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https://www.readbyqxmd.com/read/28316224/-relief-effect-of-ct-guided-125-i-seed-implantation-on-patients-with-spinal-and-paraspinal-osteolytic-metastatic-tumors
#1
H Huang, F S Li, L Wang, Z G Du, S N Xu
Objective: To evaluate the clinical value of computed tomography (CT)-guided (125)I seed implantation in the treatment of patients with spinal and/or paraspinal osteolytic metastatic tumors. Methods: The radiation dose distribution was planned for 27 patients with 35 spinal and paraspinal osteolytic metastatic tumors by a treatment planning system (TPS). CT-guided (125)I seed implantation was carried out in the patients, and the quality of treatment was evaluated based on CT-imaging follow-up. Results: All the 27 patients underwent CT-guided (125)I seed implantation successfully...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28301268/efficacy-and-toxicity-profiles-of-two-chemoradiotherapies-for-stage-ii-laryngeal-cancer-a-comparison-between-late-course-accelerated-hyperfractionation-lcahf-and-conventional-fractionation-cf
#2
Eiichiro Okazaki, Naoki Matsushita, Mari Tashiro, Yasuhiko Shimatani, Kentaro Ishii, Masako Hosono, Masahiro Oishi, Yuichi Teranishi, Hiroyoshi Iguchi, Yukio Miki
OBJECTIVE: To evaluate the treatment results of late course accelerated hyperfractionation (LCAHF) compared with conventional fractionation (CF) for stage II laryngeal cancer. METHODS: Fifty-nine consecutive patients treated for stage II laryngeal cancer were retrospectively reviewed. Thirty-two patients underwent LCAHF, twice-daily fractions during the latter half with a total dose of 69 Gy. Twenty-seven patients received CF of 70 Gy. RESULTS: The local control rates (LCRs), overall survival (OS), and disease-specific survival (DSS) at 5 years were 80...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28283059/stress-triggered-phase-separation-is-an-adaptive-evolutionarily-tuned-response
#3
Joshua A Riback, Christopher D Katanski, Jamie L Kear-Scott, Evgeny V Pilipenko, Alexandra E Rojek, Tobin R Sosnick, D Allan Drummond
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels, and other assemblies lacking fixed stoichiometry. Observing these phenomena has generally required conditions far removed from physiological stresses. We show that poly(A)-binding protein (Pab1 in yeast), a defining marker of stress granules, phase separates and forms hydrogels in vitro upon exposure to physiological stress conditions...
March 9, 2017: Cell
https://www.readbyqxmd.com/read/28269241/label-free-detection-of-sex-determining-region-y-sry-via-capacitive-biosensor
#4
Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes. This section of genetic code, which is found on the Y chromosome, finds importance for study as it causes fetuses to develop characteristics of male sex-like gonads when a mutation occurs. It is also an important genetic code in men, and disorders involving the SRY gene can cause infertility and sexual malfunction that lead to a variety of gene mutational disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28245287/study-of-association-and-molecular-analysis-of-human-papillomavirus-in-breast-cancer-of-indian-patients-clinical-and-prognostic-implication
#5
Saimul Islam, Hemantika Dasgupta, Anirban Roychowdhury, Rittwika Bhattacharya, Nupur Mukherjee, Anup Roy, Gautam Kumar Mandal, Neyaz Alam, Jaydip Biswas, Shyamsundar Mandal, Susanta Roychoudhury, Chinmay Kumar Panda
OBJECTIVES: Human papillomavirus (HPV) causes tumors primarily Cervical cancer. Recently, inconsistent reports came up in Breast cancer (BC) too. In India, despite treatment 70,218 BC patients die each year. So, we explored the association of HPV, if any, with BC prognosis in Indian pre-therapeutic (PT) and Neo-adjuvant chemotherapy (NACT) patients with subsequent analysis of HPV profile. METHODS: HPV prevalence was checked and analysis of physical status, copy number, genome variation, promoter methylation and expression (mRNA and protein) of the prevalent subtype was done...
