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https://www.readbyqxmd.com/read/28806470/efficacy-and-safety-of-sugammadex-versus-neostigmine-in-reversing-neuromuscular-blockade-in-adults
#1
REVIEW
Ana-Marija Hristovska, Patricia Duch, Mikkel Allingstrup, Arash Afshari
BACKGROUND: Acetylcholinesterase inhibitors, such as neostigmine, have traditionally been used for reversal of non-depolarizing neuromuscular blocking agents. However, these drugs have significant limitations, such as indirect mechanisms of reversal, limited and unpredictable efficacy, and undesirable autonomic responses. Sugammadex is a selective relaxant-binding agent specifically developed for rapid reversal of non-depolarizing neuromuscular blockade induced by rocuronium. Its potential clinical benefits include fast and predictable reversal of any degree of block, increased patient safety, reduced incidence of residual block on recovery, and more efficient use of healthcare resources...
August 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28802016/involvement-of-sperm-acetylated-histones-and-the-nuclear-isoform-of-glutathione-peroxidase-4-in-fertilization
#2
Simona Pipolo, Rossella Puglisi, Valentina Mularoni, Valentina Esposito, Andrea Fuso, Marco Lucarelli, Maria Teresa Fiorenza, Franco Mangia, Carla Boitani
We previously demonstrated that the nuclear form of Glutathione Peroxidase 4 (nGPx4) has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome and that sperm lacking nGPx4 are more prone to decondensation in vitro. In this study we have hypothesized that sperm retained acetylated histones and nGPx4 are implicated in paternal chromatin decondensation and male pronucleus formation at fertilization. Indeed, significant higher amounts of acetylated histone H4 and acetylated histone H3 were observed by both immunofluorescence and western blotting in nGPx4-KO sperm vs WT ones...
August 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28796047/effects-of-calcium-on-the-incidence-of-recurrent-colorectal-adenomas-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#3
Sajesh K Veettil, Siew Mooi Ching, Kean Ghee Lim, Surasak Saokaew, Pochamana Phisalprapa, Nathorn Chaiyakunapruk
BACKGROUND: Protective effects of calcium supplementation against colorectal adenomas have been documented in systematic reviews; however, the results have not been conclusive. Our objective was to update and systematically evaluate the evidence for calcium supplementation taking into consideration the risks of systematic and random error and to GRADE the evidence. METHODS: The study comprised a systematic review with meta-analysis and trial sequential analysis (TSA) of randomized controlled trials (RCTs)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795711/rational-design-of-thermo-responsive-adsorbents-demand-oriented-active-sites-for-the-adsorption-of-dyes
#4
Yao Jiang, Shu-Feng Shan, Wei Liu, Jing Zhu, Qiu-Xia He, Peng Tan, Lei Cheng, Xiao-Qin Liu, Lin-Bing Sun
A smart adsorbent RA@MS is fabricated by incorporating a di-block copolymer through the combination of the thermo-responsive block poly(N-isopropylacrylamide) (R) and the active block poly{N-[3-(dimethylamino) propyl]methacrylamide} (A, tertiary amines as basic sites) into mesoporous silica. The di-block copolymer RA preserves the thermo-responsive nature, which makes the active sites reversibly exposed/blocked in light of temperature variation. The obtained adsorbent possessing thermo-responsive properties can thus realize both selective adsorption and efficient regeneration for temperature-swing adsorption (TSA) of dyes...
