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https://www.readbyqxmd.com/read/28944048/dysmenorrhea-and-related-disorders
#1
REVIEW
Mariagiulia Bernardi, Lucia Lazzeri, Federica Perelli, Fernando M Reis, Felice Petraglia
Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. The secondary forms of dysmenorrhea are associated with endometriosis and adenomyosis and may represent the key symptom...
2017: F1000Research
https://www.readbyqxmd.com/read/28943941/impact-of-positive-zeb1-expression-in-patients-with-epithelial-ovarian-carcinoma-as-an-oncologic-outcome-predicting-indicator
#2
Jun Sakata, Hiroaki Kajiyama, Shiro Suzuki, Fumi Utsumi, Kaoru Niimi, Ryuichiro Sekiya, Kiyosumi Shibata, Takeshi Senga, Fumitaka Kikkawa
Several previous studies have revealed that the expression of zinc finger E-box binding homeobox 1 (ZEB1) in solid malignancies has an important significance on the clinical outcome of patients. However, the association between ZEB1 expression and survival in patients with epithelial ovarian carcinoma (EOC) remains unclear. The objective of the present study was to examine the extent of ZEB1 expression in EOC using immunohistochemical staining and investigate its association with patient outcome. A total of 40 patients with EOC initially treated with cytoreductive surgery and systematic chemotherapy were enrolled...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943192/preoperative-factors-that-predict-the-need-to-morcellate-in-total-laparoscopic-hysterectomy
#3
Morgan Wolfe, Scott Biest, Nhial Tutlam, Candice Woolfolk, Brooke Winner
STUDY OBJECTIVE: To determine which preoperative factors best predict the need for uterine morcellation at the time of total laparoscopic hysterectomy and to identify cut-offs that can help guide clinical decision-making. DESIGN: Data were collected from a prospective quality assurance database and reviewed retrospectively. Preoperative factors assessed included uterine volume, cross-sectional area, length, size of largest leiomyoma, and bimanual exam. Receiver-operator curves (ROC) were used to establish cut-offs that maximized sensitivity and specificity for each factor...
September 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28943191/laparoscopic-myomectomy-with-temporary-bilateral-uterine-artery-occlusion-compared-with-traditional-surgery-for-uterine-fibroids-blood-loss-and-recurrence
#4
Limei Ji, Lanying Jin, Min Hu
STUDY OBJECTIVE: To compare the surgical technique of temporary bilateral uterine artery blockage with titanium clips in laparoscopic myomectomy with traditional surgery for uterine fibroids to determine efficacy, ability to control bleeding, and recurrence. DESIGN: Randomized, controlled, prospective study (Canadian Task Force classification I). SETTING: Obstetrics and gynecology department in Jinhua Municipal Central Hospital. PATIENTS: Women with symptomatic uterine myoma...
September 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28942697/ovarian-masses-in-pediatric-patients-a-multicenter-study-of-98-surgical-cases-in-tunisia
#5
I Abid, M Zouari, M Jallouli, S Sahli, A Bouden, R Ben Abdallah, F Trabelsi, A Jabloun, A Charieg, C Mrad, M Marzouki, S Mosbahi, A Ezzi, R Mootamri, M Hamzaoui, N Kaabar, S Jlidi, A Nouri, R Mhiri
Ovarian masses requiring surgical intervention are uncommon in the pediatric population. Our aim is to report results of a multicentric Tunisian study concerning the clinical practice and the management of pediatric ovarian masses and to identify the factors that are associated with ovarian preservation. Between January 2000 and December 2015, 98 pediatric patients (<14 years) were surgically treated for ovarian masses at the five pediatric surgery departments in Tunisia. Ninety-eight patients were included in this study...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942106/familiarity-with-long-acting-reversible-contraceptives-among-obstetrics-and-gynecology-family-medicine-and-pediatrics-residents-results-of-a-2015-national-survey-and-implications-for-contraceptive-provision-for-adolescents
#6
Susan A Davis, Nikolay P Braykov, Eva Lathrop, Lisa B Haddad
OBJECTIVE: To assess familiarity with long-acting reversible contraceptives (LARC) among current Obstetrics and Gynecology (OB/GYN), Family Medicine (FM), and Pediatrics senior residents in the United States. METHODS: We selected 156 OB/GYN, FM, and Pediatrics residency programs using the AMA Freida database. Senior residents completed a survey addressing any training they had received on LARC, and rated their comfort level counseling about and inserting LARC. Residents rated their likelihood of recommending LARC to an adolescent, nulliparous patient, and indicated whether they would like additional training on LARC...
