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https://www.readbyqxmd.com/read/29067278/prophylactic-lateral-pelvic-lymph-node-dissection-in-stage-iv-low-rectal-cancer
#1
Hiroshi Tamura, Yoshifumi Shimada, Hitoshi Kameyama, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Mae Nakano, Masato Nakano, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Shin-Ichi Kosugi, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Toshifumi Wakai
AIM: To assess the clinical significance of prophylactic lateral pelvic lymph node dissection (LPLND) in stage IV low rectal cancer. METHODS: We selected 71 consecutive stage IV low rectal cancer patients who underwent primary tumor resection, and enrolled 50 of these 71 patients without clinical LPLN metastasis. The patients had distant metastasis such as liver, lung, peritoneum, and paraaortic LN. Clinical LPLN metastasis was defined as LN with a maximum diameter of 10 mm or more on preoperative pelvic computed tomography scan...
October 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29016859/a-functional-variant-in-mir4300hg-the-host-gene-of-microrna-mir4300-is-associated-with-progression-of-adolescent-idiopathic-scoliosis
#2
Yoji Ogura, Ikuyo Kou, Yohei Takahashi, Kazuki Takeda, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Michiaki Kubo, Yoichiro Kamatani, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity affecting millions of children. Since treatment and prognosis of AIS depend on curve progression, identifying factors related to AIS curve progression is important in its management. Although several genetic loci for AIS occurrence are reported, no locus for curve progression has been identified. To identify genes associated with AIS progression, we conducted a genome-wide association study followed by a replication study using a total of 2,543 AIS subjects who were evaluated for the curve progression...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28984565/risk-factors-for-and-role-of-oprd-protein-in-increasing-minimal-inhibitory-concentrations-of-carbapenems-in-clinical-isolates-of-pseudomonas-aeruginosa
#3
Aki Hirabayashi, Daizo Kato, Yuka Tomita, Mitsutaka Iguchi, Keiko Yamada, Yuichi Kouyama, Hiroshi Morioka, Nobuyuki Tetsuka, Tetsuya Yagi
PURPOSE: This study examined the risk factors for, and molecular mechanisms underlying, the increase in carbapenem minimum inhibitory concentrations (MICs) in clinical isolates of Pseudomonas aeruginosa. METHODOLOGY: Consecutive clinical isolates of P. aeruginosa were collected. The MicroScan WalkAway system detected more than fourfold increases in the MICs of carbapenems in P. aeruginosa isolates serially recovered from some patients during their clinical course...
October 6, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28925039/clinical-predictive-factors-of-long-term-survival-after-curative-resection-of-pancreatic-cancer-a-retrospective-study
#4
Yutaka Nakano, Minoru Kitago, Masahiro Shinoda, Yuta Abe, Hiroshi Yagi, Taizo Hibi, Ayano Takeuchi, Koichi Aiura, Osamu Itano, Yuko Kitagawa
Pancreatic ductal adenocarcinoma (PDAC) continues to have the poorest prognosis of all gastrointestinal malignancies, even after the tumor has been completely resected. However, only a proportion of patients achieve 5-year survival after resection. The factors predictive of achieving 5-year survival remain unclear. The aim of this study was to investigate the pre- and postoperative clinicopathological characteristics of PDAC patients with a >5-year survival after curative resection. We retrospectively reviewed patients who underwent pancreatectomy for PDAC between January 1995 and December 2011...
