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osteosarcoma staging

Xiaojuan Zhang, Zhe Guan
Osteosarcoma is an aggressive malignancy that usually occurs in children and young adults, and long-term survival is only about 20% in patients with metastasis or recurrent disease. Traditional non-invasive techniques, such as positron-emission tomography (PET) scanning, magnetic resonance imaging (MRI) or computed tomography (CT) scanning, may not identify single lesions in the early stage or accurately detect small lesions. A novel technique, positron emission tomography/computed tomography (PET/CT), which is widely used in clinical practice, shows more accuracy, sensitivity, and specificity in the diagnosis of osteosarcoma...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
Z-X Chen, C-P Chen, N Zhang, T-X Wang
OBJECTIVE: To investigate the potential role of Long non-coding RNA (lncRNA) FER1L4 in the diagnosis and prognostic assessment of osteosarcoma. PATIENTS AND METHODS: LncRNA FER1L4 expression in osteosarcoma samples was detected by real-time PCR. The Kaplan-Meier method was used to analyze the relationship between lncRNA FER1L4 expression and the survival time of patients. RESULTS: LncRNA FER1L4 expression was decreased in osteosarcoma samples...
April 2018: European Review for Medical and Pharmacological Sciences
Jinyang Wang, Lei Zhang, Rongmei Qu, Lin Zhang, Wenhua Huang
Osteosarcoma, the most common primary bone tumor, occurs most frequently in children and adolescents and has a 5-year survival rate, which is unsatisfactory. As epidermal growth factor receptor (EGFR) positively correlates with TNM (tumor-node-metastasis) stage in osteosarcoma, EGFR may play an important role in its progression. The purpose of this study was to explore potential mechanisms underlying this correlation. We found that EGF promotes MG63 cell migration and invasion as well as stress fiber formation via Rho A activation and that these effects can be reversed by inhibiting Rho A expression...
May 11, 2018: International Journal of Molecular Sciences
Yucheng Fu, Tao Lan, Hongliu Cai, Anwei Lu, Wei Yu
BACKGROUNDS: A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcoma patients. METHODS: We performed the systematic computerized search for eligible articles from PubMed, Embase, and Cochrane databases until December 21, 2017...
May 2018: Medicine (Baltimore)
Ming Qian, Haiyi Gong, Xinghai Yang, Jian Zhao, Wangjun Yan, Yan Lou, Dongyu Peng, Zhenxi Li, Jianru Xiao
Osteosarcoma (OS) is the most common type of primary bone tumor and accounts for ~60% of all malignant bone tumors in children and adolescents. A large number of studies have proposed that the dysregulated and dysfunctional microRNAs may serve important roles in the occurrence, progression and metastasis of various types of human cancer, including OS. MicroRNA-493 (miR-493) has been identified to act as a tumor suppressor in several types of human cancer. However, little is known regarding the expression pattern and clinical significance of miR-493 in OS...
May 2018: Oncology Letters
Gang Hou, Biying Chen, Wenbin Xu, Huiqing Zhao, Kaihua Liu, Hui Yao
The aim of the present study was to investigate the expression of cell division cycle gene 2 ( CDC2 ) in osteosarcoma tissues and its clinical significance. Specimens of cancer tissues, paracancerous tissues and serum from 47 patients hospitalized at the Department of Orthopedics at The Third Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) from January, 2010 to January, 2015 and serum from 35 normal subjects were collected. The expression of CDC2 mRNA was evaluated using quantitative polymerase chain reaction (RT-PCR) and the relationship between CDC2 protein expression and clinical features of patients with osteosarcoma was analyzed...
May 2018: Oncology Letters
Justin M M Cates
Both the American Joint Committee on Cancer (AJCC) and Musculoskeletal Tumor Society (MSTS) staging systems for skeletal sarcomas have major weaknesses. A revised staging system for osteosarcoma (the Vanderbilt system) was developed based on exploratory analyses of the relative prognostic impacts of histologic grade, tumor size, local tumor extension, and specific anatomic sites of metastasis using case records from the National Cancer Database (N = 4,285). AJCC, MSTS, and Vanderbilt staging schemes were then compared using a separate, population-based cancer registry (the Surveillance, Epidemiology, and End Results database; N = 2,246) as a validation dataset...
