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https://www.readbyqxmd.com/read/28642363/nuclear-phosphorylated-dicer-processes-double-stranded-rna-in-response-to-dna-damage
#1
Kaspar Burger, Margarita Schlackow, Martin Potts, Svenja Hester, Shabaz Mohammed, Monika Gullerova
The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates small noncoding RNA to mediate the DNA damage response (DDR). Here, we show that human Dicer is phosphorylated in the platform-Piwi/Argonaute/Zwille-connector helix cassette (S1016) upon induction of DNA damage. Phosphorylated Dicer (p-Dicer) accumulates in the nucleus and is recruited to DNA double-strand breaks...
June 22, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28641257/fast-segmentation-from-blurred-data-in-3d-fluorescence-microscopy
#2
Martin Storath, Dennis Rickert, Michael Unser, Andreas Weinmann
We develop a fast algorithm for segmenting 3D images from linear measurements based on the Potts model (or piecewise constant Mumford-Shah model). To that end, we first derive suitable space discretizations of the 3D Potts model which are capable of dealing with 3D images defined on non-cubic grids. Our discretization allows us to utilize a specific splitting approach which results in decoupled subproblems of moderate size. The crucial point in the 3D setup is that the number of independent subproblems is so large that we can reasonably exploit the parallel processing capabilities of the graphics processing units (GPU)...
June 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28638545/program-performance-in-the-next-accreditation-system-nas-results-of-the-2015-2016-annual-data-review
#3
Lauren M Byrne, Rebecca S Miller, Ingrid Philibert, Louis J Ling, John R Potts, Mary W Lieh-Lai, Thomas J Nasca
No abstract text is available yet for this article.
June 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28633765/neck-dissection-for-unknown-cancer-of-the-head-and-neck-in-the-era-of-chemoradiation
#4
Mark J Amsbaugh, Mehran Yusuf, Jeremy Gaskins, Craig Silverman, Kevin Potts, Jeffrey Bumpous, Rebecca Redman, Cesar Perez, Neal Dunlap
PURPOSE: To report outcomes for patients with cervical lymph node metastases from an unknown primary site of the head and neck treated with either non-operative therapy or neck dissection followed by adjuvant therapy. MATERIALS AND METHODS: All patients with squamous cell carcinoma of an unknown primary site of the head or neck seen between 2003 and 2013 were reviewed. The Kaplan-Meier method was used to estimate overall survival, local recurrence free survival, loco-regional recurrence free survival, and progression free survival...
June 14, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28633268/surgical-interventional-hybrid-concept-in-a-newborn-with-borderline-left-heart
#5
Stefan Rupp, Josef Thul, Kerstin Gummel, Markus Khalil, Hakan Akintuerk, Dietmar Schranz
Through a series of complex surgical and interventional procedures including downsizing of an unrestricted atrial septal defect, aortic arch reconstruction, pulmonary artery banding, reversed Potts shunt, and Melody valve in a mitral position, biventricular conversion was successfully achieved in a patient with a distinct borderline left ventricle. By use of these interventional steps, flow-mediated and load-mediated growth of a small left ventricle was observed, highlighting the plasticity of hearts in growing children...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28633267/perventricular-implantation-of-melody-valve-in-child-with-pulmonary-hypertension-after-a-potts-shunt
#6
Tomasz Mroczek, Marcin Demkow, Tomasz Moszura, Aleksandra Morka, Janusz Skalski
The Potts operation is a surgical option for the treatment of children with suprasystemic pulmonary arterial hypertension (PAH). Its positive hemodynamic effect may be obliterated by pulmonary valvar insufficiency. We describe a case in which the Potts shunt was followed by perventricular Melody valve implantation in the pulmonary position in a 12-kg child with a previously repaired truncus arteriosus communis (TAC) in whom PAH developed. The combined approach using both procedures significantly improved functional capacity and led to spectacular reverse remodeling of the right ventricle seen at 2-year follow-up...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28632644/do-former-smokers-exhibit-a-distinct-profile-before-and-after-lumbar-spine-surgery
#7
Ehsan Jazini, Steven D Glassman, Erica F Bisson, Eric A Potts, Leah Y Carreon
STUDY DESIGN: Retrospective longitudinal cohort OBJECTIVES.: To determine if former smokers undergoing lumbar spine surgery have distinct baseline and post-operative Patient Reported Outcomes (PROs) compared to never smokers and current smokers SUMMARY OF BACKGROUND DATA.: Smoking has known deleterious effects on patients undergoing lumbar spine surgery. However, former smokers have not been extensively evaluated. There are few studies regarding the relationship between pack-years or duration of smoking cessation, and subsequent clinical outcome...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28626295/restoring-effective-sleep-tranquility-rest-a-feasibility-and-pilot-study
#8
Aaron M Eakman, Arlene A Schmid, Kimberly L Henry, Natalie R Rolle, Catherine Schelly, Christine E Pott, Joshua E Burns
INTRODUCTION: The purpose of this pilot study was to establish the feasibility of completing a future controlled trial of a multi-component cognitive behavioral therapy for insomnia program for military veterans with sleep disturbance. METHOD: This was a single-arm feasibility and pilot study. Participants were United States post-9/11 veterans with service-connected injuries, university students, and had self-reported sleep disturbances. Restoring Effective Sleep Tranquility was a multi-component cognitive behavioral therapy for insomnia intervention consisting of seven sessions of group therapy and eight 1:1 sessions delivered by occupational therapists...
