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Mary M Mitchell, Eric D Hansen, Tuo-Yen Tseng, Meng Shen, Cynda Rushton, Tom Smith, Nancy Hutton, Jennifer Wolfe, Lee Bone, Jeanne Keruly, Lawrence Wissow, Amy R Knowlton
CONTEXT & OBJECTIVE: Advance care planning (ACP) rates remain low, especially among people who are HIV positive, disadvantaged, and African American. While ACP can be a sensitive topic for clinicians and patients to discuss, health values clarification can be an important initial step. METHODS: Data were from the first 325 participants in the AFFIRM Care study, which enrolled adults living with HIV/AIDS in Baltimore, MD, who had histories of illicit drug use...
March 8, 2018: Journal of Pain and Symptom Management
Li Gan, Delin Ma, Min Li, Fu-Chen Yang, Robert S Rogers, Joshua L Wheatley, Lauren G Koch, Steven L Britton, John P Thyfault, Paige C Geiger, John A Stanford
Aerobic capacity is a strong predictor of mortality. Low capacity runner (LCR) rats exhibit reduced mitochondrial function in peripheral organs. A high fat diet (HFD) can worsen metabolic phenotype in LCR rats. Little is known about metabolic changes in the brains of these rats, however. This study examined protein markers of mitochondrial function and metabolism as a function of aerobic running capacity and an acute HFD in four brain regions: the striatum, hippocampus, hypothalamus, and substantia nigra. After 3 days HFD or chow diets, we measured peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1-α), nuclear respiratory factors 1 (Nrf-1), mitochondrial transcription factor A (TFAM), and phosphorylated (activated) AMP-activated protein kinase (p-AMPK) protein levels in the four brain regions...
March 6, 2018: Neuroscience Letters
Fırat Dogan, Selvi Deniz Dorttas, Seval Bilge Dagalp, Veysel Soydal Ataseven, Feray Alkan
Papillomaviruses (PVs) are epitheliotropic viruses that cause benign proliferative lesions in the skin (warts or papillomas) and mucous membranes of their natural hosts. Recently, new PVs have been found in many animal species. The most common current approach for identifying novel PV types is based on PCR, using various consensus or degenerated primer (broad-range primers), designed on the basis of the multiple alignment of nucleotide or amino acid sequences of a large number of different human papillomaviruses (HPV)...
March 3, 2018: Archives of Virology
Sean M Bugel, Robert L Tanguay
The comparative analysis of complex behavioral phenotypes is valuable as a reductionist tool for both drug discovery and defining chemical bioactivity. Flavonoids are a diverse class of chemicals that elicit robust neuroactive and hormonal actions, though bioactivity information is limited for many, particularly for neurobehavioral endpoints. Here, we used a zebrafish larval chemomotor response (LCR) bioassay to comparatively evaluate a suite of 24 flavonoids, and in addition a panel of 30 model neuroactive compounds representing diverse modes of action (e...
February 27, 2018: Toxicology and Applied Pharmacology
X H Gao, P J Li, W Cao
Objective: To investigate the prognostic significance of central venous-arterial carbon dioxide tension to arterial-venous oxygen content ratio (Pcv-aCO(2)/Ca-cvO(2)) combined with lactate clearance rate (LCR) as early resuscitation goals of septic shock. Methods: One hundred and forty-five septic shock patients admitted to Second Department of Critical Care Medicine of Lanzhou University Second Hospital from March 2013 to May 2017 were enrolled in this study.All septic shock patients received an initial resuscitation therapy according to early goal-directed therapy...
February 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Camila Salata, Mariano Gazineu David, Carlos Eduardo de Almeida, Islam El Gamal, Claudiu Cojocaru, Ernesto Mainegra-Hing, Malcolm R McEwen
Two Fricke-based absorbed dose to water standards for HDR Ir-192 dosimetry, developed independently by the LCR in Brazil and the NRC in Canada have been compared. The agreement in the determination of the dose rate from a HDR Ir-192 source at 1 cm in a water phantom was found to be within the k=1 combined measurement uncertainties of the two standards: D<sub>NRC</sub>/D<sub>LCR</sub> = 1.011, standard uncertainty = 2.2 %. The dose-based standards also agreed within the uncertainties with the manufacturer's stated dose rate value, which is traceable to a national standard of air kerma...
