keyword
https://read.qxmd.com/read/38504661/synchronous-low-grade-central-osteosarcoma-and-ewing-sarcoma-a-rare-case-report
#1
JOURNAL ARTICLE
Daniel Christensen, Jeffrey A Belair, Atrayee BasuMallick, Scot A Brown, Michael Klein, Wei Jiang
A 23-year-old female patient presented with radicular back pain, perineal numbness, and urinary retention. The patient was diagnosed with cauda equina syndrome and magnetic resonance imaging (MRI) of the spine revealed an enhancing osseous lumbar lesion causing severe central stenosis. A core needle biopsy of the lumbar spine showed microscopic features compatible with a small round blue cell tumor. CD99 and FLI1 were positive in the tumor cells. Next-generation sequencing demonstrated a EWSR1::FLI1 fusion...
March 20, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38502871/intraoperative-resection-guidance-and-rapid-pathological-diagnosis-of-osteosarcoma-using-b7h3-targeted-probe-under-nir-ii-fluorescence-imaging
#2
JOURNAL ARTICLE
Fanwei Zeng, Changjian Li, Han Wang, Yueqi Wang, Tingting Ren, Fangzhou He, Jie Jiang, Jiuhui Xu, Boyang Wang, Yifan Wu, Yiyang Yu, Zhenhua Hu, Jie Tian, Shidong Wang, Xiaodong Tang
Complete removal of all tumor tissue with a wide surgical margin is essential for the treatment of osteosarcoma (OS). However, it's difficult, sometimes impossible, to achieve due to the invisible small satellite lesions and blurry tumor boundaries. Besides, intraoperative frozen-section analysis of resection margins of OS is often restricted by the hard tissues around OS, which makes it impossible to know whether a negative margin is achieved. Any unresected small tumor residuals will lead to local recurrence and worse prognosis...
March 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38488967/does-the-presence-of-macroscopic-intralesional-fat-exclude-malignancy-an-analysis-of-613-histologically-proven-malignant-bone-lesions
#3
JOURNAL ARTICLE
Eddy D Zandee van Rilland, Se-Young Yoon, Hillary W Garner, Jennifer Ni Mhuircheartaigh, Jim S Wu
OBJECTIVE: To determine if macroscopic intralesional fat detected in bone lesions on CT by Hounsfield unit (HU) measurement and on MRI by macroscopic assessment excludes malignancy. MATERIALS AND METHODS: All consecutive CT-guided core needle biopsies (CNB) of non-spinal bone lesions performed at a tertiary center between December 2005 and September 2021 were reviewed. Demographic and histopathology data were recorded. All cases with malignant histopathology were selected, and imaging studies were reviewed...
March 15, 2024: European Radiology
https://read.qxmd.com/read/38449944/diagnosis-and-current-treatment-of-aneurysmal-bone-cysts
#4
REVIEW
Khalid A Bakarman
The purpose of this review is to increase awareness about the evolution and development of current trends in the diagnosis and treatment of aneurysmal bone cysts (ABCs). ABCs are benign, but locally aggressive bone tumors that mainly affect children. ABCs comprise 1% of all primary bone tumors and occur most frequently during the first two decades of life. The diagnosis is made using a variety of imaging modalities and has the characteristic features of an expansile, radiolucent lesion that is often seen in the metaphyseal region of the bone and has fluid-fluid levels that are apparent on MRI...
February 2024: Curēus
https://read.qxmd.com/read/38431083/desmoplastic-fibroma-of-the-jaw-a-case-report-and-review-of-the-literature
#5
Tancrède Segard, Hélios Bertin, Charles Lepine, Pierre Guyonvarc'h
Desmoplastic fibroma (DF) is a rare benign bone tumor adopting an aggressive behavior, representing a challenge for clinical and radiographic diagnosis. This case report focused on a 31-year-old man with a large mandibular lesion with severe displacements of the mandibular teeth. Only a combination of paraclinical findings allows a definitive diagnosis to be made. Cervicofacial MRI revealed a low T1 signal intensity with peripheral enhancement after Gadolinium, and T2 hyperintense signal, while PET scan showed a moderate metabolism...
