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https://www.readbyqxmd.com/read/28868190/upward-migration-and-peroral-extrusion-of-a-peritoneal-shunt-catheter-case-report-and-review-of-the-literature
#1
Asra Al Fauzi, Wihasto Suryaningtyas, Joni Wahyuhadi, M Arifin Parenrengi, Agus Turchan, Maria C Wijaya, Michael Jonatan, Mahyudanil, Hanis Setyono
BACKGROUND: Various complications after ventriculoperitoneal (VP) shunt surgery have been reported, but peroral extrusion of peritoneal catheter is an extremely rare complication, and only 20 cases have been reported since 1987. The pathophysiology still remains unclear and the management is challenging. CASE DESCRIPTION: A 5-year-old boy presented with a catheter coming out of his mouth. The boy had a posterior fossa tumor surgery and had VP shunt insertion 1 year earlier...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28856072/association-of-zika-virus-with-myocarditis-heart-failure-and-arrhythmias-a-literature-review
#2
REVIEW
Abdul M Minhas, Asra Nayab, Shobana Iyer, Mehek Narmeen, Kaneez Fatima, Muhammad S Khan, Jonathan Constantin
As the concerns regarding Zika virus (ZIKV) are mostly of neurological disorders, especially in neonates and infants, other possible threats of the virus may have been overlooked. Our study focuses on the potential threat that ZIKV may pose to the heart like that of similar arboviral diseases. We conducted a literature search of multiple terms in March 2017 using the search engines, PubMed, Embase, and SCOPUS. Articles were then reviewed by two independent reviewers, adhering strictly to our review criteria...
June 27, 2017: Curēus
https://www.readbyqxmd.com/read/28846841/charge-carriers-modulate-the-bonding-of-semiconductor-nanoparticle-dopants-as-revealed-by-time-resolved-x-ray-spectroscopy
#3
Asra Hassan, Xiaoyi Zhang, Xiaohan Liu, Clare E Rowland, Ali M Jawaid, Soma Chattopadhyay, Ahmet Gulec, Armen Shamirian, Xiaobing Zuo, Robert F Klie, Richard D Schaller, Preston T Snee
Understanding the electronic structure of doped semiconductors is essential to realize advancements in electronics and in the rational design of nanoscale devices. Reported here are the results of time-resolved X-ray absorption studies on copper-doped cadmium sulfide nanoparticles that provide an explicit description of the electronic dynamics of the dopants. The interaction of a dopant ion and an excess charge carrier is unambiguously observed via monitoring the oxidation state. The experimental data combined with DFT calculations demonstrate that dopant bonding to the host matrix is modulated by its interaction with charge carriers...
August 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28807891/a-collaborative-approach-to-identifying-social-media-markers-of-schizophrenia-by-employing-machine-learning-and-clinical-appraisals
#4
Michael L Birnbaum, Sindhu Kiranmai Ernala, Asra F Rizvi, Munmun De Choudhury, John M Kane
BACKGROUND: Linguistic analysis of publicly available Twitter feeds have achieved success in differentiating individuals who self-disclose online as having schizophrenia from healthy controls. To date, limited efforts have included expert input to evaluate the authenticity of diagnostic self-disclosures. OBJECTIVE: This study aims to move from noisy self-reports of schizophrenia on social media to more accurate identification of diagnoses by exploring a human-machine partnered approach, wherein computational linguistic analysis of shared content is combined with clinical appraisals...
August 14, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28775208/a-multikinase-and-dna-pk-inhibitor-combination-immunomodulates-melanomas-suppresses-tumor-progression-and-enhances-immunotherapies
#5
Alexander K Tsai, Asra Y Khan, Christina E Worgo, Lucy L Wang, Yuanyuan Liang, Eduardo Davila
Combination therapies have the potential to improve outcomes in melanoma patients but have not yet been clinically efficacious. Here, we used high-throughput flow cytometry-based screening to identify and characterize candidate therapies that might synergize with and augment T-cell immunotherapy efficacy. Two lead therapies, regorafenib (Reg) and NU7441, were selected based on their ability to alter a variety of immunomodulatory proteins, including CD55, CD73, CD155, programmed death-ligand 1 (PD-L1), nerve growth factor receptor (NGFR), and HLA class I in a heterogeneous panel of melanomas...
