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https://www.readbyqxmd.com/read/29319604/the-european-society-of-regional-anaesthesia-and-pain-therapy-american-society-of-regional-anesthesia-and-pain-medicine-recommendations-on-local-anesthetics-and-adjuvants-dosage-in-pediatric-regional-anesthesia
#1
Santhanam Suresh, Claude Ecoffey, Adrian Bosenberg, Per-Anne Lonnqvist, Gildasio S de Oliveira, Oscar de Leon Casasola, José de Andrés, Giorgio Ivani
BACKGROUND AND OBJECTIVES: Dosage of local anesthetics (LAs) used for regional anesthesia in children is not well determined. In order to evaluate and come to a consensus regarding some of these controversial topics, The European Society of Regional Anaesthesia and Pain Therapy (ESRA) and the American Society of Regional Anesthesia and Pain Medicine (ASRA) developed a Joint Committee Practice Advisory on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia. METHODS: Representatives from both ASRA and ESRA composed the joint committee practice advisory...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29279743/prevalence-of-lumbosacral-transitional-vertebra-in-individuals-with-low-back-pain-evaluation-using-plain-radiography-and-magnetic-resonance-imaging
#2
Asra Shaikh, Sohail Ahmed Khan, Munawar Hussain, Sadia Soomro, Hatem Adel, Syed Omair Adil, Farheen Huda, Usman Khanzada
Study Design: Descriptive cross-sectional study. Purpose: To determine the frequency of lumbosacral transitional vertebrae (LSTV) in patients with low back pain (LBP) and the role of iliolumbar ligament (ILL) origin from L5 in LSTV cases. Overview of Literature: Transitional vertebrae are developmental variants of the spine. LSTV is a common congenital abnormality, and failure to recognize this anomaly may result in serious consequences during surgery...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29278603/interventional-spine-and-pain-procedures-in-patients-on-antiplatelet-and-anticoagulant-medications-second-edition-guidelines-from-the-american-society-of-regional-anesthesia-and-pain-medicine-the-european-society-of-regional-anaesthesia-and-pain-therapy-the
#3
Samer Narouze, Honorio T Benzon, David Provenzano, Asokumar Buvanendran, José De Andres, Timothy Deer, Richard Rauck, Marc A Huntoon
The American Society of Regional Anesthesia and Pain Medicine (ASRA) 2012 survey of meeting attendees showed that existing ASRA anticoagulation guidelines for regional anesthesia were insufficient for their needs. Those surveyed agreed that procedure-specific and patient-specific factors required separate guidelines for pain and spine procedures. In response, a guidelines committee was formed. After preliminary review of published complications reports and studies, the committee stratified interventional spine and pain procedures according to potential bleeding risk: low-, intermediate-, and high-risk procedures...
December 22, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29215375/pushing-critical-thinking-skills-with-multiple-choice-questions-does-bloom-s-taxonomy-work
#4
Nikki L Bibler Zaidi, Karri L Grob, Seetha M Monrad, Joshua B Kurtz, Andrew Tai, Asra Z Ahmed, Larry D Gruppen, Sally A Santen
Medical school assessments should foster the development of higher-order thinking skills to support clinical reasoning and a solid foundation of knowledge. Multiple-choice questions (MCQs) are commonly used to assess student learning, and well-written MCQs can support learner engagement in higher levels of cognitive reasoning such as application or synthesis of knowledge. Bloom's taxonomy has been used to identify MCQs that assess students' critical thinking skills, with evidence suggesting that higher-order MCQs support a deeper conceptual understanding of scientific process skills...
December 5, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29202790/depression-point-prevalence-and-risk-factors-in-a-north-cyprus-household-adult-cross-sectional-study
#5
Mehmet Çakıcı, Özlem Gökçe, Asra Babayiğit, Ebru Çakıcı, Ayhan Eş
BACKGROUND: Depression is one of the most common diagnosed psychiatric disorders in the world. Besides individual risk factors, it is also found that environment and socio-cultural factors are the other main risk factors for depression. In this article, the results of the 2016 national household survey of depression in North Cyprus (NC) are presented. The aim of the study is to determine the prevalence and possible risk factors of depression in NC households. METHODS: The study was conducted between April and June 2016, the sample consisting of Turkish-speaking individuals between 18 and 88 years of age living permanently in NC...
