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R Kirk Owens, Leah Y Carreon, Erica F Bisson, Mohamad Bydon, Eric A Potts, Steven D Glassman
BACKGROUND CONTEXT: Although lumbar disc herniation (LDH) classically presents with lower extremity radiculopathy, there are patients who have substantial associated back pain PURPOSE: To determine if patients with lumbar disc herniation (LDH) with substantial back pain improve with decompression alone. STUDY DESIGN: Longitudinal observational cohort PATIENT SAMPLE: Patients enrolled in the Quality and Outcomes Database (QOD) with LDH and a baseline back pain score ≥ 5 of 10 who underwent 1 or 2-level lumbar discectomy only OUTCOME MEASURES: Back and leg pain scores (0-10), Oswestry Disability Index (ODI), and EuroQoL 5D (EQ-5D)...
February 14, 2018: Spine Journal: Official Journal of the North American Spine Society
Jonathan Rychen, Davide Croci, Michel Roethlisberger, Erez Nossek, Matthew Potts, Ivan Radovanovic, Howard Riina, Luigi Mariani, Raphael Guzman, Daniel W Zumofen
OBJECTIVE: Minimally invasive alternatives to the pterional craniotomy include the minipterional and the supraorbital craniotomy (SOC). The latter is performed via either an eyebrow or an eyelid skin incision. The purpose of this systematic review was to analyze the type and the incidence of approach-related complications of these keyhole craniotomies. METHODS: We review pertinent publications retrieved by search in the PubMed/Medline database. Inclusion criteria were all full-text publications, abstracts, and posters in English, up to 2016, reporting clinical results...
February 13, 2018: World Neurosurgery
Chun Shing Kwok, Jessica Potts, Martha Gulati, Mirvat Alasnag, Muhammad Rashid, Ahmad Shoaib, Muhammad Ayyaz Ul Haq, Rodrigo Bagur, Mamas Andreas Mamas
Women who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse outcomes compared with men, but it is unknown whether gender affects early unplanned rehospitalization. We analyzed 832,753 patients who underwent PCI from 2013 to 2014 in the Nationwide Readmissions Database. We compared gender differences in incidences, predictors, causes, and cost of unplanned 30-day readmissions and examined the effect of co-morbidity. A total of 832,753 men and women who survived the index PCI and were not admitted for a planned readmission were included in the analysis...
January 10, 2018: American Journal of Cardiology
João R D Ramos, Rui Travasso, João Carvalho
The formation of a functional vascular network depends on biological, chemical, and physical processes being extremely well coordinated. Among them, the mechanical properties of the extracellular matrix and cell adhesion are fundamental to achieve a functional network of endothelial cells, able to fully cover a required domain. By the use of a Cellular Potts Model and Finite Element Method it is shown that there exists a range of values of endothelial traction forces, cell-cell adhesion, and matrix rigidities where the network can spontaneously be formed, and its properties are characterized...
January 2018: Physical Review. E
Mayara Grizotte-Lake, Shipra Vaishnava
Autophagy is genetically associated with inflammatory bowel disease (IBD); however, its role remains unclear in disease pathogenesis. Three recent studies reveal a novel cytoprotective role of autophagy during viral, bacterial, and protozoan-triggered IBD (Burger et al., 2018; Matsuzawa-Ishimoto et al., 2017; Pott et al., 2018).
February 14, 2018: Cell Host & Microbe
Chun Shing Kwok, Evangelos Kontopantelis, Tim Kinnaird, Jessica Potts, Muhammad Rashid, Ahmad Shoaib, James Nolan, Rodrigo Bagur, Mark A de Belder, Peter Ludman, Mamas A Mamas
BACKGROUND: Retroperitoneal hemorrhage (RH) is a rare bleeding complication of percutaneous coronary intervention, which can result as a consequence of femoral access or can occur spontaneously. This study aims to evaluate temporal changes in RH, its predictors, and clinical outcomes in a national cohort of patients undergoing percutaneous coronary intervention in the United Kingdom. METHODS AND RESULTS: We analyzed RH events in patients who underwent percutaneous coronary intervention between 2007 and 2014...