August 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28794581/comparison-of-general-versus-isolated-regional-anesthesia-in-total-shoulder-arthroplasty-a-retrospective-propensity-matched-cohort-analysis
#5
David Y Ding, Siddharth A Mahure, Brent Mollon, Steven D Shamah, Joseph D Zuckerman, Young W Kwon
BACKGROUND: Intraoperative anesthetic typically consists of either general anesthesia (GA) or isolated regional anesthesia (RA). METHODS: A retrospective propensity-matched cohort analysis on patients undergoing TSA was performed to determine differences between GA and RA in regard to patient population, complications, LOS and hospital readmission. RESULTS: 4158 patients underwent TSA with GA or isolated RA. Propensity-matching resulted in 912 patients in each cohort...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28791254/transcriptional-profiling-defines-histone-acetylation-as-a-regulator-of-gene-expression-during-human-to-mosquito-transmission-of-the-malaria-parasite-plasmodium-falciparum
#6
Che J Ngwa, Meike J Kiesow, Olga Papst, Lindsey M Orchard, Michael Filarsky, Alina N Rosinski, Till S Voss, Manuel Llinás, Gabriele Pradel
Transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by the intraerythrocytic gametocytes, which, once taken up during a blood meal, become activated to initiate sexual reproduction. Because gametocytes are the only parasite stages able to establish an infection in the mosquito, they are crucial for spreading the tropical disease. During gametocyte maturation, different repertoires of genes are switched on and off in a well-coordinated sequence, pointing to regulatory mechanisms of gene expression...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28791052/inhibition-of-histone-methyltransferase-histone-deacetylase-and-%C3%AE-catenin-synergistically-enhance-the-cardiac-potential-of-bone-marrow-cells
#7
Jinpu Yang, Keerat Kaur, John G Edwards, Carol A Eisenberg, Leonard M Eisenberg
Previously, we reported that treatment with the G9a histone methyltransferase inhibitor BIX01294 causes bone marrow mesenchymal stem cells (MSCs) to exhibit a cardiocompetent phenotype, as indicated by the induction of the precardiac markers Mesp1 and brachyury. Here, we report that combining the histone deacetylase inhibitor trichostatin A (TSA) with BIX01294 synergistically enhances MSC cardiogenesis. Although TSA by itself had no effect on cardiac gene expression, coaddition of TSA to MSC cultures enhanced BIX01294-induced levels of Mesp1 and brachyury expression 5...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28782076/shoulder-arthroplasty-in-patients-with-osteo-chondrodysplasias
#8
Bradley Schoch, Jean-David Werthel, Joaquin Sanchez-Sotelo, John W Sperling, Robert H Cofield, Mark Morrey
PURPOSE: Osteo-chondrodysplasias are a rare cause of limb malalignment, deformity and degenerative joint disease. Earlier in life, deformities may be managed with bony realignment and soft tissue releases; however, as degenerative changes progress, arthroplasty may be considered. There are limited reports examining shoulder arthroplasty in this population. This study aims to assess pain relief, function, and re-operation rate of shoulder arthroplasty in patients with osteo-chondrodysplasias...
August 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28777576/a-chiral-thiophene-sulfonamide-a-challenge-for-voa-calculations
#9
Joanna E Rode, Jan Cz Dobrowolski, Krzysztof Lyczko, Aleksandra Wasiewicz, Dorota Kaczorek, Robert Kawęcki, Grzegorz Zajac, Malgorzata Baranska
Two enantiomers of 2-methyl-N-(1-thien-2-ylethyl)propane-2-sulfonamide (TSA), were synthesized and their VCD, ROA, IR, and Raman spectra were registered. The solved (S)-TSA X-ray structure shows a disorder connected to the presence of two TSA conformers differing by a slight rotation of the thiophene ring. Two molecules in the units cell of monoclinic P21 crystal form a net of NH∙∙∙OS and C*H∙∙∙OS hydrogen bonds. Out of a series of computational levels tested to interpret the spectra, the B3LYP functional combined with the def2TZVP basis set satisfactorily reproduces the experimental VCD and ROA spectra...
August 4, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28772161/catalytic-amidolysis-of-amino-acid-p-nitroanilides-using-transition-state-analogue-imprinted-artificial-enzymes-cooperative-effect-of-pyridine-moiety
#10
Mathew Divya, Thomas Benny, Philip Christy, E P Aparna, K S Devaky
Enzyme-like polymer catalysts with the imprints of phosphonate transition state analogue (TSA) lined along with imidazole and pyridine moieties were synthesized using methacryloyl-l-histidine and 4-vinylpyridine as the functional monomers and phenyl-1-(N-benzyloxycarbonylamino)-2-(phenyl)ethyl phosphonate - the TSA of hydrolytic reaction as the template for the amidolysis of N-benzyloxycarbonyl-l-phenylalanine p-nitroanilide (Z-l-Phe-PNA). Polymers containing different functional groups can act together to provide catalytic activity and selectivity superior to what can be obtained from monofunctional analogues...
