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Asra Hashmi, Rohan Policherla, Hector Campbell, Faraz A Khan, Adam Schumaier, Faisal Al-Mufarrej
OBJECTIVE: To evaluate the comprehensiveness of plastic surgery program websites. DESIGN: American Medical Association interactive database was accessed for the list of integrated plastic surgery programs, in June 2015. Since then, 67 plastic surgery program websites were accessed and searched for the presence or absence of 31 criteria, which were further grouped into 5 categories: First, program contact information; second, training and research; third, program setup; fourth, benefits and facilities; and fifth, information for applicants...
October 4, 2016: Journal of Surgical Education
Asra Akbar, George Nissan, Priyanka Chaudhry, Priya Rangasamy, Steven Mudrovich
We report a 41-year-old woman who developed histology- and colonoscopy-proven ischemic colitis with the use of naratriptan not exceeding the maximum 2 doses a day and 3 days per week and without a known medical or cardiovascular history. By exclusion of other causes of colonic ischemia, naratriptan was considered the sole causal agent. Discontinuation of naratriptan resulted in a complete clinical recovery. To date, our patient is the youngest known patient to develop ischemic colitis on isolated naratriptan in the setting of no known medical risk factors or predisposing medical condition...
October 2016: Proceedings of the Baylor University Medical Center
Ying Pan, Md Asraful Alam, Zhongming Wang, Jingcheng Wu, Yi Zhang, Zhenhong Yuan
In present study, esterification of oleic acid with methanol using deep eutectic solvent (DES) assisted Amberlyst heterogeneous catalyst was investigated to produce biodiesel. Results showed that esterification efficiency was enhanced by the DES. The combined effect of DES on Amberlyst BD20 (BD20) is better than Amberlyst 15 (A-15) due to different structure. The optimal reaction conditions were 12:1M ratio of methanol to oleic acid, 20%(wt/wt) catalyst (BD20-DES (2:8) and A-15-DES (8:2)) at 85°C for 100min with agitating at 200rpm...
November 2016: Bioresource Technology
Joanne Wilcox, Chantelle Waite, Lyndsey Tomlinson, Joanne Driscoll, Asra Karim, Edward Day, Adnan Sharif
BACKGROUND: Lifestyle modification is widely recommended to kidney allograft recipients post transplantation due to the cardiometabolic risks associated with immunosuppression including new-onset diabetes, weight gain and cardiovascular events. However, we have no actual evidence that undertaking lifestyle modification protects from any adverse outcomes post transplantation. The aim of this study is to compare whether a more proactive versus passive interventional approach to modify lifestyle is associated with superior outcomes post kidney transplantation...
2016: Trials
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Regional Anesthesia and Pain Medicine
Wafa Majeed, Asra Iftikhar, Tanweer Khaliq, Bilal Aslam, Humaira Muzaffar, Komal Atta, Aisha Mahmood, Shahid Waris
Gastric cancer is generally associated with poor survival rates and accounts for a remarkable proportion of global cancer mortality. The prevalence of gastric carcinoma varies in different regions of world and across teh various ethnic groups. On the basis of pathological assessment, gastric cancer can be categorized as intestinal and diffuse carcinomas. The etiology is diverse, including chemical carcinogen exposure, and high salt intake Helicobacter pylori also plays a vital role in the pathogenesis of certain gastric carcinomas...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Asra Hashmi, Farhan Essa Abdullah, Nihal Essa Abdullah, Shahana Urooj Kazmi
OBJECTIVE: To determine the incidence of Coagulase- negative S. aureusin urinary tract infections and sensitivities of these isolates to antimicrobial agents. STUDY DESIGN: Cohort study. PLACE AND DURATION OF STUDY: Dr. Essa Laboratory and Immunology and Infectious Disease Research Laboratory (IIDRL), Microbiology Department, University of Karachi, from January 2009 to January 2010. METHODOLOGY: Urine specimens, suggestive of urinary tract infection (UTI), were identified...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Taavi Ivan, Erki Enkvist, Birgit Viira, Ganesh Babu Manoharan, Gerda Raidaru, Alexander Pflug, Kazi Asraful Alam, Manuela Zaccolo, Richard Alan Engh, Asko Uri
The acknowledged potential of small-molecule therapeutics targeting disease-related protein-protein interactions (PPIs) has promoted active research in this field. The strategy of using small molecule inhibitors (SMIs) to fight strong (tight-binding) PPIs tends to fall short due to the flat and wide interfaces of PPIs. Here we propose a biligand approach for disruption of strong PPIs. The potential of this approach was realized for disruption of the tight-binding (KD = 100 pM) tetrameric holoenzyme of cAMP-dependent protein kinase (PKA)...
