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https://www.readbyqxmd.com/read/28532400/oligometastases-from-prostate-cancer-local-treatment-with-stereotactic-body-radiotherapy-sbrt
#1
Gregor Habl, Christoph Straube, Kilian Schiller, Marciana Nona Duma, Markus Oechsner, Kerstin A Kessel, Matthias Eiber, Markus Schwaiger, Hubert Kübler, Jürgen E Gschwend, Stephanie E Combs
BACKGROUND: The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated oligometastasized PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases. METHODS: In this retrospective study, 15 oligometastasized PC patients with a total of 20 bone metastases were evaluated regarding biochemical progression-free survival (PSA-PFS), time to initiation of ADT, and local control rate (LCR)...
May 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28521481/increased-methylation-of-human-papillomavirus-type-16-dna-is-associated-with-the-severity-of-cervical-lesions-in-infected-females-from-northeast-china
#2
Wei Wang, Zhengrong Sun, Jianhua Liu, Guili Wang, Zhitao Lu, Weiqiang Zhou, Te Qi, Qiang Ruan
Hypermethylation of the cytosine-phosphate-guanine (CpG) sites located at the 3'-major capsid protein L1 (3'L1) and the long control region (LCR) of the human papillomavirus (HPV) genome may be associated with the progression of cervical cancer (CC). However, the methylation status of the LCR of HPV type 16 DNA remains to be elucidated in an infected Chinese population. The aim of the present study was to investigate the association between methylation of the HPV 16 L1 gene and LCR, and the severity of cervical lesions in infected female patients...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520978/ldb1-mediated-enhancer-looping-can-be-established-independent-of-mediator-and-cohesin
#3
Ivan Krivega, Ann Dean
Mechanistic studies in erythroid cells indicate that LDB1, as part of a GATA1/TAL1/LMO2 complex, brings erythroid-expressed genes into proximity with enhancers for transcription activation. The role of co-activators in establishing this long-range interaction is poorly understood. Here we tested the contributions of the RNA Pol II pre-initiation complex (PIC), mediator and cohesin to establishment of locus control region (LCR)/β-globin proximity. CRISPR/Cas9 editing of the β-globin promoter to eliminate the RNA Pol II PIC by deleting the TATA-box resulted in loss of transcription, but enhancer-promoter interaction was unaffected...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28504310/aerobic-capacity-mediates-susceptibility-for-the-transition-from-steatosis-to-steatohepatitis
#4
E Matthew Morris, Colin S McCoin, Julie A Allen, Michelle L Gastecki, Lauren G Koch, Steven L Britton, Justin A Fletcher, Xiarong Fu, Wen-Xing Ding, Shawn C Burgess, R Scott Rector, John P Thyfault
BACKGROUND & AIMS: Low aerobic capacity increases risk for NAFLD and liver-related disease mortality, but mechanisms mediating these effects remain unknown. We recently reported that rats bred for low aerobic capacity (low capacity runner (LCR)) displayed susceptibility to high-fat diet-induced steatosis in association with reduced hepatic mitochondrial fatty acid oxidation (FAO) and respiratory capacity compared to high aerobic capacity (high capacity runners (HCR)) rats. Here we tested the impact of aerobic capacity on susceptibility for progressive liver disease following a 16 week 'western diet' high in fat (45% kcal), cholesterol (1% w w(-1) ), and sucrose (15% kcal)...