December 4, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29135886/interpreting-the-mint-randomized-trials-evaluating-radiofrequency-ablation-for-lumbar-facet-and-sacroiliac-joint-pain-a-call-from-asra-for-better-education-study-design-and-performance
#6
David A Provenzano, Asokumar Buvanendran, Oscar A de León-Casasola, Samer Narouze, Steven P Cohen
No abstract text is available yet for this article.
January 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29080824/prediction-of-arsenic-and-antimony-transporter-major-intrinsic-proteins-from-the-genomes-of-crop-plants
#7
Abul Kalam Azad, Jahed Ahmed, Md Asraful Alum, Md Mahbub Hasan, Takahiro Ishikawa, Yoshihiro Sawa
Major intrinsic proteins (MIPs), commonly known as aquaporins, transport water and non-polar small solutes. Comparing the 3D models and the primary selectivity-related motifs (two Asn-Pro-Ala (NPA) regions, the aromatic/arginine (ar/R) selectivity filter, and Froger's positions (FPs)) of all plant MIPs that have been experimentally proven to transport arsenic (As) and antimony (Sb), some substrate-specific signature sequences (SSSS) or specificity determining sites (SDPs) have been predicted. These SSSS or SDPs were determined in 543 MIPs found in the genomes of 12 crop plants; the As and Sb transporters were predicted to be distributed in noduline-26 like intrinsic proteins (NIPs), and every plant had one or several As and Sb transporter NIPs...
October 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29056248/concise-syntheses-and-hcv-ns5b-polymerase-inhibition-of-2-r-3-and-2-s-2-ethynyluridine-10-and-related-nucleosides
#8
Frank Bennett, Alexei V Buevich, Hsueh-Cheng Huang, Vinay Girijavallabhan, Angela D Kerekes, Yuhua Huang, Asra Malikzay, Elizabeth Smith, Eric Ferrari, Mary Senior, Rebecca Osterman, Lingyan Wang, Jun Wang, Haiyan Pu, Quang T Truong, Paul Tawa, Stephane L Bogen, Ian W Davies, Ann E Weber
(2'R)-Ethynyl uridine 3, and its (2'S)-diastereomer 10, are synthesised in a divergent fashion from the inexpensive parent nucleoside. Both nucleoside analogues are obtained from a total of 5 simple synthetic steps and 3 trivial column chromatography purifications. To evaluate their effectiveness against HCV NS5B polymerase, the nucleosides were converted to their respective 5'-O-triphosphates. Subsequently, this lead to the discovery of the 2'-β-ethynyl 18 and -propynyl 20 nucleotides having significantly improved potency over Sofosbuvir triphosphate 24...
June 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29040146/the-role-of-preoperative-imaging-in-the-management-of-nonsyndromic-lambdoid-craniosynostosis
#9
Kavitha Ranganathan, Antonio Rampazzo, Asra Hashmi, Karin Muraszko, Jennifer Strahle, Christian J Vercler, Steven R Buchman
BACKGROUND: The necessity of imaging for patients with craniosynostosis is controversial. Lambdoid synostosis is known to be associated with additional anomalies, but the role of imaging in this setting has not been established. The purpose of this study was to evaluate the impact of preoperative imaging on intraoperative and postoperative management among patients undergoing operative intervention for lambdoid craniosynostosis. METHODS: A retrospective review of patients undergoing cranial vault remodeling for lambdoid craniosynostosis between January 2006 and 2014 was conducted...
