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Yagi hiroshi

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https://www.readbyqxmd.com/read/29764373/a-subclinical-high-tricuspid-regurgitation-pressure-gradient-independent-of-the-mean-pulmonary-artery-pressure-is-a-risk-factor-for-the-survival-after-living-donor-liver-transplantation
#1
Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike, Fusao Ikeda, Hideki Onishi, Hidenori Shiraha, Shinichiro Nakamura, Hiroshi Morimatsu, Hiroshi Ito, Toshiyoshi Fujiwara, Takahito Yagi, Hiroyuki Okada
BACKGROUND: Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after orthotopic liver transplantation (OLT), as the congestive pressure affects the grafted liver, while subclinical pulmonary hypertension (PH) has been acknowledged as a non-risk factor for deceased donor OLT. Given that PH measurement requires cardiac catheterization, the tricuspid regurgitation pressure gradient (TRPG) measured by echocardiography is used to screen for PH and congestive pressure to the liver...
May 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29758369/intraoperative-active-bleeding-in-endoscopic-surgery-for-spontaneous-intracerebral-hemorrhage-is-predicted-by-the-spot-sign
#2
Koichi Miki, Kenji Yagi, Masani Nonaka, Mitsutoshi Iwaasa, Hiroshi Abe, Takashi Morishita, Hisatomi Arima, Tooru Inoue
BACKGROUND: Endoscopic evacuation of hematoma (EEH) has recently been applied to treat patients with spontaneous intracerebral hemorrhage (sICH). Intraoperative active bleeding (IAB), which is occasionally observed in EEH, might lead to greater blood loss, further brain damage, and more postoperative recurrent hemorrhage. However, no definite predictor of IAB has been established. Because the spot sign is associated with other hemorrhagic complications, we aimed to evaluate whether it predicts IAB...
May 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29721347/endoscopic-surgery-via-a-combined-frontal-and-suboccipital-approach-for-cerebellar-hemorrhage
#3
Masani Nonaka, Kenji Yagi, Hiroshi Abe, Koichi Miki, Takashi Morishita, Mitsutoshi Iwaasa, Tooru Inoue
Background: Spontaneous cerebellar hemorrhages (CHs), which frequently require surgical intervention, are life-threatening and can be complicated by intraventricular hemorrhages (IVHs) and obstructive hydrocephalus. Commonly, endoscopic surgery is performed to remove CHs via a suboccipital approach (SA) alone. At our institution, when patients exhibited supratentorial IVH-associated hydrocephalus, we used a combined frontal and suboccipital approach (CA) to evacuate both CHs and supratentorial IVHs...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29706644/distinct-variants-affecting-differential-splicing-of-tgfbr1-exon-5-cause-either-loeys-dietz-syndrome-or-multiple-self-healing-squamous-epithelioma
#4
Takayuki Fujiwara, Norifumi Takeda, Hironori Hara, Hiroyuki Morita, Jun Kishihara, Ryo Inuzuka, Hiroki Yagi, Sonoko Maemura, Haruhiro Toko, Mutsuo Harada, Yuichi Ikeda, Hidetoshi Kumagai, Seitaro Nomura, Eiki Takimoto, Hiroshi Akazawa, Junya Ako, Issei Komuro
Variants in TGFBR1 have been reported to induce two completely distinct diseases, namely Loeys-Dietz syndrome (LDS) and multiple self-healing squamous epithelioma (MSSE). However, detailed mechanisms underlying this effect remain unknown. We report a Japanese familial case of LDS with a novel splice donor site variant in TGFBR1 gene (c.973 + 1 G > A; NG_007461.1). The intronic variant was predicted to mediate in-frame exon 5 skipping within the serine/threonine kinase (STK) domain, which may also be mediated by a similar TGFBR1 variant of a splice acceptor site in intron 4 (c...
April 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29690869/concurrent-presentation-of-an-intraductal-tubulopapillary-neoplasm-and-intraductal-papillary-mucinous-neoplasm-in-the-branch-duct-of-the-pancreas-with-a-superior-mesenteric-artery-aneurysm-a-case-report
#5
Kenta Inomata, Minoru Kitago, Hideaki Obara, Yoko Fujii-Nishimura, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Kentaro Matsubara, Go Oshima, Yasuhito Sekimoto, Masazumi Inoue, Osamu Itano, Michiie Sakamoto, Yuko Kitagawa
BACKGROUND: Since the concept of intraductal tubulopapillary neoplasm (ITPN) was introduced in the current World Health Organization classification of tumors, the number of reports of ITPN occurrence has increased gradually. However, ITPN is usually located in the main pancreatic duct, with few reports of a branch duct ITPN. As a result, imaging protocols for the diagnosis of a branch duct ITPN have not been established. CASE PRESENTATION: We report a case of a concurrent presentation of a branch duct ITPN and intraductal papillary mucinous neoplasm (IPMN) in the head of the pancreas, with a superior mesenteric artery (SMA) aneurysm...
