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Anterior Uveitis

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https://www.readbyqxmd.com/read/29429764/safety-and-efficacy-of-adalimumab-in-patients-with-noninfectious-uveitis-in-an-ongoing-open-label-study-visual-iii
#1
Eric B Suhler, Alfredo Adán, Antoine P Brézin, Eric Fortin, Hiroshi Goto, Glenn J Jaffe, Toshikatsu Kaburaki, Michal Kramer, Lyndell L Lim, Cristina Muccioli, Quan Dong Nguyen, Joachim Van Calster, Luca Cimino, Martina Kron, Alexandra P Song, Jianzhong Liu, Sophia Pathai, Anne Camez, Ariel Schlaen, Mirjam E J van Velthoven, Albert T Vitale, Manfred Zierhut, Samir Tari, Andrew D Dick
PURPOSE: To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Phase 3, open-label, multicenter clinical trial extension (VISUAL III). PARTICIPANTS: Adults meeting treatment failure (TF) criteria or who completed VISUAL I or II (phase 3, randomized, double-masked, placebo-controlled) without TF. METHODS: Patients received adalimumab 40 mg every other week...
February 8, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29427823/contribution-of-diagnostic-tests-for-the-etiological-assessment-of-uveitis-data-from-the-ulisse-study-uveitis-clinical-and-medicoeconomic-evaluation-of-a-standardized-strategy-of-the-etiological-diagnosis
#2
REVIEW
Pierre Grumet, Laurent Kodjikian, Audrey de Parisot, Marie-Hélène Errera, Neila Sedira, Emmanuel Heron, Laurent Pérard, Pierre-Loïc Cornut, Christelle Schneider, Sophie Rivière, Priscille Ollé, Grégory Pugnet, Pascal Cathébras, Pierre Manoli, Bahram Bodaghi, David Saadoun, Stéphanie Baillif, Nathalie Tieulie, Marc Andre, Frédéric Chiambaretta, Nicolas Bonin, Philip Bielefeld, Alain Bron, Frédéric Mouriaux, Boris Bienvenu, Stéphanie Vicente, Sylvie Bin, Marc Labetoulle, Christiane Broussolle, Yvan Jamilloux, Evelyne Decullier, Pascal Sève
PURPOSE: ULISSE is the only study that prospectively assessed the efficiency of a standardized strategy, compared to an open strategy for the etiologic diagnosis of uveitis. Our aim was to evaluate the diagnostic yield of the tests prescribed in the ULISSE study to clarify their relevance. METHODS: ULISSE is a non-inferiority, prospective, multicenter and cluster randomized study. The standardized strategy is a two-steps strategy: in the first step, common standard tests were performed, and in the second step, tests were guided by the clinical and anatomic type of uveitis...
February 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29426968/clinical-experience-with-urgent-tube-shunt-implantation-through-the-ciliary-sulcus-in-phakic-eyes
#3
Adam J Weiner, Yotam Weiner, Melissa L Severson, Asher Weiner
PURPOSE: To review the clinical course and outcomes of 3 phakic, ischemic, and inflamed eyes in which we performed urgent tube shunt implantation through the ciliary sulcus without lensectomy. METHODS: This is a retrospective interventional case series. Three eyes of 3 diabetic patients with uncontrolled severe neovascular glaucoma, shallow anterior chambers with closed angles and poor view to the posterior segment, where concomitant lensectomy was not recommended due to uncontrolled uveitis and ischemia, underwent tube shunt implantation through the ciliary sulcus...
February 9, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29424312/association-of-il33-and-il1rap-polymorphisms-with-acute-anterior-uveitis
#4
X F Huang, W Chi, D Lin, M L Dai, Y L Wang, Y M Yang, Z B Jin, Y Wang
AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system. In the present study, we investigated the association of IL33 and IL1RAP genes with AAU. A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology. Our findings demonstrated that IL1RAP-rs3773978 significantly associated with AAU and could serve as a genetic risk marker in Chinese AAU patients...
