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https://www.readbyqxmd.com/read/28537682/elevated-ndc80-expression-is-associated-with-poor-prognosis-in-osteosarcoma-patients
#1
B Xu, D-P Wu, R-T Xie, L-G Liu, X-B Yan
OBJECTIVE: Osteosarcoma (OS) is a commonly diagnosed bone malignancy in children and adolescents. Nuclear division cycle 80 (NDC80) is a crucial regulator of the cell division cycle that has recently been identified as a novel oncoprotein in various solid tumors; however, its role in OS remains poorly understood. The aim of this study was to investigate correlations between NDC80 expression in OS patients and clinicopathological features and prognosis. PATIENTS AND METHODS: We began this study by determining NDC80 expression in sarcoma patients using the Oncomine Platform...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28521412/microrna-335-and-its-target-rock1-synergistically-influence-tumor-progression-and-prognosis-in-osteosarcoma
#2
Yong Wang, Ningning Wang, Xiandong Zeng, Jie Sun, Guangbin Wang, Huimian Xu, Wei Zhao
MicroRNA (miR)-335 and Rho-associated serine-threonine protein kinase 1 (Rock1) is ectopically expressed in multiple malignant tumors including osteosarcoma. The present study aimed to clarify whether the combined ectopically expressed miR-335 and Rock1 was correlated with clinicopathological features and prognosis in patients with osteosarcoma. The expression of miR-335 and Rock1 in 91 osteosarcoma tissue samples and 47 noncancerous bone tissues were determined respectively by in situ hybridization and immunohistochemistry...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521394/increased-six1-expression-is-associated-with-poor-prognosis-in-patients-with-osteosarcoma
#3
Lemeng Chao, Jianfeng Liu, Dewei Zhao
Sine oculis homeobox homolog 1 (Six1) is an evolutionarily conserved transcription factor that acts as master regulator of development and is frequently dysregulated in various types of cancer. Six1 has been demonstrated to be upregulated in human osteosarcoma cell lines compared with osteoblastic cell lines. However, the association of Six1 expression with the progression and prognosis of osteosarcoma patients remains unclear. The purpose of the present study was to investigate the association between Six1 expression and the clinicopathological characteristics and prognosis of osteosarcoma...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28506242/an-imprinted-non-coding-genomic-cluster-at-14q32-defines-clinically-relevant-molecular-subtypes-in-osteosarcoma-across-multiple-independent-datasets
#4
Katherine E Hill, Andrew D Kelly, Marieke L Kuijjer, William Barry, Ahmed Rattani, Cassandra C Garbutt, Haydn Kissick, Katherine Janeway, Antonio Perez-Atayde, Jeffrey Goldsmith, Mark C Gebhardt, Mohamed S Arredouani, Greg Cote, Francis Hornicek, Edwin Choy, Zhenfeng Duan, John Quackenbush, Benjamin Haibe-Kains, Dimitrios Spentzos
BACKGROUND: A microRNA (miRNA) collection on the imprinted 14q32 MEG3 region has been associated with outcome in osteosarcoma. We assessed the clinical utility of this miRNA set and their association with methylation status. METHODS: We integrated coding and non-coding RNA data from three independent annotated clinical osteosarcoma cohorts (n = 65, n = 27, and n = 25) and miRNA and methylation data from one in vitro (19 cell lines) and one clinical (NCI Therapeutically Applicable Research to Generate Effective Treatments (TARGET) osteosarcoma dataset, n = 80) dataset...
May 15, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28506183/strategies-and-challenges-for-communicating-the-diagnosis-of-cancer-in-cross-cultural-clinical-settings-perspectives-from-south-african-healthcare-professionals
#5
Ottilia Brown, Veonna Goliath, Dalena R M van Rooyen, Colleen Aldous, Leonard Charles Marais
Communicating the diagnosis of cancer in cross-cultural clinical settings is a complex task. This qualitative research article describes the content and process of informing Zulu patients in South Africa of the diagnosis of cancer, using osteosarcoma as the index diagnosis. We used a descriptive research design with census sampling and focus group interviews. We used an iterative thematic data analysis process and Guba's model of trustworthiness to ensure scientific rigour. Our results reinforced the use of well-accepted strategies for communicating the diagnosis of cancer...