April 24, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29549818/feasibility-and-psychometric-properties-of-the-ucla-ptsd-reaction-index-for-dsm-5-in-japanese-youth-a-multi-site-study
#6
Saeko Takada, Satomi Kameoka, Makiko Okuyama, Takeo Fujiwara, Junko Yagi, Yoshitaka Iwadare, Hiroaki Honma, Hirohumi Mashiko, Keizo Nagao, Takeshi Fujibayashi, Yasuko Asano, Sayaka Yamamoto, Tomoko Osawa, Hiroshi Kato
The purpose of this study was to determine the reliability and validity of the UCLA PTSD Reaction Index for DSM-5 (PTSD-RI-5) among Japanese youth. This is the first study to explore psychometrics of the DSM-5 version of the PTSD-RI-5, as well as the first multisite study of an Asian population. This article presents psychometric characteristics of the PTSD-RI-5 derived from a sample of Japanese children and adolescents (N = 318). The PTSD-RI-5 total scale displayed good internal consistency reliability (α = 0...
March 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29536035/long-term-prognosis-and-recurrence-of-primary-sclerosing-cholangitis-after-liver-transplantation-a-single-center-experience
#7
Yoshihide Ueda, Toshimi Kaido, Hideaki Okajima, Koichiro Hata, Takayuki Anazawa, Atsushi Yoshizawa, Shintaro Yagi, Kojiro Taura, Toshihiko Masui, Noriyo Yamashiki, Hironori Haga, Miki Nagao, Hiroyuki Marusawa, Hiroshi Seno, Shinji Uemoto
Background: Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease, with liver transplantation being the sole life-saving treatment for end-stage PSC-related liver disease. However, recurrence of PSC after liver transplantation is a common complication, with the risk factors for recurrence being controversial. Methods: We conducted a retrospective chart review of 45 patients who had undergone liver transplantation for PSC at our institute...
December 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29529243/single-target-regulators-form-a-minor-group-of-transcription-factors-in-escherichia-coli-k-12
#8
Tomohiro Shimada, Hiroshi Ogasawara, Akira Ishihama
The identification of regulatory targets of all TFs is critical for understanding the entire network of the genome regulation. The lac regulon of Escherichia coli K-12 W3110 is composed of the lacZYA operon and its repressor lacI gene, and has long been recognized as the seminal model of transcription regulation in bacteria with only one highly preferred target. After the Genomic SELEX screening in vitro of more than 200 transcription factors (TFs) from E. coli K-12, however, we found that most TFs regulate multiple target genes...
May 4, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29528759/hemoadsorption-of-high-mobility-group-box-1-using-a-porous-polymethylmethacrylate-fiber-in-a-swine-acute-liver-failure-model
#9
Ryusuke Amemiya, Masahiro Shinoda, Masayuki Yamada, Yoshiyuki Ueno, Kaoru Shimada, Hiroaki Fujieda, Hiroshi Yagi, Takamasa Mizota, Ryo Nishiyama, Go Oshima, Shingo Yamada, Kentaro Matsubara, Yuta Abe, Taizo Hibi, Minoru Kitago, Hideaki Obara, Osamu Itano, Yuko Kitagawa
BACKGROUND: High-mobility-group box chromosomal protein 1 has been identified as an important mediator of various kinds of acute and chronic inflammation. In this study, we aimed to develop a column that effectively adsorbs high-mobility-group box chromosomal protein 1 by altering the pore size of the fiber. MATERIALS AND METHODS: First, we produced three types of porous polymethylmethacrylate fiber by altering the concentration of polymethylmethacrylate dissolved in dimethylsulfoxide...