May 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28479691/prevalence-of-human-papillomavirus16-dna-and-p16-ink4a-protein-in-oral-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#5
T Smitha, C V Mohan, S Hemavathy
BACKGROUND AND AIM: Indian patients with oral squamous cell carcinoma (OSCC) are etiologically associated with the use of tobacco and alcohol; yet, a proportion of tumors that may harbor human papillomavirus (HPV) infections cannot be neglected. The following meta-analysis was conducted to address the association of p16(INK4a) and HPV DNA with OSCC. In addition, the study also provides the updated prevalence of HPV-induced OSCC. MATERIALS AND METHODS: Literature survey was performed using databases such as PubMed with the help of the following keywords - "HPV infection," "oral squamous cell carcinoma," "p16(INK4a)," "HPV DNA," "E6," "E7," "L1," "L2" and "LCR...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28473706/molecular-mechanisms-underlying-the-evolution-of-the-slp76-signalosome
#6
Xuemei Qu, Xin Lan, Chong Deng, Jiatao Zhou, Jingjing Du, Shengfeng Huang, Yingqiu Li
The well-defined mammalian slp76-signalosome is crucial for T-cell immune response, yet whether slp76-signalosome exists in invertebrates and how it evolved remain unknown. Here we investigated slp76-signalosome from an evolutionary perspective in amphioxus Branchiostoma belcheri (bb). We proved slp76-signalosome components bbslp76, bbGADS and bbItk are present in amphioxus and bbslp76 interacts with bbGADS and bbItk, but differences exist between the interaction manners within slp76-signalosome components of amphioxus and human (h)...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470327/relationship-between-coronary-tortuosity-and-plateletcrit-coronary-tortuosity-and-plateletcrit
#7
Levent Cerit, Zeynep Cerit
BACKGROUND: Coronary tortuosity (CorT) is a common angiographic finding and may be associated with myocardial ischaemia, even without coronary artery disease. Platelets play a crucial role in inflammatory and thrombotic processes and the physiopathology of cardiovascular disease. Larger platelets are more active enzymatically and have higher thrombotic ability compared to smaller platelets. Plateletcrit (PCT) provides complete information on total platelet mass. We aimed to evaluate the relationship between CorT and PCT in patients with chronic stable angina...
April 26, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28465283/expression-of-micrornas-and-target-proteins-in-skeletal-muscle-of-rats-selectively-bred-for-high-and-low-running-capacity
#8
Samuel Pinto, Séverine Lamon, Erin J Stephenson, Ming Kalanon, Jasmine Mikovic, Lauren G Koch, Steven L Britton, John A Hawley, Donny M Camera
Impairments in mitochondrial function and substrate metabolism are implicated in the etiology of obesity and type 2 diabetes. MicroRNAs (miRNAs) can degrade mRNA or repress protein translation and have been implicated in the development of such disorders. We used a contrasting rat model system of selectively bred high- (HCR) or low- (LCR) intrinsic running capacity with established differences in metabolic health to investigate the molecular mechanisms through which miRNAs regulate target proteins mediating mitochondrial function and substrate oxidation processes...
May 2, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28431571/unique-lcr-variations-among-lineages-of-hpv16-18-and-45-isolates-from-women-with-normal-cervical-cytology-in-ghana
#9
Adolf K Awua, Richard M K Adanu, Edwin K Wiredu, Edwin A Afari, Vanessa A Zubuch, Richard H Asmah, Alberto Severini
BACKGROUND: In addition to being useful for classification, sequence variations of human Papillomavirus (HPV) genotypes have been implicated in differential oncogenic potential and a differential association with the different histological forms of invasive cervical cancer. These associations have also been indicated for HPV genotype lineages and sub-lineages. In order to better understand the potential implications of lineage variation in the occurrence of cervical cancers in Ghana, we studied the lineages of the three most prevalent HPV genotypes among women with normal cytology as baseline to further studies...
April 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28426749/molecular-characterization-tissue-tropism-and-genetic-variability-of-the-novel-mupapillomavirus-type-hpv204-and-phylogenetically-related-types-hpv1-and-hpv63
#10
Anja Šterbenc, Lea Hošnjak, Diego Chouhy, Elisa M Bolatti, Anja Oštrbenk, Katja Seme, Boštjan J Kocjan, Boštjan Luzar, Adriana A Giri, Mario Poljak
HPV204 is the only newly identified Mupapillomavirus (Mu-PV) type in more than a decade. To comprehensively characterize HPV204, we performed a detailed molecular analysis of the viral genome and evaluated its clinical relevance in comparison to the other Mu-PVs, HPV1 and HPV63. The 7,227-bp long genome of HPV204 exhibits typical genomic organization of Mu-PVs with eight open reading frames (ORFs) (E6, E7, E1, E2, E8, E4, L2, and L1). We developed three type-specific quantitative real-time PCRs and used them to test a representative collection (n = 1,006) of various HPV-associated benign and malignant neoplasms, as well as samples of clinically normal cutaneous, mucosal, and mucocutaneous origins...
