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https://www.readbyqxmd.com/read/28224623/outcome-and-prognostic-factors-following-curative-intent-surgery-for-oral-tumours-in-dogs-234-cases-2004-to-2014
#1
B N Sarowitz, G J Davis, S Kim
OBJECTIVES: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs. METHODS: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction...
February 22, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28223819/the-clinical-significance-of-the-ezrin-gene-and-circulating-tumor-cells-in-osteosarcoma
#2
Guang-Xian Zhong, Shao-Dan Feng, Rongkai Shen, Zhao-Yang Wu, Fei Chen, Xia Zhu
PURPOSE: The aim of this study was to investigate the clinical significance of circulating tumor cells (CTCs) in the peripheral blood of an osteosarcoma and the Ezrin gene expressed in CTCs. PATIENTS AND METHODS: CTC enrichment was done with CanPatrol™ CTC enrichment technique in 41 patients with osteosarcoma. The characterization of CTCs was performed using a multiple messenger RNA in situ analysis (MRIA). The expression of the Ezrin gene in CTCs was detected by RNA probe technology...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28214202/elevated-expression-of-microrna-19a-predicts-a-poor-prognosis-in-patients-with-osteosarcoma
#3
Pingzhou Zou, Jian Ding, Shiping Fu
MicroRNA (miR)-19a, a member of the miR-17-92 cluster, functions as an oncomiRNA in multiple kinds of cancers. However, its involvement in human osteosarcomas remains unclear. In this study, to analyze the expression pattern of miR-19a and to investigate its clinical implication in human osteosarcomas, quantitative reverse-transcription polymerase chain reaction was performed to detect expression levels of miR-19a in 166 self-pairs of osteosarcoma and noncancerous bone tissues. Associations between miR-19a expression and various clinicopathological parameters and patients' prognosis of osteosarcomas were further evaluated...
December 29, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28196121/prognostic-significance-of-chemotherapy-induced-necrosis-in-osteosarcoma-patients-receiving-pasteurized-autografts
#4
Min Wook Joo, Yong Koo Kang, Chang-Young Yoo, Sung Ho Cha, Yang-Guk Chung
BACKGROUND: Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion removed from a wide-resection specimen is available when using pasteurized autograft method. The assessment, therefore, may be unreliable. We analyzed the prognostic significance of the chemotherapy-induced necrosis in osteosarcoma patients who underwent reconstruction with pasteurized autografts...
2017: PloS One
https://www.readbyqxmd.com/read/28195881/comparison-of-the-ajcc-msts-and-modified-spanier-systems-for-clinical-and-pathologic-staging-of-osteosarcoma
#5
Justin M M Cates
The prognostic performance of the 2 most commonly used staging systems for skeletal sarcoma (the American Joint Committee on Cancer [AJCC] and Musculoskeletal Tumor Society [MSTS] systems) have never been compared analytically. Another staging system originally proposed by Spanier has not yet been validated. Given the recent release of the 8th edition of the AJCC Cancer Staging Manual, this study was designed to directly compare these anatomic staging systems in a series of 153 high-grade, intramedullary osteosarcomas...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28194714/is-limb-salvage-with-microwave-induced-hyperthermia-better-than-amputation-for-osteosarcoma-of-the-distal-tibia
#6
Kang Han, Peiye Dang, Na Bian, Xiang Chen, Tongtao Yang, QingYu Fan, Yong Zhou, Tingbao Zhao, Pingshan Wang
BACKGROUND: Amputation has been the standard surgical treatment for distal tibia osteosarcoma owing to its unique anatomic features. Preliminary research suggested that microwave-induced hyperthermia may have a role in treating osteosarcoma in some locations of the body (such as the pelvis), but to our knowledge, no comparative study has evaluated its efficacy in a difficult-to-treat location like the distal tibia. QUESTIONS: Does microwave-induced hyperthermia result in (1) improved survival, (2) decreased local recurrence, (3) improved Musculoskeletal Tumor Society (MSTS) scores, or (4) fewer complications than amputation in patients with a distal tibial osteosarcoma? METHODS: Between 2000 and 2015, we treated 79 patients for a distal tibia osteosarcoma without metastases...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28188704/cnot1-cooperates-with-lmna-to-aggravate-osteosarcoma-tumorigenesis-through-the-hedgehog-signaling-pathway
#7
Dong-Dong Cheng, Jing Li, Shi-Jie Li, Qing-Cheng Yang, Cun-Yi Fan
While treatments for childhood osteosarcoma have improved, the overall survival for this common type of bone cancer have not changed for three decades and thus new targets for therapeutic development are needed. To identify tumor-related proteins in osteosarcoma, we used isobaric tags in a relative and absolute quantitation (iTRAQ) proteomic approach to analyze the differentially expressed proteins between osteosarcoma cells and human osteoblastic cells. Through clinical screening and functional evaluation, CCR4-NOT transcription complex subunit 1 (CNOT1) correlated to the growth of osteosarcoma cells...
