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https://www.readbyqxmd.com/read/28593144/schwannoma-of-the-femur-a-rare-case-report
#1
Fahad Al-Lhedan
Schwannoma is a benign tumor derived from Schwann cells that cover myelinated nerve fibers (1). Among primary bone tumors, intraosseous schwannoma accounts for less than 0.2% (2). We are reporting a rare case of an 18-year-old female presented with swelling in the posterior right thigh. The patient was asymptomatic and this was incidentally discovered by her massage therapist. However, the swelling was gradually growing since then. The plain radiograph findings were suggestive of a benign bone tumor. MRI with gadolinium was performed for further evaluation but it demonstrated suspicious features as evidenced by the extra osseous enhancing soft tissue component...
September 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28546707/clinico-pathological-study-of-limb-salvage-surgery-for-osteosarcoma-experience-in-a-rural-cancer-center
#2
Divya Vijayanarasimha, Sangeetha K Nayanar, Syam Vikram, Vijay M Patil, Satheesh Babu, Satheesan B
Although recent multimodality therapeutic protocols have led to improved survival in osteosarcoma (OS), the outcome still remains dismal. Ongoing international multicentric trials on OS aim to randomize patients for optimum management, based on histological response to NACT. The pathologic response to neoadjuvant chemotherapy (NACT) is the most important factor predicting prognosis. In this study of 23 cases of limb salvage surgery post neoadjuvant chemotherapy, mean age was 18.3 years, with male predominance...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28536749/extraskeletal-osteosarcoma-arising-in-myositis-ossificans-a-case-report-and-review-of-the-literature
#3
Deepika Savant, Shachar Kenan, Samuel Kenan, Leonard Kahn
We report a case of a 23-year-old female with pain and fullness in the right popliteal fossa. An MRI scan demonstrated an ossified enhancing soft tissue mass. Evaluation of the resected specimen showed a high-grade extraskeletal osteosarcoma juxtaposed to the three zones of myositis ossificans. At 1-year follow-up the patient is alive and disease free. A review of the literature purporting to document such an association failed to demonstrate a single case in which an osteosarcoma and MO with its zonal architecture co-existed...
August 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28469335/pediatric-osteosarcoma-an-updated-review
#4
REVIEW
Shachi Jain Taran, Rakesh Taran, Nagraj B Malipatil
Osteosarcoma (OS), the most common type of primary malignant bone tumor, is defined by the presence of malignant mesenchymal cells producing osteoid or immature bone. The peak incidence of the most frequent type of OS, i.e., high-grade central OS, occurs in the second decade of life during the adolescent growth spurt. Most patients suffer from the pain and swelling in the involved region and, usually, seek medical attention. Diagnosis is carried out by conventional radiographs, computed tomography, and magnetic resonance image (MRI)...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28374954/multifunctional-gadolinium-doped-mesoporous-tio2-nanobeads-photoluminescence-enhanced-spin-relaxation-and-reactive-oxygen-species-photogeneration-beneficial-for-cancer-diagnosis-and-treatment
#5
Roghayeh Imani, Ralf Dillert, Detlef W Bahnemann, Meysam Pazoki, Tomaž Apih, Veno Kononenko, Neža Repar, Veronika Kralj-Iglič, Gerrit Boschloo, Damjana Drobne, Tomas Edvinsson, Aleš Iglič
Materials with controllable multifunctional abilities for optical imaging (OI) and magnetic resonant imaging (MRI) that also can be used in photodynamic therapy are very interesting for future applications. Mesoporous TiO2 sub-micrometer particles are doped with gadolinium to improve photoluminescence functionality and spin relaxation for MRI, with the added benefit of enhanced generation of reactive oxygen species (ROS). The Gd-doped TiO2 exhibits red emission at 637 nm that is beneficial for OI and significantly improves MRI relaxation times, with a beneficial decrease in spin-lattice and spin-spin relaxation times...
