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https://www.readbyqxmd.com/read/28161276/erythroid-specific-activator-gata-1-dependent-interactions-between-ctcf-sites-around-the-%C3%AE-globin-locus
#1
Yujin Kang, Yea Woon Kim, Jin Kang, Won Ju Yun, AeRi Kim
CTCF sites (binding motifs for CCCTC-binding factor, an insulator protein) are located considerable distances apart on genomes but are closely positioned in organized chromatin. The close positioning of CTCF sites is often cell type or tissue specific. Here we analyzed chromatin organization in eight CTCF sites around the β-globin locus by 3C assay and explored the roles of erythroid specific transcription activator GATA-1 and KLF1 in it. It was found five CTCF sites convergent to the locus interact with each other in erythroid K562 cells but not in non-erythroid 293 cells...
February 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28141745/deferasirox-iron-complex-formation-ratio-as-an-indicator-of-long-term-chelation-efficacy-in-%C3%AE-thalassemia-major
#2
Meng-Yao Lu, Ting-Hao Lin, Po-Hung Chiang, Pei-Hsin Kuo, Ning Wang, Wen-Hsin Wu, Kai-Hsin Lin, Tzu-Hua Wu
BACKGROUND: β-Thalassemia major patients with higher total drug levels (deferasirox [DEFR] plus its iron complex) do not yield better serum ferritin (SF) control. This study aimed to determine the concentrations of DEFR and its iron complex (Fe-[DEFR]2) in thalassemia patients to predict the chelation efficacy in terms of SF and cardiac T2* values. METHODS: Patients' steady-state drug levels at trough (Ctrough) and 2 hours post-dose (C2h) were determined. Since iron deposition may cause changes in the hepatic metabolism of amino acids, the concentrations of 40 amino acids in plasma were also assayed at 2 hours post-dose...
January 30, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28028845/genome-wide-snp-data-reveal-cryptic-phylogeographic-structure-and-microallopatric-divergence-in-a-rapids-adapted-clade-of-cichlids-from-the-congo-river
#3
S Elizabeth Alter, Jason Munshi-South, Melanie L J Stiassny
The lower Congo River (LCR) is a freshwater biodiversity hotspot in Africa characterized by some of the world's largest rapids. However, little is known about the evolutionary forces shaping this diversity, which include numerous endemic fishes. We investigated phylogeographic relationships in Teleogramma, a small clade of rheophilic cichlids, in the context of regional geography and hydrology. Previous studies have been unable to resolve phylogenetic relationships within Teleogramma due to lack of variation in nuclear genes and discrete morphological characters among putative species...
December 28, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28026147/development-of-a-novel-immobilization-method-by-using-microgels-to-keep-enzyme-in-hydrated-microenvironment-in-porous-hydrophobic-membranes
#4
Giuseppe Vitola, Dominic Büning, Jens Schumacher, Rosalinda Mazzei, Lidietta Giorno, Mathias Ulbricht
Using colloidal polyacrylamide (PAAm) microgels as carriers, a novel strategy for covalent immobilization of enzymes maintained in hydrated microenvironment on/in a macroporous surface-functionalized hydrophobic polyvinylidene fluoride (PVDF) membrane is developed. The PAAm microgels are synthesized by inverse miniemulsion polymerization, and first the parameters are investigated which are suited to obtain particles in the desired size range, 100-200 nm, with narrow size distribution. Amino functions are then imparted to the microgels applying the Hofmann reaction...
December 27, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28004846/short-term-economic-impact-of-the-zika-virus-outbreak
#5
Daniele Macciocchi, Simone Lanini, Francesco Vairo, Alimuddin Zumla, Luiz Tadeu Moraes Figueiredo, Francesco Nicola Lauria, Gino Strada, Philippe Brouqui, Vincenzo Puro, Sanjeev Krishna, Peter Kremsner, Paola Scognamiglio, Carsten Köhler, Emanuele Nicastri, Antonino Di Caro, Rodolfo Maria Cieri, John P A Ioannidis, Gary Kobinger, Marcelo Nascimento Burattini, Giuseppe Ippolito
Zika virus (ZIKV) is mainly transmitted by mosquitoes bites. However, transmission by sexual contacts has been reported in 11 non endemic countries. The rapid spread of ZIKV in Latin American and Caribbean Countries (LCR), person-to-person transmission and perceived risk on people's well being can affect the emerging economies of LCR which historically dependent on truism. Here we present an analysis on economic outputs for assessing the current impact of ZIKV on markets. Our analysis show an unexpected resilience of LCR markets to international alerts...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27998803/a-pilot-study-on-hla-g-locus-control-region-haplotypes-and-cervical-intraepithelial-neoplasias
#6
Juliana Cochesnki Cordeiro, Jose Samuel da Silva, Valeria Sperandio Roxo, Maria da Graça Bicalho
Human papillomavirus (HPV) can induce cervical intraepithelial neoplasias (CIN) grades 1, 2 and 3. Untreated, these lesions may progress to cervical cancer (CC) which is the third most common cancer in women worldwide. HLA-G plays an immunotolerant role in the immune response. The aim of this study was to characterize the configuration of SNPs located at the distal promoter of HLA-G in patients with CIN2 and CIN3 and control women. The study sample was composed of 207 women as follows: 73 diagnosed with CIN2 lesions, 56 with CIN3 and 78 healthy control women...
