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Y R Zhang, K J Xu, Y L Bai, L Q Tang, Z Y Jiang, Y P Liu, Z J Liu, L C Zhou, X F Zhou
For high-water content hydrogels in compression, the water inside of hydrogels contributes to the response of hydrogels to external loads directly, but part of the water is expelled from hydrogels in the meantime to change the volume of the hydrogel and reduce the contribution. In order to consider the contribution of the water in the constitution equation, PVA (polyvinyl alcohol) hydrogels with high-water content were used as examples, and compressive experiments were carried out to measure both the stress-strain relation and the change of the volume in the meantime...
June 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Yan Huang, Jie Liu, Jiaqi Wang, Mengmeng Hu, Funian Mo, Guojin Liang, Chunyi Zhi
Self-healing solid-state aqueous rechargeable NiCo//Zn batteries are an essential element of flexible/wearable electronics due to their inherent safety, high energy density and mechanical robustness etc. However, the self-healability of solid-state batteries is only realized by few studies, in which electron/ion-inactive self-healable substrates are utilized. This fundamentally arises from the lack of self-healable electrolytes for solid-state batteries, and therefore, results in low healing efficiency and volume/mass diseconomy...
June 15, 2018: Angewandte Chemie
David Josh Cohen, Sharon L Hyzy, Salma Haque, Lucas C Olson, Barbara Boyan, Justin M Saul, Zvi Schwartz
Keratin proteins derived from human hair are known to contain a large number of cysteine residues. In hydrogels composed of oxidatively extracted keratin (keratose), sulfonic acid on the cysteine residues prevents disulfide crosslinking. Reductively extracted keratin (kerateine) has thiol groups on cysteine residues that can form disulfide crosslinks. The rates of keratin hydrogel erosion and, in some cases, drug release can be tuned by manipulating disulfide crosslinking levels via the keratose:kerateine (KOS:KTN) ratio...
June 15, 2018: Tissue Engineering. Part A
Teodora Gancheva, Nick Virgilio
This work demonstrates that a model system of poly( N-isopropylacrylamide) (PNIPAam) macroporous hydrogels, with tailored microstructures and comprising gold (Au) or silver (Ag) nanoparticles, display enhanced and tunable catalytic activity. These nanocomposites are prepared using polymer templates obtained from melt-processed cocontinuous polymer blends. The reaction rate, controlled by both hydrogel porosity and the PNIPAam lower critical solution temperature, increases by more than an order of magnitude as compared to nonporous gels, and is comparable to micro- or nanocarrier-based systems, with easier catalyst recovery...
June 15, 2018: ACS Applied Materials & Interfaces
Leopoldina D F Almeida, Pedro S Babo, Cristiana R Silva, Márcia T Rodrigues, Josimeri Hebling, Rui L Reis, Manuela E Gomes
The restoration of dentine-pulp complex remains a challenge for dentists; nonetheless, it has been poorly addressed. An ideal system should modulate the host response, as well as enable the recruitment, proliferation and differentiation of relevant progenitor cells. Herein was proposed a photocrosslinkable hydrogel system based on hyaluronic acid (HA) and platelet lysate (PL). PL is a cocktail of growth factors (GFs) and cytokines involved in wound healing orchestration, obtained by the cryogenic processing of platelet concentrates, and was expected to provide the HA hydrogels specific biochemical cues to enhance pulp cells' recruitment, proliferation and differentiation...
June 14, 2018: Journal of Materials Science. Materials in Medicine
Giulia Zampini, Luigi Tarpani, Giuseppina Massaro, Marta Gambucci, Eugenio Peli, Loredana Latterini
The use of plasmonic nanomaterials is a challenging strategy to control radiation and radiation-induced processes at a nanometric scale. The localized surface plasmons of metal nanoparticles have been shown to affect the efficiency of a variety of radiative and non-radiative processes occurring in organic molecules. In this contribution, we present an overview of the results obtained through an original approach based on the hierarchical assembly of plasmonic gold colloids on silica templates, covalently doped with organic dyes...
