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https://www.readbyqxmd.com/read/28818959/accessing-off-field-brains-in-sport-an-applied-research-model-to-develop-practice
#1
EDITORIAL
Ben Jones, Kevin Till, Stacey Emmonds, Sharief Hendricks, Peter Mackreth, Joshua Darrall-Jones, Gregory Roe, Sir Ian McGeechan, Richard Mayhew, Richard Hunwicks, Neill Potts, Michael Clarkson, Andy Rock
No abstract text is available yet for this article.
August 17, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28818564/validity-of-a-smartphone-protractor-to-measure-sagittal-parameters-in-adult-spinal-deformity
#2
William Aaron Kunkle, Michael Madden, Shannon Potts, Jeremy Fogelson, Stuart Hershman
BACKGROUND CONTEXT: Smartphones have become an integral tool in the daily life of healthcare professionals (Franko 2011). Their ease of use and wide availability often make smartphones the first tool surgeons use to perform measurements. This technique has been validated for certain orthopaedic pathologies (Shaw 2012, Quek 2014, Milanese 2014, Milani 2014), but never to assess sagittal parameters in adult spinal deformity. This study was designed to assess the validity, reproducibility, precision and efficiency of using a smartphone protractor application to measure sagittal parameters commonly measured in adult spinal deformity assessment and surgical planning...
August 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28809994/the-static-physician-s-global-assessment-of-genitalia-a-clinical-outcome-measure-for-the-severity-of-genital-psoriasis
#3
Joseph F Merola, Alison Potts Bleakman, Alice B Gottlieb, Alan Menter, April N Naegeli, Robert Bissonnette, Lyn Guenther, John Sullivan, Kim Meeuwis, Kyoungah See, Kristina Callis Duffin
<p>Introduction: Genital psoriasis is a common but frequently overlooked manifestation of psoriasis with a considerable impact on patients' quality of life. Currently no validated clinical trial outcome measures exist to assess genital psoriasis severity that meet regulatory agency requirements.</p> <p>Methods: This study describes the development of the static Physician's Global Assessment of Genitalia (sPGA-G) scale, a clinical outcome measure for the assessment of genital psoriasis severity that accounts for the erythematous clinical presentation of genital psoriasis...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28805524/response-to-the-editorial-by-dr-geraghty
#4
Peter D White, Trudie Chalder, Michael Sharpe, Brian J Angus, Hannah L Baber, Jessica Bavinton, Mary Burgess, Lucy V Clark, Diane L Cox, Julia C DeCesare, Kimberley A Goldsmith, Anthony L Johnson, Paul McCrone, Gabrielle Murphy, Maurice Murphy, Hazel O'Dowd, Laura Potts, Rebacca Walwyn, David Wilks
This article is written in response to the linked editorial by Dr Geraghty about the adaptive Pacing, graded Activity and Cognitive behaviour therapy; a randomised Evaluation (PACE) trial, which we led, implemented and published. The PACE trial compared four treatments for people diagnosed with chronic fatigue syndrome. All participants in the trial received specialist medical care. The trial found that adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was as safe as, and more effective than, adding adaptive pacing therapy or specialist medical care alone...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28799399/nucleation-barrier-reconstruction-via-the-seeding-method-in-a-lattice-model-with-competing-nucleation-pathways
#5
Yuri Lifanov, Bart Vorselaars, David Quigley
We study a three-species analogue of the Potts lattice gas model of nucleation from solution in a regime where partially disordered solute is a viable thermodynamic phase. Using a multicanonical sampling protocol, we compute phase diagrams for the system, from which we determine a parameter regime where the partially disordered phase is metastable almost everywhere in the temperature-fugacity plane. The resulting model shows non-trivial nucleation and growth behaviour, which we examine via multidimensional free energy calculations...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28791648/assessment-of-specificity-of-an-adenovirus-targeted-to-her3-4
#6
Sheena H MacLeod, Kyle G Potts, Shyambabu Chaurasiya, Mary M Hitt
