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https://www.readbyqxmd.com/read/28991104/international-consensus-statement-on-the-clinical-and-therapeutic-management-of-leber-s-hereditary-optic-neuropathy
#1
Valerio Carelli, Michele Carbonelli, Irenaeus F de Coo, Aki Kawasaki, Thomas Klopstock, Wolf A Lagrèze, Chiara La Morgia, Nancy J Newman, Christophe Orssaud, Jan Willem R Pott, Alfredo A Sadun, Judith van Everdingen, Catherine Vignal-Clermont, Marcela Votruba, Patrick Yu-Wai-Man, Piero Barboni
Leber hereditary optic neuropathy (LHON) is currently estimated as the most frequent mitochondrial disease (1 in 27,000-45,000). Its molecular pathogenesis and natural history is now fairly well understood. LHON also is the first mitochondrial disease for which a treatment has been approved (idebenone-Raxone, Santhera Pharmaceuticals) by the European Medicine Agency, under exceptional circumstances because of the rarity and severity of the disease. However, what remains unclear includes the optimal target population, timing, dose, and frequency of administration of idebenone in LHON due to lack of accepted definitions, criteria, and general guidelines for the clinical management of LHON...
October 3, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28989845/comparison-perioperative-factors-during-minimally-invasive-pre-psoas-lateral-interbody-fusion-of-the-lumbar-spine-using-either-navigation-or-conventional-fluoroscopy
#2
Yue-Hui Zhang, Ian White, Eric Potts, Jean-Pierre Mobasser, Dean Chou
STUDY DESIGN: Retrospective clinical study. OBJECTIVES: The aim of this study was to compare intraoperative conditions and clinical results of patients undergoing pre-psoas oblique lateral interbody fusion (OLIF) using navigation or conventional fluoroscopy (C-ARM) techniques. METHODS: Forty-two patients (22 patients by navigation and 20 by fluoroscopy) underwent the OLIF procedure at 2 medical centers, and records were reviewed. Clinical data was collected and compared between the 2 groups...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28985080/wettability-of-reentrant-surfaces-a-global-energy-approach
#3
Marion Lucia Silvestrini, Carolina Brito
In this work we consider two possible wetting states for a droplet when placed on a substrate: the Fakir configuration of a Cassie-Baxter (CB) state with a droplet residing on top of roughness grooves and the one characterized by the homogeneous wetting of the surface, referred as the Wenzel (W) state. We extend a theoretical model based on the global interfacial energies for both states CB and W to study the wetting behavior of simple and double reentrant surfaces. Due to the minimization of the energies associated to each wetting state, we predict the thermodynamic wetting state of the droplet for a given surface texture and obtain its contact angle θ<u>c</u>...
October 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28983248/the-effects-of-sea0400-on-ca-2-transient-amplitude-and-proarrhythmia-depend-on-the-na-ca-2-exchanger-expression-level-in-murine-models
#4
Nils Bögeholz, Jan S Schulte, Sven Kaese, B Klemens Bauer, Paul Pauls, Dirk G Dechering, Gerrit Frommeyer, Joshua I Goldhaber, Uwe Kirchhefer, Lars Eckardt, Christian Pott, Frank U Müller
Background/Objective: The cardiac Na(+)/Ca(2+) exchanger (NCX) has been identified as a promising target to counter arrhythmia in previous studies investigating the benefit of NCX inhibition. However, the consequences of NCX inhibition have not been investigated in the setting of altered NCX expression and function, which is essential, since major cardiac diseases (heart failure/atrial fibrillation) exhibit NCX upregulation. Thus, we here investigated the effects of the NCX inhibitor SEA0400 on the Ca(2+) transient amplitude and on proarrhythmia in homozygous NCX overexpressor (OE) and heterozygous NCX knockout (hetKO) mice compared to corresponding wild-types (WTOE/WThetKO)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28980059/avoiding-implementation-failure-in-catchment-landscapes-a-case-study-in-governance-of-the-great-barrier-reef
#5
Allan P Dale, Karen Vella, Margaret Gooch, Ruth Potts, Robert L Pressey, Jon Brodie, Rachel Eberhard
Water quality outcomes affecting Australia's Great Barrier Reef (GBR) are governed by multi-level and multi-party decision-making that influences forested and agricultural landscapes. With international concern about the GBR's declining ecological health, this paper identifies and focuses on implementation failure (primarily at catchment scale) as a systemic risk within the overall GBR governance system. There has been limited integrated analysis of the full suite of governance subdomains that often envelop defined policies, programs and delivery activities that influence water quality in the GBR...
