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https://www.readbyqxmd.com/read/28441368/skeletal-scintigraphy
#1
Jaime L Montilla-Soler, Rikesh Makanji
BACKGROUND: Skeletal scintigraphy remains a valuable tool in the initial and subsequent evaluation of the skeletal system in patients with a diagnosis of primary or metastatic neoplasms. METHODS: We discuss radiopharmaceuticals, nuclear medicine imaging techniques, and current as well as future oncological applications in the adult population. Pertinent literature was reviewed to describe the advantages and limitations of available technologies for the evaluation of skeletal metastatic disease...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28439237/biomarkers-of-osteosarcoma-chondrosarcoma-and-ewing-sarcoma
#2
REVIEW
Francesco R Evola, Luciano Costarella, Vito Pavone, Giuseppe Caff, Luca Cannavò, Andrea Sessa, Sergio Avondo, Giuseppe Sessa
Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28417853/the-role-of-18-f-fdg-pet-ct-in-pediatric-sarcoma
#3
REVIEW
Douglas J Harrison, Marguerite T Parisi, Barry L Shulkin
Considerable debate remains regarding how best to incorporate (18)F-FDG-PET/CT into clinical practice for pediatric sarcomas. Although there is a clear role for (18)F-FDG-PET/CT in staging pediatric sarcoma, the value of (18)F-FDG-PET/CT in prognostication for pediatric sarcomas remains unclear. In osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma, (18)F-FDG-PET/CT may be most useful in the identification of skeletal metastases, where the literature consistently suggests that it has improved sensitivity and specificity as compared to bone scintigraphy...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28415638/altered-long-non-coding-rnas-predict-worse-outcome-in-osteosarcoma-patients-evidence-from-a-meta-analysis
#4
Yanliang Yang, Shunli Wang, Teng Li
Long non-coding RNAs (lncRNAs) are emerging as promising prognostic biomarkers in an expanding list of malignant neoplasms. Here, we sought to investigate the strength of associations between lncRNA signatures and clinical outcomes in osteosarcoma. We conducted a systematic search of the online databases from inception to July 2016. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for the primary endpoints of overall survival (OS), progression-free survival (PFS) or event-free survival (EFS) were extracted and meta-analyzed...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415557/long-non-coding-rna-cta-sensitizes-osteosarcoma-cells-to-doxorubicin-through-inhibition-of-autophagy
#5
Zhengguang Wang, Zhendong Liu, Song Wu
Recently, several long non-coding RNAs (lncRNAs) have been implicated in osteosarcoma (OS). However, the regulatory roles of lncRNAs in chemotherapy resistance of OS still remain unclear. This study aimed to screen a novel lncRNA that contributes to chemotherapeutic resistance of OS, and to explore the underlying mechanisms. Our data showed that lncRNA CTA was markedly downregulated in OS tissues compared to their matched non-tumor tissues, and low expression of lncRNA CTA was significantly associated with the advanced clinical stage and tumor size...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409896/childhood-osteosarcoma-incidence-and-survival-in-argentina-report-from-the-national-pediatric-cancer-registry-roha-network-2000-2013
#6
F Moreno, W Cacciavillano, M Cipolla, M Coirini, P Streitenberger, J López Martí, M Palladino, M Morici, M Onoratelli, G Drago, A Schifino, M Cores, A Rose, J Jotomliansky, M Varel, M García Lombardi
BACKGROUND: Differences in incidence and survival in osteosarcoma reports are considerable worldwide. PURPOSE: This study describes the incidence and survival of patients with osteosarcoma in Argentina with data from the National Pediatric Cancer Registry (ROHA), and the impact of age, gender, stage, regional, and socioeconomic indicators on outcome. METHODS: Pediatric patients with osteosarcoma reported to ROHA from 2000 through 2013 were analyzed, the annual age-standardized incidence rate (ASR) was calculated using the National Vital Statistics, and survival was estimated...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28384168/lack-of-association-between-platelet-indices-and-disease-stage-in-osteosarcoma-at-diagnosis
#7
Hongtao Li, Yonggang Wang, Zimei Liu, Yuan Yuan, Wentao Huang, Na Zhang, Aina He, Zan Shen, Yuanjue Sun, Yang Yao
PURPOSE: The purpose of this study was to investigate the relationship between platelet indices [mean platelet volume (MPV), platelet count (PLT), platelet distribution width (PDW) and plateletcrit (PCT)] at diagnosis in osteosarcoma. METHODS: The information of 233 patients with osteosarcoma at diagnosis between 2007 and 2015 was retrospectively reviewed. Clinical parameters such as gender, age, size and site of tumor, and tumor necrosis rate after neoadjuvant chemotherapy were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28381518/microrna-379-inhibits-the-proliferation-migration-and-invasion-of-human-osteosarcoma-cells-by-targeting-eif4g2
#8
Xi Xie, Yu-Sheng Li, Wen-Feng Xiao, Zhen-Han Deng, Hong-Bo He, Qing Liu, Wei Luo
Osteosarcoma (OS) is an aggressive malignant mesenchymal neoplasm among adolescents. The aim of this study was to explore the various modes of action microRNA-379 (miR-379) has on the proliferation, migration and invasion of human OS cells. MiR-379 achieves this by targeting EIF4G2. Human OS cell lines U2OS and MG-63 were selected, and assigned into a blank, miR-379 mimics, miR-379 mimic negative control (NC), miR-379 inhibitors, miR-379 inhibitor NC, EIF4G2 shRNA, control shRNA and miR-379 inhibitor + EIF4G2 shRNA group...
