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https://www.readbyqxmd.com/read/30006927/gata3-as-a-master-regulator-and-therapeutic-target-in-ovarian-high-grade-serous-carcinoma-stem-cells
#1
Hsiang-Ju Chen, Rui-Lan Huang, Phui-Ly Liew, Po-Hsuan Su, Lin-Yu Chen, Yu-Chun Weng, Cheng-Chang Chang, Yu-Chi Wang, Michael Wing-Yan Chan, Hung-Cheng Lai
Ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy. Prevailing evidences suggest that drug resistance and recurrence of ovarian HGSC are caused by the presence of cancer stem cells. Therefore, targeting cancer stems is appealing, however, all attempts to date, have failed. To circumvent this limit, we analyzed differential transcriptomes at early differentiation of ovarian HGSC stem cells and identified the developmental transcription factor GATA3 as highly expressed in stem, compared to progenitor cells...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30004845/a-systems-biology-approach-to-understanding-the-pathophysiology-of-high-grade-serous-ovarian-cancer-focus-on-iron-and-fatty-acid-metabolism
#2
Anna Konstorum, Miranda L Lynch, Suzy V Torti, Frank M Torti, Reinhard C Laubenbacher
Ovarian cancer (OVC) is the most lethal of the gynecological malignancies, with diagnosis often occurring during advanced stages of the disease. Moreover, a majority of cases become refractory to chemotherapeutic approaches. Therefore, it is important to improve our understanding of the molecular dependencies underlying the disease to identify novel diagnostic and precision therapeutics for OVC. Cancer cells are known to sequester iron, which can potentiate cancer progression through mechanisms that have not yet been completely elucidated...
July 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/30002703/could-first-and-second-trimester-biochemical-markers-for-down-syndrome-have-a-role-in-predicting-intrahepatic-cholestasis-of-pregnancy
#3
Ahter Tanay Tayyar, Ahmet Tayyar, Tolga Atakul, Cigdem Abide Yayla, Cetin Kilicci, Ahmet Eser, Resul Karakus, Dilsat Herkiloglu, Cevat Rifat Cundubey, Mehmet Tayyar
Introduction: The aim of this study is to compare first- and second-trimester Down syndrome biochemical screening markers in intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies. Material and methods: This observational case-control study was conducted at Health Sciences University Zeynep Kamil Maternity and Children's Health Training and Research Hospital and the Department of Obstetrics and Gynecology at Erciyes University Medical Faculty during 2016-2017...
June 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/30002577/the-role-of-gnrh-analogues-in-improving-outcome-in-women-undergoing-superovulation-and-intrauterine-insemination-after-surgical-correction-of-mild-endometriosis-a-randomized-controlled-trial
#4
Piyush Bansal, Kavita Khoiwal, Neena Malhotra, Vatsla Dadhwal, Aparna Sharma, Dipika Deka
Objective: Treatment with laparoscopic surgery, gonadotropin-releasing hormone analog (GnRHa) therapy, superovulation (SO), and intrauterine insemination (IUI) have individual benefits in improving fertility outcomes in women with endometriosis. The aim of the study was to evaluate the role of GnRHa in improving outcome in women undergoing SO and IUI after surgical correction of mild endometriosis. Materials and Methods: This was a randomized controlled trial conducted in the Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India, over a period of 2 years and 6 months...
June 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/30001659/the-association-of-parental-methylenetetrahydrofolate-reductase-polymorphisms-mthfr-677c-t-and-1298a-c-and-fetal-loss-a-case-control-study-in-south-australia
#5
Britt J P Kos, Shalem Leemaqz, Catherine D McCormack, Prabha H Andraweera, Denise L Furness, Claire T Roberts, Gustaaf A Dekker
OBJECTIVE: To determine the association between parental MTHFR 677C>T ( RS1801133 ) and 1298A>C ( RS1801131 ) and fetal loss (FL). DESIGN: Case-control study. SETTING: Department of Obstetrics & Gynecology, Lyell McEwin Hospital (LMH) and the women's and Children's Hospital (WCH) in Adelaide, Australia. PATIENTS: A total of 222 couples with FL and 988 couples with uncomplicated pregnancies. MEASUREMENTS: The main outcomes were FL and hyperhomocysteinemia (HHcy)...