Gene therapy with viral vectors, such as adenovirus (Ad), targeted to the human epidermal growth factor receptors 3 and 4 (HER3/4) are potentially useful for cancer therapy. Testing the expression of a reporter gene from these viruses in target cells is essential to determine functionality of the targeted virus. A competition assay with a relevant ligand (heregulin, HRG) can provide convincing evidence that blocking binding to the HER3/4 receptor results in decreased reporter gene expression. Labeling individual viruses with a fluorescent molecule allows examination of the targeted virus in specific steps in the infection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28761700/a-novel-treadmill-protocol-for-exercise-testing-in-children-the-british-columbia-children-s-hospital-protocol
#7
D Kathryn Duff, Astrid M De Souza, Derek G Human, James E Potts, Kevin C Harris
BACKGROUND: Exercise testing in children is widely recommended for a number of clinical and prescriptive reasons. Many institutions continue to use the Bruce protocol for treadmill testing; however, with its incremental changes in speed and grade, it has challenges for practical application in children. We have developed a novel institutional protocol (British Columbia Children's Hospital (BCCH)), which may have better utility in paediatric populations. AIM: To determine if our institutional protocol yields similar peak responses in minute ventilation (VE), oxygen consumption (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), metabolic equivalents (METS) and heart rate (HR) when compared with the traditional Bruce protocol...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28760035/minimally-invasive-versus-open-fusion-for-grade-i-degenerative-lumbar-spondylolisthesis-analysis-of-the-quality-outcomes-database
#8
Praveen V Mummaneni, Erica F Bisson, Panagiotis Kerezoudis, Steven Glassman, Kevin Foley, Jonathan R Slotkin, Eric Potts, Mark Shaffrey, Christopher I Shaffrey, Domagoj Coric, John Knightly, Paul Park, Kai-Ming Fu, Clinton J Devin, Silky Chotai, Andrew K Chan, Michael Virk, Anthony L Asher, Mohamad Bydon
OBJECTIVE Lumbar spondylolisthesis is a degenerative condition that can be surgically treated with either open or minimally invasive decompression and instrumented fusion. Minimally invasive surgery (MIS) approaches may shorten recovery, reduce blood loss, and minimize soft-tissue damage with resultant reduced postoperative pain and disability. METHODS The authors queried the national, multicenter Quality Outcomes Database (QOD) registry for patients undergoing posterior lumbar fusion between July 2014 and December 2015 for Grade I degenerative spondylolisthesis...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28759050/rps26-directs-mrna-specific-translation-by-recognition-of-kozak-sequence-elements
#9
Max B Ferretti, Homa Ghalei, Ethan A Ward, Elizabeth L Potts, Katrin Karbstein
We describe a novel approach to separate two ribosome populations from the same cells and use this method in combination with RNA-seq to identify mRNAs bound to Saccharomyces cerevisiae ribosomes with and without Rps26, a protein linked to the pathogenesis of Diamond-Blackfan anemia (DBA). These analyses reveal that Rps26 contributes to mRNA-specific translation by recognition of the Kozak sequence in well-translated mRNAs and that Rps26-deficient ribosomes preferentially translate mRNA from select stress-response pathways...
July 31, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28758638/influenza-virus-recruits-host-protein-kinase-c-to-control-assembly-and-activity-of-its-replication-machinery
#10
Arindam Mondal, Anthony R Dawson, Gregory K Potts, Elyse C Freiberger, Steven F Baker, Lindsey A Moser, Kristen A Bernard, Joshua J Coon, Andrew Mehle
Influenza virus expresses transcripts early in infection and transitions towards genome replication at later time points. This process requires de novo assembly of the viral replication machinery, large ribonucleoprotein complexes (RNPs) composed of the viral polymerase, genomic RNA and oligomeric nucleoprotein (NP). Despite the central role of RNPs during infection, the factors dictating where and when they assemble are poorly understood. Here we demonstrate that human protein kinase C (PKC) family members regulate RNP assembly...