October 16, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28979577/methodologies-in-orthodontic-pain-management-a-review
#10
Asra Sabir Hussain, Meteib Joraib Al Toubity, Wael Y Elias
INTRODUCTION: Patients experience pain and discomfort during active orthodontic treatment with fixed appliances. Pain is considered a subjective response to noxious stimuli. It can vary from person to person and is influenced by certain factors such as age, gender, previous pain experiences, stress or anxiety, and type of appliance. OBJECTIVE: The objective of this literature review was to discuss conventional versus recently introduced treatment modalities used in pain management for orthodontic patients...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28868190/upward-migration-and-peroral-extrusion-of-a-peritoneal-shunt-catheter-case-report-and-review-of-the-literature
#11
Asra Al Fauzi, Wihasto Suryaningtyas, Joni Wahyuhadi, M Arifin Parenrengi, Agus Turchan, Maria C Wijaya, Michael Jonatan, Mahyudanil, Hanis Setyono
BACKGROUND: Various complications after ventriculoperitoneal (VP) shunt surgery have been reported, but peroral extrusion of peritoneal catheter is an extremely rare complication, and only 20 cases have been reported since 1987. The pathophysiology still remains unclear and the management is challenging. CASE DESCRIPTION: A 5-year-old boy presented with a catheter coming out of his mouth. The boy had a posterior fossa tumor surgery and had VP shunt insertion 1 year earlier...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28856072/association-of-zika-virus-with-myocarditis-heart-failure-and-arrhythmias-a-literature-review
#12
REVIEW
Abdul M Minhas, Asra Nayab, Shobana Iyer, Mehek Narmeen, Kaneez Fatima, Muhammad S Khan, Jonathan Constantin
As the concerns regarding Zika virus (ZIKV) are mostly of neurological disorders, especially in neonates and infants, other possible threats of the virus may have been overlooked. Our study focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseases. We conducted a literature search of multiple terms in March 2017 using the search engines, PubMed, Embase, and SCOPUS. Articles were then reviewed by two independent reviewers, adhering strictly to our review criteria...
June 27, 2017: Curēus
https://www.readbyqxmd.com/read/28846841/charge-carriers-modulate-the-bonding-of-semiconductor-nanoparticle-dopants-as-revealed-by-time-resolved-x-ray-spectroscopy
#13
Asra Hassan, Xiaoyi Zhang, Xiaohan Liu, Clare E Rowland, Ali M Jawaid, Soma Chattopadhyay, Ahmet Gulec, Armen Shamirian, Xiaobing Zuo, Robert F Klie, Richard D Schaller, Preston T Snee
Understanding the electronic structure of doped semiconductors is essential to realize advancements in electronics and in the rational design of nanoscale devices. Reported here are the results of time-resolved X-ray absorption studies on copper-doped cadmium sulfide nanoparticles that provide an explicit description of the electronic dynamics of the dopants. The interaction of a dopant ion and an excess charge carrier is unambiguously observed via monitoring the oxidation state. The experimental data combined with DFT calculations demonstrate that dopant bonding to the host matrix is modulated by its interaction with charge carriers...
October 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28807891/a-collaborative-approach-to-identifying-social-media-markers-of-schizophrenia-by-employing-machine-learning-and-clinical-appraisals
#14
Michael L Birnbaum, Sindhu Kiranmai Ernala, Asra F Rizvi, Munmun De Choudhury, John M Kane
BACKGROUND: Linguistic analysis of publicly available Twitter feeds have achieved success in differentiating individuals who self-disclose online as having schizophrenia from healthy controls. To date, limited efforts have included expert input to evaluate the authenticity of diagnostic self-disclosures. OBJECTIVE: This study aims to move from noisy self-reports of schizophrenia on social media to more accurate identification of diagnoses by exploring a human-machine partnered approach, wherein computational linguistic analysis of shared content is combined with clinical appraisals...
