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https://www.readbyqxmd.com/read/28330420/arthroplasty-treatment-of-proximal-humerus-fractures-14-year-trends-in-the-united-states
#1
William W Schairer, Benedict U Nwachukwu, Stephen Lyman, Lawrence V Gulotta
OBJECTIVES: Proximal humerus fractures are a common injury in the elderly population that can usually be managed non-operatively. However, arthroplasty has become increasingly utilized for complex fractures and poor bone quality. We evaluated national trends in treatment, specifically looking at the adoption of reverse total shoulder arthroplasty. METHODS: The incidence of proximal humerus fractures was calculated from the Nationwide Emergency Department Database (NEDD) from 2006-2012...
March 22, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28329026/the-effect-of-early-versus-late-initiation-of-renal-replacement-therapy-in-patients-with-acute-kidney-injury-a-meta-analysis-with-trial-sequential-analysis-of-randomized-controlled-trials
#2
Yan-Mei Feng, Yuan Yang, Xiao-Li Han, Fan Zhang, Dong Wan, Rui Guo
BACKGROUND: The optimal timing for initiating renal replacement therapy (RRT) in patients with acute kidney injury (AKI) remains controversial. METHODS: We conducted a meta-analysis with trial sequential analysis (TSA) of randomized controlled trials (RCTs) using PUBMED, Cochrane Library databases, and Web of Science (from January 1, 1985, to August 21, 2016). Adult patients with AKI who received RRT with different timing were included. The primary outcome was mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28319426/high-satisfaction-and-return-to-sports-after-total-shoulder-arthroplasty-in-patients-aged-55-years-and-younger
#3
Grant H Garcia, Joseph N Liu, Alec Sinatro, Hao-Hua Wu, Joshua S Dines, Russell F Warren, David M Dines, Lawrence V Gulotta
BACKGROUND: Young, active candidates for total shoulder arthroplasty (TSA) are a unique group of patients. Not only do they demand longevity and improved function, but they also desire a return to physical activities. PURPOSE: To determine the rate of return to sports in patients aged ≤55 years undergoing TSA. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This was a retrospective review of consecutive patients who underwent anatomic TSA at a single institution...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28306192/histone-deacetylase-activity-mediates-acquired-resistance-towards-structurally-diverse-hsp90-inhibitors
#4
Ryan C Chai, Jessica L Vieusseux, Benjamin J Lang, Chau H Nguyen, Michelle M Kouspou, Kara L Britt, John T Price
Heat Shock Protein 90 (HSP90) regulates multiple signaling pathways critical for tumor growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date. One potential reason for this may the presence of de novo or acquired resistance within the tumors. To investigate mechanisms of resistance, we generated resistant cell lines through gradual dose escalation of the HSP90 inhibitor 17-AAG...
March 17, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28303944/relationships-between-strength-and-endurance-parameters-and-air-depletion-rates-in-professional-firefighters
#5
Stephanie Windisch, Wolfgang Seiberl, Ansgar Schwirtz, Daniel Hahn
The aim of this study was to quantify the physical demands of a simulated firefighting circuit and to establish the relationship between job performance and endurance and strength fitness measurements. On four separate days 41 professional firefighters (39 ± 9 yr, 179.6 ± 2.3 cm, 84.4 ± 9.2 kg, BMI 26.1 ± 2.8 kg/m(2)) performed treadmill testing, fitness testing (strength, balance and flexibility) and a simulated firefighting exercise. The firefighting exercise included ladder climbing (20 m), treadmill walking (200 m), pulling a wire rope hoist (15 times) and crawling an orientation section (50 m)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302148/thermal-quantitative-sensory-testing-in-healthy-dutch-children-and-adolescents-standardized-test-paradigm-and-dutch-reference-values
#6
Gerbrich E van den Bosch, Monique van Dijk, Dick Tibboel, Abraham J Valkenburg
BACKGROUND: Quantitative sensory testing (QST) is often used to measure children's and adults' detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often applied to determine thermal detection and pain thresholds. As comparisons between studies are hampered by the different testing protocols used, we aimed to present a standard protocol and reference values for thermal detection- and pain thresholds in children. METHODS: Our standard testing protocol includes reaction time dependent and independent tests and takes about 14-18 min to complete...
March 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28295534/mucin-rich-variant-of-traditional-serrated-adenoma-mrtsa-a-distinct-morphological-variant
#7
Sangeetha N Kalimuthu, Stefano Serra, Sara Hafezi-Bakhtiari, Richard Colling, Lai Mun Wang, Runjan Chetty
Traditional serrated adenomas (TSAs) account for 5% of serrated polyps, have villiform architecture, eosinophilic cells with a brush border and indented, flat-topped luminal serrations. However, some are composed of mucin-filled goblet cells (GC): a mucin-rich variant (MrTSA). The aim of this study was to determine if this variant has unique features compared to classic TSA (cTSA). 156 TSAs were retrieved from 2010-2016. Patient demographics, site of polyps, and 16 microscopic variables, were evaluated. TSAs containing 50% or more GCs were classified as MrTSAs...