April 4, 2017: Small
https://www.readbyqxmd.com/read/28306496/use-of-magnetic-resonance-imaging-guided-biopsy-of-a-vertebral-body-mass-to-diagnose-osteosarcoma-in-a-rottweiler
#6
Rebecca A Krimins, Jan Fritz, Larry A Gainsburg, Patrick R Gavin, Elizabeth A Ihms, David L Huso, Dara L Kraitchman
CASE DESCRIPTION A 9-year-old spayed female Rottweiler with hind limb ataxia was examined because of anorexia and an acute onset of hind limb paresis. CLINICAL FINDINGS Neurologic evaluation revealed hind limb ataxia and symmetric paraparesis with bilaterally abnormal hind limb postural reactions including hopping, hemiwalking, hemistanding, and delayed proprioception, which were suggestive of a lesion somewhere in the T3-L3 segment of the spinal cord. Thoracolumbar radiography revealed an abnormal radiopacity suggestive of a mass at T11...
April 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28301537/dedifferentiated-chondrosarcoma-radiological-features-prognostic-factors-and-survival-statistics-in-23-patients
#7
Chenglei Liu, Yan Xi, Mei Li, Qiong Jiao, Huizhen Zhang, Qingcheng Yang, Weiwu Yao
BACKGROUND: Dedifferentiated chondrosarcoma is a rare, highly malignant tumor with a poor survival. There are many confusing issues concerning the imaging feature that can facilitate early diagnosis and the factors that might be related to outcomes. METHODS: Twenty-three patients with dedifferentiated chondrosarcoma confirmed by pathology were retrospectively reviewed from 2008 to 2015. The patients' clinical information, images from radiographs (n = 17), CT (n = 19), and MRI (n = 17), histological features, treatment and prognosis were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28243595/cns-metastases-from-bone-and-soft-tissue-sarcomas-in-children-adolescents-and-young-adults-are-they-really-so-rare
#8
Monika Bekiesinska-Figatowska, Agnieszka Duczkowska, Marek Duczkowski, Hanna Bragoszewska, Anna Romaniuk-Doroszewska, Beata Iwanowska, Sylwia Szkudlinska-Pawlak, Jaroslaw Madzik, Katarzyna Bilska, Anna Raciborska
Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. Methods. Patients with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded...
2017: BioMed Research International
https://www.readbyqxmd.com/read/27933253/primary-intracerebral-osteosarcoma-a-rare-case-report-and-review
#9
Song-Ping Chen, Jin-Long Tang, Xiu-Liang Zhu
BACKGROUND: Primary intracranial osteosarcoma is a extremely rare disease entity. We describe a case of primary intracerebral osteosarcoma in an adult brain. CASE DESCRIPTION: A patient who presented with a 1-week history of headaches, and MRI examination was performed. The immunohistochemical diagnosis confirmed primary intracerebral osteosarcoma. The patient was treated with a surgical resection of the tumor. CONCLUSION: Primary osteosarcomas occurring in the brain are extremely rare...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27889090/focal-nodular-and-diffuse-haematopoietic-marrow-hyperplasia-in-patients-with-underlying-malignancies-a-radiological-mimic-of-malignancy-in-need-of-recognition
#10
L T C Chow, A W H Ng, S K C Wong
AIM: To report the authors' experience of focal nodular haematopoietic marrow hyperplasia (FNHMH) and diffuse haematopoietic marrow hyperplasia (DHMH) clinically masquerading as skip, distant, or disseminated metastasis in seven patients with underlying malignant neoplasms. MATERIALS AND METHODS: Five patients with FNHMH and two with DHMH mistaken radiologically as skip and disseminated metastasis, respectively, were compared and contrasted with four patients with osteosarcomas and two with chondrosarcomas harbouring skip metastasis, noting the temporal relationship with their haematological profile...