April 5, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28358629/reconstruction-of-a-mandibular-segmental-defect-with-a-customized-3-dimensional-printed-titanium-prosthesis-in-a-cat-with-a-mandibular-osteosarcoma
#9
Julius M Liptak, Graham P Thatcher, Jonathan P Bray
CASE DESCRIPTION A 12-year-old neutered male domestic shorthair cat had been treated for a mass arising from the lingual aspect of the caudal right mandibular body. Cytoreductive surgery of the mass had been performed twice over a 2-year period, but the mass recurred following both surgeries. The mass was diagnosed as an osteosarcoma, and the cat was referred for further evaluation and treatment. CLINICAL FINDINGS Clinical findings were unremarkable, except for a 2-cm-diameter mass arising from the lingual aspect of the right mandible and mild anemia and lymphopenia...
April 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28356114/effectiveness-of-multi-drug-regimen-chemotherapy-treatment-in-osteosarcoma-patients-a-network-meta-analysis-of-randomized-controlled-trials
#10
Xiaojie Wang, Hong Zheng, Tao Shou, Chunming Tang, Kun Miao, Ping Wang
BACKGROUND: Osteosarcoma is the most common malignant bone tumour. Due to the high metastasis rate and drug resistance of this disease, multi-drug regimens are necessary to control tumour cells at various stages of the cell cycle, eliminate local or distant micrometastases, and reduce the emergence of drug-resistant cells. Many adjuvant chemotherapy protocols have shown different efficacies and controversial results. Therefore, we classified the types of drugs used for adjuvant chemotherapy and evaluated the differences between single- and multi-drug chemotherapy regimens using network meta-analysis...
March 29, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28350098/slc3a2-is-upregulated-in-human-osteosarcoma-and-promotes-tumor-growth-through-the-pi3k-akt-signaling-pathway
#11
Bin Zhu, Dongdong Cheng, Lei Hou, Shumin Zhou, Tao Ying, Qingcheng Yang
Growing evidence indicates that SLC3A2 (solute carrier family 3 member 2) is upregulated and correlates with tumor growth in multiple types of cancers, while the role of SLC3A2 in human osteosarcoma (OS) is rarely discussed. Thus, the aim of the present study was to demonstrate the expression of SLC3A2 in human osteosarcoma and reveal its biological function and the underlying mechanisms. RT-PCR, western blot analysis and immunohistochemistry (IHC) were used to assess the expression of SLC3A2 in OS samples and cell lines...
March 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28280610/investigation-of-the-human-h3-3b-h3f3b-gene-expression-as-a-novel-marker-in-patients-with-colorectal-cancer
#12
Habib Allah Ayoubi, Frouzandeh Mahjoubi, Rezvan Mirzaei
BACKGROUND: H3.3 histone is a replacement histone subtype that is express in entire cell cycle phases and overexpress in transcriptionally active regions, promoter regions, and intergenic or intragenic regulatory elements. This histone encoded by two genes termed H3.3A (H3F3A) and H3.3B (H3F3B). Mutations of these two genes lead to some human cancers such as chondroblastoma, osteosarcoma, and epithelial ovarian cancer. The aims of this study were to quantitatively examine the expression of H3...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28277189/cxcl5-plays-a-promoting-role-in-osteosarcoma-cell-migration-and-invasion-in-autocrine-and-paracrine-dependent-manners
#13
Hongsheng Dang, Wuzhou Wu, Bo Wang, Cao Cui, Juwei Niu, Jie Chen, Ziqiu Chen, Yi Liu
CXCL5, a CXC-type chemokine, is an important attractant for granulocytic immune cells by binding to its receptor CXCR2. Recently, CXCL5/CXCR2 has been found to play an oncogenic role in many human cancers. However, the exact role of CXCL5 in osteosarcoma cell migration and invasion has not been revealed. Here we found that the protein expression of CXCL5 was significantly increased in osteosarcoma tissues compared with that in matched adjacent nontumor tissues. Moreover, the expression of CXCL5 was significantly associated with advanced clinical stage and metastasis...
