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https://www.readbyqxmd.com/read/28077810/increased-expression-of-long-non-coding-rna-bcar4-is-predictive-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#1
Jianhua Gong, Han Zhang, Li He, Lixin Wang, Jipeng Wang
Lung cancer is the most common human cancer, and the majority of lung cancer cases are categorized as non-small cell lung cancer (NSCLC). Long non-coding RNAs (lncRNAs) play key roles in the development and progression of human cancers. LncRNA breast cancer anti-estrogen resistance 4 (BCAR4) has been identified as an oncogenic lncRNA involved in the progression of breast cancer and osteosarcoma. However, the clinical significance of the lncRNA BCAR4 in NSCLC remains largely unclear. In the present study, real-time quantitative reverse transcriptase-polymerase chain reaction was used to examine the relative level of lncRNA BCAR4 in 68 cases of NSCLC tissues and their adjacent non-tumor tissues...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28069547/overexpression-of-mir-92a-promotes-the-tumor-growth-of-osteosarcoma-by-suppressing-f-box-and-wd-repeat-containing-protein-7
#2
Xuesheng Jiang, Xiongfeng Li, Fengfeng Wu, Hongliang Gao, Guorong Wang, Hua Zheng, Huajun Wang, Jianyou Li, Chao Chen
MicroRNAs (miRNAs) have been reported to be critical players in osteosarcoma (OS). Among numerous cancer-related miRNAs, the expression level of miR-92a and its potential role in OS has not been investigated. Here, We showed that overexpression of miR-92a was identified in OS specimens and cells compared to normal bone tissues. The high level of miR-92a was correlated with high T classification and advanced clinical stages of OS patients. Notably, miR-92a highly expressing OS patients showed a notably reduced survival rate...
January 6, 2017: Gene
https://www.readbyqxmd.com/read/28059051/microrna-133b-inhibits-cell-proliferation-and-invasion-in-osteosarcoma-by-targeting-to-sirt1
#3
Shi Ying, Huang Jianjun, Yi Xue, Yu Shuwei, Zhang Liyuan, Wang Jie, Cheng Lixian
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-133b expression level was decreased while Sirt1 mRNA expression levels were increased in osteosarcoma tissues and cell lines. Low expression of miR-133b was significantly associated with the tumor size, distant metastasis and advanced clinical stage; and the osteosarcoma patients with low miR-133b expression showed a worse prognosis when compared with those with high level of miR-133b...
January 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28031047/pathological-fractures-in-predicting-clinical-outcomes-for-patients-with-osteosarcoma
#4
Lien-Hsiang Chung, Po-Kuei Wu, Cheng-Fong Chen, Hung-Kai Weng, Tain-Hsiung Chen, Wei-Ming Chen
BACKGROUND: Studies reported contradictory results for the prognostic significance of a pathological fracture in osteosarcoma patients. The aim of this study is to report the outcomes for a cohort of patients with osteosarcoma who presented with and without pathological fractures and to identify the prognostic importance of pathological fracture in predicting outcomes and influences on survival. METHODS: Data of patients with osteosarcoma were retrospectively reviewed...
December 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28009431/up-regulation-of-long-noncoding-rna-ccal-predicts-poor-patient-prognosis-and-promotes-tumor-metastasis-in-osteosarcoma
#5
Da-Kai Zhou, Xi-Wang Yang, Huining Li, Yongbo Yang, Zhen-Jun Zhu, Na Wu
BACKGROUND: Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. Aberrant colorectal cancer-associated lncRNA (CCAL) has been found in colorectal cancer. However, the function of lncRNA CCAL in osteosarcoma (OS) remains unclear. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure CCAL expression in OS tissues and adjacent nontumor tissues. The correlation betweent CCAL expression and clinicopathological features and prognosis was also analyzed...