June 2017: British Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28626083/cellular-and-disease-functions-of-the-prader-willi-syndrome-gene-magel2
#9
REVIEW
Klementina Fon Tacer, Patrick Ryan Potts
Melanoma antigen L2 (MAGEL2 or MAGE-L2) is a member of the MAGE family of ubiquitin ligase regulators. It is maternally imprinted and often paternally deleted or mutated in the related neurodevelopmental syndromes, Prader-Willi Syndrome (PWS) and Schaaf-Yang Syndrome (SHFYNG). MAGEL2 is highly expressed in the hypothalamus and plays an important role in a fundamental cellular process that recycles membrane proteins from endosomes through the retromer sorting pathway. MAGEL2 is part of a multi-subunit protein complex consisting of MAGEL2, the TRIM27 E3 ubiquitin ligase, and the USP7 deubiquitinating enzyme...
June 16, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28617667/a-heuristic-computational-model-of-basic-cellular-processes-and-oxygenation-during-spheroid-dependent-biofabrication
#10
T J Sego, U Kasacheuski, D Hauersperger, A Tovar, N I Moldovan
An emerging approach in biofabrication is the creation of 3D tissue constructs through scaffold-free, cell spheroid-only methods. The basic mechanism in this technology is spheroid fusion, which is driven by the minimization of energy, the same biophysical mechanism that governs spheroid formation. However, other factors such as oxygen and metabolite accessibility within spheroids impact on spheroid properties and their ability to form larger-scale structures. The goal of our work is to develop a simulation platform eventually capable of predicting the conditions that minimize metabolism-related cell loss within spheroids...
June 15, 2017: Biofabrication
https://www.readbyqxmd.com/read/28615918/lung-cancer-pathological-image-analysis-using-a-hidden-potts-model
#11
Qianyun Li, Faliu Yi, Tao Wang, Guanghua Xiao, Faming Liang
Nowadays, many biological data are acquired via images. In this article, we study the pathological images scanned from 205 patients with lung cancer with the goal to find out the relationship between the survival time and the spatial distribution of different types of cells, including lymphocyte, stroma, and tumor cells. Toward this goal, we model the spatial distribution of different types of cells using a modified Potts model for which the parameters represent interactions between different types of cells and estimate the parameters of the Potts model using the double Metropolis-Hastings algorithm...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28615631/inverse-problem-for-multi-body-interaction-of-nonlinear-waves
#12
Alessia Marruzzo, Payal Tyagi, Fabrizio Antenucci, Andrea Pagnani, Luca Leuzzi
The inverse problem is studied in multi-body systems with nonlinear dynamics representing, e.g., phase-locked wave systems, standard multimode and random lasers. Using a general model for four-body interacting complex-valued variables we test two methods based on pseudolikelihood, respectively with regularization and with decimation, to determine the coupling constants from sets of measured configurations. We test statistical inference predictions for increasing number of sampled configurations and for an externally tunable temperature-like parameter mimicing real data noise and helping minimization procedures...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613909/engineering-the-size-distributions-of-ordered-gaas-nanowires-on-silicon
#13
Jelena Vukajlovic-Plestina, Wonjong Kim, Vladimir G Dubrovskii, Gözde Tütüncüoglu, Maxime Lagier, Heidi Potts, Martin Friedl, Anna Fontcuberta I Morral
Reproducible integration of III-V semiconductors on silicon can open new path toward CMOS compatible optoelectronics and novel design schemes in next generation solar cells. Ordered arrays of nanowires could accomplish this task, provided they are obtained in high yield and uniformity. In this work, we provide understanding on the physical factors affecting size uniformity in ordered GaAs arrays grown on silicon. We show that the length and diameter distributions in the initial stage of growth are not much influenced by the Poissonian fluctuation-induced broadening, but rather are determined by the long incubation stage...
June 14, 2017: Nano Letters
https://www.readbyqxmd.com/read/28606815/predictors-of-self-and-parental-vaccination-decisions-in-england-during-the-2009-h1n1-pandemic-analysis-of-the-flu-watch-pandemic-cohort-data
#14
Dale Weston, Ruth Blackburn, Henry W W Potts, Andrew C Hayward
During the 2009 H1N1 pandemic, UK uptake of the pandemic influenza vaccine was very low. Furthermore, attitudes governing UK vaccination uptake during a pandemic are poorly characterised. To the best of our knowledge, there is no published research explicitly considering predictors of both adult self-vaccination and decisions regarding whether or not to vaccinate one's children among the UK population during the H1N1 pandemic. We therefore aimed to identify predictors of both self-vaccination decisions and parental vaccination decisions using data collected during the H1N1 pandemic as part of the Flu Watch cohort study...