February 29, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38430473/use-of-modern-three-dimensional-imaging-models-to-guide-surgical-planning-for-local-control-of-pediatric-extracranial-solid-tumors
#6
JOURNAL ARTICLE
Nikhil R Shah, William J Weadock, Keyonna M Williams, Rebecca Moreci, Tammy Stoll, Aparna Joshi, Robin Petroze, Erika A Newman
INTRODUCTION: In complex pediatric surgical oncology, surgical planning is contingent upon data gathered from preoperative imaging. Three-dimensional (3D) modeling and printing has been shown to be beneficial for adult presurgical planning, though pediatric literature is less robust. The study reviews our institutional experience with the use of 3D image segmentation and printed models in approaching resection of extracranial solid tumors in children. METHODS: This is a single institutional series from 2021 to 2023...
March 2, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38408127/comparative-analysis-of-skip-metastasis-in-pediatric-osteosarcoma-clinical-features-and-outcomes
#7
JOURNAL ARTICLE
Hadeel Halalsheh, Shrouq Amer, Zaid Omari, Munir Shawagfeh, Mohammad Boheisi, Iyad Sultan
BACKGROUND: Skip metastasis (SM) is a synchronous regional bone metastasis. Using new imaging modalities, the detection of SM is easier and possibly more common. We reviewed patients with SM and compared their characteristics and outcomes to other patients with osteosarcoma treated at our center. METHODS: We reviewed retrospectively children (<18 years) with newly diagnosed osteosarcoma who presented from June 2006 to March 2022. Patients' characteristics, treatment modalities, and outcomes were analyzed...
February 19, 2024: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/38345039/the-significance-of-surveillance-imaging-in-children-with-ewing-sarcoma-and-osteosarcoma
#8
JOURNAL ARTICLE
Scott Greve Brekke, Arne Lucke, Henrik Hasle, Thomas Baad-Hansen
Primary bone tumors in children and adolescents, while rare, pose significant challenges in diagnosis and management. Children treated for Ewing sarcoma and osteosarcoma are offered a 5-year follow-up program after end of treatment, including radiological surveillance of primary location of tumor and the lungs. There is no consensus regarding how often and how the children should be followed with radiological imaging. This retrospective descriptive study of 69 patients (34 with Ewing sarcoma and 35 with osteosarcoma) investigated the consequences of abnormal findings in 1279 follow-up images...
February 12, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38323317/a-novel-approach-to-guide-gd2-targeted-therapy-in-pediatric-tumors-by-pet-and-64-cu-cu-nota-ch14-18-cho
#9
JOURNAL ARTICLE
Nils Florian Trautwein, Johannes Schwenck, Christian Seitz, Ferdinand Seith, Eduardo Calderón, Sebastian von Beschwitz, Stephan Singer, Gerald Reischl, Rupert Handgretinger, Jürgen Schäfer, Peter Lang, Bernd J Pichler, Johannes H Schulte, Christian la Fougère, Helmut Dittmann
Background: The tumor-associated disialoganglioside GD2 is a bona fide immunotherapy target in neuroblastoma and other childhood tumors, including Ewing sarcoma and osteosarcoma. GD2-targeting antibodies proved to be effective in neuroblastoma and GD2-targeting chimeric antigen receptors (CAR)- expressing T cells as well as natural killer T cells (NKTs) are emerging. However, assessment of intra- and intertumoral heterogeneity has been complicated by ineffective immunohistochemistry as well as sampling bias in disseminated disease...
2024: Theranostics
https://read.qxmd.com/read/38308035/can-conventional-magnetic-resonance-imaging-at-presentation-predict-chemoresistance-in-osteosarcoma
#10
JOURNAL ARTICLE
Thanat Kanthawang, Wanat Wudhikulprapan, Phichayut Phinyo, Jongkolnee Settakorn, Dumnoensun Pruksakorn, Thomas M Link, Nuttaya Pattamapaspong
OBJECTIVES: Histological tumour necrosis is the current indicator for the response of osteosarcoma after neoadjuvant chemotherapy. Chemoresistant tumours require close monitoring and adjustment of treatment. Characteristics of tumours on baseline MRI may be able to predict response to chemotherapy. The aim is to identify which baseline MRI findings can help predict chemoresistant osteosarcoma. METHODS: Baseline MRI before giving neoadjuvant chemotherapy of 95 patients during 2008-2021 was reviewed by 2 musculoskeletal radiologists...
February 2, 2024: British Journal of Radiology
https://read.qxmd.com/read/38166700/imaging-diagnosis-and-differential-diagnosis-of-extraskeletal-osteosarcoma
#11
JOURNAL ARTICLE
Xiao-Chun Wang, Ling Zhang, Jiong-Bin Lin, Xiao-Yao Huang, Jing-Hong Liang, Jian-Ping Zhong, Ji-Dong Peng, Jun-Yuan Zhong
OBJECTIVE: The aim of this study was to investigate the clinical, imaging and pathological features of extraskeletal osteosarcoma (EOS) and to improve the understanding of this disease and other similar lesions. METHODS: The data for 11 patients with pathologically confirmed extraosseous osteosarcoma, including tumour site and size and imaging and clinical manifestations, were analysed retrospectively. RESULTS: Six patients were male (60%), and 5 were female (40%); patient age ranged from 23 to 76 years (average age 47...