September 20, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28941657/effects-of-a-complex-rehabilitation-program-on-edema-status-physical-function-and-quality-of-life-in-lower-limb-lymphedema-after-gynecological-cancer-surgery
#7
Jung Hwa Do, Kyoung Hyo Choi, Jun Su Ahn, Jae Yong Jeon
OBJECTIVE: The purpose of this study was to investigate the effects of a complex rehabilitation (CR) program and complex decongestive therapy (CDT) on edema status, physical function, and quality of life in patients with unilateral lower-limb lymphedema after gynecologic cancer surgery. METHODS: In this randomized pilot study, 40 patients with secondary unilateral lymphedema, after gynecologic surgery for cervical, endometrial, or ovarian cancer, that had been diagnosed based on clinical assessment and 10% volume differences between the legs were randomly assigned to the CDT (n=20) and CDT combined with CR (CRCDT; n=20) groups...
September 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28941656/factors-influencing-fertility-sparing-treatment-for-gynecologic-malignancies-a-survey-of-society-of-gynecologic-oncology-members
#8
Jaimin S Shah, Rosa Guerra, Diane C Bodurka, Charlotte C Sun, Gary B Chisholm, Terri L Woodard
OBJECTIVES: This study aims to examine practice patterns of gynecologic oncologists (GO) regarding fertility-sparing treatments (FST) for gynecology malignancies and explores attitudes toward collaboration with reproductive endocrinologists (RE). METHODS: An anonymous 23-question survey was sent to 1087 GO with a 14.0% completion rate. Descriptive statistics, Fisher's exact test, and Chi-square tests were used for data analysis. RESULTS: The majority of GOs offer FST for gynecologic malignancies...
September 21, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28941461/nigericin-inhibits-epithelial-ovarian-cancer-metastasis-by-suppressing-the-cell-cycle-and-epithelial-mesenchymal-transition
#9
Wen Wang, Yan Zhao, Shujuan Yao, Xiujuan Cui, Wenying Pan, Wenqian Huang, Jiangang Gao, Taotao Dong, Shiqian Zhang
Epithelial ovarian cancer (EOC) has the highest mortality among various types of gynecological malignancies. Most patients die of metastasis and recurrence due to cisplatin resistance. Thus, it is urgent to develop novel therapies to cure this disease. CCK-8 assay showed that nigericin exhibited strong cytotoxicity on A2780 and SKOV3 cell lines. Flow cytometry indicated that nigericin could induce cell cycle arrest at G0/G1 phase and promote cell apoptosis. Boyden chamber assay revealed that nigericin could inhibit migration and invasion in a dose-dependent manner by suppressing epithelial-mesenchymal transition (EMT) in EOC cells...
August 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28941280/optimizing-the-amount-of-simulation-training-used-to-teach-vaginal-delivery-skills-to-medical-students
#10
Joshua F Nitsche, Timberly Butler, Alison Shew, Sha Jin, Brian C Brost
OBJECTIVE: To determine the amount of simulation training required for students to attain minimal competence and mastery of a vaginal delivery. METHODS: An observational study was conducted at a US medical school between May 11, 2015, and May 8, 2016. Using a modified Angoff method, 10 members of the Obstetrics and Gynecology faculty evaluated a vaginal delivery procedural checklist and established cutoff scores for minimal competence and mastery. During a 5-week period, all third-year students received between two and five 45-minute vaginal delivery simulation sessions; performance was assessed at week 6...
September 23, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28940023/cells-of-origin-of-ovarian-cancer-ovarian-surface-epithelium-or-fallopian-tube
#11
REVIEW
Daniel Martin Klotz, Pauline Wimberger
OBJECTIVE: Ovarian cancer is the fifth most common cancer in women and one of the leading causes of death from gynecological malignancies. Despite of its clinical importance, ovarian tumorigenesis is poorly understood and prognosis remains poor. This is particularly true for the most common type of ovarian cancer, high-grade serous ovarian cancer. RESULTS: Two models are considered, whether it arises from the ovarian surface epithelium or from the fallopian tube...
September 23, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28938975/factors-predicting-catheter-related-bladder-discomfort-in-surgical-patients
#12
Namhee Lim, Haesang Yoon
PURPOSE: The study was conducted to identify the factors predicting catheter-related bladder discomfort (CRBD) in the postanesthesia care unit, to assess the level of CRBD and urinary catheter-related pain for the first 24 hours postoperatively, and to compare UCRP with the postoperative pain in the surgical site. BACKGROUND: About 20% of hospitalized patients receive an indwelling urinary catheter, and more than half of these patients complain of CRBD or urinary catheter-related pain...
