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https://www.readbyqxmd.com/read/29327812/hyper-acetylation-contributes-to-the-sensitivity-of-chemo-resistant-prostate-cancer-cells-to-histone-deacetylase-inhibitor-trichostatin-a
#1
Qingqing Xu, Xiaofei Liu, Shiqin Zhu, Xuelei Hu, Huanmin Niu, Xiulei Zhang, Deyu Zhu, Effat Un Nesa, Keli Tian, Huiqing Yuan
Therapeutic agents are urgently needed for treating metastatic castration-refractory prostate cancer (mCRPC) that is unresponsive to androgen deprivation and chemotherapy. Our screening assays demonstrated that chemotherapy-resistant prostate cancer (PCa) cells are more sensitive to HDAC inhibitors than paired sensitive PCa cells, as demonstrated by cell proliferation and apoptosis in vitro and in vivo. Kinetic study revealed that TSA-induced apoptosis was significantly dependent on enhanced transcription and protein synthesis in an early stage, which subsequently caused ER stress and apoptosis...
January 12, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29325728/myo-inositol-lowers-the-risk-of-developing-gestational-diabetic-mellitus-in-pregnancies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-with-trial-sequential-analysis
#2
REVIEW
Xianshan Guo, Shizhe Guo, Zhiyi Miao, Zhen Li, Hongya Zhang
AIMS: to explore the potential benefit of myo-inositol on pregnant women with high risk of developing gestational diabetes mellitus (GDM). METHODS: Pubmed, Embase, and Cochrane library were systematically searched for randomized controlled trials (RCTs) comparing myo-inositol with placebo for pregnant women with risk factors of GDM. Primary outcome were the incidence of GDM and birth weight. Secondary outcomes included fasting, 1h, and 2h oral glucose tolerance test (OGTT), and complications...
July 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29315514/cytotoxic-edema-at-onset-in-west-syndrome-of-unknown-etiology-a-longitudinal-diffusion-tensor-imaging-study
#3
Chikako Ogawa, Hiroyuki Kidokoro, Tatsuya Fukasawa, Hiroyuki Yamamoto, Naoko Ishihara, Yuji Ito, Yoko Sakaguchi, Yu Okai, Atsuko Ohno, Tomohiko Nakata, Yoshiteru Azuma, Ayako Hattori, Tetsuo Kubota, Takeshi Tsuji, Akihiro Hirakawa, Hisashi Kawai, Jun Natsume
OBJECTIVE: To clarify longitudinal changes in white matter microstructures from the onset of disease in patients with West syndrome (WS) of unknown etiology. METHODS: Diffusion tensor imaging (DTI) was prospectively performed at onset and at 12 and 24 months old in 17 children with WS of unknown etiology. DTI was analyzed using tract-based spatial statistics (TBSS) and tract-specific analysis (TSA) of 13 fiber tracts, and fractional anisotropy (FA) and mean diffusivity (MD) were compared with those of 42 age-matched controls...
January 8, 2018: Epilepsia
https://www.readbyqxmd.com/read/29304767/mlh1-93%C3%A2-g-a-polymorphism-is-associated-with-mlh1-promoter-methylation-and-protein-loss-in-dysplastic-sessile-serrated-adenomas-with-brafv600e-mutation
#4
Lochlan J Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall
BACKGROUND: Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSADs and BRAF mutant traditional serrated adenomas (TSA) develop into microsatellite stable cancers with a poor prognosis. The reason for this dichotomy is unknown. In this study, we assessed the genotypic frequency of the MLH1-93 polymorphism rs1800734 in SSADs and TSAs to determine if the uncommon variant A allele predisposes to MLH1 promoter hypermethylation...
