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Anterior Uveitis

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https://www.readbyqxmd.com/read/28080174/the-use-of-topical-non-steroidal-anti-inflammatory-drugs-for-uveitic-cystoid-macular-edema
#1
Harry Petrushkin, Duncan Rogers, Carlos Pavesio
The use of topical non-steroidal anti-inflammatory drugs in the management of uveitic cystoid macular edema is controversial. In this letter, we review the literature and report our results from a retrospective case series of 281 patients taking topical nepafenac 0.1% for uveitic cystoid macular edema between 2010 and 2016. Over a 4-month period, there was a modest improvement in best-corrected visual acuity (0.66 ± 3.7 logMAR) and central macular thickness (69.8 ± 132.5 μm). Patients with idiopathic anterior uveitis and HLA-B*27-associated anterior uveitis recovered more vision while taking topical nepafenac 0...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28070744/changes-in-patterns-of-uveitis-at-a-tertiary-referral-center-in-northern-italy-analysis-of-990-consecutive-cases
#2
Cimino Luca, Aldigeri Raffaella, Marchi Sylvia, Mastrofilippo Valentina, Viscogliosi Fabiana, Coassin Marco, Soldani Annamaria, Savoldi Luisa, De Fanti Alessandro, Belloni Lucia, Zerbini Alessandro, Parmeggiani Maria, Chersich Matthew, Soriano Alessandra, Salvarani Carlo, Fontana Luigi
PURPOSE: The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients. METHODS: We reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies...
January 9, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28058157/unilateral-recurrent-anterior-uveitis-as-the-presenting-sign-of-bladder-carcinoma
#3
Günhal Şatırtav, Meryem Donbaloğlu, Refik Oltulu, Pembe Oltulu, Hürkan Kerimoğlu, Ahmet Özkağnıcı
A 79-year-old male patient was followed for unilateral uveitis with 3 attacks in 10 months, despite initial improvement with steroid therapy. The patient had visual acuity (VA) of counting fingers in right eye, hypopyon and vitritis with no chorioretinal lesions. The left eye was normal. The patient was evaluated for intraocular foreign body, intraocular lymphoma and associated systemic disease and malignancy. Computed tomography of the abdomen showed a mass in the bladder. Biopsy confirmed bladder carcinoma...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28052441/joint-hypermobility-and-oligoarticular-juvenile-idiopathic-arthritis-what-relationship
#4
Vanessa Cecchin, Francesca Sperotto, Marta Balzarin, Fabio Vittadello, Giorgia Martini, Francesco Zulian
AIM: Oligoarticular onset juvenile idiopathic arthritis (oJIA) is characterised by a prevalent lower limb involvement, antinuclear antibodies (ANA) positivity and high risk of anterior uveitis. As we observed that oJIA patients frequently present with joint hypermobility (JH), we investigated whether there was a relationship between oJIA and JH. METHODS: Our series consisted of children with oJIA, as defined by the International League of Associations for Rheumatology criteria, for whom complete clinical data of at least 2 years' duration were available...
January 4, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28035499/treatment-outcome-in-patients-with-presumed-tubercular-uveitis-at-a-tertiary-referral-eye-care-centre-in-singapore
#5
Leslie Ang, Aera Kee, Tun Hang Yeo, V G Dinesh, Su Ling Ho, Stephen C Teoh, Rupesh Agrawal
AIM: To report the clinical features and outcome of patients with presumed tubercular uveitis (TBU). METHODS: Retrospective analysis of patients with presumed TBU at a tertiary referral eye care centre in Singapore between 2007 and 2012 was done. Main outcome measures were failure of complete resolution of uveitis or recurrence of inflammation. RESULTS: Fifty three patients with mean age of 44.18 ± 15.26 years with 54.72% being males were included...
December 29, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28012873/posner-schlossman-syndrome
#6
REVIEW
Roly Megaw, Pankaj Kumar Agarwal
Posner-Schlossman syndrome (PSS), or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of non-granulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males . Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause...
December 21, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28010155/change-in-visual-function-in-uveitis-patients-after-treatment-an-experience-from-nepal
#7
Nita Sunam Gamal, Ranju Kharel Sitaula, Dev Narayan Shah
PURPOSE: To assess the change in visual function in uveitis patients after treatment. MATERIALS AND METHODS: This one and a half year prospective study was conducted among 180 new uveitis patients. A questionnaire was used to assess the visual function in uveitis cases and analysis of effect size change was also done. RESULTS: The male to female ratio was 1.3:1. The mean vision at presentation was 0.49 logMAR units, which improved to 0.39 logMAR units and 0...
