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https://www.readbyqxmd.com/read/29447790/fine-particulate-matter-and-incident-coronary-heart-disease-in-the-regards-cohort
#1
Matthew Shane Loop, Leslie A McClure, Emily B Levitan, Mohammad Z Al-Hamdan, William L Crosson, Monika M Safford
Chronic exposure to fine particulate matter (PM 2.5 ) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of the effect of chronic exposure to PM 2.5 on risk for CHD do not generalize to more diverse samples. METHODS: Therefore, we estimated the relationship between chronic exposure to PM 2...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447733/stroke-risk-in-patients-with-reduced-ejection-fraction-after-myocardial-infarction-without-atrial-fibrillation
#2
João Pedro Ferreira, Nicolas Girerd, John Gregson, Ichraq Latar, Abhinav Sharma, Marc A Pfeffer, John J V McMurray, Azmil H Abdul-Rahim, Bertram Pitt, Kenneth Dickstein, Patrick Rossignol, Faiez Zannad
BACKGROUND: Stroke can occur after myocardial infarction (MI) in the absence of atrial fibrillation (AF). OBJECTIVES: This study sought to identify risk factors (excluding AF) for the occurrence of stroke and to develop a calibrated and validated stroke risk score in patients with MI and heart failure (HF) and/or systolic dysfunction. METHODS: The datasets included in this pooling initiative were derived from 4 trials: CAPRICORN (Effect of Carvedilol on Outcome After Myocardial Infarction in Patients With Left Ventricular Dysfunction), OPTIMAAL (Optimal Trial in Myocardial Infarction With Angiotensin II Antagonist Losartan), VALIANT (Valsartan in Acute Myocardial Infarction Trial), and EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study); EPHESUS was used for external validation...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29446510/use-of-t-1-relaxation-time-in-rotating-frame-t-1-%C3%AF-and-apparent-diffusion-coefficient-to-estimate-cerebral-stroke-evolution
#3
Yuefa Tan, Jun Xu, Ruiying Chen, Bin Chen, Juan Xu, Daokun Ren, Queenie Chan, Yingjie Mei, Yuankui Wu, Yikai Xu
BACKGROUND: The major factor for the appropriate treatment strategies for ischemia patients is its onset timing. PURPOSE/HYPOTHESIS: To study to evaluate the diagnostic accuracy of T 1 relaxation time in a rotating frame (T 1 ρ) and apparent diffusion coefficient (ADC) from MRI to estimate ischemia stages. STUDY TYPE: Prospective. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: In all, 73 patients (49 males, aged 29-78 years and 24 females, aged 22-94 years) with ischemia were prospectively imaged with T 1 ρ and diffusion MRI during the postischemic period...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29445436/steroid-responsive-encephalopathy-associated-with-autoantibodies-to-thyroperoxidase-streat-presenting-with-acute-stroke-in-a-young-female-patient
#4
Eman Salah Heikal, Alshimaa Shaban Othman, Foad Abd-Allah
No abstract text is available yet for this article.