January 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28272712/the-expression-and-function-of-mirna-106-in-pediatric-osteosarcoma
#14
M Xu, Y-Y Zhang, H-F Wang, G-S Yang
OBJECTIVE: This study is to investigate the expression and biological function of miRNA-106b in osteosarcoma. PATIENTS AND METHODS: Freshly resected osteosarcoma tissues and the corresponding para-carcinoma tissues were collected from 54 patients. Then miR-106b level in the carcinoma tissues was detected by real-time PCR. To test the function of miR-106b, osteosarcoma cell line U2-OS was transfected with miR-106b inhibitor in vitro. Then, the proliferation, cell cycle, invasion and metastasis of U2-OS cells were detected by CCK-8 assay, flow cytometry, and transwell respectively...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28260104/mir-92a-promotes-tumor-growth-of-osteosarcoma-by-targeting-pten-akt-signaling-pathway
#15
Jie Xiao, Weifeng Yu, Kongzu Hu, Maoqiang Li, Jianwei Chen, Zhanchun Li
MicroRNAs (miRNAs) play critical roles in human cancers including osteosarcoma (OS). miR-92a has been found to be a cancer-related miRNA in many cancer types and it is upregulated in OS cell lines. However, the expression and biological function of miR-92a in OS have not been investigated. In this study, we showed that miR-92a expression was increased in OS tissues, and its high expression was correlated with clinical stage, T classification and histological differentiation. Furthermore, patients with high expression of miR-92a had a significantly poorer survival rate...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28260090/actin-like-protein-6a-is-a-novel-prognostic-indicator-promoting-invasion-and-metastasis-in-osteosarcoma
#16
Wei Sun, Wanchun Wang, Jian Lei, Hui Li, Yi Wu
Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysis of frozen fresh primary tumor tissues, matched non-cancerous bone tissues (NCBTs) and biopsy lung metastatic nodule tissues from 30 osteosarcoma patients after radical surgical resection, ACTL6A was overexpressed in osteosarcoma tissues compared with matched NCBTs, and its expression level was associated with osteosarcoma metastasis...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28249982/staged-lengthening-and-reconstruction-for-children-with-a-leg-length-discrepancy-after-excision-of-an-osteosarcoma-around-the-knee
#17
S Kang, J S Lee, J Park, S-S Park
AIMS: Children treated for osteosarcoma around the knee often have a substantial leg-length discrepancy at skeletal maturity. The aim of this study was to investigate the results of staged skeletal reconstruction after a leg lengthening procedure using an external fixator in these patients. PATIENTS AND METHODS: We reviewed 11 patients who underwent staged reconstruction with either an arthroplasty (n = 6) or an arthrodesis (n = 5). A control group of 11 patients who had undergone wide excision and concurrent reconstruction with an arthroplasty were matched for gender, location, and size of tumour...
March 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28244849/microrna-373-promotes-growth-and-cellular-invasion-in-osteosarcoma-cells-by-activation-of-pi3k-akt-rac1-jnk-pathway-the-potential-role-in-spinal-osteosarcoma
#18
Yufeng Liu, Zhengliang Cheng, Feng Pan, Weigang Yan
Spinal osteosarcoma (OS) has been proved more difficult to treat owing to potently malignant metastasis. The present study was aimed to explore functional role of microRNA (miR)-373 in cell growth and cellular invasion of OS cells, as well as its underlying mechanism. Expressions of miR-373 were analyzed in spinal OS tissues and cell lines. MG-63 cells were transfected with miR-373 mimic or inhibitor and/or treated with the inhibitor of phosphoinositide 3-kinase (PI3K) (LY294002) or the inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac) guanosine triphosphate (GTPase) (NSC23766), and then the of miR-373 aberrant expression on cell growth and cellular invasion were measured, along with the impacts of overexpressing miR-373 on expression of p53 and PI3K/AKT pathway related proteins...
December 15, 2016: Oncology Research
https://www.readbyqxmd.com/read/28239821/analysis-of-circulating-long-non-coding-rna-uca1-as-potential-biomarkers-for-diagnosis-and-prognosis-of-osteosarcoma
#19
J-J Wen, Y-D Ma, G-S Yang, G-M Wang
OBJECTIVE: The aim of this investigation was to examine the potential usefulness of long non-coding RNA UCA1 (UCA1) as a biomarker for diagnosis and prognosis in osteosarcoma. PATIENTS AND METHODS: The expression level of UCA1 was determined using TaqMan real-time PCR in human osteosarcoma tissues and patients' sera. Next, we investigated to clarify the relationship of UCA1 with clinicopathological features. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of UCA1...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28224623/outcome-and-prognostic-factors-following-curative-intent-surgery-for-oral-tumours-in-dogs-234-cases-2004-to-2014
#20
B N Sarowitz, G J Davis, S Kim
OBJECTIVES: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs. METHODS: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction...
February 22, 2017: Journal of Small Animal Practice
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