keyword
MENU ▼
Read by QxMD icon Read
search

Hydrogel

keyword
https://www.readbyqxmd.com/read/29223704/decellularized-heart-ecm-hydrogel-using-supercritical-carbon-dioxide-for-improved-angiogenesis
#1
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
Initial angiogenesis within the first 3 days is critical for healing ischemic diseases such as myocardial infarction. Recently, decellularized extracellular matrix (dECM) has been reported to provide tissue-derived ECM components and can be used as a scaffold for cell delivery for angiogenesis in tissue engineering. Decellularization by various detergents such as sodium dodecyl sulfate (SDS) and triton X-100 can remove the cell nuclei in tissue organs. However, this leads to ECM structure denaturation, decreased presence of various ECM proteins and cytokines, and loss of mechanical properties...
December 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29223037/a-microfabricated-platform-for-the-study-of-chondrogenesis-under-different-compressive-loads
#2
Reza Kowsari-Esfahan, Azadeh Jahanbakhsh, Mohammad Said Saidi, Shahin Bonakdar
Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29223036/study-on-temperature-and-near-infrared-driving-characteristics-of-hydrogel-actuator-fabricated-via-molding-and-3d-printing
#3
Qian Zhao, Yunhong Liang, Lei Ren, Feng Qiu, Zhihui Zhang, Luquan Ren
A hydrogel material system which was fit for molding and 3D printing was developed to fabricate bilayer hydrogel actuators with controllable temperature and near infrared laser responses. Polymerization on interface boundary of layered structure enhanced the bonding strength of hydrogel actuators. By utilizing anisotropic of microstructure along with thickness direction, bilayer hydrogel actuators fabricated via molding realized intelligent bending/shrinking responses, which guided the preparation of hydrogel ink for 3D printing...
December 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29222859/physicochemical-properties-and-cytotoxicity-of-hydrogels-based-on-beetosan%C3%A2-containing-sage-and-bee-pollen
#4
Bożena Tyliszczak, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Beata Grabowska, Magdalena Kędzierska
Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29222789/growth-and-neurotrophic-factors-in-embryonic-stem-cells
#5
Micaela Pannella, Luciana Giardino, Laura Calzà, Mercedes Fernández
In this chapter we illustrate protocols to investigate growth and neurotrophic factors in human and rodent (rat and mouse)-derived embryonic stem cells. The conventional two-dimensional cell monolayer system to grow embryonic stem cells is presented, focusing on the coating strategies also using extracellular matrix components. Then, different approaches for three-dimensional stem cell culture are presented, using hydrogels and scaffolds. Quantitative polymerase chain reaction, immunocytochemistry, immunoenzymatic ELISA assay, and multiparametric assays to quantify growth and neurotrophic factor production are presented...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222015/synthesis-and-evaluation-on-ph-and-temperature-responsive-chitosan-p-maa-co-nipam-hydrogels
#6
S Z M Rasib, Z Ahmad, A Khan, H M Akil, M B H Othman, Z A A Hamid, F Ullah
In this study, chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) [chitosan-p(MAA-co-NIPAM)] hydrogels were synthesized by emulsion polymerization. In order to be used as a carrier for drug delivery systems, the hydrogels had to be biocompatible, biodegradable and multi-responsive. The polymerization was performed by copolymerize MAA and NIPAM with chitosan polymer to produce a chitosan-based hydrogel. Due to instability during synthesis and complexity of components to produce the hydrogel, further study at different times of reaction is important to observe the synthesis process, the effect of end product on swelling behavior and the most important is to find the best way to control the hydrogel synthesis in order to have an optimal swelling behavior for drug release application...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221372/surface-attached-hydrogel-coatings-via-c-h-insertion-crosslinking-for-biomedical-and-bioanalytical-applications-review
#7
Oswald Prucker, Thomas Brandstetter, Jürgen Rühe
A novel method for the generation of surface-attached hydrogel coatings and their use in biomedical applications is discussed. This short review concentrates on surface architectures that are prepared from prepolymers carrying reactive groups suitable for crosslinking via C,H insertion reactions [C,H insertion crosslinking (CHic)]. Upon photochemical or thermal activation these groups do not only induce the crosslinking of the system, but also connect the forming gel to the surface as long as the surface itself consists of an organic material...
