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https://www.readbyqxmd.com/read/28823104/novel-polymeric-composites-based-on-carboxymethyl-chitosan-and-poly-acrylic-acid-in-vitro-and-in-vivo-evaluation
#1
Qurat-Ul-Ain Sharif, Muhammad Sohail, Mahmood Ahmad, Muhammad Usman Minhas, Shahzeb Khan, Samiullah Khan, Mubeen Kousar
The purpose of the study was to develop a novel, efficient, stable, chemically crosslinked polymeric system that have pH responsive behaviour and can effectively release 5-FU in a controlled manner. Furthermore it can target colonic cancer minimizing the side effects of in vivo chemotherapy via 5-FU. Swelling and drug release studies were performed to evaluate its in vitro release behaviour. Hydrogels were also characterized by FTIR, SEM and DSC. In vitro cytocompatibility and cytotoxicity of the hydrogels were determined by MTT assay using HeLa cells...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28823088/electrical-signals-triggered-controllable-formation-of-calcium-alginate-film-for-wound-treatment
#2
Xiaoli Liu, Huan Liu, Xue Qu, Miao Lei, Chuchu Zhang, Hua Hong, Gregory F Payne, Changsheng Liu
Wound dressings play important roles in the management of wounds, and calcium cross-linked alginate (Ca(2+)-Alg) is a commonly used hydrogel that is adapted for wound treatment. However, conventional methods for fabricating Ca(2+)-Alg hydrogels can be tedious and difficult to control because of the rapid Ca(2+)-induced gelation of alginate. In this study, An electrodeposition method was used to rapidly and controllably fabricate Ca(2+)-Alg films for wound treatment. Several measures of film growth (e.g., thickness and mass) are shown to linearly correlate to the imposed charge transfer at the electrode...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28822899/a-coupled-diffusion-fluid-pressure-model-to-predict-cell-density-distribution-for-cells-encapsulated-in-a-porous-hydrogel-scaffold-under-mechanical-loading
#3
Feihu Zhao, Ted J Vaughan, Myles J Mc Garrigle, Laoise M McNamara
Tissue formation within tissue engineering (TE) scaffolds is preceded by growth of the cells throughout the scaffold volume and attachment of cells to the scaffold substrate. It is known that mechanical stimulation, in the form of fluid perfusion or mechanical strain, enhances cell differentiation and overall tissue formation. However, due to the complex multi-physics environment of cells within TE scaffolds, cell transport under mechanical stimulation is not fully understood. Therefore, in this study, we have developed a coupled multiphysics model to predict cell density distribution in a TE scaffold...
August 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28822749/dominance-of-layer-specific-microvessel-dilation-in-contrast-enhanced-high-resolution-fmri-comparison-between-hemodynamic-spread-and-vascular-architecture-with-clarity
#4
REVIEW
Alexander John Poplawsky, Mitsuhiro Fukuda, Bok-Man Kang, Jae Hwan Kim, Minah Suh, Seong-Gi Kim
Contrast-enhanced cerebral blood volume-weighted (CBVw) fMRI response peaks are specific to the layer of evoked synaptic activity (Poplawsky et al., 2015), but the spatial resolution limit of CBVw fMRI is unknown. In this study, we measured the laminar spread of the CBVw fMRI evoked response in the external plexiform layer (EPL, 265 ± 65 μm anatomical thickness, mean ± SD, n = 30 locations from 5 rats) of the rat olfactory bulb during electrical stimulation of the lateral olfactory tract and examined its potential vascular source...
August 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28822704/corneal-confocal-microscopy-and-dry-eye-findings-in-contact-lens-discomfort-patients
#5
Aysun Sanal Dogan, Canan Gurdal, Nese Arslan
OBJECTIVES: To evaluate the corneal confocal microscopy and dry eye findings in patients with contact lens discomfort. METHODS: The study included 3 groups of participants: Contact lens wearers using silicone hydrogel soft contact lenses who are symptomatic (CLD, n=15) or asymptomatic (ACL, n=11) and non-wearers as controls (n=14). Duration of contact lens wear, Ocular Surface Disease Index (OSDI) questionnaire responses, fluorescein tear break-uptime (FBUT), and corneal confocal microscopy findings were recorded...
