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Autoimmune nutrition

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https://www.readbyqxmd.com/read/27871350/early-description-of-diet-induced-blistering-skin-diseases-in-medieval-persia-avicenna-s-point-of-view
#1
Fatemeh Atarzadeh, Babak Daneshfard, Ladan Dastgheib, Amir-Mohammad Jaladat, Gholamreza Amin
Pemphigus is an autoimmune blistering skin disease that is strongly associated with different environmental factors. Among these, nutritional factors are considered to trigger pemphigus; however, their role may be underestimated. Investigated more recently in conventional medicine, this causative bond between dietary factors and blistering skin diseases was mentioned by Persian scholars such as Avicenna a thousand years ago. Avicenna, a well-known Persian physician and philosopher, who could be considered a pioneer in dermatology, discussed skin diseases in a chapter in The Canon of Medicine...
2016: Skinmed
https://www.readbyqxmd.com/read/27855237/insulin-autoimmune-syndrome-a-rare-cause-of-postprandial-hypoglycemia
#2
Pooja Sahni, Nitin Trivedi, Abdulkadir Omer
: A 65-year-old obese Caucasian woman presented with symptomatic postprandial hypoglycemic episodes, resolution of symptoms with carbohydrate intake and significantly elevated anti-insulin antibody levels. She did not have any evidence for the use of oral antidiabetic medications, insulin, herbal substances, performing strenuous exercise or history of bariatric surgery. Fingerstick blood glucose readings revealed blood sugar of 35 mg/dL and 48 mg/dL, when she had these symptoms. Her medical history was significant for morbid obesity, hypothyroidism and gastro esophageal reflux disease...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27815799/cla-has-a-useful-effect-on-bone-markers-in-patients-with-rheumatoid-arthritis
#3
N Aryaeian, F Shahram, M Djalali
: Rheumatoid arthritis is a systemic, chronic disease which may increase the risk of osteoporosis. This study was carried out in order to examine the effect of conjugated linoleic acid (CLA) on bone markers in rheumatoid arthritis disease which is the most common autoimmune disease. The present study is a randomized double-blind clinical trial. Subjects included 52 patients with active rheumatoid arthritis who were divided into two groups. Group I received standard treatment plus 2 daily 1...
November 4, 2016: Lipids
https://www.readbyqxmd.com/read/27799014/effect-of-marijuana-use-on-thyroid-function-and-autoimmunity
#4
Sonali Malhotra, Rubina A Heptulla, Peter Homel, Roja Motaghedi
BACKGROUND: Marijuana is legalized for medical use in 24 states and for recreational use in 5. However, effects of marijuana use on thyroid function and autoimmunity are unknown. METHODS: We performed a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012 to assess the effects of marijuana on thyroid function and autoimmunity in users. We included 5280 adults ages 18 to 69 years, who responded to questions related to marijuana use and had laboratory results related to thyroid parameters...
December 5, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27783083/extra-virgin-olive-oil-a-key-functional-food-for-prevention-of-immune-inflammatory-diseases
#5
REVIEW
Marina Aparicio-Soto, Marina Sánchez-Hidalgo, Ma Ángeles Rosillo, Ma Luisa Castejón, Catalina Alarcón-de-la-Lastra
Nowadays, it is clear that an unhealthy diet is one of the prime factors that contributes to the rise of inflammatory diseases and autoimmunity in the populations of both developed and developing countries. The Mediterranean diet has been associated with a reduced incidence of certain pathologies related to chronic inflammation and the immune system. Olive oil, the principal source of dietary lipids of the Mediterranean diet, possesses a high nutritional quality and a particular composition, which is especially relevant in the case of Extra Virgin Olive Oil (EVOO)...
October 26, 2016: Food & Function
https://www.readbyqxmd.com/read/27714440/celiac-disease-is-associated-with-reduced-bone-mineral-density-and-increased-frax-scores-in-the-us-national-health-and-nutrition-examination-survey
#6
E Kamycheva, T Goto, C A Camargo
: We investigated the association between celiac disease (CD) and bone mass density (BMD) and risk of osteoporotic fractures in the general US population. In children and men ≥18 years, CD was associated with reduced BMD, and in men ≥40 years, CD was associated with increased risk of osteoporotic fractures. INTRODUCTION: Celiac disease (CD) is an autoimmune condition, characterized by inflammation of the small intestine. CD has an increasing prevalence, and if unrecognized or untreated, CD can lead to complications from malabsorption and micronutrient deficiencies...
