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https://www.readbyqxmd.com/read/29330405/better-outcome-with-haploidentical-over-hla-matched-related-donors-in-patients-with-hodgkin-s-lymphoma-undergoing-allogeneic-haematopoietic-cell-transplantation-a-study-by-the-francophone-society-of-bone-marrow-transplantation-and-cellular-therapy
#1
Jordan Gauthier, Xavier Poiré, Anne-Claire Gac, Mathieu Leclerc, Thierry Guillaume, Yves Chalandon, Stéphanie Nguyen, Edouard Forcade, Caroline Régny, Jacques-Olivier Bay, Ali Bazarbachi, Pierre-Simon Rohrlich, Anne Huynh, Jonathan Farhi, Tony Marchand, Jean-Valère Malfuson, Sylvain Pilorge, Hélène Labussière-Wallet, Cécile Renard, Luc-Matthieu Fornecker, Marie Detrait, Rémy Duléry, Jérémy Delage, Anne-Lise Ménard, Amandine Charbonnier, Brigitte Nelken, Charlotte Jubert, Felipe Suarez, Régis Peffault de la Tour, Yves Beguin, Hélène Schoemans, Didier Blaise, Ibrahim Yakoub-Agha
The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. We analysed the data of 151 consecutive HL patients who underwent NMA or RIC allo-HCT from a HAPLO (N  =  61) or MRD (N  =  90) between January 2011 and January 2016...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29329385/reassessing-the-evidence-for-capacity-limits-in-neural-signals-related-to-working-memory
#2
Paul M Bays
In 2004, two landmark studies described the discovery of brain imaging (functional magnetic resonance imaging and electroencephalography) signals that increase with the number of items held in visual working memory (WM). These studies claimed that the signals leveled off (plateaued) once the number of memoranda reached the capacity of WM, as estimated by the prevailing model of the time. However, alternative models were not considered, and changing concepts of WM in the more than a decade since these studies were published necessitate a re-evaluation of their findings; newer models that provide the most accurate account of behavioral data do not incorporate a fixed limit on the number of items stored...
January 10, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29327266/social-targets-improve-body-based-and-environment-based-strategies-during-spatial-navigation
#3
Esther Kuehn, Xiaoli Chen, Pia Geise, Jan Oltmer, Thomas Wolbers
Encoding the position of another person in space is vital for everyday life. Nevertheless, little is known about the specific navigational strategies associated with encoding the position of another person in the wider spatial environment. We asked two groups of participants to learn the location of a target (person or object) during active navigation, while optic flow information, a landmark, or both optic flow information and a landmark were available in a virtual environment. Whereas optic flow information is used for body-based encoding, such as the simulation of motor movements, landmarks are used to form an abstract, disembodied representation of the environment...
January 11, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29327195/long-term-variations-of-the-riverine-input-of-potentially-toxic-dissolved-elements-and-the-impacts-on-their-distribution-in-jiaozhou-bay-china
#4
Changyou Wang, Jinqiang Guo, Shengkang Liang, Yunfei Wang, Yanqun Yang, Xiulin Wang
The concentrations of the potentially toxic dissolved elements (PTEs) As, Hg, Cr, Pb, Cd, and Cu in the main rivers into Jiaozhou Bay (JZB) during 1981-2006 were measured, and the impact of the fluvial PTE fluxes on their distributions in the bay was investigated. The overall average concentration in the rivers into JZB ranged from 8.8 to 39.6 μg L-1 for As, 10.1 to 632.6 ng L-1 for Hg, 4.1 to 3003.6 μg L-1 for Cr, 8.5 to 141.9 μg L-1 for Pb, 1.1 to 34.2 μg L-1 for Cd, and 13.2 to 1042.8 μg L-1 for Cu...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29327015/a-water-soluble-bay-functionalized-perylenediimide-derivative-correlating-aggregation-and-excited-state-dynamics
