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Topical Tranexamic acid

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https://www.readbyqxmd.com/read/27856355/combined-intravenous-and-topical-tranexamic-acid-versus-intravenous-use-alone-in-primary-total-knee-and-hip-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#1
REVIEW
Jie Shang, Haibo Wang, Bai Zheng, Min Rui, Yehua Wang
OBJECTIVE: The tranexamic acid (TXA) can reduce surgical perioperative blood loss. However, the optimal regimen of tranexamic acid remains controversial. The purpose of this meta-analysis was to compare the efficacy and safety of combined intravenous and topical tranexamic acid versus intravenous use alone in primary total knee and hip arthroplasty. METHODS: PubMed, EMbase, Cochrane library and OVID were searched. Eligible randomized controlled trials (RCTs) evaluating combined intravenous and topical TXA versus intravenous alone in primary total knee and hip arthroplasty were included...
November 14, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27837327/topical-versus-intravenous-tranexamic-acid-in-total-knee-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#2
Shangquan Wang, Xinxia Gao, Yan An
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug used widely to prevent bleeding in total knee arthroplasty (TKA). However, there is no consensus regarding the administration routes of TXA. This meta-analysis aimed to investigate the efficacy of topical (intra-articular) versus intravenous TXA in reducing blood loss and transfusion rate in patients who underwent TKA. METHOD: We conducted a Pubmed, EMBASE, Cochrane Library, and Web of Science search for randomized controlled trials (RCTs) comparing topical versus intravenous TXA in TKA...
November 11, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27769971/role-of-topical-tranexamic-acid-in-the-management-of-idiopathic-anterior-epistaxis-in-adult-patients-in-the-emergency-department
#3
Jill K Logan, Hardin Pantle
PURPOSE: The role of topical tranexamic acid in the management of anterior epistaxis in adult patients in the emergency department (ED) is examined. SUMMARY: The use of alternative agents for the treatment of epistaxis before the use of nasal packing may be reasonable due to patient discomfort, potential complications, and the need for follow-up with a healthcare provider for packing removal. One such agent is tranexamic acid. Two published studies evaluated the off-label use of topical tranexamic acid for the treatment of epistaxis...
November 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27762649/skin-permeation-and-retention-of-topical-bead-formulation-containing-tranexamic-acid
#4
Ajay Vijayakumar, Rengarajan Baskaran, Bong Kyu Yoo
The objective of this study is to develop a topical bead formulation of tranexamic acid (TA) which can be used concomitantly with laser treatment. The bead formulation of TA (TAB) was successfully prepared by fluidized bed drying method. Physicochemical properties of the TAB were evaluated in terms of chemical stability of TA and differential scanning calorimetry. TA in the bead was stable up to six months at 25°C and existed as amorphous state. In vitro skin permeation and in vivo skin retention of TA in the beads were significantly higher compared to a commercial product...
November 23, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27762489/comparison-of-the-therapeutic-efficacy-and-safety-of-combined-oral-tranexamic-acid-and-topical-hydroquinone-4-treatment-vs-topical-hydroquinone-4-alone-in-melasma-a-parallel-group-assessor-and-analyst-blinded-randomized-controlled-trial-with-a-short-term-follow
#5
Vahideh Lajevardi, Afsaneh Ghayoumi, Robabeh Abedini, Hamed Hosseini, Azadeh Goodarzi, Zahra Akbari, Kosar Hedayat
BACKGROUND: Melasma's high prevalence and profound psychological impact on patients necessitate efficacious, economical, and safe therapeutic interventions. Adjunctive therapies such as tranexamic acid (TA) can enhance the therapeutic effect of standard treatments like hydroquinone 4% cream (HQ). OBJECTIVE: To conduct an assessor- and analyst-blinded, parallel, superiority, randomized controlled trial to compare the clinical efficacy and safety of oral TA plus HQ vs...
October 20, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27761223/topical-versus-intravenous-administration-of-tranexamic-acid-in-primary-total-hip-arthroplasty-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Sammy A Hanna, Anoop Prasad, Joshua Lee, Pramod Achan
Tranexamic acid (TA) is widely used by orthopedic surgeons to decrease blood loss and the need for transfusion following total hip arthroplasty (THA). Although both intravenous and topical applications are described in the literature, there remains no consensus regarding the optimal regimen, dosage and method of delivery of TA during THA. In addition, concerns still exist regarding the risk of thromboembolic events with intravenous administration. The purpose of this meta-analysis was to compare the efficacy and safety of topical versus intravenous administration of TA in THA...
September 19, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/27741100/topical-versus-systemic-tranexamic-acid-after-total-knee-and-hip-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#7
Yongcai Chen, Zhuo Chen, Shuo Cui, Zhiyang Li, Zhengjiang Yuan
BACKGROUND: Tranexamic acid (TXA) is an antifibrinolytic drug widely used to reduce blood loss during joint replacements, including total knee arthroplasty (TKA) and total hip arthroplasty (THA). However, there is no final consensus regarding the composition of an optimal administration of TXA regime between topical and systemic (intravenous). The purpose of our study was to compare the efficacy of topical and intravenous (IV) regimen of TXA during TKA and THA. METHODS: Five relevant electronic online databases, PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science and Chinese Biomedical Database were systematically searched in November 2015...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27709420/cochrane-in-corr-%C3%A2-topical-application-of-tranexamic-acid-for-the-reduction-of-bleeding-review
#8
Nathan Evaniew, Mohit Bhandari
No abstract text is available yet for this article.