January 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29303911/histone-deacetylase-inhibition-restores-expression-of-hypoxia-inducible-protein-ndrg1-in-pancreatic-cancer
#5
Céline Tiffon
OBJECTIVES: N-myc downstream-regulated gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. METHODS: PANC-1 (poorly differentiated) and Capan-1 (moderately to well differentiated) cells were treated with TSA...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29301535/inhibition-of-histone-deacetylase-activity-rescues-inflammatory-cystic-fibrosis-lung-disease-by-modulating-innate-and-adaptive-immune-responses
#6
Manish Bodas, Steven Mazur, Taehong Min, Neeraj Vij
BACKGROUND: Chronic lung disease resulting from dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and NFκB-mediated neutrophilic-inflammation forms the basis of CF-related mortality. Here we aimed to evaluate if HDAC inhibition controls Pseudomonas-aeruginosa-lipopolysaccharide (Pa-LPS) induced airway inflammation and CF-lung disease. METHODS: For in vitro experiments, HEK293-cells were transfected with IL-8 or NFκB-firefly luciferase, and SV40-renilla- luciferase reporter constructs or ΔF508-CFTR-pCEP, followed by treatment with suberoylanilide hydroxamic acid (SAHA), Trichostatin-A (TSA) and/or TNFα...
January 4, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29301062/regulatory-roles-of-histone-deacetylases-1-and-2-in-pb-induced-neurotoxicity
#7
Yulan Wu, Yi Xu, Xiyao Huang, Danlei Ye, Miaomiao Han, Hui-Li Wang
Lead (Pb) prevails among the environmental hazards against human health. Although increasing evidence highlights the epigenetic roles underlying the Pb-induced neurotoxicity, the exact mechanisms concerning histone acetylation and its causative agents are still at its infancy. In the present study, the roles of histone deacetylases 1 and 2 (HDAC1/2), as well as histone H3 Lys9 acetylation (Ac-H3K9), in Pb-induced neurotoxicity were investigated. Pb was administered to PC12 cells at 10 μM for 24 hours. And Sprague- Dawley rats were chronically exposed to Pb through drinking water containing 250 ppm Pb for 2 months...
January 2, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29299846/larkinella-roseus-sp-nov-a-species-of-the-family-cytophagaceae-isolated-from-beach-soil
#8
Jae-Bong Lee, Sumin Hong, Seung-Yeol Lee, Su-Jin Park, Kyeung Il Park, Seok-Gwan Choi, Myung Kyum Kim, Leonid N Ten, Hee-Young Jung
The taxonomic position of bacterial strain, designated 15J16-1T3AT, recovered from a soil sample was established using a polyphasic approach. Phylogenic analysis based on the 16S rRNA gene sequence showed that strain 15J16-1T3AT belonged to the family Cytophagaceae, phylum Bacteroidetes, and was most closely related to 'Larkinella harenae' 15J9-9 (95.9% similarity), Larkinella ripae 15J11-11T (95.6%), Larkinella bovis M2TB15T (94.7%), Larkinella arboricola Z0532T (93.9%), and Larkinella insperata LMG 22510T (93...
January 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29299363/does-histology-really-influence-gastric-cancer-prognosis
#9
Carrie Luu, Ram Thapa, Katherine Woo, Domenico Coppola, Khaldoun Almhanna, Jose M Pimiento, Dung-Tsa Chen, Daissy Dominguez Marquez, Pamela J Hodul
Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival. Methods: The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signet-ring cell features (n=57), and LP (n=40)...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29291095/the-interaction-of-fatigue-cracks-with-a-residual-stress-field-using-thermoelastic-stress-analysis-and-synchrotron-x-ray-diffraction-experiments
#10
Khurram Amjad, David Asquith, Eann A Patterson, Christopher M Sebastian, Wei-Chung Wang
This article presents an experimental study on the fatigue behaviour of cracks emanating from cold-expanded holes utilizing thermoelastic stress analysis (TSA) and synchrotron X-ray diffraction (SXRD) techniques with the aim of resolving the long-standing ambiguity in the literature regarding potential relaxation, or modification, of beneficial compressive residual stresses as a result of fatigue crack propagation. The crack growth rates are found to be substantially lower as the crack tip moved through the residual stress zone induced by cold expansion...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29288321/rassf1a-promoter-methylation-was-associated-with-the-development-progression-and-metastasis-of-cervical-carcinoma-a-meta-analysis-with-trial-sequential-analysis
#11
Fei Zheng, Huimin Yu
BACKGROUND: RASSF1A promoter methylation has been reported in cervical cancer. However, clinical effect of RASSF1A promoter methylation in cervical cancer remains unclear. This meta-analysis was conducted to assess the correlation between RASSF1A promoter methylation and cervical cancer and the association of RASSF1A promoter methylation with clinicopathological features. METHODS: Electronic databases were searched to identify eligible publications. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated...
