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https://www.readbyqxmd.com/read/27922432/mir-21-predicts-poor-prognosis-in-patients-with-osteosarcoma
#1
Xianfeng Ren, Yuqin Shen, Shuyun Zheng, JianYong Liu, Xin Jiang
BACKGROUND AND AIMS: miR-21 has been demonstrated to play an important role in tumour progression. The aim of the present study was to analyse the correlation between miR-21 expression level and clinicopathologic features, as well as to assess the prognostic significance of miR-21 in osteosarcoma. METHODS: Eighty-four pairs of osteosarcoma and corresponding non-cancerous bone tissues were obtained, and miR-21 expression levels were detected using quantitative real-time PCR (qRT-PCR)...
October 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27917340/serum-mir-95-3p-is-a-diagnostic-and-prognostic-marker-for-osteosarcoma
#2
Junjie Niu, Yibao Sun, Qiaoge Guo, Dongju Niu, Bo Liu
It has been demonstrated that microRNAs (miRNAs or miRs) can act as prognostic and diagnostic markers, and potential therapeutic targets. miR-95-3p has been reported to be downregulated in osteosarcoma tissues, but its potential as a serum biomarker has not been assessed in human osteosarcoma. The purpose of the present study was to examine the expression levels of miR-95-3p in serum of patients with osteosarcoma and to investigate the diagnostic and prognostic value of miR-95-3p. The serum levels of miR-95-3p in osteosarcoma patients were detected by a real-time quantitative reverse transcription-polymerase chain reaction assay...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27914228/osteoblastic-extraosseous-osteosarcoma-of-the-neck
#3
Andro Košec, Majda Vučić, Vladimir Bedeković, Mirko Ivkić
Extraosseous osteosarcoma as a primary tumor of the neck is exceedingly rare, with only a few cases reported to date. The most appropriate therapy is still under investigation. We report a case of an aggressive, right-sided, advanced-stage extraosseous osteosarcoma in a female patient. A 48-year-old woman presented with a right-sided infra-parotid mass encompassing neck regions II and III, measuring over 6 cm in craniocaudal diameter. She was initially treated by wide surgical resection. The definitive histopathologic diagnosis was osteoblastic extraosseous osteosarcoma...
November 16, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27906470/retrospective-evaluation-of-whole-body-computed-tomography-for-tumor-staging-in-dogs-with-primary-appendicular-osteosarcoma
#4
Jessica L Talbott, Sarah E Boston, Rowan J Milner, Amandine Lejeune, Carlos H de M Souza, Kelvin Kow, Nicholas J Bacon, Jorge A Hernandez
OBJECTIVE: To evaluate whole body computed tomography (CT) for staging canine appendicular osteosarcoma. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs diagnosed with appendicular osteosarcoma (n=39). METHODS: Medical records for client-owned dogs diagnosed with appendicular osteosarcoma from August 2008 to July 2014 were reviewed. Dogs were included if they had a confirmed diagnosis of appendicular osteosarcoma and were staged using whole body CT...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27904684/ldhb-may-be-a-significant-predictor-of-poor-prognosis-in-osteosarcoma
#5
Chao Li, Yu Chen, Pingping Bai, Jiaqiang Wang, Zhenhui Liu, Tao Wang, Qiqing Cai
Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Lactate dehydrogenase (LDH) is considered as the key glycolytic enzyme and involved in tumor initiation and metabolism. Here, we firstly found that LDHB was highly expressed in osteosarcoma cell lines. Expression profiling indicated that LDHB mRNA was elevated in osteosarcoma tissues with metastasis versus without metastasis, and LDHB high expression predicted a poor prognosis in patients. After LDHB knockdown by siRNA transfection, cell growth and proliferation were inhibited and presented a dose-dependent cell death via MTT assay...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27895748/serum-mir-300-as-a-diagnostic-and-prognostic-biomarker-in-osteosarcoma
#6
Jian-Dong Liu, Qun Xin, Chun-Sheng Tao, Pei-Feng Sun, Peng Xu, Bing Wu, Liang Qu, Shu-Zhong Li
