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Topical Tranexamic acid

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https://www.readbyqxmd.com/read/28765007/combined-intravenous-topical-and-oral-tranexamic-acid-administration-in-total-knee-replacement-evaluation-of-safety-in-patients-with-previous-thromboembolism-and-effect-on-hemoglobin-level-and-transfusion-rate
#1
Joris A Jansen, Joost R C Lameijer, Barbara A M Snoeker
BACKGROUND: The aims of this study were to investigate the safety of combined intravenous, oral and topical tranexamic acid (TXA) in primary total knee replacement. We assessed dose-related efficacy on hemoglobin level, transfusion, length of stay and thromboembolic complications. In addition, TXA safety in patients with previous history of thromboembolism >12months ago was monitored specifically. METHODS: From January 2013 until January 2016, 922 patients were included who received TXA after primary total knee replacement...
July 29, 2017: Knee
https://www.readbyqxmd.com/read/28757131/oral-tranexamic-acid-reduces-transfusions-in-total-knee-arthroplasty
#2
Roger E Perreault, Christine A Fournier, David A Mattingly, Richard P Junghans, Carl T Talmo
BACKGROUND: Tranexamic acid (TXA) reduces intraoperative blood loss and transfusions in patients undergoing total knee arthroplasty. Although numerous studies demonstrate the efficacy of intravenous and topical TXA in these patients, few demonstrate the effectiveness and appropriate dosing recommendations of oral formulations. METHODS: A retrospective cohort study was performed to evaluate differences in transfusion requirements in patients undergoing primary unilateral total knee arthroplasty with either no TXA (n = 866), a single-dose of oral TXA (n = 157), or both preoperative and postoperative oral TXA (n = 1049)...
April 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28748406/therapeutic-effects-of-topical-tranexamic-acid-in-comparison-with-hydroquinone-in-treatment-of-women-with-melasma
#3
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
July 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28746213/is-combined-topical-and-intravenous-tranexamic-acid-superior-to-single-use-of-tranexamic-acid-in-total-joint-arthroplasty-a-meta-analysis-from-randomized-controlled-trials
#4
REVIEW
Liqing Yang, Shuai Du, Yuefeng Sun
BACKGROUND: To compare the efficacy and safety of the combined application of both intravenous and topical tranexamic acid (TXA) versus the single use of either application in patients with total knee and hip arthroplasty (TKA and THA). METHODS: Potentially relevant studies were identified from electronic databases including Medline, PubMed, Embase, ScienceDirect, and the Cochrane Library. Randomized control trials (RCTs) of patients prepared for total joint arthroplasty that compared combined TXA with placebo were retrieved...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28742015/topical-tranexamic-acid-reduces-transfusion-rates-in-simultaneous-bilateral-total-knee-arthroplasty-a-retrospective-case-series
#5
Christopher Kim, Sam S Park, Herman S Dhotar, Anthony V Perruccio, Michael G Zywiel, J Roderick Davey
BACKGROUND: Topical tranexamic acid (TA) has been reported to be effective in reducing postoperative bleeding and transfusions after TKA. The main objective of this study was to retrospectively assess the effectiveness and safety of topical TA administration in patients undergoing simultaneous bilateral TKA. METHODS: We conducted a retrospective chart review of consecutive cohorts of patients undergoing simultaneous bilateral TKA. We compared the patients who received TA with patients from a similar time frame who did not receive TA...
August 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#6
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28707406/quantitative-efficacy-of-topical-administration-of-tranexamic-acid-on-postoperative-bleeding-in-total-knee-arthroplasty
#7
Ruijuan Xu, Dongquan Shi, Weihong Ge, Qing Jiang
AIMS: Topical tranexamic acid (TXA) was used in patients undergoing total knee arthroplasty to reduce perioperative blood loss. However, the optimal dosing regimen remains undetermined. The aim of the present study was to quantitatively evaluate the effect of topical TXA on the reduction of postoperative drainage, and identify the dosing regimen factors affecting the efficacy of topical TXA. METHODS: Model based meta-analysis (MBMA) was used to evaluate the efficacy of topical TXA and the dosing regimen factors influencing clinical efficacy...
July 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28691188/tranexamic-acid-in-total-knee-arthroplasty-mixed-treatment-comparisons-and-recursive-cumulative-meta-analysis-of-randomized-controlled-trials-and-cohort-studies
#8
Kannan Sridharan, Gowri Sivaramakrishnan
Tranexamic acid (TXA) has been shown to be effective in patients with total knee arthroplasty (TKA) in clinical studies with no consensus with regard to the most appropriate route of administration. We conducted a network meta-analysis to compare the evidences available on efficacy and safety of TXA in TKA. Electronic databases were searched for randomized, clinical trials and cohort studies that evaluated TXA in TKA. Publication bias, risk of bias and inconsistencies were assessed. Direct and indirect comparisons were carried out for blood transfusion rate and incidence of thrombotic complications...