December 17, 2016: Human Immunology
https://www.readbyqxmd.com/read/27939161/epidemiologic-analysis-of-a-sarcoid-outbreak-involving-12-of-111-donkeys-in-northern-italy
#7
Hans Abel-Reichwald, Edmund K Hainisch, Sophie Zahalka, Annunziata Corteggio, Giuseppe Borzacchiello, Barbara Massa, Luca Merlone, Lubna Nasir, Faith Burden, Sabine Brandt
Equine sarcoids develop upon bovine papillomavirus type 1 or 2 (BPV1, BPV2) infection in conjunction with trauma and represent the most common tumour disease in horses and other equids, including donkeys. In face of a sarcoid outbreak involving 12 of 111 donkeys and mules at the 'Rifugio degli Asinelli', a subsidiary charity organization of The Donkey Sanctuary, non-invasively collected sample material including crusts, dandruff, swabs and hair roots was collected from sarcoid-affected and 26 healthy donkeys, as well as dandruff from a grooming kit and tabanids caught from or in the vicinity of sarcoid patients...
November 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27936752/high-aerobic-capacity-mitigates-changes-in-the-plasma-metabolomic-profile-associated-with-aging
#8
Oluyemi S Falegan, Hans J Vogel, Dustin S Hittel, Lauren G Koch, Steven L Britton, Russ T Hepple, Jane Shearer
Advancing age is associated with declines in maximal oxygen consumption. Declines in aerobic capacity not only contribute to the aging process but also are an independent risk factor for morbidity, cardiovascular disease, and all-cause mortality. Although statistically convincing, the relationships between aerobic capacity, aging, and disease risk remain largely unresolved. To this end, we employed sensitive, system-based metabolomics approach to determine whether enhanced aerobic capacity could mitigate some of the changes seen in the plasma metabolomic profile associated with aging...
December 19, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27862350/establishment-of-complete-blood-count-reference-intervals-for-chinese-preschoolers
#9
Guo-Cheng Wang, Na Li, Cui Niu, Wei-Bo Ma, Zhu-Liang Wang, Hao Guo, Li-Hong Han
BACKGROUND: Reference intervals are critical for interpreting test results of a clinical laboratory. The aim of this study was to establish local reference intervals of complete blood count for healthy preschoolers in China. METHODS: Three thousand eight hundred and twenty-one blood specimens from children aged 4 months to 6 years were collected and analyzed. Complete blood counts were determined by Sysmex XT-4000i Automated Hematology Analyzer. The nonparametric 2...
November 15, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27861919/consequences-of-maternal-omega-3-polyunsaturated-fatty-acid-supplementation-on-respiratory-function-in-rat-pups
#10
Luana Tenorio-Lopes, Cécile Baldy, Alexandra Jochmans-Lemoine, Océane Mercier, Olivier Pothier-Piccinin, Tommy Seaborn, Vincent Joseph, Isabelle Marc, Richard Kinkead
KEY POINTS: Incomplete development of the neural circuits that control breathing contributes to respiratory disorders in pre-term infants. Manifestations include respiratory instability, prolonged apnoeas and poor ventilatory responses to stimuli. Based on evidence suggesting that omega-3 polyunsaturated fatty acids (n-3 PUFA) improves brain development, we determined whether n-3 PUFA supplementation (via the maternal diet) improves respiratory function in 10-11-day-old rat pups. n-3 PUFA treatment prolonged apnoea duration but augmented the relative pulmonary surface area and the ventilatory response to hypoxia...