May 16, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28496199/upregulation-and-biological-function-of-transmembrane-protein-119-in-osteosarcoma
#6
Zhen-Huan Jiang, Jun Peng, Hui-Lin Yang, Xing-Li Fu, Jin-Zhi Wang, Lei Liu, Jian-Nong Jiang, Yong-Fei Tan, Zhi-Jun Ge
Osteosarcoma is suggested to be caused by genetic and molecular alterations that disrupt osteoblast differentiation. Recent studies have reported that transmembrane protein 119 (TMEM119) contributes to osteoblast differentiation and bone development. However, the level of TMEM119 expression and its roles in osteosarcoma have not yet been elucidated. In the present study, TMEM119 mRNA and protein expression was found to be up-regulated in osteosarcoma compared with normal bone cyst tissues. The level of TMEM119 protein expression was strongly associated with tumor size, clinical stage, distant metastasis and overall survival time...
May 12, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28477425/outcome-and-complications-in-dogs-with-appendicular-primary-bone-tumors-treated-with-stereotactic-radiotherapy-and-concurrent-surgical-stabilization
#7
Sarah E Boston, Arathi Vinayak, Xiaomin Lu, Susan Larue, Nicholas J Bacon, Jason A Bleedorn, Carlos H M Souza, Nicole P Ehrhart
OBJECTIVE: To document the outcome of dogs with appendicular primary bone tumors treated with stereotactic radiotherapy (SRT) and concurrent stabilization. STUDY DESIGN: Multi-institutional retrospective case series. ANIMALS: Eighteen dogs with presumptive or definitive diagnosis of appendicular osteosarcoma. METHODS: Medical records of dogs with appendicular primary bone tumors treated with SRT and stabilization were reviewed for signalment, preoperative staging and diagnostics, radiation dose, stabilization method, and outcome...
May 6, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28476039/nano-pulse-stimulation-nps-ablates-tumors-and-inhibits-lung-metastasis-on-both-canine-spontaneous-osteosarcoma-and-murine-transplanted-hepatocellular-carcinoma-with-high-metastatic-potential
#8
Xinhua Chen, Yiling Chen, Jianwen Jiang, Liming Wu, Shengyong Yin, Xudong Miao, R James Swanson, Shusen Zheng
BACKGROUND: Nanosecond pulsed electric field (nsPEF), which is also termed as nano-pulse stimulation (NPS), has the potential of stimulating immune responses toward cancer cells. The current study investigates its local and systemic antitumor efficacy in vivo in late stage tumors with lung metastasis. METHOD: The 12 canines with spontaneous osteosarcomas and 12 nude mice transplanted with human hepatocellular carcinoma were divided randomly and were given NPS treatment, surgery or no treatment control...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28469952/long-noncoding-rna-atb-promotes-osteosarcoma-cell-proliferation-migration-and-invasion-by-suppressing-mir-200s
#9
Feng Han, Changhe Wang, Yi Wang, Liang Zhang
Long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) is a novel lncRNA, which is recently reported to have critical roles in carcinogenesis and progression of several cancers. However, the expression, clinical values, biological roles, and underlying molecular mechanisms of lncRNA-ATB in osteosarcoma are still known. In this study, we measured lncRNA-ATB expression in serum and osteosarcoma tissues of osteosarcoma patients, analyzed its diagnostic and prognostic values. Serum lncRNA-ATB is increased in osteosarcoma patients and could accurately discriminate osteosarcoma patients from healthy controls...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28459463/mycn-induces-neuroblastoma-in-primary-neural-crest-cells
#10
R R Olsen, J H Otero, J García-López, K Wallace, D Finkelstein, J E Rehg, Z Yin, Y-D Wang, K W Freeman
Neuroblastoma (NBL) is an embryonal cancer of the sympathetic nervous system (SNS), which causes 15% of pediatric cancer deaths. High-risk NBL is characterized by N-Myc amplification and segmental chromosomal gains and losses. Owing to limited disease models, the etiology of NBL is largely unknown, including both the cell of origin and the majority of oncogenic drivers. We have established a novel system for studying NBL based on the transformation of neural crest cells (NCCs), the progenitor cells of the SNS, isolated from mouse embryonic day 9...