October 6, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27684858/low-serum-albumin-concentrations-are-associated-with-disease-severity-in-patients-with-myasthenia-gravis
#7
Yi-Yun Weng, De-Hao Yang, Mei-Zi Qian, Mao-Mao Wei, Fang Yin, Jia Li, Xiang Li, Ying Chen, Zhang-Na Ding, Yi-Bo He, Xu Zhang
Serum albumin (S-Alb) is a widely used biomarker of nutritional status and disease severity in patients with autoimmune diseases. We investigated the correlation between S-Alb and the severity of myasthenia gravis (MG).A total number of 166 subjects were recruited in the study. Subjects were divided into 3 groups (T1 to T3) by S-Alb levels: T1: 21.1 to 38.4 g/L, T2: 38.5 to 41.5 g/L, T3: 41.6 to 48.9 g/L. Regression analysis was performed to determine the correlation of initial albumin concentrations and the severity of disease of MG...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27667580/insights-into-the-pathogenesis-of-mycoplasma-pneumoniae-review
#8
Jun He, Mihua Liu, Zhufeng Ye, Tianping Tan, Xinghui Liu, Xiaoxing You, Yanhua Zeng, Yimou Wu
Mycoplasma are the smallest prokaryotic microbes present in nature. These wall‑less, malleable organisms can pass through cell filters, and grow and propagate under cell‑free conditions in vitro. Of the pathogenic Mycoplasma Mycoplasma pneumoniae has been examined the most. In addition to primary atypical pneumonia and community‑acquired pneumonia with predominantly respiratory symptoms, M. pneumoniae can also induce autoimmune hemolytic anemia and other diseases in the blood, cardiovascular system, gastrointestinal tract and skin, and can induce pericarditis, myocarditis, nephritis and meningitis...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27639869/type-1-diabetes-in-sardinia-facts-and-hypotheses-in-the-context-of-worldwide-epidemiological-data
#9
M Songini, C Mannu, C Targhetta, G Bruno
Type 1 diabetes (T1D) results from an autoimmune destruction of insulin-producing beta cells that requires lifelong insulin treatment. While significant advances have been achieved in treatment, prevention of complications and quality of life in diabetic people, the identification of environmental triggers of the disease is far more complex. The island of Sardinia has the second highest incidence of T1D in the world (45/100,000), right after Finland (64.2/100,000). The genetic background as well as the environment of the island's inhabitants makes it an ideal region for investigating environmental, immunological and genetic factors related to the etiopathogenesis of T1D...
September 17, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27630012/periodontal-and-other-oral-manifestations-of-immunodeficiency-diseases
#10
M E Peacock, R M Arce, C W Cutler
The list of immunodeficiency diseases grows each year as novel disorders are discovered, classified, and sometimes reclassified due to our ever-increasing knowledge of immune system function. Although the number of patients with secondary immunodeficiencies (SIDs) greatly exceeds those with primary immunodeficiencies (PIDs), the prevalence of both appears to be on the rise probably because of scientific breakthroughs that facilitate earlier and more accurate diagnosis. Primary immunodeficiencies in adults are not as rare as once thought...
September 15, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27623983/association-of-serum-25-hydroxyvitamin-d-concentration-with-hla-b-drb1-and-dqb1-genetic-polymorphisms
#11
M E Miettinen, L Kinnunen, V Harjutsalo, K Aimonen, H-M Surcel, C Lamberg-Allardt, J Tuomilehto
BACKGROUND/OBJECTIVES: The human leukocyte antigen (HLA) gene region associates with the risk for several autoimmune diseases, including type 1 diabetes. An association between vitamin D deficiency and several autoimmune diseases has been suggested. We tested the association between serum 25-hydroxyvitamin D (25OHD) concentrations and HLA alleles in pregnant Finnish women. SUBJECTS/METHODS: HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children)...
September 14, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#12
EDITORIAL
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27552783/the-place-of-nailfold-capillaroscopy-among-instrumental-methods-for-assessment-of-some-peripheral-ischaemic-syndromes-in-rheumatology
#13
Sevdalina N Lambova
Micro- and macrovascular pathology is a frequent finding in a number of common rheumatic diseases. Secondary Raynaud's phenomenon (RP) is among the most common symptoms in systemic sclerosis and several other systemic autoimmune diseases including a broad differential diagnosis. It should be also differential from other peripheral vascular syndromes such as embolism, thrombosis, etc., some of which lead to clinical manifestation of the blue toe syndrome. The current review discusses the instrumental methods for vascular assessments...
April 2016: Folia Medica
https://www.readbyqxmd.com/read/27543618/association-between-vitamin-d-deficiency-and-antinuclear-antibodies-in-middle-aged-and-older-u-s-adults
#14
Helen C S Meier, Dale P Sandler, Eleanor M Simonsick, Christine G Parks
BACKGROUND: Vitamin D deficiency is associated with cancer and autoimmune diseases, but little is known about the association between vitamin D and antinuclear antibodies (ANA), a biomarker of immune dysfunction in healthy populations. The objective of this study was to determine whether vitamin D deficiency is associated with ANA in middle-aged and older U.S. adults. METHODS: A cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) 2001-2004 was conducted...
