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https://www.readbyqxmd.com/read/29772552/pet-ct-in-the-diagnosis-and-prognosis-of-osteosarcoma
#1
Xiaojuan Zhang, Zhe Guan
Osteosarcoma is an aggressive malignancy that usually occurs in children and young adults, and long-term survival is only about 20% in patients with metastasis or recurrent disease. Traditional non-invasive techniques, such as positron-emission tomography (PET) scanning, magnetic resonance imaging (MRI) or computed tomography (CT) scanning, may not identify single lesions in the early stage or accurately detect small lesions. A novel technique, positron emission tomography/computed tomography (PET/CT), which is widely used in clinical practice, shows more accuracy, sensitivity, and specificity in the diagnosis of osteosarcoma...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#2
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29643686/primary-fibroblastic-osteosarcoma-of-the-lumbar-vertebra-on-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#3
Jae Pil Hwang
A 37-year-old man who presented with one year history of lower back and right buttock pain was investigated with contrast enhanced computed tomography (CT), magnetic resonance imaging (MRI), and fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography which revealed a diagnosis of primary fibroblastic osteosarcoma of the lumbar vertebra. This case highlights the importance of PET/CT imaging.
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29552435/plasmacytoma-of-the-skull-base-a-rare-tumor
#4
Abhilasha Siyag, Tej P Soni, Anil K Gupta, Lalit M Sharma, Naresh Jakhotia, Shantanu Sharma
Plasmacytoma of the skull-base is a rare entity. Differential diagnosis includes chordoma, osteosarcoma, carcinoma nasopharynx, meningioma, metastatic carcinoma, lymphoma, and multiple myeloma. Accurate and precise diagnosis is extremely important for plasmacytoma of the skull-base as its treatment and prognosis is different from other skull-base lesions. A 41-year-old man presented with concerns of headache, diplopia, and left eye strabismus. A magnetic resonance image (MRI) of his brain showed a large expansile mass measuring 51 mm involving the clivus and central skull-base...
January 15, 2018: Curēus
https://www.readbyqxmd.com/read/29529641/mri-identification-of-the-osseous-extent-of-pediatric-bone-sarcomas
#5
Matthew J Thompson, John C Shapton, Stephanie E Punt, Christopher N Johnson, Ernest U Conrad
BACKGROUND: The quantitative accuracy of MRI in predicting the intraosseous extent of primary sarcoma of bone has not been definitively confirmed, although MRI is widely accepted as an accurate tool to plan limb salvage resections. Because inaccuracies in MRI determination of tumor extent could affect the ability of a tumor surgeon to achieve negative margins and avoid local recurrence, we thought it important to assess the accuracy of MR-determined tumor extent to the actual extent observed pathologically from resected specimens in pediatric patients treated for primary sarcomas of bone...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29504754/noninvasive-multimodal-imaging-of-osteosarcoma-and-lymph-nodes-using-a-99m-tc-labeled-biomineralization-nanoprobe
#6
Zhiming Xu, Yangyun Wang, Jianshan Han, Qingqing Xu, Jiawei Ren, Jiaying Xu, Yong Wang, Zhifang Chai
The accurate imaging of the lymph nodes represents a critical indicator for tumor staging and surgical planning (e.g., osteosarcoma). Clinically, nodal tracing using a radio-nanocolloid is often limited by the inaccessibility of real-time images and inadequate anatomical information. Herein, we present a 99m Tc-labeled biomineralization nanoprobe for the advanced detection of osteosarcoma and lymph nodes with multimodal imaging. Through the exploitation of the complementary strengths of MRI/SPECT/NIR fluorescence, the fabricated nanoprobe exhibited suitable stability and biocompatibility characteristics and was shown to be able to be located in osteosarcoma...
April 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29502131/clinical-radiological-and-pathological-features-of-extraskeletal-osteosarcoma
#7
Lauren A Roller, Ivan Chebib, Miriam A Bredella, Connie Y Chang
OBJECTIVE: To evaluate clinical and radiological features of pathology-proven extraskeletal osteosarcomas. METHODS: This retrospective study was IRB-approved and HIPAA-compliant. Our pathology database was queried for cases of extraskeletal osteosarcoma. Tumor location, size, imaging appearance, presence of metastases, and clinical outcome were documented. RESULTS: Nineteen patients met inclusion criteria (age 59 ± 15 (range 28-85) years; 15 male, 4 female)...
