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Uveitis anterior

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https://www.readbyqxmd.com/read/29324594/intraoperative-and-postoperative-complications-in-phacovitrectomy-for-epiretinal-membrane-and-macular-hole-a-clinical-audit-of-1000-consecutive-eyes
#1
Mark A P Fajgenbaum, James E Neffendorf, Roger S Wong, David A H Laidlaw, Tom H Williamson
PURPOSE: The aim of this study was to report the intraoperative and postoperative complications of phacovitrectomy for epiretinal membrane (ERM) and macular hole (MH). METHODS: This was a retrospective audit of 1,052 phacovitrectomy operations (410 for ERM and 642 for MH) by the same surgical team between 1998 and 2017. Outcome measures included rates of intraoperative anterior segment and posterior segment complications such as posterior capsule rupture and retinal breaks...
January 10, 2018: Retina
https://www.readbyqxmd.com/read/29323215/green-tea-extract-attenuates-lps-induced-retinal-inflammation-in-rats
#2
Jia Lin Ren, Qiu Xiao Yu, Wei Cheng Liang, Pui Ying Leung, Tsz Kin Ng, Wai Kit Chu, Chi Pui Pang, Sun On Chan
Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE on lipopolysaccharides (LPS)-induced retinal inflammation in rats and explored the underlying mechanism. Adult rats were injected with LPS and GTE was administered intra-gastrically at 2, 8, 26 and 32 hours post-injection. Staining of whole-mount retina showed that the number of activated microglia cells was significantly increased at 48 hours post-injection, which was suppressed after GTE treatment in a dose-dependent manner...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318438/presumed-tuberculous-uveitis-in-a-university-based-tertiary-referral-center-in-saudi-arabia
#3
Awad Al-Qarni, Marwan A Abouammoh, Abdullah N Almousa, Ahmed Mousa, Ahmed M Abu El-Asrar
PURPOSE: To describe clinical characteristics and outcomes of treatment in patients with presumed tuberculous uveitis (PTU). METHODS: All patients diagnosed with PTU between January 1996 and March 2013 were reviewed. The diagnosis was made when clinical findings were consistent with possible intraocular tuberculosis, strongly positive purified protein derivative (PPD) skin test result, and response to anti-tuberculous therapy with no other cause of uveitis as suggested by history, symptoms, or ancillary testing...
January 9, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29310395/delayed-onset-of-pressure-induced-interlamellar-stromal-keratitis-in-a-patient-with-recurrent-uveitis-a-case-report
#4
Che-Yuan Kuo, Yu-Fan Chang, Yu-Bai Chou, Chih-Chien Hsu, Pei-Yu Lin, Catherine Jui-Ling Liu
INTRODUCTION: Corticosteroid treatment for uveitis can lead to delayed-onset pressure-induced interlamellar stromal keratitis (PISK), even years after laser in situ keratomileusis (LASIK).A 35-year-old man presented to our clinic after experiencing blurred vision in his left eye for 1 month. For the past month, he had been prescribed topical steroid and anti-glaucomatous medication. He had undergone LASIK for both eyes 5 years earlier, and had suffered uveitis attacks in his left eye over the last 2 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29303704/golimumab-in-refractory-uveitis-associated-to-juvenile-idiopathic-arthritis-multicentre-study-of-7-cases-and-literature-review
#5
REVIEW
Natalia Palmou-Fontana, Vanesa Calvo-Río, José Luis Martín-Varillas, Carlos Fernández-Díaz, Marina Mesquida, Alfredo Adán, María Victoria Hernández, Miguel Cordero-Coma, Olga Maiz Alonso, David Díaz-Valle, Carlos Fernández-Cid, Oscar Ruiz-Moreno, José Luis Hernández, Miguel Angel González-Gay, Ricardo Blanco
OBJECTIVES: To assess the efficacy of golimumab (GLM), a fully humanised anti-TNF-α monoclonal antibody, in refractory juvenile idiopathic arthritis (JIA)-associated uveitis. METHODS: This was a multicentre study of JIA-associated uveitis refractory to standard synthetic immunosuppressive drugs and in most cases to other anti-TNF-α agents. Results were expressed as mean±standard deviation or as median (range or interquartile range). The Wilcoxon signed-rank test was used to compare continuous variables...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29297723/uveitis-referral-pattern-in-upper-and-lower-egypt
#6
Eiman Abd El Latif, Hatem Ammar
PURPOSE: To report the pattern of uveitis in two referral eye hospitals, one in Upper Egypt and another in Lower Egypt Methods: Retrospective chart review of all uveitis cases visiting the uveitis clinic in Alexandria and Sohag University Hospitals between May 2010 and March 2017. RESULTS: A total of 1315 patients (683 in Upper Egypt and 632 in Lower Egypt) were identified. Uveitis was bilateral in 56.6% of patients in Upper Egypt and in 43.6% of patients in Lower Egypt...