March 2017: Clinical Radiology
https://www.readbyqxmd.com/read/27823978/clinical-characteristics-and-prognoses-of-six-patients-with-multicentric-giant-cell-tumor-of-the-bone
#11
Chenglei Liu, Yawen Tang, Mei Li, Qiong Jiao, Huizhen Zhang, Qingcheng Yang, Weiwu Yao
Multicentric giant cell tumor of the bone (MGCT) is a rare entity whose radiographic, pathological and biological features remain confusing. We retrospectively reviewed six patients (1 male, 5 female; average age, 22.33 years) treated for confirmed MGCT between 2001 and 2015. The patients' clinical information, images from radiographs (n = 14), CT (n = 13), MRI (n = 8), bone scintigraphy (n = 1) and PET-CT (n = 2), as well as histologic features, treatment and prognosis were analyzed. A total of 17 lesions were detected: 4 around the knee joint, 3 in the greater trochanter and head of the femur, 5 in the small bones of the feet, and 2 in flat bones...
December 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27748868/gadolinium-chloride-elicits-apoptosis-in-human-osteosarcoma-u-2-os-cells-through-extrinsic-signaling-intrinsic-pathway-and-endoplasmic-reticulum-stress
#12
Yuh-Feng Tsai, Ching-Wen Huang, Jo-Hua Chiang, Fuu-Jen Tsai, Yuan-Man Hsu, Chi-Cheng Lu, Chen-Yu Hsiao, Jai-Sing Yang
Gadolinium (Gd) compounds are important as magnetic resonance imaging (MRI) contrast agents, and are potential anticancer agents. However, no report has shown the effect of gadolinium chloride (GdCl3) on osteosarcoma in vitro. The present study investigated the apoptotic mechanism of GdCl3 on human osteosarcoma U-2 OS cells. Our results indicated that GdCl3 significantly reduced cell viability of U-2 OS cells in a concentration-dependent manner. GdCl3 led to apoptotic cell shrinkage and DNA fragmentation in U-2 OS cells as revealed by morphologic changes and TUNEL staining...
December 2016: Oncology Reports
https://www.readbyqxmd.com/read/27627776/-atipic-osteosarcoma-in-the-femoral-shaft-case-report-and-review-of-the-literature
#13
M A Clara-Altamirano, D Y García-Ortega, J L Martínez-Tlahuel, H Martínez-Said, C H S Caro-Sánchez, G C García-Ruíz, C R Mejía-Salazar, M Cuellar-Hubbe
Osteosarcoma is the most frequent primary malignant bone tumor. It is characterized by osteoid production by tumor cells. Its most frequent location is in the metaphyses of long bones, but a purely diaphyseal presentation is reported in 10% of cases. We report the case of a female 25 year-old patient whose symptoms of pain and swelling of the right mid thigh started four months before, without an apparent cause. Femur X-rays showed a tumor in the femoral shaft. The MRI showed extension to soft tissues with no compromise of the neurovascular bundle...
January 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27386494/primary-extraskeletal-pleural-osteosarcoma-a-rare-pleural-identity
#14
Hannah Copeland, Peter B Makdisi, Michael Duncan, Thomas C Wozniak, George Makdisi
A 69-year-old female with a history of a heart transplant 16 years prior, presented with a large left chest mass identified on fluoroscopy in the cardiac catheterization lab. The patient noted a 40 pound weight loss in one year. A chest X-ray (CXR) and chest computed tomography (CT) demonstrated a large complex cystic mass in the left chest. A CT guided aspiration was performed, and the cytology for the cyst fluid was negative for malignancy. The patient continued to have worsening shortness of breath, a repeat chest CT scan and magnetic resonance imaging (MRI) three months later, demonstrated a recurrence of the left pleural mass...
June 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27384722/impacts-of-tumor-location-nature-and-bone-destruction-of-extremity-osteosarcoma-on-selection-of-limb-salvage-operative-procedure
#15
Yu Chen, Xiu-Chun Yu, Song-Feng Xu, Ming Xu, Ruo-Xian Song
OBJECTIVE: To study the impacts of tumor location, nature and extent of bone destruction on selection of operative protocol for extremity osteosarcoma (OS). METHODS: The medical records of 201 patients with extremity OS treated in our institute from December 1999 to June 2014 were retrospectively reviewed. Ninety eligible patients (56 males and 34 females) of average age 20 ± 11 years (range, 4-40 years) were enrolled. Tumor locations were categorized as diaphyseal (4; diaphysis group) or juxta-articular (86); the latter being subclassified as with (51, type III, epiphysis group) or without invasion beyond the epiphyseal line or plate (35, type I and II, metaphysis group) according to MRI images...