February 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28165565/decreased-expression-of-mir-490-3p-in-osteosarcoma-and-its-clinical-significance
#8
B Tang, C Liu, Q-M Zhang, M Ni
OBJECTIVE: Increasing evidence has revealed that miRNAs play a key role in the development and progression of tumor and are being explored as a prognostic biomarker. The aim of this study was to investigate the clinical significance of miR-490-3p expression in osteosarcoma. PATIENTS AND METHODS: Quantitative real-time PCR (qRT-PCR) was used to evaluate miR-490-3p level in osteosarcoma tissues. We also analyzed the correlations between the expression level of miR-490-3p and the clinical characteristics in cases of osteosarcoma...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28163298/correlations-between-hector-battifora-mesothelial-1-hbme-1-expression-and-clinical-pathological-characteristics-and-prognosis-of-osteosarcoma-patients
#9
Yu-Xin Zhao, Song-Tao Gao, Jia-Qiang Wang, Wei-Tao Yao, Yi-Sheng Wang, Cai-Li Guo
BACKGROUND The aim of this study was to investigate the correlation between Hector Battifora mesothelial-1 (HBME-1) expression and the clinical pathological characteristics and prognosis of osteosarcoma (OS). MATERIAL AND METHODS HBME-1 expression was assessed using immunohistochemistry in OS tissues (n=152), osteochondroma tissues (n=91), and normal bone tissues (n=74). We carried out a follow-up lasting 8-60 months to investigate HBME-1 expression and its correlations with the clinical pathological characteristics and prognosis of OS...
February 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28108312/ctgf-promotes-osteosarcoma-angiogenesis-by-regulating-mir-543-angiopoietin-2-signaling
#10
Li-Hong Wang, Hsiao-Chi Tsai, Yu-Che Cheng, Chih-Yang Lin, Yuan-Li Huang, Chun-Hao Tsai, Guo-Hong Xu, Shih-Wei Wang, Yi-Chin Fong, Chih-Hsin Tang
Osteosarcoma is the most common primary solid tumor of bone. It has a high metastatic potential and occurs predominantly in adolescents and young adults. Angiopoietin 2 (Angpt2) is a key regulator in tumor angiogenesis, facilitating tumor growth and metastasis. Connective tissue growth factor (CTGF, also known as CCN2), is a cysteine-rich protein that has been reported to promote metastasis of osteosarcoma. However, the effect of CTGF on Angpt2 regulation and angiogenesis in human osteosarcoma remains largely unknown...
January 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28103887/microrna-expression-patterns-and-signalling-pathways-in-the-development-and-progression-of-childhood-solid-tumours
#11
REVIEW
Anna L Leichter, Michael J Sullivan, Michael R Eccles, Aniruddha Chatterjee
The development of childhood solid tumours is tied to early developmental processes. These tumours may be complex and heterogeneous, and elucidating the aberrant mechanisms that alter the early embryonic environment and lead to disease is essential to our understanding of how these tumours function. MicroRNAs (miRNAs) are vital regulators of gene expression at all stages of development, and their crosstalk via developmental signalling pathways is essential for orchestrating regulatory control in processes such as proliferation, differentiation and apoptosis of cells...
January 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28077810/increased-expression-of-long-non-coding-rna-bcar4-is-predictive-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#12
Jianhua Gong, Han Zhang, Li He, Lixin Wang, Jipeng Wang
Lung cancer is the most common human cancer, and the majority of lung cancer cases are categorized as non-small cell lung cancer (NSCLC). Long non-coding RNAs (lncRNAs) play key roles in the development and progression of human cancers. LncRNA breast cancer anti-estrogen resistance 4 (BCAR4) has been identified as an oncogenic lncRNA involved in the progression of breast cancer and osteosarcoma. However, the clinical significance of the lncRNA BCAR4 in NSCLC remains largely unclear. In the present study, real-time quantitative reverse transcriptase-polymerase chain reaction was used to examine the relative level of lncRNA BCAR4 in 68 cases of NSCLC tissues and their adjacent non-tumor tissues...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28069547/overexpression-of-mir-92a-promotes-the-tumor-growth-of-osteosarcoma-by-suppressing-f-box-and-wd-repeat-containing-protein-7
#13
Xuesheng Jiang, Xiongfeng Li, Fengfeng Wu, Hongliang Gao, Guorong Wang, Hua Zheng, Huajun Wang, Jianyou Li, Chao Chen
MicroRNAs (miRNAs) have been reported to be critical players in osteosarcoma (OS). Among numerous cancer-related miRNAs, the expression level of miR-92a and its potential role in OS has not been investigated. Here, We showed that overexpression of miR-92a was identified in OS specimens and cells compared to normal bone tissues. The high level of miR-92a was correlated with high T classification and advanced clinical stages of OS patients. Notably, miR-92a highly expressing OS patients showed a notably reduced survival rate...