August 16, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28821778/electrochemical-removal-of-stains-from-paper-cultural-relics-based-on-the-electrode-system-of-conductive-composite-hydrogel-and-pbo2
#6
Xingtang Liang, Lizhen Zheng, Shirong Li, Xiaoyu Fan, Shukun Shen, Daodao Hu
Constructing methods for cleaning stains on paper artworks that meet the requirements of preservation of cultural relics are still challenging. In response to this problem, a novel electrochemical cleaning method and the preparation of corresponding electrodes were proposed. For this purpose, the conductive graphene (rGO)/polyacryamide (PAM)/montmorillonite (MMT) composite hydrogel as cathode and PbO2-based material as anode were prepared and characterized. The electrochemical cleaning efficiencies of real sample and mimicking paper artifacts were evaluated, and the effects of the electrochemical cleaning on paper itself were detected...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821436/carbon-quantum-dot-tailored-calcium-alginate-hydrogel-for-ph-responsive-controlled-delivery-of-vancomycin
#7
Niladri Sarkar, Gyanaranjan Sahoo, Rashmita Das, Gyanaranjan Prusty, Sarat K Swain
Herein, we demonstrate the preparation of highly luminescent carbon quantum dots (CQDs) from Aloe vera leaf gel; in just 2h at 250°C through carbonization pathway. The prepared CQDs are structurally characterized with high resolution transmission electron microscopy (HRTEM), hydrodynamic diameter and surface polarity, Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), Raman, UV-visible absorption spectrophotometry and fluorescence spectroscopy. The functional carbon nanoparticles are observed as non-cytotoxic materials...
August 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28821213/molecular-modeling-to-predict-peptide-accessibility-for-peptide-functionalized-hydrogels
#8
Xianfeng Li, Jia Jia, Ying Mei, Robert A Latour
Peptide-functionalized (PF) hydrogels are being widely investigated by the tissue engineering and regenerative medicine communities for a broad range of applications because of their unique potential to mimic the natural extracellular matrix and promote tissue regeneration. In order for these complex material systems to perform their intended bioactive function (e.g., cell signaling), the peptides that are tethered to the hydrogel matrix must be accessible at the hydrogel surface for cell-receptor binding. The factors influencing the surface accessibility of the tethered peptide mainly include the length of the tethers, the loading (i...
August 18, 2017: Biointerphases
https://www.readbyqxmd.com/read/28821157/in-situ-formation-of-injectable-and-porous-heparin-based-hydrogel
#9
Meeichyn Goh, Younghee Kim, Kihak Gwon, Kiyoon Min, YoungMin Hwang, Giyoong Tae
In this study, by combining photopolymerization and particle leaching technique, in situ formation of porous hydrogel with pore interconnectivity was demonstrated in vivo upon subcutaneous injection into the back of mice as well as in vitro. A precursor solution containing thiolated heparin, PEG-diacrylate (PEG-DA), and gelatin microparticles (GMPs) as a fast dissolving porogen were photopolymerized by visible-light-initiated thiol-ene reaction with eosin Y (EY) as a photo initiator and triethanolamine (TEOA) as a co-initiator...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821154/design-and-characterization-of-a-biocompatible-physical-hydrogel-based-on-scleroglucan-for-topical-drug-delivery
#10
Patrizia Paolicelli, Gabriele Varani, Settimio Pacelli, Elisa Ogliani, Martina Nardoni, Stefania Petralito, Alessandra Adrover, Maria Antonietta Casadei
Physical hydrogels of a high-carboxymethylated derivative of scleroglucan (Scl-CM300) were investigated as potential systems for topical drug delivery using three different therapeutic molecules (fluconazole, diclofenac and betamethasone). Rheological tests were carried out on drug-loaded hydrogels along with in-vitro release studies in a vertical Franz cell, in order to investigate if and how different drugs may influence the rheological and release properties of Scl-CM300 hydrogels. Experimental results and theoretical modeling highlighted that, in the absence of drug/polymer interactions (as for fluconazole and betamethasone) Scl-CM300 matrices offer negligible resistance to drug diffusion and a Fickian transport model can be adopted to estimate the effective diffusion coefficient in the swollen hydrogel...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821147/uv-crosslinkable-and-thermo-responsive-chitosan-hybrid-hydrogel-for-nir-triggered-localized-on-demand-drug-delivery
