Design, Setting, and Participants: In this cross-sectional study at a tertiary glaucoma referral practice, we recruited patients with myopic eyes of spherical equivalent of more than -3...
April 5, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29621263/wide-scan-imaging-with-swept-source-optical-coherent-tomography-for-glaucoma-diagnosis
#12
Eun Hee Hong, Yong Un Shin, Min Ho Kang, Heeyoon Cho, Mincheol Seong
PURPOSE: To determine glaucoma-discriminating abilities of macular and circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurements of wide scan (12X9mm) using swept-source optical coherence tomography (SS-OCT) compared to measurements of standard macula and disc scans (6 X 6 mm). METHODS: This retrospective chart review study included 60 glaucomatous and 62 healthy eyes of total 122 subjects who visited a glaucoma clinic and were examined with wide, standard macula, and standard disc scans of SS-OCT (DRI-OCT-1 Atlantis; Topcon Inc...
2018: PloS One
https://www.readbyqxmd.com/read/29613982/association-between-the-deep-layer-microvasculature-dropout-and-the-visual-field-damage-in-glaucoma
#13
Min Hee Suh, Jun Woo Park, Hae Rang Kim
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4)...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29602236/evaluating-glaucomatous-abnormality-in-peripapillary-optical-coherence-tomography-enface-visualisation-of-the-retinal-nerve-fibre-layer-reflectance
#14
Bright S Ashimatey, Brett J King, Stephen A Burns, William H Swanson
PURPOSE: Optical coherence tomography (OCT) enface visualisation of the retinal nerve fibre layer (RNFL) reflectance has been found to have some advantages over retinal thickness measures. However, it is not yet clear how abnormalities on enface images relate to findings of abnormalities from other clinical measures such as the circumpapillary retinal nerve fibre layer thickness (cRNFLT). We developed a technique to analyse the RNFL reflectance on the OCT enface images, and to investigate its relation with the cRNFLT...
March 30, 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29582808/simplifying-target-intraocular-pressure-for-different-stages-of-primary-open-angle-glaucoma-and-primary-angle-closure-glaucoma
#15
REVIEW
Ramanjit Sihota, Dewang Angmo, Deepa Ramaswamy, Tanuj Dada
Lowering of intraocular pressure is currently the only therapeutic measure for Glaucoma management. Many longterm, randomized trials have shown the efficacy of lowering IOP, either by a percentage of baseline, or to a specified level. This has lead to the concept of 'Target" IOP, a range of IOP on therapy, that would stabilize the Glaucoma/prevent further visual field loss, without significantly affecting a patient's quality of life. A clinical staging of Glaucoma by optic nerve head evaluation and perimetric parameters, allows a patient's eye to be categorized as having - mild, moderate or severe Glaucomatous damage...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29576929/customizing-perimetric-locations-based-on-en-face-images-of-retinal-nerve-fiber-bundles-with-glaucomatous-damage
#16
Muhammed S Alluwimi, William H Swanson, Victor E Malinovsky, Brett J King
Purpose: Prior studies suggested the use of customized perimetric locations in glaucoma; these studies were limited by imaging only the superficial depths of the retinal nerve fiber layer (RNFL) and by prolonged perimetric testing. We aimed to develop a rapid perimetric test guided by high-resolution images of RNFL bundles. Methods: We recruited 10 patients with glaucoma, ages 56 to 80 years, median 68 years, and 10 controls, ages 55 to 77 years, median 68 years...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29575745/evaluation-of-two-dimensional-bruch-s-membrane-opening-minimum-rim-area-for-glaucoma-diagnostics-in-a-large-patient-cohort
#17
Philip Enders, Werner Adler, David Kiessling, Vincent Weber, Friederike Schaub, Manuel M Hermann, Thomas Dietlein, Claus Cursiefen, Ludwig M Heindl
PURPOSE: To characterize the two-dimensional parameter Bruch's membrane opening minimum rim area (BMO-MRA) in spectral domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO-MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. METHODS: Case-control, cross-sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD-OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination...
March 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29575676/ocular-microcirculation-measurement-with-laser-speckle-flowgraphy-and-optical-coherence-tomography-angiography-in-glaucoma
#18
Naoki Kiyota, Hiroshi Kunikata, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
PURPOSE: To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA). METHODS: We retrospectively studied 82 eyes of 82 open-angle glaucoma (OAG) patients who underwent same-day LSFG and OCTA examinations, with 20 eyes of 20 healthy subjects as controls. In OCTA images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1...
March 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29575582/imaging-the-deep-optic-nerve-developing-mechanistic-biomarkers-for-glaucoma
#19
EDITORIAL
Christopher A Girkin
No abstract text is available yet for this article.
March 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29570721/structural-and-functional-analyses-of-the-optic-nerve-and-lateral-geniculate-nucleus-in-glaucoma
#20
Rafael Lacerda Furlanetto, Sergio Henrique Teixeira, Carolina Pelegrini Barbosa Gracitelli, Claudio Luiz Lottenberg, Fabiano Emori, Michel Michelan, Edson Amaro, Augusto Paranhos
PURPOSE: To analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage. METHODS: In this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluation; and 3T MRI...
2018: PloS One
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