March 13, 2017: Histopathology
https://www.readbyqxmd.com/read/28295004/-serrated-adenomas-of-the-colon-clinical-morphological-and-molecular-genetic-characteristics
#8
L M Mikhaleva, R A Komleva, A E Biryukov, N K Shakhpazyan
AIM: to investigate the clinical, morphological, and molecular genetic characteristics of serrated adenomas of the colon. MATERIAL AND METHODS: The study included 82 colon adenomas from 63 patients aged 29 to 81 years, who underwent colonoscopy with biopsy or polypectomy. The mean age of men was 63.3 years; that of women was 56.8 years. Comprehensive clinical, morphological, immunohistochemical, and molecular genetic examinations were made. RESULTS: The histological examination showed that sessile serrated adenomas (SSA) of the colon were most common (46...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28288837/can-cranberries-contribute-to-reduce-the-incidence-of-urinary-tract-infections-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-clinical-trials
#9
Ângelo Luís, Fernanda Domingues, Luísa Pereira
PURPOSE: To clarify the association between cranberries intake and the prevention of urinary tract infections (UTIs). METHODS: It was performed a systematic review, complied with the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statement, followed by a meta-analysis and trial sequential analysis (TSA) of clinical trials. RESULTS: The results clearly show the potential use of cranberries in a clinical condition of UTI...
March 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28287709/the-michaelis-complex-of-arginine-kinase-samples-the-transition-state-at-a-frequency-that-matches-the-catalytic-rate
#10
Yu Peng, Alexandar L Hansen, Lei Bruschweiler-Li, Omar Davulcu, Jack J Skalicky, Michael S Chapman, Rafael Bruschweiler
Arginine kinase (AK), which is a member of the phosphagen kinase family, serves as a model system for studying the structural and dynamic determinants of biomolecular enzyme catalysis of all major states involved of the enzymatic cycle. These states are the apo state (substrate free), the Michaelis complex analog AK:arginine:Mg.AMPPNP (MCA), a product complex analog AK:pAIE:Mg.ADP (PCA), and the transition state analog AK:Arg:Mg.ADP:NO3- (TSA). The conformational dynamics of these states have been studied by NMR relaxation dispersion measurements of the methyl groups of the Ile, Leu, and Val residues at two static magnetic fields...
March 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28281974/silencing-of-atp4b-of-atpase-h-k-transporting-beta-subunit-by-intragenic-epigenetic-alteration-in-human-gastric-cancer-cells
#11
Shuye Lin, Bonan Lin, Xiaoyue Wang, Yuanming Pan, Qing Xu, Jin-Shen He, Wanghua Gong, Rui Xing, Yuqi He, Lihua Guo, Youyong Lu, Ji Ming Wang, Jiaqiang Huang
The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the β subunit of the gastric H+, K+-ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site...
March 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28277895/serrated-polyps-a-concealed-but-prevalent-precursor-of-colorectal-cancer
#12
Henrik Thorlacius, Yoji Takeuchi, Takashi Kanesaka, Otto Ljungberg, Noriya Uedo, Ervin Toth
Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1-2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer...
March 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28274037/antimicrobial-effects-of-garcinia-mangostana-on-cariogenic-microorganisms
#13
Sunitha Janardhanan, Jaideep Mahendra, A S Smiline Girija, Little Mahendra, Vijayashree Priyadharsini
INTRODUCTION: Garcinia mangostana commonly called as Mangosteen fruit has been used as an antibacterial agent since age old times. The mangosteen pericarp has proven to have antibacterial effect, but the effect of the same on cariogenic organisms has not been explored. The present study was an attempt to gain a better understanding of the antibacterial effect of mangosteen pericarp on the cariogenic bacteria, to unravel the therapeutic potential for the same. AIM: The aim of the study was to assess the antibacterial efficacy of the crude chloroform extract of mangosteen pericarp against cariogenic bacteria...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28263427/body-mass-index-and-distribution-of-body-fat-can-influence-sensory-detection-and-pain-sensitivity
#14
O A Tashani, R Astita, D Sharp, M I Johnson
BACKGROUND: The aim of this study was to investigate the influence of body fat percentage and its distribution on sensory detection and pain sensitivity responses to experimentally induced noxious stimuli in otherwise pain-free individuals. METHODS: Seventy-two participants were divided into three equal groups according to their body mass index (BMI: normal, overweight and obese). Percentage body fat was estimated using a four-site skinfold method. Measurements of cold pressor pain threshold, tolerance and intensity; contact thermal sensory detection and heat pain threshold and tolerance (TSA-II - NeuroSensory Analyzer, Medoc); and blunt pressure pain threshold (algometer, Somedic SenseLab AB) were taken at the waist and thenar eminence...