November 11, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27854066/cancer-recurrence-following-conversion-during-laparoscopic-colorectal-resections-a-meta-analysis
#11
REVIEW
Mariano Cesare Giglio, Gaetano Luglio, Viviana Sollazzo, Filomena Liccardo, Roberto Peltrini, Michele Sacco, Giovanni Spiezio, Bruno Amato, Giovanni Domenico De Palma, Luigi Bucci
INTRODUCTION: Evidence regarding long-term oncological outcomes following conversion to open surgery (COS) during laparoscopic colorectal resection (LCR) is controversial. The aim of this study is to assess the impact on cancer recurrence of a failed laparoscopic attempt. METHODS: MEDLINE, Scopus and ISI Web of Knowledge databases were searched for articles reporting data on cancer recurrence in patients undergoing completed LCR and COS. Data were pooled by fixed or random effect modeling, according to the presence of heterogeneity...
November 16, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27852408/-study-on-the-difference-of-blood-coagulation-function-in-patients-with-traumatic-brain-injury-in-plain-and-plateau-area
#12
J Sun, Y Tian, R C Jiang, X L Dong, Y Wang, W B Wu, K X Wu, J N Zhang
Objective: In this study, we tested platelet count (PC), prothrombin time (PT), activated partial thromboplastin time (APTT), and other indicators of coagulation function, and revealed their difference in patients with traumatic brain injury (TBI) between plain and plateau area. Base on the results, we may provide research basis for the therapy of TBI associated coagulopathy in different areas. Methods: 151 TBI patients from Tianjin Medical University General Hospital, and 74 from People's Hospital of Tibet Autonomous Region in the period from Dec 2013 to Dec 2015 were enrolled...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27836119/a-multi-institutional-analysis-of-prospective-studies-of-carbon-ion-radiotherapy-for-prostate-cancer-a-report-from-the-japan-carbon-ion-radiation-oncology-study-group-j-cros
#13
Takuma Nomiya, Hiroshi Tsuji, Hidemasa Kawamura, Tatsuya Ohno, Shingo Toyama, Yoshiyuki Shioyama, Yuko Nakayama, Kenji Nemoto, Hirohiko Tsujii, Tadashi Kamada
BACKGROUND AND PURPOSE: A multi-institutional observational study (J-CROS1501PR) has been carried out to analyze outcomes of carbon-ion radiotherapy (CIRT) for patients with prostate cancer. PATIENTS AND METHODS: Data of the patients enrolled in prospective studies of following 3 CIRT institutions were analyzed: National Institute of Radiological Sciences (NIRS; Chiba, Japan), Gunma University Heavy Ion Medical Center (GHMC; Gunma, Japan), and Ion Beam Therapy Center, SAGA HIMAT Foundation (HIMAT; Saga, Japan)...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27797132/a-light-colored-region-of-caudal-fin-a-niche-of-melanocyte-progenitors-in-crucian-carp-cyprinus-carpio-l
#14
Yaping Huang, Yurong Luo, Jinhui Liu, Saiyu Gui, Mei Wang, Wenbin Liu, Liangyue Peng, Yamei Xiao
Melanocyte stem cells are a population of immature cells which sustain the self-renewal and replenish the differentiated melanocytes. In this research, a light-colored region (LCR) is observed at the heel of caudal fin in juvenile crucian carp. By cutting off the caudal fin, the operated caudal fin can regenerate in accordance with the original pigment pattern from the retained LCR. As markers of stem cells, Oct4 and Sox2 have been found to be highly expressed in the LCR as well as Mitfa, a label of the melanoblasts...
January 2017: Cell Biology International
https://www.readbyqxmd.com/read/27791821/risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-river-nile-up-and-downstream-of-a-densely-populated-area
#15
Wael Abdel-Moneim Omar, Hamada M Mahmoud
A biomonitoring study was conducted to evaluate levels of eleven polycyclic aromatic hydrocarbons (PAHs) in water, sediment and wild Nile tilapia (Oreochromis niloticus) samples collected up- and downstream of Cairo sector of the River Nile, Egypt. The scaled mass index (SMI), as a fish body mass-length relationship, performed better in indicating the ecosystem and fish conditions. The total PAHs in water samples had a range of 0.0156-0.0269 mg/L, while that in sediment samples ranged from 0.723 to 1.078 mg/kg dry weight and that in fish muscles ranged from 4...