February 2018: Circulation. Cardiovascular Interventions
Debra Vincent, Jeanne Potts, Jessica Durbin, Jill M Moore, Susan Eley
Use of electronic nicotine delivery systems is flourishing among adolescents. The long-term effects have not been fully determined; however, literature suggests there is potential for significant harm. Providers must be aware of usage trends, device safety, and product knowledge. Adolescents should be evaluated through routine screening, and cessation counseling should be initiated.
March 12, 2018: Nurse Practitioner
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
Alexander Pott, Christoph Kraft, Tilman Stephan, Kerstin Petscher, Wolfgang Rottbauer, Tillman Dahme
BACKGROUND: The optimal freeze duration in cryoballoon pulmonary vein isolation (PVI) is unknown. The 3rd generation cryoballoon facilitates observation of the time-to-isolation (TTI) and thereby enables individualized cryoenergy titration. To evaluate the efficacy of an individualized freeze duration we compared the clinical outcome of patients treated with a TTI-guided ablation protocol to the outcome of patients treated with a fixed ablation protocol. METHODS: We compared 100 patients treated with the 3rd generation cryoballoon applying a TTI-based protocol (TTI group) to 100 patients treated by a fixed freeze protocol (fixed group)...
March 15, 2018: International Journal of Cardiology
Andrew R Levy, Bashir Matata, Sam Pilsworth, Adrian Mcgonigle, Lyndsey Wigelsworth, Linda Jones, Nicola Pott, Max Bettany, Adrian W Midgley
Background: Chronic obstructive pulmonary disease (COPD) is a degenerative condition that can impair health-related quality of life (HRQoL). A number of self-management interventions, employing a variety of behavioural change techniques (BCTs), have been adopted to improve HRQoL for COPD patients. However, a lack of attention has been given to group management interventions with an emphasis on incorporating BCTs into rehabilitators' practice. This study aims to pilot and feasibly explore a social identity group management intervention, delivered by COPD rehabilitation staff to patients attending exercise pulmonary rehabilitation...
2018: Pilot and Feasibility Studies
Hans Adrian Bunzel, Xavier Garrabou, Moritz Pott, Donald Hilvert
Exploring the sequence space of enzyme catalysts is ultimately a numbers game. Ultrahigh-throughput screening methods for rapid analysis of millions of variants are therefore increasingly important for investigating sequence-function relationships, searching large metagenomic libraries for interesting activities, and accelerating enzyme evolution in the laboratory. Recent applications of such technologies are reviewed here, with a particular focus on the practical benefits of droplet-based microfluidics for the directed evolution of natural and artificial enzymes...
January 29, 2018: Current Opinion in Structural Biology
C Obregón, A R Lyndon, J Barker, H Christiansen, B J Godley, S Kurland, J J Piccolo, R Potts, R Short, A Tebb, S Mariani
Research on the values of fish populations and fisheries has primarily focused on bio-economic aspects; a more nuanced and multidimensional perspective is mostly neglected. Although a range of social aspects is increasingly being considered in fisheries research, there is still no clear understanding as to how to include these additional values within management policies nor is there a cogent appreciation of the major knowledge gaps that should be tackled by future research. This paper results from a workshop held during the 50th anniversary symposium of the Fisheries Society of the British Isles at the University of Exeter, UK, in July 2017...
February 7, 2018: Journal of Fish Biology
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
January 30, 2018: Lancet Diabetes & Endocrinology
Lauren M Cantwell, John C Perkins, David C V Keyes
BACKGROUND: Tuberculosis (TB) is now rare in developed countries; however, it is an important diagnosis for the Emergency Physician to be able to make. Classically thought of as a respiratory disease, TB can present in other ways, making it more challenging to recognize. CASE REPORT: We report the case of a 41-year-old woman who presented to the Emergency Department with a 4-week history of back pain. A diagnosis of T12 osteomyelitis and right psoas muscle abscess was made after magnetic resonance imaging...