#5
K Dirian, S Bauroth, A Roth, Z Syrgiannis, F Rigodanza, M Burian, H Amenitsch, D I Sharapa, M Prato, T Clark, D M Guldi
The aggregation and the photophysics of a water soluble perylenediimide (PDI) derivative that features two bromine substituents in the bay positions has been probed. Non-fluorescent aggregates were found to be present at concentrations of 1.0 × 10-5 M. In situ small-angle X-ray scattering (SAXS) measurements and complementary molecular modeling showed the presence of PDI aggregates. In their singlet excited states, the PDI aggregates are characterized by distinct transient fingerprints and rapid deactivation, as revealed by pump-probe experiments on the femto-, pico-, nano-, and microsecond timescales...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29325451/expression-of-sestrin-genes-in-radiotherapy-for-prostate-cancer-and-its-association-with-fatigue-a-proof-of-concept-study
#6
Velda J Gonzalez, Farnoosh Abbas-Aghababazadeh, Brooke L Fridley, Tomar Ghansah, Leorey N Saligan
Genetic factors that influence inflammation and energy production/expenditure in cells may affect patient outcomes following treatment with external beam radiation therapy (EBRT). Sestrins, stress-inducible genes with antioxidant properties, have recently been implicated in several behaviors including fatigue. This proof-of-concept study explored whether the sestrin family of genes ( SESN1, SESN2, and SESN3) were differentially expressed from baseline to the midpoint of EBRT in a sample of 26 Puerto Rican men with nonmetastatic prostate cancer...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29324295/analytical-determination-of-the-reducing-and-stabilization-agents-present-in-different-zostera-noltii-extracts-used-for-the-biosynthesis-of-gold-nanoparticles
#7
Rafael Zarzuela, Manuel Jesús Luna, María Luisa Almoraima Gil, María Jesús Ortega, José María Palacios-Santander, Ignacio Naranjo-Rodríguez, Juan José Delgado, Laura María Cubillana-Aguilera
The objective of this work was to ascertain the nature of the components responsible for the reducing and stabilizing properties of Zostera noltii extracts that lead to gold nanoparticle formation using chemical techniques of analysis. In order to achieve this aim, we try the synthesis of AuNPs with three different extracts from plants collected in the Bay of Cádiz (Spain). The n-butanol extract produced the best results. Taking this into account, four fractions were isolated by Sephadex LH-20 column chromatography from this extract and we studied their activity...
December 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29324292/use-of-sperm-dna-integrity-as-a-marker-for-exposure-to-contamination-in-palaemon-serratus-pennant-1777-intrinsic-variability-baseline-level-and-in-situ-deployment
#8
Alexandre Erraud, Marc Bonnard, Arnaud Chaumot, Olivier Geffard, Aurélie Duflot, Joëlle Forget-Leray, Frank Le Foll, Alain Geffard, Benoit Xuereb
In a previous study, the Comet assay was optimized for Palaemon serratus prawns in order to propose a biomarker for sperm quality in this species. However, better knowledge of its basal level and its natural variability, related to intrinsic biotic and environmental abiotic factors, is required before any relevant use of this biomarker in the field. To fulfill this goal, the present study proceeded in three steps: (i) the temporal variability of DNA integrity was followed monthly in a reference population over a 2-year period, (ii) the correlation between the main intrinsic biotic (i...