December 8, 2017: Biointerphases
https://www.readbyqxmd.com/read/29220201/engineering-hydrogel-microenvironments-to-recapitulate-the-stem-cell-niche
#8
Christopher M Madl, Sarah C Heilshorn
Stem cells are a powerful resource for many applications including regenerative medicine, patient-specific disease modeling, and toxicology screening. However, eliciting the desired behavior from stem cells, such as expansion in a naïve state or differentiation into a particular mature lineage, remains challenging. Drawing inspiration from the native stem cell niche, hydrogel platforms have been developed to regulate stem cell fate by controlling microenvironmental parameters including matrix mechanics, degradability, cell-adhesive ligand presentation, local microstructure, and cell-cell interactions...
December 8, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/29219743/building-a-polysaccharide-hydrogel-capsule-delivery-system-for-control-release-of-ibuprofen
#9
Zhi Chen, Ting Wang, Qing Yan
Development of a delivery system which can effectively carry hydrophobic drugs and have pH response is becoming necessary. Here we demonstrate that through preparation of β-cyclodextrin polymer (β-CDP), a hydrophobic drug molecule of ibuprofen (IBU) was incorporated into our prepared β-CDP inner cavities, aiming to improve the poor water solubility of IBU. A core-shell capsule structure has been designed for achieving the drug pH targeted and sustained release. This delivery system was built with polysaccharide polymer of Sodium alginate (SA), sodium carboxymethylcellulose (CMC) and hydroxyethyl cellulose (HEC) by physical cross-linking...
December 8, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29219628/penetration-enhancer-containing-spanlastics-pecss-for-transdermal-delivery-of-haloperidol-in-vitro-characterization-ex-vivo-permeation-and-in-vivo-biodistribution-studies
#10
Abdurrahman M Fahmy, Doaa Ahmed El-Setouhy, Ahmed B Ibrahim, Basant A Habib, Saadia A Tayel, Noha A Bayoumi
Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release. PECSs were successfully prepared using ethanol injection method showing reasonable values of percentage entrapment efficiency, particle size, polydispersity index and zeta potential. The statistical analysis of the ex vivo permeation parameters led to the choice of F1L - made of Span® 60 and Tween® 80 at the weight ratio of 4:1 along with 1% w/v Labrasol® - as the selected formula (SF)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29219317/single-step-binary-electrostatic-directed-assembly-of-active-nanogels-for-smart-concentration-dependent-encryption
#11
Daniel Morales, Lauryanne Teulon, Etienne Palleau, Thomas Alnasser, Laurence Ressier
Anionic and cationic (N-isopropylacrylamide derivatives) active colloidal hydrogel nanoparticles, i.e., nanogels, are electrostatically assembled on surfaces to form microscale patterns with complex geometries. While using mixed dispersions of these two kinds of nanogels, we demonstrate the capability of sorting the nanogels in one step to form separated binary nanogel patterns on a surface. These patterns appear independently or simultaneously depending on the relative proportion of each nanogel type in the mixture...
December 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29218684/feasibility-of-arthroscopic-autologous-chondrocyte-implantation-in-the-hip-using-an-injectable-hydrogel
#12
Steffen Thier, Florian Baumann, Christel Weiss, Stefan Fickert
INTRODUCTION: In the long term the treatment of articular cartilage defects of the hip has the most direct impact on the postoperative outcome and should diminish degenerative changes caused by different pathologies. The purpose of this prospective feasibility study is to describe technical aspects of arthroscopic, injectable autologous chondrocyte implantation in the hip and to report the short-term outcome. METHODS: Full-thickness cartilage defects of 13 patients were treated arthroscopically with an injectable autologous chondrocyte transplantation product (Novocart Inject, Tetec) in a 2-step surgical procedure...
