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Anterior Uveitis

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https://www.readbyqxmd.com/read/29028408/tonic-pupil-in-cytomegalovirus-anterior-uveitis-in-an-immunocompetent-adult-male-a-case-report
#1
Kalpana Babu, Deepika C Parameswarappa, Bhagya Sudheer
PURPOSE: To report an interesting case of development of tonic pupil in an immunocompetent male with cytomegalovirus (CMV) anterior uveitis. METHODS: Retrospective case report Results: A 30-year-old Iranian healthy male was diagnosed to have Posner-Schlossman syndrome (OS). Aqueous tap was positive for CMV by multiplex Polymerase chain reaction (PCR). Adequate control of inflammation and Intraocular pressures (IOP) were achieved with topical steroids, ganciclovir gel, and antiglaucoma medications...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29023181/review-for-disease-of-the-year-varicella-zoster-virus-induced-anterior-uveitis
#2
Ilknur Tugal-Tutkun, Luca Cimino, Yonca Aydin Akova
Varicella zoster virus (VZV)-induced anterior uveitis (AU) may complicate the course of primary varicella infection typically seen in children. In adults, especially with advanced age, VZV AU is more commonly associated with herpes zoster ophthalmicus (HZO) with or without skin rash affecting the distribution of the ophthalmic nerve due to reactivation of the latent VZV in the trigeminal ganglion. While it is typically a mild self-limiting AU in primary infection, HZO AU is often accompanied by keratitis, may have a chronic recurrent course, and lead to sectoral iris atrophy, pupillary distortion, and ocular hypertension...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29023165/clinical-characteristics-of-ocular-sarcoidosis-a-population-based-study-1976-2013
#3
Patompong Ungprasert, Andrea A Tooley, Cynthia S Crowson, Eric L Matteson, Wendy M Smith
PURPOSE: To characterize the epidemiology and clinical characteristics of ocular involvement in patients with systemic sarcoidosis. METHODS: An inception cohort of patients with systemic sarcoidosis in 1976-2013 in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Medical records of those patients were then reviewed for ocular involvement. RESULTS: A total of 345 incident cases of systemic sarcoidosis were identified...
October 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29022761/noninvasive-ocular-drug-delivery-system-of-dexamethasone-sodium-phosphate-in-the-treatment-of-experimental-uveitis-rabbit
#4
Kongnara Papangkorn, Eri Prendergast, John W Higuchi, Balbir Brar, William I Higuchi
PURPOSE: To investigate the efficacy and safety of dexamethasone sodium phosphate administered through Visulex system (DSP-Visulex) in treating experimental uveitis. METHODS: Uveitis was induced in rabbits by subcutaneous injections of complete Freund's adjuvant and an intravitreal injection of H37RA antigen. After induction, the animals of the control group received no treatment and the others received various treatment regimens of DSP-Visulex. Each regimen was different in DSP strength (4%, 8%, and 15%), application time, or treatment frequency...
October 12, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29020537/challenges-of-diagnosing-viral-anterior-uveitis
#5
Fahriye Groen-Hakan, Kalpana Babu, Ilknur Tugal-Tutkun, Kessara Pathanapithoon, Joke H de Boer, Justine R Smith, Jolanda D F de Groot-Mijnes, Aniki Rothova
The viral causes of anterior uveitis (AU) emerged with the use of novel molecular diagnostic tests and serologic tests adapted for small volumes (Goldmann-Witmer Coefficient). The viral causes of AU may be underestimated, and some of the presumed idiopathic AU cases will probably be proven to be of viral origin in the coming years. So far, a viral origin of AU was suspected in patients who presented with unilateral hypertensive AU. It is not clear which clinical presentations should raise a suspicion of viral etiology...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020500/tocilizumab-for-the-treatment-of-beh%C3%A3-et-uveitis-that-failed-interferon-alpha-and-anti-tumor-necrosis-factor-alpha-therapy
#6
Hilal Eser Ozturk, Merih Oray, Ilknur Tugal-Tutkun
PURPOSE: To report the results of tocilizumab (TCZ) treatment in patients with Behçet uveitis (BU) who had failed conventional, interferon alpha, and anti-Tumor necrosis factor-alpha therapy. METHODS: We reviewed the records of five patients with BU treated with monthly infusions of TCZ 8 mg/kg. Outcome measures were visual acuity, anterior chamber cells, laser flare meter (LFM) readings, vitreous haze, central macular thickness (CMT), and fluorescein angiography (FA) score...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020499/chikungunya-virus-infection-associated-with-encephalitis-and-anterior-uveitis
#7
Verônica França Diniz Rocha, Adriano Hasler Principe de Oliveira, Antonio Carlos Bandeira, Silvia Ines Sardi, Rodrigo Freaza Garcia, Samuel de Araújo Magalhães, Camila Alves Sampaio, Gubio Campos Soares