October 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28902104/a-replication-study-for-the-association-of-rs11190870-with-curve-severity-in-adolescent-idiopathic-scoliosis-in-japanese
#5
Yohei Takahashi, Ikuyo Kou, Yoji Ogura, Atsushi Miyake, Kazuki Takeda, Masahiro Nakajima, Shohei Minami, Noriaki Kawakami, Koki Uno, Manabu Ito, Ikuho Yonezawa, Takashi Kaito, Haruhisa Yanagida, Kei Watanabe, Hiroshi Taneichi, Katsumi Harimaya, Yuki Taniguchi, Toshiaki Kotani, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Nobuyuki Fujita, Mitsuru Yagi, Kazuhiro Chiba, Katsuki Kono, Tsuyoshi Sakuma, Tsutomu Akazawa, Kotaro Nishida, Kenichiro Kakutani, Hideki Shigematsu, Takahiro Iida, Satoshi Demura, Naobumi Hosogane, Eijiro Okada, Masaya Nakamura, Morio Matsumoto, Kota Watanabe, Shiro Ikegawa
STUDY DESIGN: Case-only study. OBJECTIVE: The aim of this study was to confirm the association of rs11190870 with AIS severity in Japanese patients with AIS. SUMMARY OF BACKGROUND DATA: Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28880697/tentative-diagnostic-criteria-and-disease-severity-classification-for-castleman-disease-a-report-of-the-research-group-on-castleman-disease-in-japan
#6
Shino Fujimoto, Tomohiro Koga, Atsushi Kawakami, Hiroshi Kawabata, Shinichiro Okamoto, Masao Mizuki, Shingo Yano, Makoto Ide, Kazuko Uno, Katsumi Yagi, Toshiyuki Kojima, Minoru Mizutani, Yukihiro Tokumine, Norihiro Nishimoto, Hiroshi Fujiwara, Shin-Ichi Nakatsuka, Kazuko Shiozawa, Noriko Iwaki, Yasufumi Masaki, Kazuyuki Yoshizaki
OBJECTIVES: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population. METHODS: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28858131/recurrent-bacteremia-and-liver-abscess-caused-by-clostridium-difficile-a-case-report
#7
Hiroshi Morioka, Mitsutaka Iguchi, Teiji Kuzuya, Hiroshige Mikamo, Tetsuya Yagi
RATIONALE: Clostridium difficile bacteremia (CDB) and liver abscess is a quite rare presentation of C. difficile infection. PATIENTS CONCERNS: A 74-year-old male with primary biliary cirrhosis and hepatocellular carcinoma who underwent transarterial chemoembolization (TACE) developed a high fever on post-TACE day 14. Intravenous ceftriaxone and following meropenem were administered, however, his clinical response was poor. On post-TACE day 24, 2 sets of blood culture were taken due to elevation of C-reactive protein levels...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28856628/primary-colonic-well-differentiated%C3%A2-%C3%A2-dedifferentiated-liposarcoma-of-the-ascending-colon-a-case-report
#8
Hiroshi Sawayama, Naoya Yoshida, Yuji Miyamoto, Tomoyuki Uchihara, Tasuku Toihata, Taisuke Yagi, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Hideo Baba
BACKGROUND: Primary colonic and dedifferentiated liposarcomas are both remarkably rare. This work describes a case of primary colonic well-differentiated/dedifferentiated liposarcoma and reviews the clinical characteristics and current therapies for liposarcoma tumors. CASE PRESENTATION: A 52-year-old woman was referred to our hospital with a submucosal tumor of the ascending colon. Clinical analysis by ultrasound colonoscopy and computed tomography revealed a partially ossified tumor with irregular edges continuous with the muscular layer...
August 30, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28793869/the-efficacy-safety-and-feasibility-of-inhaled-amikacin-for-the-treatment-of-difficult-to-treat-non-tuberculous-mycobacterial-lung-diseases
#9
Kazuma Yagi, Makoto Ishii, Ho Namkoong, Takahiro Asami, Osamu Iketani, Takanori Asakura, Shoji Suzuki, Hiroaki Sugiura, Yoshitake Yamada, Tomoyasu Nishimura, Hiroshi Fujiwara, Yohei Funatsu, Yoshifumi Uwamino, Tetsuro Kamo, Sadatomo Tasaka, Tomoko Betsuyaku, Naoki Hasegawa
BACKGROUND: In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with difficult-to-treat NTM lung diseases in a retrospective chart review. METHODS: The study population consisted of patients with NTM lung diseases who received combination therapy, including inhaled AMK therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28668900/serum-heparin-binding-epidermal-growth-factor-like-growth-factor-hb-egf-as-a-biomarker-for-primary-ovarian-cancer
#10
Kohei Miyata, Fusanori Yotsumoto, Satoshi Fukagawa, Chihiro Kiyoshima, Nam Sung Ouk, Daichi Urushiyama, Tomohiro Ito, Takahiro Katsuda, Masamitsu Kurakazu, Ryota Araki, Ayako Sanui, Daisuke Miyahara, Masaharu Murata, Kyoko Shirota, Hiroshi Yagi, Tadao Takono, Kiyoko Kato, Nobuo Yaegashi, Kohei Akazawa, Masahide Kuroki, Shin'ichiro Yasunaga, Shingo Miyamoto
Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational therapeutic target for ovarian cancer. Here, we evaluated the clinical significance of serum HB-EGF by examining the association between prognosis and serum HB-EGF levels in patients with primary ovarian cancer...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28626871/successful-living-donor-liver-retransplantation-for-graft-failure-within-7%C3%A2-days-due-to-acute-de-novo-donor-specific-anti-human-leukocyte-antigen-antibody-mediated-rejection
#11
Yohei Yamada, Ken Hoshino, Teisaburo Mori, Miho Kawaida, Kiyotomo Abe, Hideo Ishihama, Takahiro Shimizu, Nobuhiro Takahashi, Kentaro Matsubara, Taizo Hibi, Yuta Abe, Hiroshi Yagi, Naoki Shimojima, Masahiro Shinoda, Minoru Kitago, Hideaki Obara, Yasushi Fuchimoto, Kaori Kameyama, Yuko Kitagawa, Tatsuo Kuroda
Growing evidence suggests a relationship between antibody-mediated rejection (AMR) and early graft failure due to a previously unknown etiology in liver transplantation (LTx). We herein report a 3-year-old boy who developed rapid graft failure due to de novo donor-specific antibody (DSA)-driven AMR a week after living donor LTx, requiring a second transplant on the 10th day after the first LTx. The pathology of the first graft showed massive necrosis in zone 3 along with positive C4d and inflammatory cell infiltrates in portal areas...