January 2, 2024: BMC Cancer
https://read.qxmd.com/read/38154327/self-supervised-tumor-segmentation-and-prognosis-prediction-in-osteosarcoma-using-multiparametric-mri-and-clinical-characteristics
#12
JOURNAL ARTICLE
Zhixun Zhou, Peng Xie, Zhehao Dai, Jia Wu
BACKGROUND AND OBJECTIVE: Osteosarcoma has a high mortality among malignant bone tumors. MRI-based tumor segmentation and prognosis prediction are helpful to assist doctors in detecting osteosarcoma, evaluating the patient's status, and improving patient survival. Current intelligent diagnostic approaches focus on segmentation with single-parameter MRI, which ignores the nature of MRI resulting in poor performance, and lacks the connection with prognosis prediction. Besides, osteosarcoma is a rare disease, and their few labeled data may lead to model overfitting...
December 12, 2023: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38151381/fusion-radiomics-based-prediction-of-response-to-neoadjuvant-chemotherapy-for-osteosarcoma
#13
JOURNAL ARTICLE
Fei Zheng, Ping Yin, Kewei Liang, Yujian Wang, Wenhan Hao, Qi Hao, Nan Hong
RATIONALE AND OBJECTIVES: Neoadjuvant chemotherapy (NAC) is the most crucial prognostic factor for osteosarcoma (OS), it significantly prolongs progression-free survival and improves the quality of life. This study aims to develop a deep learning radiomics (DLR) model to accurately predict the response to NAC in patients diagnosed with OS using preoperative MR images. METHODS: We reviewed axial T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted (T1CE) of 106 patients pathologically confirmed as OS...
December 26, 2023: Academic Radiology
https://read.qxmd.com/read/38108831/therapeutic-efficacy-of-an-alpha-particle-emitter-labeled-anti-gd2-humanized-antibody-against-osteosarcoma-a-proof-of-concept-study
#14
JOURNAL ARTICLE
Ioanna Liatsou, Yingli Fu, Zhi Li, Mahmud Hasan, Xin Guo, Jing Yu, Joseph Piccolo, Allison Cartee, Hao Wang, Yong Du, Jeffrey Bryan, Kathleen Gabrielson, Dara L Kraitchman, George Sgouros
PURPOSE: Current treatments for osteosarcoma (OS) have a poor prognosis, particularly for patients with metastasis and recurrence, underscoring an urgent need for new targeted therapies to improve survival. Targeted alpha-particle therapy selectively delivers cytotoxic payloads to tumors with radiolabeled molecules that recognize tumor-associated antigens. We have recently demonstrated the potential of an FDA approved, humanized anti-GD2 antibody, hu3F8, as a targeted delivery vector for radiopharmaceutical imaging of OS...
December 18, 2023: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38062130/the-il-17-il-17ra-axis-is-required-to-promote-osteosarcoma-progression-in-mice
#15
JOURNAL ARTICLE
Naoto Yoshimura, Ryusho Kariya, Masaki Shimada, Makoto Tateyama, Hideto Matsunaga, Yuto Shibata, Shuntaro Tanimura, Kosei Takata, Takahiro Arima, Junki Kawakami, Kazuya Maeda, Yuko Fukuma, Masaru Uragami, Katsumasa Ideo, Kazuki Sugimoto, Ryuji Yonemitsu, Kozo Matsushita, Satoshi Hisanaga, Masaki Yugami, Yusuke Uehara, Tetsuro Masuda, Takayuki Nakamura, Takuya Tokunaga, Tatsuki Karasugi, Takanao Sueyoshi, Hiro Sato, Yoichiro Iwakura, Kimi Araki, Eisuke Kobayashi, Seiji Okada, Takeshi Miyamoto
Osteosarcoma is rare but is the most common bone tumor. Diagnostic tools such as magnetic resonance imaging development of chemotherapeutic agents have increased the survival rate in osteosarcoma patients, although 5-year survival has plateaued at 70%. Thus, development of new treatment approaches is needed. Here, we report that IL-17, a proinflammatory cytokine, increases osteosarcoma mortality in a mouse model with AX osteosarcoma cells. AX cell transplantation into wild-type mice resulted in 100% mortality due to ectopic ossification and multi-organ metastasis...
