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osteosarcoma staging

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https://www.readbyqxmd.com/read/28280610/investigation-of-the-human-h3-3b-h3f3b-gene-expression-as-a-novel-marker-in-patients-with-colorectal-cancer
#1
Habib Allah Ayoubi, Frouzandeh Mahjoubi, Rezvan Mirzaei
BACKGROUND: H3.3 histone is a replacement histone subtype that is express in entire cell cycle phases and overexpress in transcriptionally active regions, promoter regions, and intergenic or intragenic regulatory elements. This histone encoded by two genes termed H3.3A (H3F3A) and H3.3B (H3F3B). Mutations of these two genes lead to some human cancers such as chondroblastoma, osteosarcoma, and epithelial ovarian cancer. The aims of this study were to quantitatively examine the expression of H3...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28277189/cxcl5-plays-a-promoting-role-in-osteosarcoma-cell-migration-and-invasion-in-autocrine-and-paracrine-dependent-manners
#2
Hongsheng Dang, Wuzhou Wu, Bo Wang, Cao Cui, Juwei Niu, Jie Chen, Ziqiu Chen, Yi Liu
CXCL5, a CXC-type chemokine, is an important attractant for granulocytic immune cells by binding to its receptor CXCR2. Recently, CXCL5/CXCR2 has been found to play an oncogenic role in many human cancers. However, the exact role of CXCL5 in osteosarcoma cell migration and invasion has not been revealed. Here we found that the protein expression of CXCL5 was significantly increased in osteosarcoma tissues compared with that in matched adjacent nontumor tissues. Moreover, the expression of CXCL5 was significantly associated with advanced clinical stage and metastasis...
January 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28272712/the-expression-and-function-of-mirna-106-in-pediatric-osteosarcoma
#3
M Xu, Y-Y Zhang, H-F Wang, G-S Yang
OBJECTIVE: This study is to investigate the expression and biological function of miRNA-106b in osteosarcoma. PATIENTS AND METHODS: Freshly resected osteosarcoma tissues and the corresponding para-carcinoma tissues were collected from 54 patients. Then miR-106b level in the carcinoma tissues was detected by real-time PCR. To test the function of miR-106b, osteosarcoma cell line U2-OS was transfected with miR-106b inhibitor in vitro. Then, the proliferation, cell cycle, invasion and metastasis of U2-OS cells were detected by CCK-8 assay, flow cytometry, and transwell respectively...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28260104/mir-92a-promotes-tumor-growth-of-osteosarcoma-by-targeting-pten-akt-signaling-pathway
#4
Jie Xiao, Weifeng Yu, Kongzu Hu, Maoqiang Li, Jianwei Chen, Zhanchun Li
MicroRNAs (miRNAs) play critical roles in human cancers including osteosarcoma (OS). miR-92a has been found to be a cancer-related miRNA in many cancer types and it is upregulated in OS cell lines. However, the expression and biological function of miR-92a in OS have not been investigated. In this study, we showed that miR-92a expression was increased in OS tissues, and its high expression was correlated with clinical stage, T classification and histological differentiation. Furthermore, patients with high expression of miR-92a had a significantly poorer survival rate...
March 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28260090/actin-like-protein-6a-is-a-novel-prognostic-indicator-promoting-invasion-and-metastasis-in-osteosarcoma
#5
Wei Sun, Wanchun Wang, Jian Lei, Hui Li, Yi Wu
Osteosarcoma harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. Actin-like protein 6A (ACTL6A) regulates cell proliferation, migration and differentiation. However, the biologic role of ACTL6A in osteosarcoma remains unknown. In this study, the results showed that, by analysis of frozen fresh primary tumor tissues, matched non-cancerous bone tissues (NCBTs) and biopsy lung metastatic nodule tissues from 30 osteosarcoma patients after radical surgical resection, ACTL6A was overexpressed in osteosarcoma tissues compared with matched NCBTs, and its expression level was associated with osteosarcoma metastasis...
