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https://www.readbyqxmd.com/read/27920536/evaluation-of-potential-novel-variations-and-their-interactions-related-to-bipolar-disorders-analysis-of-genome-wide-association-study-data
#1
Cengizhan Acikel, Yesim Aydin Son, Cemil Celik, Husamettin Gul
BACKGROUND: Multifactor dimensionality reduction (MDR) is a nonparametric approach that can be used to detect relevant interactions between single-nucleotide polymorphisms (SNPs). The aim of this study was to build the best genomic model based on SNP associations and to identify candidate polymorphisms that are the underlying molecular basis of the bipolar disorders. METHODS: This study was performed on Whole-Genome Association Study of Bipolar Disorder (dbGaP [database of Genotypes and Phenotypes] study accession number: phs000017...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27920286/advanced-interatrial-block-and-ischemic-stroke-the-atherosclerosis-risk-in-communities-study
#2
Manuel Martinez-Selles, Adrian Baranchuk, Roberto Elosua, Antonio Bayés de Luna, Wesley T O'Neal, Hooman Kamel, Zhu-Ming Zhang, Lin Y Chen, Alvaro Alonso, Elsayed Z Soliman
No abstract text is available yet for this article.
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27919371/a-machine-learning-based-framework-to-identify-type-2-diabetes-through-electronic-health-records
#3
Tao Zheng, Wei Xie, Liling Xu, Xiaoying He, Ya Zhang, Mingrong You, Gong Yang, You Chen
OBJECTIVE: To discover diverse genotype-phenotype associations affiliated with Type 2 Diabetes Mellitus (T2DM) via genome-wide association study (GWAS) and phenome-wide association study (PheWAS), more cases (T2DM subjects) and controls (subjects without T2DM) are required to be identified (e.g., via Electronic Health Records (EHR)). However, existing expert based identification algorithms often suffer in a low recall rate and could miss a large number of valuable samples under conservative filtering standards...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27918907/prevalence-and-characteristics-of-cancer-patients-receiving-care-from-single-vs-multiple-institutions
#4
Christina A Clarke, Sally L Glaser, Rita Leung, Kathleen Davidson-Allen, Scarlett L Gomez, Theresa H M Keegan
INTRODUCTION: Patients may receive cancer care from multiple institutions. However, at the population level, such patterns of cancer care are poorly described, complicating clinical research. To determine the population-based prevalence and characteristics of patients seen by multiple institutions, we used operations data from a state-mandated cancer registry. METHODS AND MATERIALS: 59,672 invasive cancers diagnosed in 1/1/2010-12/31/2011 in the Greater Bay Area of northern California were categorized as having been reported to the cancer registry within 365days of diagnosis by: 1) ≥1 institution within an integrated health system (IHS); 2) IHS institution(s) and ≥1 non-IHS institution (e...
December 2, 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27917792/potential-beneficial-effects-of-foot-bathing-on-cardiac-rhythm
#5
Duygu Aydin, Siti Sugih Hartiningsih, Melike Gokce Izgi, Sevgi Bay, Kubra Unlu, Meryem Ozlem Tatar, Ayse Melike Alparslan, Mohammed Ozeri, Senol Dane
PURPOSE: Foot bathing therapy is a simple technique that induces sensations of comfort and relaxation. The aim of this study was to examine the effect of foot bathing therapy on heart rate variability (HRV) parameters in a healthy population. METHODS: Participants were twenty healthy female subjects (median age=20.67 years, SD=1.04). The recording ECG was applied for 5 minutes before and for 5 minutes after foot bathing therapy of 10 minutes. Subjects rested for 10 minutes without recording ECG in order to stabilize autonomic parameters...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27916454/computational-precision-of-mental-inference-as-critical-source-of-human-choice-suboptimality
#6
Jan Drugowitsch, Valentin Wyart, Anne-Dominique Devauchelle, Etienne Koechlin
Making decisions in uncertain environments often requires combining multiple pieces of ambiguous information from external cues. In such conditions, human choices resemble optimal Bayesian inference, but typically show a large suboptimal variability whose origin remains poorly understood. In particular, this choice suboptimality might arise from imperfections in mental inference rather than in peripheral stages, such as sensory processing and response selection. Here, we dissociate these three sources of suboptimality in human choices based on combining multiple ambiguous cues...
November 16, 2016: Neuron
https://www.readbyqxmd.com/read/27914556/numerical-likelihood-ratios-outputted-by-lr-systems-are-often-based-on-extrapolation-when-to-stop-extrapolating
#7
Peter Vergeer, Andrew van Es, Arent de Jongh, Ivo Alberink, Reinoud Stoel
A recent trend in forensic science is the development of objective, automated systems for the comparison of trace and reference material that give as output numerical likelihood ratios (LRs). For well discriminating LR systems, often the probability of the evidence given one or the other hypothesis depends on the density from the tail of a probability distribution. The models for probability distributions are trained by data. Since there is no proof of the applicability of the models beyond the data range, LR systems are sensitive to extrapolation errors...