December 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29286617/genistein-and-trichostatin-a-induction-of-estrogen-receptor-alpha-gene-expression-apoptosis-and-cell-growth-inhibition-in-hepatocellular-carcinoma-hepg-2-cells
#12
Masumeh Sanaei, Fraidoon Kavoosi, Habibeh Salehi
Epigenetic changes such as DNA methylation and histone acetylation play important roles in determining gene expression. Hypermethylation of CpG islands of the promoter region of tumor suppressor genes can greatly influence carcinogenesis through transcriptional silencing. Acetylation of lysine in histone tails causes relaxation of chromatin, which facilitates gene transcription, while deacetylation is associated with condensed chromatin resulting in gene silencing. DNA demethylating agents such as genistein (GE) and histone deacetylase inhibitors (HDACIs) such as trichostatin A (TSA) may strongly reactivate silenced genes and exposure to these two agents in combination is reported to enhance estrogen receptor alpha (ERα) reactivation and induction of apoptosis...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29279589/dna-vaccination-with-a-plasmid-encoding-lack-tsa-fusion-against-leishmania-major-infection-in-balb-c-mice
#13
N Maspi, F Ghaffarifar, Z Sharifi, A Dalimi, S Z Khademi
Vaccination would be the most important strategy for the prevention and elimination of leishmaniasis. The aim of the present study was to compare the immune responses induced following DNA vaccination with LACK (Leishmania analogue of the receptor kinase C), TSA (Thiol-specific-antioxidant) genes alone or LACK-TSA fusion against cutaneous leishmaniasis (CL). Cellular and humoral immune responses were evaluated before and after challenge with Leishmania major (L. major). In addition, the mean lesion size was also measured from 3th week post-infection...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29277014/effects-of-trichostatin-a-on-pig-scnt-blastocyst-formation-rate-and-cell-number-a-meta-analysis
#14
REVIEW
Zhenhua Guo, Lei Lv, Di Liu, Bo Fu
Although somatic cell nuclear transfer (SCNT) can be used to create transgenic pigs for human xenotransplantation, low efficiency limits its use. Trichostatin A (TSA) promotes SCNT embryo development, but whether TSA modifies SCNT blastocyst numbers is unclear. Thus, there is an urgent need to understand whether TSA modifies the rate and number of embryos that grow from oocytes to blastocysts in culture and what types of cell signaling pathways may be involved. Thus, we identified 63 reports, of which 13 are included in this meta-analysis...
December 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29274516/highly-efficient-magnetic-chicken-bone-biochar-for-removal-of-tetracycline-and-fluorescent-dye-from-wastewater-two-stage-adsorber-analysis
#15
Akeem Adeyemi Oladipo, Ayodeji Olugbenga Ifebajo
Magnetic chicken bone biochar (MCB) was fabricated and characterised. The specific surface area, magnetisation value and pHpzc of the MCB were found to be 328 m2 g-1, 64.7 emu/g and 8.3 respectively. The adsorptive performance of MCB for rhodamine B dye (RB) and tetracycline (TC) removal in a single and two-stage stirred adsorber (TSA) was evaluated. The TSA reduced the pressure drops, mass transfer resistances, and fouling of the adsorbent. 63.0 g MCB is required to remove 75% of RB and TC in a single-stage system within 12 h...