August 3, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28756915/in-silico-identification-and-characterization-of-common-epitope-based-peptide-vaccine-for-nipah-and-hendra-viruses
#6
Chayan Kumar Saha, Md Mahbub Hasan, Md Saddam Hossain, Md Asraful Jahan, Abul Kalam Azad
OBJECTIVE: To explore a common B- and T-cell epitope-based vaccine that can elicit an immune response against encephalitis causing genus Henipaviruses, Hendra virus (HeV) and Nipah virus (NiV). METHODS: Membrane proteins F, G and M of HeV and NiV were retrieved from the protein database and subjected to different bioinformatics tools to predict antigenic B-cell epitopes. Best B-cell epitopes were then analyzed to predict their T-cell antigenic potentiality. Antigenic B- and T-cell epitopes that shared maximum identity with HeV and NiV were selected...
June 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28749423/distinct-mechanisms-of-biotic-and-chemical-elicitors-enable-additive-elicitation-of-the-anticancer-phytoalexin-glyceollin-i
#7
Kelli Farrell, Md Asraful Jahan, Nik Kovinich
Phytoalexins are metabolites biosynthesized in plants in response to pathogen, environmental, and chemical stresses that often have potent bioactivities, rendering them promising for use as therapeutics or scaffolds for pharmaceutical development. Glyceollin I is an isoflavonoid phytoalexin from soybean that exhibits potent anticancer activities and is not economical to synthesize. Here, we tested a range of source tissues from soybean, in addition to chemical and biotic elicitors, to understand how to enhance the bioproduction of glyceollin I...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28727707/continuing-anti-thrombotic-medication-during-low-to-intermediate-risk-spinal-procedures-a-retrospective-evaluation
#8
Noud van Helmond, Wesley Day, Kenneth B Chapman
BACKGROUND: The current American Society of Regional Anesthesia (ASRA) guidelines recommend discontinuing anti-thrombotic therapy prior to any interventional spine procedures to decrease the incidence of bleeding complications. However, discontinuing anti-thrombotics may pose considerable danger in terms of cerebrovascular and cardiovascular events. Recent evidence suggests that some spinal interventions may still be performed safely with anti-thrombotics on board and some practitioners thus elect to continue certain anti-thrombotics for these procedures...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28712355/using-digital-media-advertising-in-early-psychosis-intervention
#9
Michael L Birnbaum, Chantel Garrett, Amit Baumel, Maria Scovel, Asra F Rizvi, Whitney Muscat, John M Kane
OBJECTIVE: Identifying and engaging youth with early-stage psychotic disorders in order to facilitate timely treatment initiation remains a major public health challenge. Although advertisers routinely use the Internet to directly target consumers, limited efforts have focused on applying available technology to proactively encourage help-seeking in the mental health community. This study explores how one might take advantage of Google AdWords in order to reach prospective patients with early psychosis...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28655336/a-survey-of-current-state-of-training-of-plastic-surgery-residents
#10
Asra Hashmi, Faraz A Khan, Floyd Herman, Nathan Narasimhan, Shaher Khan, Carrie Kubiak, Eti Gursel, David A Edelman
BACKGROUND: Plastic surgery training is undergoing major changes however there is paucity of data detailing the current state of training as perceived by plastic surgical trainees. Our aim was to determine the quality of training as perceived by the current trainee pool and their future plans. METHODS: A 25-item anonymous survey with three discrete sections (demographics, quality of training, and post-graduate career plans) was developed and distributed to plastic surgery residents during the academic year 2013...