January 3, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29297055/pharmacology-of-corticosteroids-for-diabetic-macular-edema
#7
Scott M Whitcup, John A Cidlowski, Karl G Csaky, Jayakrishna Ambati
Purpose: Corticosteroids remain the mainstay of treatment for inflammatory diseases almost 80 years after their first clinical use. Topical ophthalmic formulations of corticosteroids have been available to treat disease of the anterior segment of the eye, but the approval of corticosteroids to treat vitreoretinal diseases, including vein occlusion, diabetic macular edema, and uveitis, has occurred only recently. Although most diseases respond to corticosteroid therapy, some patients are resistant to this therapy and side effects, including cataract and elevated intraocular pressure, can limit their use...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29290458/anterior-uveitis
#8
REVIEW
J Gueudry, M Muraine
Anterior Uveitis is the most common form of uveitis. There are several known and many possible etiologies for anterior uveitis. After examining the posterior segment and ruling out masquerade syndromes, the main step of etiologic diagnosis is clinical characterization. It is essential to establish the presence or absence of unilateral versus bilateral and granulomatous features. Subsequently, a directed work-up may be obtained which then helps to confirm diagnostic hypotheses based on the detailed history and clinical examination...
December 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29286865/randomized-controlled-study-to-evaluate-the-efficacy-of-adalimumab-in-patients-with-different-forms-of-refractory-uveitis
#9
Friederike Mackensen, Carsten Heinz, Eva Jakob, Viviane Grewing, Hanns-Martin Lorenz, Arnd Heiligenhaus, Regina Max, Matthias D Becker
PURPOSE: TNF alpha inhibitors have revolutionized the care of vision-threatening uveitis. This study evaluated the efficacy of adalimumab (ADA) for the treatment of refractory noninfectious uveitis. DESIGN: Randomized, prospective, controlled, two-center clinical trial Methods: Patients with active uveitis despite combined oral low-dose prednisolone and immunosuppression were randomized for additional ADA with corticosteroids in a fixed tapering regime, or corticosteroids only...
December 29, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29283745/polymerase-chain-reaction-and-goldmann-witmer-coefficient-testing-in-the-diagnosis-of-infectious-uveitis-in-hiv-positive-and-hiv-negative-patients-in-south-africa
#10
Derrick P Smit, David Meyer, Tonya M Esterhuizen, Jolanda D F De Groot-Mijnes
PURPOSE: To use polymerase chain reaction (PCR) and Goldmann-Witmer coefficient (GWC) calculation to diagnose infectious uveitis. METHODS: Prospective cross-sectional study. RESULTS: Twenty-seven of 106 patients had positive PCR and/or GWC results on aqueous humor (AH) sampling and 15 of 27 (55.6%) were HIV-positive. Patients with non-anterior uveitis (NAU) were more likely to be HIV+ (p = 0.005). More than 1 possible pathogen was identified in 9 of 27 patients of whom 7 were HIV+...
