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https://www.readbyqxmd.com/read/29690022/a-new-species-of-anheteromeyenia-porifera-demospongiae-with-an-emended-diagnosis-of-the-genus
#1
Ludimila Calheira, Ulisses Pinheiro
Anheteromeyenia Schröder, 1927 (Spongillidae) was erected to comprise species of Heteromeyenia Potts, 1881 without microscleres. Until now, only four species of Anheteromeyenia are known, three from the Neotropical Region (A. cheguevarai, A. ornata and A. vitrea) and A. argyrosperma from the Nearctic Region. In the present study, we describe a new species of Anheteromeyenia from the Neotropical Region, which differs from other congeners in having only one category of megascleres, exclusively smooth oxeas. An identification key to species of Anheteromeyenia and an emended diagnosis of the genus are provided...
February 7, 2018: Zootaxa
https://www.readbyqxmd.com/read/29680759/impact-of-genetically-modified-organisms-on-aquatic-environments-review-of-available-data-for-the-risk-assessment
#2
REVIEW
Antonia Pott, Mathias Otto, Ralf Schulz
The aquatic environment is strongly connected to the surrounding agricultural landscapes, which regularly serve as sources of stressors such as agrochemicals. Genetically modified crops, which are cultivated on a large scale in many countries, may also act as stressors. Despite the commercial use of genetically modified organisms (GMOs) for over 20years, their impact on the aquatic environment came into focus only 10years ago. We present the status quo of the available scientific data in order to provide an input for informed aquatic risk assessment of GMOs...
April 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29678701/seeing-floaters-a-case-report-and-literature-review-of-intraventricular-migration-of-silicone-oil-tamponade-material-for-retinal-detachment
#3
Matthew B Potts, Alex C Wu, David J Rusinak, Kartik Kesavabhotla, Babak S Jahromi
BACKGROUND: Intraocular injection of silicone oil is commonly performed during vitrectomy to tamponade the retina in place for treatment of retinal detachment. Although rare, this intravitreal silicone can migrate through the optic nerve and chiasm and enter the cerebral ventricles. CASE DESCRIPTION: Here we present a case report of a patient presenting with headache and intraventricular hyperdensities on computed tomography imaging raising concern for intraventricular hemorrhage...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29657079/functional-selectivity-of-cardiac-preganglionic-sympathetic-neurones-in-the-rabbit-heart
#4
Reshma A Chauhan, John Coote, Emily Allen, Pott Pongpaopattanakul, Kieran E Brack, G Andre Ng
BACKGROUND: Studies have shown regional and functional selectivity of cardiac postganglionic neurones indicating there might exist a similar heterogeneity in spinal segmental preganglionic neurones, which requires further investigation. METHODS: Right and left sympathetic chains were electrically stimulated from T6 to T1 in the innervated isolated rabbit heart preparation (n = 18). Sinus rate, left ventricular pressure, retrograde ventriculo-atrial conduction, monophasic action potential duration, effective refractory period, ventricular fibrillation threshold and electrical restitution were measured...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29656892/cancer-germline-antigen-expression-discriminates-clinical-outcome-to-ctla-4-blockade
#5
Sachet A Shukla, Pavan Bachireddy, Bastian Schilling, Christina Galonska, Qian Zhan, Clyde Bango, Rupert Langer, Patrick C Lee, Daniel Gusenleitner, Derin B Keskin, Mehrtash Babadi, Arman Mohammad, Andreas Gnirke, Kendell Clement, Zachary J Cartun, Eliezer M Van Allen, Diana Miao, Ying Huang, Alexandra Snyder, Taha Merghoub, Jedd D Wolchok, Levi A Garraway, Alexander Meissner, Jeffrey S Weber, Nir Hacohen, Donna Neuberg, Patrick R Potts, George F Murphy, Christine G Lian, Dirk Schadendorf, F Stephen Hodi, Catherine J Wu
CTLA-4 immune checkpoint blockade is clinically effective in a subset of patients with metastatic melanoma. We identify a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region of chromosome Xq28, that predicts resistance uniquely to blockade of CTLA-4, but not PD-1. We validate this gene expression signature in an independent anti-CTLA-4-treated cohort and show its specificity to the CTLA-4 pathway with two independent anti-PD-1-treated cohorts. Autophagy, a process critical for optimal anti-cancer immunity, has previously been shown to be suppressed by the MAGE-TRIM28 ubiquitin ligase in vitro...