April 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29501019/two-stage-resection-of-a-bilateral-pheochromocytoma-and-pancreatic-neuroendocrine-tumor-in-a-patient-with-von-hippel-lindau-disease-a-case-report
#10
Yutaka Endo, Minoru Kitago, Akira Miyajima, Isao Kurihara, Kaori Kameyama, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Chisato Takagi, Yutaka Nakano, Wataru Koizumi, Osamu Itano, Yuko Kitagawa
INTRODUCTION: von Hippel-Lindau disease (vHL disease) is a hereditary disease in which tumors and cysts develop in many organs, in association with central nervous system hemangioblastomas, pheochromocytomas, and pancreatic tumors. We herein report a case of vHL disease (type 2A) associated with bilateral pheochromocytomas, pancreatic neuroendocrine tumors (PNET), and cerebellar hemangioblastomas treated via pancreatectomy after adrenalectomy. CASE PRESENTATION: A 51-year-old woman presented with a cerebellar tumor, bilateral hypernephroma, and pancreatic tumor detected during a medical checkup...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29464203/rituximab-induction-to-prevent-the-recurrence-of-psc-after-liver-transplantation-the-lessons-learned-from-abo-incompatible-living-donor-liver-transplantation
#11
Yohei Yamada, Ken Hoshino, Yasushi Fuchimoto, Kentaro Matsubara, Taizo Hibi, Hiroshi Yagi, Yuta Abe, Masahiro Shinoda, Minoru Kitago, Hideaki Obara, Takahito Yagi, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto, Tatsuya Suzuki, Keiichi Kubota, Tomoharu Yoshizumi, Yoshihiko Maehara, Yukihiro Inomata, Yuko Kitagawa, Hiroto Egawa, Tatsuo Kuroda
Background: Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national study conducted in Japan revealed several risk factors for the recurrence after living donor LTx (LDLTx); however, recipients of ABO-blood type incompatible (ABO-I) LTx were excluded from the previous analysis. In the present study, we investigated the efficacy of an immunosuppressive protocol in ABO-I LTx on the recurrence of PSC after LDLTx...
February 2018: Transplantation Direct
https://www.readbyqxmd.com/read/29440671/impaired-airway-mucociliary-function-reduces-antigen-specific-iga-immune-response-to-immunization-with-a-claudin-4-targeting-nasal-vaccine-in-mice
#12
Hidehiko Suzuki, Takahiro Nagatake, Ayaka Nasu, Huangwenxian Lan, Koji Ikegami, Mitsutoshi Setou, Yoko Hamazaki, Hiroshi Kiyono, Kiyohito Yagi, Masuo Kondoh, Jun Kunisawa
Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted claudin-4, which is expressed by the epithelium associated with nasopharynx-associated lymphoid tissue (NALT), and could be effective as a nasal vaccine delivery. Mice lacking tubulin tyrosine ligase-like family, member 1 (Ttll1-KO mice) showed mucus accumulation in nasal cavity due to the impaired motility of respiratory cilia...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29423738/prognostic-factors-of-salvage-esophagectomy-for-residual-or-recurrent-esophageal-squamous-cell-carcinoma-after-definitive-chemoradiotherapy
#13
Yuki Kiyozumi, Naoya Yoshida, Takatsugu Ishimoto, Taisuke Yagi, Yuki Koga, Tomoyuki Uchihara, Hiroshi Sawayama, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Yuji Miyamoto, Masayuki Watanabe, Tomohiko Matsuyama, Natsuo Oya, Hideo Baba
BACKGROUND: The aim of this study was to confirm prognostic factors for salvage esophagectomy for remnant or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy. STUDY DESIGN: We retrospectively analyzed clinicopathological backgrounds of 50 patients who underwent salvage esophagectomy between April 2005 and January 2016. Salvage esophagectomy comprised 40 three-incision esophagectomies, two transhiatal esophagectomies and eight pharyngolaryngoesophagectomies...
February 8, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29394766/-two-cases-of-colorectal-cancer-with-src-amplification
#14
Hidehito Oyanagi, Yoshifumi Shimada, Ryoma Yagi, Yosuke Tajima, Hiroshi Ichikawa, Mae Nakano, Masato Nakano, Masayuki Nagahashi, Jun Sakata, Hitoshi Kameyama, Takashi Kobayashi, Hitoshi Nogami, Satoshi Maruyama, Yasumasa Takii, Toshifumi Wakai
Carcinoma with elevated SRC expression is associated with distant metastasis and drug resistance. We report 2 cases of SRC amplification observed after retrospective comprehensive genomic sequencing. Case 1 was a 62-year-old man who had RAS wild-type stage IV carcinoma of the sigmoid colon with multiple liver metastases in both lobes. He underwent low anterior resection and systemic chemotherapy was initiated to treat the unresectable multiple liver metastases. Case 2 was a 73-yearold man who had RAS wild-type stage IV carcinoma of the descending colon with metastasis in the lateral segment of the liver...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394680/-a-case-of-gastric-cancer-with-splenic-artery-aneurysm-intraoperative-icg-fluorography-is-useful-in-evaluating-the-blood-flow-of-stomach-and-spleen
#15
