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https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#1
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29681844/topical-corticosteroid-resolved-rubeosis-iridis-with-neovascular-glaucoma-caused-by-noninfectious-granulomatous-uveitis
#2
Daisuke Sora, Kei Takayama, Manzo Taguchi, Tomohito Sato, Yutaka Sakurai, Takayuki Kanda, Masaru Takeuchi
Purpose: We report a case of topical corticosteroid treatment-resolved rubeosis iridis with neovascular glaucoma (NVG) caused by noninfectious granulomatous uveitis. Case Report: A 61-year-old woman with left ocular pain and blurred vision was referred to our department. Visual acuity and intraocular pressure (IOP) were 20/60 and 37 mm Hg in the left eye, respectively. Inflammatory cells, hyphema, and rubeosis iridis were observed. All laboratory tests, including multiplex polymerase chain reaction for infection using aqueous humor, were negative, and there was neither retinal occlusive vasculitis nor retinal ischemia in the fundus...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29675414/spondyloarthritis-acute-anterior-uveitis-and-fungi-updating-the-catterall-king-hypothesis
#3
Martin Laurence, Mark Asquith, James T Rosenbaum
Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of idiopathic chronic inflammation of the spine, joints, eyes, skin, gut, and prostate. Inflammation is often asymptomatic, especially in the gut and prostate. The HLA-B*27 allele group, which presents intracellular peptides to CD8+ T cells, is by far the strongest risk factor for spondyloarthritis. The precise mechanisms and antigens remain unknown. In 1959, Catterall and King advanced a novel hypothesis explaining the etiology of spondyloarthritis: an as-yet-unrecognized sexually acquired microbe would be causing all spondyloarthritis types, including acute anterior uveitis...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29675026/multiplex-cytokine-analysis-of-aqueous-humor-in-juvenile-idiopathic-arthritis-associated-anterior-uveitis-with-or-without-secondary-glaucoma
#4
Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M Koch, Philipp S Müther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten Heinz
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29672247/management-of-chronic-hypotony-following-bilateral-uveitis-in-a-patient-treated-with-pembrolizumab-for-cutaneous-metastatic-melanoma
#5
Gerard Reid, Paul Lorigan, Heinrich Heimann, Marta Hovan
PURPOSE: To describe the presentation and management of severe ocular adverse events following treatment with pembrolizumab for cutaneous metastatic melanoma. METHODS: Interventional case report. RESULTS: A 73-year-old Caucasian man receiving pembrolizumab treatment for metastatic melanoma presented with panuveitis and subsequent profound hypotony, choroidal effusions, and optic disk swelling bilaterally. Oral prednisolone controlled intraocular inflammation...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29670780/syphilis-related-eye-disease-presenting-as-bilateral-papilledema-retinal-nerve-fiber-layer-hemorrhage-and-anterior-uveitis-in-a-penicillin-allergic-patient
#6
Jamie Dietze, Shane Havens
Purpose . Treponema pallidum is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Human immunodeficiency virus (HIV) is known to expedite the progression of syphilis when patients are coinfected, thus compounding the potential ophthalmic presentations...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29666122/iontophoretic-delivery-of-dexamethasone-phosphate-for-non-infectious-non-necrotising-anterior-scleritis-dose-finding-clinical-trial
#7
Erin C O'Neil, Jiayan Huang, Eric B Suhler, James P Dunn, Victor L Perez, David C Gritz, Kathy McWilliams, Ellen Peskin, Gui-Shuang Ying, Vatinee Y Bunya, Maureen G Maguire, John H Kempen
Currently available treatment options for non-infectious scleritis, including non-steroidal anti-inflammatory drugs, systemic corticosteroids and immunosuppressive therapies, have both efficacy and side effect limitations. Iontophoretic delivery of corticosteroids has been demonstrated to be effective for anterior uveitis and represents a potential new approach to scleritis therapy. We hypothesised that iontophoretic delivery would provide effective and precise medication delivery to the sclera, while limiting systemic exposure and side effects...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29663152/a-glimpse-into-uveitis-in-the-aging-eye-pathophysiology-clinical-presentation-and-treatment-considerations
#8
REVIEW
Elizabeth Akinsoji, Raquel Goldhardt, Anat Galor
Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Some causes of uveitis in the elderly are herpes simplex virus, ocular ischemic syndrome, sarcoidosis, and central nervous system lymphoma, and these will be discussed in detail herein...