October 4, 2017: Environmental Management
https://www.readbyqxmd.com/read/28978744/a-dynamically-diluted-alignment-model-reveals-the-impact-of-cell-turnover-on-the-plasticity-of-tissue-polarity-patterns
#6
Karl B Hoffmann, Anja Voss-Böhme, Jochen C Rink, Lutz Brusch
The polarization of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern reorganization in response to an opposing instructive cue, which we here consider using the example of experimentally inducible body axis inversions in planarian flatworms. We define a dynamically diluted alignment model linking three processes: entrainment of cell polarity by a global signal, local cell-cell coupling aligning polarity among neighbours, and cell turnover replacing polarized cells by initially unpolarized cells...
October 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28962664/a-new-concept-for-implant-borne-dental-rehabilitation-how-to-overcome-the-biological-weak-spot-of-conventional-dental-implants
#7
Nils-Claudius Gellrich, Björn Rahlf, Rüdiger Zimmerer, Philipp-Cornelius Pott, Majeed Rana
BACKGROUND: Every endosseous dental implant is dependent on an adequate amount and quality of peri-implant hard and soft tissues and their fully functional interaction. The dental implant could fail in cases of insufficient bone and soft tissues or due to a violation of the soft to hard tissues to implant shoulder interface with arising of a secondary bone loss. METHOD: To overcome this biological weak-spot, we designed a new implant that allows for multi vector endosseous anchorage around the individual underlying bone, which has to be scanned by computed tomography (CT) or Cone beam CT (CBCT) technique to allow for planning the implant...
September 29, 2017: Head & Face Medicine
https://www.readbyqxmd.com/read/28956509/multiple-causal-pathways-in-attention-deficit-hyperactivity-disorder-do-emerging-executive-and-motivational-deviations-precede-symptom-development
#8
Ursula Pauli-Pott, Susan Schloß, Monika Heinzel-Gutenbrunner, Katja Becker
The multiple causal pathways model on the etiology of attention-deficit/hyperactivity disorder (ADHD) is well established. However, developmental implications of the model are not yet sufficiently analyzed. The model implies that critical neural and neuropsychological deviations from normative development precede secondarily developing ADHD symptoms. Cognitive, "cool" inhibitory control (CIC) and reward-related, "hot" functions (RRF) are regarded as neuropsychological basic deficits that indicate independent causal pathways...
September 28, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28954761/a-case-of-pott-s-puffy-tumour-from-primary-dental-infection
#9
Thomas Geyton, Arthur Henderson, James Morris, Steve McDonald
No abstract text is available yet for this article.
September 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28945631/crossing-the-language-barrier-a-role-playing-activity
#10
Ann Marie Doyle-Moss, Sekboppa Sor, Sherry D Krupka, Angela Potts
No abstract text is available yet for this article.
September 22, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28942055/delivering-social-work-services-in-collaboration-with-the-legal-representation-for-individual-clients-an-effective-ethical-and-economical-approach-to-supporting-families-in-child-abuse-and-neglect-legal-proceedings
#11
Robbin Pott
This article discusses the need to improve the quality of helping relationships between families and social workers in the child protection system and the growing body of evidence that teams of social workers and lawyers are effective at improving outcomes in child protection legal proceedings. The author presents an alternative structure of delivering social work services within the child protection systems once a court gets involved with a family, proposing that social workers should focus on individual clients in collaboration with their legal representation, rather than the traditional model of a governmental agency social worker serving the family as a unit as it also determines placement of the children...
September 20, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28938167/a-method-for-measuring-manual-position-control
#12
Cory Adam Potts, Alexander A Brown, Stanislaw Solnik, David A Rosenbaum
There is no generally accepted method for measuring manual position control. We developed a method for doing so. We asked university students to hold a handle that had one rotational degree of freedom. The angular position of the handle depended on the degree of pronation-supination of the forearm. The subjects' task was to hold the handle as steadily as possible to keep a needle positioned in a pie-shaped target zone on a computer screen. If the needle remained in the zone for 0.5s, the gain of the feedback loop increased; otherwise the gain decreased or remained at the starting value of 1...
October 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28938055/photosynthetic-phenological-variation-may-promote-coexistence-among-co-dominant-tree-species-in-a-madrean-sky-island-mixed-conifer-forest
#13
D L Potts, R L Minor, Z Braun, G A Barron-Gafford
Across much of western North America, forests are predicted to experience a transition from snow- to rain-dominated precipitation regimes due to anthropogenic climate warming. Madrean sky island mixed conifer forests receive a large portion of their precipitation from summertime convective storms and may serve as a lens into the future for snow-dominated forests after prolonged warming. To better understand the linkage between physiological traits, climate variation, and the structure and function of mixed conifer forests, we measured leaf photosynthetic (A) responses to controlled variation in internal CO2 concentration (Ci) to quantify interspecific phenological variation in A/Ci-derived ecophysiological traits among ponderosa pine (Pinus ponderosa Lawson and C...