2017: PloS One
https://www.readbyqxmd.com/read/28227475/label-free-detection-of-sex-determining-region-y-sry-via-capacitive-biosensor
#6
Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama, Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama, Khaled Nabil Salama, Shilpa Sivashankar, Sumeyra Agambayev, Christos Sapsanis, Ulrich Buttner
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes. This section of genetic code, which is found on the Y chromosome, finds importance for study as it causes fetuses to develop characteristics of male sex-like gonads when a mutation occurs. It is also an important genetic code in men, and disorders involving the SRY gene can cause infertility and sexual malfunction that lead to a variety of gene mutational disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28218728/compliment-graphene-oxide-coating-on-silk-fiber-surface-via-electrostatic-force-for-capacitive-humidity-sensor-applications
#7
Kook In Han, Seungdu Kim, In Gyu Lee, Jong Pil Kim, Jung-Ha Kim, Suck Won Hong, Byung Jin Cho, Wan Sik Hwang
Cylindrical silk fiber (SF) was coated with Graphene oxide (GO) for capacitive humidity sensor applications. Negatively charged GO in the solution was attracted to the positively charged SF surface via electrostatic force without any help from adhesive intermediates. The magnitude of the positively charged SF surface was controlled through the static electricity charges created on the SF surface. The GO coating ability on the SF improved as the SF's positive charge increased. The GO-coated SFs at various conditions were characterized using an optical microscope, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), Raman spectroscopy, and LCR meter...
February 19, 2017: Sensors
https://www.readbyqxmd.com/read/28161276/erythroid-specific-activator-gata-1-dependent-interactions-between-ctcf-sites-around-the-%C3%AE-globin-locus
#8
Yujin Kang, Yea Woon Kim, Jin Kang, Won Ju Yun, AeRi Kim
CTCF sites (binding motifs for CCCTC-binding factor, an insulator protein) are located considerable distances apart on genomes but are closely positioned in organized chromatin. The close positioning of CTCF sites is often cell type or tissue specific. Here we analyzed chromatin organization in eight CTCF sites around the β-globin locus by 3C assay and explored the roles of erythroid specific transcription activator GATA-1 and KLF1 in it. It was found five CTCF sites convergent to the locus interact with each other in erythroid K562 cells but not in non-erythroid 293 cells...
February 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28141745/deferasirox-iron-complex-formation-ratio-as-an-indicator-of-long-term-chelation-efficacy-in-%C3%AE-thalassemia-major
#9
Meng-Yao Lu, Ting-Hao Lin, Po-Hung Chiang, Pei-Hsin Kuo, Ning Wang, Wen-Hsin Wu, Kai-Hsin Lin, Tzu-Hua Wu
BACKGROUND: β-Thalassemia major patients with higher total drug levels [deferasirox (DEFR) plus its iron complex] do not yield better serum ferritin (SF) control. This study aimed to determine the concentrations of DEFR and its iron complex (Fe-[DEFR]2) in thalassemia patients to predict the chelation efficacy in terms of SF and cardiac T2* values. METHODS: Patients' steady-state drug levels at trough (Ctrough) and 2 hours postdose (C2h) were determined. Because iron deposition may cause changes in the hepatic metabolism of amino acids, the concentrations of 40 amino acids in plasma were also assayed at 2 hours postdose...
April 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28028845/genomewide-snp-data-reveal-cryptic-phylogeographic-structure-and-microallopatric-divergence-in-a-rapids-adapted-clade-of-cichlids-from-the-congo-river
#10
S Elizabeth Alter, Jason Munshi-South, Melanie L J Stiassny
The lower Congo River is a freshwater biodiversity hot spot in Africa characterized by some of the world's largest rapids. However, little is known about the evolutionary forces shaping this diversity, which include numerous endemic fishes. We investigated phylogeographic relationships in Teleogramma, a small clade of rheophilic cichlids, in the context of regional geography and hydrology. Previous studies have been unable to resolve phylogenetic relationships within Teleogramma due to lack of variation in nuclear genes and discrete morphological characters among putative species...
December 28, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28026147/development-of-a-novel-immobilization-method-by-using-microgels-to-keep-enzyme-in-hydrated-microenvironment-in-porous-hydrophobic-membranes
#11
Giuseppe Vitola, Dominic Büning, Jens Schumacher, Rosalinda Mazzei, Lidietta Giorno, Mathias Ulbricht
Using colloidal polyacrylamide (PAAm) microgels as carriers, a novel strategy for covalent immobilization of enzymes maintained in hydrated microenvironment on/in a macroporous surface-functionalized hydrophobic polyvinylidene fluoride (PVDF) membrane is developed. The PAAm microgels are synthesized by inverse miniemulsion polymerization, and first the parameters are investigated which are suited to obtain particles in the desired size range, 100-200 nm, with narrow size distribution. Amino functions are then imparted to the microgels applying the Hofmann reaction...