June 15, 2018: Photochemical & Photobiological Sciences
Kokkarachedu Varaprasad, Dariela Nunez, Murali Mohan Yallapu, Tippabattini Jayaramudu, Elizabeth Elgueta, Patricio Oyarzun
Herein, two kinds of nano-hydroxyapatite were synthesized from Clam and Magellan shell by wet chemical precipitation method. Mainly, carboxymethyl cellulose/acrylamide/nano-hydroxyapatite composite hydrogels were developed via a free-radical polymerization process and investigated as a sorbent for Acid Blue 113 (AB) from aqueous AB solution. The swelled and kinetic behaviours of hydrogels were investigated using a gravimetric method. The swelling properties of the CMC-AM-hydrogels were influenced by the calcium electrolytes (Ca2+ ) content in nano-hydroxyapatites...
May 16, 2018: RSC Advances
Benjamin A Minden-Birkenmaier, Gary L Bowlin
Over the past few decades, there has been a resurgence in the clinical use of honey as a topical wound treatment. A plethora of in vitro and in vivo evidence supports this resurgence, demonstrating that honey debrides wounds, kills bacteria, penetrates biofilm, lowers wound pH, reduces chronic inflammation, and promotes fibroblast infiltration, among other beneficial qualities. Given these results, it is clear that honey has a potential role in the field of tissue engineering and regeneration. Researchers have incorporated honey into tissue engineering templates, including electrospun meshes, cryogels, and hydrogels, with varying degrees of success...
June 14, 2018: Bioengineering
Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
In the present study, we reported the generation of a molecular hydrogel of succinated paclitaxel (PTX-SA) by a self-hydrolytic strategy for potential local cancer chemotherapy. Upon self-hydrolysis of the ester bond of PTX-SA in phosphate-buffered saline (pH = 7.4) for 24 h, a PTX-SA supramolecular hydrogel formed spontaneously with a minimal gelation concentration of 0.25 wt%. The formed PTX-SA supramolecular hydrogel displayed a filamentous nanostructure, the nanofibers of which were typically several micrometers in length with a diameter of 10-15 nm...
August 1, 2018: Journal of Biomedical Nanotechnology
Yi Deng, Guoqin Chen, Min Ye, Yingyan He, Zehua Li, Xianbao Wang, Caiwen Ou, Zhimou Yang, Minsheng Chen
Generally, nitric oxide (NO) is an important multi-functional cardioprotective soluble gas molecule. However, it may be detrimental when in excessive levels or combined with O2- a kind of reactive oxygen species (ROS)-to form ONOO-. The latter will rapidly decompose to highly reactive oxidant components. ROS will be abundantly produced during the ischemia/reperfusion (I/R) procedure. Therefore, an NO donor coupled with another antioxidant would be a more promising strategy for I/R treatment. In this study, we report on a novel self-assembly supramolecular hydrogel capable of constantly releasing both NO and curcumin (Cur) simultaneously, and we found that the combinational treatment of Cur and NO from the gel could efficiently reduce I/R injuries...
August 1, 2018: Journal of Biomedical Nanotechnology
Adriana Gilarska, Joanna Lewandowska-Łańcucka, Wojciech Horak, Maria Nowakowska
Studies on synthesis, physico-chemical and biological properties of novel biomimetic materials, potentially useful as injectable hydrogels are presented. These materials are in situ prepared chemically crosslinked collagen/chitosan/hyaluronic acid-based hydrogels exhibiting potential for tissue regeneration. Optimization of hydrogels involved testing the effect of various concentration of crosslinking agent (genipin) as well as different ratios of biopolymers used on their properties. The changes in the content of hyaluronic acid and in the genipin concentration used have been shown to be crucial...
June 4, 2018: Colloids and Surfaces. B, Biointerfaces
Xiaowei Hong, Ramkumar T Annamalai, Tyler S Kemerer, Cheri X Deng, Jan P Stegemann
Both static and time-dependent mechanical factors can have a profound impact on cell and tissue function, but it is challenging to measure the mechanical properties of soft materials at the scale which cells sense. Multimode ultrasound viscoelastography (MUVE) uses focused ultrasound pulses to both generate and image deformations within soft hydrogels non-invasively, at sub-millimeter resolution, and in 3D. The deformation and strain over time data are used to extract quantitative parameters that describe both the elastic and viscoelastic properties of the material...
June 2, 2018: Biomaterials
Daiki Nomura, Masaaki Saito, Yosuke Takahashi, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa
Self-gelling DNA hydrogels with cytosine-phosphate-guanine (CpG) motifs have been shown to exhibit high potency as vaccine adjuvants. However, their oral use is limited because of their thermodynamic and chemical instability in the gastrointestinal tract. In this study, we aimed to develop DNA hydrogel microspheres (Dgel-MS) coated with chitosan to improve their stability. Chitosan-coated Dgel-MS (Cs-Dgel-MS) was prepared by emulsifying Dgel to obtain the D-gel core, followed by mixing with microemulsions of chitosan for electrostatic coating...
