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Uveitis anterior

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https://www.readbyqxmd.com/read/28706771/an-unusual-case-of-bilateral-anterior-uveitis-related-to-moxifloxacin-the-first-report-in-latin-america
#1
Carlos M Rangel, M Margarita Parra, Gabriel Frederick, Alejandro Tello, Clara L Varón
Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods: Case report. Results: A 54-year-old female presented bilateral anterior uveitis following a 10-day course of oral moxifloxacin. She developed a bilateral anterior uveitis associated with pigment dispersion syndrome and iris transillumination. Conclusions: Drug-induced uveitis is one of the causes of anterior uveitis. Uveitis related to fluoroquinolones is a rare entity, there are few cases reported in the literature, this is the first case reported in Latin America...
2017: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/28706439/genome-wide-retinal-transcriptome-analysis-of-endotoxin-induced-uveitis-in-mice-with-next-generation-sequencing
#2
Yiguo Qiu, Peng Yu, Ru Lin, Xinyu Fu, Bingtao Hao, Bo Lei
PURPOSE: Endotoxin-induced uveitis (EIU) is a well-established mouse model for studying human acute inflammatory uveitis. The purpose of this study is to investigate the genome-wide retinal transcriptome profile of EIU. METHODS: The anterior segment of the mice was examined with a slit-lamp, and clinical scores were evaluated simultaneously. The histological changes in the posterior segment of the eyes were evaluated with hematoxylin and eosin (H&E) staining. A high throughput RNA sequencing (RNA-seq) strategy using the Illumina Hiseq 2500 platform was applied to characterize the retinal transcriptome profile from lipopolysaccharide (LPS)-treated and untreated mice...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28696173/multimodal-imaging-in-anterior-uveitis
#3
Jay Siak, Padmamalini Mahendradas, Soon-Phaik Chee
Anterior uveitis is the most common group of uveitis worldwide, with a diverse spectrum ranging from autoimmune and infectious to masquerade etiologies. Elucidation of the underlying etiology may be challenging, but it remains important, especially for recurrent uveitis. Multimodal imaging has improved our understanding and management of many posterior uveitis and panuveitis. Similarly, a wide variety of anterior segment ophthalmic imaging techniques are available to allow the monitoring of the structural changes that may develop during anterior uveitis...
June 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28690751/-ocular-beh%C3%A3-et
#4
Ahmed Alami, Mohamed Kriet, Karim Reda, Abdelkader Laktaoui, Abdelbaare Oubaaz
Our study aimed to determine the clinical, therapeutic and prognostic features of ocular involvement in patients with Behçet's disease treated in our Department of ophthalmology. We conducted a retrospective data collection from medical records of 20 patients treated at the military hospital in Laayoune. All patients underwent complete ophthalmological examination and fluorescein angiography if necessary. OCT exam was performed in two patients. Ten patients had anterior uveitis, complicated in one case by ocular hypertonia; two patients had intermediate uveitis; eight patients had posterior segment involvement complicated in one case by intravitreal hemorrhage...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28682112/etanercept-for-treating-axial-spondyloarthritis
#5
Xavier Guillot, Clément Prati, Maxime Sondag, Daniel Wendling
Axial spondyloarthritis is an inflammatory rheumatic disease causing back pain, functional impairment and potential ankylosis in the advanced stage. In this context, TNF blockers have been a major therapeutic advance. Etanercept is a soluble recombinant TNF receptor fusion protein in this vain. Areas covered: The aim of this review is to summarize the current published data concerning the efficacy and tolerance of etanercept in axial spondyloarthrits. The authors performed a systematic review on PubMed, using 'etanercept' and 'spondyloarthritis', 'axial spondyloarthritis' or 'ankylosing spondylitis' keywords...
July 6, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28670710/non-steroidal-anti-inflammatory-drugs-versus-corticosteroids-for-controlling-inflammation-after-uncomplicated-cataract-surgery
#6
REVIEW
Viral V Juthani, Elizabeth Clearfield, Roy S Chuck
BACKGROUND: Cataract is a leading cause of blindness worldwide. Cataract surgery is commonly performed but can result in postoperative inflammation of the eye. Inadequately controlled inflammation increases the risk of complications. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are used to prevent and reduce inflammation following cataract surgery, but these two drug classes work by different mechanisms. Corticosteroids are effective, but NSAIDs may provide an additional benefit to reduce inflammation when given in combination with corticosteroids...