February 28, 2018: Physics in Medicine and Biology
Michael A Moxley, Kalyan C Vinnakota, Jason N Bazil, Nathan R Qi, Daniel A Beard
High capacity and low capacity running rats, HCR and LCR respectively, have been bred to represent two extremes of running endurance and have recently demonstrated disparities in fuel usage during transient aerobic exercise. HCR rats can maintain fatty acid (FA) utilization throughout the course of transient aerobic exercise whereas LCR rats rely predominantly on glucose utilization. We hypothesized that the difference between HCR and LCR fuel utilization could be explained by a difference in mitochondrial density...
February 23, 2018: PLoS Computational Biology
Mónica Cerezales, Alain A Ocampo-Sosa, Laura Álvarez Montes, Catalina Díaz Ríos, Zulema Bustamante, Jazmín Santos, Luis Martínez-Martínez, Paul G Higgins, Lucía Gallego
Acinetobacter baumannii causes serious hospital-acquired infections and has been positioned as a priority organism by the World Health Organization. This study includes 36 A. baumannii isolates from a children hospital recovered between March 2014 and May 2015 in Cochabamba. The majority of the isolates were recovered from blood cultures (n=10, 31.3%) and respiratory samples (n=11, 34.4%); fifty three percent of the patients were younger than one month old. Most of these isolates (n=30, 80.6%) were extremely-drug resistant (XDR) and 8...
February 22, 2018: Pediatric Infectious Disease Journal
Viviana Ramas, Santiago Mirazo, Sylvia Bonilla, Dora Ruchansky, Juan Arbiza
OBJECTIVE: This study aims to investigate the HPV16 variant distribution by sequence analyses of E6, E7 oncogenes and the Long Control Region (LCR), from cervical cells collected from Uruguayan women, and to reconstruct the phylogenetic relationships among variants. METHODS: Forty-seven HPV16 variants, obtained from women with HSIL, LSIL, ASCUS and NILM cytological classes were analyzed for LCR and 12 were further studied for E6 and E7. Detailed sequence comparison, genetic heterogeneity analyses and phylogenetic reconstruction were performed...
February 14, 2018: Gene
Sung-Yong Chun
Niobium nitride (NbN) films were deposited using asymmetric-bipolar pulsed dc sputtering at different pulse parameters. Microstructural, electrical and mechanical characterizations were performed by FE-SEM, AFM, LCR meter and nanoindentator. The results show that pulse frequency has significant effects on coating's microstructure, structural and electrical properties of NbN films. With an increase in pulse frequency, coating microstructure evolved from a porous columnar structure to a highly dense one. Average crystal grain sizes of NbN films were decreased from 52...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
Dan Zheng, Hua-Ping Mou, Peng Diao, Xiao-Ming Li, Chuan-Li Zhang, Jing Jiang, Jia-Lian Chen, Li-Shuai Wang, Qiu Wang, Guang-Yuan Zhou, Jie Chen, Chuan Lin, Zhi-Ping Yuan
Objectives: To retrospectively assess the influence of radical surgery following concurrent chemoradiotherapy (CCRT) on outcomes in cervical cancer (CC) patients. Methods: Patients diagnosed with cervical squamous cell carcinoma or adenocarcinoma (FIGO stages IB2 to IIB) at the Yinbin Second People's Hospital between September 2008 and September 2013, were included in this study. Patients were classified into 2 groups based on the treatment received: surgery group (CCRT plus radical surgery) and non-surgery groups (CCRT only)...
January 5, 2018: Oncotarget
Rachita Sarangi, Sarita Pradhan, Avantika Dhanawat, Rashmi Patanayak, Gautam Benia
BACKGROUND AND OBJECTIVE: Thrombocytosis is not an uncommon finding in hemograms of children with an incidence of 6%-15% among hospitalized children. This study aims to determine the etiology of thrombocytosis and analyze various platelet parameters in children attending our hospital. MATERIALS AND METHODS: A prospective observational study was carried out in a tertiary care center in Odisha, in eastern part of India, for 6 months from July 2016 to December 2016...
January 2018: Journal of Laboratory Physicians
Kumari Shilpi, R M Potekar
Altered platelets have been reported in patients with diabetes mellitus and has been considered as a 'prothrombotic state' with enhanced platelet reactivity. They have been associated with increased risk of vascular complications in these patients. Platelet indices correlate with functional status of platelets and is an emerging risk factor of vascular complications in diabetes. The study was undertaken to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus. A prospective hospital based study of platelet parameters MPV, PDW and P-LCR was carried out on 280 cases diagnosed with Type 2 diabetes Mellitus and 280 controls with normal blood glucose levels...