July 31, 2017: ELife
https://www.readbyqxmd.com/read/28751099/efficacy-and-safety-of-delayed-release-dimethyl-fumarate-for-relapsing-remitting-multiple-sclerosis-in-prior-interferon-users-an-integrated-analysis-of-define-and-confirm
#11
Óscar Fernández, Gavin Giovannoni, Robert J Fox, Ralf Gold, J Theodore Phillips, James Potts, Macaulay Okwuokenye, Jing L Marantz
PURPOSE: In Phase III studies (DEFINE [Determination of the Efficacy and Safety of Oral Fumarate in Relapsing-Remitting MS]/CONFIRM [Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis]), delayed-release dimethyl fumarate (DMF) demonstrated significant efficacy and a favorable benefit-risk profile in patients with relapsing-remitting multiple sclerosis (RRMS). Post hoc analyses of integrated data from DEFINE/CONFIRM were conducted to evaluate the effect of DMF in patients previously treated with interferon (IFN) beta...
July 24, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28748004/-dorsolumbar-cold-abscess-revealing-pott-s-disease
#12
Kouame Jean-Eric Kouassi, Loukou Blaise Yao, Bada Justin Léopold Niaore Sery, Kouamé Innocent M'bra, Koffi Léopold Krah, Grah Franck Lohourou, Michel Kodo
Tuberculous cold abscesses are a rare and unusual form of extrapulmonary tuberculosis. We here report the case of a 27-year old patient with a 5-month history of left dorsolumbar swelling presenting with dorsolumbar cold abscess revealing Pott's disease without neurological complications. Examination of pus sample collected at the time the abscess was incised and drained helped to confirm the diagnosis of cold abscesses of TB origin. The patient underwent 12 months of anti-tuberculosis treatment which lead to a faster recovery; the sequelae was slight gibbosity...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28747450/magnesium-hemostasis-and-outcomes-in-patients-with-intracerebral-hemorrhage
#13
Eric M Liotta, Shyam Prabhakaran, Rajbeer S Sangha, Robin A Bush, Alan E Long, Stephen A Trevick, Matthew B Potts, Babak S Jahromi, Minjee Kim, Edward M Manno, Farzaneh A Sorond, Andrew M Naidech, Matthew B Maas
OBJECTIVE: We tested the hypothesis that admission serum magnesium levels are associated with hematoma volume, hematoma growth, and functional outcomes in patients with intracerebral hemorrhage (ICH). METHODS: Patients presenting with spontaneous ICH were enrolled in an observational cohort study that prospectively collected demographic, clinical, laboratory, radiographic, and outcome data. We performed univariate and adjusted multivariate analyses to assess for associations between serum magnesium levels and initial hematoma volume, final hematoma volume, and in-hospital hematoma growth as radiographic measures of hemostasis, and functional outcome measured by the modified Rankin Scale (mRS) at 3 months...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28731094/assembly-and-dichroism-of-a-four-component-halogen-bonded-metal-organic-cocrystal-salt-solvate-involving-dicyanoaurate-i-acceptors
#14
Jan-Constantin Christopherson, Karlie P Potts, Oleksandr S Bushuyev, Filip Topić, Igor Huskić, Kari Rissanen, Christopher J Barrett, Tomislav Friščić
We describe the use of dicyanoaurate ions as linear ditopic metal-organic acceptors for the halogen bond-driven assembly of a dichroic metal-organic cocrystal based on azobenzene chromophores. Structural analysis by single crystal X-ray diffraction revealed that the material is a four-component solid, consisting of anticipated anionic metal-organic halogen-bonded chains based on dicyanoaurate ions, as well as complex potassium-based cations and discrete molecules of the crown ether 15-crown-5. Importantly, the structural analysis revealed the parallel alignment of the halogen-bonded chains required for dichroic behaviour, confirming that crystal engineering principles developed for the design of halogen-bonded dichroic organic cocrystals are also applicable to metal-based structures...