Kenji Usui, Kaoru Sakamoto, Kentaro Akabane, Kazuki Hayasaka, Toru Mizuki, Yutaka Yagi, Yasuhiro Shirahata, Hiroshi Ichikawa, Takaaki Hanyu, Takashi Ishikawa, Hitoshi Kameyama, Satoshi Suzuki, Kiyohiro Saito, Toshifumi Wakai
An 81-year-oldwoman with advancedgastric cancer was referredto our hospital. Preoperative contrast-enhancedCT revealeda roundcalcification of the splenic hilum with 15mm in diameter as a splenic artery aneurysm. She underwent transcatheter arterial embolization(TAE)for the splenic artery aneurysm. Celiac artery angiography showedcollateral arterial network of the spleen from left gastric artery. Surgery for the gastric cancer was performed1 4 days after TAE. We cut the right gastric andbilateral epigastric arteries...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394555/-a-case-of-ascending-colon-cancer-with-synchronous-liver-metastases-and-peritoneal-dissemination
#16
Masato Mito, Hitoshi Kameyama, Yoshifumi Shimada, Saki Yamada, Shinnosuke Hotta, Yuki Hirose, Ryoma Yagi, Yosuke Tajima, Mae Nakano, Takuma Okamura, Masato Nakano, Hiroshi Ichikawa, Masayuki Nagahashi, Jun Sakata, Toshifumi Wakai
The patient was a 73-year-old man with ascending colon cancer and synchronous liver metastases. A right hemicolectomy with a lymph node dissection was performed for the primary lesion. The resected specimen revealed a KRAS codon 12 mutation. After 6 courses of chemotherapy with capecitabine, oxaliplatin, and bevacizumab(Bv), we performed a partial hepatectomy and resection of the peritoneal dissemination. A computed tomography(CT)scan 5 months later revealed the recurrence of the liver metastases. After 8 courses of chemotherapy with 5-fluorouracil, Leucovorin, irinotecan, and Bv, we performed a partial hepatectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394541/-quality-of-life-of-patients-after-colorectal-cancer-surgery-as-assessed-using-eq-5d-5l-scores
#17
Hitoshi Kameyama, Yoshifumi Shimada, Ryoma Yagi, Saki Yamada, Shinnosuke Hotta, Yosuke Tajima, Mae Nakano, Takuma Okamura, Masato Nakano, Hiroshi Ichikawa, Takaaki Hanyu, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Toshifumi Wakai
This study aimed to evaluate the health-related quality of life(QOL)using EQ-5D-5L scores for patients who underwent surgery for colorectal cancer. A total of 30 consecutive patients(14 men and 16 women; median age: 67.5 years)from the outpatient clinic of our institute in January 2017 were eligible for this study. The primary tumor was located in the colon(n= 18)or rectum/anu(s n=12). Twelve patient(s 40.0%)had cancer recurrence, and 3 patient(s 10.0%)had a stoma. In addition, 11 patients(36.7%)underwent chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393154/long-interspersed-element-1-methylation-level-as-a-prognostic-biomarker-in-gastrointestinal-cancers
#18
Yoshifumi Baba, Taisuke Yagi, Hiroshi Sawayama, Yukiharu Hiyoshi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Epigenetic changes play a crucial role in human cancer development. DNA methylation is a central epigenetic process that regulates levels of gene expression. Changes in DNA methylation that occur in human tumors include global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Long interspersed element-1 (LINE-1) is a repetitive DNA retrotransposon that duplicates via a copy-and-paste genetic mechanism. As LINE-1 constitutes approximately 17% of the human genome, the extent of LINE-1 methylation is regarded as a surrogate marker of global DNA methylation...
2018: Digestion
https://www.readbyqxmd.com/read/29373148/effect-of-an-enhanced-recovery-after-surgery-protocol-in-patients-undergoing-pancreaticoduodenectomy-a-randomized-controlled-trial
#19
Kosei Takagi, Ryuichi Yoshida, Takahito Yagi, Yuzo Umeda, Daisuke Nobuoka, Takashi Kuise, Shiro Hinotsu, Takashi Matsusaki, Hiroshi Morimatsu, Jun Eguchi, Jun Wada, Masuo Senda, Toshiyoshi Fujiwara
BACKGROUND & AIMS: Evidence of the advantages of enhanced recovery after surgery (ERAS) protocols following pancreaticoduodenectomy (PD) is limited. The aim of this study was to examine the efficiency of ERAS protocols in patients following PD. METHODS: Between June 2014 and October 2016, patients undergoing PD were randomly assigned to receive ERAS protocols or standard care. The primary endpoint was the postoperative length of stay. Secondary endpoints included postoperative complications, postoperative quality-of-life (QoR-40J), readmission, and medical cost...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29366092/common-functional-variant-lipa-t16p-affects-hdl-composition-among-patients-with-heterozygous-familial-hypercholesterolemia
#20
Atushi Nohara, Masa-Aki Kawashiri, Yoshikatsu Eto, Miwa Fujisaki, Hayato Tada, Mie Yoshida, Mika Mori, Chiaki Nakanishi, Kunimasa Yagi, Akihiro Inazu, Masakazu Yamagishi, Hiroshi Mabuchi
No abstract text is available yet for this article.
August 2017: Atherosclerosis
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