December 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/27914398/the-acoustic-environment-of-inpatient-hospital-wards-in-the-united-kingdom
#8
Bridget Shield, Nicola Shiers, Rosemary Glanville
Many hospital noise surveys have shown that patients are subject to high levels of noise, in excess of current World Health Organization guidelines. Much of the previous research has focused on areas perceived to be noisy, such as intensive care units and operating theatres. This paper presents the results of a comprehensive noise survey of five general inpatient hospital wards in the UK. The survey involved continuous noise monitoring over several days, including identification of noise sources, in 31 locations representing a range of typical patient accommodations including single rooms and multi-bed bays, and nurse stations...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27913570/revisiting-the-human-polypeptide-galnac-t1-and-t13-paralogs
#9
María Florencia Festari, Felipe Trajtenberg, Nora Berois, Sergio Pantano, Leslie Revoredo, Yun Kong, Patricia Solari-Saquieres, Yoshiki Narimatsu, Teresa Freire, Sylvie Bay, Carlos Robello, Jean Bénard, Thomas A Gerken, Henrik Clausen, Eduardo Osinaga
Polypeptide GalNAc-transferases (GalNAc-Ts) constitute a family of 20 human glycosyltransferases (comprising 9 subfamilies), which initiate mucin-type O-glycosylation. The O-glycoproteome is thought to be differentially regulated via the different substrate specificities and expression patterns of each GalNAc-T isoforms. Here, we present a comprehensive in vitro analysis of the peptide substrate specificity of GalNAc-T13, showing that it essentially overlaps with the ubiquitous expressed GalNAc-T1 isoform found in the same subfamily as T13...
November 22, 2016: Glycobiology
https://www.readbyqxmd.com/read/27912914/distribution-and-source-analysis-of-heavy-metals-in-soils-and-sediments-of-yueqing-bay-basin-east-china-sea
#10
Xiaohui Yang, Pengbao Wu, Aijing Yin, Huan Zhang, Ming Zhang, Chao Gao
Concentrations of heavy metals in coastal soils, stream sediments and intertidal sediments of Yueqing Bay basin were analyzed to study their distribution and trace the possible sources. According to various single- and multi-index methods, heavy metal enrichment, especially for Cu, Zn, Cr and Ni in stream sediments, should draw environmental concern. Controlling factors such as inorganic scavengers, organic matter, sample grain size and hydrodynamic conditions were identified to influence the transportation and distribution of metals within coastal soils and sediments...
November 29, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27912823/-french-guidelines-and-pubmed-indexation
#11
EDITORIAL
Stéphane Vignot, Gilles L'Allemain, Jacques-Olivier Bay
No abstract text is available yet for this article.
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27911995/allometry-data-and-equations-for-coastal-marsh-plants
#12
Meng Lu, Joshua S Caplan, Jonathan D Bakker, J Adam Langley, Thomas J Mozdzer, Bert G Drake, J Patrick Megonigal
Coastal marshes are highly valued for ecosystem services such as protecting inland habitats from storms, sequestering carbon, removing nutrients and other pollutants from surface water, and providing habitat for fish, shellfish, and birds. Because plants largely determine the structure and function of coastal marshes, quantifying plant biomass is essential for evaluating these ecosystem services, understanding the biogeochemical processes that regulate ecosystem function, and forecasting tidal wetland responses to accelerated sea level rise...
December 2016: Ecology
https://www.readbyqxmd.com/read/27910769/anti-inflammatory-activity-of-biomass-extracts-of-the-bay-mushroom-imleria-badia-agaricomycetes-in-raw-264-7-cells
#13
Agata Grzywacz, Joanna Gdula Argasinska, Katarzyna Kala, Wlodzimierz Opoka, Bozena Muszynska
The popular edible bay mushroom, Imleria badia, is rich in phenolic and indole compounds, unsaturated fatty acids, and elements that have anti-inflammatory activity, including zinc. The aim of this study was to evaluate the pro- or anti-inflammatory impact of I. badia biomass extracts on RAW 264.7 cells. We analyzed the influence of I. badia extracts and/or lipopolysaccharide (LPS) cotreatment on the fatty acid profile of cell membranes. We also analyzed cyclooxygenase-2, prostaglandin E synthase, glutathione S transferase Mul, and nuclear factor (NF)-κB p50 and p65 protein expression, as well as the activity of peroxisome proliferator-activated receptor γ and NF-κB transcription factors...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27909942/experiment-design-for-nonparametric-models-based-on-minimizing-bayes-risk-application-to-voriconazole-formula-see-text
#14
David S Bayard, Michael Neely
An experimental design approach is presented for individualized therapy in the special case where the prior information is specified by a nonparametric (NP) population model. Here, a NP model refers to a discrete probability model characterized by a finite set of support points and their associated weights. An important question arises as to how to best design experiments for this type of model. Many experimental design methods are based on Fisher information or other approaches originally developed for parametric models...