June 27, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28628578/neuraxial-anesthesia-in-obstetric-patients-receiving-thromboprophylaxis-with-unfractionated-or-low-molecular-weight-heparin-a-systematic-review-of-spinal-epidural-hematoma
#11
REVIEW
Lisa R Leffert, Heloise M Dubois, Alexander J Butwick, Brendan Carvalho, Timothy T Houle, Ruth Landau
Venous thromboembolism remains a major source of morbidity and mortality in obstetrics with an incidence of 29.8/100,000 vaginal delivery hospitalizations; cesarean delivery confers a 4-fold increased risk of thromboembolism when compared with vaginal delivery. Revised national guidelines now stipulate that the majority of women delivering via cesarean and women at risk for ante- or postpartum venous thromboembolism receive mechanical or pharmacological thromboprophylaxis. This practice change has important implications for obstetric anesthesiologists concerned about the risk of spinal epidural hematoma (SEH) among anticoagulated women receiving neuraxial anesthesia...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28553396/a-rare-case-of-repeated-migration-and-transurethral-extrusion-of-ventriculoperitoneal-shunt
#12
Asra Al Fauzi, Wahjoe Djatisoesanto, Joni Wahyuhadi, Muhammad Arifin Parenrengi, Agus Turchan
Bladder migration and transurethral extrusion is an extremely rare complication of ventriculoperitoneal (VP) shunt. Only eight cases have been reported in the English literature since 1995. We report a case of a 4-year-old boy with cerebral palsy, hydrocephalus, and VP shunted on both sides who presented with a protruded distal VP shunt from his urethral orifice. The patient was reported for having previous shunt extrusion through the anus. The patient was treated on by a multidisciplinary approach, involving a neurosurgeon and urologist...
January 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28549045/effect-of-preoperative-molding-helmet-in-patients-with-sagittal-synostosis
#13
Asra Hashmi, Neena I Marupudi, Sandeep Sood, Arlene Rozzelle
BACKGROUND: In our practice, the authors found that molding helmet used for plagiocephaly preoperatively, in patients with sagittal synostosis, decreased bathrocephaly, forehead bossing, and improved posterior vertex, as well as Cephalic Index (CI). This prompted us to investigate the impact of preoperative molding helmet in patients with sagittal synostosis. METHODS: A prospective study was performed on patients undergoing surgical correction of sagittal synostosis, over a 5-year period...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28503661/in-vitro-detection-of-hypoxia-using-a-ratiometric-quantum-dot-based-oxygen-sensor
#14
Armen Shamirian, Hamid Samareh Afsari, Asra Hassan, Lawrence W Miller, Preston T Snee
A quantum-dot based ratiometric fluorescent oxygen probe for the detection of hypoxia in live cells is reported. The system is comprised of a water-soluble near-infrared emissive quantum dot conjugated to perylene dye. The response to the oxygen concentration is investigated using enzymatic oxygen scavenging in water, while in vitro studies were performed with HeLa cells incubated under varying O2 levels. In both cases a significant enhancement in dye/QD emission intensity ratio was observed in the deoxygenated environment, demonstrating the possible use of this probe for cancer research...
October 28, 2016: ACS Sensors
https://www.readbyqxmd.com/read/28492441/residual-enoxaparin-activity-anti-xa-levels-and-concerns-about-the-american-society-of-regional-anesthesia-and-pain-medicine-anticoagulation-guidelines
#15
Daryl S Henshaw, James D Turner, Daniel J Forest, Garrett R Thompson, Robert S Weller
Currently, the American Society of Regional Anesthesia and Pain Medicine (ASRA) anticoagulation guidelines recommend that before the performance of a neuraxial procedure a minimum of 24 hours should elapse following a treatment dose of enoxaparin (1 mg/kg twice daily or 1.5 mg/kg once daily). The guidelines have since their inception also consistently recommended against the routine use of anti-Xa level monitoring for patients receiving enoxaparin. However, we noted in our clinical practice that anti-Xa levels were frequently still elevated despite patients meeting the time-based recommendation for treatment dose enoxaparin...