October 5, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27706534/topical-tranexamic-acid-in-total-knee-arthroplasty-patients-with-increased-thromboembolic-risk
#9
Jonathon Spanyer, Jay Patel, Eric Emberton, Langan S Smith, Arthur L Malkani
The purpose of this study was to evaluate the efficacy and safety profiles of topical tranexamic acid (TXA) in patients undergoing elective total knee arthroplasty (TKA) with comorbid conditions precluding them from intravenous (IV) TXA use. A total of 104 patients were divided into two groups: 47 in the normal-risk group and 57 in the high-risk group, with the latter representing those with one or more risk factors for venous thromboembolism (VTE). Demographics were similar between groups, and there were no differences with regard to postoperative changes in hemoglobin (- 3...
October 5, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27633946/combined-administration-of-iv-and-topical-tranexamic-acid-is-not-superior-to-either-individually-in-primary-navigated-tka
#10
Eun-Kyoo Song, Jong-Keun Seon, Jatin Prakash, Young-Jun Seol, Yong Jin Park, Cheng Jin
BACKGROUND: In this study, we tried to assess if combined method (intravenous [IV] and topical) of tranexamic acid (TXA) administration, which has been shown to be superior in conventional arthroplasty, has similar effect in navigational arthroplasty compared to administration of drug either individually. METHODS: In present randomized control trial, 200 patients were randomly divided in one of the 4 groups using computer-generated tables-control, IV, intraarticular, and combined...
July 6, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27631446/-the-new-german-guideline-on-postpartum-haemorrhage-pph-essential-aspects-for-coagulation-and-circulatory-therapy
#11
Heiko Lier, Dietmar Schlembach, Wolfgang Korte, Christian von Heymann, Susanne Steppat, Maritta Kühnert, Holger Maul, Wolfgang Henrich, Werner Rath, Jürgen Wacker, Franz Kainer, Daniel Surbek, Hanns Helmer
Worldwide, post-partum haemorrhage (PHH) remains one of the leading causes for maternal mortality. The German Society of Gynaecology and Obstetrics, the German Midwifes' Society, the German Society of Thrombosis and Haemostasis and the German Society of Anaesthesiology and Intensive Care updated the former guideline. The resulting recommendations are the results of a structured literature search and a formal consensus process and contain all aspects of PPH including diagnosis, causes, risk factors and therapy...
September 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27603364/comparison-of-efficacy-and-safety-of-topical-versus-intravenous-tranexamic-acid-in-total-hip-arthroplasty-a-meta-analysis
#12
Jian Li, Zhijie Zhang, Jie Chen
BACKGROUND: The study aimed to compare the effectiveness and safety of topical versus intravenous (IV) tranexamic acid (TXA) for reducing blood loss in primary total hip arthroplasty (THA). METHODS: This systematic review and meta-analysis were performed according to the preferred reporting items for systematic reviews and meta-analyses statement criteria. PubMed, Embase, the Cochrane Library, Web of Science, Chinese Biomedicine Literature (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), and Google Scholar were searched for randomized controlled trials (RCTs) and non-RCTs that compare topical versus IV-TXA administration for reducing blood loss during TKA from their inception to February, 2016...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27599329/effect-of-topical-intranasal-therapy-on-epistaxis-frequency-in-patients-with-hereditary-hemorrhagic-telangiectasia-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Kevin J Whitehead, Nathan B Sautter, Justin P McWilliams, Murali M Chakinala, Christian A Merlo, Maribeth H Johnson, Melissa James, Eric M Everett, Marianne S Clancy, Marie E Faughnan, S Paul Oh, Scott E Olitsky, Reed E Pyeritz, James R Gossage
IMPORTANCE: Epistaxis is a major factor negatively affecting quality of life in patients with hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu disease). Optimal treatment for HHT-related epistaxis is uncertain. OBJECTIVE: To determine whether topical therapy with any of 3 drugs with differing mechanisms of action is effective in reducing HHT-related epistaxis. DESIGN, SETTING, AND PARTICIPANTS: The North American Study of Epistaxis in HHT was a double-blind, placebo-controlled randomized clinical trial performed at 6 HHT centers of excellence...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27591836/a-systematic-review-of-anti-thrombotic-therapy-in-epistaxis
#14
K M Musgrave, J Powell
There is limited guidance available to clinicians regarding the management of antithrombotic therapy during epistaxis, whilst there has been an increase in the use of anticoagulation and antiplatelet therapy. In addition, the introduction of direct oral anticoagulants (DOACs), such as dabigatran and rivaroxaban, over the last decade has significantly increased the complexity of managing the anticoagulated epistaxis patient. We undertook a systemic literature review investigating potential management strategies for each class of anti-thrombotic therapy during epistaxis...