July 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28720836/calcifying-algae-maintain-settlement-cues-to-larval-abalone-following-algal-exposure-to-extreme-ocean-acidification
#15
Jennifer K O'Leary, James P Barry, Paul W Gabrielson, Laura Rogers-Bennett, Donald C Potts, Stephen R Palumbi, Fiorenza Micheli
Ocean acidification (OA) increasingly threatens marine systems, and is especially harmful to calcifying organisms. One important question is whether OA will alter species interactions. Crustose coralline algae (CCA) provide space and chemical cues for larval settlement. CCA have shown strongly negative responses to OA in previous studies, including disruption of settlement cues to corals. In California, CCA provide cues for seven species of harvested, threatened, and endangered abalone. We exposed four common CCA genera and a crustose calcifying red algae, Peyssonnelia (collectively CCRA) from California to three pCO2 levels ranging from 419-2,013 µatm for four months...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28713383/the-toxicological-mechanisms-of-environmental-soot-black-carbon-and-carbon-black-focus-on-oxidative-stress-and-inflammatory-pathways
#16
REVIEW
Rituraj Niranjan, Ashwani Kumar Thakur
The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their underlying mechanisms of toxicity are still poorly understood. Both are formed after the incomplete combustion of hydrocarbons but differ in their constituents and percent carbon contents. For the first time, "Sir Percival Pott" described soot as a carcinogen, which was subsequently confirmed by many others. The existing data suggest three main types of diseases due to soot and CB exposures: cancer, respiratory diseases, and cardiovascular dysfunctions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28709307/determination-of-the-conformal-field-theory-central-charge-by-the-wang-landau-algorithm
#17
P A Belov, A A Nazarov, A O Sorokin
We present a simple method to estimate the central charge of the conformal field theory corresponding to a critical point of a two-dimensional lattice model from Monte Carlo simulations. The main idea is to use the Wang-Landau flat-histogram algorithm, which allows us to obtain the free energy of a lattice model on a torus as a function of torus radii. The central charge is calculated with good precision from a free-energy scaling at the critical point. We apply the method to the Ising, tricritical Ising (Blume-Capel), Potts, and site-diluted Ising models, and we also discuss an estimation of the conformal weights...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28700972/evaluating-the-use-of-in-situ-turbidity-measurements-to-quantify-fluvial-sediment-and-phosphorus-concentrations-and-fluxes-in-agricultural-streams
#18
Marc Stutter, Julian J C Dawson, Miriam Glendell, Fiona Napier, Jacqueline M Potts, James Sample, Andrew Vinten, Helen Watson
Accurate quantification of suspended sediments (SS) and particulate phosphorus (PP) concentrations and loads is complex due to episodic delivery associated with storms and management activities often missed by infrequent sampling. Surrogate measurements such as turbidity can improve understanding of pollutant behaviour, providing calibrations can be made cost-effectively and with quantified uncertainties. Here, we compared fortnightly and storm intensive water quality sampling with semi-continuous turbidity monitoring calibrated against spot samples as three potential methods for determining SS and PP concentrations and loads in an agricultural catchment over two-years...
July 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28696745/exact-results-for-quenched-bond-randomness-at-criticality
#19
Gesualdo Delfino
We introduce an exact replica method for the study of critical systems with quenched bond randomness in two dimensions. For the q-state Potts model, we show that a line of renormalization group fixed points interpolates from weak to strong randomness as q-2 grows from small to large values. This theory exhibits a q-independent sector, and allows at the same time for a correlation length exponent which keeps the Ising value and continuously varying magnetization exponent and effective central charge. These findings appear to solve long-standing numerical and theoretical puzzles, and to illustrate the peculiarities which may characterize the conformal field theories of random fixed points...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28694830/erratum-to-do-epinephrine-auto-injectors-have-an-unsuitable-needle-length-in-children-and-adolescents-at-risk-for-anaphylaxis-from-food-allergy
#20
Sten Dreborg, Xia Wen, Laura Kim, Gina Tsai, Immaculate Nevis, Ryan Potts, Jack Chiu, Arunmozhi Dominic, Harold Kim
[This corrects the article DOI: 10.1186/s13223-016-0110-8.].
2017: Allergy, Asthma, and Clinical Immunology
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