May 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/27255551/-osteogenic-tumors-of-bone
#16
B Jobke, M Werner
BACKGROUND: Osteogenic tumors include malignant and benign tumors that produce tumor osteoid and/or bone tissue. Osteosarcoma is the most common malignant bone tumor, especially in children and young adults. OBJECTIVES: The entities with their characteristic morphological features are described to enable the reader to come to a diagnosis and differential diagnosis on the basis of patient age, history and predominant location of the tumor. METHODS: For this review we selectively used mainly large published patient cohorts...
June 2016: Der Radiologe
https://www.readbyqxmd.com/read/27229874/percent-slope-analysis-of-dynamic-magnetic-resonance-imaging-for-assessment-of-chemotherapy-response-of-osteosarcoma-or-ewing-sarcoma-systematic-review-and-meta-analysis
#17
Tadahiko Kubo, Taisuke Furuta, Muhammad P Johan, Nobuo Adachi, Mitsuo Ochi
OBJECTIVE: The objective of this systematic review is to provide an up-to-date and unprecedented summary of percent slope analysis of dynamic magnetic resonance imaging (MRI) for the preoperative evaluation of the chemotherapy response of osteosarcoma or Ewing sarcoma. MATERIALS AND METHOD: Studies evaluating dynamic MRI for the preoperative evaluation of the chemotherapy response of osteosarcoma or Ewing sarcoma were systematically searched for in MEDLINE, EMBASE, and Web of Science...
September 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27052403/spinal-chordomas-dedifferentiated-to-osteosarcoma-a-report-of-two-cases-and-a-literature-review
#18
Satoshi Kato, Alessandro Gasbarrini, Riccardo Ghermandi, Marco Gambarotti, Stefano Bandiera
PURPOSE: Chordoma is a rare, locally aggressive neoplasm of the bone that arises from embryonic notochordal remnants. In less than 5 % of cases, chordomas contain a highly malignant sarcomatous component. Because of the rarity of such tumors, little is known about their clinical features and optimal treatment options. Herein, we report two chordoma cases with malignant sarcomatoid areas, consistent with high-grade osteosarcoma in the primary spine lesions, and discuss the presentation and characteristics of this disease...
May 2016: European Spine Journal
https://www.readbyqxmd.com/read/26998347/solitary-synovial-chondromatosis-arising-in-the-gluteus-maximus-bursa-computed-tomography-and-magnetic-resonance-imaging-findings
#19
Kaoru Sumida, Noriko Kobayashi, Atsushi Nambu, Masao Tago, Isao Shibuya, Masashi Kawamoto
Chondral tumors in soft tissue are referred to as soft-tissue chondromas or extraskeletal chondromas, or as synovial chondromatosis if they arise in synovial tissue. We report the case of a 29-year-old man with synovial chondromatosis, also called synovial osteochondromatosis, which appeared in a solitary and extra-articular form. On magnetic resonance imaging (MRI) and computed tomography, the central portion of the tumor showed similar characteristics to bone marrow, despite the absence of any connection to adjacent bone...
March 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/26997197/3d-printed-guiding-templates-for-improved-osteosarcoma-resection
#20
Limin Ma, Ye Zhou, Ye Zhu, Zefeng Lin, Yingjun Wang, Yu Zhang, Hong Xia, Chuanbin Mao
Osteosarcoma resection is challenging due to the variable location of tumors and their proximity with surrounding tissues. It also carries a high risk of postoperative complications. To overcome the challenge in precise osteosarcoma resection, computer-aided design (CAD) was used to design patient-specific guiding templates for osteosarcoma resection on the basis of the computer tomography (CT) scan and magnetic resonance imaging (MRI) of the osteosarcoma of human patients. Then 3D printing technique was used to fabricate the guiding templates...
March 21, 2016: Scientific Reports
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