In order to determine whether microRNA (miR)-300 is a diagnostic and prognostic biomarker in osteosarcoma, the miR-300 levels in serum of 114 osteosarcoma patients and 114 healthy controls were compared, followed by serum analysis of the differences between the pre-operative and post-operative sera of these osteosarcoma patients. It was observed that the concentration levels of miR-300 in the serum of osteosarcoma patients was significantly higher than those in the serum of healthy controls (P<0.01). Furthermore, the concentration levels of miR-300 in the post-operative serum were significantly reduced when compared with the pre-operative serum levels (P<0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27880743/ras-association-domain-family-1-isoform-a-rassf1a-gene-polymorphism-rs1989839-is-associated-with-risk-and-metastatic-potential-of-osteosarcoma-in-young-chinese-individuals-a-multi-center-case-control-study
#7
Hongwei Xu, Wang Zhan, Zhiyuan Chen
BACKGROUND The ras-association domain family 1 isoform A (RASSF1A) gene serves as a bona fide tumor suppressor gene. The polymorphisms in RASSF1A were previously reported to be associated with the risk of solid malignant tumors. We hypothesized herein that RASSF1A gene polymorphisms are involved in the risk and prognosis of osteosarcoma (OS). MATERIAL AND METHODS We recruited 279 young OS cases and 286 tumor-free controls from the east Chinese population. Five tagSNPs of RASSF1A gene (rs2236947A/C, rs2073497A/C, rs1989839C/T, rs72932987C/T, and rs4688728G/T) were genotyped...
November 23, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27874956/up-regulation-of-long-non-coding-rna-bcar4-predicts-a-poor-prognosis-in-patients-with-osteosarcoma-and-promotes-cell-invasion-and-metastasis
#8
L Ju, Y-M Zhou, G-S Yang
OBJECTIVE: The long non-coding RNA BCAR4 (BCAR4) has been reported to be associated with cancer development. The aim of our study was to investigate the expression of BCAR4 in osteosarcoma patients and its association with clinicopathologic parameters and the prognosis. PATIENTS AND METHODS: Quantitative RT-PCR (qRT-PCR) assay was used to detect the expression of BCAR4 and its correlations with clinicopathological factors were statistically analyzed. The clinical and prognostic significance of BCAR4 expression was analyzed statistically by Kaplan-Meier estimate and Cox regression model...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27860191/perinatal-factors-associated-with-clinical-presentation-of-osteosarcoma-in-children-and-adolescents
#9
Alyson A Endicott, Libby M Morimoto, Cassie N Kline, Joseph L Wiemels, Catherine Metayer, Kyle M Walsh
BACKGROUND: Osteosarcoma typically develops during puberty with tumors arising at sites of rapid bone growth, suggesting a role for growth-regulating pathways in tumor etiology. Birthweight is one measure of perinatal growth that has been investigated as an osteosarcoma risk factor. Whether birthweight affects clinical features of osteosarcoma remains unexplored. METHOD: Six hundred seventy patients with osteosarcoma, aged 0-19 years, were identified through the California Cancer Registry...
November 10, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27853827/increased-pd-l1-and-t-cell-infiltration-in-the-presence-of-hla-class-i-expression-in-metastatic-high-grade-osteosarcoma-a-rationale-for-t-cell-based-immunotherapy
#10
Yayan T Sundara, Marie Kostine, Arjen H G Cleven, Judith V M G Bovée, Marco W Schilham, Anne-Marie Cleton-Jansen
INTRODUCTION: Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating neoantigens. In this study, we aim to investigate the HLA class I expression, PD-L1 and tumour-infiltrating lymphocytes in primary osteosarcomas and relapses/metastases, as well as their changes during disease progression. MATERIALS AND METHODS: Tumour samples from multiple stages of the disease (pretreatment biopsies, surgical resections of primary osteosarcomas, relapses and metastases) were collected and stained for HLA-A (HCA2), HLA-B/C (HC10), β2-microglobulin and PD-L1 using immunohistochemistry on whole sections...