December 23, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28010143/chikungunya-virus-infection-manifesting-as-intermediate-uveitis
#8
James Lin, Royce W S Chen, Albert Hazan, Michael Weiss
PURPOSE: To describe a case of intermediate uveitis caused by chikungunya virus infection in the Western Hemisphere. METHODS: Case report of a patient diagnosed with chikungunya infection presenting with blurry vision and floaters. RESULTS: Exam revealed a unilateral intermediate uveitis, with an extensive work-up positive for chikungunya virus immunoglobulin M and G titers. The patient responded to oral corticosteroids with signs and symptoms resolving over the course of 3 months' treatment...
December 23, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28006052/association-of-low-vitamin-d-levels-with-noninfectious-anterior-uveitis
#9
Lindsay A Grotting, Samaneh Davoudi, Deanna Palenzuela, George N Papaliodis, Lucia Sobrin
Importance: Vitamin D plays an important role in both the innate and adaptive immune systems. It has been shown to contribute to the etiology of T-cell-mediated autoimmune diseases through the upregulation of type 2 anti-inflammatory T helper cells and the suppression of type 1 T helper cells. Noninfectious uveitis is postulated to be caused by immune dysfunction. Objective: To determine whether there is an association between vitamin D levels and noninfectious anterior uveitis...
December 22, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28005810/a-rare-patient-with-orbital-apex-syndrome-anterior-uveitis-and-necrotizing-scleritis-due-to-herpes-zoster-ophthalmicus
#10
Erdinc Aydin, Melike Balikoglu-Yilmaz, Seher Saritepe Imre, Feray Koc, Levent Kazanci, Arif Taylan Ozturk
The purpose of this study was to describe a patient of orbital apex syndrome, anterior uveitis, secondary glaucoma, corneal dellen, and necrotizing scleritis following an attack of herpes zoster ophthalmicus, and the placement of a pericardial patch graft. A 64-year-old male patient with blepharoptosis of his right eye and multiple vesicles on the forehead, nose and cheeks, limitation on all gazes, blepharoptosis, and exophthalmia was eventually diagnosed with ophthalmic zona with orbital apex syndrome. After the treatment with systemic antiviral and steroid, there was complete recovery of the unilateral vesicular eruption, ophthalmoplegia, and ptosis at the third month follow-up...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28002536/a-case-of-sweet-s-syndrome-associated-with-uveitis-in-a-young-male-with-ulcerative-colitis
#11
Ligia Ariana Bancu, Corina Ureche, Nicoleta Maria Crăciun, Dorin Marian
Sweet's syndrome is rare acute febrile neutrophilic dermatosis whose onset is either idiopathic or associated with other underlying conditions, such as infections, autoimmune diseases, pregnancy, use of certain medications, or malignancy. We report the case of a young male with known history of ulcerative colitis and abrupt onset of high fever, malaise, blurred vision and eruption of painful erythematous nodules and papules, localized on the head, neck, trunk and upper limbs. Ophthalmological examination established the diagnosis of anterior uveitis...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27998698/ocular-complications-in-survivors-of-the-ebola-outbreak-in-guinea
#12
Esther Hereth He'bert, Mamadou Oury Bah, Jean François E'tard, Mamadou Saliou Sow, Serge Resnikoff, Christine Fardeau, Abdoulaye Toure', Alexis Niouma Ouendeno, Isaac Ceougna Sagno, Laura March, Suzanne Izard, Pierre Louis Lama, Moumié Barry, Eric Delaporte
PURPOSE: The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after two negative blood PCR results, face psychosocial disorders, rheumatic, ear-nose-throat, neurocognitive, and ophthalmological complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences...
December 17, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27977029/painful-acute-corneal-ulceration-and-anterior-stromal-keratitis-in-an-adolescent-with-reactive-arthritis
#13
Christopher J Lyons, Elham AlQahtani, Hughie Tsang, Gregory T Moloney, Jane Gardiner
Reactive arthritis is occasionally associated with conjunctivitis and uveitis, but rarely keratitis. The authors describe a patient with paracentral anterior stromal keratitis with overlying epithelial erosion and multiple satellite subepithelial infiltrates. The initial appearance and the severe pain were suggestive of an infectious process. Recovery was rapid following introduction of topical steroid, with features suggesting an immune process in the recovery phase. The authors suggest that a history of arthritis and/or recent enteritis should be sought in the work-up of an atypical keratitis with or without epithelial defect...
