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https://www.readbyqxmd.com/read/29137857/matricellular-proteins-and-survival-in-patients-with-pancreatic-cancer-a-systematic-review
#1
REVIEW
Sirio Fiorino, Maria Letizia Bacchi-Reggiani, Chiara Birtolo, Giorgia Acquaviva, Michela Visani, Adele Fornelli, Michele Masetti, Andrea Tura, Stefano Sbrignadello, Fabio Grizzi, Federica Patrinicola, Matteo Zanello, Laura Mastrangelo, Raffaele Lombardi, Claudia Benini, Luca Di Tommaso, Arrigo Bondi, Francesco Monetti, Elena Siopis, Paolo Emilio Orlandi, Michele Imbriani, Carlo Fabbri, Silvia Giovanelli, Andrea Domanico, Esterita Accogli, Salomone Di Saverio, Daniela Grifoni, Vincenzo Cennamo, Paolo Leandri, Elio Jovine, Dario de Biase
Extracellular matrix (ECM) plays a fundamental role in tissue architecture and homeostasis and modulates cell functions through a complex interaction between cell surface receptors, hormones, several bioeffector molecules, and structural proteins like collagen. These components are secreted into ECM and all together contribute to regulate several cellular activities including differentiation, apoptosis, proliferation, and migration. The so-called "matricellular" proteins (MPs) have recently emerged as important regulators of ECM functions...
November 4, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29137660/optimising-the-value-of-the-evidence-generated-in-implementation-science-the-use-of-ontologies-to-address-the-challenges
#2
EDITORIAL
Susan Michie, Marie Johnston
Implementing research findings into healthcare practice and policy is a complex process occurring in diverse contexts; it invariably depends on changing human behaviour in many parts of an intricate implementation system. Questions asked with the aim of improving implementation are multifarious variants of 'What works, compared with what, how well, with what exposure, with what behaviours (for how long), for whom, in what setting and why?'. Relevant evidence is being published at a high rate, but its quantity, complexity and lack of shared terminologies present challenges...
November 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29136208/mouse-phenome-database-an-integrative-database-and-analysis-suite-for-curated-empirical-phenotype-data-from-laboratory-mice
#3
Molly A Bogue, Stephen C Grubb, David O Walton, Vivek M Philip, Georgi Kolishovski, Tim Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29106641/the-mar-databases-development-and-implementation-of-databases-specific-for-marine-metagenomics
#4
Terje Klemetsen, Inge A Raknes, Juan Fu, Alexander Agafonov, Sudhagar V Balasundaram, Giacomo Tartari, Espen Robertsen, Nils P Willassen
We introduce the marine databases; MarRef, MarDBand MarCat (https://mmp.sfb.uit.no/databases/), which are publicly available resources that promote marine research and innovation. These data resources, which have been implemented in the Marine Metagenomics Portal (MMP) (https://mmp.sfb.uit.no/), are collections of richly annotated and manually curated contextual (metadata) and sequence databases representing three tiers of accuracy. While MarRef is a database for completely sequenced marine prokaryotic genomes, which represent a marine prokaryote reference genome database, MarDB includes all incomplete sequenced prokaryotic genomes regardless level of completeness...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29103588/vocabulary-knowledge-mediates-the-link-between-socioeconomic-status-and-word-learning-in-grade-school
#5
Mandy J Maguire, Julie M Schneider, Anna E Middleton, Yvonne Ralph, Michael Lopez, Robert A Ackerman, Alyson D Abel
The relationship between children's slow vocabulary growth and the family's low socioeconomic status (SES) has been well documented. However, previous studies have often focused on infants or preschoolers and primarily used static measures of vocabulary at multiple time points. To date, there is no research investigating whether SES predicts a child's word learning abilities in grade school and, if so, what mediates this relationship. In this study, 68 children aged 8-15 years performed a written word learning from context task that required using the surrounding text to identify the meaning of an unknown word...
November 2, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29099718/paronymy-in-the-sublanguage-of-medicine-linguistic-and-linguo-didactic-aspects
#6
O Bieliaieva, Yu Lysanets, K Havrylieva, I Znamenska, I Rozhenko, N Nikolaieva
The present paper examines the phenomenon of paronymy in the sublanguage of medicine. The study of paronyms plays an important role in the development of terminological competence of future specialists in the field of medicine and healthcare. The authors emphasize the need to pay due attention to terminological paronyms when compiling teaching manuals and developing didactic materials in Latin for students of medical universities. The urgency of organizing the work with these lexical units is determined, on the one hand, by the propaedeutic objective - minimization of difficulties that students may encounter in dealing with special terminology in the process of educational and professional communication; on the other hand, the study of paronyms is aimed at expanding the active and passive vocabulary of medical students...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29099674/the-role-of-paternal-age-in-the-prediction-of-offspring-intelligence
#7
Jamie M Gajos, Kevin M Beaver
Recent evidence suggests that paternal age at birth influences myriad developmental outcomes among children, but few studies have examined the possibility for father's age to influence children's intellectual development among a sample of high-risk families. The authors use data from the Fragile Families and Child Wellbeing Study to examine the association between paternal age at birth among 480 male and 449 female children's verbal IQ scores, as assessed with a version of the Peabody Picture Vocabulary Test at 9 years old...