June 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28599828/a-doppler-echocardiographic-study-of-the-myocardial-inotropic-response-to-peak-semisupine-exercise-in-healthy-children-development-of-a-simplified-index-of%C3%A2-myocardial%C3%A2-reserve
#15
Anita T Cote, D Kathryn Duff, Carolina A Escudero, Astrid M De Souza, Lindsey D Williams, Raman Gill, M Terri Zadorsky, Kevin C Harris, James E Potts, George G S Sandor
BACKGROUND: Stress echocardiography has been advocated for the detection of abnormal myocardial function and unmasking diminished myocardial reserve in pediatric patients. The aim of this study was to create a simplified index of myocardial reserve, derived from the myocardial inotropic response to peak semisupine exercise in healthy children, and illustrate its applicability in a sample of pediatric oncology patients. METHODS: In this prospective analysis, children (7-18 years of age) with normal cardiac structure and function performed semisupine stress echocardiography to volitional fatigue...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28593653/cellular-potts-modeling-of-complex-multicellular-behaviors-in-tissue-morphogenesis
#16
REVIEW
Tsuyoshi Hirashima, Elisabeth G Rens, Roeland M H Merks
Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier-Graner-Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation...
June 8, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28586341/erratum-oncostatin-m-drives-intestinal-inflammation-and-predicts-response-to-tumor-necrosis-factor-neutralizing-therapy-in-patients-with-inflammatory-bowel-disease
#17
Nathaniel R West, Ahmed N Hegazy, Benjamin M J Owens, Samuel J Bullers, Bryan Linggi, Sofia Buonocore, Margherita Coccia, Dieter Görtz, Sébastien This, Krista Stockenhuber, Johanna Pott, Matthias Friedrich, Grigory Ryzhakov, Frédéric Baribaud, Carrie Brodmerkel, Constanze Cieluch, Nahid Rahman, Gerhard Müller-Newen, Raymond J Owens, Anja A Kühl, Kevin J Maloy, Scott E Plevy, Satish Keshav, Simon P L Travis, Fiona Powrie
No abstract text is available yet for this article.
June 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28573743/impact-of-ixekizumab-treatment-on-skin-related-personal-relationship-difficulties-in-moderate-to-severe-psoriasis-patients-12-week-results-from-two-phase-3-trials
#18
L Guenther, R B Warren, J C Cather, H Sofen, Y Poulin, M Lebwohl, T Terui, A Potts Bleakman, B Zhu, R Burge, K Reich, P van de Kerkhof
BACKGROUND: Psoriasis symptoms may decrease quality of life for patients. Skin-related personal relationship difficulties in psoriasis patients are common, under-reported, and poorly understood. OBJECTIVE: To assess the effect of ixekizumab (IXE) treatment on skin-related personal relationship difficulties in patients with moderate-to-severe psoriasis. METHODS: Pooled data (N=2570) on skin-related relationship problems were obtained from two large phase 3 trials (UNCOVER-2 and UNCOVER-3) in patients with moderate-to-severe plaque psoriasis randomized to subcutaneous placebo (PBO, N=361), etanercept (ETN; 50 mg twice weekly, N=740), or 80 mg IXE as one injection every 4 (IXEQ4W, N=733) or 2 weeks (IXEQ2W, N=736) for 12 weeks, following a 160-mg initial dose...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28567156/surgical-treatment-of-angular-pott-s-kyphosis-with-posterior-approach-pedicular-wedge-osteotomy-and-canal-widening
#19
C V Kinkpe, M Onimus, L Sarr, M M Niane, M M Traore, M Daffe, A B Gueye
BACKGROUND: It has been observed that the correction of severe posttuberculous angular kyphosis is still a challenge, mainly because of the neurologic risk. METHODS: Nine patients were reviewed after surgery (mean follow-up 18 months). There were 2 thoracic, 4 thoraco-lumbar and 3 lumbar kyphosis. The mean age at surgery was 23. Clinical results were evaluated by the Oswestry Disability Index (ODI) and by the neurologic evaluation. Preoperative, postoperative and final follow-up X-rays were assessed...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28562520/langerhans-cell-histiocytosis-mimicking-a-pott-puffy-tumor
#20
Luca Pasquini, Maria Camilla Rossi Espagnet, Giacomo Esposito, Rita De Vito, Raffaella Messina, Stefania Gaspari, Daniela Longo
Langherans' cell histiocytosis (LCH) is a rare disease mostly affecting children in the first decade of life. As clinical presentation is extremely heterogenous, a prompt diagnosis may be challenging, sometimes leading to a diagnostic delay, especially when the disease involves a single site. Herein, we report a case of a child with an unusual presentation of (LCH) mimicking a Pott puffy tumor with extracranial and epidural abscesses, surgically treated. Through this unique case we summarize possible manifestations of LCH with bone involvement and we underline the importance of considering possible complications due to bone erosions such as infection, to avoid a misdiagnosis...
May 29, 2017: Journal of Pediatric Hematology/oncology
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