#11
Lei Wang, Baoqiang Li, Feng Xu, Zheheng Xu, Daqing Wei, Yujie Feng, Yaming Wang, Dechang Jia, Yu Zhou
Innovative drug delivery technologies based on smart hydrogels for localized on-demand drug delivery had aroused great interest. To acquire smart UV-crosslinkable chitosan hydrogel for NIR-triggered localized on-demanded drug release, a novel UV-crosslinkable and thermo-responsive chitosan was first designed and synthesized by grafting with poly N-isopropylacrylamide, acetylation of methacryloyl groups and embedding with photothermal carbon. The UV-crosslinkable unit (methacryloyl groups) endowed chitosan with gelation via UV irradiation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821138/biocompatible-chitin-carbon-nanotubes-composite-hydrogels-as-neuronal-growth-substrates
#12
Shuangquan Wu, Bo Duan, Ang Lu, Yanfeng Wang, Qifa Ye, Lina Zhang
In the past decades, extensive studies have demonstrated that carbon nanotubes (CNTs) could promote cell adhesion, proliferation and differentiation of neuronal cells. However, the potential cytotoxicity in biological systems severely restricted the utilization of CNTs as substrates for neural growth. In this study, biocompatible chitin/carbon nanotubes (Ch/CNT) composite hydrogels were developed via blending modified CNTs with chitin solution in 11wt% NaOH/4wt% urea aqueous system, and subsequently regenerating in ethanol...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821134/graphene-cyclodextrin-based-nanocomposite-hydrogel-with-enhanced-strength-and-thermo-responsive-ability
#13
Pang Zhu, Yonghong Deng, Chaoyang Wang
Dual crosslinked system has been proved to be an efficient method to obtain tough and high strength hydrogels. Herein, we synthesized a novel graphene oxide/p(acrylamide-co-poly(ethylene glycol) methyl ether methacrylate)/α-cyclodextrin (GO/P(AM-co-PEGMA)/CD) physical dual crosslinked hydrogel via copolymerization of AM and PEGMA in the α-CD/GO solution. The polymer main chains adsorb onto the GO surface resulting in the first crosslinked system and multiple hydrogen bonds between α-CDs that thread on the PEGMA side chains establish the second crosslinked system...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821122/-click-hyaluronan-based-nanohydrogels-as-multifunctionalizable-carriers-for-hydrophobic-drugs
#14
Giuliana Manzi, Nicole Zoratto, Silvia Matano, Rocchina Sabia, Claudio Villani, Tommasina Coviello, Pietro Matricardi, Chiara Di Meo
Highly hydrophilic and biocompatible nanocarriers based on polysaccharide hydrogels (nanohydrogels, NHs) were shown to be promising systems for drug delivery applications. Following the idea of these emerging drug carriers, the aim of the present work was to develop self-assembled hydrogel nanoparticles based on amphiphilic derivatives of hyaluronic acid (HA) and riboflavin (Rfv), synthesized by "click" Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) reaction. The obtained amphiphilic product (HA-c-Rfv) was able to form nanohydrogels in aqueous environments, in particular by applying an innovative autoclave-based method...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821114/preparation-and-characterization-of-a-composite-biomaterial-including-starch-micro-nano-particles-loaded-chitosan-gel
#15
Dorsa Dehghan Baniani, Reza Bagheri, Atefeh Solouk
Thermosensitive Chitosan hydrogels which can be injected into defects with minimally invasive approach were prepared. Also starch micro/nano particles were synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles were incorporated into the chitosan hydrogel to prepare injectable thermosensitive hydrogel composites. Tube inverting method, compression tests, swelling studies, XRD, SEM, OM, DLS, UV-vis spectroscopy were used for investigations. Results revealed that increasing crosslinker and surfactant contents and stirring rate leads to particle size reduction...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821098/physical-chemical-characteristics-and-potential-use-of-a-novel-alginate-zein-hydrogel-as-the-sorption-phase-for-polar-organic-compounds