November 2017: Journal of Genetic Psychology
https://www.readbyqxmd.com/read/29097355/a-clinical-reasoning-tool-for-virtual-patients-design-based-research-study
#8
Inga Hege, Andrzej A Kononowicz, Martin Adler
BACKGROUND: Clinical reasoning is a fundamental process medical students have to learn during and after medical school. Virtual patients (VP) are a technology-enhanced learning method to teach clinical reasoning. However, VP systems do not exploit their full potential concerning the clinical reasoning process; for example, most systems focus on the outcome and less on the process of clinical reasoning. OBJECTIVES: Keeping our concept grounded in a former qualitative study, we aimed to design and implement a tool to enhance VPs with activities and feedback, which specifically foster the acquisition of clinical reasoning skills...
November 2, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/29089912/the-relations-between-television-exposure-and-executive-function-in-chinese-preschoolers-the-moderated-role-of-parental-mediation-behaviors
#9
Xiaohui Yang, Zhe Chen, Zhenhong Wang, Liqi Zhu
The present study examined the relations between preschoolers' television exposure and executive functions (EF). One hundred and nineteen 3- to 6-year-old children and their parents participated. Parents filled in a questionnaire regarding children's television viewing time, television content and parental mediation behaviors about their child's television viewing. The children were asked to finish six EF tasks, including the backward digit span task, the spatial span task, the boy-girl Stroop, the Simon task, the flanker task and the Tower of Hanoi task that assessed working memory, inhibition and planning, respectively...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29083911/comics-cartoon-visualization-of-omics-data-in-spatial-context-using-anatomical-ontologies
#10
Dmitrii Travin, Iaroslav Popov, Arzu Tugce Guler, Dmitry Medvedev, Suzanne van der Plas-Duivesteijn, Monica Varela, Iris C R M Kolder, Annemarie H Meijer, Herman P Spaink, Magnus Palmblad
COMICS is an interactive and open-access Web platform for integration and visualization of molecular expression data in anatomograms of zebrafish, carp and mouse model systems. Anatomical ontologies are used to map omics data across experiments and between an experiment and a particular visualization in a data dependent manner. COMICS is built on top of several existing resources. Zebrafish and mouse anatomical ontologies with their controlled vocabulary (CV) and defined hierarchy are used with the ontoCAT R package to aggregate data for comparison and visualization...
October 30, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29083201/a-meta-analysis-on-the-relation-between-reading-and-working-memory
#11
Peng Peng, Marcia Barnes, CuiCui Wang, Wei Wang, Shan Li, H Lee Swanson, William Dardick, Sha Tao
The purpose of this study was to determine the relation between reading and working memory (WM) in the context of 3 major theories: the domain-specificity theory (debate) of WM, the intrinsic cognitive load theory, and the dual process theory. A meta-analysis of 197 studies with 2026 effect sizes found a significant moderate correlation between reading and WM, r = .29, 95% CI [.27, .31]. Moderation analyses indicated that after controlling for publication type, bilingual status, domains of WM, and grade level, the relation between WM and reading was not affected by types of reading...
October 30, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29081992/impact-of-a-malaria-intervention-package-in-schools-on-plasmodium-infection-anaemia-and-cognitive-function-in-schoolchildren-in-mali-a-pragmatic-cluster-randomised-trial
#12
Siân E Clarke, Saba Rouhani, Seybou Diarra, Renion Saye, Modibo Bamadio, Rebecca Jones, Diahara Traore, Klenon Traore, Matthew Ch Jukes, Josselin Thuilliez, Simon Brooker, Natalie Roschnik, Moussa Sacko
BACKGROUND: School-aged children are rarely targeted by malaria control programmes, yet the prevalence of Plasmodium infection in primary school children often exceeds that seen in younger children and could affect haemoglobin concentration and school performance. METHODS: A cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs)...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29081759/the-longitudinal-contribution-of-early-morphological-awareness-skills-to-reading-fluency-and-comprehension-in-greek
#13
George Manolitsis, Ioannis Grigorakis, George K Georgiou
The purpose of this longitudinal study was to examine the role of three morphological awareness (MA) skills (inflection, derivation, and compounding) in word reading fluency and reading comprehension in a relatively transparent orthography (Greek). Two hundred and fifteen (104 girls; Mage = 67.40 months, at kindergarten) Greek children were followed from kindergarten (K) to grade 2 (G2). In K and grade 1 (G1), they were tested on measures of MA (two inflectional, two derivational, and three compounding), letter knowledge, phonological awareness, rapid automatized naming (RAN), and general cognitive ability (vocabulary and non-verbal IQ)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29080334/locating-qualitative-studies-in-dementia-on-medline-embase-cinahl-and-psycinfo-a-comparison-of-search-strategies
#14
Morwenna Rogers, Alison Bethel, Rebecca Abbott
BACKGROUND: Qualitative research in dementia improves understanding of the experience of people affected by dementia. Searching databases for qualitative studies is problematic. Qualitative specific search strategies might help with locating studies. OBJECTIVE: To examine the effectiveness of five strategies across four major databases for retrieving qualitative studies in dementia. examine the effectiveness (sensitivity and precision) of five qualitative strategies on locating qualitative research studies in dementia in four major databases (MEDLINE, EMBASE, PsycINFO and CINAHL) METHODS: Qualitative dementia studies were checked for inclusion on MEDLINE, EMBASE, PsycINFO and CINAHL...