April 16, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#9
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 13, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29652210/idiopathic-central-nervous-system-inflammatory-disease-in-the-setting-of-hla-b27-uveitis
#10
Eric L Crowell, Margaret L Pfeiffer, Ankur A Kamdar, Mary K Koenig, Susan E Wittenberg, Emilio P Supsupin, Ore-Ofe O Adesina
PURPOSE: The purpose of the article is to describe a novel case of idiopathic central nervous system inflammatory disease with bilateral human leukocyte antigen (HLA)-B27-positive anterior uveitis. METHODS/RESULTS: A 15-year-old African American boy with bilateral HLA-B27-positive anterior uveitis controlled with topical and oral steroids for 8 months acutely developed headaches, left eyelid ptosis, and binocular diplopia. Imaging showed lesions in the right midbrain, superior colliculus, cerebellar peduncles, and cerebellar vermis and leptomeningeal enhancement along the vermian foliae...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29625716/-ocular-manifestations-in-beh%C3%A3-et-s-disease
#11
A-C Desbois, C Terrada, P Cacoub, B Bodaghi, D Saadoun
Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. The risk of blindness at 5 years is in the order of 15 to 25%, mainly due to macular involvement or retinal vasculitis. Uveitis may be anterior, intermediate, posterior or panuveitis...
April 3, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29625474/gut-microbiota-composition-and-fecal-metabolic-phenotype-in-patients-with-acute-anterior-uveitis
#12
Xinyue Huang, Zi Ye, Qingfeng Cao, Guannan Su, Qingfeng Wang, Jing Deng, Chunjiang Zhou, Aize Kijlstra, Peizeng Yang
Purpose: To investigate gut microbiota composition and fecal metabolic phenotype in patients with acute anterior uveitis. Methods: Fecal DNA was extracted from 78 fecal samples (38 acute anterior uveitis (AAU) patients and 40 family members of patients or sex- and age-matched healthy controls) and then sequenced by high-throughput 16S rDNA analysis. Gas chromatographic mass spectrometry (GC-MS) based metabolomics was performed on 60 fecal samples (30 AAU patients and 30 healthy controls)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623252/intraocular-inflammation-in-a-case-of-bee-sting-injury
#13
Ekta Rishi, Pukhraj Rishi
A19-year-old man presented with decreased vision in the right eye following a bee sting injury, ten days back. Examination revealed conjunctival hyperemia at the site of the sting, anterior uveitis, vitritis, mild disc hyperemia, ocular hypotony, and striae at macula. Treatment was initiated elsewhere with topical antibiotics, steroid, and cycloplegic. Systemic steroids were added. Three weeks later, vitiritis resolved, intraocular pressure became normal and the vision improved from 20/60 to 20/20. However, a chorioretinal atrophy in the vicinity of the sting site was noted...
2018: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#14
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29620146/a-study-of-the-key-genes-and-inflammatory-signaling-pathways-involved-in-hla-b27-associated-acute-anterior-uveitis-families
#15
Shuo Yu, Cui Mao, Jinyi Yu, Xin Qi, Jing Wang, Hong Lu
The present study was conducted to investigate the key genes and the inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis (AAU) families. Four families with HLA-B27‑positive aau patients and their HLA-B27-positive blood relatives were included in the study. peripheral blood monocytes were isolated from the subjects and stimulated by lipopolysaccharides (LPS). Gene expression microarrays were used to identify the differentially expressed genes (DEGs), and the DEGs were analyzed by a range of bioinformatics-based techniques, including Gene Ontology (GO), Pathway analysis, Signal-Net analysis and Gene Relation Network (Gene-Rel-Net)...