2017: PloS One
https://www.readbyqxmd.com/read/28394617/understanding-the-impact-of-water-on-the-miscibility-and-microstructure-of-amorphous-solid-dispersions-an-afm-lcr-and-tem-edx-study
#11
Na Li, Christopher J Gilpin, Lynne S Taylor
Miscibility is critical for amorphous solid dispersions (ASDs). Phase-separated ASDs are more prone to crystallization, and thus can lose their solubility advantage leading to product failure. Additionally, dissolution performance can be diminished as a result of phase separation in the ASD matrix. Water is known to induce phase separation during storage for some ASDs. However, the impact of water introduced during preparation has not been as thoroughly investigated to date. The purpose of this study was to develop a mechanistic understanding of the effect of water on the phase behavior and microstructure of ASDs...
April 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28372251/chlorogenic-acid-anthocyanin-and-flavan-3-ol-biosynthesis-in-flesh-and-skin-of-andean-potato-tubers-solanum-tuberosum-subsp-andigena
#12
Matías Ariel Valiñas, María Luciana Lanteri, Arjen Ten Have, Adriana Balbina Andreu
Natural variation of Andean potato was used to study the biosynthesis of phenolic compounds. Levels of phenolic compounds and corresponding structural gene transcripts were examined in flesh and skin of tubers. Phenolic acids, mainly chlorogenic acid (CGA), represent the major compounds, followed by anthocyanins and flavan-3-ols. High-anthocyanin varieties have high levels of CGA. Both metabolite and transcript levels were higher in skin than in flesh and showed a good correspondence. Two hydroxycinnamoyl-CoA transferases (HCT/HQT) have been involved in CGA production, of which HCT reflects CGA levels...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28367021/platelet-volume-indices-as-predictive-biomarkers-for-diabetic-complications-in-type-2-diabetic-patients
#13
Archana Buch, Supreet Kaur, Rahul Nair, Ambuj Jain
BACKGROUND: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW), and platelet-large cell ratio (P-LCR) are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications. PURPOSE: To study PVI in Type 2 diabetics with and without complications in comparison to nondiabetic patients. MATERIALS AND METHODS: A case-control study was conducted on 300 Type 2 diabetics and 200 nondiabetics...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28334054/lateral-cephalometric-analysis-for-treatment-planning-in-orthodontics-based-on-mri-compared-with-radiographs-a-feasibility-study-in-children-and-adolescents
#14
Alexander Heil, Eduardo Lazo Gonzalez, Tim Hilgenfeld, Philipp Kickingereder, Martin Bendszus, Sabine Heiland, Ann-Kathrin Ozga, Andreas Sommer, Christopher J Lux, Sebastian Zingler
OBJECTIVE: The objective of this prospective study was to evaluate whether magnetic resonance imaging (MRI) is equivalent to lateral cephalometric radiographs (LCR, "gold standard") in cephalometric analysis. METHODS: The applied MRI technique was optimized for short scanning time, high resolution, high contrast and geometric accuracy. Prior to orthodontic treatment, 20 patients (mean age ± SD, 13.95 years ± 5.34) received MRI and LCR. MRI datasets were postprocessed into lateral cephalograms...
2017: PloS One
https://www.readbyqxmd.com/read/28326663/a-morphometric-study-of-the-canine-skull-and-periorbita-and-its-implications-for-regional-ocular-anesthesia
#15
Paulo Roberto Klaumann, Juan Carlos Duque Moreno, Fabiano Montiani-Ferreira
OBJECTIVE: A hypothetical relationship between canine cranial length and the length of the periorbita could be used for intraconal anesthetic volume estimation. STUDY SUBJECTS: Forty-one canine cadaver heads and one macerated dog skull. PROCEDURES: Inion and nasion points were recognized in the macerated skull and used as landmarks for cranial length measure. Thirty cadavers classified as dolichocephalic, mesaticephalic and brachycephalic were distributed in three study groups...