June 11, 2018: International Journal of Pharmaceutics
Jianghua Li, Kaixi Zhang, Lin Ruan, Seow Fong Chin, Nirmani Wickramasinghe, Hanbin Liu, Vikashini Ravikumar, Jinghua Ren, Hongwei Duan, Liang Yang, Mary B Chan-Park
Biofilms and rapid evolution of multi-drug resistance complicate the treatment of bacterial infections. Antibiofilm agents such as metallic/inorganic nanoparticles or peptides act by exerting anti-bacterial effects and hence do not combat biofilms of antibiotics-resistant strains. In this paper we show that the block copolymer DA95B5, dextran-block-poly((3-acrylamidopropyl) trimethylammonium chloride (AMPTMA)-co-butyl methacrylate (BMA)), effectively removes preformed biofilms of various clinically relevant multi-drug resistant Gram-positive bacteria including Methicillin-resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci (VRE V583) and Enteroccocus faecalis (OG1RF)...
June 14, 2018: Nano Letters
Lokesh Karthik Narayanan, Trevor L Thompson, Rohan A Shirwaiker, Binil Starly
Biofabrication processes can affect biological quality attributes of encapsulated cells within constructs. Currently, assessment of the fabricated constructs is performed offline by subjecting the constructs to destructive assays that require staining and sectioning. This drawback limits the translation of biofabrication processes to industrial practice. In this work, we investigate the dielectric response of viable cells encapsulated in bioprinted 3D hydrogel constructs to an applied alternating electric field as a label-free non-destructive monitoring approach...
June 14, 2018: Biofabrication
Hui-Yi Hsiao, Chin-Yu Yang, Jia-Wei Liu, Eric M Brey, Ming-Huei Cheng
Periosteal osteogenic capacity can be exploited to enhance bone formation in the fields of tissue engineering and regenerative medicine. Despite this importance, there have been no studies examining the composition, structure and osteogenic capacity of periostea from different bone sources. In this study, structure and osteogenic factor content were compared among periostea from calvarial, rib, femoral and tibial bone, in which the native bones of these four regions were harvested and subjected to histological analysis...
June 14, 2018: Tissue Engineering. Part A
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Daisuke Aoki, Hiroharu Ajiro
In order to prepare thermoresponsive polyurethane gels, a novel polyurethane bearing oligo(ethylene glycol) (OEG) as the side chain is successfully synthesized with hexamethylene diisocyanate and OEG tartrate ester. The aqueous solution of the polyurethane shows sharp and clear lower critical solution temperature behavior at 34 °C. Furthermore, a hydrogel based on the same polyurethane is also successfully prepared using glycerol as the crosslinker. This polyurethane hydrogel including 10 mol% of glycerol presents a large swelling ratio change between 4 °C and 37 °C from 250% to 40%...
June 13, 2018: Macromolecular Rapid Communications
Eliza Li Shan Fong, Tan Boon Toh, Quy Xiao Xuan Lin, Zheng Liu, Lissa Hooi, Masturah Bte Mohd Abdul Rashid, Touati Benoukraf, Edward Kai-Hua Chow, The Hung Huynh, Hanry Yu
This data article presents datasets associated with the research article entitled "Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer" (Fong et al., 2018) [1]. A three-dimensional macroporous sponge system was used to generate in vitro counterparts to various hepatocellular carcinoma patient-derived xenograft (HCC-PDX) lines. This article describes the viability, proliferative capacity and molecular features (genomic and transcriptomic profiles) of the cultured HCC-PDX cells...
June 2018: Data in Brief
Kazuya Matsumoto, Nobuki Sakikawa, Takashi Miyata
The water content of thermo-responsive hydrogels can be drastically altered by small changes in temperature because their polymer chains change from hydrophilic to hydrophobic above their low critical solution temperature (LCST). In general, such smart hydrogels have been utilized in aqueous solutions or in their wet state, and no attempt has been made to determine the phase-transition behavior of the gels in their dried states. Here we demonstrate an application of the thermo-responsive behavior of an interpenetrating polymer network (IPN) gel comprising thermo-responsive poly(N-isopropylacrylamide) and hydrophilic sodium alginate networks in their dried states...
June 13, 2018: Nature Communications
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