July 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28433903/one-step-production-of-biodiesel-from-wet-and-unbroken-microalgae-biomass-using-deep-eutectic-solvent
#16
Ying Pan, Md Asraful Alam, Zhongming Wang, Dalong Huang, Keqin Hu, Hongxuan Chen, Zhenhong Yuan
One-step and Two-step methods were studied for lipid extraction from wet and unbroken (water content is 65-67%) Chlorella sp. and Chlorococcum sp. (GN38) using deep eutectic solvent (DES) treated microalgae cells. Further we optimized the extraction process and studied on its underlying mechanism. Among all DES, Choline chloride-Acetic acid (Ch-Aa) DES treatment showed optimal conditions at the mass ratio of DES: methanol-H2SO4 (2.00%) mixture: algae biomass was 60:40:3 with reaction time was 60min, and the optimum temperature was 110°C (Chlorococcum sp...
August 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28427624/ultrasound-assisted-biodiesel-production-by-a-novel-composite-of-fe-iii-based-mof-and-phosphotangestic-acid-as-efficient-and-reusable-catalyst
#17
Ahmad Nikseresht, Asra Daniyali, Mahdi Ali-Mohammadi, Ahmad Afzalinia, Abbas Mirzaie
In this work, esterification of oleic acid by various alcohols is achieved with high yields under ultrasonic irradiation. This reaction performed with a novel heterogeneous catalyst that fabricated by heteropoly acid and Fe(III)-based MOF, namely MIL-53 (Fe). Syntheses of MIL-53 and encapsulation process carry out by ultrasound irradiation at ambient temperature and atmospheric pressure. The prepared composite was characterized by various techniques such as XRD, FT-IR, SEM, BET and ICP that demonstrate excellent catalytic activities, while being highly convenient to synthesize...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28383303/early-hospital-readmissions-and-mortality-in-patients-with-decompensated-cirrhosis-enrolled-in-a-large-national-health-insurance-administrative-database
#18
Steven J Scaglione, Leanne Metcalfe, Stephanie Kliethermes, Ivan Vasilyev, Rebecca Tsang, Allyce Caines, Shaham Mumtaz, Vik Goyal, Asra Khalid, David Shoham, Talar Markossian, Amy Luke, Howard Underwood, Scott J Cotler
BACKGROUND: Patients with decompensated cirrhosis have high rates of morbidity and mortality and frequently require hospital admission. Few studies have examined early readmission as an indicator of 90 day and overall mortality. Analysis of large databases is needed to evaluate the association between early readmission and mortality in decompensated cirrhosis. METHODS: We analyzed 5 years of private, employer-based, health insurance claims data associated with HealthCare Services Corporation on 13...
October 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28339551/anticoagulant-and-antiplatelet-management-for-spinal-procedures-a-prospective-descriptive-study-and-interpretation-of-guidelines
#19
Bradly S Goodman, L McLean House, Sridhar Vallabhaneni, Srinivas Mallempati, Matthew R Willey, Matthew Thomas Smith
Setting: Epidural hematoma rarely complicates interventional spine procedures. While anticoagulant and antiplatelet drugs increase bleeding risk, cessation may precipitate serious thromboembolic events. The Spine Intervention Society (SIS) and American Society of Regional Anesthesia and Pain Medicine (ASRA) put forth guidelines that dissent with regard to management of hemostatically active agents during commonly performed spinal injections. Objective: To validate an antiplatelet/anticoagulant management table based on modifications of the SIS 2013 and ASRA 2015 guidelines...
July 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28319863/binding-affinity-and-adhesion-force-of-organophosphate-hydrolase-enzyme-with-soil-particles-related-to-the-isoelectric-point-of-the-enzyme
#20
Shah Md Asraful Islam, Shabina Yeasmin, Md Saiful Islam, Md Shariful Islam
The binding affinity of organophosphate hydrolase enzyme (OphB) with soil particles in relation to the isoelectric point (pI) was studied. Immobilization of OphB with soil particles was observed by confocal microscopy, Fourier transform infrared spectroscopy (FT-IR), and Atomic force microscopy (AFM). The calculated pI of OphB enzyme was increased from 8.69 to 8.89, 9.04 and 9.16 by the single, double and triple mutant of OphB enzyme, respectively through the replacement of negatively charged aspartate with positively charged histidine...
July 2017: Ecotoxicology and Environmental Safety
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