September 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28935234/fractal-rules-in-brain-networks-signatures-of-self-organization
#14
Soibam Shyamchand Singh, Dineshchandra Haobijam, Md Zubbair Malik, Romana Ishrat, R K Brojen Singh
We study brain network data of three species, namely, C. elegans, cat and macaque monkey within the framework of network theory and Potts Hamiltonian model, and explore rich fractal nature in it, which could be an important signature of self-organization, and a simple rule to be obeyed in complex patterns of brain networks. Further, this fractal behaviors in topological parameters of brain networks at various network levels could be an indicator of systems level organization in complicated brain functionality...
September 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28929016/age-growth-mortality-and-reproductive-seasonality-of-jolthead-porgy-calamus-bajonado-from-florida-waters
#15
Michael L Burton, Jennifer C Potts, Jordan Page, Ariel Poholek
Ages of jolthead porgy (Calamus bajonado Schneider 1801) (n = 635) from Florida commercial and recreational fisheries from 2008-2016 were determined using sectioned sagittal otoliths. We determined, using edge-type analysis, that opaque zones were annular, forming March-June (peaking in April). Jolthead porgy ranged from 1-13 years, and the largest fish measured 680 mm TL (total length, mm). Body size relationships for jolthead porgy were TL = 1.09FL + 20.44 (n = 622, r(2) = 0.99), FL = 0.90 TL -14...
2017: PeerJ
https://www.readbyqxmd.com/read/28920926/particulate-allergens-potentiate-allergic-asthma-in-mice-through-sustained-ige-mediated-mast-cell-activation
#16
Cong Jin, Christopher P Shelburne, Guojie Li, Erin N Potts, Kristina J Riebe, Gregory D Sempowski, W Michael Foster, Soman N Abraham
No abstract text is available yet for this article.
October 2, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28918062/detection-of-no-model-input-output-pairs-in-closed-loop-systems
#17
Alain Segundo Potts, Christiam Segundo Morales Alvarado, Claudio Garcia
The detection of no-model input-output (IO) pairs is important because it can speed up the multivariable system identification process, since all the pairs with null transfer functions are previously discarded and it can also improve the identified model quality, thus improving the performance of model based controllers. In the available literature, the methods focus just on the open-loop case, since in this case there is not the effect of the controller forcing the main diagonal in the transfer matrix to one and all the other terms to zero...
September 13, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28914174/-dis-entangling-barad-materialisms-and-ethics
#18
Gregory Hollin, Isla Forsyth, Eva Giraud, Tracey Potts
In the wake of the widespread uptake of and debate surrounding the work of Karen Barad, this article revisits her core conceptual contributions. We offer descriptions, elaborations, problematizations and provocations for those intrigued by or invested in this body of work. We examine Barad's use of quantum physics, which underpins her conception of the material world. We discuss the political strengths of this position but also note tensions associated with applying quantum physics to phenomena at macro-scales...
September 1, 2017: Social Studies of Science
https://www.readbyqxmd.com/read/28910602/hair-cortisol-concentration-in-preschoolers-with-attention-deficit-hyperactivity-symptoms-roles-of-gender-and-family-adversity
#19
Ursula Pauli-Pott, Susan Schloß, Isabelle Ruhl, Nadine Skoluda, Urs M Nater, Katja Becker
OBJECTIVE: Previous studies on the association between hypothalamic-pituitary-adrenal axis (HPAA) activity and ADHD yielded inconsistent findings, particularly in younger children. This might be due to the heterogeneity of the disorder, making moderator effects of variables probable, which circumscribe more homogenous subgroups. There have been indications of moderator effects on this association by gender of child and exposure to family adversity. Moreover, difficulties in capturing long-term basal HPAA activity in younger children might have contributed to the inconsistencies...
September 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28906019/response-letter-to-optimising-physiology-for-adolescents-with-dysautonomia
#20
K Armstrong, A M De Souza, P Sneddon, J E Potts, V E Claydon, S Sanatani
We would like to thank Dr Thaxter Nesbeth (1) for her interest and insightful comments on our paper entitled, "Exercise and the multidisciplinary holistic approach to adolescent dysautonomia"(2). We agree that recurrent orthostatic intolerance is often best managed through lifestyle modification rather than pharmacologic intervention (at least as an initial step), and as such in the present study we evaluated the impact of our exercise programme incorporated in addition to our standard clinical multidisciplinary management approach...
September 14, 2017: Acta Paediatrica
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