February 23, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28249982/staged-lengthening-and-reconstruction-for-children-with-a-leg-length-discrepancy-after-excision-of-an-osteosarcoma-around-the-knee
#6
S Kang, J S Lee, J Park, S-S Park
AIMS: Children treated for osteosarcoma around the knee often have a substantial leg-length discrepancy at skeletal maturity. The aim of this study was to investigate the results of staged skeletal reconstruction after a leg lengthening procedure using an external fixator in these patients. PATIENTS AND METHODS: We reviewed 11 patients who underwent staged reconstruction with either an arthroplasty (n = 6) or an arthrodesis (n = 5). A control group of 11 patients who had undergone wide excision and concurrent reconstruction with an arthroplasty were matched for gender, location, and size of tumour...
March 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28244849/microrna-373-promotes-growth-and-cellular-invasion-in-osteosarcoma-cells-by-activation-of-pi3k-akt-rac1-jnk-pathway-the-potential-role-in-spinal-osteosarcoma
#7
Yufeng Liu, Zhengliang Cheng, Feng Pan, Weigang Yan
Spinal osteosarcoma (OS) has been proved more difficult to treat owing to potently malignant metastasis. The present study was aimed to explore functional role of microRNA (miR)-373 in cell growth and cellular invasion of OS cells, as well as its underlying mechanism. Expressions of miR-373 were analyzed in spinal OS tissues and cell lines. MG-63 cells were transfected with miR-373 mimic or inhibitor and/or treated with the inhibitor of phosphoinositide 3-kinase (PI3K) (LY294002) or the inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac) guanosine triphosphate (GTPase) (NSC23766), and then the of miR-373 aberrant expression on cell growth and cellular invasion were measured, along with the impacts of overexpressing miR-373 on expression of p53 and PI3K/AKT pathway related proteins...
December 15, 2016: Oncology Research
https://www.readbyqxmd.com/read/28239821/analysis-of-circulating-long-non-coding-rna-uca1-as-potential-biomarkers-for-diagnosis-and-prognosis-of-osteosarcoma
#8
J-J Wen, Y-D Ma, G-S Yang, G-M Wang
OBJECTIVE: The aim of this investigation was to examine the potential usefulness of long non-coding RNA UCA1 (UCA1) as a biomarker for diagnosis and prognosis in osteosarcoma. PATIENTS AND METHODS: The expression level of UCA1 was determined using TaqMan real-time PCR in human osteosarcoma tissues and patients' sera. Next, we investigated to clarify the relationship of UCA1 with clinicopathological features. The receiver operating characteristic (ROC) curve was performed to estimate the diagnostic value of UCA1...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28224623/outcome-and-prognostic-factors-following-curative-intent-surgery-for-oral-tumours-in-dogs-234-cases-2004-to-2014
#9
B N Sarowitz, G J Davis, S Kim
OBJECTIVES: To describe the long-term outcomes and prognostic factors associated with curative-intent surgery for oral tumours in a large series of dogs. METHODS: Retrospective review of records for dogs with oral tumours treated with curative-intent surgery. Data collected included signalment, weight, surgical procedure, lymph node staging results, computed tomography results, tumour size, histopathology results including margin evaluation, complications, adjunctive therapies, local recurrence or metastasis, date and cause of death and owner satisfaction...
February 22, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28223819/the-clinical-significance-of-the-ezrin-gene-and-circulating-tumor-cells-in-osteosarcoma
#10
Guang-Xian Zhong, Shao-Dan Feng, Rongkai Shen, Zhao-Yang Wu, Fei Chen, Xia Zhu
PURPOSE: The aim of this study was to investigate the clinical significance of circulating tumor cells (CTCs) in the peripheral blood of an osteosarcoma and the Ezrin gene expressed in CTCs. PATIENTS AND METHODS: CTC enrichment was done with CanPatrol™ CTC enrichment technique in 41 patients with osteosarcoma. The characterization of CTCs was performed using a multiple messenger RNA in situ analysis (MRIA). The expression of the Ezrin gene in CTCs was detected by RNA probe technology...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28214202/elevated-expression-of-microrna-19a-predicts-a-poor-prognosis-in-patients-with-osteosarcoma
#11
Pingzhou Zou, Jian Ding, Shiping Fu
MicroRNA (miR)-19a, a member of the miR-17-92 cluster, functions as an oncomiRNA in multiple kinds of cancers. However, its involvement in human osteosarcomas remains unclear. In this study, to analyze the expression pattern of miR-19a and to investigate its clinical implication in human osteosarcomas, quantitative reverse-transcription polymerase chain reaction was performed to detect expression levels of miR-19a in 166 self-pairs of osteosarcoma and noncancerous bone tissues. Associations between miR-19a expression and various clinicopathological parameters and patients' prognosis of osteosarcomas were further evaluated...