July 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/30001265/preoperative-omental-metastasis-related-maximum-standardized-fluorine-18-fluorodeoxyglucose-uptake-value-can-predict-chemosensitivity-and-recurrence-in-advanced-high-grade-serous-ovarian-cancer-patients
#6
Yuyun Sun, Shuai Liu, Zheng Feng, Jingyi Cheng, Linjun Lu, Mingwei Wang, Huiyu Yuan, Junyan Xu, Yingjian Zhang
OBJECTIVE: The aim of this study was to explore the clinical and prognostic implication of preoperative fluorine-18-fluorodeoxyglucose uptake value of omental metastasis-related in advanced high-grade serous ovarian cancer patients (HGSC). PATIENTS AND METHODS: We retrospectively investigated HGSC patients with omental metastasis (International Federation of Gynecology and Obstetrics stage IIIB-IV) who underwent PET/CT before primary surgery in our hospital between January 2010 and January 2016...
August 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30001237/uterine-pecomas-a-morphologic-immunohistochemical-and-molecular-analysis-of-32-tumors
#7
Jennifer A Bennett, Ana C Braga, Andre Pinto, Koen Van de Vijver, Kristine Cornejo, Anna Pesci, Lei Zhang, Vicente Morales-Oyarvide, Takako Kiyokawa, Gian Franco Zannoni, Joseph Carlson, Tomas Slavik, Carmen Tornos, Cristina R Antonescu, Esther Oliva
Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms that may show overlapping morphology and immunohistochemistry with uterine smooth muscle tumors. In this study, we evaluated the morphologic, immunohistochemical, and molecular features of 32 PEComas, including 11 with aggressive behavior. Two distinct morphologies were observed: classic (n=30) and those with a lymphangioleiomyomatosis appearance (n=2). In the former, patients ranged from 32 to 77 (mean: 51) years and 13% had tuberous sclerosis...
July 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29999104/-objective-structured-clinical-evaluation-to-assess-clinical-skills-of-international-medical-graduates
#8
Claudia Morales, Natalia Álvarez, Paula Candia, Felipe Celedón, Lital Meyer, Katherine Daniel, Nebenka Lombardic, Ernesto Guiraldes
BACKGROUND: Our institution adopted the Objective Structured Clinical Evaluation (OSCE) format to assess clinical skills of International Medical Graduates (IMGs) aiming to practice in Chile. The OSCE has clear advantages over oral exams due to its objective and structured nature. AIM: To report our experience with OSCE. MATERIAL AND METHODS: A team consisting of clinical specialists and medical educators with expertise in clinical simulation organized this OSCE cycle...
March 2018: Revista Médica de Chile
https://www.readbyqxmd.com/read/29998407/underdiagnosis-of-hereditary-breast-and-ovarian-cancer-in-medicare-patients-genetic-testing-criteria-miss-the-mark
#9
Shan Yang, Jennifer E Axilbund, Erin O'Leary, Scott T Michalski, Robbie Evans, Stephen E Lincoln, Edward D Esplin, Robert L Nussbaum
BACKGROUND: An estimated 5-10% of breast and ovarian cancers are due to hereditary causes such as hereditary breast and ovarian cancer (HBOC) syndrome. Medicare, the third-party payer that covers 44 million patients in the United States, has implemented a set of clinical criteria to determine coverage for the testing of the BRCA1 and BRCA2 genes. These criteria, developed to identify carriers of BRCA1/2 variants, have not been evaluated in the panel testing era. This study investigated a series of Medicare patients undergoing genetic testing for HBOC to determine the efficacy of genetic testing criteria in identifying patients with hereditary risk...
July 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29998390/outcomes-of-laparoscopic-management-of-multicompartmental-pelvic-organ-prolapse
#10
J C Martín Del Olmo, M Toledano, M L Martín Esteban, M A Montenegro, J R Gómez, P Concejo, M Rodríguez de Castro, F Del Rio
BACKGROUND: Pelvic organ prolapse (POP) is an increasing medical problem with complex diagnostics and controversial surgical management. It causes a series of dysfunctions in the gynecological, urinary, and anorectal organs. Numerous procedures have been proposed to treat these conditions, but in recent years, ventral mesh rectocolposacropexy (VMRCS) has emerged as the procedure of choice for the surgical treatment of POP, especially by a laparoscopic approach. This surgical technique limits the risk of autonomic nerve damage, and the colpopexy allows the correction of concomitant prolapse of the middle compartment...