December 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29275333/adjuvite-a-double-blind-randomised-placebo-controlled-trial-of-adalimumab-in-early-onset-chronic-juvenile-idiopathic-arthritis-associated-anterior-uveitis
#11
Pierre Quartier, Amandine Baptiste, Véronique Despert, Emma Allain-Launay, Isabelle Koné-Paut, Alexandre Belot, Laurent Kodjikian, Dominique Monnet, Michel Weber, Caroline Elie, Bahram Bodaghi
OBJECTIVES: To assess the efficacy and safety of adalimumab on uveitis in patients with early onset, chronic, juvenile idiopathic arthritis (JIA)-associated or idiopathic anterior uveitis and an inadequate response to topical steroids and methotrexate (MTX). METHODS: Patients aged 4 years or more with ocular inflammation quantified by laser flare photometry (LFP) ≥30 photon units/ms were double-blindly randomised (1:1) to 2 groups, one treated with placebo and one with adalimumab subcutaneously at a dose of 24 mg/m2 in patients aged <13 years, 40 mg in the others, every other week...
December 23, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29261089/the-collaborative-ocular-tuberculosis-study-cots-1-report-3-polymerase-chain-reaction-in-the-diagnosis-and-management-of-tubercular-uveitis-global-trends
#12
Aniruddha Agarwal, Rupesh Agrawal, Dinesh Visva Gunasekaran, Dhananjay Raje, Bhaskar Gupta, Kanika Aggarwal, Somasheila L Murthy, Mark Westcott, Soon Phaik Chee, Peter Mccluskey, Ho Su Ling, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A Goldstein, Carl P Herbort, Talin Barisani-Asenbauer, Julio J González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Sarakshi Mahajan, Simona Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett Cunningham, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
PURPOSE: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. METHODS: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. RESULTS: 59 (6.13%) of COTS-1 underwent PCR analysis...
December 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29260952/difluprednate-0-05-versus-prednisolone-acetate-1-for-endogenous-anterior-uveitis-pooled-efficacy-analysis-of-two-phase-3-studies
#13
John D Sheppard, C Stephen Foster, Melissa M Toyos, Kerry Markwardt, Robert Da Vanzo, Thomas E Flynn, John H Kempen
PURPOSE: To analyse pooled data from 2 similar phase 3 noninferiority studies comparing difluprednate 0.05% versus prednisolone acetate 1% in patients with endogenous anterior uveitis. METHODS: Patients received difluprednate alternating with vehicle or prednisolone acetate for 14 days (8 drops/day in both groups), followed by tapering from day 14 to 28. All patients were observed until day 42. RESULTS: More patients on difluprednate than on prednisolone acetate were cleared of anterior chamber cells on day twenty one (71...
December 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29260111/corneal-graft-failure-due-to-migration-of-ozurdex%C3%A2-implant-into-the-anterior-chamber
#14
Haifa A Madi, Stephen J Morgan, Saurabh Ghosh
Purpose: We report a case of corneal endothelial graft failure secondary to dexamethasone intravitreal implant (Ozurdex™) migration into the anterior chamber (AC). Observations: A 53-year-old man with a history of bilateral idiopathic chronic uveitis, had a right anterior vitrectomy and AC intraocular lens (ACIOL) with a peripheral iridotomy. He received an intravitreal Ozurdex™ implant for right cystoid macular oedema (CMO). Three months later he developed pseudophakic bullous keratopathy and underwent a Descemet stripping automated endothelial keratoplasty (DSAEK), combined with IOL exchange (ACIOL explantation followed by scleral fixated posterior chamber IOL)...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260068/tuberculous-uveitis-presenting-as-pigmented-hypopyon-a-case-report
#15
Sachin B Shetty, Santhosh H Devulapally, Sowmiya Murali, Jaydeep A Walinjkar, Jyotirmay Biswas
Purpose: Hypopyon in the eye is an alarming sign. A case of tuberculous uveitis which presented with pigmented hypopyon has been described. The aim of this paper is to report pigmented hypopyon, a rare presentation of tuberculous uveitis in a diabetic patient. Observations: A 42-year-old patient with diabetes with a known history of miliary tuberculosis, on anti-tubercular therapy since two months presented with complaints of pain and redness followed by diminution of vision in the right eye since one month...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260064/bilateral-uveitis-following-intravenous-immunoglobulin-administration