December 22, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28008378/association-of-circulating-mir-125b-and-survival-in-patients-with-osteosarcoma-a-single-center-experience
#6
Zhiqiang Luo, Minglu Liu, Haihong Zhang, Yayi Xia
BACKGROUND: It is known that miRNAs play various roles in malignant tumors. This study is designed to investigate whether miR-125b levels can be used to predict the clinical response of patients with osteosarcoma (OS) to cisplatin-based chemotherapy. METHODS: From January 2010 to July 2015, 82 patients with resectable OS and 56 patients with unresectable OS were enrolled. Blood samples were collected and quantitative real-time PCR was applied to determine miR-125b expression...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28002586/correlation-between-trail-and-caspase-8-expression-and-their-relationship-with-cell-proliferation-and-apoptosis-in-human-osteosarcoma
#7
X Ning, X W Shang, Y Zhuang, M Liu, H Yang, H Zhang, M Z Huang
Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with cell proliferation and apoptosis. Osteosarcoma and osteochondroma patients receiving surgery in our hospital were selected...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27994653/association-of-common-variants-in-mtap-with-susceptibility-and-overall-survival-of-osteosarcoma-a-two-stage-population-based-study-in-han-chinese
#8
Liqiang Zhi, Dan Liu, Stephen G Wu, Tianqing Li, Guanghui Zhao, Bo Zhao, Meng Li
Osteosarcoma (OS) is a common malignant tumor, which exists widely in the bone of children and adolescents, and genetic factors may influence its susceptibility. Recently, the gene MTAP has been reported to be associated with OS in a Caucasian population. To investigate the association of common variants in MTAP with OS risk in Han Chinese individuals, we designed a two-stage case-control study with 392 OS patients and 1,578 unrelated healthy controls of Han Chinese individuals. A total of 17 tagging single nucleotide polymorphisms (SNPs) were firstly genotyped in the discovery stage, and single-SNP association and haplotypic association analyses have been performed...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27922432/mir-21-predicts-poor-prognosis-in-patients-with-osteosarcoma
#9
Xianfeng Ren, Yuqin Shen, Shuyun Zheng, JianYong Liu, Xin Jiang
BACKGROUND AND AIMS: miR-21 has been demonstrated to play an important role in tumour progression. The aim of the present study was to analyse the correlation between miR-21 expression level and clinicopathologic features, as well as to assess the prognostic significance of miR-21 in osteosarcoma. METHODS: Eighty-four pairs of osteosarcoma and corresponding non-cancerous bone tissues were obtained, and miR-21 expression levels were detected using quantitative real-time PCR (qRT-PCR)...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27917340/serum-mir-95-3p-is-a-diagnostic-and-prognostic-marker-for-osteosarcoma
#10
Junjie Niu, Yibao Sun, Qiaoge Guo, Dongju Niu, Bo Liu
It has been demonstrated that microRNAs (miRNAs or miRs) can act as prognostic and diagnostic markers, and potential therapeutic targets. miR-95-3p has been reported to be downregulated in osteosarcoma tissues, but its potential as a serum biomarker has not been assessed in human osteosarcoma. The purpose of the present study was to examine the expression levels of miR-95-3p in serum of patients with osteosarcoma and to investigate the diagnostic and prognostic value of miR-95-3p. The serum levels of miR-95-3p in osteosarcoma patients were detected by a real-time quantitative reverse transcription-polymerase chain reaction assay...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27914228/osteoblastic-extraosseous-osteosarcoma-of-the-neck
#11
Andro Košec, Majda Vučić, Vladimir Bedeković, Mirko Ivkić
Extraosseous osteosarcoma as a primary tumor of the neck is exceedingly rare, with only a few cases reported to date. The most appropriate therapy is still under investigation. We report a case of an aggressive, right-sided, advanced-stage extraosseous osteosarcoma in a female patient. A 48-year-old woman presented with a right-sided infra-parotid mass encompassing neck regions II and III, measuring over 6 cm in craniocaudal diameter. She was initially treated by wide surgical resection. The definitive histopathologic diagnosis was osteoblastic extraosseous osteosarcoma...
November 16, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27906470/retrospective-evaluation-of-whole-body-computed-tomography-for-tumor-staging-in-dogs-with-primary-appendicular-osteosarcoma
#12
Jessica L Talbott, Sarah E Boston, Rowan J Milner, Amandine Lejeune, Carlos H de M Souza, Kelvin Kow, Nicholas J Bacon, Jorge A Hernandez
OBJECTIVE: To evaluate whole body computed tomography (CT) for staging canine appendicular osteosarcoma. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs diagnosed with appendicular osteosarcoma (n=39). METHODS: Medical records for client-owned dogs diagnosed with appendicular osteosarcoma from August 2008 to July 2014 were reviewed. Dogs were included if they had a confirmed diagnosis of appendicular osteosarcoma and were staged using whole body CT...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27904684/ldhb-may-be-a-significant-predictor-of-poor-prognosis-in-osteosarcoma
#13
Chao Li, Yu Chen, Pingping Bai, Jiaqiang Wang, Zhenhui Liu, Tao Wang, Qiqing Cai
Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Lactate dehydrogenase (LDH) is considered as the key glycolytic enzyme and involved in tumor initiation and metabolism. Here, we firstly found that LDHB was highly expressed in osteosarcoma cell lines. Expression profiling indicated that LDHB mRNA was elevated in osteosarcoma tissues with metastasis versus without metastasis, and LDHB high expression predicted a poor prognosis in patients. After LDHB knockdown by siRNA transfection, cell growth and proliferation were inhibited and presented a dose-dependent cell death via MTT assay...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27895748/serum-mir-300-as-a-diagnostic-and-prognostic-biomarker-in-osteosarcoma
#14
Jian-Dong Liu, Qun Xin, Chun-Sheng Tao, Pei-Feng Sun, Peng Xu, Bing Wu, Liang Qu, Shu-Zhong Li
In order to determine whether microRNA (miR)-300 is a diagnostic and prognostic biomarker in osteosarcoma, the miR-300 levels in serum of 114 osteosarcoma patients and 114 healthy controls were compared, followed by serum analysis of the differences between the pre-operative and post-operative sera of these osteosarcoma patients. It was observed that the concentration levels of miR-300 in the serum of osteosarcoma patients was significantly higher than those in the serum of healthy controls (P<0.01). Furthermore, the concentration levels of miR-300 in the post-operative serum were significantly reduced when compared with the pre-operative serum levels (P<0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27880743/ras-association-domain-family-1-isoform-a-rassf1a-gene-polymorphism-rs1989839-is-associated-with-risk-and-metastatic-potential-of-osteosarcoma-in-young-chinese-individuals-a-multi-center-case-control-study
#15
Hongwei Xu, Wang Zhan, Zhiyuan Chen
BACKGROUND The ras-association domain family 1 isoform A (RASSF1A) gene serves as a bona fide tumor suppressor gene. The polymorphisms in RASSF1A were previously reported to be associated with the risk of solid malignant tumors. We hypothesized herein that RASSF1A gene polymorphisms are involved in the risk and prognosis of osteosarcoma (OS). MATERIAL AND METHODS We recruited 279 young OS cases and 286 tumor-free controls from the east Chinese population. Five tagSNPs of RASSF1A gene (rs2236947A/C, rs2073497A/C, rs1989839C/T, rs72932987C/T, and rs4688728G/T) were genotyped...