May 2, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jian Tu, Lili Wen, Zijun Huo, Bo Wang, Yongqian Wang, Hongyi Liao, Weihai Liu, Xian Zhong, Jianqiu Kong, Mengqi Wang, Gang Huang, Junqiang Yin, Xianbiao Xie, Jingnan Shen
BACKGROUND: We aimed to investigate the roles of hemoglobin (Hb) concentrations and dynamic change during treatment on outcomes of patients with extremity osteosarcoma. METHODS: We retrospectively analysed 133 patients with Enneking stage IIB extremity osteosarcoma who underwent standard treatments, including univariate and multivariate analyses of patient charateritics, Hb concentrations and changes during pretreatment, neoadjuvant, adjuvant chemotherapy, and decreased Hb levels (ΔHb) to assess their prognostic value in 5-year overall survival (OS) and lung metastasis-free survival (LMFS)...
April 16, 2018: BMC Cancer
Amirhossein Misaghi, Amanda Goldin, Moayd Awad, Anna A Kulidjian
Osteosarcoma (OS) is a relatively rare tumor of bone with a worldwide incidence of 3.4 cases per million people per year. For most of the twentieth century, five-year survival rates for classic OS were very low. In the 1970s, the introduction of adjuvant chemotherapy in the treatment of OS increased survival rates dramatically. The current article reviews the various types of OS and analyzes the clinical and histological features. We also examine historical and current literature to present a succinct review of methods for diagnosis and staging, as well as treatment, and we also discuss some of the future directions of treatment...
2018: SICOT-J
Riliang Cao, Jianli Shao, Yabin Hu, Liang Wang, Zhizhong Li, Guodong Sun, Xiaoliang Gao
Background: Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of miR-338-3p in OS cells. Methods: qRT-qPCR was performed to quantify miR-338-3p expression levels in OS tissue samples and in three common OS cell lines. MG-63 and Saos2 cells were separately transfected with miR-338-3p or NC mimics and miR-338-3p expression levels was determined by qRT-PCR...
2018: Cancer Cell International
Longlong Zheng, Nan Hu, Guoyi Guan, Jialin Chen, Xiaozhong Zhou, Maoquan Li
The effects of long non-coding RNAs (lncRNAs) on cellular biological processes and even the tumorigenesis have been widely reported. Small nucleolar RNA host gene 6 (SNHG6) has been reported to participate in regulating biological behaviors of multiple types of cancers. Nevertheless, the functions of SNHG6 in osteosarcoma still remain to be uncovered. This study intended to determine the clinical significance and biological functions of SNHG6 in osteosarcoma. It was confirmed by qRT-PCR that SNHG6 was highly expressed in osteosarcoma tissues and cell lines...
March 30, 2018: Archives of Biochemistry and Biophysics
Hugo Garcia, Véronique Leblond, François Goldwasser, Didier Bouscary, Emmanuel Raffoux, Nicolas Boissel, Sophie Broutin, Dominique Joly
INTRODUCTION: High-dose methotrexate (at least 1g/m2 ) is used to treat haematologic malignancies and osteosarcomas. Acute kidney injury is a well-known adverse-event after high-dose methotrexate and may lead to delayed drug elimination. Besides usual therapeutics (hyperhydration, urine alkalinisation, leucovorin rescue, renal replacement therapy), a costly specific enzymatic treatment (glucarpidase) is now available but its clinical impact remains elusive. PATIENTS AND METHODS: We analysed high-dose methotrexate prescription charts in 11 clinical centres during the last 15 years to identify and describe adult patients who developed acute kidney injury (according to KDIGO classification)...
April 2018: Néphrologie & Thérapeutique
Jingzhe Zhang, Li Kai, Wenlong Zhang, Yu Yin, Wenjun Wang
Osteosarcoma (OS) is one of the most common bone malignancies in children and adolescents. To date, inaugural mechanism of OS was considered as a complex process and was still not clear. The p53 gene, most important tumor suppressors, was associated with risk of many tumors, including OS. In current study, we evaluated the relationship between genetic variation of the p53 binding site and the OS susceptibility through a two-stage case-control study in Chinese population. We found that rs1295925 (OR = 0.85; 95 CI = 0...
March 29, 2018: Cancer Biology & Therapy
Jun Wan, Can Zhang, Hong-Bo He
BACKGROUND: Resection of proximal fibular osteosarcoma involving the posteromedial aspect of the fibula is challenging. Reconstruction using a gastrocnemius flap may result in significant lateral instability and abnormal knee movement. Furthermore, postoperative gait may be disturbed by foot drop resulting from scarification of the common peroneal nerve. METHODS: Between January 2011 and December 2013, five patients with proximal fibular osteosarcoma were treated via the double-approach procedure using en bloc resection without a gastrocnemius flap...