July 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28668811/the-effect-of-anterior-uveitis-and-previously-undiagnosed-spondyloarthritis-results-from-the-duet-cohort
#7
Michael O'Rourke, Muhammad Haroon, Salman Alfarasy, Pathma Ramasamy, Oliver FitzGerald, Conor C Murphy
OBJECTIVE: Anterior uveitis (AU) is an intraocular inflammatory condition closely linked to spondyloarthritis (SpA). Clinical disease variables may often underestimate the true effect of the disease on patient's quality of life. This study examines AU and associated undiagnosed SpA using established quality-of-life tools to inform clinicians of the effect of these diseases. METHODS: The Dublin Uveitis Evaluation Tool (DUET) algorithm was developed and validated in a cohort of consecutive patients with AU who were all screened by a rheumatologist for the presence of SpA...
July 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28666730/risk-factors-for-secondary-glaucoma-in-herpetic-anterior-uveitis
#8
Lisette Hoeksema, Nomdo M Jansonius, Leonoor I Los
PURPOSE: To determine the incidence of elevated intraocular pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), due to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma. DESIGN: Retrospective, observational cohort study. METHODS: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included...
June 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28665743/polymerase-chain-reaction-and-its-correlation-with-clinical-features-and-treatment-response-in-tubercular-uveitis
#9
Sudheer Bhagya, Prajna Lalitha, Arya Lalan Kumar, Sivakumar Rathinam
PURPOSE: Correlation of results of polymerase chain reaction for Mycobacterium tuberculosis (MTB PCR) with clinical features and treatment response in tubercular uveitis. METHODS: Retrospective case study. RESULTS: Among 56 patients, 31 (55.3%) had acute and 25 (44.6%) had chronic uveitis. Uveitis was unilateral in 40 (71.4%) and bilateral in the remaining 16 (28.6%). Anatomical subtypes of uveitis were: anterior in 10 (13.9%) eyes, intermediate in 9 (12...
June 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28658315/choroidal-change-in-acute-anterior-uveitis-associated-with-human-leukocyte-antigen-b27
#10
Seong Joon Ahn, Ji Hong Kim, Byung Ro Lee
PURPOSE: To evaluate choroidal changes in eyes with acute anterior uveitis associated with human leukocyte antigen (HLA)-B27. METHODS: In 44 patients with first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which diagnostic work-ups revealed positivity only for HLA-B27, wide-field three-dimensional volumetric raster scan using swept-source optical coherence tomography was performed for both eyes. Choroidal thickness was measured by automated segmentation and thickness mapping and compared between eyes with uveitis and the fellow eyes at baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28655060/biomarkers-and-surrogate-endpoints-in-uveitis-the-impact-of-quantitative-imaging
#11
REVIEW
Alastair K Denniston, Pearse A Keane, Sunil K Srivastava
Purpose: Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis and measurement algorithms across both standard and emerging imaging modalities, can develop objective instrument-based measures of disease activity. Methods: This is a narrative review based on searches of the current world literature using terms related to quantitative imaging techniques in uveitis, supplemented by clinical trial registry data, and expert knowledge of surrogate endpoints and outcome measures in ophthalmology...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28652692/combined-30-degree-bevel-up-and-down-technique-against-0-degree-phaco-tip-for-phacoemulsification-surgery-of-hard-cataracts
#12
Rajesh Subhash Joshi, Sonal Jayant Muley
PURPOSE: To evaluate the effective phaco time (EPT), cumulative dissipated energy (CDE) and nucleus emulsification time (NET) as phaco parameters with 0- and 30-degree phaco tip. PATIENTS AND METHODS: This prospective, interventional and observational case series included 294 patients scheduled for cataract removal by phacoemulsification technique. Patients with nuclear cataracts of grade 4 and 5 nuclear opalescence of Lens Opacities Classification System III were included in the study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28645328/ocular-manifestations-as-first-signs-of-systemic-t-cell-lymphoma-in-two-cases
#13
Xiao Zhang, Xin-Shu Liu, Chan Zhao, Ya-Min Lai, Mei-Fen Zhang
BACKGROUND: Intraocular involvement of systemic T-cell lymphomas are uncommon and have been broadly regarded as markers of poor prognosis. We reported two cases of uveitis patients finally diagnosed as systemic T cell lymphoma. CASE PRESENTATION: Case one is a 19-year-old female presented with fever and liver dysfunction, and was diagnosed as EBV-associated chronic active hepatitis. Fourteen months later, she suffered from recurrent granulomatous anterior uveitis in both eyes, which failed to respond to steroid and immunosuppressant therapy...