March 30, 2017: Gene
https://www.readbyqxmd.com/read/28059051/microrna-133b-inhibits-cell-proliferation-and-invasion-in-osteosarcoma-by-targeting-to-sirt1
#14
Shi Ying, Huang Jianjun, Yi Xue, Yu Shuwei, Zhang Liyuan, Wang Jie, Cheng Lixian
MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. In this study, we showed that miR-133b expression level was decreased while Sirt1 mRNA expression levels were increased in osteosarcoma tissues and cell lines. Low expression of miR-133b was significantly associated with the tumor size, distant metastasis and advanced clinical stage; and the osteosarcoma patients with low miR-133b expression showed a worse prognosis when compared with those with high level of miR-133b...
January 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28031047/pathological-fractures-in-predicting-clinical-outcomes-for-patients-with-osteosarcoma
#15
Lien-Hsiang Chung, Po-Kuei Wu, Cheng-Fong Chen, Hung-Kai Weng, Tain-Hsiung Chen, Wei-Ming Chen
BACKGROUND: Studies reported contradictory results for the prognostic significance of a pathological fracture in osteosarcoma patients. The aim of this study is to report the outcomes for a cohort of patients with osteosarcoma who presented with and without pathological fractures and to identify the prognostic importance of pathological fracture in predicting outcomes and influences on survival. METHODS: Data of patients with osteosarcoma were retrospectively reviewed...
December 28, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28009431/up-regulation-of-long-noncoding-rna-ccal-predicts-poor-patient-prognosis-and-promotes-tumor-metastasis-in-osteosarcoma
#16
Da-Kai Zhou, Xi-Wang Yang, Huining Li, Yongbo Yang, Zhen-Jun Zhu, Na Wu
BACKGROUND: Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. Aberrant colorectal cancer-associated lncRNA (CCAL) has been found in colorectal cancer. However, the function of lncRNA CCAL in osteosarcoma (OS) remains unclear. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure CCAL expression in OS tissues and adjacent nontumor tissues. The correlation betweent CCAL expression and clinicopathological features and prognosis was also analyzed...
December 22, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28008378/association-of-circulating-mir-125b-and-survival-in-patients-with-osteosarcoma-a-single-center-experience
#17
Zhiqiang Luo, Minglu Liu, Haihong Zhang, Yayi Xia
BACKGROUND: It is known that miRNAs play various roles in malignant tumors. This study is designed to investigate whether miR-125b levels can be used to predict the clinical response of patients with osteosarcoma (OS) to cisplatin-based chemotherapy. METHODS: From January 2010 to July 2015, 82 patients with resectable OS and 56 patients with unresectable OS were enrolled. Blood samples were collected and quantitative real-time PCR was applied to determine miR-125b expression...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28002586/correlation-between-trail-and-caspase-8-expression-and-their-relationship-with-cell-proliferation-and-apoptosis-in-human-osteosarcoma
#18
X Ning, X W Shang, Y Zhuang, M Liu, H Yang, H Zhang, M Z Huang
Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with cell proliferation and apoptosis. Osteosarcoma and osteochondroma patients receiving surgery in our hospital were selected...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27994653/association-of-common-variants-in-mtap-with-susceptibility-and-overall-survival-of-osteosarcoma-a-two-stage-population-based-study-in-han-chinese
#19
Liqiang Zhi, Dan Liu, Stephen G Wu, Tianqing Li, Guanghui Zhao, Bo Zhao, Meng Li
Osteosarcoma (OS) is a common malignant tumor, which exists widely in the bone of children and adolescents, and genetic factors may influence its susceptibility. Recently, the gene MTAP has been reported to be associated with OS in a Caucasian population. To investigate the association of common variants in MTAP with OS risk in Han Chinese individuals, we designed a two-stage case-control study with 392 OS patients and 1,578 unrelated healthy controls of Han Chinese individuals. A total of 17 tagging single nucleotide polymorphisms (SNPs) were firstly genotyped in the discovery stage, and single-SNP association and haplotypic association analyses have been performed...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27922432/mir-21-predicts-poor-prognosis-in-patients-with-osteosarcoma
#20
Xianfeng Ren, Yuqin Shen, Shuyun Zheng, JianYong Liu, Xin Jiang
BACKGROUND AND AIMS: miR-21 has been demonstrated to play an important role in tumour progression. The aim of the present study was to analyse the correlation between miR-21 expression level and clinicopathologic features, as well as to assess the prognostic significance of miR-21 in osteosarcoma. METHODS: Eighty-four pairs of osteosarcoma and corresponding non-cancerous bone tissues were obtained, and miR-21 expression levels were detected using quantitative real-time PCR (qRT-PCR)...
October 2016: British Journal of Biomedical Science
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