May 1, 2017: Oncogene
https://www.readbyqxmd.com/read/28441368/skeletal-scintigraphy
#11
Jaime L Montilla-Soler, Rikesh Makanji
BACKGROUND: Skeletal scintigraphy remains a valuable tool in the initial and subsequent evaluation of the skeletal system in patients with a diagnosis of primary or metastatic neoplasms. METHODS: We discuss radiopharmaceuticals, nuclear medicine imaging techniques, and current as well as future oncological applications in the adult population. Pertinent literature was reviewed to describe the advantages and limitations of available technologies for the evaluation of skeletal metastatic disease...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28439237/biomarkers-of-osteosarcoma-chondrosarcoma-and-ewing-sarcoma
#12
REVIEW
Francesco R Evola, Luciano Costarella, Vito Pavone, Giuseppe Caff, Luca Cannavò, Andrea Sessa, Sergio Avondo, Giuseppe Sessa
Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28417853/the-role-of-18-f-fdg-pet-ct-in-pediatric-sarcoma
#13
REVIEW
Douglas J Harrison, Marguerite T Parisi, Barry L Shulkin
Considerable debate remains regarding how best to incorporate (18)F-FDG-PET/CT into clinical practice for pediatric sarcomas. Although there is a clear role for (18)F-FDG-PET/CT in staging pediatric sarcoma, the value of (18)F-FDG-PET/CT in prognostication for pediatric sarcomas remains unclear. In osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma, (18)F-FDG-PET/CT may be most useful in the identification of skeletal metastases, where the literature consistently suggests that it has improved sensitivity and specificity as compared to bone scintigraphy...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28415638/altered-long-non-coding-rnas-predict-worse-outcome-in-osteosarcoma-patients-evidence-from-a-meta-analysis
#14
Yanliang Yang, Shunli Wang, Teng Li
Long non-coding RNAs (lncRNAs) are emerging as promising prognostic biomarkers in an expanding list of malignant neoplasms. Here, we sought to investigate the strength of associations between lncRNA signatures and clinical outcomes in osteosarcoma. We conducted a systematic search of the online databases from inception to July 2016. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for the primary endpoints of overall survival (OS), progression-free survival (PFS) or event-free survival (EFS) were extracted and meta-analyzed...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415557/long-non-coding-rna-cta-sensitizes-osteosarcoma-cells-to-doxorubicin-through-inhibition-of-autophagy
#15
Zhengguang Wang, Zhendong Liu, Song Wu
Recently, several long non-coding RNAs (lncRNAs) have been implicated in osteosarcoma (OS). However, the regulatory roles of lncRNAs in chemotherapy resistance of OS still remain unclear. This study aimed to screen a novel lncRNA that contributes to chemotherapeutic resistance of OS, and to explore the underlying mechanisms. Our data showed that lncRNA CTA was markedly downregulated in OS tissues compared to their matched non-tumor tissues, and low expression of lncRNA CTA was significantly associated with the advanced clinical stage and tumor size...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409896/childhood-osteosarcoma-incidence-and-survival-in-argentina-report-from-the-national-pediatric-cancer-registry-roha-network-2000-2013
#16
F Moreno, W Cacciavillano, M Cipolla, M Coirini, P Streitenberger, J López Martí, M Palladino, M Morici, M Onoratelli, G Drago, A Schifino, M Cores, A Rose, J Jotomliansky, M Varel, M García Lombardi
BACKGROUND: Differences in incidence and survival in osteosarcoma reports are considerable worldwide. PURPOSE: This study describes the incidence and survival of patients with osteosarcoma in Argentina with data from the National Pediatric Cancer Registry (ROHA), and the impact of age, gender, stage, regional, and socioeconomic indicators on outcome. METHODS: Pediatric patients with osteosarcoma reported to ROHA from 2000 through 2013 were analyzed, the annual age-standardized incidence rate (ASR) was calculated using the National Vital Statistics, and survival was estimated...