#16
Enis D Kocak, Bob Z Wang, Anthony J Hall
Purpose: To report a case of bilateral acute anterior uveitis in an adult female occurring following the administration of intravenous immunoglobulin (IVIG). Observations: A 44-year-old female patient was commenced on IVIG following presentation to hospital with upper limb neuropathic pain. Within two days, she developed bilateral red, painful photophobic eyes. Examination revealed bilateral acute anterior uveitis and IVIG was ceased. Investigations for autoimmune or infective causes for the uveitis were unremarkable...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260055/isolated-endogenous-fusarium-endophthalmitis-in-an-immunocompetent-adult-after-a-thorn-prick-to-the-hand
#17
Alice L Milligan, Anna M Gruener, Iain D Milligan, Geraldine A O'Hara, Miles R Stanford
Purpose: To report the case of an immunocompetent adult presenting with endogenous Fusarium endophthalmitis. Observations: A woman in her thirties presented with symptoms and signs of a unilateral anterior uveitis. After initial improvement with topical corticosteroids, she continued to develop a panuveitis with an associated drop in vision to counting fingers. A vitreous biopsy confirmed Fusarium solani by 18S rRNA fungal gene detection and PCR sequencing. Despite treatment with pars plana vitrectomy, intravitreal amphotericin B and systemic voriconazole her visual outcome was poor...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29260047/bilateral-acute-simultaneous-onset-anterior-uveitis-presumed-secondary-to-erlotinib-a-report-of-two-cases
#18
Kendra A Klein, Christopher G Azzoli, Lana M Rifkin
Purpose: To report two new cases of presumed erlotinib-associated bilateral acute simultaneous-onset anterior uveitis effectively treated with topical steroids. Observations: Two patients were referred to the uveitis clinic with bilateral acute simultaneous onset, anterior uveitis six weeks after starting the chemotherapeutic agent erlotinib. Frequent topical steroid were started and the inflammation responded swiftly and completely. Conclusions and importance: Bilateral acute simultaneous onset anterior uveitis is a potential side effect associated with erlotinib use that has not been well described...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29239680/the-spots-system-an-ocular-scoring-system-optimized-for-use-in-modern-preclinical-drug-development-and-toxicology
#19
Joshua Seth Eaton, Paul E Miller, Ellison Bentley, Sara M Thomasy, Christopher J Murphy
PURPOSE: To present a semiquantitative ocular scoring system comprising elements and criteria that address many of the limitations associated with systems commonly used in preclinical studies, providing enhanced cross-species applicability and predictive value in modern ocular drug and device development. METHODS: Revisions to the ocular scoring systems of McDonald-Shadduck and Hackett-McDonald were conducted by board-certified veterinary ophthalmologists at Ocular Services On Demand (OSOD) over the execution of hundreds of in vivo preclinical ocular drug and device development studies and general toxicological investigations...
December 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29226649/comparison-of-the-diagnostic-power-of-serum-il-6-il-8-and-tnf-%C3%AE-for-the-idiopathic-anterior-uveitis-in-children
#20
Beata Zelazowska-Rutkowska, Malgorzata Mrugacz, Bogdan Cylwik
BACKGROUND: Uveitis is the inflammation of the uvea that often occurs in children. There are many causes of disease, but some of them do not have any reasons and are then called idiopathic uveitis. Cytokines play an important role in the regulation of the immune response. Determination of cytokine profiles could contribute to the explanation of the etiology of uveitis and could serve to evaluate the inflammation intensity as well as be helpful in the early diagnosis this disease. The purpose of this study was to determine the serum level of selected inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF-α) and to compare their diagnostic power as a markers of idiopathic anterior uveitis in children...
November 1, 2017: Clinical Laboratory
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