January 2018: Indian Journal of Hematology & Blood Transfusion
Debasish Kumar Ghosh, Ajit Roy, Akash Ranjan
Protein misfolding due to mutation(s) and/or generation of unstable intermediate state(s) can be the cause of aberrant aggregations, leading to cellular degeneration. While molecular signatures like amyloidogenic regions cause aggregation, other features in proteins, like disorder and unique complexity regions, regulate and restrict such adhesive accumulation processes. Huntingtin interacting protein K (HYPK) is an aggregation-prone protein. Using various biophysical, microscopy and computational techniques, we have deciphered how HYPK's N-terminal nano-disordered region plays a significant modulatory role in preventing its own and other protein's aggregation...
January 30, 2018: Biochemistry
Jorge Esteban Colman Lerner, Maria de Los Angeles Gutierrez, Daniela Mellado, Daniela Giuliani, Laura Massolo, Erica Yanina Sanchez, Andres Porta
Three areas are highlighted in Gran La Plata, Argentina: industrial, urban, and residential. In this work, the levels of volatile organic compounds (VOCs) in indoor air of homes and schools in those areas were analyzed, through the use of passive monitors. The study period is between 2007 and 2010. Higher levels of VOCs were found in homes and schools in the industrial zone, higher than the levels corresponding to urban and residential. Taking into account the relationship between indoor and outdoor levels of VOCs, they have ratios (I/O) between 1...
January 29, 2018: Environmental Science and Pollution Research International
(no author information available yet)
Radiomics is one such "big data" approach that applies advanced image refining/data characterization algorithms to generate imaging features that can quantitatively classify tumor phenotypes in a non-invasive manner. We hypothesize that certain textural features of oropharyngeal cancer (OPC) primary tumors will have statistically significant correlations to patient outcomes such as local control. Patients from an IRB-approved database dispositioned to (chemo)radiotherapy for locally advanced OPC were included in this retrospective series...
January 24, 2018: Scientific Reports
Tingwei Guo, Alexander Diacou, Nomaru Hiroko, Donna M McDonald-McGinn, Matthew Hestand, Wolfram Demaerel, Liangtian Zhang, Yingjie Zhao, Francisco Ujueta, Jidong Shan, Cristina Montagna, Deyou Zheng, Terrence B Crowley, Leila Kushan-Wells, Carrie E Bearden, Wendy R Kates, Doron Gothelf, Maude Schneider, Stephan Eliez, Jeroen Breckpot, Ann Swillen, Jacob Vorstman, Elaine Zackai, Felipe Gonzalez Benavides, Gabriela M Repetto, Beverly S Emanuel, Anne S Bassett, Joris R Vermeesch, Christian R Marshall, Bernice E Morrow
Recurrent, de novo, meiotic non-allelic homologous recombination events between low copy repeats, termed LCR22s, leads to the 22q11.2 deletion syndrome (22q11.2DS; velo-cardio-facial syndrome/DiGeorge syndrome). Although most 22q11.2DS patients have a similar sized 3 million base pair (Mb), LCR22A-D deletion, some have nested LCR22A-B or LCR22A-C deletions. Our goal is to identify additional recurrent 22q11.2 deletions associated with 22q11.2DS, serving as recombination hotspots for meiotic chromosomal rearrangements...
January 18, 2018: Human Molecular Genetics
Aaron Ermel, Marcia L Shew, Teresa M Imburgia, Matt Brown, Brahim Qadadri, Yan Tong, Darron R Brown
PURPOSE: To assess whether HPV 16 originally detected in adolescent women can be redetected in adulthood. METHODS: A convenience sample of 27 adult women with known HPV 16 detection during adolescence was assessed for HPV 16 redetection. A comparison of the long control region (LCR) DNA sequences was performed on some of the original and redetected HPV 16 isolates. RESULTS: Median age at reenrollment was 27.5 years (interquartile range of 26...
January 16, 2018: Papillomavirus Research
M Beaussier, Y Parc, J Guechot, M Cachanado, A Rousseau, T Lescot
AIM: The abdominal incision for specimen extraction could trigger postoperative pain after laparoscopic colorectal resections (LCR). Continuous Wound Infusion (CWI) of ropivacaine may be a valuable option for postoperative analgesia. This study was undertaken to evaluate the potential benefits of ropivacaine CWI on pain relief, metabolic stress reaction, prevention of wound hyperalgesia and residual incisional pain after LCR. A subgroup with intravenous lidocaine infusion (IVL) was added to discriminate between the peripheral and systemic effects of local anaesthetic infusions...
January 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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