#16
Natara D B Castilhos, Naiara M F M Sampaio, Bruno C da Silva, Izabel C Riegel-Vidotti, Marco T Grassi, Bruno J G Silva
A novel alginate based hydrogel was successfully prepared and tested for the solid phase microextraction of medium-to-high polarity compounds, when supported in a polypropylene (PP) fiber. Pure alginate when added onto the surface of the PP fiber, resulted in a significant improvement in the extraction efficiency of the analytes (except for β-estradiol). The alginate hydrogel was modified upon the incorporation of a small amount of zein, a corn protein. Interestingly, the alginate/zein-supported hydrogel was capable of successfully extracting compounds with low partition constant (Kow), such as 17-α-ethinyl estradiol, progesterone and estriol, since the initial water uptake decreased dramatically in this gel, therefore, leaving the alginate hydroxyl groups more available to interact with the polar compounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821093/urea-free-synthesis-of-chitin-based-acrylate-superabsorbent-polymers-under-homogeneous-conditions-effects-of-the-degree-of-deacetylation-and-the-molecular-weight
#17
T G Liu, Y T Wang, B Li, H B Deng, Z L Huang, L W Qian, X Wang
In order to understand the chemical structure of chitin-based acrylate superabsorbent polymers (SAP), chitin was dissolved in NaOH aqueous solution via freezing-thawing cyclic treatment without urea, subsequently, a transparent hydrogel was prepared by copolymerizing the alkali-chitin solution and acrylic acid directly. The effects of the degree of deacetylation (DDA) and the molecular weight (Mw) of chitin on the properties of SAP were investigated in detail. With increasing the DDA and Mw, the yield improved while the water absorbency decreased, yet the effect of DDA is insignificant if the Mw is smaller enough...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821071/on-the-use-of-ion-crosslinked-nanocellulose-hydrogels-for-wound-healing-solutions-physicochemical-properties-and-application-oriented-biocompatibility-studies
#18
Alex Basu, Jonas Lindh, Eva Ålander, Maria Strømme, Natalia Ferraz
Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented biocompatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material´s potential to maintain a suitable moist environment for different type of wounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821056/fabrication-of-salecan-poly-amps-co-hmaa-semi-ipn-hydrogels-for-cell-adhesion
#19
Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and has excellent physicochemical and biological properties. A series of hydrogels were fabricated from Salecan and poly(2-acrylamido-2-methylpropanesulfonic acid-co-N-hydroxymethyl acrylamide) (poly(AMPS-co-HMAA), PAH) by semi-IPN technique. The introduction of Salecan into the PAH network endows the system with enhanced cell adhesion properties. These semi-IPN hydrogels with open interconnected pores had pH and salt-sensitive swelling behavior. The increase in the content of hydrophilic Salecan could enhance the water uptake of the hydrogels...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821029/effect-of-gum-arabic-modified-alginate-on-physicochemical-properties-release-kinetics-and-storage-stability-of-liquid-core-hydrogel-beads
#20
Fu-Hsuan Tsai, Yutaka Kitamura, Mito Kokawa
Different weight ratios of alginate/gum arabic (GA) solutions were prepared to serve as the wall material of liquid-core hydrogel beads (LHB) that were formulated to protect the total phenolic compounds (TP) of radish by-product juice from degradation during storage and release in simulated gastrointestinal fluid. The diameter of LHB ranged from 4.63 to 5.66mm with a sphericity lower than 0.05. LHB formulated with 25% GA (AGB0.25) exhibited the highest hardness (26.63N), and those formulated with 50% GA (AGB0...
October 15, 2017: Carbohydrate Polymers
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