December 27, 2017: Water Research
https://www.readbyqxmd.com/read/29323152/unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#9
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
Mechanical conditioning is incompletely characterized for stimulating therapeutic cells within the physiological range. We sought to unravel the mechanism of action underlying mechanical conditioning of adipose tissue-derived progenitor cells (ATDPCs), both in vitro and in silico. Cardiac ATDPCs, grown on 3 different patterned surfaces, were mechanically stretched for 7 days at 1 Hz. A custom-designed, magnet-based, mechanical stimulator device was developed to apply ~10% mechanical stretching to monolayer cell cultures...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322688/phylodynamics-of-classical-swine-fever-virus-with-emphasis-on-ecuadorian-strains
#10
A D Garrido Haro, M Barrera Valle, A Acosta, F J Flores
Classic swine fever virus (CSFV) is a Pestivirus from the Flaviviridae family that affects pigs worldwide and is endemic in several Latin American countries. However, there are still some countries in the region, including Ecuador, for which CSFV molecular information is lacking. To better understand the epidemiology of CSFV in the Americas, sequences from CSFVs from Ecuador were generated and a phylodynamic analysis of the virus was performed. Sequences for the full-length glycoprotein E2 gene of twenty field isolates were obtained and, along with sequences from strains previously described in the Americas and from the most representative strains worldwide, were used to analyse the phylodynamics of the virus...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29322097/toward-a-leading-indicator-of-catastrophic-shifts-in-complex-systems-assessing-changing-conditions-in-nation-states
#11
Leisha Vance, Tarsha Eason, Heriberto Cabezas, Michael E Gorman
The 20th century was characterized by substantial change on a global scale. There were multiple wars and unrest, social and political transitions, technological innovation and widespread development that impacted every corner of the earth. In order to assess the sustainability implications of these changes, we conducted a study of three advanced nations particularly affected during this time: France, Germany and the United States (USA). All three nation states withstood these changes and yet continued to thrive, which speaks to their resilience...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29321867/high-site-fidelity-and-restricted-ranging-patterns-in-southern-australian-bottlenose-dolphins
#12
Cecilia Passadore, Luciana Möller, Fernando Diaz-Aguirre, Guido J Parra
Information on site fidelity and ranging patterns of wild animals is critical to understand how they use their environment and guide conservation and management strategies. Delphinids show a wide variety of site fidelity and ranging patterns. Between September 2013 and October 2015, we used boat-based surveys, photographic identification, biopsy sampling, clustering analysis, and geographic information systems to determine the site-fidelity patterns and representative ranges of southern Australian bottlenose dolphins (Tursiops cf...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29319647/transition-to-critical-care-practice-within-an-academic-service-partnership-a-case-report-of-the-first-3-years-of-clinical-immersion-in-trauma-burn-and-neuroscience-critical-care
#13
Esther Bay, Andrea Sherzer, Emily Darnbrook
In response to regulators of nursing education and the Institute of Medicine, an academic-service partnership was formed between a research-intensive school of nursing and a tertiary health care facility. In that partnership, clinical experiences occurred mostly within 1 organization. This case report showcases the development, implementation, and revisions within our capstone immersion course, designed to ease the new graduates' transition into practice, including transitions to critical care nursing. Herein, we highlight our successes and challenges of implementing the clinical component within 2 critical care units focused on trauma and neurosurgical care of complex patients...
January 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29316861/cultures-of-caring-healthcare-scandals-inquiries-and-the-remaking-of-accountabilities
#14
Dawn Goodwin
In the UK, a series of high-profile healthcare 'scandals' and subsequent inquiries repeatedly point to the pivotal role culture plays in producing and sustaining healthcare failures. Inquiries are a sociotechnology of accountability that signal a shift in how personal accountabilities of healthcare professionals are being configured. In focusing on problematic organizational cultures, these inquiries acknowledge, make visible, and seek to distribute a collective responsibility for healthcare failures. In this article, I examine how the output of one particular inquiry - The Report of the Morecambe Bay Investigation - seeks to make culture visible and accountable...
January 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29316784/clusterin-induces-muc5ac-expression-via-activation-of-nf-%C3%AE%C2%BAb-in-human-airway-epithelial-cells
#15
Chang Hoon Bae, Hyung Gyun Na, Yoon Seok Choi, Si-Youn Song, Yong-Dae Kim
Objectives: Clusterin (CLU) is known as apolipoprotein J, and has three isoforms with different biological functions. CLU is associated with various diseases such as Alzheimer disease, atherosclerosis, and some malignancies. Recent studies report an association of CLU with inflammation and immune response in inflammatory airway diseases. However, the effect of CLU on mucin secretion of airway epithelial cells has not yet been understood. Therefore, the effect and brief signaling pathway of CLU on MUC5AC (as a major secreted mucin) expression were investigated in human airway epithelial cells...