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445435/investigation-of-gender-differences-and-exclusive-criteria-in-a-diabetic-acute-ischemic-stroke-population-treated-with-recombinant-tissue-type-plasminogen-activator-rtpa
#5
Taylor Wapshott, Brice Blum, Williams Kelsey, Thomas I Nathaniel
Background: Many studies have reported that women who survive stroke have less favorable outcomes than men in the use of rtPA, while others reported worse outcomes in men than women. The gender difference in the exclusion criteria in a diabetic stroke population is not fully understood. This issue was investigated in this study. Method: In a diabetic stroke population from a stroke registry of data collected between January 2010 to June 30, 2016, the gender difference was determined using demographics and clinical factors...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445431/outcome-recurrence-and-mortality-after-non-valvular-atrial-fibrillation-stroke-long-term-follow-up-study
#6
Antonio Arauz, Francisco Ruiz-Navarro, Miguel A Barboza, Angelica Ruiz, Jonathan Colin, Marisela Reyes, Humberto Silos, Carlos Cantu-Brito, Luis Murillo-Bonilla, Fernando Barinagarrementeria
Objective: Non-valvular atrial fibrillation (NVAF) is a major risk factor for ischemic stroke (IS) and a powerful predictor of mortality. This study investigates early and long-term outcome among patients with IS secondary to NVAF and identify the main factors associated with poor outcome, recurrence, and death. Methods: We analyzed the data from our consecutive NVAF acute IS database, over a period of 23 years. The endpoints were bad outcome (Modified Rankin Score ≥3), recurrence, and mortality at discharge, after 6 months, 12 months, and final follow-up...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29440356/arterial-diameter-and-the-gender-disparity-in-stroke-thrombectomy-outcomes
#7
Mark A Davison, Bichun Ouyang, Kavantissa M Keppetipola, Michael Chen
BACKGROUND: Compared with males, females consistently fare worse following mechanical thrombectomy for large vessel ischemic strokes. Understanding why this gender disparity occurs may guide improvements in future treatment strategies. In this study, we aim to determine whether gender differences in cerebral arterial diameter correlate with clinical outcomes following stroke thrombectomy. METHODS: We performed an observational study of consecutive acute ischemic stroke patients undergoing mechanical thrombectomy at a single, urban tertiary care medical center...
February 12, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29439160/co-occurrence-of-depressive-symptoms-and-executive-dysfunction-after-stroke-associations-with-brain-pathology-and-prognosis
#8
Elles Douven, Pauline Aalten, Julie Staals, Syenna H J Schievink, Robert J van Oostenbrugge, Frans R J Verhey, Sebastian Köhler
OBJECTIVE: To examine, first, whether the co-occurrence of executive dysfunction (ED) and poststroke depression (PSD) shows different associations with neuroimaging markers and the course of depression and executive function, and second, whether it is associated with a different course on other cognitive domains and quality of life. METHODS: The present study included 245 stroke patients (35.9% female, mean age 67.5 years (SD=11.9). All patients completed neuropsychological and neuropsychiatric assessment 3 months poststroke, which were repeated at 6-month and 12-month follow-up...
February 8, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29438418/bile-acid-detoxifying-enzymes-limit-susceptibility-to-liver-fibrosis-in-female-shrsp5-dmcr-rats-fed-with-a-high-fat-cholesterol-diet
#9
Husna Yetti, Hisao Naito, Yuan Yuan, Xiaofang Jia, Yumi Hayashi, Hazuki Tamada, Kazuya Kitamori, Katsumi Ikeda, Yukio Yamori, Tamie Nakajima
During middle age, women are less susceptible to nonalcoholic steatohepatitis (NASH) than men. Thus, we investigated the underlying molecular mechanisms behind these sexual differences using an established rat model of NASH. Mature female and male stroke-prone spontaneously hypertensive 5/Dmcr rats were fed control or high-fat-cholesterol (HFC) diets for 2, 8, and 14 weeks. Although HFC-induced hepatic fibrosis was markedly less severe in females than in males, only minor gender differences were observed in expression levels of cytochrome P450 enzymes (CYP)7A1, CYP8B1 CYP27A1, and CYP7B1, and multidrug resistance-associated protein 3, and bile salt export pump, which are involved in fibrosis-related bile acid (BA) kinetics...
2018: PloS One
https://www.readbyqxmd.com/read/29436126/aerobic-exercise-prior-to-task-specific-training-to-improve-poststroke-motor-function-a-case-series
#10
S R Valkenborghs, M M Visser, M Nilsson, R Callister, P van Vliet
BACKGROUND: Aerobic exercise can improve upper limb motor function in both healthy and stroke populations. Research in animals after stroke has shown that aerobic exercise combined with forelimb motor training improved forelimb motor function more than aerobic exercise or motor training alone. There is a lack of knowledge about this combined intervention in humans after stroke. PURPOSE: These 2 case reports describe the exploratory implementation of a combined aerobic exercise and task-specific training intervention to improve upper limb motor function in one person in subacute stroke recovery and one person in chronic stroke recovery...