December 8, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27965977/lack-of-association-between-genetic-polymorphisms-of-jak-stat-signaling-pathway-genes-and-acute-anterior-uveitis-in-han-chinese
#14
Ling Cheng, Hongsong Yu, Yan Jiang, Juan He, Sisi Pu, Xin Li, Li Zhang
Purpose. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population. Methods. Eleven SNPs of the JAK1, JAK2, STAT1, IRF1, and NOS2 genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls. Genotyping was performed by PCR-RFLP assay or TaqMan® probe assay. The Chi-squared (χ(2)) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27964790/the-eye-and-inflammatory-rheumatic-diseases-the-eye-and-rheumatoid-arthritis-ankylosing-spondylitis-psoriatic-arthritis
#15
REVIEW
Philip Ian Murray, Saaeha Rauz
Rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis are associated with potentially sight-threatening inflammatory eye disease. Although the ocular manifestations associated with ankylosing spondylitis and psoriatic arthritis are similar, such as anterior uveitis, this differs from rheumatoid arthritis where dry eye, peripheral ulcerative keratitis and scleritis are the major ocular complications. Apart from causing sight loss, these conditions are painful, debilitating, often recurrent or chronic and may require long-term therapy...
October 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27959848/-tubulointerstitial-nephritis-syndrome-and-uveitis
#16
Carolina A Isnardi, Andrés Vilela, Pablo Kuschner, Carolina Salvo, Cecilia Vanzetti, Hugo Zelechower, Adriana Arpa
Intermediate uveitis is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. It is a subset of uveitis where the vitreous is the major site of damage. It has been reported to be associated with many local and systemic inflammatory and infectious diseases. An infrequent cause is the tubulointerstitial nephritis and uveitis syndrome. We report a case of an acute visual acuity loss related with renal failure in a 64 years old woman with Hashimoto disease. It was an acute tubulointerstitial nephritis and uveitis syndrome case...
2016: Medicina
https://www.readbyqxmd.com/read/27956325/profile-of-patients-with-uveitis-referred-to-a-multidisciplinary-unit-in-northern-spain
#17
P Fanlo, H Heras, D Pérez, G Tiberio, G Espinosa, A Adan
OBJECTIVE: To describe the main characteristics of a cohort of patients with uveitis referred to a multidisciplinary unit in northern Spain. MATERIAL AND METHODS: Retrospective analysis of clinical records of patients evaluated in the Multidisciplinary Unit of the Navarra Hospital Complex from the period January 2010 until March 2015. An analysis was performed on the demographic characteristics, origin, types of uveitis, laterality, and aetiology. The present series was also compared with 2 previous series from Castilla y León and Barcelona...
December 7, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27937751/failure-to-integrate-quantitative-measurement-methods-of-ocular-inflammation-hampers-clinical-practice-and-trials-on-new-therapies-for-posterior-uveitis
#18
Carl P Herbort, Ilknur Tugal-Tutkun, Piergiorgio Neri, Carlos Pavésio, Sumru Onal, Phuc LeHoang
Uveitis is one of the fields in ophthalmology where a tremendous evolution took place in the past 25 years. Not only did we gain access to more efficient, more targeted, and better tolerated therapies, but also in parallel precise and quantitative measurement methods developed allowing the clinician to evaluate these therapies and adjust therapeutic intervention with a high degree of precision. Objective and quantitative measurement of the global level of intraocular inflammation became possible for most inflammatory diseases with direct or spill-over anterior chamber inflammation, thanks to laser flare photometry...
December 12, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27937076/uveitic-glaucoma-long-term-clinical-outcome-and-risk-factors-for-progression
#19
Yael Sharon, Ronit Friling, Moshe Luski, Belén Quizhpe Campoverde, Radgonde Amer, Michal Kramer
PURPOSE: To study the long-term clinical outcomes of uveitic glaucoma and to identify risk factors for progression. METHODS: Retrospective study of uveitic glaucoma patients in two tertiary medical centers in 2003-2015. Patient- and disease-related data was retrieved. Clinical parameters and visual fields measured at predetermined time points were recorded. Outcome measures included maintaining intraocular pressure ≤21 mmHg and preserving visual fields. RESULTS: Included were 34 patients (53 eyes), with a mean follow-up of 7 years...
December 12, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27937033/epidemiology-of-uveitis-in-a-tertiary-care-referral-institute-in-north-india
#20
Mohit Dogra, Ramandeep Singh, Aniruddha Agarwal, Ashok Sharma, Simar Rajan Singh, Natasha Gautam, Sonam Yangzes, Ramanuj Samanta, Manu Sharma, Kanika Aggarwal, Aman Sharma, Kusum Sharma, Reema Bansal, Amod Gupta, Vishali Gupta
PURPOSE: To report epidemiology of uveitis in a tertiary-care referral institute in North India. METHODS: Hospital records of patients with uveitis between June 2011 and September 2014 were retrospectively analyzed. RESULTS: Of the 1912 patients, 56.64% were males. Anterior uveitis (43.04%) was the most common manifestation followed by posterior uveitis (24.58%), panuveitis (16.21%), and intermediate uveitis (10.66%). Specific etiologies could be ascertained in 60...
December 12, 2016: Ocular Immunology and Inflammation
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