June 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28601316/oral-administration-of-cilostazol-improves-survival-rate-after-rat-liver-ischemia-reperfusion-injury
#12
Taku Fujii, Hideaki Obara, Kentaro Matsubara, Naoki Fujimura, Hiroshi Yagi, Taizo Hibi, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Osamu Itano, Minoru Tanabe, Yohei Masugi, Michiie Sakamoto, Yuko Kitagawa
BACKGROUND: Cilostazol is a type III phosphodiesterase inhibitor used to treat the symptoms of intermittent claudication. Recent studies have shown that cilostazol decreases ischemia/reperfusion (I/R) injury in several organs. MATERIALS AND METHODS: We evaluated the effects of cilostazol in a rat model of liver I/R injury. Thirty male Wistar rats with liver I/R injury were divided into a cilostazol or saline (control) group (n = 15 each). Each rat was orally administered cilostazol or saline for 3 d before I/R injury...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28560018/internal-hernia-after-laparoscopic-right-hemicolectomy-report-of-a-case
#13
Hiroki Sugita, Takahiko Akiyama, Naoya Daitoku, Rumiko Tashima, Hiroshi Tanaka, Shinobu Honda, Tetsumasa Arita, Yasushi Yagi, Masahiko Hirota
Mesenteric defects are often not closed in laparoscopic colectomy. We herein report a case of an internal hernia projecting through a mesenteric defect following laparoscopy-assisted right hemicolectomy. A 74-year-old woman was hospitalized for the surgical treatment of double colon cancer. Preoperative colonoscopy demonstrated the presence of ascending colon and transverse colon cancers. A laparoscopic-assisted right hemicolectomy was performed. The mesenteric defect resulting from the colectomy was not closed...
May 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28551681/neoadjuvant-chemoradiotherapy-for-stage-ii-or-iii-esophageal-squamous-cell-carcinoma
#14
Takaharu Kawai, Mitsugu Kochi, Masashi Fujii, Keio Song, Ken Hagiwara, Megumu Watanabe, Yoritaka Matsuno, Hiroshi Suda, Renpei Yagi, Tadatoshi Takayama
BACKGROUND/AIM: The goal of this retrospective study was to investigate the efficacy and safety of neoadjuvant chemoradiotherapy (CRT) in patients with Stage II or Stage III esophageal squamous cell carcinoma (SCC). PATIENTS AND METHODS: Between January 2004 and December 2014, a total of 86 patients underwent surgical resection in conjunction with preoperative CRT for esophageal SCC in our Institute. RESULTS: A pathological complete response was achieved in 38...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28484370/clustered-protocadherins-are-required-for-building-functional-neural-circuits
#15
Sonoko Hasegawa, Hiroaki Kobayashi, Makiko Kumagai, Hiroshi Nishimaru, Etsuko Tarusawa, Hiro Kanda, Makoto Sanbo, Yumiko Yoshimura, Masumi Hirabayashi, Takahiro Hirabayashi, Takeshi Yagi
Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically with that in other neurons in trans, it has been thought that the Pcdh isoform repertoire determines the binding specificity of synapses. We previously described the cooperative functions of isoforms from all three Pcdh gene clusters in neuronal survival and synapse formation in the spinal cord...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28446822/anti-mycobacterium-activity-of-microbial-peptides-in-a-silkworm-infection-model-with-mycobacterium-smegmatis
#16
Akiho Yagi, Ryuji Uchida, Hiroshi Hamamoto, Kazuhisa Sekimizu, Ken-Ichi Kimura, Hiroshi Tomoda
An in vivo-mimic silkworm infection model with Mycobacterium smegmatis was established. When silkworms were raised at 37 °C following an injection of M. smegmatis cells (1.25 × 10(7) CFU larva(-1) g(-1)) into the silkworm hemolymph, they died within 48 h. Under these conditions, four microbial peptides with anti-M. smegmatis activity, lariatin A, calpinactam, lysocin E and propeptin, exerted therapeutic effects in a dose-dependent manner, and these are also clinically used agents that are active against Mycobacterium tuberculosis...