February 13, 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29434480/a-rare-presentation-of-neuromyelitis-optica-spectrum-disorders
#11
Navneet K Singh, Alexander J Sweidan, Sarah Strube, Ignacio Carrillo-Nunez
Neuromyelitis optica spectrum disorders (NMOSDs) are a set of demyelinating disorders that primarily target the optic nerves and the spinal cord. Previously thought to be a subset of multiple sclerosis (MS), now is recognized as a distinct entity. We present a 59-year-old female patient who was admitted for acute upper and lower extremity weakness. The patient had woken up from sleep with sudden onset of weakness. Patient was initially diagnosed with a right hemispheric stroke; however, magnetic resonance imaging of the cervical spine later performed showed abnormal enhancement from C2-C4, representing transverse myelitis...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29434154/the-clinical-features-of-ischemic-stroke-patients-for-whom-smoking-was-considered-the-sole-risk-factor-for-ischemic-stroke
#12
Takuya Fukuoka, Yoshihiko Nakazato, Hitoshi Kawasaki, Kei Ikeda, Tomotsugu Furuya, Akifumi Miyake, Takashi Mitsufuji, Yasuo Ito, Kazushi Takahashi, Nobuo Araki, Norio Tahahashi, Toshimasa Yamamoto
Objective The purpose of this study was to clarify the clinical features of ischemic patients for whom cigarette smoking was the sole risk factor for ischemic stroke. Methods Among the 1,329 patients (male, n=833; female, n=496) with acute ischemic stroke who were admitted to our hospital between April 2005 and September 2016, 346 (26%) were smokers (male, n=308 [36.9%]; female, 38 [7.6%]). In 42 (3.1%; male, n=41; female, n=1) cases, cigarette smoking was considered to be the sole risk factor for ischemic stroke...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432125/clinical-and-patient-centered-outcomes-in-obese-type-2-diabetes-patients-3-years-after-randomization-to-roux-en-y-gastric-bypass-surgery-versus-intensive-lifestyle-management-the-slimm-t2d-study
#13
Donald C Simonson, Florencia Halperin, Kathleen Foster, Ashley Vernon, Allison B Goldfine
OBJECTIVE: To compare the effect of Roux-en-Y gastric bypass (RYGB) surgery versus intensive medical diabetes and weight management (IMWM) on clinical and patient-reported outcomes in obese patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We prospectively randomized 38 obese patients with T2D (15 male and 23 female, with mean ± SD weight 104 ± 16 kg, BMI 36.3 ± 3.4 kg/m2, age 52 ± 6 years, and HbA1c 8.5 ± 1.3% [69 ± 14 mmol/mol]) to laparoscopic RYGB (n = 19) or IMWM (n = 19)...
February 6, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29431623/prevalence-and-risk-factors-for-venous-thromboembolism-in-children-with-sickle-cell-disease-an-administrative-database-study
#14
Riten Kumar, Joseph Stanek, Susan Creary, Amy Dunn, Sarah H O'Brien
A hypercoagulable state resulting in increased venous thromboembolism (VTE) has been described in adults with sickle cell disease (SCD), but similar data for children are lacking. The objective of this retrospective cohort study was to describe the rate of VTE and risk factors associated with VTE in children with SCD across tertiary-care children's hospitals in the United States between the years 2009 and 2015. We used the Pediatric Health Information System database to investigate all pediatric patients with SCD admitted to 1 of 48 participating institutions between 1 January 2009 and 30 September 2015...