March 3, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29471560/knochensarkome
#8
Jendrik Hardes, Georg Gosheger, Timo Budny
Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29429892/osteosarcoma-subtypes-magnetic-resonance-and-quantitative-diffusion-weighted-imaging-criteria
#9
Rania Zeitoun, Ahmed M Shokry, Sahar Ahmed Khaleel, Shaimaa M Mogahed
INTRODUCTION: Osteosarcoma (OS) is a primary bone malignancy, characterized by spindle cells producing osteoid. The objective of this study is to describe the magnetic resonance imaging (MRI) features of different OS subtypes, record their attenuation diffusion coefficient (ADC) values and to point to the relation of their pathologic base and their corresponding ADC value. PATIENTS AND METHODS: We performed a retrospective observational lesion-based analysis for 31 pathologically proven osteosarcoma subtypes: osteoblastic (n = 9), fibroblastic (n = 8), chondroblastic (n = 6), para-osteal (n = 3), periosteal (n = 1), telangiectatic (n = 2), small cell (n = 1) and extra-skeletal (n = 1)...
March 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29390546/primary-osteosarcoma-of-frontal-bone-a-case-report-and-review-of-literature
#10
REVIEW
Guangyong Wu, Qi Liang, Yu Liu
RATIONALE: Primary osteosarcomas of the skull and skull base are rare, comprising <2% of all skull tumors. Primary osteosarcomas of the skull are aggressive neoplasms composed of spindle cells producing osteoid which have poor outcome. PATIENT CONCERNS: A 33-year-old woman was admitted to our hospital with a major complaint of a growing mass on her left frontal region of the skull for 10 months. Prior to the accurate diagnosis, the mass on her skull was considered to be eosinophilic granuloma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388036/anaplastic-plasmacytoma-a-rare-tumor-presenting-as-a-pathological-fracture-in-a-younger-adult
#11
Robert W Morris, Varsha Kumar, Ali G Saad
Solitary plasmacytoma is the rarest type of plasma cell neoplasm, and the anaplastic form is even more uncommon. Plasmacytoma most commonly originates in bone and predominantly affects older patients. We describe the case of a 35-year-old woman with solitary osseous anaplastic plasmacytoma that presented initially with a pathological fracture following minor trauma. The patient was immunocompetent and had no predisposing conditions for a plasma cell tumor. Left lower extremity radiographs revealed an oblique fracture of the distal femur, and CT imaging indicated a primary osseous lesion at the fracture site...
January 31, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29210434/nano-confinement-driven-enhanced-magnetic-relaxivity-of-spions-for-targeted-tumor-bioimaging
#12
Tuyen Duong Thanh Nguyen, Arunkumar Pitchaimani, Colin Ferrel, Ravindra Thakkar, Santosh Aryal
Superparamagnetic iron oxide nanoparticles (SPIONs) are highly biocompatible and have a versatile synthetic technique based on coprecipitation, reduction-precipitation, and hydrothermal methods, where Fe3+ and Fe2+ react in aqueous solutions; both these ions are present in our body and have clear metabolic pathways; therefore, they have attracted extensive research interest and development in the field of diagnostic imaging and therapy. However, most SPION-based clinical diagnostic contrast agents are discontinued due to severe pain, low transverse magnetic relaxivity range of 80-180 mM-1 s-1 , shorter circulation half-life, and lack of disease specificity...
December 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29196822/osteogenic-melanoma-report-of-a-case-mimicking-osteosarcoma-and-review-of-the-literature
#13
Deepika Savant, Shachar Kenan, Samuel Kenan, Leonard Kahn
A 32-year-old male presented with a right thumb lesion of 11-month duration. A clinical diagnosis of pyogenic granuloma was entertained but the lesion failed to respond to conservative therapy and eventually necessitated amputation of his thumb. MRI of the right thumb showed an ill-defined, heterogeneously enhancing, infiltrating mass within the dorsal soft tissues abutting the distal phalanx and measuring 4.2 × 2.4 × 0.7 cm. Histologically, the tumor was composed of a high-grade osteosarcoma with a chondrosarcomatous component localized within the underlying bone and a more superficial spindle cell component in the overlying soft tissue...