May 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28418019/live-imaging-of-h3k9-acetylation-in-plant-cells
#17
Kazuki Kurita, Takuya Sakamoto, Noriyoshi Yagi, Yuki Sakamoto, Akihiro Ito, Norikazu Nishino, Kaori Sako, Minoru Yoshida, Hiroshi Kimura, Motoaki Seki, Sachihiro Matsunaga
Proper regulation of histone acetylation is important in development and cellular responses to environmental stimuli. However, the dynamics of histone acetylation at the single-cell level remains poorly understood. Here we established a transgenic plant cell line to track histone H3 lysine 9 acetylation (H3K9ac) with a modification-specific intracellular antibody (mintbody). The H3K9ac-specific mintbody fused to the enhanced green fluorescent protein (H3K9ac-mintbody-GFP) was introduced into tobacco BY-2 cells...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28413396/mammary-analogue-secretory-carcinoma-presenting-as-a-cervical-lymph-node-metastasis-of-unknown-primary-site-a-case-report
#18
Kensuke Suzuki, Masao Yagi, Akira Kanda, Yoshiki Kobayashi, Masaya Konishi, Chika Miyasaka, Takashi Tashiro, Hiroshi Iwai
BACKGROUND: Mammary analogue secretory carcinoma (MASC) is a pathological entity arising in the salivary glands first described by Skalova et al. [Am J Surg Pathol 2010;34: 599-608]. Here, we report the first case of MASC presenting as a cervical lymph node metastasis of unknown primary site together with a brief review of the literature. CASE REPORT: We present a 74-year-old male with a painless lump in his left neck. Based on the fine-needle aspiration cytological findings, a possible malignant tumor was suspected...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28328981/dysbiosis-and-compositional-alterations-with-aging-in-the-gut-microbiota-of-patients-with-heart-failure
#19
Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun-Ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro
Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure (HF). However, it is still unknown whether HF is associated with dysbiosis in gut microbiota. We investigated the composition of gut microbiota in patients with HF to elucidate whether gut microbial dysbiosis is associated with HF. We performed 16S ribosomal RNA gene sequencing of fecal samples obtained from 12 HF patients and 12 age-matched healthy control (HC) subjects, and analyzed the differences in gut microbiota...
2017: PloS One
https://www.readbyqxmd.com/read/28320204/coordination-nanosheets-based-on-terpyridine-zinc-ii-complexes-as-photoactive-host-materials
#20
Takamasa Tsukamoto, Kenji Takada, Ryota Sakamoto, Ryota Matsuoka, Ryojun Toyoda, Hiroaki Maeda, Toshiki Yagi, Michihiro Nishikawa, Naoaki Shinjo, Shuntaro Amano, Tadashi Iokawa, Narutaka Ishibashi, Tsugumi Oi, Koshiro Kanayama, Rina Kinugawa, Yoichiro Koda, Toshiyuki Komura, Shuhei Nakajima, Ryota Fukuyama, Nobuyuki Fuse, Makoto Mizui, Masashi Miyasaki, Yutaro Yamashita, Kuni Yamada, Wenxuan Zhang, Ruocheng Han, Wenyu Liu, Taro Tsubomura, Hiroshi Nishihara
Photoluminescent coordination nanosheets (CONASHs) comprising three-way terpyridine (tpy) ligands and zinc(II) ions are created by allowing the two constitutive components to react with each other at a liquid/liquid interface. Taking advantage of bottom-up CONASHs, or flexibility in organic ligand design and coordination modes, we demonstrate the diversity of the tpy-zinc(II) CONASH in structures and photofunctions. A combination of 1,3,5-tris[4-(4'-2,2':6',2″-terpyridyl)phenyl]benzene (1) and Zn(BF4)2 affords a cationic CONASH featuring the bis(tpy)Zn complex motif (1-Zn), while substitution of the zinc source with ZnSO4 realizes a charge-neutral CONASH with the [Zn2(μ-O2SO2)2(tpy)2] motif [1-Zn2(SO4)2]...
April 4, 2017: Journal of the American Chemical Society
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