December 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29218519/glucose-transport-activity-measured-in-giant-vesicles
#13
Jesper S Hansen, Karin Lindkvist-Petersson
Incorporation of membrane proteins and internal reporter systems directly into giant vesicles, during their formation from a hydrogel surface, has emerged as a promising new concept in membrane protein characterization. Here, we provide the detailed protocol for a glucose transporter activity assay based on giant vesicles containing a fluorescent enzyme-linked reporter system internally. This assay is applicable for the functional analysis of a variety of hexose-transporting proteins. We furthermore believe that it can aid in the development of drugs targeting hexose transporters...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29217475/in-vitro-drug-release-and-in-vivo-safety-of-vitamin-e-and-cysteamine-loaded-contact-lenses
#14
Phillip Dixon, Richard C Fentzke, Arnab Bhattacharya, Aditya Konar, Sarbani Hazra, Anuj Chauhan
Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. This paper focuses on designing a contact lens to treat the disease with improved efficacy compared to eye drops, and also exploring safety of the drug eluding contact lens in an animal model...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217184/formulation-of-novel-chitosan-guargum-based-hydrogels-for-sustained-drug-release-of-paracetamol
#15
Amtul Jamil Sami, Madeeha Khalid, Tahir Jamil, Saira Aftab, Sermad Ahmad Mangat, A R Shakoori, S Iqbal
The report presents the formulation of hydrogel based on biopolymers chitosan and guar gum after cross-linking for sustained release of a commonly used orally prescribed analgesic Paracetamol. The oral ingestion of Paracetamol is associated with complications of the gastric tract and liver metabolism that can be effectually avoided by using transdermal drug delivery systems. The formulated transdermal patch was characterized by physicochemical properties including swelling, bonding pattern (using FTIR Fourier Transform Infra-Red and Scanning Electron Microscopy SEM) and antimicrobial activity...
December 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29217022/focal-limbal-stem-cell-deficiency-associated-with-soft-contact-lens-wear
#16
Karolien Termote, Steven Schendel, Gregory Moloney, Simon P Holland, Alex P Lange
OBJECTIVE: The aim of this study is to summarize the clinical characteristics of patients with contact lens-associated focal limbal stem cell deficiency (FLSCD) from a tertiary corneal referral centre. DESIGN: Retrospective, observational case series in a tertiary care centre. METHODS: Patients with contact lens-associated FLCSD were identified in our database. Clinical data were retrieved by chart review. A questionnaire asking for contact lens brand, type, cleaning solution, and duration of contact lens wear was sent to the patients with telephone follow-up...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216752/an-acryl-resin-based-swellable-microneedles-for-controlled-release-intradermal-delivery-of-granisetron
#17
Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao
Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60 min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that 7 days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1...
December 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29216591/concomitant-monitoring-of-implant-formation-and-drug-release-of-in-situ-forming-poly-lactide-co-glycolide-acid-implants-in-a-hydrogel-matrix-mimicking-the-subcutis-using-uv-vis-imaging
#18
Yu Sun, Henrik Jensen, Nickolaj J Petersen, Susan W Larsen, Jesper Østergaard
For poly (lactide-co-glycolide acid) (PLGA)-based in situ forming implants, the rate of implant formation plays an important role in determining the overall drug release kinetics. Currently, in vitro techniques capable of characterizing the processes of drug release and implant formation at the same time are not available. A hydrogel-based in vitro experimental setup was recently developed requiring only microliter of formulation and forming a closed system potentially suitable for interfacing with various spectroscopic techniques...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29216578/preparation-and-characterization-of-xanthan-gum-cl-poly-acrylic-acid-o-mwcnts-hydrogel-nanocomposite-as-highly-effective-re-usable-adsorbent-for-removal-of-methylene-blue-from-aqueous-solutions
#19
Edwin Makhado, Sadanand Pandey, Philiswa N Nomngongo, James Ramontja
In this work, xanthan gum-cl-poly acrylic acid (XG-cl-pAA) hydrogel and xanthan gum-cl-poly acrylic acid/oxidized MWCNTs (XG-cl-pAA/o-MWCNTs) hydrogel nanocomposite was successfully surface modify by microwave assisted copolymerization, in which N, N'-methylenebisacrylamide (MBA) was used as a cross-linking agent. A copolymerization of acrylic acid (AA) onto xanthan gum (XG) initiated by microwave radiation method. Different weight percentages of oxidized MWCNTs were incorporated into the hydrogel matrix during the grafting reaction...
November 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29216567/biocompatible-nanocomposite-of-tio2-incorporated-bi-polymer-for-articular-cartilage-tissue-regeneration-a-facile-material
#20
Lei Cao, Xiaofeng Wu, Qiugen Wang, Jiandong Wang
The development and design of polymeric hydrogels for articular cartilage tissue engineering have been a vital biomedical research for recent days. Organic/inorganic combined hydrogels with improved surface activity have shown potential for the repair and regeneration of hard tissues, but have not been broadly studied for articular cartilage tissue engineering applications. In this work, bi-polymeric hydrogel composite was designed with the incorporation some quantities of stick-like TiO2 nanostructures for favorable surface behavior and enhancement of osteoblast adhesions...
October 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
keyword
keyword
6141
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"