December 1, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29113210/analysis-of-imaging-characteristics-of-primary-malignant-bone-tumors-in-children
#14
Yingwei Sun, Xueyong Liu, Shinong Pan, Chunbo Deng, Xiaohan Li, Qiyong Guo
The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had osteosarcoma, with radiography and computed tomography (CT) showing osteolytic bone destruction or/and osteoblastic bone sclerosis, an aggressive periosteal reaction, a soft-tissue mass and cancerous bone...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113159/treatment-of-osteosarcoma-around-the-knee-in-skeletally-immature-patients
#15
Weitao Yao, Qiqing Cai, Jiaqiang Wang, Songtao Gao
Limb sparing surgery in growing young patients with malignant tumors is difficult as invasion of the physis by the tumor or surgical resection through the metaphysis may cause significant limb discrepancy following surgery. At present, hinged tumor prosthesis or biological reconstructions are the main methods following tumor resection in these patients. The aim of the present study was to assess different procedures for the treatment of osteosarcoma around knee joints in immature patients. A retrospective study of 56 patients (<15 years old, open physis) who had been treated for osteosarcoma around the knee joint between January 2007 and December 2015 was performed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29104842/concurrent-multiple-myeloma-and-metastatic-osteosarcoma-a-case-report-and-literature-review
#16
Ashley Ramirez, Vincent Grekoski, Michael Valente, Fiona Tissavirasingham, Alessandra Fahey, Nicole Guevara, John W Stelzer, M Joe Ma, Jeremy Burt
Multiple myeloma (MM) and osteosarcoma (OS) are two common bone malignancies, however, the simultaneous occurrence of both primary bone tumors in the same patient has not been reported in the United States to date. We present a unique case in which both malignancies present concurrently in a 72-year-old man. Results of spinal magnetic resonance imaging (MRI), radiographic skeletal survey, and hematological workup established the initial diagnosis of MM. Approximately three months later, the patient was admitted with severe right hip pain and shortness of breath and was evaluated with computed tomography (CT) of the right hip, abdomen, pelvis, and chest, revealing an osseous mass with a "sunburst" pattern in the right hip, and several calcified nodules in the lungs...
August 31, 2017: Curēus
https://www.readbyqxmd.com/read/29021951/marrow-signal-mimicking-tumor-on-mri-t1-weighted-imaging-after-neoadjuvant-chemotherapy-in-extremity-osteosarcomas
#17
Zhiping Deng, Yi Ding, Lin Hao, Qing Zhang, Yongbin Su, Xiaohui Niu
PURPOSE: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. METHODS: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study...
March 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28887617/fdg-pet-ct-appearance-of-local-osteosarcoma-recurrences-in-pediatric-patients
#18
Susan E Sharp, Barry L Shulkin, Michael J Gelfand, M Beth McCarville
BACKGROUND: Osteosarcoma is the most common pediatric malignant bone tumor, frequently surgically managed with limb salvage rather than amputation. Local recurrences are seen in up to 9% of osteosarcoma patients, with CT and MRI imaging often limited by metal artifacts. OBJECTIVE: To describe the [F-18]2-fluoro-2-deoxyglucose (FDG) PET/CT appearance of local osteosarcoma recurrences with correlation to findings on other imaging modalities. MATERIALS AND METHODS: A retrospective review of pediatric osteosarcoma patients imaged with FDG PET/CT was performed in patients with pathologically proven local recurrences...
December 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28808701/osteosarcoma-of-the-mandible-a-case-report-with-ct-mri-and-scintigraphy
#19
Mikiko Sue, Takaaki Oda, Yoshihiko Sasaki, Ayako Kameta, Yasuo Okada, Ichiro Ogura
Osteosarcomas are especially rare in the mandible and maxilla, representing 1.6% of all bony malignant tumours. In this article, we described a case of osteosarcoma of the mandible. Computed tomography (CT) image showed a well-circumscribed homogeneous mass, with nonhomogeneous contrast enhancement. T1-weighted magnetic resonance imaging (MR) image showed intermediate signal intensity on, and after administration the lesion showed signal intensity lower than muscle. T2-weighted MR image showed heterogeneous high signal intensity...
2017: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/28781793/activation-of-the-arachidonic-acid-metabolic-pathway-and-induction-of-sleep-disturbance-by-sacral-osteoblastoma-a-case-report
#20
Mitsunori Ozaki, Kazuya Nishioka, Akihiko Kimura, Toshikazu Kondo, Naoyuki Nakao
Osteoblastomas are benign bone tumors that produce prostaglandin and promote inflammation. The aim of the present study was to describe the clinical and radiological characteristics of a pediatric osteoblastoma case over an 8-month postoperative follow-up. The case involved an 11-year-old female patient with normal somatic development, presenting with a chief complaint of sleep disturbance. The patient had no spontaneous pain or other readily evident possible causes. Magnetic resonance imaging (MRI) revealed a neoplastic lesion in the sacrum, with peritumoral edema...
August 2017: Molecular and Clinical Oncology
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