December 27, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28004846/short-term-economic-impact-of-the-zika-virus-outbreak
#12
Daniele Macciocchi, Simone Lanini, Francesco Vairo, Alimuddin Zumla, Luiz Tadeu Moraes Figueiredo, Francesco Nicola Lauria, Gino Strada, Philippe Brouqui, Vincenzo Puro, Sanjeev Krishna, Peter Kremsner, Paola Scognamiglio, Carsten Köhler, Emanuele Nicastri, Antonino Di Caro, Rodolfo Maria Cieri, John P A Ioannidis, Gary Kobinger, Marcelo Nascimento Burattini, Giuseppe Ippolito
Zika virus (ZIKV) is mainly transmitted by mosquitoes bites. However, transmission by sexual contacts has been reported in 11 non endemic countries. The rapid spread of ZIKV in Latin American and Caribbean Countries (LCR), person-to-person transmission and perceived risk on people's well being can affect the emerging economies of LCR which historically dependent on truism. Here we present an analysis on economic outputs for assessing the current impact of ZIKV on markets. Our analysis show an unexpected resilience of LCR markets to international alerts...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27998803/a-pilot-study-on-hla-g-locus-control-region-haplotypes-and-cervical-intraepithelial-neoplasias
#13
Juliana Cochesnki Cordeiro, Jose Samuel da Silva, Valeria Sperandio Roxo, Maria da Graça Bicalho
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasias (CIN) grades 1, 2 and 3. Untreated, these lesions may progress to cervical cancer (CC) which is the third most common cancer in women worldwide. HLA-G plays an immunotolerant role in the immune response. The aim of this study was to characterize the configuration of SNPs located at the distal promoter of HLA-G in patients with CIN2 and CIN3 and control women. The study sample was composed of 207 women as follows: 73 diagnosed with CIN2 lesions, 56 with CIN3 and 78 healthy control women...
December 18, 2016: Human Immunology
https://www.readbyqxmd.com/read/27939161/epidemiologic-analysis-of-a-sarcoid-outbreak-involving-12-of-111-donkeys-in-northern-italy
#14
Hans Abel-Reichwald, Edmund K Hainisch, Sophie Zahalka, Annunziata Corteggio, Giuseppe Borzacchiello, Barbara Massa, Luca Merlone, Lubna Nasir, Faith Burden, Sabine Brandt
Equine sarcoids develop upon bovine papillomavirus type 1 or 2 (BPV1, BPV2) infection in conjunction with trauma and represent the most common tumour disease in horses and other equids, including donkeys. In face of a sarcoid outbreak involving 12 of 111 donkeys and mules at the 'Rifugio degli Asinelli', a subsidiary charity organization of The Donkey Sanctuary, non-invasively collected sample material including crusts, dandruff, swabs and hair roots was collected from sarcoid-affected and 26 healthy donkeys, as well as dandruff from a grooming kit and tabanids caught from or in the vicinity of sarcoid patients...
November 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27936752/high-aerobic-capacity-mitigates-changes-in-the-plasma-metabolomic-profile-associated-with-aging
#15
Oluyemi S Falegan, Hans J Vogel, Dustin S Hittel, Lauren G Koch, Steven L Britton, Russ T Hepple, Jane Shearer
Advancing age is associated with declines in maximal oxygen consumption. Declines in aerobic capacity not only contribute to the aging process but also are an independent risk factor for morbidity, cardiovascular disease, and all-cause mortality. Although statistically convincing, the relationships between aerobic capacity, aging, and disease risk remain largely unresolved. To this end, we employed sensitive, system-based metabolomics approach to determine whether enhanced aerobic capacity could mitigate some of the changes seen in the plasma metabolomic profile associated with aging...