March 6, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28256437/the-main-cause-of-instability-after-unconstrained-shoulder-prosthesis-is-soft-tissue-deficiency
#15
Jean Kany, Jijo Jose, Denis Katz, Jean David Werthel, Padmanaban Sekaran, Rajkumar S Amaravathi, Philippe Valenti
BACKGROUND: Instability is one of the major causes of failures in unconstrained anatomic total shoulder arthroplasty (TSA). This study reviewed the instabilities that may occur in an anatomic shoulder platform system to identify its potential predictors. We hypothesized that soft tissue deficiency was the main cause of instability and that the best treatment option would be conversion to a reverse shoulder arthroplasty (RSA). MATERIALS AND METHODS: Between 2003 and 2013, we reviewed 27 patients who experienced postoperative instability, and the overall incidence was 5...
February 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28250130/pathways-of-prion-spread-during-early-chronic-wasting-disease-in-deer
#16
Clare E Hoover, Kristen A Davenport, Davin M Henderson, Nathaniel D Denkers, Candace K Mathiason, Claudio Soto, Mark D Zabel, Edward A Hoover
Among prion infections, two scenarios of prion spread are generally observed: (a) early lymphoid tissue replication or (b) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studies of early CWD pathogenesis have implicated pharyngeal lymphoid tissue as the earliest sites of prion accumulation. However, knowledge of chronological events in prion spread during early infection remains incomplete...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28241043/use-of-eschar-swabbing-for-the-molecular-diagnosis-and-genotyping-of-orientia-tsutsugamushi-causing-scrub-typhus-in-quang-nam-province-vietnam
#17
Nhiem Le Viet, Maureen Laroche, Hoa L Thi Pham, Nho L Viet, Oleg Mediannikov, Didier Raoult, Philippe Parola
BACKGROUND: Scrub typhus is a rickettsiosis which is caused by Orientia tsutsugamushi and occurs throughout the Asia-Pacific region. Molecular diagnosis of rickettsioses using eschar swabs has recently emerged, and may be very useful for the diagnosis of these diseases in tropical settings. METHODOLOGY/PRINCIPAL FINDINGS: Quantitative polymerase chain reaction (qPCR) was used to detect O. tsutsugamushi DNA in whole blood and eschar swab specimens of 67 patients who were clinically suspected of scrub typhus in Quang Nam province, Vietnam...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28240208/-autoimmune-disease-predisposition-aire-%C3%A2-%C3%A2-protects%C3%A2-%C3%A2-men
#18
Nadine Dragin, Rozen Le Panse, Sonia Berrih-Aknin
Autoimmune diseases are a group of about 80 different diseases affecting 5-8% of the population. They are due to a deregulation of the immune system that attacks specific molecules and/or cells in the body. The thymus is the school of T cells that must be able to react to foreign molecules penetrating into the body. This education process is mediated by interactions between T cells and thymic epithelial cells (TEC) that express specific proteins of the peripheral tissues (TSA, "tissue-specific antigen"). This complex mechanism is called central tolerance...
February 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28239736/ferrocene-diketopyrrolopyrrole-based-small-molecule-donors-for-bulk-heterojunction-solar-cells
#19
Yuvraj Patil, Rajneesh Misra, Manish Kumar Singh, Ganesh D Sharma
A symmetrical D-π-A-π-D type small molecule consisting of thiophene flanked diketopyrrolopyrrole (DPP) as a core and an end capping ferrocene donor linked by an ethynyl bridge, denoted as Fc-DPP-Fc, was synthesized and its optical, thermal and electrochemical properties were investigated in order to explore its potential applicability as a donor for solution processed bulk heterojunction solar cells. The photophysical and electrochemical properties of this small molecule showed strong charge transfer interaction between the ferrocene donor and the DPP acceptor, and it is found to be suitable as a small molecule donor along with PC71BM as an electron acceptor for solution processed bulk heterojunction organic solar cells (OSCs)...
February 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28231440/effects-of-acupressure-on-chemotherapy-induced-nausea-and-vomiting-a-systematic-review-with-meta-analyses-and-trial-sequential-analysis-of-randomized-controlled-trials
#20
REVIEW
Jing Miao, Xinyou Liu, Chaojun Wu, Hui Kong, Weiping Xie, Kouying Liu
BACKGROUND: Acupressure has been used as an effective way in treating with stomach upset. However the efficacy of acupressure in preventing chemotherapy-induced nausea and vomiting is uncertain. OBJECTIVE: To assess the effectiveness of acupressure on three categories of chemotherapy-induced nausea and vomiting. DATA SOURCES: Databases had been retrieved from inception through February 2016 for the randomized controlled trials in accordance with the inclusion criteria, including PubMed, Cochrane Central Register of Controlled Trials, Web of Science, EMBASE, Science Direct, CINAHL, China Biology Medicine, Chinese National Knowledge infrastructure, Wan Fang and Database for Chinese Technical Periodicals...
February 14, 2017: International Journal of Nursing Studies
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