December 7, 2023: Scientific Reports
https://read.qxmd.com/read/38044175/what-role-does-pet-mri-play-in-musculoskeletal-disorders
#16
REVIEW
Tugce Telli, Mélanie Desaulniers, Thomas Pyka, Federico Caobelli, Sophia Forstmann, Lale Umutlu, Wolfgang P Fendler, Axel Rominger, Ken Herrmann, Robert Seifert
Musculoskeletal disorders of nononcological origin are one of the most frequent reasons for consultation. Patients suffering from musculoskeletal disorders also consult more than once for the same reason. This results in multiple clinical follow-ups after several radiological and serum examinations, the main ones including X-rays targeting the painful anatomical region and inflammatory serum parameters. As part of their work up, patients suffering from musculoskeletal disorders often require multisequence, multi-parameter MRI...
December 2, 2023: Seminars in Nuclear Medicine
https://read.qxmd.com/read/37871450/hybrid-cnn-transformer-network-for-interactive-learning-of-challenging-musculoskeletal-images
#17
JOURNAL ARTICLE
Lei Bi, Ulrich Buehner, Xiaohang Fu, Tom Williamson, Peter Choong, Jinman Kim
BACKGROUND AND OBJECTIVES: Segmentation of regions of interest (ROIs) such as tumors and bones plays an essential role in the analysis of musculoskeletal (MSK) images. Segmentation results can help with orthopaedic surgeons in surgical outcomes assessment and patient's gait cycle simulation. Deep learning-based automatic segmentation methods, particularly those using fully convolutional networks (FCNs), are considered as the state-of-the-art. However, in scenarios where the training data is insufficient to account for all the variations in ROIs, these methods struggle to segment the challenging ROIs that with less common image characteristics...
October 19, 2023: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/37812494/novel-clinically-translatable-iron-oxide-nanoparticle-for-monitoring-anti-cd47-cancer-immunotherapy
#18
JOURNAL ARTICLE
Raheleh Roudi, Laura Pisani, Fabrizio Pisani, Louise Kiru, Heike E Daldrup-Link
OBJECTIVES: A novel clinically translatable iron oxide nanoparticle (IOP) is currently being tested in phase 2 clinical trials as a magnetic resonance imaging (MRI) contrast agent for hepatocellular carcinoma diagnosis. The purpose of our study is to evaluate if this IOP can detect activation of tumor-associated macrophages (TAMs) due to CD47 mAb-targeted immunotherapy in 2 mouse models of osteosarcoma. MATERIALS AND METHODS: The toxicity, biodistribution, and pharmacokinetics of IOP were evaluated in 77 female and 77 male rats...
October 9, 2023: Investigative Radiology
https://read.qxmd.com/read/37799747/importance-of-3-dimensional-imaging-in-the-early-diagnosis-of-chondroblastic-osteosarcoma
#19
Laura Althea Cuschieri, Rebecca Schembri-Higgans, Nicholas Bezzina, Alexandra Betts, Arthur Rodriguez Gonzalez Cortes
The aim of this report is to present a case of chondroblastic osteosarcoma located in the right maxillary premolar region of a 17-year-old female patient. The initial clinical presentation and 2-dimensional (2D) radiographic methods proved inadequate for a definitive diagnosis. However, a cone-beam computed tomography scan revealed a hyperdense, heterogeneous lesion in the right maxillary premolar region, exhibiting a characteristic "sun-ray" appearance. To assess soft tissue involvement, a medical computed tomography scan was subsequently conducted...
September 2023: Imaging Science in Dentistry
https://read.qxmd.com/read/37789921/3d-print-model-for-surgical-planning-in-a-case-of-recurrent-osteoblastic-osteosarcoma-of-the-left-maxilla-a-case-report
#20
Pedro Zapata-Julían, Daly Avendano, Hector Marcelino Diaz-Peréz, Carmelo Sofia, Maria Adele Marino, Servando Cardona-Huerta
Osteosarcoma (OS) of the head and neck is a rare and aggressive disease characterized by the formation of osteoid by malignant osteoblasts. The mandible or maxilla are the most common sites of presentation. Radiologically, these tumors show considerable, destructive growth with periosteal reaction, which can suggest the diagnosis of OS. 3D printing, as an emerging technology, can play a role in orthopedic oncology by providing patient-specific 3D printed models to improve surgical planning and facilitate patient understanding...
December 2023: Radiology Case Reports
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