September 4, 2016: Rhinology
https://www.readbyqxmd.com/read/27587787/the-combined-effect-of-administration-of-intravenous-and-topical-tranexamic-acid-on-blood-loss-and-transfusion-rate-in-total-knee-arthroplasty-combined-tranexamic-acid-for-tka
#15
Z F Yuan, H Yin, W P Ma, D L Xing
OBJECTIVES: Tranexamic acid (TXA) is an antifibrinolytic agent used as a blood-sparing technique in total knee arthroplasty (TKA), and is routinely administered by intravenous (IV) or intra-articular (IA) injection. Recently, a novel method of TXA administration, the combined IV and IA application of TXA, has been applied in TKA. However, the scientific evidence of combined administration of TXA in TKA is still meagre. This meta-analysis aimed to investigate the efficacy and safety of combined IV and IA TXA in patients undergoing TKA...
August 2016: Bone & Joint Research
https://www.readbyqxmd.com/read/27574259/topical-tranexamic-acid-versus-autotransfusion-after-total-knee-arthroplasty
#16
Y Guzel, O T Gurcan, U H Golge, T C Dulgeroglu, H Metineren
PURPOSE: To compare the use of topical tranexamic acid (TXA) with postoperative autologous transfusion (PAT) in terms of blood loss, need for allogeneic blood transfusion, and cost-effectiveness. METHODS: Records of 25 men and 125 women (mean age, 67 years) who underwent primary unilateral total knee arthroplasty (TKA) and were randomised to the PAT group (n=50), topical TXA group (n=50), or routine drainage group (control) [n=50] were reviewed. Pre- and post-operative haemoglobin level, total postoperative drainage volume, and the need for allogeneic blood transfusion were recorded...
August 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27498390/blood-sparing-efficacy-of-oral-tranexamic-acid-in-primary-total-hip-arthroplasty
#17
Qunn Jid Lee, Wai Yee Esther Chang, Yiu Chung Wong
BACKGROUND: Tranexamic acid (TXA) has been shown to be effective in reducing blood loss, hemoglobin drop, and blood transfusion in primary total hip arthroplasty. Most studies used intravenous form or topical form. This study was to assess the blood-sparing efficacy and safety of oral TXA in total hip arthroplasty. METHODS: Patients with primary total hip arthroplasty from 2012 to 2015 were recruited. Trial group with 1 gm of oral TXA 2 hours preoperatively, and 6 hours and 12 hours postoperatively was compared with the control group without drug...
July 6, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27455842/peri-articular-tranexamic-acid-injection-in-total-knee-arthroplasty-a-randomized-controlled-trial
#18
P Pinsornsak, S Rojanavijitkul, S Chumchuen
BACKGROUND: Intravenous tranexamic acid (IV TXA) is one of the most effective agents in use for reducing blood loss following total knee arthroplasty (TKA) but its safety regarding venous thromboembolic events (VTEs) remains in question. The direct, local application of TXA may reduce systemic toxicity whilst maintaining good or better bleeding control compared to IV TXA. The topical application of TXA via Hemovac drains has been reported previously with good results. However, there are no data on peri-articular TXA injections during TKA...
July 26, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27417102/intravenous-versus-topical-tranexamic-acid-administration-in-primary-total-knee-arthroplasty-a-meta-analysis
#19
Young-Soo Shin, Jung-Ro Yoon, Hoon-Nyun Lee, Se-Hwan Park, Dae-Hee Lee
PURPOSE: This meta-analysis was designed to compare the effectiveness and safety of intravenous (IV) versus topical administration of tranexamic acid (TXA) in patients undergoing primary total knee arthroplasty (TKA) by evaluating the need for allogenic blood transfusion, incidence of postoperative complications, volume of postoperative blood loss, and change in haemoglobin levels. METHODS: Studies were included in this meta-analysis to check whether they assessed the allogenic blood transfusion rate, postoperative complications including pulmonary thromboembolism (PTE) or deep vein thrombosis (DVT), volume of postoperative blood loss via drainage, estimated blood loss, total blood loss, and change in haemoglobin levels before and after surgery in primary TKA with TXA administered through both the IV and topical routes...
July 14, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27391635/topical-hemostatic-anesthetic-solution-to-reduce-bleeding-during-mohs-micrographic-surgery-a-case-control-study
#20
Isaac Zilinsky, Tamar Brutman Barazani, Boris Shenkman, Oren Weisman, Nimrod Farber, Uriel Martinowitz
BACKGROUND: Between stages of Mohs micrographic surgery, the wound is dressed and the patient waits for the histopathological results.<br/> OBJECTIVE: To investigate the efficacy of a hemostatic-anesthetic solution-impregnated gauze in decreasing bleeding between Mohs stages.<br/> MATERIALS AND METHODS: Twenty patients were treated with a hemostatic-anesthetic solution composed of tranexamic acid, adrenaline, and lidocaine (TAL), and 20 others were treated with a saline solution for control...
July 1, 2016: Journal of Drugs in Dermatology: JDD
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