March 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29610003/-therapeutic-strategy-for-the-treatment-of-non-infectious-uveitis-proposed-by-an-expert-panel
#16
E Diwo, P Sève, S Trad, P Bielefeld, D Sène, S Abad, A Brézin, P Quartier, I Koné Paut, M Weber, C Chiquet, M H Errera, J Sellam, P Cacoub, G Kaplanski, L Kodjikian, B Bodaghi, D Saadoun
Conventional immunosuppressive drugs, anti-TNF alpha and other biotherapies used in clinical practice are capable of controlling non-infectious anterior uveitis, posterior uveitis and panuveitis. The present work has been led by a multidisciplinary panel of experts, internists, rheumatologists and ophthalmologists and is based on a review of the literature. In case of corticodependency or sight-threatening disease, conventional immunosuppressive drugs (methotrexate, azathioprine and mycophenolate mofetil) and/or anti-TNF alpha (adalimumab, infliximab) are used to achieve and maintain remission...
March 30, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29602570/successful-optimization-of-adalimumab-therapy-in-refractory-uveitis-due-to-beh%C3%A3-et-s-disease
#17
José Luis Martín-Varillas, Vanesa Calvo-Río, Emma Beltrán, Juan Sánchez-Bursón, Marina Mesquida, Alfredo Adán, María Victoria Hernandez, Marisa Hernández Garfella, Elia Valls Pascual, Lucía Martínez-Costa, Agustí Sellas-Fernández, Miguel Cordero-Coma, Manuel Díaz-Llopis, Roberto Gallego, David Salom, Norberto Ortego, José L García-Serrano, José-Luis Callejas-Rubio, José M Herreras, Ángel García-Aparicio, Olga Maíz, Ana Blanco, Ignacio Torre, David Díaz-Valle, Esperanza Pato, Elena Aurrecoechea, Miguel A Caracuel, Fernando Gamero, Enrique Minguez, Carmen Carrasco-Cubero, Alejandro Olive, Julio Vázquez, Oscar Ruiz-Moreno, Javier Manero, Santiago Muñoz-Fernández, Myriam Gandía Martinez, Esteban Rubio-Romero, F Javier Toyos-Sáenz de Miera, Francisco Javier López Longo, Joan M Nolla, Marcelino Revenga, Carmen González-Vela, Javier Loricera, Belén Atienza-Mateo, Rosalía Demetrio-Pablo, José Luis Hernández, Miguel A González-Gay, Ricardo Blanco
PURPOSE: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months...
March 27, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29601822/pars-plana-vitrectomy-for-the-treatment-of-uveitis
#18
Christopher R Henry, Matthias D Becker, Yongsheng Yang, Janet L Davis
PURPOSE: To review and summarize evidence in the medical literature in regards to the use of pars plana vitrectomy in the management of uveitis. DESIGN: Systematic literature review METHODS: A systematic literature search was conducted for relevant articles on pars plana vitrectomy for the management of uveitis. Results from the studies were compiled and analyzed. RESULTS: Thirty-four articles, published from 2005 through 2014, were included in the final data analysis...
March 27, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29601821/chronic-anterior-uveitis-in-children-psychosocial-challenges-for-patients-and-their-families
#19
Delana M Parker, Sheila T Angeles-Han, Annette L Stanton, Gary N Holland
PURPOSE: To describe issues of concern to children with chronic anterior uveitis; to consider the psychological impact of chronic anterior uveitis on children's lives; and to understand the effect of a child's chronic illness on other family members. DESIGN: Expert commentary. METHODS: Author experiences were supplemented by a review of pertinent medical literature and by consideration of content from semi-structured, separate patient and parent interviews...
March 27, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29590655/lipocalin-2-suppresses-ocular-inflammation-by-inhibiting-the-activation-of-nf-%C3%AE%C2%BA%C3%AE-pathway-in-endotoxin-induced-uveitis
#20
Wenyi Tang, Jun Ma, Ruiping Gu, Xinyi Ding, Boya Lei, Xin Wang, Hong Zhuang, Gezhi Xu
BACKGROUND/AIMS: Lipocalin 2 (LCN2), an important mediator of a variety of cellular processes, is involved in regulating the inflammatory response, but its roles in different inflammatory diseases are controversial. Because the role of LCN2 in ocular inflammation has been unclear until now, we explored the function of LCN2 in lipopolysaccharide (LPS)-induced ocular inflammation in vivo and in vitro. METHODS: Endotoxin-induced uveitis (EIU) was induced in male Sprague Dawley rats by the intravitreal injection of LPS...
March 23, 2018: Cellular Physiology and Biochemistry
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