July 10, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28662956/tranexamic-acid-in-knee-surgery-study-a-multicentered-randomized-controlled-trial
#9
Marinus D J Stowers, James Aoina, Andrew Vane, Vaughan Poutawera, Andrew G Hill, Jacob T Munro
BACKGROUND: Postoperative anemia following elective arthroplasty can lead to prolonged hospital stay and delays in rehabilitation and is often poorly tolerated in patients with cardiovascular disease. Tranexamic acid (TXA) has been shown to reduce perioperative blood loss in total knee arthroplasty (TKA). However, questions over its optimal route of administration remain. METHODS: A double-blinded, placebo, multicentered, randomized, controlled trial investigating the efficacy of topical and systemic routes of a single intraoperative dose (1...
June 9, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28649780/therapeutic-efficacy-and-safety-of-oral-tranexamic-acid-and-that-of-tranexamic-acid-local-infiltration-with-microinjections-in-patients-with-melasma-a-comparative-study
#10
R Sharma, V K Mahajan, K S Mehta, P S Chauhan, R Rawat, T N Shiny
BACKGROUND: Tranexamic acid (TXA) has been used orally, intravenously, topically and intradermally (microinjection, microneedling) for treating melasma. However, the comparative efficacy of these different routes of administration remains underevaluated. AIM: To ascertain the comparative efficacy of different routes of administration of TXA. METHODS: In total, 100 consecutive patients with melasma (8 men, 92 women, age range 18-55 years) were randomly assigned to one of two groups comprising 50 patients each...
June 25, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28648705/an-aprotinin-containing-fibrin-sealant-does-not-reduce-blood-loss-in-total-hip-arthroplasty
#11
Sean M Kearns, Hannah N Kuhar, Daniel D Bohl, Brett R Levine
BACKGROUND: Fibrin sealants are topical agents used to reduce perioperative blood loss; however, their efficacy in total hip arthroplasty (THA) remains uncertain. The purpose of this study was to determine if a fibrin sealant containing aprotinin as an antifibrinolytic agent, TISSEEL (Baxter, Deerfield, IL), reduces postoperative blood loss and transfusion during THA when compared with intravenous (IV) tranexamic acid (TXA) and control groups. METHODS: Three retrospective uniform cohorts of primary THA procedures were identified, from a prospectively maintained database: 1 group who received TISSEEL, 1 group who received 1 g IV TXA, and 1 group who received neither (control)...
May 31, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28602763/combined-versus-single-application-of-tranexamic-acid-in-total-knee-and-hip-arthroplasty-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
M M Peng Zhang, M M Jifeng Li, M M Xiao Wang
OBJECTIVE: To compare the efficacy and safety of the combined application of both intravenous and topical tranexamic acid versus the single use of either application in patients with total knee and hip arthroplasty. METHODS: Potentially relevant studies were identified from electronic databases including Medline, PubMed, Embase, ScienceDirect and the Cochrane Library. Patients undergoing primary total knee and hip arthroplasty were included in our studies, with an experimental group that received combined intravenous and topical application of tranexamic acid and a control group that received a single application of tranexamic acid or normal saline...
July 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28559649/tranexamic-acid-in-total-hip-arthroplasty-a-recursive-cumulative-meta-analysis-of-randomized-controlled-trials-and-assessment-of-publication-bias
#13
REVIEW
Kannan Sridharan, Gowri Sivaramakrishnan
INTRODUCTION: TXA has been evaluated in THA in several randomized controlled trials for the past 16 years. We attempted to evaluate the trends in the evidence using recursive cumulative meta-analysis and publication bias using Rosenthal and 'Trim and Fill' methods. METHODS: Electronic databases were searched for randomized controlled clinical trials comparing TXA with either placebo (or no TXA administration) or TXA, administered through different routes in patients with osteoarthritis or osteonecrosis of the hip who underwent THA...