February 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29431592/in-season-changes-in-ventricular-morphology-and-systolic-function-in-adolescent-female-athletes
#15
Andrew M Watson, Carol Coutinho, Kristin Haraldsdottir, Stacey Brickson, Warren Dunn, Marlowe Eldridge
PURPOSE: To evaluate the influence of physical maturity on the changes in ventricular morphology and function with sport training in female youth athletes. METHODS: Thirty-two female athletes (age 13-18 years) underwent height and weight measurement and 2-D echocardiographic evaluation immediately prior to, and following, a 20-week soccer season. Pre- and post-season left ventricular end-diastolic diameter (LVEDD), end-diastolic volume (LVEDV), ejection fraction (LVEF), stroke volume (LVSV), mass (LVM), and posterior wall thickness (LVPWT), right ventricular end-diastolic diameter (RVEDD), end-diastolic area (RVEDA), and fractional area change (RVFAC), and interventricular septal thickness (IVST) were compared...
February 12, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29430236/idiopathic-thrombocytopenia-purpura-masking-hodgkin-disease-a-paraneoplastic-syndrome-or-simply-a-mere-association
#16
Nicholas Poponea, Mohanad Suede, Mohammad Muhsin Chisti
We report a 74-year-old female who presented to the emergency department complaining of bruising and stroke-like symptoms. She underwent a negative stroke work-up but was found to have profoundly low platelets and splenomegaly on examination. An abdominal CT scan was ordered, showing pelvic lymphadenopathy. Lymphoma was suspected. However, subsequent bone marrow and lymph node biopsies showed no evidence of this. She was treated for immune thrombocytopenia purpura (ITP) to no avail while a lymphoma work-up continued...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29428327/the-effect-of-being-found-with-stroke-symptoms-on-predictors-of-hospital-arrival
#17
Mellanie V Springer, Daniel L Labovitz
BACKGROUND: Studies examining predictors of delay in hospital arrival after stroke symptom onset have not accounted for patients who are found with their symptoms and cannot seek help independently. Our objective is to show that inclusion of patients who are "found down" in studies of prehospital delay biases the estimated association of sociodemographic and clinical variables with time of hospital arrival. METHODS: We performed a retrospective analysis of sociodemographic and clinical characteristics of patients with acute ischemic stroke presenting to a tertiary care hospital in the Bronx, New York...
February 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29427504/chronic-physical-conditions-multimorbidity-and-mild-cognitive-impairment-in-low-and-middle-income-countries
#18
Ai Koyanagi, Elvira Lara, Brendon Stubbs, Andre F Carvalho, Hans Oh, Andrew Stickley, Nicola Veronese, Davy Vancampfort
OBJECTIVES: To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). DESIGN: Nationally representative, cross-sectional, community-based study. SETTING: Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health. PARTICIPANTS: Individuals aged 50 and older (N=32,715; mean age 62...
February 10, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29424477/association-of-lipoprotein-associated-phospholipase-a2-mass-with-asymptomatic-cerebral-artery-stenosis
#19
Youxin Wang, Bin Zhou, Pingan Zhou, Yan Yao, Qinghua Cui, Yingping Liu, Jichun Yang, Shouling Wu, Xingquan Zhao, Yong Zhou
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adults aged ≥40 years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS)...
February 9, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29417750/does-gradual-change-in-head-positioning-affect-cerebrovascular-physiology
#20
Man Y Lam, Victoria J Haunton, Thompson G Robinson, Ronney B Panerai
We studied cerebral blood velocity (CBV), and associated hemodynamic parameters during gradual changes in head positioning in a nonstroke group. CBV (transcranial Doppler ultrasound), beat-to-beat blood pressure (BP, Finometer), and end-tidal carbon dioxide (ETCO2 , capnography) were recorded between lying flat (0°) and sitting up (30°) head positions, in 18 volunteers (10 female, mean age, 57 ± 16 years), at two visits (12 ± 8 days). A significant reduction was found between 5-min FLAT (0°) and 5-min SIT (30°) positions in CBV (visit 1: 4...
February 2018: Physiological Reports
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