October 28, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29075209/early-executive-function-at-age-two-predicts-emergent-mathematics-and-literacy-at-age-five
#15
Hanna Mulder, Josje Verhagen, Sanne H G Van der Ven, Pauline L Slot, Paul P M Leseman
Previous work has shown that individual differences in executive function (EF) are predictive of academic skills in preschoolers, kindergartners, and older children. Across studies, EF is a stronger predictor of emergent mathematics than literacy. However, research on EF in children below age three is scarce, and it is currently unknown whether EF, as assessed in toddlerhood, predicts emergent academic skills a few years later. This longitudinal study investigates whether early EF, assessed at two years, predicts (emergent) academic skills, at five years...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29066580/intelligence-and-academic-achievement-with-asymptomatic-congenital-cytomegalovirus-infection
#16
Adriana S Lopez, Tatiana M Lanzieri, Angelika H Claussen, Sherry S Vinson, Marie R Turcich, Isabella R Iovino, Robert G Voigt, A Chantal Caviness, Jerry A Miller, W Daniel Williamson, Craig M Hales, Stephanie R Bialek, Gail Demmler-Harrison
OBJECTIVES: To examine intelligence, language, and academic achievement through 18 years of age among children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected infants. METHODS: We used growth curve modeling to analyze trends in IQ (full-scale, verbal, and nonverbal intelligence), receptive and expressive vocabulary, and academic achievement in math and reading. Separate models were fit for each outcome, modeling the change in overall scores with increasing age for patients with normal hearing (n = 78) or with sensorineural hearing loss (SNHL) diagnosed by 2 years of age (n = 11) and controls (n = 40)...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29065365/consolidating-new-words-from-repetitive-versus-multiple-stories-prior-knowledge-matters
#17
L M Henderson, E James
Prior knowledge is proposed to support the consolidation of newly acquired material. The current study examined whether children with superior vocabulary knowledge show enhanced overnight consolidation, particularly when new words are encountered in varying stories. Children aged 10 and 11 years (N = 42) were exposed to two sets of eight spoken novel words (e.g., "crocodol"), with one set embedded in the same story presented twice and the other presented in two different stories. Children with superior vocabulary knowledge showed larger overnight gains in explicit phonological and semantic knowledge when novel words had been encountered in multiple stories...
October 21, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29062600/l1-and-l2-reading-skills-in-dutch-adolescents-with-a-familial-risk-of-dyslexia
#18
Ellie R H van Setten, Wim Tops, Britt E Hakvoort, Aryan van der Leij, Natasha M Maurits, Ben A M Maassen
BACKGROUND: The present study investigated differences in reading and spelling outcomes in Dutch and English as a second language (ESL) in adolescents with a high familial risk of dyslexia, of whom some have developed dyslexia (HRDys) while others have not (HRnonDys), in comparison to a low familial risk control group without dyslexia (LRnonDys). This allowed us to investigate the persistence of dyslexia in the first language (L1) and the effect of dyslexia on the second language (L2), which has, in this case, a lower orthographic transparency...
2017: PeerJ
https://www.readbyqxmd.com/read/29056402/do-fathers-home-reading-practices-at-age-2-predict-child-language-and-literacy-at-age-4
#19
Jon Quach, Anna Sarkadi, Natasha Napiza, Melissa Wake, Amy Loughman, Sharon Goldfeld
BACKGROUND: Maternal shared reading practices predict emergent literacy, but fathers' contributions are less certain. We examined whether fathers' shared home reading activities at 2 years (1) predict language and emergent literacy at age 4 years, when controlling for maternal contributions; and (2) differentially benefit these outcomes in disadvantaged children. METHODS: Design: Two-parent families recruited from 5 relatively disadvantaged communities for the universal Let's Read literacy promotion population-based trial (ISRCTN 04602902) in Melbourne, Australia...
October 19, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29049493/preliminary-evidence-that-growth-in-productive-language-differentiates-childhood-stuttering-persistence-and-recovery
#20
Kathryn A Leech, Nan Bernstein Ratner, Barbara Brown, Christine M Weber
Purpose: Childhood stuttering is common but is often outgrown. Children whose stuttering persists experience significant life impacts, calling for a better understanding of what factors may underlie eventual recovery. In previous research, language ability has been shown to differentiate children who stutter (CWS) from children who do not stutter, yet there is an active debate in the field regarding what, if any, language measures may mark eventual recovery versus persistence. In this study, we examined whether growth in productive language performance may better predict the probability of recovery compared to static profiles taken from a single time point...
November 9, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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