March 22, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28316224/-relief-effect-of-ct-guided-125-i-seed-implantation-on-patients-with-spinal-and-paraspinal-osteolytic-metastatic-tumors
#16
H Huang, F S Li, L Wang, Z G Du, S N Xu
Objective: To evaluate the clinical value of computed tomography (CT)-guided (125)I seed implantation in the treatment of patients with spinal and/or paraspinal osteolytic metastatic tumors. Methods: The radiation dose distribution was planned for 27 patients with 35 spinal and paraspinal osteolytic metastatic tumors by a treatment planning system (TPS). CT-guided (125)I seed implantation was carried out in the patients, and the quality of treatment was evaluated based on CT-imaging follow-up. Results: All the 27 patients underwent CT-guided (125)I seed implantation successfully...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28301268/efficacy-and-toxicity-profiles-of-two-chemoradiotherapies-for-stage-ii-laryngeal-cancer-a-comparison-between-late-course-accelerated-hyperfractionation-lcahf-and-conventional-fractionation-cf
#17
Eiichiro Okazaki, Naoki Matsushita, Mari Tashiro, Yasuhiko Shimatani, Kentaro Ishii, Masako Hosono, Masahiro Oishi, Yuichi Teranishi, Hiroyoshi Iguchi, Yukio Miki
OBJECTIVE: To evaluate the treatment results of late course accelerated hyperfractionation (LCAHF) compared with conventional fractionation (CF) for stage II laryngeal cancer. METHODS: Fifty-nine consecutive patients treated for stage II laryngeal cancer were retrospectively reviewed. Thirty-two patients underwent LCAHF, twice-daily fractions during the latter half with a total dose of 69 Gy. Twenty-seven patients received CF of 70 Gy. RESULTS: The local control rates (LCRs), overall survival (OS), and disease-specific survival (DSS) at 5 years were 80...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28283059/stress-triggered-phase-separation-is-an-adaptive-evolutionarily-tuned-response
#18
Joshua A Riback, Christopher D Katanski, Jamie L Kear-Scott, Evgeny V Pilipenko, Alexandra E Rojek, Tobin R Sosnick, D Allan Drummond
In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels, and other assemblies lacking fixed stoichiometry. Observing these phenomena has generally required conditions far removed from physiological stresses. We show that poly(A)-binding protein (Pab1 in yeast), a defining marker of stress granules, phase separates and forms hydrogels in vitro upon exposure to physiological stress conditions...
March 9, 2017: Cell
https://www.readbyqxmd.com/read/28269241/label-free-detection-of-sex-determining-region-y-sry-via-capacitive-biosensor
#19
Shilpa Sivashankar, Christos Sapsanis, Sumeyra Agambayev, Ulrich Buttner, Khaled Nabil Salama
In this work, we present for the first time, the use of a simple fractal capacitive biosensor for the quantification and detection of sex-determining region Y (SRY) genes. This section of genetic code, which is found on the Y chromosome, finds importance for study as it causes fetuses to develop characteristics of male sex-like gonads when a mutation occurs. It is also an important genetic code in men, and disorders involving the SRY gene can cause infertility and sexual malfunction that lead to a variety of gene mutational disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28245287/study-of-association-and-molecular-analysis-of-human-papillomavirus-in-breast-cancer-of-indian-patients-clinical-and-prognostic-implication
#20
Saimul Islam, Hemantika Dasgupta, Anirban Roychowdhury, Rittwika Bhattacharya, Nupur Mukherjee, Anup Roy, Gautam Kumar Mandal, Neyaz Alam, Jaydip Biswas, Shyamsundar Mandal, Susanta Roychoudhury, Chinmay Kumar Panda
OBJECTIVES: Human papillomavirus (HPV) causes tumors primarily Cervical cancer. Recently, inconsistent reports came up in Breast cancer (BC) too. In India, despite treatment 70,218 BC patients die each year. So, we explored the association of HPV, if any, with BC prognosis in Indian pre-therapeutic (PT) and Neo-adjuvant chemotherapy (NACT) patients with subsequent analysis of HPV profile. METHODS: HPV prevalence was checked and analysis of physical status, copy number, genome variation, promoter methylation and expression (mRNA and protein) of the prevalent subtype was done...
2017: PloS One
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