January 11, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29316521/aox-contamination-in-hangzhou-bay-china-levels-distribution-and-point-sources
#16
Ya-Wei Xie, Lu-Jun Chen, Rui Liu, Jin-Ping Tian
The parameter AOX (adsorbable organic halogens) indicates the total amount of organic halogens in an environment. Seawater and surface sediment samples from 12 sample sites in the Hangzhou Bay (HZB), China, were analyzed for AOX to investigate its contamination status. In this study, the AOX concentration ranged from 140.6 ± 45.6 μg/L to 716.1 ± 62.3 μg/L in seawater of the HZB, and from 11.3 ± 2.4 mg/kg to 112.7 ± 7.2 mg/kg in the sediment. Ocean currents, fluvial currents and the Yangtze River exerted profound influences on the distribution of AOX in the HZB...
January 6, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29316466/metal-complexation-capacity-of-antarctic-lacustrine-sediments
#17
Giancarla Alberti, Matteo Mussi, Federico Quattrini, Maria Pesavento, Raffaela Biesuz
The purpose of this study is to implement a work that is a part of a project funded by the Italian National Antarctic Research Program (PNRA, Piano Nazionale di Ricerche in Antartide) within the main thematic focus "Chemical Contamination-Global Change". This research was devoted to detect and characterize micro and nano components with strong complexing capability towards metal ions at trace level in sea water, lakes and lacustrine sediments, sampled during the XXII expedition of PNRA. In particular, in the present work, the sorption complexation capacity of an Antarctic lacustrine sediments toward Cu(II) and Pb(II) is described...
December 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29315458/implementation-and-effectiveness-of-a-video-based-debriefing-programme-for-neonatal-resuscitation
#18
C Skåre, T E Calisch, E Saeter, T Rajka, A M Boldingh, B Nakstad, D E Niles, J Kramer-Johansen, T M Olasveengen
BACKGROUND: Approximately 5%-10% of newly born babies need intervention to assist transition from intra- to extrauterine life. All providers in the delivery ward are trained in neonatal resuscitation, but without clinical experience or exposure, training competency is transient with a decline in skills within a few months. The aim of this study was to evaluate whether neonatal resuscitations skills and team performance would improve after implementation of video-assisted, performance-focused debriefings...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29314092/bayesian-analysis-of-multimethod-ego-depletion-studies-favours-the-null-hypothesis
#19
Joseph L Etherton, Randall Osborne, Katelyn Stephenson, Morgan Grace, Chas Jones, Alessandro De Nadai
Ego-depletion refers to the purported decrease in performance on a task requiring self-control after engaging in a previous task involving self-control, with self-control proposed to be a limited resource. Despite many published studies consistent with this hypothesis, recurrent null findings within our laboratory and indications of publication bias have called into question the validity of the depletion effect. This project used three depletion protocols involved three different depleting initial tasks followed by three different self-control tasks as dependent measures (total n = 840)...
January 4, 2018: British Journal of Social Psychology
https://www.readbyqxmd.com/read/29311420/computer-aided-diagnosis-of-lung-cancer-the-effect-of-training-datasets-on-classification-accuracy-of-lung-nodules
#20
Jing Gong, Ji-Yu Liu, Xi-Wen Sun, Bin Zheng, Sheng-Dong Nie
This study aims to develop a computer-aided diagnosis (CADx) scheme for classification between malignant and benign lung nodules, and also assess whether CADx performance changes in detecting nodules associated with early and advanced stage lung cancer. Methods: The study involves 243 biopsy-confirmed pulmonary nodules. Among them, 76 are benign, 81 are stage I and 86 are stage III malignant nodules. Cases are partitioned into 3 datasets involving: (1) all nodules, (2) benign and stage I malignant nodules, and (3) benign and stage III malignant nodules...
January 9, 2018: Physics in Medicine and Biology
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