July 11, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29998352/three-dimensional-versus-two-dimensional-laparoscopic-right-colectomy-a-systematic-review-and-meta-analysis
#11
Nereo Vettoretto, Luisa Reggiani, Roberto Cirocchi, Brandon Michael Henry, Piero Covarelli, Vito D'Andrea, Georgi Popivanov, Justus Randolph
BACKGROUND: Three-dimensional (3D) vision technology has recently been validated for the improvement of surgical skills in a simulated setting. Clinical studies on specific operations have been published in the field of general, urologic, and gynecologic laparoscopic surgery. We hypothesized that 3D vision laparoscopic right colectomy has better intra and short-term postoperative outcomes than two-dimensional (2D) vision. AIM: The outcomes of this review and meta-analysis were to compare the 3D vision and the 2D vision laparoscopic right colectomy...
July 11, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29998182/resilience-hope-and-flourishing-are-inversely-associated-with-burnout-among-members-of-the-society-for-gynecologic-oncology
#12
Monica Hagan Vetter, Matthew K Vetter, Jeffrey Fowler
Purpose: In this study we sought to: 1) determine rates of burnout and other associated indices of psychosocial distress such as alcohol and substance abuse, 2) establish the baseline performance of gynecologic oncologists on several positive psychology metrics, 3) determine if increased hope, resilience, and flourishing are associated with decreased burnout. Methods: A survey of members of the Society of Gynecologic Oncology (SGO) was conducted in spring of 2017...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29997900/patient-physician-and-caregiver-perspectives-on-ovarian-cancer-treatment-decision-making-lessons-from-a-qualitative-pilot-study
#13
Rachel Pozzar, Laura-Mae Baldwin, Barbara A Goff, Donna L Berry
Background: Ovarian cancer is the deadliest gynecologic malignancy and the fifth leading cause of cancer death among women living in the USA. Treatment for ovarian cancer that follows the guidelines published by the National Comprehensive Cancer Network is associated with a 33% decrease in disease-specific mortality, yet fewer than 40% of women with ovarian cancer receive guideline-adherent treatment. Little is known about the process by which women with ovarian cancer, their unpaid caregivers, and physicians make decisions about ovarian cancer treatment...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29997897/delayed-cord-clamping-during-elective-cesarean-deliveries-results-of-a-pilot-safety-trial
#14
Caroline J Chantry, Aubrey Blanton, Véronique Taché, Laurel Finta, Daniel Tancredi
Background: Delayed cord clamping (DCC) results in decreased iron deficiency in infancy. The American College of Obstetrics and Gynecology has called for research on the optimal time to clamp the cord during cesarean deliveries (CD). Our objective was to conduct a pilot trial examining the safety of delayed cord clamping (DCC) for maternal-infant dyads during elective cesarean delivery (CD). Methods: We enrolled 39 dyads [23 at 90 s, 16 at 120 s; (DCC Pilot)] between 10/2013 and 9/2014...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29997465/microbiological-analysis-of-urine-cultures-in-women-after-pelvic-reconstructive-surgery
#15
Melissa L Dawson, Meagan S Cramer, Dana R Thompson, Babak Vakili
Background/Aims: The rate of urinary tract infection (UTI) after pelvic reconstructive surgery ranges from 9 to 48% and the most common uropathogen is Escherichia coli ( E. coli ). The aim of the study is to identify the predominant uro-pathogen from urine cultures in women undergoing pelvic reconstructive surgery. Methods: A retrospective review was conducted on women who underwent pelvic reconstructive surgery at a tertiary care center from July 2013 to June 2015...