November 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27874956/up-regulation-of-long-non-coding-rna-bcar4-predicts-a-poor-prognosis-in-patients-with-osteosarcoma-and-promotes-cell-invasion-and-metastasis
#16
L Ju, Y-M Zhou, G-S Yang
OBJECTIVE: The long non-coding RNA BCAR4 (BCAR4) has been reported to be associated with cancer development. The aim of our study was to investigate the expression of BCAR4 in osteosarcoma patients and its association with clinicopathologic parameters and the prognosis. PATIENTS AND METHODS: Quantitative RT-PCR (qRT-PCR) assay was used to detect the expression of BCAR4 and its correlations with clinicopathological factors were statistically analyzed. The clinical and prognostic significance of BCAR4 expression was analyzed statistically by Kaplan-Meier estimate and Cox regression model...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27860191/perinatal-factors-associated-with-clinical-presentation-of-osteosarcoma-in-children-and-adolescents
#17
Alyson A Endicott, Libby M Morimoto, Cassie N Kline, Joseph L Wiemels, Catherine Metayer, Kyle M Walsh
BACKGROUND: Osteosarcoma typically develops during puberty with tumors arising at sites of rapid bone growth, suggesting a role for growth-regulating pathways in tumor etiology. Birthweight is one measure of perinatal growth that has been investigated as an osteosarcoma risk factor. Whether birthweight affects clinical features of osteosarcoma remains unexplored. METHOD: Six hundred seventy patients with osteosarcoma, aged 0-19 years, were identified through the California Cancer Registry...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27853827/increased-pd-l1-and-t-cell-infiltration-in-the-presence-of-hla-class-i-expression-in-metastatic-high-grade-osteosarcoma-a-rationale-for-t-cell-based-immunotherapy
#18
Yayan T Sundara, Marie Kostine, Arjen H G Cleven, Judith V M G Bovée, Marco W Schilham, Anne-Marie Cleton-Jansen
INTRODUCTION: Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating neoantigens. In this study, we aim to investigate the HLA class I expression, PD-L1 and tumour-infiltrating lymphocytes in primary osteosarcomas and relapses/metastases, as well as their changes during disease progression. MATERIALS AND METHODS: Tumour samples from multiple stages of the disease (pretreatment biopsies, surgical resections of primary osteosarcomas, relapses and metastases) were collected and stained for HLA-A (HCA2), HLA-B/C (HC10), β2-microglobulin and PD-L1 using immunohistochemistry on whole sections...
November 16, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27829995/long-noncoding-rna-zeb1-as1-acts-as-an-oncogene-in-osteosarcoma-by-epigenetically-activating-zeb1
#19
Chibo Liu, Jianjun Lin
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles and potential mechanism of lncRNA ZEB1-AS1 in osteosarcoma are still unknown. In this study, we measured ZEB1-AS1 expression and the results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27826039/amphiregulin-enhances-vegf-a-production-in-human-chondrosarcoma-cells-and-promotes-angiogenesis-by-inhibiting-mir-206-via-fak-c-src-pkc%C3%AE-pathway
#20
Chao-Qun Wang, Yu-Wen Huang, Shih-Wei Wang, Yuan-Li Huang, Chun-Hao Tsai, Yong-Ming Zhao, Bi-Fei Huang, Guo-Hong Xu, Yi-Chin Fong, Chih-Hsin Tang
Chondrosarcoma is the second most common primary malignancy of bone after myeloma and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). The expression of VEGF-A has been recognized as a prognostic marker in angiogenesis. Amphiregulin (AR), an epidermal growth factor receptor ligand, promotes tumor proliferation, metastasis and angiogenesis. However, the role of AR in VEGF-A expression and angiogenesis in human chondrosarcoma remains largely unknown...
January 28, 2017: Cancer Letters
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