February 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29424310/elevated-interleukin-37-expression-associated-with-disease-activity-in-hla-b27-associated-anterior-uveitis-and-idiopathic-anterior-uveitis
#5
B Zhao, S Zhang, W Chen, R Zhang, R Jiang, R Zhang, L Chen
BACKGROUND & OBJECTIVE: Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS: 15 patients with HLA-B27-associated AAU, 10 patients with idiopathic AAU and 22 controls were recruited to this study from August 2013 to December 2016...
February 7, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29420114/role-of-ct-chest-and-cytology-in-differentiating-tuberculosis-from-presumed-sarcoidosis-in-uveitis
#6
Reema Bansal, Amod Gupta, Ritesh Agarwal, Mohit Dogra, Garvit Bhutani, Vishali Gupta, M R Dogra, Deeksha Katoch, Ashutosh Nath Aggarwal, Aman Sharma, Raje Nijhawan, Ritambara Nada, Uma Nahar Saikia, Pranab Dey, Digambar Behera
PURPOSE: To report the role of CT chest and cytology in suspected tubercular and sarcoid uveitis. METHODS: This is a retrospective, interventional case series of 376 uveitis patients with suspected ocular tuberculosis (TB)/sarcoidosis seen between January 2010 and April 2015 at the Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. All underwent CT chest, and had following inclusion criteria: (1) Presence of active granulomatous anterior/intermediate/posterior uveitis or panuveitis; (2) a documented tuberculin skin test/QuantiFERON-TB Gold test; (3) all other causes of infectious/non-infectious uveitis ruled out...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29420111/increased-aqueous-humor-cd4-cd8-lymphocyte-ratio-in-sarcoid-uveitis
#7
Namita Dave, Priyanka Chevour, Padmamalini Mahendradas, Anitha Venkatesh, Ankush Kawali, Rohit Shetty, Arkasubhra Ghosh, Swaminathan Sethu
PURPOSE: To determine aqueous humor CD4+/CD8+ T-lymphocyte ratio changes in sarcoid and non-sarcoid uveitis with anterior chamber involvement. METHODS: The case-control study includes 61 patients with either anterior uveitis, intermediate uveitis with anterior spill, or panuveitis. A total of 21 of them were categorized as sarcoid uveitis and 40 as non-sarcoid uveitis according to diagnostic criteria. CD4+/CD8+ ratio in the aqueous humor was determined using flow cytometry...
February 8, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29419907/granulomatous-tattoo-reaction-with-associated-uveitis-successfully-treated-with-methotrexate
#8
K I Maijer, S A S van der Bent, W Vercoutere, T Rustemeyer
Few reports describe tattoo granulomas with the simultaneous development of intraocular inflammation without any evidence of systemic sarcoidosis at the time of presentation. Here, we present a patient with no prior diagnosis of sarcoidosis who developed inflammation of tattooed skin and shortly after bilateral uveitis.A 52-year-old previously healthy woman presented with a 8 months history of swelling and itching located in all of her 11 black tattoos. Approximately 5 months later she developed complaints of blurred vision, diagnosed as recurrent uveitis anterior by an ophthalmologist...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29415753/recurrent-anterior-uveitis-and-subsequent-incidence-of-ankylosing-spondylitis-a-nationwide-cohort-study-from-2002-to-2013
#9
Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee, Hyeong Gon Yu
BACKGROUND: Anterior uveitis is the most common extra-articular manifestation of ankylosing spondylitis (AS). AS-related anterior uveitis frequently presents as acute, recurrent iridocyclitis; therefore, AS is often initially suspected by an ophthalmologist, not by a rheumatologist. In this study, we aimed to investigate the relationship between the recurrence of anterior uveitis and the subsequent incidence of AS. METHODS: From a national sample cohort, 10,483 patients with new-onset uveitis between 2004 and 2013 and 52415 matched control subjects who had never experienced uveitis were selected...