January 26, 2018: Journal of Emergency Medicine
Saloni P Sheth, Paul Ilkanich, Blaise Congeni
Fusobacterium infections and Lemierre Syndrome are traditionally associated with pharyngitis. We report three cases of Fusobacterium sinusitis that resulted in Pott Puffy Tumor. One of these cases also had Lemierre Syndrome. We encourage expansion of the clinical spectrum of Lemierre Syndrome to include complicated Fusobacterium sinusitis.
January 31, 2018: Pediatric Infectious Disease Journal
Vinay K Maurya, Pankaj Sharma, R Ravikumar, J Debnath, Vivek Sharma, Satyabrat Srikumar, Mukul Bhatia
Background: Tuberculosis of spine is known as tubercular spondylitis or Pott's spine. The vertebral involvement leads to various pathological processes such as abscess formation, cord compression, and gibbus deformity. Magnetic Resonance Imaging (MRI) is the imaging modality of choice which not only helps in diagnosing a case of Pott's spine but also gives valuable information about its impending complications, thereby, aiding in management of these cases. Methods: In this study, MRI scans of 80 proven cases of tubercular spondylitis were studied retrospectively for the various pathological processes affecting the spine...
January 2018: Medical Journal, Armed Forces India
Anne Conrad, Tristan Ferry, Florence Ader, Florent Valour
No abstract text is available yet for this article.
January 29, 2018: BMJ Case Reports
Jill B Firszt, Ruth M Reeder, Laura K Holden, Noël Y Dwyer, Brenda Gotter, Karen Mispagel, Lisa Potts, Sallie Vanderhoof, Tim Holden, Chris Brenner, Mike Strube, Craig Buchman, Richard Chole, Andrew Drescher, Joel Goebel, Tim Hullar, Jonathan McJunkin, Gail Neely, Lisa Cowdrey, Kristen Lewis, Heidi Frazier, Sarah Zlomke, Robert Cullen, Charles Luetje
OBJECTIVES: Asymmetric hearing with severe to profound hearing loss (SPHL) in one ear and better hearing in the other requires increased listening effort and is detrimental for understanding speech in noise and sound localization. Although a cochlear implant (CI) is the only treatment that can restore hearing to an ear with SPHL, current candidacy criteria often disallows this option for patients with asymmetric hearing. The present study aimed to evaluate longitudinal performance outcomes in a relatively large group of adults with asymmetric hearing who received a CI in the poor ear...
January 25, 2018: Ear and Hearing
Iliana Chollett, Rachel Collin, Carolina Bastidas, Aldo Cróquer, Peter M H Gayle, Eric Jordán-Dahlgren, Karen Koltes, Hazel Oxenford, Alberto Rodriguez-Ramirez, Ernesto Weil, Jahson Alemu, David Bone, Kenneth C Buchan, Marcia Creary Ford, Edgar Escalante-Mancera, Jaime Garzón-Ferreira, Hector M Guzmán, Björn Kjerfve, Eduardo Klein, Croy McCoy, Arthur C Potts, Francisco Ruíz-Rentería, Struan R Smith, John Tschirky, Jorge Cortés
[This corrects the article DOI: 10.1371/journal.pone.0188564.].
2018: PloS One
Ruth J Mitchell, Richard L Hewison, Debbie A Fielding, Julia M Fisher, Diana J Gilbert, Sonja Hurskainen, Robin J Pakeman, Jacqueline M Potts, David Riach
The predicted long lag time between a decrease in atmospheric deposition and a measured response in vegetation has generally excluded the investigation of vegetation recovery from the impacts of atmospheric deposition. However, policy-makers require such evidence to assess whether policy decisions to reduce emissions will have a positive impact on habitats. Here we have shown that 40 years after the peak of SOx emissions, decreases in SOx are related to significant changes in species richness and cover in Scottish Calcareous, Mestrophic, Nardus and Wet grasslands...
January 19, 2018: Environmental Pollution
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