December 19, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27862350/establishment-of-complete-blood-count-reference-intervals-for-chinese-preschoolers
#16
Guo-Cheng Wang, Na Li, Cui Niu, Wei-Bo Ma, Zhu-Liang Wang, Hao Guo, Li-Hong Han
BACKGROUND: Reference intervals are critical for interpreting test results of a clinical laboratory. The aim of this study was to establish local reference intervals of complete blood count for healthy preschoolers in China. METHODS: Three thousand eight hundred and twenty-one blood specimens from children aged 4 months to 6 years were collected and analyzed. Complete blood counts were determined by Sysmex XT-4000i Automated Hematology Analyzer. The nonparametric 2...
November 15, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27861919/consequences-of-maternal-omega-3-polyunsaturated-fatty-acid-supplementation-on-respiratory-function-in-rat-pups
#17
Luana Tenorio-Lopes, Cécile Baldy, Alexandra Jochmans-Lemoine, Océane Mercier, Olivier Pothier-Piccinin, Tommy Seaborn, Vincent Joseph, Isabelle Marc, Richard Kinkead
KEY POINTS: Incomplete development of the neural circuits that control breathing contributes to respiratory disorders in pre-term infants. Manifestations include respiratory instability, prolonged apnoeas and poor ventilatory responses to stimuli. Based on evidence suggesting that omega-3 polyunsaturated fatty acids (n-3 PUFA) improves brain development, we determined whether n-3 PUFA supplementation (via the maternal diet) improves respiratory function in 10-11-day-old rat pups. n-3 PUFA treatment prolonged apnoea duration but augmented the relative pulmonary surface area and the ventilatory response to hypoxia...
November 11, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27854066/cancer-recurrence-following-conversion-during-laparoscopic-colorectal-resections-a-meta-analysis
#18
REVIEW
Mariano Cesare Giglio, Gaetano Luglio, Viviana Sollazzo, Filomena Liccardo, Roberto Peltrini, Michele Sacco, Giovanni Spiezio, Bruno Amato, Giovanni Domenico De Palma, Luigi Bucci
INTRODUCTION: Evidence regarding long-term oncological outcomes following conversion to open surgery (COS) during laparoscopic colorectal resection (LCR) is controversial. The aim of this study is to assess the impact on cancer recurrence of a failed laparoscopic attempt. METHODS: MEDLINE, Scopus and ISI Web of Knowledge databases were searched for articles reporting data on cancer recurrence in patients undergoing completed LCR and COS. Data were pooled by fixed or random effect modeling, according to the presence of heterogeneity...
November 16, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27852408/-study-on-the-difference-of-blood-coagulation-function-in-patients-with-traumatic-brain-injury-in-plain-and-plateau-area
#19
J Sun, Y Tian, R C Jiang, X L Dong, Y Wang, W B Wu, K X Wu, J N Zhang
Objective: In this study, we tested platelet count (PC), prothrombin time (PT), activated partial thromboplastin time (APTT), and other indicators of coagulation function, and revealed their difference in patients with traumatic brain injury (TBI) between plain and plateau area. Base on the results, we may provide research basis for the therapy of TBI associated coagulopathy in different areas. Methods: 151 TBI patients from Tianjin Medical University General Hospital, and 74 from People's Hospital of Tibet Autonomous Region in the period from Dec 2013 to Dec 2015 were enrolled...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27836119/a-multi-institutional-analysis-of-prospective-studies-of-carbon-ion-radiotherapy-for-prostate-cancer-a-report-from-the-japan-carbon-ion-radiation-oncology-study-group-j-cros
#20
Takuma Nomiya, Hiroshi Tsuji, Hidemasa Kawamura, Tatsuya Ohno, Shingo Toyama, Yoshiyuki Shioyama, Yuko Nakayama, Kenji Nemoto, Hirohiko Tsujii, Tadashi Kamada
BACKGROUND AND PURPOSE: A multi-institutional observational study (J-CROS1501PR) has been carried out to analyze outcomes of carbon-ion radiotherapy (CIRT) for patients with prostate cancer. PATIENTS AND METHODS: Data of the patients enrolled in prospective studies of following 3 CIRT institutions were analyzed: National Institute of Radiological Sciences (NIRS; Chiba, Japan), Gunma University Heavy Ion Medical Center (GHMC; Gunma, Japan), and Ion Beam Therapy Center, SAGA HIMAT Foundation (HIMAT; Saga, Japan)...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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