August 17, 2016: Bioconjugate Chemistry
Mohsen Ebrahimi, Amir Mirhaghi, Reza Mazlom, Abbas Heydari, Asra Nassehi, Mojtaba Jafari
Background. Triage nurses play a pivotal role in the emergency department. However some researchers have attempted to expand triage nurse's role; remarkable discrepancies exist among scholarly communities. The aim was to develop a role description of triage nurse relying on the experts. Methods. A modified Delphi study consisting of 3 rounds was performed from March to October 2014. In the first round, an extensive review of the literature was conducted. Expert selection was conducted through a purposeful sample of 38 emergency medicine experts...
2016: Scientifica
Weidong Lu, Md Asraful Alam, Ying Pan, Jingcheng Wu, Zhongming Wang, Zhenhong Yuan
The biomass of Chlorella sp. was pretreated with three different aqueous deep eutectic solvents (aDESs), i.e. aqueous choline chloride-oxalic acid (aCh-O), aqueous choline chloride-ethylene glycol (aCh-EG) and aqueous urea-acetamide (aU-A). The effect of aDESs pretreatment of microalgae biomass was evaluated in terms of lipid recovery rate, total carbohydrate content, fatty acid composition, and thermal chemical behavior of biomass. Results indicated that, lipid recovery rate was increased from 52.03% of untreated biomass to 80...
October 2016: Bioresource Technology
Faraz A Khan, Asra Hashmi, David A Edelman
Laparoscopic inguinal herniorraphy is a commonly performed procedure given the reported decrease in pain and earlier return to activity when compared with the open approach. Moreover, robotic assistance offers the operating surgeon considerable ergonomic advantages, making it an attractive alternative to conventional laparoscopic herniorraphy. Robotic herniorraphy utilizes the transabdominal preperitoneal approach where following repair peritoneal closure is necessary to avoid mesh exposure to the viscera. Self-anchoring sutures are frequently used to this end given the ease of use and knotless application...
2016: Journal of Surgical Case Reports
Abul Kalam Azad, Jahed Ahmed, Md Asraful Alum, Md Mahbub Hasan, Takahiro Ishikawa, Yoshihiro Sawa, Maki Katsuhara
Major intrinsic proteins (MIPs), commonly known as aquaporins, transport not only water in plants but also other substrates of physiological significance and heavy metals. In most of the higher plants, MIPs are divided into five subfamilies (PIPs, TIPs, NIPs, SIPs and XIPs). Herein, we identified 68, 42, 38 and 28 full-length MIPs, respectively in the genomes of four monocot grass plants, specifically Panicum virgatum, Setaria italica, Sorghum bicolor and Brachypodium distachyon. Phylogenetic analysis showed that the grass plants had only four MIP subfamilies including PIPs, TIPs, NIPs and SIPs without XIPs...
2016: PloS One
Behnam Honarvar, Negin Sayar, Sedigheh Tahmasebi, Zeinab Zakeri, Asra Talei, Sara Rostami, Sahar Khademi, Amene Sabzi Sarvestani, Eghbal Sekhavati
Globally, the burden of breast cancer (BC) continues to increase. BC related lymphedema (BCRL) is currently non curable and as a life time risk it affects at least 25% of BC patients. Knowing more about BCRL and appropriate control of its modifiable risk factors can improve quality of life (QOL) of the affected patients. In this case control study to detect factors, 400 women with BCRL (as the case group) and 283 patients with BC without lymphedema (as the control group) that were referred to Shiraz University of Medical Sciences affiliated BC clinic center were assessed...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Paul A Mann, Anna Müller, Kerstin A Wolff, Thierry Fischmann, Hao Wang, Patricia Reed, Yan Hou, Wenjin Li, Christa E Müller, Jianying Xiao, Nicholas Murgolo, Xinwei Sher, Todd Mayhood, Payal R Sheth, Asra Mirza, Marc Labroli, Li Xiao, Mark McCoy, Charles J Gill, Mariana G Pinho, Tanja Schneider, Terry Roemer
Here we describe a chemical biology strategy performed in Staphylococcus aureus and Staphylococcus epidermidis to identify MnaA, a 2-epimerase that we demonstrate interconverts UDP-GlcNAc and UDP-ManNAc to modulate substrate levels of TarO and TarA wall teichoic acid (WTA) biosynthesis enzymes. Genetic inactivation of mnaA results in complete loss of WTA and dramatic in vitro β-lactam hypersensitivity in methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE). Likewise, the β-lactam antibiotic imipenem exhibits restored bactericidal activity against mnaA mutants in vitro and concomitant efficacy against 2-epimerase defective strains in a mouse thigh model of MRSA and MRSE infection...