February 7, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29398234/bilateral-acute-iris-transillumination-syndrome-a-case-report
#10
P Plaza-Ramos, H Heras-Mulero, P Fanlo, A Zubicoa
OBJECTIVE: To present a case report of a patient with a bilateral acute iris transillumination syndrome (BAIT). METHODS: BAIT syndrome is a new clinical condition characterised by severe transillumination of the iris, acute onset of pigment dispersion in the anterior chamber, and a medial mydriatic pupil that is unresponsive or poorly responsive to light, due to a sphincter paralysis. Patients with BAIT generally present with acute ocular pain, photophobia, and red eyes...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29395599/-anterior-uveitis
#11
REVIEW
J Gueudry, M Muraine
Anterior uveitis is the most common form of uveitis. There are several known and many possible etiologies for anterior uveitis. After examining the posterior segment and ruling out masquerade syndromes, the main step of etiologic diagnosis is clinical characterization. It is essential to establish unilateral versus bilateral involvement and presence or absence of granulomatous features. Subsequently, a work-up may be obtained which then helps to confirm diagnostic hypotheses based on the detailed history and clinical examination...
January 29, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29394206/secondary-glaucoma-due-to-iridescent-crystalline-particles-masquerading-as-refractory-hypertensive-uveitis-in-an-eye-with-irradiated-iris-melanoma
#12
Rupinder Chahal, Abhijit Anand Mohite, Heinrich Heimann, Atul Bansal
PURPOSE: We report a previously unrecognised mechanism of secondary glaucoma due to iridescent crystalline particles released from an irradiated iris melanoma. It masqueraded as refractory hypertensive uveitis following uncomplicated phacoemulsification. METHODS: A 58-year-old gentleman had an iris melanoma that underwent successful regression following irradiation with proton beam radiotherapy (PBRT). Three years later an uncomplicated phacoemulsification with intraocular lens implant was performed and subsequently the patient presented with apparently "refractory hypertensive uveitis"...
February 1, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29392512/different-ethnic-background-is-associated-with-distinct-clinical-profiles-in-the-spondyloarthritides-in-the-north-and-south-of-brazil
#13
Sandra Lúcia Euzébio Ribeiro, Ana Paula Beckhauser de Campos, Penélope Esther Palominos, Adriana Bruscato Bortoluzzo, Marta Aline Coelho da Costa, Talita de Oliveira Ribeiro, Percival Degrava Sampaio-Barros
The objective of this study was to analyze the clinical profile of the spondyloarthritides (SpA) in distinct Brazilian regions. A common protocol of investigation was prospectively applied to 202 SpA patients, including 138 patients from the South and 64 patients from the North. All the patients were classified as axial or peripheral SpA. Clinical and demographic variables and disease indexes were analyzed. Bonferroni correction was used to adjust the level of significance of each test; results with p value < 0...
February 1, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29380792/systemic-diffuse-large-b-cell-lymphoma-masquerading-as-neovascular-glaucoma
#14
Pritam Bawankar, Dipankar Das, Harsha Bhattacharjee, Shahinur Tayab, Nilutparna Deori, Vivek Paulbuddhe, Shriya Dhar, Apurba Deka
We describe a case of spontaneous hyphema associated with anterior uveitis presents in a 69-year old female as the prominent sign of the intraocular spread of systemic diffuse large B-cell lymphoma (DLBCL). She had a history of diabetes and initially misdiagnosed as neovascular glaucoma. Clinical history of systemic lymphoma, characteristic findings on B-scan ultrasonography and magnetic resonance imaging scan, and identification of atypical lymphoid cells in aqueous sample established the diagnosis of intraocular metastasis of systemic DLBCL...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29378727/prevalence-and-characteristics-of-ocular-pain-in-non-infectious-uveitis-a-quality-of-life-study
#15
Fleurieke H Verhagen, Ralph Wijnhoven, Jeannette Ossewaarde-van Norel, Ninette H Ten Dam-van Loon, Jonas J W Kuiper, Saskia M Imhof, Joke H de Boer
BACKGROUND/AIM: To survey the frequency, character, severity and impact of ocular pain on quality of life in adult patients with non-infectious uveitis (NIU). METHODS: This patient-requested cross-sectional survey study describes the results of three self-administered questionnaires (the National Eye Institute Visual Function Questionnaire, the 36-Item Short Form Health Survey (SF-36) and the McGill Pain Questionnaire Dutch Language Version) from 147 patients with NIUs from a university-based tertiary referral centre in Utrecht...