December 29, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28196121/prognostic-significance-of-chemotherapy-induced-necrosis-in-osteosarcoma-patients-receiving-pasteurized-autografts
#12
Min Wook Joo, Yong Koo Kang, Chang-Young Yoo, Sung Ho Cha, Yang-Guk Chung
BACKGROUND: Among various reconstruction methods after wide excision for osteosarcoma, pasteurized autograft is often preferred. While the whole area of the tumor can be assessed for chemotherapy-induced necrosis, one of the important prognostic factors, in other reconstructive techniques, only a portion removed from a wide-resection specimen is available when using pasteurized autograft method. The assessment, therefore, may be unreliable. We analyzed the prognostic significance of the chemotherapy-induced necrosis in osteosarcoma patients who underwent reconstruction with pasteurized autografts...
2017: PloS One
https://www.readbyqxmd.com/read/28195881/comparison-of-the-ajcc-msts-and-modified-spanier-systems-for-clinical-and-pathologic-staging-of-osteosarcoma
#13
Justin M M Cates
The prognostic performance of the 2 most commonly used staging systems for skeletal sarcoma (the American Joint Committee on Cancer [AJCC] and Musculoskeletal Tumor Society [MSTS] systems) have never been compared analytically. Another staging system originally proposed by Spanier has not yet been validated. Given the recent release of the 8th edition of the AJCC Cancer Staging Manual, this study was designed to directly compare these anatomic staging systems in a series of 153 high-grade, intramedullary osteosarcomas...
March 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28194714/is-limb-salvage-with-microwave-induced-hyperthermia-better-than-amputation-for-osteosarcoma-of-the-distal-tibia
#14
Kang Han, Peiye Dang, Na Bian, Xiang Chen, Tongtao Yang, QingYu Fan, Yong Zhou, Tingbao Zhao, Pingshan Wang
BACKGROUND: Amputation has been the standard surgical treatment for distal tibia osteosarcoma owing to its unique anatomic features. Preliminary research suggested that microwave-induced hyperthermia may have a role in treating osteosarcoma in some locations of the body (such as the pelvis), but to our knowledge, no comparative study has evaluated its efficacy in a difficult-to-treat location like the distal tibia. QUESTIONS: Does microwave-induced hyperthermia result in (1) improved survival, (2) decreased local recurrence, (3) improved Musculoskeletal Tumor Society (MSTS) scores, or (4) fewer complications than amputation in patients with a distal tibial osteosarcoma? METHODS: Between 2000 and 2015, we treated 79 patients for a distal tibia osteosarcoma without metastases...
February 13, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28188704/cnot1-cooperates-with-lmna-to-aggravate-osteosarcoma-tumorigenesis-through-the-hedgehog-signaling-pathway
#15
Dong-Dong Cheng, Jing Li, Shi-Jie Li, Qing-Cheng Yang, Cun-Yi Fan
While treatments for childhood osteosarcoma have improved, the overall survival for this common type of bone cancer has not changed for three decades, and thus, new targets for therapeutic development are needed. To identify tumor-related proteins in osteosarcoma, we used isobaric tags in a relative and absolute quantitation proteomic approach to analyze the differentially expressed proteins between osteosarcoma cells and human osteoblastic cells. Through clinical screening and functional evaluation, CCR4-NOT transcription complex subunit 1 (CNOT1) correlated with the growth of osteosarcoma cells...
