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https://www.readbyqxmd.com/read/29355777/redetection-of-human-papillomavirus-type-16-infections-of-the-cervix-in-mid-adult-life
#1
Aaron Ermel, Marcia L Shew, Teresa M Imburgia, Matt Brown, Brahim Qadadri, Yan Tong, Darron R Brown
PURPOSE: To assess whether HPV 16 originally detected in adolescent women can be redetected in adulthood. METHODS: A convenience sample of 27 adult women with known HPV 16 detection during adolescence was assessed for HPV 16 redetection. A comparison of the long control region (LCR) DNA sequences was performed on some of the original and redetected HPV 16 isolates. RESULTS: Median age at reenrollment was 27.5 years (interquartile range of 26...
January 16, 2018: Papillomavirus Research
https://www.readbyqxmd.com/read/29352518/ropivacaine-preperitoneal-wound-infusion-for-pain-relief-and-prevention-of-incisional-hyperalgesia-after-laparoscopic-colorectal-surgery
#2
M Beaussier, Y Parc, J Guechot, M Cachanado, A Rousseau, T Lescot
AIM: The abdominal incision for specimen extraction could trigger postoperative pain after laparoscopic colorectal resections (LCR). Continuous Wound Infusion (CWI) of ropivacaine may be a valuable option for postoperative analgesia. This study was undertaken to evaluate the potential benefits of ropivacaine CWI on pain relief, metabolic stress reaction, prevention of wound hyperalgesia and residual incisional pain after LCR. A subgroup with intravenous lidocaine infusion (IVL) was added to discriminate between the peripheral and systemic effects of local anaesthetic infusions...
January 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29335076/-value-of-arterial-blood-lactic-acid-in-the-evaluation-of-disease-severity-and-prognosis-in-neonatal-shock
#3
Wen-Hao Yuan, Ling-Kong Zeng, Bao-Huan Cai, Xiao-Yan Liu, Shi Wang, Ling-Xia Zhao, Yan-Ping Huang, Qiao-Ling Wang, Han-Chu Liu
OBJECTIVE: To evaluate the value of blood lactic acid (BLA) as a predictor for the severity and prognosis of neonatal shock. METHODS: A total of 326 neonates with shock were enrolled and divided into three groups based on the severity, namely mild group (n=147), moderate group (n=105), and severe group (n=74). BLA level was measured during and early after (about 6 hours later) fluid resuscitation, and lactate clearance rate (LCR) was calculated. The receiver operating characteristic (ROC) curve was applied to evaluate the predictive value of BLA in neonatal shock...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29321589/comparative-analysis-of-low-complexity-regions-in-plasmodia
#4
S R Chaudhry, N Lwin, D Phelan, A A Escalante, F U Battistuzzi
Low complexity regions (LCRs) are a common feature shared by many genomes, but their evolutionary and functional significance remains mostly unknown. At the core of the uncertainty is a poor understanding of the mechanisms that regulate their retention in genomes, whether driven by natural selection or neutral evolution. Applying a comparative approach of LCRs to multiple strains and species is a powerful approach to identify patterns of conservation in these regions. Using this method, we investigate the evolutionary history of LCRs in the genus Plasmodium based on orthologous protein coding genes shared by 11 species and strains from primate and rodent-infecting pathogens...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29296613/mglur2-3-activation-of-the-sirt1-axis-preserves-mitochondrial-function-in-diabetic-neuropathy
#5
Krish Chandrasekaran, Anjaneyulu Muragundla, Tyler G Demarest, Joungil Choi, Avinash R Sagi, Neda Najimi, Pranith Kumar, Anmol Singh, Cheng-Ying Ho, Gary Fiskum, Lauren G Koch, Steven L Britton, James W Russell
Objectives: There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function. Methods: Adult male streptozotocin treated Sprague-Dawley rats with features of type 1 diabetes mellitus (T1DM) or Low Capacity Running (LCR) rats with insulin resistance or glucose intolerance were treated with 3 or 10 mg/kg/day LY379268...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29287135/pulmonary-hypoplasia-in-fetuses-with-congenital-conotruncal-defects
#6
Qian Wang, Ying Zhao, Ling Han, Ye Zhang, Shuping Ge, Yihua He
OBJECTIVES: We sought to investigate pulmonary hypoplasia (PH) and associated risk factors in fetuses with congenital conotruncal defect (CTD). METHODS: A total of 75 fetuses with CTD (gestational age (GA): 22-32 weeks) and 150 normal GA-matched fetuses as the control group were studied. We measured diameters of aorta (Ao); main, left, and right pulmonary artery (PA); and their Z-scores by fetal echocardiography (FE). We also measured the lung area, lung area/chest area ratio (LCR), lung-to-head circumference ratio (LHR), right lung area/head circumference2 (quantitative lung index, QLI), and Z-scores...