March 27, 2018: World Journal of Surgical Oncology
Yang Qu, Shuang Zheng, Mingyang Kang, Rongpeng Dong, Haohan Zhou, Dezhi Zhao, Jianwu Zhao
Long non-coding RNA HOXD-AS1 (HOXD-AS1) has recently been shown to be involved in the development and progression of multiple cancers. However, the expression, significance, and biological function of HOXD-AS1 in osteosarcoma (OS) remain unknown. Here, we found that the expression level of HOXD-AS1 was significantly upregulated in OS tissues and cells. Furthermore, high expression of HOXD-AS1 was positively associated with the clinical and pathological characteristics of OS, including tumor stage and lymph node metastasis, and negatively correlated with overall survival rate...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Huaiyuan Xu, Xiaojun Zhu, Hua Bao, Tony Wh Shek, Zongwen Huang, Yongqian Wang, Xue Wu, Yong Wu, Zhili Chang, Shuyu Wu, Qinglian Tang, Huizhong Zhang, Anjia Han, Kenneth Mc Cheung, Changye Zou, Raymond Yau, Wai-Yip Ho, Gang Huang, Sellma Batalha, Jinchang Lu, Guohui Song, Yao Kang, Yang W Shao, Ying Lee Lam, Jingnan Shen, Jin Wang
Osteosarcoma is a primary malignant bone tumor that has a high potential to metastasize to lungs. Little is known about the mechanisms underlying the dissemination of OS cancer cells to lungs. We performed whole exome sequencing of 13 OS primary tumors, with matched lung metastases and normal tissues. Phylogenetic analyses revealed that lung metastatic tumors often harbor clones that are nonexistent or rare in the matched primary OS tumors. Spatially and temporally separated lung metastases were from parallel seeding events with a polyphyletic pattern...
March 23, 2018: International Journal of Cancer. Journal International du Cancer
Tao Guo, Guobiao Pan
BACKGROUND: Accumulating studies have reported the abnormal expression of microRNA-136 (miR-136) in numerous types of human cancer, and its involvement in cancer initiation and progression. However, there are no investigations of miR-136 in osteosarcoma (OS). OBJECTIVE: To explore the expression pattern, clinical significance and potential roles of miR-136 in OS. METHODS: miR-136 expression in clinical OS tissues and human OS cell lines were detected by qPCR, and its associations with clinicopathological characteristics of OS patients were statistically analyzed...
March 2, 2018: Cancer Biomarkers: Section A of Disease Markers
Sara Pagotto, Angelo Veronese, Alessandra Soranno, Paola Lanuti, Mirco Di Marco, Marco Vincenzo Russo, Alice Ramassone, Marco Marchisio, Pasquale Simeone, Paolo E Guanciali Franchi, Giandomenico Palka, Renato Mariani Costantini, Carlo M Croce, Rosa Visone
Hsa-miR-155-5p (miR-155) is overexpressed in most solid and hematological malignancies. It promotes loss of genomic integrity in cancer cells by targeting genes involved in microsatellite instability and DNA repair; however, the link between miR-155 and aneuploidy has been scarcely investigated. Here we describe a novel mechanism by which miR-155 causes chromosomal instability. Using osteosarcoma cells (U2OS) and normal human dermal fibroblast (HDF), two well-established models for the study of chromosome congression, we demonstrate that miR-155 targets the spindle checkpoint proteins BUB1, CENP-F, and ZW10, thus compromising chromosome alignment at the metaphase plate...
February 27, 2018: Oncotarget
Jun Liu, Lei Huang, Pengxiao Su, Tao Song, Wentao Zhang, Jinzhu Fan, Yang Liu
A number of studies have attempted to elucidate the association between mircoRNAs (miRNAs/miRs) and cancer-associated processes. The aim of the present study was to determine how miR-499a-5p intervenes in human osteosarcoma cell proliferation and differentiation. The cancerous tissues and adjacent non-cancerous tissues of 62 patients with osteosarcoma (OS) were collected. miRNA microarray analysis revealed that 29 miRNAs were upregulated while 26 were downregulated, among which miR-499a-5p expression was the most decreased...
April 2018: Oncology Letters
Yunxing Zhang, Wang Meng, Hongxia Cui
LncRNA CBR3-AS1 has been suggested to promote malignancy in several types of human cancers, but the clinical significance and biological function of lncRNA CBR3-AS1 in osteosarcoma is still unknown. The purpose of our study is to explore the clinical significance of lncRNA CBR3-AS1 in osteosarcoma patients and the biological function in osteosarcoma cells. In our results, we found lncRNA CBR3-AS1 was highly-expressed in osteosarcoma tissues and cell lines, and associated with Enneking stage, distant metastasis and histological grade...
March 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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