T Kubo, K Sunami, T Koyama, M Kitami, Y Fujiwara, S Kondo, K Yonemori, E Noguchi, C Morizane, Y Goto, A Maejima, S Iwasa, T Hamaguchi, A Kawai, K Namikawa, A Arakawa, M Sugiyama, M Ohno, T Yoshida, N Hiraoka, A Yoshida, M Yoshida, T Nishino, E Furukawa, D Narushima, M Nagai, M Kato, H Ichikawa, Y Fujiwara, T Kohno, N Yamamoto
BACKGROUND: Comprehensive genome profiling (CGP) serves as a guide for suitable genomically matched therapies for patients with cancer. However, little is known about the impact of the timing and types of cancer on the therapeutic benefit of CGP. MATERIALS AND METHODS: A single hospital-based pan-cancer prospective study (TOP-GEAR; UMIN000011141) was conducted to examine the benefit of CGP with respect to the timing and types of cancer. Patients with advanced solid tumors (>30 types) who either progressed with or without standard treatments were genotyped using a single CGP test...
April 12, 2024: ESMO Open