December 2017: Echocardiography
https://www.readbyqxmd.com/read/29280456/magnetic-resonance-image-guided-adaptive-brachytherapy-in-locally-advanced-cervical-cancer-an-experience-from-a-tertiary-cancer-center-in-a-low-and-middle-income-countries-setting
#7
Umesh Mahantshetty, Rahul Krishnatry, Vinod Hande, Swamidas Jamema, Yogesh Ghadi, Reena Engineer, Supriya Chopra, Lavanya Gurram, Deepak Deshpande, Shyamkishore Shrviastava
PURPOSE: To determine the clinical impact of magnetic resonance image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) (stages II and III) in a tertiary care cancer hospital in a low and middle income countries setting. METHODS AND MATERIALS: Ninety-four LACC patients enrolled in a prospective EMBRACE (An International Study on MRI-Guided Brachytherapy in Locally Advanced Cervical Cancer) protocol treated with external radiation therapy (45 Gy in 25 fractions) with or without weekly cisplatin, followed by magnetic resonance IGABT (4 fractions of 7 Gy), were analyzed in detail for dosimetric and clinical outcomes including late toxicities...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29226756/voluntary-wheel-running-improves-adipose-tissue-immunometabolism-in-ovariectomized-low-fit-rats
#8
Terese M Zidon, Young-Min Park, Rebecca J Welly, Makenzie L Woodford, Rebecca J Scroggins, Steven L Britton, Lauren G Koch, Frank W Booth, Jaume Padilla, Jill A Kanaley, Victoria J Vieira-Potter
Loss of ovarian hormones is associated with increased adiposity, white adipose tissue (WAT) inflammation, and insulin resistance (IR). Previous work demonstrated ovariectomized (OVX) rats bred for high aerobic fitness (HCR) are protected against weight gain and IR compared to rats bred for low aerobic fitness (LCR) yet wheel running prevents OVX-induced IR in LCR rats. The purpose of this study was to determine whether adipose tissue immunometabolic characteristics from female HCR and LCR rats differs before or after OVX, and whether wheel running mitigates OVX-induced adipose tissue immunometabolic changes in LCR rats...
December 11, 2017: Adipocyte
https://www.readbyqxmd.com/read/29225649/incidence-of-dentinal-defects-and-vertical-root-fractures-after-endodontic-retreatment-and-mechanical-cycling
#9
Mariana De Carlo Bello, Rafael Pillar, Pauline Mastella Lang, Carina Michelon, Ricardo Abreu da Rosa, Carlos Alexandre Souza Bier
Introduction: The aim of this study was to evaluate the incidence of dentinal defects and vertical root fractures (VRFs) after endodontic retreatment and mechanical cycling (MC). Methods and Materials: Two hundred mandibular premolars were selected. Forty teeth were left unprepared (control group). The remaining 160 root canals were prepared with ProTaper instruments and filled by using two different techniques [eighty with lateral compaction (LC) and eighty with single-cone (SC)]...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29212188/baseline-platelet-parameters-for-predicting-early-platelet-response-and-clinical-outcomes-in-patients-with-non-cardioembolic-ischemic-stroke-treated-with-clopidogrel
#10
Wenxian Li, Xiaomei Xie, Di Wei, Shijun Zhang, Yuanling Wu, Xuejun Fu, Zhen Jing, Weibiao Lu, Xinqiang Lai, Li'an Huang
Purpose: The present study investigated whether routine baseline platelet parameters(BPPs) detected before clopidogrel therapy in acute non-cardioembolic ischemic stroke(NCIS) could predict early platelet response and future clinical outcomes. Results: The CYP2C19 polymorphisms constituted independent risk factors for LCR. The number of female patients, the incidence of diabetes mellitus (DM), the level of low-density lipoprotein(LDL) cholesterol, and the neutrophil-to-lymphocyte ratio(NLR) were significantly high in the clinical clopidogrel resistance (CCR) group...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29193955/polymeric-nanoparticle-coated-pickering-emulsion-synthesized-conducting-polyaniline-hybrid-particles-and-their-electrorheological-study
#11
Chan Soo Jun, Seung Hyuk Kwon, Hyoung Jin Choi, Yongsok Seo
To produce an electric stimuli-responsive electrorheological (ER) material, semi-conducting core/shell typed polyaniline (PANI) hybrid particles were fabricated through Pickering emulsion-type polymerization, using poly(divinylbenzene-alt-maleic anhydride) (PDVMA) particles as a solid surfactant. The PDVMA nanoparticles were initially polymerized using a self-stable precipitation method. The fabricated PANI/PDVMA composite particles were subjected to various chemical characterizations; further, they were suspended in silicone oil at 10 vol% to prepare an ER fluid, and their viscoelastic behaviors were scrutinized using a rheometer under various input electric fields...