April 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28384168/lack-of-association-between-platelet-indices-and-disease-stage-in-osteosarcoma-at-diagnosis
#17
Hongtao Li, Yonggang Wang, Zimei Liu, Yuan Yuan, Wentao Huang, Na Zhang, Aina He, Zan Shen, Yuanjue Sun, Yang Yao
PURPOSE: The purpose of this study was to investigate the relationship between platelet indices [mean platelet volume (MPV), platelet count (PLT), platelet distribution width (PDW) and plateletcrit (PCT)] at diagnosis in osteosarcoma. METHODS: The information of 233 patients with osteosarcoma at diagnosis between 2007 and 2015 was retrospectively reviewed. Clinical parameters such as gender, age, size and site of tumor, and tumor necrosis rate after neoadjuvant chemotherapy were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28381518/microrna-379-inhibits-the-proliferation-migration-and-invasion-of-human-osteosarcoma-cells-by-targetting-eif4g2
#18
Xi Xie, Yu-Sheng Li, Wen-Feng Xiao, Zhen-Han Deng, Hong-Bo He, Qing Liu, Wei Luo
Osteosarcoma (OS) is an aggressive malignant mesenchymal neoplasm amongst adolescents. The aim of the present study was to explore the various modes of action that miR-379 has on the proliferation, migration, and invasion of human OS cells. miR-379 achieves this by targetting eukaryotic initiation factor 4GII (EIF4G2). Human OS cell lines U2OS and MG-63 were selected and assigned into blank, miR-379 mimics, miR-379 mimic negative control (NC), miR-379 inhibitors, miR-379 inhibitor NC, EIF4G2 shRNA, control shRNA, and miR-379 inhibitor + EIF4G2 shRNA group...
June 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28358629/reconstruction-of-a-mandibular-segmental-defect-with-a-customized-3-dimensional-printed-titanium-prosthesis-in-a-cat-with-a-mandibular-osteosarcoma
#19
Julius M Liptak, Graham P Thatcher, Jonathan P Bray
CASE DESCRIPTION A 12-year-old neutered male domestic shorthair cat had been treated for a mass arising from the lingual aspect of the caudal right mandibular body. Cytoreductive surgery of the mass had been performed twice over a 2-year period, but the mass recurred following both surgeries. The mass was diagnosed as an osteosarcoma, and the cat was referred for further evaluation and treatment. CLINICAL FINDINGS Clinical findings were unremarkable, except for a 2-cm-diameter mass arising from the lingual aspect of the right mandible and mild anemia and lymphopenia...
April 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28356114/effectiveness-of-multi-drug-regimen-chemotherapy-treatment-in-osteosarcoma-patients-a-network-meta-analysis-of-randomized-controlled-trials
#20
Xiaojie Wang, Hong Zheng, Tao Shou, Chunming Tang, Kun Miao, Ping Wang
BACKGROUND: Osteosarcoma is the most common malignant bone tumour. Due to the high metastasis rate and drug resistance of this disease, multi-drug regimens are necessary to control tumour cells at various stages of the cell cycle, eliminate local or distant micrometastases, and reduce the emergence of drug-resistant cells. Many adjuvant chemotherapy protocols have shown different efficacies and controversial results. Therefore, we classified the types of drugs used for adjuvant chemotherapy and evaluated the differences between single- and multi-drug chemotherapy regimens using network meta-analysis...
March 29, 2017: Journal of Orthopaedic Surgery and Research
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