December 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27538982/vitamin-d-and-the-pathogenesis-of-inflammatory-bowel-disease
#15
REVIEW
Berkeley N Limketkai, Matthew L Bechtold, Douglas L Nguyen
Vitamin D has traditionally been known for its role in bone metabolism, but emerging evidence has suggested a broader role for vitamin D in immune regulation. Vitamin D deficiency has been associated with the pathogenesis of diverse autoimmune disorders and has similarly been implicated as a contributor to inflammatory bowel disease. In this review, we discuss animal, in vitro, genetic, and epidemiologic studies that have linked vitamin D deficiency with inflammatory bowel disease pathogenesis or severity. Nonetheless, we present the caveat in interpreting these studies in the context of reverse causation: Does vitamin D deficiency lead to gastrointestinal disease, or does gastrointestinal disease (with related changes in dietary choices, intestinal absorption, nutritional status, lifestyle) lead to vitamin D deficiency?...
October 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27471608/anti-tnf-refractory-colitis-after-checkpoint-inhibitor-therapy-possible-role-of-cmv-mediated-immunopathogenesis
#16
Katharina Lankes, Gheorghe Hundorfean, Thomas Harrer, Ansgar J Pommer, Abbas Agaimy, Irena Angelovska, Azadeh Tajmir-Riahi, Jonas Göhl, Gerold Schuler, Markus F Neurath, Werner Hohenberger, Lucie Heinzerling
Immune-related adverse events (irAEs) induced by checkpoint inhibitors are well known. Since fatal outcomes have been reported early detection and adequate management are crucial. In particular, colitis is frequently observed and can result in intestinal perforation. This is the first report of an autoimmune colitis that was treated according to algorithms but became resistant due to a CMV reactivation. The 32-y-old male patient with metastatic melanoma treated within an anti-PD-1/ipilimumab combination study developed severe immune-mediated colitis (CTCAE grade 3) with up to 18 watery stools per day starting 2 weeks after treatment initiation...
June 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27424223/role-of-lipids-in-the-metabolism-and-activation-of-immune-cells
#17
REVIEW
Merla J Hubler, Arion J Kennedy
Immune cell plasticity has extensive implications in the pathogenesis and resolution of metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders. Over the past decade, nutritional status has been discovered to influence the immune response. In metabolic disorders such as obesity, immune cells interact with various classes of lipids, which are capable of controlling the plasticity of macrophages and T lymphocytes. The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on two areas: (1) the impact of altering lipid metabolism on immune cell activation, differentiation and function and (2) the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity...
August 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27396525/the-critical-role-of-epigenetics-in-systemic-lupus-erythematosus-and-autoimmunity
#18
Hai Long, Heng Yin, Ling Wang, M Eric Gershwin, Qianjin Lu
One of the major disappointments in human autoimmunity has been the relative failure on genome-wide association studies to provide "smoking genetic guns" that would explain the critical role of genetic susceptibility to loss of tolerance. It is well known that autoimmunity refers to the abnormal state that the dysregulated immune system attacks the healthy cells and tissues due to the loss of immunological tolerance to self-antigens. Its clinical outcomes are generally characterized by the presence of autoreactive immune cells and (or) the development of autoantibodies, leading to various types of autoimmune disorders...
November 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27373325/current-concepts-in-chronic-inflammatory-diseases-interactions-between-microbes-cellular-metabolism-and-inflammation
#19
Holger Garn, Sabine Bahn, Bernhard T Baune, Elisabeth B Binder, Hans Bisgaard, Talal A Chatila, Triantafyllos Chavakis, Carsten Culmsee, Udo Dannlowski, Steffen Gay, James Gern, Tari Haahtela, Tilo Kircher, Ulf Müller-Ladner, Markus F Neurath, Klaus T Preissner, Christoph Reinhardt, Graham Rook, Shannon Russell, Bernd Schmeck, Thaddeus Stappenbeck, Ulrich Steinhoff, Jim van Os, Scott Weiss, Michael Zemlin, Harald Renz
Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Röntgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress...
July 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27347013/importance-of-gut-microbiota-in-health-and-diseases-of-new-born-infants
#20
Jisheng Gao, Hongwei Wu, Jinfeng Liu
The multifarious assortment of microorganisms present in gut of humans is termed as gut microbiota. These include 1,000 species accompanied by approximately 2 million genes in an individual adult. The gut microbiota has multifactorial protective roles against allergic reactions, inflammation, cardiac pathological states and even in the state of malignant carcinogenesis existing in humans. By contrast, adverse alterations in the microbiota result in chronic pathological states, including autoimmune diseases, cancer and circulatory system obstructions...
July 2016: Experimental and Therapeutic Medicine
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