December 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29147671/distal-22q11-2-microduplication-case-report-and-review-of-the-literature
#12
Elana Pinchefsky, Laurence Laneuville, Myriam Srour
Distal chromosome 22q11.2 microduplications are associated with a wide range of phenotypes and unclear pathogenicity. The authors report on a 3-year-old girl with global developmental delay harboring a de novo 1.24 Mb distal chromosome 22q11.2 microduplication and a paternally inherited 0.25 Mb chromosome 4p14 microduplication. The authors review clinical features of 30 reported cases of distal 22q11.2 duplications. Common features include developmental delay (93%), neuropsychiatric features (26%), and nonspecific facial dysmorphisms (74%)...
January 2017: Child Neurology Open
https://www.readbyqxmd.com/read/29145053/elucidating-the-urban-levels-sources-and-health-risks-of-polycyclic-aromatic-hydrocarbons-pahs-in-pakistan-implications-for-changing-energy-demand
#13
Naima Hamid, Jabir Hussain Syed, Muhammad Junaid, Adeel Mahmood, Jun Li, Gan Zhang, Riffat Naseem Malik
Due to the severe fuel crisis in terms of natural gas, a paradigm shift in fuel combustion (diesel, gasoline, and biomass) may increase the atmospheric emissions and associated health risks in Pakistan. Present study was aimed to investigate the concentration of fugitive PAHs in the environment (outdoor and indoor settings), associated probabilistic health risk assessment in the exposed population, and possible linkage between fuel consumption patterns and PAHs emissions in twin cities (Rawalpindi and Islamabad) of Pakistan...
November 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29113823/genomic-comparison-of-bovine-papillomavirus-1-isolates-from-bovine-equine-and-asinine-lesional-tissue-samples
#14
C Koch, A S Ramsauer, M Drögemüller, M Ackermann, V Gerber, K Tobler
Several attempts have been made to categorize equid- and bovid-specific bovine papillomavirus 1 (BPV1) isolates based on sequence tags. This study includes newly determined sequence information from 33 BPV1 isolates of equine, asinine and bovine origin and investigates sequence bias due to host species. Twenty of the viral genomes were sequenced over their entire length and a further thirteen were sequenced, including flanking sequences, at two specific sites, the LCR and the E5 ORF. Alignment and analyses of the sequences did not reveal statistically significant site differences between the sequences of bovine and equid origin...
November 4, 2017: Virus Research
https://www.readbyqxmd.com/read/29090080/critical-region-within-22q11-2-linked-to-higher-rate-of-autism-spectrum-disorder
#15
Caitlin C Clements, Tara L Wenger, Alisa R Zoltowski, Jennifer R Bertollo, Judith S Miller, Ashley B de Marchena, Lauren M Mitteer, John C Carey, Benjamin E Yerys, Elaine H Zackai, Beverly S Emanuel, Donna M McDonald-McGinn, Robert T Schultz
BACKGROUND: Previous studies have reported no clear critical region for medical comorbidities in children with deletions or duplications of 22q11.2. The purpose of this study was to evaluate whether individuals with small nested deletions or duplications of the LCR-A to B region of 22q11.2 show an elevated rate of autism spectrum disorder (ASD) compared to individuals with deletions or duplications that do not include this region. METHODS: We recruited 46 patients with nested deletions (n = 33) or duplications (n = 13) of 22q11...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29089142/survival-in-patients-with-parotid-gland-carcinoma-results-of-a-multi-center-study
#16
Keigo Honda, Shinzo Tanaka, Shogo Shinohara, Ryo Asato, Hisanobu Tamaki, Toshiki Maetani, Ichiro Tateya, Morimasa Kitamura, Shinji Takebayashi, Kazuyuki Ichimaru, Yoshiharu Kitani, Yohei Kumabe, Tsuyoshi Kojima, Koji Ushiro, Masanobu Mizuta, Koichiro Yamada, Koichi Omori
BACKGROUND: Parotid gland carcinoma is a rare malignancy, comprising only 1-4% of head and neck carcinomas; therefore, it is difficult for a single institution to perform meaningful analysis on its clinical characteristics. The aim of this study was to update the clinical knowledge of this rare disease by a multi-center approach. METHODS: The study was conducted by the Kyoto University Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group (Kyoto-HNOG)...