October 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28938748/random-start-ovarian-stimulation-for-fertility-preservation-appears-unlikely-to-delay-initiation-of-neoadjuvant-chemotherapy-for-breast-cancer
#13
Joseph M Letourneau, Nikita Sinha, Kaitlyn Wald, Eve Harris, Molly Quinn, Tal Imbar, Evelyn Mok-Lin, A Jo Chien, Mitchell Rosen
STUDY QUESTION: Is random start ovarian stimulation associated with delays in initiation of neoadjuvant chemotherapy for breast cancer? SUMMARY ANSWER: Among women who complete fertility preservation (FP) consultation, random start ovarian stimulation is unlikely to delay time to initiation of neoadjuvant chemotherapy start. WHAT IS KNOWN ALREADY: Neoadjuvant chemotherapy is now a widely accepted treatment modality for operable breast cancer and random start ovarian stimulation is an increasingly-utilized modality for FP...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938482/microrna-221-3p-regulates-angiopoietin-like-8-angptl8-expression-in-adipocytes
#14
Raghavendra Mysore, Francisco J Ortega, Jèssica Latorre, Maria Ahonen, Hanna Savolainen-Peltonen, Pamela Fischer-Posovszky, Martin Wabitsch, Vesa M Olkkonen, José M Fernández-Real, P A Nidhina Haridas
Context: Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design: We addressed the correlation between ANGPTL8 mRNA with hallmark insulin-regulated and lipogenic genes in human adipose tissue. The regulation of ANGPTL8 expression in adipocytes was studied after inflammatory challenge, and the role of microRNA-221-3p therein was investigated. Results: ANGPTL8 gene expression in subcutaneous (SAT) and visceral (VAT) adipose tissue was highly correlated with SLC2A4/GLUT4 and ADIPOQ/Adiponectin...
August 30, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938062/news-from-the-editors-roberto-romero-editor-of-ultrasound-in-obstetrics-and-gynecology-from-2003-to-2017-steps-down
#15
Stuart Campbell
No abstract text is available yet for this article.
September 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28937771/urinary-metabolic-phenotyping-of-women-with-lower-urinary-tract-symptoms
#16
Rhiannon Bray, Stefano Cacciatore, Beatriz Jimenez, Rufus Cartwright, Alex Digesu, Ruwan Fernando, Elaine Holmes, Jeremy Kirk Nicholson, Phillip R Bennett, David A MacIntyre, Vik Khullar
Lower urinary tract symptoms (LUTS), including urinary incontinence, urgency and nocturia, affect approximately half of women worldwide. Current diagnostic methods for LUTS are invasive and costly, while available treatments are limited by side effects leading to poor patient compliance. In this study, we aimed to identify urine metabolic signatures associated with LUTS using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy. A total of 214 urine samples were collected from women attending tertiary urogynaecology clinics (cases; n=176) and healthy control women attending general gynecology clinics (n=36)...
September 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28937561/venous-thromboembolism-an-unrecognized-crisis-in-gynecologic-oncology
#17
Edward M Lichten
No abstract text is available yet for this article.
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937544/trends-of-gynecological-cancers-in-turkey-toward-europe-or-asia
#18
Murat Gultekin, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Selin Dundar, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
OBJECTIVE: The aim of this study was to evaluate nationwide gynecological cancer trends in Turkey. METHODS: National cancer registry data (2009-2013) of Turkish Ministry of Health were evaluated. Ovarian, cervical, endometrial, vulvar, vaginal, and tubal cancers are evaluated with respect to age of diagnosis, incidence rates within years, stage, histological distributions, and mortality rates. Data were collected from active cancer registry centers, which increased from 23% in 2009 to 47...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28937515/laparoscopic-major-vascular-injury-simulation-using-a-synthetic-compared-with-porcine-model
#19
Magdy P Milad, Farah A Alvi, Michael T Breen, Cynthia Brincat, Peter J Frederick, Christina Lewicky-Gaupp, Mark Lewis, Bryan Rone, Kimberly Swan, Karin Wollschlaeger
BACKGROUND: Major vascular injury training may improve clinical skills and reduce patient morbidity during gynecologic laparoscopy; thus, reliable models for simulation should be identified. METHOD: Two laparoscopic major vascular injury simulations using synthetic or live porcine models were constructed. The primary surgeon was given the opportunity to complete both simulations. After obtaining peritoneal access, the surgeon quickly encountered a major vascular injury...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937514/surgical-skills-feedback-and-mytipreport-is-there-construct-validity
#20
AnnaMarie Connolly, Anita Blanchard, Alice Goepfert, Nicole Donnellan, Elizabeth Buys, Richard Uribe, Kimberly Kenton
OBJECTIVE: To initiate construct validity testing of myTIPreport for procedural skill assessment in a prospective multicenter evaluation study. METHODS: Teachers and learners from a convenience-based site selection of obstetrics and gynecology (OBGYN) and female pelvic medicine and reconstructive surgery (FPMRS) training programs performed procedural assessments in myTIPreport. The specifically defined 5-point Dreyfus rating scale describing ability levels from novice to expert was used...
October 2017: Obstetrics and Gynecology
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