April 6, 2018: Cell
https://www.readbyqxmd.com/read/29650343/safety-efficacy-and-management-of-subcutaneous-treprostinil-infusions-in-the-treatment-of-severe-pediatric-pulmonary-hypertension
#6
Marilyne Levy, Maria-Jesus Del Cerro, Sophie Nadaud, Karunakar Vadlamudi, Elizabeth Colgazier, Jeff Fineman, Damien Bonnet, Ian Adatia
BACKGROUND: Continuous intravenous epoprostenol was the first treatment approved for pulmonary arterial hypertension (PAH) but administration through a central venous line carries risks of thrombosis and sepsis, particularly in children. We sought to evaluate the safety, efficacy and management of subcutaneous (SC) treprostinil in children with PAH. METHODS: Fifty-six children (median age 65, range 1-200 months) were treated with SC treprostinil. Clinical status, echocardiography, NT-proBNP, and site pain and infection were evaluated...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29625566/passing-mrcp-uk-paces-a-cross-sectional-study-examining-the-performance-of-doctors-by-sex-and-country
#7
Emily Unwin, Henry W W Potts, Jane Dacre, Andrew Elder, Katherine Woolf
BACKGROUND: There is much discussion about the sex differences that exist in medical education. Research from the United Kingdom (UK) and United States has found female doctors earn less, and are less likely to be senior authors on academic papers, but female doctors are also less likely to be sanctioned, and have been found to perform better academically and clinically. It is also known that international medical graduates tend to perform more poorly academically compared to home-trained graduates in the UK, US, and Canada...
April 6, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29622145/burden-of-30-day-readmissions-after-percutaneous-coronary-intervention-in-833-344-patients-in-the-united-states-predictors-causes-and-cost-insights-from-the-nationwide-readmission-database
#8
Chun Shing Kwok, Sunil V Rao, Jessica E Potts, Evangelos Kontopantelis, Muhammad Rashid, Tim Kinnaird, Nick Curzen, James Nolan, Rodrigo Bagur, Mamas A Mamas
OBJECTIVES: This study aimed to examine the 30-day unplanned readmissions rate, predictors of readmission, causes of readmissions, and clinical impact of readmissions after percutaneous coronary intervention (PCI). BACKGROUND: Unplanned rehospitalizations following PCI carry significant burden to both patients and the local health care economy and are increasingly considered as an indicator of quality of care. METHODS: Patients undergoing PCI between 2013 and 2014 in the U...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29599472/examination-of-csr-regulatory-circuitry-using-epistasis-analysis-with-rna-seq-epi-seq-confirms-that-csrd-affects-gene-expression-via-csra-csrb-and-csrc
#9
Anastasia H Potts, Yuanyuan Leng, Paul Babitzke, Tony Romeo
The Csr global regulatory system coordinates gene expression in response to metabolic status. This system utilizes the RNA binding protein CsrA to regulate gene expression by binding to transcripts of structural and regulatory genes, thus affecting their structure, stability, translation, and/or transcription elongation. CsrA activity is controlled by sRNAs, CsrB and CsrC, which sequester CsrA away from other transcripts. CsrB/C levels are partly determined by their rates of turnover, which requires CsrD to render them susceptible to RNase E cleavage...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29597101/mother-to-child-transmission-of-hepatitis-c-virus
#10
REVIEW
Henrique Pott, Matheus Theodoro, Juliana de Almeida Vespoli, Jorge Figueiredo Senise, Adauto Castelo
Hepatitis C virus (HCV) infection is a worldwide health problem. Based on results of a serosurvey, global prevalence is estimated to be 2,5%, and women account for about 35.8% of the cases. For pregnant women the prevalence is lower and showed a range between 0.24% to 4.3%. Sinse mechanisms and timing of mother to child transmission are not fully understood, efforts are made to assess and understand its risk factors. The purpose of this review was to synthesize the evidence about the mother-to-child transmission of hepatitis C virus and review its risk factors...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29590547/ibrutinib-plus-venetoclax-for-the-treatment-of-mantle-cell-lymphoma
#11
COMPARATIVE STUDY
Constantine S Tam, Mary Ann Anderson, Christiane Pott, Rishu Agarwal, Sasanka Handunnetti, Rodney J Hicks, Kate Burbury, Gillian Turner, Juliana Di Iulio, Mathias Bressel, David Westerman, Stephen Lade, Martin Dreyling, Sarah-Jane Dawson, Mark A Dawson, John F Seymour, Andrew W Roberts
BACKGROUND: Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma. Complete response rates of 21% have been observed for each agent when administered as long-term continuous therapy. Preclinical models predict synergy in combination. METHODS: We conducted a single-group, phase 2 study of daily oral ibrutinib and venetoclax in patients, as compared with historical controls. Patients commenced ibrutinib monotherapy at a dose of 560 mg per day...