January 28, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27761714/advantages-of-laparoscopic-compared-to-conventional-surgery-are-not-related-to-an-innate-immune-response-of-peritoneal-immune-activation-an-animal-study-in-rats
#16
Philipp Lingohr, Jonas Dohmen, Hanno Matthaei, Timo Schwandt, Kathy Stein, Gun-Soo Hong, Julia Steitz, Thomas Longerich, Edwin Bölke, Sven Wehner, Jörg C Kalff
PURPOSE: Laparoscopic surgery (LS) has proved superior compared to conventional surgery (CS) regarding morbidity, length of hospital stay, rate of wound infection and time until recovery. An improved preservation of the postoperative immune function is assumed to contribute to these benefits though the role of the local peritoneal immune response is still poorly understood. Our study investigates the peritoneal immune response subsequent to abdominal surgery and compares it between laparoscopic and conventional surgery to find an immunological explanation for the clinically proven benefits of LS...
October 19, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27718511/oral-probiotic-treatment-of-lactobacillus-rhamnosus-lcr35-%C3%A2-prevents-visceral-hypersensitivity-to-a-colonic-inflammation-and-an-acute-psychological-stress
#17
Y Darbaky, B Evrard, S Patrier, J Falenta, S Garcin, A Tridon, M Dapoigny, C Silberberg, A Nivoliez, L Diop
AIMS: This study evaluated the efficacy of a repeated oral treatment with two active pharmaceutical ingredients (Lcr Lenio(®) and Lcr Restituo(®) ) derivated from the probiotic bacterial strain Lactobacillus rhamnosus Lcr35(®) in two animal models mimicking different features of irritable bowel syndrome (IBS). IBS is characterized by visceral pain associated with alteration of bowel transit. IBS patients present visceral hypersensitivity with peripheral and central origins. METHODS AND RESULTS: The injection of 2,4,6-trinitrobenzenesulfonic acid (TNBS) into the proximal colon as well as an acute partial restraint stress (PRS) produces colonic hypersensitivity measured in conscious rats by a decrease in pain threshold in response to distal colonic distension...
January 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27705914/extrachromosomal-hpv-16-lcr-transcriptional-activation-by-hdaci-opposed-by-cellular-differentiation-and-dna-integration
#18
Ekaterina Dimitrova Bojilova, Christine Weyn, Marie-Hélène Antoine, Véronique Fontaine
Histone deacetylase inhibitors (HDACi) have been shown to render HPV-carrying cells susceptible to intrinsic and extrinsic apoptotic signals. As such, these epigenetic drugs have entered clinical trials in the effort to treat cervical cancer. Here, we studied the effect of common HDACi, with an emphasis on Trichostatin A (TSA), on the transcriptional activity of the HPV-16 Long Control Region (LCR) in order to better understand the impact of these agents in the context of the HPV life cycle and infection. HDACi strongly induced transcription of the firefly luciferase reporter gene under the control of the HPV-16 LCR in a variety of cell lines...
September 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27671935/rapid-assembly-of-dna-via-ligase-cycling-reaction-lcr
#19
Sunil Chandran
The assembly of multiple DNA parts into a larger DNA construct is a requirement in most synthetic biology laboratories. Here we describe a method for the efficient, high-throughput, assembly of DNA utilizing the ligase chain reaction (LCR). The LCR method utilizes non-overlapping DNA parts that are ligated together with the guidance of bridging oligos. Using this method, we have successfully assembled up to 20 DNA parts in a single reaction or DNA constructs up to 26 kb in size.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27669449/voluntary-running-attenuates-metabolic-dysfunction-in-ovariectomized-low-fit-rats
#20
Young-Min Park, Jaume Padilla, Jill A Kanaley, Terese M Zidon, Rebecca J Welly, Steven L Britton, Lauren G Koch, John P Thyfault, Frank W Booth, Victoria J Vieira-Potter
INTRODUCTION: Ovariectomy and high-fat diet (HFD) worsen obesity and metabolic dysfunction associated with low aerobic fitness. Exercise training mitigates metabolic abnormalities induced by low aerobic fitness, but whether the protective effect is maintained after ovariectomy and HFD is unknown. PURPOSE: This study determined whether, after ovariectomy and HFD, exercise training improves metabolic function in rats bred for low intrinsic aerobic capacity. METHODS: Female rats selectively bred for low (LCR) and high (HCR) intrinsic aerobic capacity (n = 30) were ovariectomized, fed HFD, and randomized to either a sedentary (SED) or voluntary wheel running (EX) group...
February 2017: Medicine and Science in Sports and Exercise
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