Chikungunya virus (CHIKV) is an RNA virus transmitted by Aedes mosquitoes. The clinical manifestations include fever, arthralgia, rash, and other atypical clinical findings including ocular lesions. We report the case of a 57-year-old man with meningoencephalitis and anterior uveitis due to CHIKV. The patient had developed bilateral anterior uveitis with iris atrophy and a cotton wool spot on the left eye, and his serum, urine, saliva, and cerebrospinal fluid were positive for CHIKV by RT-PCR. The spectrum of the ophthalmologic manifestations and its pathophysiology in cases of CHIKV infections needs to be better understood...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020487/clinical-characteristics-and-prognostic-factors-in-ankylosing-spondylitis-associated-uveitis
#8
Ji Hwan Lee, Moonjung Choi, Tyler Hyung Taek Rim, Sung Chul Lee, Christopher Seungkyu Lee
PURPOSE: To identify the clinical features and prognostic factors of uveitis associated with ankylosing spondylitis (AS). METHODS: This retrospective, interventional case series study reviewed the medical records of 91 AS patients with uveitis. RESULTS: The characteristics of AS-associated uveitis included male preponderance (70%), average onset in the fourth decade, unilateral manifestation (87.9%), and vitreous involvement or retinal vascular leakage (36...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28986635/-aphakic-artisan-verisyse-iols-as-retropupillary-implants-video-article
#9
REVIEW
V Besgen, W Sekundo
The retropupillary implantation of an iris claw intraocular lens (IOL) is an uncomplicated and fast technique for rehabilitation of aphakic eyes without any capsular structures and is presented in a video in the online version of this article. A complete anterior pars plana vitrectomy as shown in our case or an extensive preceding anterior vitrectomy as well as an intact iris are prerequisites. Special instruments for the implantation and fixation of the IOL are available to optimize the operative procedure...
October 6, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28985804/adult-patients-with-uveitis-associated-with-juvenile-idiopathic-arthritis-a-retrospective-review
#10
Anton M Kolomeyer, Elliot S Crane, Yufei Tu, Dan Liu, David S Chu
OBJECTIVE: To describe clinical characteristics and outcomes of adults with uveitis associated with juvenile idiopathic arthritis (JIA). METHODS: Retrospective chart review from 2001 to 2014 of adult patients with JIA and follow-up ≥2 months. Outcome measures included visual acuity, intraocular pressure (IOP), inflammation grade, ocular findings/complications, immunosuppressive therapies, and surgeries. RESULTS: Nineteen patients were included (95% female, 84% bilateral uveitis, 47% anterior uveitis)...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28983414/anti-tnf%C3%AE-therapy-and-switching-in-severe-uveitis-related-to-vogt-koyanagi-harada-syndrome
#11
Bryan Josue Flores Robles, Juan Blanco-Madrigal, Abel Alejandro Sanabria Sanchinel, Dixie Huntley Pascual, Rosario Demetrio-Pablo, Ricardo Blanco
The study aimed to describe the effectiveness of switching the anti-TNFα agent when an acceptable clinical response has not been obtained with the first anti-TNFα agent in patients with uveitis in VKH syndrome. Patients diagnosed with VKH syndrome being evaluated from the uveitis unit of a single tertiary hospital from January 1, 2000, to October 30, 2015. Patients who presented uveitis with an inadequate response to a first anti-TNFα and required switching to a second anti-TNFα were selected. Complete clinical response was assumed in patients whose visual acuity was normal and those who showed absence of inflammatory findings (inflammatory cells in the anterior chamber and vitritis) or absence of macular thickening in upon OCT...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28980900/one-year-in-review-2017-beh%C3%A3-et-s-syndrome
#12
REVIEW
Gulen Hatemi, Emire Seyahi, Izzet Fresko, Rosaria Talarico, Vedat Hamuryudan
A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome measures for clinical trials is continuing. Multimodal imaging using color fundus photography, fluorescein angiography, and optical coherence tomography is essential in visualising diagnostic features, detecting structural changes, and monitoring disease activity and response to treatment in Behçet's uveitis...
September 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28980216/tuberculous-uveitis-association-between-anti-tuberculous-therapy-and-clinical-response-in-a-non-endemic-country
#13
Kristina L Bajema, Kaivon Pakzad-Vaezi, Thomas Hawn, Kathryn L Pepple
BACKGROUND: The study aims to report the association between successful uveitis control following anti-tuberculous therapy (ATT) for uveitis associated with a positive tuberculosis (TB) screening test in a low endemic setting. A retrospective chart review of cases between 2010 and 2017 at a tertiary uveitis referral center in the United States of America was conducted. Subjects with any form of uveitis, a positive TB interferon-gamma release assay or tuberculin skin test, and negative evaluation for other causes of uveitis were included...