March 29, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29579392/template-assisted-scalable-nanowire-networks
#12
Martin Friedl, Kristopher Kristopher Cerveny, Pirmin Weigele, Gözde Tütüncüoglu, Sara Marti-Sanchez, Chunyi Huang, Taras Patlatiuk, Heidi Potts, Zhiyuan Sun, Megan O Hill, Lucas Güniat, Wonjong Kim, Mahdi Zamani, Vladimir G Dubrovskii, Jordi Arbiol, Lincoln J Lauhon, Dominik Max Zumbühl, Anna Fontcuberta I Morral
Topological qubits based on Majorana fermions have the potential to revolutionize the emerging field of quantum computing by making information processing significantly more robust to decoherence. Nanowires (NWs) are a promising medium for hosting these kinds of qubits, though branched NWs are needed to perform qubit manipulations.3 Here we report gold-free templated growth of III-V NWs by molecular beam epitaxy using an approach that enables patternable and highly regular branched NW arrays on a far greater scale than what has been reported thus far...
March 26, 2018: Nano Letters
https://www.readbyqxmd.com/read/29578722/anisotropic-strain-induced-bandgap-engineering-in-nanowire-based-quantum-dots
#13
Luca Francaviglia, Andrea Giunto, Wonjong Kim, Pablo Romero, Jelena Vukajlovic-Plestina, Martin Friedl, Heidi Potts, Lucas Güniat, Gözde Tütüncüoglu, Anna Fontcuberta I Morral
Tuning light emission in bulk and quantum structures by strain constitutes a complementary method to engineer functional properties of semiconductors. Here, we demonstrate the tuning of light emission of GaAs nanowires and their quantum dots up to 115 meV by applying strain through an oxide envelope. We prove that the strain is highly anisotropic and clearly results in a component along the NW longitudinal axis, showing good agreement with the equations of uniaxial stress. We further demonstrate that the strain strongly depends on the oxide thickness, the oxide intrinsic strain, and the oxide microstructure...
March 26, 2018: Nano Letters
https://www.readbyqxmd.com/read/29578031/the-unc-umn-baby-connectome-project-bcp-an-overview-of-the-study-design-and-protocol-development
#14
REVIEW
Brittany R Howell, Martin A Styner, Wei Gao, Pew-Thian Yap, Li Wang, Kristine Baluyot, Essa Yacoub, Geng Chen, Taylor Potts, Andrew Salzwedel, Gang Li, John H Gilmore, Joseph Piven, J Keith Smith, Dinggang Shen, Kamil Ugurbil, Hongtu Zhu, Weili Lin, Jed T Elison
The human brain undergoes extensive and dynamic growth during the first years of life. The UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects funded by NIH, is an ongoing study jointly conducted by investigators at the University of North Carolina at Chapel Hill and the University of Minnesota. The primary objective of the BCP is to characterize brain and behavioral development in typically developing infants across the first 5 years of life. The ultimate goals are to chart emerging patterns of structural and functional connectivity during this period, map brain-behavior associations, and establish a foundation from which to further explore trajectories of health and disease...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29576927/encapsulated-cell-technology-based-delivery-of-a-complement-inhibitor-reduces-choroidal-neovascularization-in-a-mouse-model
#15
Balasubramaniam Annamalai, Nathaniel Parsons, Marwa Belhaj, Carlene Brandon, Jay Potts, Bärbel Rohrer
Purpose: Age-related macular degeneration (AMD) is a slowly progressing disease, and risk appears to be tied to an overactive complement system. We have previously demonstrated that mouse choroidal neovascularization (CNV) and smoke-induced ocular pathology can be reduced with an alternative pathway (AP) inhibitor fusion protein consisting of a complement receptor-2 fragment linked to the inhibitory domain of factor H (CR2-fH) when delivered systemically. Here we developed an experimental approach with genetically engineered encapsulated ARPE-19 cells to produce CR2-fH intravitreally...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29570769/low-hair-cortisol-concentration-and-emerging-attention-deficit-hyperactivity-symptoms-in-preschool-age