July 25, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28770000/cupping-therapy-versus-acupuncture-for-pain-related-conditions-a-systematic-review-of-randomized-controlled-trials-and-trial-sequential-analysis
#11
REVIEW
Ya-Jing Zhang, Hui-Juan Cao, Xin-Lin Li, Xiao-Ying Yang, Bao-Yong Lai, Guo-Yang Yang, Jian-Ping Liu
BACKGROUND: Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two therapies. OBJECTIVES: To compare the beneficial effectiveness and safety between cupping therapy and acupuncture for pain-related conditions to provide evidence for clinical practice. METHODS: Protocol of this review was registered in PROSPERO (CRD42016050986)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28764202/antimicrobial-effect-of-leaves-of-phyllanthus-niruri-and-solanum-nigrum-on-caries-causing-bacteria-an-in-vitro-study
#12
J Sunitha, Swathy Krishna, R Ananthalakshmi, J Sathiya Jeeva, As Smiline Girija, Nadeem Jeddy
INTRODUCTION: Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called 'manathakkali Keerai' in Tamil, forms an indispensable part of South Indian diet. Phyllanthus niruri (keezhanelli in Tamil) is a widely used medicinal plant, the leaves of which have been used extensively in Ayurveda and native medicine to cure various liver ailments. The herbs Solanumnigrum and Phyllanthus niruri have been found to be effective against numerous enteropathogens in various in vitro studies...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28752355/trichostatin-a-increases-embryo-and-green-plant-regeneration-in-wheat
#13
Fengying Jiang, Daria Ryabova, Jeremie Diedhiou, Pierre Hucl, Harpinder Randhawa, Elizabeth-France Marillia, Nora A Foroud, Francois Eudes, Palak Kathiria
Chemical agents such as trichostatin A (TSA) can assist in optimization of doubled haploidy for rapid improvements in wheat germplasm and addressing recalcitrance issues in cell culture responses. In wheat, plant regeneration through microspore culture is an integral part of doubled haploid (DH) production. However, low response to tissue culture and genotype specificity are two major constraints in the broad deployment of this breeding tool. Recently, the structure of chromatin was shown to be linked with cell transitions during tissue culture...
July 27, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28751092/the-incidence-and-effect-of-fatty-atrophy-positive-tangent-sign-and-rotator-cuff-tears-on-outcomes-after-total-shoulder-arthroplasty
#14
W Stephen Choate, Ellen Shanley, Richard Washburn, Stefan J Tolan, Tariq I Salim, Josh Tadlock, Elizabeth C Shealy, Catherine D Long, Ashley E Crawford, Michael J Kissenberth, Keith T Lonergan, Richard J Hawkins, John M Tokish
BACKGROUND: Treatment choices for total shoulder arthroplasty (TSA) in the absence of full-thickness rotator cuff tears (RCTs) are not clearly defined in current literature. This study investigated the prevalence and effect of preoperative partial-thickness RCTs and muscular degenerative changes on postoperative outcomes after TSA. METHODS: Medical records and magnetic resonance imaging studies were reviewed for patients who underwent TSA for primary glenohumeral osteoarthritis with minimum 2-year follow-up to determine preoperative tear classification, Goutallier grade, and supraspinatus tangent sign...
July 24, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28747276/tobacco-use-predicts-a-more-difficult-episode-of-care-after-anatomic-total-shoulder-arthroplasty
#15
Daniel B Wells, Andrew M Holt, Richard A Smith, Tyler J Brolin, Frederick M Azar, Thomas W Throckmorton
BACKGROUND: In the current health care environment, it is becoming increasingly important to recognize risks factors that may affect a patient's postoperative outcome. To determine the potential impact of tobacco as a risk factor, we evaluated postoperative pain, narcotic use, length of stay, reoperations, and complications in the global 90-day episode of care for patients undergoing anatomic total shoulder arthroplasty (TSA) who were current tobacco users, former users, or nonusers. METHODS: Database search identified 163 patients with primary anatomic TSA done for glenohumeral arthritis; these were divided into 3 groups: current tobacco users (28), nonusers (88), and former users (47)...