October 4, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/28977661/managing-morbidity-and-treatment-related-toxicity-in-patients-with-ankylosing-spondylitis
#14
Martin Bergman, Amy Lundholm
AS is the prototypical member of the family of spondyloarthropathies, and is characterized by seronegativity, axial predominance and new bone formation, which underlie symptoms of inflammatory back pain, enthesopathy and extra-articular manifestations, including anterior uveitis, psoriasis and colitis. Patients with AS typically experience a wide variety of morbidities. These include both morbidities related to the disease itself-most prominently progressive, irreversible, structural damage to the axial or peripheral skeleton-and morbidities stemming from treatments for the disease, including toxicities from NSAID use, and increased risk of infections and immunogenicity concerns with biologics...
August 4, 2017: Rheumatology
https://www.readbyqxmd.com/read/28973324/mapping-retinal-and-choroidal-thickness-in-unilateral-nongranulomatous-acute-anterior-uveitis-using-three-dimensional-1060-nm-optical-coherence-tomography
#15
Maximilian Gabriel, Robert Kruger, Farnusch Shams-Mafi, Boris Hermann, Behrooz Zabihian, Leopold Schmetterer, Wolfgang Drexler, Susanne Binder, Marieh Esmaeelpour
Purpose: To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Methods: Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly)...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28972025/differences-in-clinical-ocular-outcomes-between-exogenous-and-endogenous-endophthalmitis-caused-by-sporothrix-a-systematic-review-of-published-literature
#16
Max Carlos Ramírez Soto
BACKGROUND: Sporotrichosis is an implantation mycosis caused by Sporothrix species prevalent worldwide, which occasionally can also result in intraocular infection presenting as an exogenous or endogenous infection (disseminated sporotrichosis). Knowledge in its clinical recognition and management is limited. AIMS: To systematically review and analyse data from published literature with a view to comparing clinical outcomes between exogenous and endogenous endophthalmitis caused by Sporothrix...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28961042/orbital-inflammatory-syndrome-and-anterior-uveitis-a-case-series
#17
Eric L Crowell, Alden K Bahr, Ore-Ofe O Adesina, Ankur A Kamdar, Kartik S Kumar, Alla Goldberg
PURPOSE: To describe four cases of orbital inflammatory syndrome (OIS) with associated anterior uveitis that have presented within 2 years to our practice. METHODS: Charts of patients diagnosed with OIS from June 2013 to May 2015 were reviewed. RESULTS: Four patients, three children and one adult, presented with orbital swelling, pain, and varying degrees of vision loss. Treatment with intravenous methylprednisolone resulted in significant symptomatic improvement in all cases initially; when symptoms recurred, the patients had evidence of anterior uveitis...
September 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28960116/uveitis-in-patients-with-retinitis-pigmentosa-30-years-consecutive-data
#18
Parthopratim Dutta Majumder, Nitin Menia, Rupak Roy, Parveen Sen, Amala E George, Sudha K Ganesh, Jyotirmay Biswas
PURPOSE: To describe the clinical pattern of uveitis in patients with retinitis pigmentosa (RP) at a tertiary care eye hospital over a period of 30 years. METHODS: The medical records of 32 eyes of 22 patients of RP with uveitis were included in this study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), detailed laboratory investigations, and treatment. RESULTS: Mean age at presentation was 53.4 ± 18...
September 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28954117/do-you-know-this-syndrome-heerfordt-waldenstr%C3%A3-m-syndrome
#19
Rafael Cavanellas Fraga, Priscila Kakizaki, Neusa Yuriko Sakai Valente, Larissa Karine Leite Portocarrero, Mônica Fernandes Senise Teixeira, Priscilla Fernandes Senise
Heerfordt-Waldenström syndrome is a rare subacute variant of sarcoidosis, characterized by enlargement of the parotid or salivary glands, facial nerve paralysis and anterior uveitis. Granulomas with a peripheral lymphocyte deficit are found in the anatomic pathology of affected organs. It is normally self-limiting, with cure achieved between 12 and 36 months, but some prolonged cases have been reported. Diagnosis of the syndrome is clinical, and treatment depends on the degree of systemic impairment. Oral corticosteroids represent the first line treatment option...
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28947410/epidemiological-profile-of-patients-with-uveitis-in-boko-and-parakou-in-northern-b%C3%A3-nin
#20
K D Ayena, K Vonor, M A K Santos, I Sounouvou, L Odoulami-Yehouessi, J W Diallo, S Monteiro, Y E Nagbe, K Balo
To describe the epidemiology of uveitis in northern Bénin. This retrospective study carried out from records describing 10 years of uveitis care in 2 eye clinics in northern Bénin. The sample of 623 eyes with uveitis in 489 patients accounted for 1.0% of all consultations. A male predominance was observed with a sex-ratio of 1.5 (297 m/192 F). The patients' mean age was 35.7 ± 16.1 years, and the age range most often affected was 20-39 years. The uveitis was anterior in 32.3 %, posterior in 29.0 %, intermediate in 28...
August 1, 2017: Médecine et Santé Tropicales
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