November 16, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27829995/long-noncoding-rna-zeb1-as1-acts-as-an-oncogene-in-osteosarcoma-by-epigenetically-activating-zeb1
#11
Chibo Liu, Jianjun Lin
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles and potential mechanism of lncRNA ZEB1-AS1 in osteosarcoma are still unknown. In this study, we measured ZEB1-AS1 expression and the results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27826039/amphiregulin-enhances-vegf-a-production-in-human-chondrosarcoma-cells-and-promotes-angiogenesis-by-inhibiting-mir-206-via-fak-c-src-pkc%C3%AE-pathway
#12
Chao-Qun Wang, Yu-Wen Huang, Shih-Wei Wang, Yuan-Li Huang, Chun-Hao Tsai, Yong-Ming Zhao, Bi-Fei Huang, Guo-Hong Xu, Yi-Chin Fong, Chih-Hsin Tang
Chondrosarcoma is the second most common primary malignancy of bone after myeloma and osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). The expression of VEGF-A has been recognized as a prognostic marker in angiogenesis. Amphiregulin (AR), an epidermal growth factor receptor ligand, promotes tumor proliferation, metastasis and angiogenesis. However, the role of AR in VEGF-A expression and angiogenesis in human chondrosarcoma remains largely unknown...
November 5, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27821833/-pulmonary-carcinosarcoma-presenting-hemothorax-caused-by-pleural-invasion-report-of-a-case
#13
Nobukata Kazawa, Yuta Shibamoto, Yukiya Kitabayashi, Yumi Ishihara, Taeko Gotoh, Yuusuke Sawada, Ryo Inukai, Takashi Tsujimura, Hideo Hattori, Akio Niimi, Ryoichi Nakanishi, Masanori Kitaichi
A 71-year-old man presented with hemothorax with cough, sputa and worsening dyspnea. On chest X-ray and computed tomography(CT), a huge tumor in the right upper lobe with hematoma and small amount of gas suggesting hemopneumothorax was revealed. No apparent lymphadenopathy nor intrapulmonary metastases were observed. The tumor showed a little enhancement on the contrastenhanced CT. Then the resction of the tumor was performed, and the pathological evaluation revealed a carcionosarcoma (adenocarcinoma+osteosarcoma) pT3N0 (stage II B) G4 pl2...
November 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27735043/mir-497-as-a-potential-serum-biomarker-for-the-diagnosis-and-prognosis-of-osteosarcoma
#14
P-C Pang, X-Y Shi, W-L Huang, K Sun
OBJECTIVE: The aim of this manuscript is to analyze the diagnostic and prognostic value of circulating miR-497 in the plasma of patients with osteosarcoma. PATIENTS AND METHODS: Serum miR-497 expression levels were measured by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). Correlations between miR-497 expression and the clinicopathological features and prognosis of osteosarcoma patients were then evaluated. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were used to evaluate diagnostic accuracy...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27723574/mir-326-is-a-diagnostic-biomarker-and-regulates-cell-survival-and-apoptosis-by-targeting-bcl-2-in-osteosarcoma
#15
Lei Cao, Jiandong Wang, Prof Qiugen Wang
Osteosarcoma is a malignant bone tumor in which the survival rate is still low. MicroRNA-326 (miR-326) has been proved a potential diagnostic and prognostic marker for several tumors. However, the clinical value of miR-326 is still unknown. In the present study, we detected the expression of miR-326 in the serum of osteosarcoma patients and in osteosarcoma tissues using qRT-PCR. We compared the serum expression of miR-326 with the clinicopathological characteristics and survival of osteosarcoma patients. Finally, we explored the role of miR-326 of the invasion of osteosarcoma tumor cells using cell migration and invasion assays...