#16
Susan Schloß, Isabelle Ruhl, Viola Müller, Katja Becker, Nadine Skoluda, Urs M Nater, Ursula Pauli-Pott
Previous research demonstrated hypoactivity of the HPA axis in children with attention-deficit/hyperactivity disorder (ADHD) or externalizing symptoms. We analyzed the predictive association between the long-term HPA axis activity and increasing symptoms of ADHD in the preschool period. The sample consisted of n = 125 4-year-old children and their families (including n = 64 children with elevated ADHD symptoms). ADHD symptoms were assessed by a structured clinical interview with the mother and by parent- and teacher-report questionnaires...
March 23, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29565190/prevalence-of-genital-psoriasis-in-patients-with-psoriasis
#17
Kim A P Meeuwis, Alison Potts Bleakman, Peter C M van de Kerkhof, Yves Dutronc, Carsten Henneges, Lori J Kornberg, Alan Menter
BACKGROUND: Psoriatic lesions in the genital area (GenPs) can cause considerable physical and emotional distress. To increase physician awareness, we estimated the GenPs prevalence among patients with psoriasis. METHODS: An English language literature search was performed. Articles reporting GenPs prevalence met the search criteria and were included. Because GenPs is rarely reported in demographics of prospective clinical trials, GenPs prevalence and baseline demographics of patients with and without GenPs in 2 prospective randomized phase 3b trials (NCT02561806; NCT02634801) involving patients with moderate-to-severe psoriasis are reported...
March 22, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29560854/moving-epidemic-method-mem-applied-to-virology-data-as-a-novel-real-time-tool-to-predict-peak-in-seasonal-influenza-healthcare-utilisation-the-scottish-experience-of-the-2017-18-season-to-date
#18
Josephine L K Murray, Diogo F P Marques, Ross L Cameron, Alison Potts, Jennifer Bishop, Beatrix von Wissmann, Naoma William, Arlene J Reynolds, Chris Robertson, Jim McMenamin
Scotland observed an unusual influenza A(H3N2)-dominated 2017/18 influenza season with healthcare services under significant pressure. We report the application of the moving epidemic method (MEM) to virology data as a tool to predict the influenza peak activity period and peak week of swab positivity in the current season. This novel MEM application has been successful locally and is believed to be of potential use to other countries for healthcare planning and building wider community resilience.
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29559196/doppler-echocardiography-assessment-of-aortic-stiffness-in-female-adolescents-with-anorexia-nervosa
#19
Carolina A Escudero, James E Potts, Pei-Yoong Lam, Astrid M De Souza, Gerald J Mugford, George G S Sandor
BACKGROUND: Anorexia nervosa (AN) is associated with abnormalities in biomarkers of cardiovascular risk. Arterial stiffness, as measured by pulse-wave velocity (PWV), is also a risk factor for cardiovascular disease. The aims of this study were to determine the stiffness of the aorta in female adolescents with AN and to determine if either the severity or the type of AN was associated with PWV. METHODS: This was a retrospective case-control study. Adolescent patients with a clinical diagnosis of AN were included...
March 17, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29555640/ashp-ppag-guidelines-for-providing-pediatric-pharmacy-services-in-hospitals-and-health-systems
#20
Lea S Eiland, Kim Benner, Karl F Gumpper, Melissa K Heigham, Rachel Meyers, Katherine Pham, Amy L Potts
No abstract text is available yet for this article.
March 19, 2018: American Journal of Health-system Pharmacy: AJHP
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