January 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29377953/intra-cameral-level-of-ganciclovir-gel-0-15-following-topical-application-for-cytomegalovirus-anterior-segment-infection-a-pilot-study
#16
Samanthila Waduthantri, Lei Zhou, Soon-Phaik Chee
PURPOSE: To investigate the intra-cameral level of ganciclovir following topical application of ganciclovir gel, 0.15% for cytomegalovirus (CMV) anterior segment infection. DESIGN: Non-randomized, prospective, interventional clinical study. METHODS: Patients with active CMV anterior segment infection seen at Singapore National Eye Centre, confirmed by positive CMV real time PCR (RT-PCR) of the aqueous humor, that had not been treated with any form of ganciclovir in the preceding 1 month were recruited...
2018: PloS One
https://www.readbyqxmd.com/read/29377783/diagnosis-of-cytomegalovirus-anterior-uveitis-in-two-european-referral-centers
#17
Lia Judice M Relvas, Joelle Antoun, Jolanda D F de Groot-Mijnes, Elie Motulsky, Ninette H Ten Dam-Van Loon, Dorine Makhoul, François Willermain, Laure Caspers
PURPOSE: To evaluate diagnostic methods and clinical signs of CMV anterior uveitis (AU), a rarely described entity in Europe. METHODS: We included patients with clinical characteristics of CMV AU and positive PCR and/or Goldmann-Witmer coefficient (GWc) for CMV. RESULTS: We report 21 patients with unilateral uveitis (100%) and signs of Posner-Schlossman syndrome (PSS) (n = 20, 95.2%), Fuchs uveitis syndrome (FUS) (n = 1, 4.7%), and endotheliitis (n = 4, 19,04%)...
2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29370567/complications-in-intermediate-uveitis-prevalence-time-of-onset-and-effects-on-vision-in-short-term-and-long-term-follow-up
#18
Ligia Sancho, Michal Kramer, Adi Koriat, Maya Eiger-Moscovich, Yael Sharon, Radgonde Amer
PURPOSE: To study the prevalence and time of onset of ocular complications in intermediate uveitis (IU) and to assess their effects on visual outcome in short-term and long-term follow-up. METHODS: A retrospective cohort study of patients with IU who had a minimal follow-up of one year. RESULTS: 96 patients (174 eyes, 70% females) were included with a mean age at presentation of 30 years. Children constituted 38% of all patients. Mean follow- up was 64...
January 25, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29370565/clinical-profile-of-scleritis-in-children
#19
Parthopratim Dutta Majumder, Sowkath Ali, Amala George, Sudha Ganesh, Jyotirmay Biswas
PURPOSE: To describe the clinical pattern of scleritis in patients ≤16 years of age at a tertiary care eye hospital in India. METHODS: The medical records of 24 eyes of 20 children with scleritis were included in this retrospective study. Collected data included age, subsets of uveitis, best corrected visual acuities (BCVA), detailed laboratory investigations and treatment. RESULTS: Mean age at presentation was 12.2 ± 2.5 years. Scleritis was unilateral in 80% patients and an equal gender distribution was observed...
January 25, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29360007/could-be-serum-uric-acid-a-risk-factor-for-thrombosis-and-or-uveitis-in-behcet-s-disease
#20
Avcı Atıl, Avcı Deniz
Introduction Serum uric acid level increases in many inflammatory conditions. Uric acid triggers the vascular inflammation and artery damage, which causes to an increased risk of endothelial dysfunction and atherosclerosis. It is not clear in the literature whether uric acid contributes to uveitis by similar mechanisms. We investigated whether uric acid level increases in Behcet's disease patients with thrombosis or anterior uveitis. Patients and methods We reviewed the medical records of 914 Behcet's disease...
January 1, 2018: Vascular
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