February 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28165565/decreased-expression-of-mir-490-3p-in-osteosarcoma-and-its-clinical-significance
#16
B Tang, C Liu, Q-M Zhang, M Ni
OBJECTIVE: Increasing evidence has revealed that miRNAs play a key role in the development and progression of tumor and are being explored as a prognostic biomarker. The aim of this study was to investigate the clinical significance of miR-490-3p expression in osteosarcoma. PATIENTS AND METHODS: Quantitative real-time PCR (qRT-PCR) was used to evaluate miR-490-3p level in osteosarcoma tissues. We also analyzed the correlations between the expression level of miR-490-3p and the clinical characteristics in cases of osteosarcoma...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28163298/correlations-between-hector-battifora-mesothelial-1-hbme-1-expression-and-clinical-pathological-characteristics-and-prognosis-of-osteosarcoma-patients
#17
Yu-Xin Zhao, Song-Tao Gao, Jia-Qiang Wang, Wei-Tao Yao, Yi-Sheng Wang, Cai-Li Guo
BACKGROUND The aim of this study was to investigate the correlation between Hector Battifora mesothelial-1 (HBME-1) expression and the clinical pathological characteristics and prognosis of osteosarcoma (OS). MATERIAL AND METHODS HBME-1 expression was assessed using immunohistochemistry in OS tissues (n=152), osteochondroma tissues (n=91), and normal bone tissues (n=74). We carried out a follow-up lasting 8-60 months to investigate HBME-1 expression and its correlations with the clinical pathological characteristics and prognosis of OS...
February 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28108312/ctgf-promotes-osteosarcoma-angiogenesis-by-regulating-mir-543-angiopoietin-2-signaling
#18
Li-Hong Wang, Hsiao-Chi Tsai, Yu-Che Cheng, Chih-Yang Lin, Yuan-Li Huang, Chun-Hao Tsai, Guo-Hong Xu, Shih-Wei Wang, Yi-Chin Fong, Chih-Hsin Tang
Osteosarcoma is the most common primary solid tumor of bone. It has a high metastatic potential and occurs predominantly in adolescents and young adults. Angiopoietin 2 (Angpt2) is a key regulator in tumor angiogenesis, facilitating tumor growth and metastasis. Connective tissue growth factor (CTGF, also known as CCN2), is a cysteine-rich protein that has been reported to promote metastasis of osteosarcoma. However, the effect of CTGF on Angpt2 regulation and angiogenesis in human osteosarcoma remains largely unknown...
January 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28103887/microrna-expression-patterns-and-signalling-pathways-in-the-development-and-progression-of-childhood-solid-tumours
#19
REVIEW
Anna L Leichter, Michael J Sullivan, Michael R Eccles, Aniruddha Chatterjee
The development of childhood solid tumours is tied to early developmental processes. These tumours may be complex and heterogeneous, and elucidating the aberrant mechanisms that alter the early embryonic environment and lead to disease is essential to our understanding of how these tumours function. MicroRNAs (miRNAs) are vital regulators of gene expression at all stages of development, and their crosstalk via developmental signalling pathways is essential for orchestrating regulatory control in processes such as proliferation, differentiation and apoptosis of cells...
January 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28077810/increased-expression-of-long-non-coding-rna-bcar4-is-predictive-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#20
Jianhua Gong, Han Zhang, Li He, Lixin Wang, Jipeng Wang
Lung cancer is the most common human cancer, and the majority of lung cancer cases are categorized as non-small cell lung cancer (NSCLC). Long non-coding RNAs (lncRNAs) play key roles in the development and progression of human cancers. LncRNA breast cancer anti-estrogen resistance 4 (BCAR4) has been identified as an oncogenic lncRNA involved in the progression of breast cancer and osteosarcoma. However, the clinical significance of the lncRNA BCAR4 in NSCLC remains largely unclear. In the present study, real-time quantitative reverse transcriptase-polymerase chain reaction was used to examine the relative level of lncRNA BCAR4 in 68 cases of NSCLC tissues and their adjacent non-tumor tissues...
2017: Tohoku Journal of Experimental Medicine
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