December 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29274335/cd36-mediates-lipid-accumulation-in-pancreatic-beta-cells-under-the-duress-of-glucolipotoxic-conditions-novel-roles-of-lysine-deacetylases
#16
Sabbir Khan, Anjaneyulu Kowluru
The cluster of differentiation 36 (CD36) is implicated in the intake of long-chain fatty acids and fat storage in various cell types including the pancreatic beta cell, thus contributing to the pathogenesis of metabolic stress and diabetes. Recent evidence indicates that CD36 undergoes post-translational modifications such as acetylation-deacetylation. However, putative roles of such modifications in its functional activation and onset of beta cell dysregulation under the duress of glucolipotoxicity (GLT) remain largely unknown...
December 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29273386/total-shoulder-arthroplasty-with-minimum-5-year-follow-up-does-the-presence-of-subchondral-cysts-in-the-glenoid-increase-risk-of-failure
#17
Gregory Tanner, Peter Simon, Thomas Sellers, Kaitlyn N Christmas, Randall J Otto, Derek J Cuff, Adham Abdelfattah, Mark A Mighell, Mark A Frankle
BACKGROUND: This study evaluated the effect of cystic changes in the glenoid on postoperative outcomes and implant survival after total shoulder arthroplasty (TSA). MATERIALS AND METHODS: From 2004 to 2012, 75 patients underwent TSA for primary osteoarthritis with minimum 5-year follow-up. Preoperative 3-dimensional models based on computed tomography imaging were created for all patients. A qualitative evaluation of cystic osteoarthritis was performed through survey grading by 3 fellowship-trained shoulder surgeons...
December 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29248540/sodium-butyrate-triggers-a-functional-elongation-of-microglial-process-via-akt-small-rhogtpase-activation-and-hdacs-inhibition
#18
Peng Wang, Yaru Zhang, Yu Gong, Rongrong Yang, Zhuo Chen, Wenfeng Hu, Yue Wu, Minhui Gao, Xing Xu, Yibin Qin, Chao Huang
Microglia, a type of immune cell in the brain, are in a ramified status with branched processes in normal conditions. Upon pathological stimulation, microglia retract their processes and become activated. Searching methods to make the activated microglia return to ramified status would help cope with injuries induced by neuroinflammation. Here, we investigated the influence of sodium butyrate (SB), a sodium salt form of butyrate produced by fermentation of dietary fibers in the gut on microglial process. Results showed that SB induced reversible elongations of microglial process in both normal and inflammatory conditions, and these elongations were accompanied with significant changes in markers reflecting the pro-inflammatory and anti-inflammatory status of microglia...
December 14, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29247237/transcription-of-a-b-chromosome-cap-g-pseudogene-does-not-influence-normal-condensin-complex-genes-in-a-grasshopper
#19
Beatriz Navarro-Domínguez, Francisco J Ruiz-Ruano, Juan Pedro M Camacho, Josefa Cabrero, María Dolores López-León
Parasitic B chromosomes invade and persist in natural populations through several mechanisms for transmission advantage (drive). They may contain gene-derived sequences which, in some cases, are actively transcribed. A further interesting question is whether B-derived transcripts become functional products. In the grasshopper Eyprepocnemis plorans, one of the gene-derived sequences located on the B chromosome shows homology with the gene coding for the CAP-G subunit of condensin I. We show here, by means of fluorescent in situ hybridization coupled with tyramide signal amplification (FISH-TSA), that this gene is located in the distal region of the B24 chromosome variant...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246481/shoulder-patient-specific-guide-first-experience-in-10-patients-indicates-room-for-improvement
#20
J Berhouet, M Rol, C Spiry, M Slimane, C Chevalier, L Favard
BACKGROUND: Implantation of the glenoid component of a total shoulder prosthesis can be facilitated by using a patient-specific guide (PSG) designed to ensure replication of the preoperatively planned position. The objective of this study was to assess the reliability and accuracy of a PSG in replicating the planned glenoid component position during total shoulder arthroplasty (TSA). HYPOTHESIS: Additional criteria should be used for 3D preoperative planning and PSG design to further improve the accuracy of glenoid component positioning...
December 12, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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