June 23, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28630794/a-case-of-presumed-tuberculosis-uveitis-with-occlusive-vasculitis-from-an-endemic-region
#14
Berna Başarır, Yalçın Karaküçük, Çiğdem Altan, Banu Şatana, Bulut Ocak, Aslı İnal
In this report, we present a case with presumed unilateral tuberculosis uveitis from an endemic region. A 23-year-old male presented with decreased vision in his left eye for 15 days. Visual acuities were 1.0 in his right eye and 0.3 in his left eye. Ophthalmologic examination was normal for the right eye. Slit-lamp examination revealed 2+ cells in the vitreous without anterior chamber reaction in his left eye. Fundus examination revealed occlusive vasculitis and granuloma. His history revealed that he had a respiratory infection with fever 3 months ago while visiting his native country, Rwanda, and was treated with non-specific antibiotic therapy...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28630786/ophthoselfie-detailed-self-imaging-of-cornea-and-anterior-segment-by-smartphone
#15
Abdullah Kaya
OBJECTIVES: To describe the ophthoselfie, a method by which everyone can take detailed self-images of the cornea and anterior segment with a smartphone. MATERIALS AND METHODS: A 90-diopter non-contact double aspheric lens was attached to posterior camera of the smartphone by clear tape. Images of one eye on the screen of the smartphone could be seen with the other eye in the mirror and images were taken. RESULTS: Accurate and detailed images of the cornea and anterior segment of the eye could be taken...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28625685/objective-quantification-of-anterior-chamber-inflammation-measuring-cells-and-flare-by-anterior-segment-optical-coherence-tomography
#16
Alessandro Invernizzi, Sylvia Marchi, Raffaella Aldigeri, Valentina Mastrofilippo, Fabiana Viscogliosi, Annamaria Soldani, Chantal Adani, Elena Garoli, Francesco Viola, Luigi Fontana, Peter McCluskey, Luca Cimino
PURPOSE: To assess the ability of swept-source (SS) optical coherence tomography (OCT) of the anterior segment (AS) to measure anterior chamber (AC) inflammation (both flare and cells) objectively. To compare OCT-derived inflammatory indices with standard techniques. DESIGN: Prospective evaluation of a diagnostic test. PARTICIPANTS: Patients diagnosed with anterior uveitis (active or inactive) and controls. METHODS: Participants underwent an AC inflammation evaluation including: clinical cell and flare grading and laser flare photometry (LFP)...
June 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28619012/genetic-analysis-of-varicella-zoster-virus-in-the-aqueous-humor-in-uveitis-with-severe-hyphema
#17
Mayumi Hosogai, Yoko Nakatani, Kensuke Mimura, Shoji Kishi, Hideo Akiyama
BACKGROUND: Genetic variations have been identified in the genome of varicella-zoster virus (VZV) strains using vesicle fluid, varicella scabs and throat swab samples. We report a rare case of VZV-associated uveitis with severe hyphema, which was immediately diagnosed by polymerase chain reaction (PCR) using the aqueous humor, in which we were able to analyze the VZV genotype for the first time. CASE PRESENTATION: A 16-year-old Japanese boy was referred to our hospital with a 20-day history of unilateral anterior uveitis and 11-day history of hyphema...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28607176/clinical-features-of-hla-b27-positive-acute-anterior-uveitis-with-or-without-ankylosing-spondylitis-in-a-chinese-cohort
#18
Peizeng Yang, Wenjuan Wan, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Chaokui Wang, Lili Wu, Aize Kijlstra
AIMS: To characterise the clinical features of human leucocyte antigen (HLA)-B27(+)acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients. METHODS: A total of 1056 HLA-B27(+) AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27(+)AS(+) and HLA-B27(+)AS(-) group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28605750/anticentromere-antibody-positive-ackerman-s-syndrome-with-granulomatous-anterior-uveitis
#19
Susana Rilhas Fernandes, Vera Las, Joana Borges, Cândida Silva, Augusto Faustino
Ackerman's Syndrome or Intersticial Granulomatous Dermatitis with Arthritis has been an issue of increasing number of reports in the last decade which had focused its heterogeneous cutaneous and rheumatologic expression besides the initial manifestations reported by Ackerman and his group. Granulomatosis anterior uveitis has not been previously described. Some patients are reported to have positive autoantibodies but association with anticentromere antibodies has not been previously described as well, to our knowledge...
June 12, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28602016/long-term-results-of-cataract-surgery-in-patients-with-anterior-uveitis
#20
Ozgur Balta, Gulten Sungur, Mehmet Akif Acar, Mustafa Kosker, Mehmet Yakin, Firdevs Ornek
PURPOSE: This study was aimed to assess the long-term results of phacoemulsification and posterior chamber intraocular lens implantation in patients with anterior uveitis. METHODS: Patients with complicated cataract secondary to anterior uveitis who underwent phacoemulsification and posterior chamber intraocular lens implantation were included in this study. Long-term results and all complications were evaluated throughout the postoperative 4 years. RESULTS: A total of 55 eyes of 48 patients were identified in this study...
June 10, 2017: International Ophthalmology
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