May 2016: PLoS Pathogens
Rajnish K Gupta, Matthew D McEvoy
BACKGROUND AND OBJECTIVES: Decision support tools have been demonstrated to improve adherence to medical guidelines; however, smartphone applications (apps) have not been studied in this regard. In a collaboration between Vanderbilt University and the American Society of Regional Anesthesia and Pain Medicine (ASRA), the ASRA Coags Regional app was created to be a decision support tool for the 2010 published guideline on regional anesthesia for patients receiving anticoagulation. This is a review of the distribution and usage of this app...
May 2016: Regional Anesthesia and Pain Medicine
Snezana M Bosnjak, Martha A Maurer, Karen M Ryan, Ivana Popovic, S Asra Husain, James F Cleary, Willem Scholten
Cancer is the second leading cause of death in Serbia, and at least 14,000-16,000 patients experience moderate-to-severe cancer pain every year. Cancer pain relief has been impeded by inadequate availability of opioid analgesics and barriers to their accessibility. In 2006, a Serbian oncologist was selected as an International Pain Policy Fellow. The fellow identified barriers to opioid availability in Serbia and implemented an action plan to address the unavailability of oral morphine, attitudinal and knowledge barriers about opioids, and barriers in the national opioid control policy, in collaboration with the government, local partners, and international experts, including those from the World Health Organization...
August 2016: Journal of Pain and Symptom Management
Stéphane L Bogen, Weidong Pan, Craig R Gibeau, Brian R Lahue, Yao Ma, Latha G Nair, Elise Seigel, Gerald W Shipps, Yuan Tian, Yaolin Wang, Yinghui Lin, Ming Liu, Suxing Liu, Asra Mirza, Xiaoying Wang, Philip Lipari, Cynthia Seidel-Dugan, Daniel J Hicklin, W Robert Bishop, Diane Rindgen, Amin Nomeir, Winifred Prosise, Paul Reichert, Giovanna Scapin, Corey Strickland, Ronald J Doll
A new subseries of substituted piperidines as p53-HDM2 inhibitors exemplified by 21 has been developed from the initial lead 1. Research focused on optimization of a crucial HDM2 Trp23-ligand interaction led to the identification of 2-(trifluoromethyl)thiophene as the preferred moiety. Further investigation of the Leu26 pocket resulted in potent, novel substituted piperidine inhibitors of the HDM2-p53 interaction that demonstrated tumor regression in several human cancer xenograft models in mice. The structure of HDM2 in complex with inhibitors 3, 10, and 21 is described...
March 10, 2016: ACS Medicinal Chemistry Letters
Hosein Shabaninejad, Asra Asgharzadeh, Nima Rezaei, Aziz Rezapoor
Subcutaneous immunoglobulin (SCIG) is a new therapeutic procedure for patients with primary immunodeficiency (PI). This research is a systematic review of studies on the efficacy and safety of intravenous immunoglobulin (IVIG) and SCIG in adult patients with PI. This study includes a systematic review of cohorts and randomized clinical trials (24 articles) from 5 databases with no time limits. Random effects meta-analysis was performed for outcomes such as efficacy and safety. Standard mean difference (SMD) of serum immunoglobulin level was equal to 0...
2016: Expert Review of Clinical Immunology
Charles J Ferro, Asra Karim, Daniela Farrugia, David Bagnall, Irena Begaj, Daniel Ray, Adnan Sharif
OBJECTIVES: Stroke is a major cause of mortality in the general population but data regarding stroke-related hospitalization or mortality after a kidney transplant is limited. We determined risk for stroke-related episodes after a kidney transplant in a population-based cohort study of 19,103 kidney allograft recipients in England between 2001 and 2012. MATERIALS AND METHODS: The incidence of stroke-related events after a kidney transplant with pretransplant history of stroke, the incidence of stroke-related hospitalization or death among all kidney allograft recipients after a kidney transplant, and risk factors for stroke-related mortality after a kidney transplant were examined...
February 2016: Experimental and Clinical Transplantation
James F Cleary, Asra Husain, Martha Maurer
No abstract text is available yet for this article.
April 16, 2016: Lancet
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