October 24, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29089135/human-cancer-risk-estimation-for-1-3-butadiene-an-assessment-of-personal-exposure-and-different-microenvironments
#17
Lai Nguyen Huy, Shun Cheng Lee, Zhuozhi Zhang
This study estimated the lifetime cancer risk (LCR) attributable to 1,3-butadiene (BD) personal exposure and to other microenvironments, including residential home, outdoor, in-office, in-vehicle, and dining. Detailed life expectancy by country (WHO), inhalation rate and body weight by gender reported by USEPA were used for the calculation, focusing on adult population (25≤Age<65). LCR estimation of the adult population due to personal exposure exceeded the USEPA benchmark of 1×10(-6) in many cities. For outdoor BD exposure, LCR estimations in 45 out of 175 cities/sites (sharing 26%) exceeded the USEPA benchmark...
October 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29075557/rats-bred-for-low-and-high-running-capacity-display-alterations-in-peripheral-tissues-and-nerves-relevant-to-neuropathy-and-pain
#18
Michael A Cooper, Megan M Jack, Janelle M Ryals, Page Hayley, Taylor Escher, Lauren G Koch, Steven L Britton, Shelby M Raupp, Michelle K Winter, Kenneth E McCarson, Paige C Geiger, John P Thyfault, Douglas E Wright
INTRODUCTION: Diet and activity are recognized as modulators of nervous system disease, including pain. Studies of exercise consistently reveal a benefit on pain. This study focused on female rats to understand differences related to metabolic status and peripheral nerve function in females. METHODS: Here, we investigated parameters of peripheral nerve function relevant to pain in rats selectively bred for high (high-capacity runners; HCR) or low endurance exercise capacity (low-capacity runners; LCR) resulting in divergent intrinsic aerobic capacities and susceptibility for metabolic conditions...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29042006/comparative-study-of-cephalometric-measurements-using-3-imaging-modalities
#19
Juan Wen, Shu Liu, Xiao Ye, Xiaoqiu Xie, Jialing Li, Huang Li, Li Mei
BACKGROUND: The authors conducted a study to compare 2-dimensional (2D) lateral cephalometric radiography (LCR), 2D cone-beam computer tomographic (CBCT)-generated cephalogram and 3-dimensional (3D) CBCT for assessing cephalometric measurements. METHODS: The authors took 2D LCR, 2D CBCT-generated cephalogram, and 3D CBCT images involving 60 participants. They obtained 11 angular and 11 linear measurements for all images. They used 1-way analysis of variance and the Fisher least significant difference test for statistical comparisons...
December 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29031407/biomass-burning-particles-in-the-brazilian-amazon-region-mutagenic-effects-of-nitro-and-oxy-pahs-and-assessment-of-health-risks
#20
Marcos Felipe de Oliveira Galvão, Nilmara de Oliveira Alves, Paula Anastácia Ferreira, Sofia Caumo, Pérola de Castro Vasconcellos, Paulo Artaxo, Sandra de Souza Hacon, Deborah Arnsdorff Roubicek, Silvia Regina Batistuzzo de Medeiros
Emissions from burning of biomass in the Amazon region have adverse effects on the environment and human health. Herein, particulate matter (PM) emitted from biomass burning in the Amazon region during two different periods, namely intense and moderate, was investigated. This study focused on: i) organic characterization of nitro- and oxy-polycyclic aromatic hydrocarbons (PAHs); ii) assessment of the excess lifetime cancer risk (LCR); and iii) assessment of the in vitro mutagenic effects of extractable organic matter (EOM)...
October 11, 2017: Environmental Pollution
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