July 24, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28739297/the-impact-of-insulin-dependence-on-short-term-postoperative-complications-in-diabetic-patients-undergoing-total-shoulder-arthroplasty
#16
Michael C Fu, Venkat Boddapati, David M Dines, Russell F Warren, Joshua S Dines, Lawrence V Gulotta
BACKGROUND: The number of total shoulder arthroplasty (TSA) procedures performed is steadily increasing, and it is important to characterize predictors of postoperative complications for risk assessment models. Whereas diabetes has been associated with increased morbidity after TSA, the impact of insulin dependence on the risk profile of diabetic patients has not been described. METHODS: The National Surgical Quality Improvement Program database from 2011-2014 was used to identify 5918 TSA cases...
July 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28738787/procalcitonin-guided-antibiotic-therapy-in-critically-ill-adults-a-meta-analysis
#17
Tao Zhang, Yan Wang, Qianting Yang, Yalin Dong
BACKGROUND: As a novel biomarker of inflammation, procalcitonin (PCT) has proven useful to guide antibiotic therapy in intensive care unit (ICU). However, there are controversial on mortality. The aim of this study was to evaluate the utility of PCT-guided antibiotic therapy in critically ill adults and determine whether studies are sufficient. METHODS: A systematic search in PubMed, Embase and Cochrane was performed. We included only randomized controlled trials which compared the safety and efficacy between PCT-guided or standard antibiotic therapy groups in ICU adults...
July 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28738675/transparent-and-flexible-triboelectric-sensing-array-for-touch-security-applications
#18
Zuqing Yuan, Tao Zhou, Yingying Yin, Ran Cao, Congju Li, Zhong Lin Wang
Tactile sensor with large-scale array and high sensitivity is essential for human-machine interaction, smart wearable devices and mobile network. Here, a transparent and flexible triboelectric sensing array (TSA) with fingertip-sized pixels is demonstrated by integrating ITO electrodes, FEP film and signal-transmission circuits on an undivided palm-sized PET substrate. The sensing pixels can be triggered by the corresponding external contact to induce the electrostatic potential in the transparent electrodes without power consumption, which is individually recognized by the sensor...
July 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28735841/the-perioperative-effects-of-chronic-preoperative-opioid-use-on-shoulder-arthroplasty-outcomes
#19
Jonathan W Cheah, David C Sing, Dell McLaughlin, Brian T Feeley, C Benjamin Ma, Alan L Zhang
HYPOTHESIS AND BACKGROUND: Chronic opioid therapy is an increasingly used modality for the treatment of osteoarthritis-associated pain. We hypothesized that chronic opioid use would be associated with adverse outcomes in shoulder arthroplasty. METHODS: A retrospective analysis of patients undergoing elective anatomic total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (rTSA) at a single institution from 2012-2015 was performed. Patients were stratified by preoperative opioid use (nonusers, short-acting opioid users, and long-acting opioid users), and their postoperative clinical outcomes were assessed...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28735660/case-detection-and-diagnosis-of-primary-aldosteronism-the-consensus-of-taiwan-society-of-aldosteronism
#20
Vin-Cent Wu, Ya-Hui Hu, Leay Kiaw Er, Ruoh-Fang Yen, Chia-Hui Chang, Ya-Li Chang, Ching-Chu Lu, Chin-Chen Chang, Jui-Hsiang Lin, Yen-Hung Lin, Tzung-Dau Wang, Chih-Yuan Wang, Shih Te Tu, Shih-Chieh Jeff Chueh, Ching-Chung Chang, Fen-Yu Tseng, Kwan-Dun Wu
BACKGROUND/PURPOSE: Even though the increasing clinical recognition of primary aldosteronism (PA) as a public health issue, its heightened risk profiles and the availability of targeted surgical/medical treatment being more understood, consensus in its diagnosis and management based on medical evidence, while recognizing the constraints of our real-world clinical practice in Taiwan, has not been reached. METHODS: The Taiwan Society of Aldosteronism (TSA) Task Force acknowledges the above-mentioned issues and reached this Taiwan PA consensus at its inaugural meeting, in order to provide updated information of internationally acceptable standards, and also to incorporate our local disease characteristics into the management of PA...
July 20, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
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