September 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28542107/efficacy-and-safety-of-topical-use-of-tranexamic-acid-in-reducing-blood-loss-during-primary-lumbar-spinal-surgery-a-retrospective-case-control-study
#14
Zhinan Ren, Shugang Li, Lin Sheng, Qianyu Zhuang, Zheng Li, Derong Xu, Xin Chen, Pengxiang Jiang, Xiao Zhang
STUDY DESIGN: A retrospective case-control study. OBJECTIVE: To compare postoperative blood loss, amount of allogeneic blood transfusion, removal time of drainage tube, length of hospital stay, and complications associated with tranexamic acid. SUMMARY OF BACKGROUND DATA: Spinal fusion surgery can be associated with significant blood loss. To the best of our knowledge, very few published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on decreasing the blood loss in patients undergoing posterior lumbar spinal fusions...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28538381/is-combined-topical-and-intravenous-tranexamic-acid-superior-to-intravenous-tranexamic-acid-alone-for-controlling-blood-loss-after-total-hip-arthroplasty-a-meta-analysis
#15
REVIEW
Hua Zhang, Guoping He, Caihong Zhang, Baichao Xu, Xuejiao Wang, Chaowei Zhang
BACKGROUND: We performed a meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of combined intravenous (IV) and topical tranexamic acid (TXA) with IV-TXA alone for controlling blood loss in patients following primary total hip arthroplasty (THA). METHODS: PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the Google database, the Chinese Wanfang database, and the China National Knowledge Infrastructure database were searched to identify studies comparing combined IV and topical TXA with IV-TXA alone in patients who were prepared for THA...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489798/efficacy-of-functional-microarray-of-microneedles-combined-with-topical-tranexamic-acid-for-melasma-a-randomized-self-controlled-split-face-study
#16
RANDOMIZED CONTROLLED TRIAL
Yang Xu, Renyan Ma, Juliandri Juliandri, Xiaoyan Wang, Bai Xu, Daguang Wang, Yan Lu, Bingrong Zhou, Dan Luo
To evaluate the efficacy of a functional microarray of microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women in China.Thirty female subjects with melasma were enrolled in this study. The left or right side of the face was chosen randomly to be pretreated with a functional microarray of MNs, followed by topical 0.5% TA solution once per week for 12 weeks. The other half-face was the control, treated with a sham device plus topical 0.5% TA solution. At baseline and at weeks 4, 8, and 12 of treatment, clinical (photographic) evaluations and parameters determined by Visia were recorded...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28475556/high-concentrations-of-tranexamic-acid-inhibit-ionotropic-glutamate-receptors
#17
Irene Lecker, Dian-Shi Wang, Kirusanthy Kaneshwaran, C David Mazer, Beverley A Orser
BACKGROUND: The antifibrinolytic drug tranexamic acid is structurally similar to the amino acid glycine and may cause seizures and myoclonus by acting as a competitive antagonist of glycine receptors. Glycine is an obligatory co-agonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors. Thus, it is plausible that tranexamic acid inhibits NMDA receptors by acting as a competitive antagonist at the glycine binding site. The aim of this study was to determine whether tranexamic acid inhibits NMDA receptors, as well as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainate subtypes of ionotropic glutamate receptors...
July 2017: Anesthesiology
https://www.readbyqxmd.com/read/28455182/comparison-of-3-routes-of-administration-of-tranexamic-acid-on-primary-unilateral-total-knee-arthroplasty-a-prospective-randomized-controlled-study
#18
Xiangwei Yuan, Bin Li, Qiaojie Wang, Xianlong Zhang
BACKGROUND: The mode of administration for tranexamic acid (TXA) to significantly reduce the decrease in hemoglobin (Hb), number of transfusions, relevant costs, and side effects in patients undergoing primary unilateral total knee arthroplasty (TKA) has not been resolved. METHODS: A total of 560 patients undergoing primary unilateral TKA were randomized into 4 groups: intravenous group (140 patients receiving 2 doses of 20 mg/kg intravenous TXA), topical group (140 patients administered 3...
April 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28395389/tranexamic-acid-and-computer-assisted-surgery-in-cemented-and-cementless-total-knee-arthroplasty-are-the-effects-additive-for-blood-conservation
#19
Michael Fleischman, Mark Hood, Mary Ziemba-Davis, R Michael Meneghini
INTRODUCTION: Efforts continue to minimize blood loss associated with total knee arthroplasty (TKA). The primary objective of this study was to determine whether computer-assisted surgery (CAS) and tranexamic acid (TXA) were additive in minimizing blood loss in cemented TKA. The secondary objective was to assess the combined effectiveness of CAS and TXA in cementless TKA. MATERIALS AND METHODS: A retrospective study of 393 consecutive primary TKAs with cemented and cementless fixation was performed...
April 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28395370/intra-articular-tranexamic-acid-in-primary-total-knee-arthroplasty-meta-analysis
#20
Joseph T Moskal, Susan G Capps
Total knee arthroplasty (TKA) is associated with an increased need for blood transfusions and thus an increase in risks associated with blood transfusion such as transfusion reactions, infections, fluid overload, and altered mental status. Tranexamic acid (TXA) is an antifibrinolytic medication that can reduce perioperative blood loss in TKA. However, the best method of delivery has not been defined although topical intra-articular TXA (IA-TXA) may have a theoretical advantage as it is applied directly when and where it is needed to control bleeding...
April 10, 2017: Journal of Knee Surgery
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