June 2018: Current Urology
https://www.readbyqxmd.com/read/29997439/a-prospective-study-on-neoadjuvant-chemoradiotherapy-plus-anti-egfr-monoclonal-antibody-followed-by-surgery-for-locally-advanced-cervical-cancer
#16
Heming Lu, Yuying Wu, Xu Liu, Hailan Jiang, Qiang Pang, Luxing Peng, Jinjian Cheng, Shan Deng, Junzhao Gu, Renfeng Zhao, Xiaoxia Hu, Changyi Chen, Jinming Yu
Background: To investigate the efficacy and safety of neoadjuvant chemoradiotherapy plus anti-epidermal growth factor receptor monoclonal antibody followed by surgery for locally advanced cervical cancer (LACC). Patients and methods: Patients with histologically proven LACC were enrolled into this prospective study. All patients received intensity-modulated radiation therapy with conventional fractionation. Weekly cisplatin or nedaplatin was administered concurrently with intensity-modulated radiation therapy...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29997359/description-of-genetic-variants-in-brca-genes-in-mexican-patients-with-ovarian-cancer-a-first-step-towards-implementing-personalized-medicine
#17
Jesus Rolando Delgado-Balderas, Maria Lourdes Garza-Rodriguez, Gabriela Sofia Gomez-Macias, Alvaro Barboza-Quintana, Oralia Barboza-Quintana, Ricardo M Cerda-Flores, Ivett Miranda-Maldonado, Hugo Mauricio Vazquez-Garcia, Lezmes Dionicio Valdez-Chapa, Mauro Antonio-Macedo, Michael Dean, Hugo A Barrera-Saldaña
Gynecologic cancers are among the leading causes of death worldwide, ovarian cancer being the one with the highest mortality rate. Olaparib is a targeted therapy used in patients presenting mutations in BRCA1 and BRCA2 genes. The aim of this study was to describe BRCA1 and BRCA2 gene variants in Mexican patients with ovarian cancer. Sequencing of BRCA1 and BRCA2 genes from tumors of 50 Mexican patients with ovarian cancer was made in a retrospective, non-randomized, and exploratory study. We found genetic variants in 48 of 50 cases...
July 11, 2018: Genes
https://www.readbyqxmd.com/read/29997078/screening-and-management-of-hiv-infection-in-pregnant-women-in-dakar
#18
C A T Cissé, M A Inzale, N F Wade, M M Niang, D Diallo, N Ndiaye Seye
OBJECTIVES: To assess the feasibility and results of the implementation of systematic HIV screening of pregnant women and antiretroviral (ARV) treatment for those found to be HIV-positive and their newborns at the IHS Gynecology-Obstetrics Department in Dakar, Senegal. PATIENTS AND METHODS: This cross-sectional prospective study took place in 2014-1016 and examined the results of screening pregnant women for HIV during their prenatal consultations and treating those found to be HIV-positive and their infants with ARV...
May 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29996253/-an-investigation-of-reproductive-health-in-female-workers-engaged-in-administrative-management
#19
Y L Ling, L Y Mei, T T Wei, L L Zhang, L Lu, W L Yu
Objective: To investigate the reproductive health status of female workers engaged in administrative management, and to provide a reference for protecting the reproductive health of female workers. Methods: From April to November, 2016, a cross-sectional survey was performed for 2717 female workers aged 18-60 years and engaged in administrative management from 13 cities and provinces in China, and a questionnaire was used to investigate their general information, occupational hazards in workplace, and reproductive health status, and the reproductive health status of female workers was analyzed...
April 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29995811/wilms-tumor-1-wt1-as-a-prognosis-factor-in-gynecological-cancers-a-meta-analysis
#20
Jingjing Lu, Yang Gu, Qing Li, Huanxin Zhong, Xiaoxue Wang, Zhenxia Zheng, Wenfeng Hu, Lanling Wen
The oncogenic role of Wilms' tumor 1 (WT1) which is regarded as a promising target antigen for cancer immunotherapy has been demonstrated in many types of cancer, but the relationship between expression of WT1 and the prognosis value in gynecological cancer reminds unclear.We performed a meta-analysis with thirteen published studies including 2205 patients searched from PubMed, EMBASE, Web of Science, and Google Scholar, whose results are expressed by overall survival (OS) or disease-specific survival (DSS) or disease-free survival or relapse/recurrence-free survival (RFS) or progression-free survival (PFS) in patients with gynecological cancer...
July 2018: Medicine (Baltimore)
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