August 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28775208/a-multikinase-and-dna-pk-inhibitor-combination-immunomodulates-melanomas-suppresses-tumor-progression-and-enhances-immunotherapies
#15
Alexander K Tsai, Asra Y Khan, Christina E Worgo, Lucy L Wang, Yuanyuan Liang, Eduardo Davila
Combination therapies have the potential to improve outcomes in melanoma patients but have not yet been clinically efficacious. Here, we used high-throughput flow cytometry-based screening to identify and characterize candidate therapies that might synergize with and augment T-cell immunotherapy efficacy. Two lead therapies, regorafenib (Reg) and NU7441, were selected based on their ability to alter a variety of immunomodulatory proteins, including CD55, CD73, CD155, programmed death-ligand 1 (PD-L1), nerve growth factor receptor (NGFR), and HLA class I in a heterogeneous panel of melanomas...
September 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28756915/in-silico-identification-and-characterization-of-common-epitope-based-peptide-vaccine-for-nipah-and-hendra-viruses
#16
Chayan Kumar Saha, Md Mahbub Hasan, Md Saddam Hossain, Md Asraful Jahan, Abul Kalam Azad
OBJECTIVE: To explore a common B- and T-cell epitope-based vaccine that can elicit an immune response against encephalitis causing genus Henipaviruses, Hendra virus (HeV) and Nipah virus (NiV). METHODS: Membrane proteins F, G and M of HeV and NiV were retrieved from the protein database and subjected to different bioinformatics tools to predict antigenic B-cell epitopes. Best B-cell epitopes were then analyzed to predict their T-cell antigenic potentiality. Antigenic B- and T-cell epitopes that shared maximum identity with HeV and NiV were selected...
June 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28749423/distinct-mechanisms-of-biotic-and-chemical-elicitors-enable-additive-elicitation-of-the-anticancer-phytoalexin-glyceollin-i
#17
Kelli Farrell, Md Asraful Jahan, Nik Kovinich
Phytoalexins are metabolites biosynthesized in plants in response to pathogen, environmental, and chemical stresses that often have potent bioactivities, rendering them promising for use as therapeutics or scaffolds for pharmaceutical development. Glyceollin I is an isoflavonoid phytoalexin from soybean that exhibits potent anticancer activities and is not economical to synthesize. Here, we tested a range of source tissues from soybean, in addition to chemical and biotic elicitors, to understand how to enhance the bioproduction of glyceollin I...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28727707/continuing-anti-thrombotic-medication-during-low-to-intermediate-risk-spinal-procedures-a-retrospective-evaluation
#18
Noud van Helmond, Wesley Day, Kenneth B Chapman
BACKGROUND: The current American Society of Regional Anesthesia (ASRA) guidelines recommend discontinuing anti-thrombotic therapy prior to any interventional spine procedures to decrease the incidence of bleeding complications. However, discontinuing anti-thrombotics may pose considerable danger in terms of cerebrovascular and cardiovascular events. Recent evidence suggests that some spinal interventions may still be performed safely with anti-thrombotics on board and some practitioners thus elect to continue certain anti-thrombotics for these procedures...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28712355/using-digital-media-advertising-in-early-psychosis-intervention
#19
Michael L Birnbaum, Chantel Garrett, Amit Baumel, Maria Scovel, Asra F Rizvi, Whitney Muscat, John M Kane
OBJECTIVE: Identifying and engaging youth with early-stage psychotic disorders in order to facilitate timely treatment initiation remains a major public health challenge. Although advertisers routinely use the Internet to directly target consumers, limited efforts have focused on applying available technology to proactively encourage help-seeking in the mental health community. This study explores how one might take advantage of Google AdWords in order to reach prospective patients with early psychosis...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28655336/a-survey-of-current-state-of-training-of-plastic-surgery-residents
#20
Asra Hashmi, Faraz A Khan, Floyd Herman, Nathan Narasimhan, Shaher Khan, Carrie Kubiak, Eti Gursel, David A Edelman
BACKGROUND: Plastic surgery training is undergoing major changes however there is paucity of data detailing the current state of training as perceived by plastic surgical trainees. Our aim was to determine the quality of training as perceived by the current trainee pool and their future plans. METHODS: A 25-item anonymous survey with three discrete sections (demographics, quality of training, and post-graduate career plans) was developed and distributed to plastic surgery residents during the academic year 2013...
June 27, 2017: BMC Research Notes
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