December 1, 2016: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/27906453/syk-inhibition-blocks-airway-constriction-and-protects-from-th2-induced-airway-inflammation-and-remodeling-in-mice
#15
Christoph Tabeling, Julia Herbert, Andreas C Hocke, David Lamb, Lutz Wollin, Klaus Erb, Ekaterina Boiarina, Hesam Movassagh, Jörg Scheffel, Jan M Doehn, Stefan Hippenstiel, Marcus Maurer, Abdelilah S Gounni, Wolfgang M Kuebler, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Spleen tyrosine kinase (Syk) is an intracellular non-receptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk inhibition on airway constriction independent of allergen sensitization remain elusive. METHODS: Spectral confocal microscopy of human and murine lung tissue was performed to localize Syk expression...
December 1, 2016: Allergy
https://www.readbyqxmd.com/read/27906237/diode-pumped-laser-operation-of-pr-sup-3-sup-ba-y-sub-0-8-sub-lu-sub-0-2-sub-sub-2-sub-f-sub-8-sub-in-the-visible-region
#16
Alberto Sottile, Eugenio Damiano, Mauro Tonelli
We report on, to the best of our knowledge, the first growth, spectroscopy, and laser operation of monocrystalline Ba(Y<sub>0.8</sub>Lu<sub>0.2</sub>)<sub>2</sub>F<sub>8</sub> doped with 1.25 at.% of Pr<sup>3+</sup> ions (Pr:BYLF). We studied the spectroscopic properties of this material, particularly in comparison with its isomorph Pr<sup>3+</sup>: BaY<sub>2</sub>F<sub>8</sub> (Pr:BYF). Under diode-pumped excitation, we achieved continuous-wave laser operation in the orange, red, and deep red regions in the three possible crystal orientations...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27905045/differential-response-of-coral-communities-to-caulerpa-spp-bloom-in-the-reefs-of-indian-ocean
#17
B Manikandan, J Ravindran
Coral reef ecosystems are disturbed in tandem by climatic and anthropogenic stressors. A number of factors act synergistically to reduce the live coral cover and threaten the existence of reefs. Continuous monitoring of the coral communities during 2012-2014 captured an unprecedented growth of macroalgae as a bloom at Gulf of Mannar (GoM) and Palk Bay (PB) which are protected and unprotected reefs, respectively. The two reefs varying in their protection level enabled to conduct an assessment on the response of coral communities and their recovery potential during and after the macroalgal bloom...
December 1, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27904807/pathogen-reduction-co-benefits-of-nutrient-best-management-practices
#18
Jennifer Richkus, Lisa A Wainger, Mary C Barber
BACKGROUND: Many of the practices currently underway to reduce nitrogen, phosphorus, and sediment loads entering the Chesapeake Bay have also been observed to support reduction of disease-causing pathogen loadings. We quantify how implementation of these practices, proposed to meet the nutrient and sediment caps prescribed by the Total Maximum Daily Load (TMDL), could reduce pathogen loadings and provide public health co-benefits within the Chesapeake Bay system. METHODS: We used published data on the pathogen reduction potential of management practices and baseline fecal coliform loadings estimated as part of prior modeling to estimate the reduction in pathogen loadings to the mainstem Potomac River and Chesapeake Bay attributable to practices implemented as part of the TMDL...
2016: PeerJ
https://www.readbyqxmd.com/read/27904802/abundance-and-physiology-of-dominant-soft-corals-linked-to-water-quality-in-jakarta-bay-indonesia
#19
Gunilla Baum, Indra Januar, Sebastian C A Ferse, Christian Wild, Andreas Kunzmann
Declining water quality is one of the main reasons of coral reef degradation in the Thousand Islands off the megacity Jakarta, Indonesia. Shifts in benthic community composition to higher soft coral abundances have been reported for many degraded reefs throughout the Indo-Pacific. However, it is not clear to what extent soft coral abundance and physiology are influenced by water quality. In this study, live benthic cover and water quality (i.e. dissolved inorganic nutrients (DIN), turbidity (NTU), and sedimentation) were assessed at three sites (< 20 km north of Jakarta) in Jakarta Bay (JB) and five sites along the outer Thousand Islands (20-60 km north of Jakarta)...
2016: PeerJ
https://www.readbyqxmd.com/read/27902843/ridge-estimation-of-the-var-1-model-and-its-time-series-chain-graph-from-multivariate-time-course-omics-data
#20
Viktorian Miok, Saskia M Wilting, Wessel N van Wieringen
Omics experiments endowed with a time-course design may enable us to uncover the dynamic interplay among genes of cellular processes. Multivariate techniques (like VAR(1) models describing the temporal and contemporaneous relations among variates) that may facilitate this goal are hampered by the high-dimensionality of the resulting data. This is resolved by the presented ridge regularized maximum likelihood estimation procedure for the VAR(1) model. Information on the absence of temporal and contemporaneous relations may be incorporated in this procedure...
November 7, 2016: Biometrical Journal. Biometrische Zeitschrift
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