October 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27701417/pyrophosphate-stimulates-differentiation-matrix-gene-expression-and-alkaline-phosphatase-activity-in-osteoblasts
#16
Michael Pujari-Palmer, Shiuli Pujari-Palmer, Xi Lu, Thomas Lind, Håkan Melhus, Thomas Engstrand, Marjam Karlsson-Ott, Hakan Engqvist
Pyrophosphate is a potent mitogen, capable of stimulating proliferation in multiple cell types, and a critical participant in bone mineralization. Pyrophosphate can also affect the resorption rate and bioactivity of orthopedic ceramics. The present study investigated whether calcium pyrophosphate affected proliferation, differentiation and gene expression in early (MC3T3 pre-osteoblast) and late stage (SAOS-2 osteosarcoma) osteoblasts. Pyrophosphate stimulated peak alkaline phosphatase activity by 50% and 150% at 100μM and 0...
2016: PloS One
https://www.readbyqxmd.com/read/27650817/initial-testing-stage-1-of-the-curaxin-cbl0137-by-the-pediatric-preclinical-testing-program
#17
Richard Lock, Hernan Carol, John M Maris, E Anders Kolb, Richard Gorlick, C Patrick Reynolds, Min H Kang, Stephen T Keir, Jianrong Wu, Andrei Purmal, Andrei Gudkov, Dias Kurmashev, Raushan T Kurmasheva, Peter J Houghton, Malcolm A Smith
BACKGROUND: CBL0137 is a novel drug that modulates FAcilitates Chromatin Transcription (FACT), resulting in simultaneous nuclear factor-κB suppression, heat shock factor 1 suppression and p53 activation. CBL0137 has demonstrated antitumor effects in animal models of several adult cancers and neuroblastoma. PROCEDURES: CBL0137 was tested against the Pediatric Preclinical Testing Program (PPTP) in vitro cell line panel at concentrations ranging from 1.0 nM to 10...
September 21, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27650618/sdf-1-expression-is-associated-with-poor-prognosis-in-osteosarcoma
#18
Dangen Yu, Fei Lv, Jianhe Zhang, Hongjie Li
BACKGROUND: Stromal cell-derived factor-1 (SDF-1) expression has been reported to be a predictor of poor clinical symptoms in certain types of cancer. Vascular endothelial growth factor (VEGF) is a well-known factor that mediates the micro-angiogenesis of solid tumors, and SDF-1 mediated expression of VEGF may promote tumor growth and metastasis, resulting in poor clinical outcome. Therefore, we explored the expression levels of SDF-1 and VEGF in patients with osteosarcoma in order to determine the association between their expression levels and unfavorable outcomes...
September 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27649655/long-non-coding-rna-malat1-is-an-independent-prognostic-factor-of-osteosarcoma
#19
K-T Gao, D Lian
OBJECTIVE: Accumulating evidence revealed that long non-coding RNAs (lncRNAs) were emerging regulators in cancer biology, and could be used as potential biomarkers for cancer prognosis. In this study, we focused on MALAT1 and investigated its expression pattern, clinical significance in osteosarcoma. PATIENTS AND METHODS: The expression of lncRNA MALAT1 was analyzed in 162 osteosarcoma tissues by quantitative real-time PCR (qRT-PCR). Then, we explored the potential relationship between MALAT1 expression levels in tumor tissues and clinicopathological features of osteosarcoma, and clinical outcome...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27648140/upregulation-of-lncrna-hnf1a-as1-promotes-cell-proliferation-and-metastasis-in-osteosarcoma-through-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#20
Hongxing Zhao, Wengen Hou, Jingang Tao, Yilei Zhao, Guang Wan, Chao Ma, Haibin Xu
HNF1A-antisense 1 (HNF1A-AS1), a long non-coding RNA (lncRNA), is associated with metastasis and is an independent prognostic factor for lung cancer. Recent studies demonstrated that HNF1A-AS1 play important roles in cacinogenesis. However, the exact effects and molecular mechanisms of HNF1A-AS1 in osteosarcoma (OS) progression is still unclear. In the present study, we found that HNF1A-AS1 was markedly up-regulated in OS tissues compared to their adjacent non-tumor tissues. HNF1A-AS1 expression levels were positively associated with the clinical stage, distant metastasis, and reduced overall survival of OS patients...
2016: American Journal of Translational Research
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