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https://www.readbyqxmd.com/read/29044586/males-with-prolactinoma-are-at-increased-risk-of-incident-cardiovascular-disease
#1
Konstantinos A Toulis, Tim Robbins, Narendra Reddy, Balachandran Kumarendran, Krishna Gokhale, Haren Wijesinghe, Kar Keung Cheng, Niki Karavitaki, John Wass, Krishnarajah Nirantharakumar
OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index, and smoking status were used as matching parametres...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29040888/physical-capability-predicts-mortality-in-late-mid-life-as-well-as-in-old-age-findings-from-a-large-british-cohort-study
#2
Victoria L Keevil, Robert Luben, Shabina Hayat, Avan A Sayer, Nicholas J Wareham, Kay-Tee Khaw
INTRODUCTION: Low physical capability predicts mortality, perhaps by association with co-morbidity. However, few studies include participants <70years old with lower co-morbidity burdens compared to older adults. We examined relationships between usual walking speed (UWS), timed chair stands speed, grip strength, standing balance and all-cause mortality in 8477 participants aged 48-92years enrolled in the European Prospective Investigation of Cancer-Norfolk study. METHODS: Participants (55...
October 4, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29040040/prevalence-of-carotid-web-in-patients-with-acute-intracranial-stroke-due-to-intracranial-large-vessel-occlusion
#3
Kars C J Compagne, Ad C G M van Es, Olvert A Berkhemer, Jordi Borst, Yvo B W E M Roos, Robert J van Oostenbrugge, Wim H van Zwam, Charles B L M Majoie, Henk A Marquering, Diederik W J Dippel, Aad van der Lugt, Bart J Emmer
Purpose To investigate the prevalence of symptomatic carotid web in patients with acute ischemic stroke due to intracranial large vessel occlusion, to determine the clinical and imaging profile of patients with carotid web as well as their association with ischemic stroke, and to determine the interobserver agreement in the assessment of carotid webs. Materials and Methods All patients (n = 500) of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) in whom the carotid bifurcation could be assessed (n = 443) were included...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29037206/effects-of-continuous-visual-feedback-during-sitting-balance-training-in-chronic-stroke-survivors
#4
Laura Pellegrino, Psiche Giannoni, Lucio Marinelli, Maura Casadio
BACKGROUND: Postural control deficits are common in stroke survivors and often the rehabilitation programs include balance training based on visual feedback to improve the control of body position or of the voluntary shift of body weight in space. In the present work, a group of chronic stroke survivors, while sitting on a force plate, exercised the ability to control their Center of Pressure with a training based on continuous visual feedback. The goal of this study was to test if and to what extent chronic stroke survivors were able to learn the task and transfer the learned ability to a condition without visual feedback and to directions and displacement amplitudes different from those experienced during training...
October 16, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29036839/stroke-and-sexual-functioning-a-literature-review
#5
Anabelle Grenier-Genest, Marina Gérard, Frédérique Courtois
BACKGROUND: Stroke has multiple impacts on patients' sexual functioning, be it directly caused by the neurological lesion (s) or indirectly triggered via other psychophysiological processes. Despite a growing number of publications, sexuality is still rarely addressed in the stroke literature - yet, patients have indicated their need for sexual rehabilitation services. OBJECTIVE: To provide a literature review on post-stroke sexual functioning as well as available rehabilitation programs targeting patients' sexuality...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29036623/predictors-of-mortality-in-high-risk-patients-with-qt-prolongation-in-a-community-hospital
#6
Charlotte Gibbs, Jacob Thalamus, Kristian Heldal, Øystein Lunde Holla, Kristina H Haugaa, Jan Hysing
Aims: To determine predictors of mortality in patients with corrected QT interval (QTc) ≥ 500 ms in a community hospital. Methods and results: In this retrospective observational study, we searched the electrocardiogram (ECG) database at Telemark Hospital Trust, Norway, from January 2004 to December 2014. Medication, electrolyte abnormalities, and medical conditions known to prolong the QT interval were recorded. From the medical records, we assessed whether the prolonged QTc was noted by the health care providers...
October 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29033504/procedural-characteristics-and-outcomes-of-transcatheter-aortic-valve-implantation-a-single-center-experience-of-the-first-100-inoperable-or-high-surgical-risk-patients-with-severe-aortic-stenosis
#7
Ying-Hwa Chen, Hsiao-Huang Chang, Po-Lin Chen, Zen-Chung Weng, I-Ming Chen, Hsin-Bang Leu, Chun-Yang Huang, Su-Man Lin, Mei-Han Wu
BACKGROUND: This is the first study of a Taiwanese population reporting transcatheter aortic valve implantation (TAVI) outcomes of the first 100 cases from a single center offering two different transcatheter heart valve technologies via six types of approaches. We herein report the 30-day and one-year outcomes in our first 100 TAVI patients at Taipei Veterans General Hospital. METHODS: From May 2010 to April 2016, 100 consecutive patients with severe aortic stenosis (AS) who were considered unsuitable or at high risk for surgical aortic valve replacement underwent TAVI...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29032886/prevalence-and-risk-factors-for-paroxysmal-atrial-fibrillation-and-flutter-detection-after-cryptogenic-ischemic-stroke
#8
Claire Carrazco, Daniel Golyan, Michael Kahen, Karen Black, Richard B Libman, Jeffrey M Katz
INTRODUCTION: Long-term cardiac monitoring with implantable loop recorders (ILRs) has revealed occult paroxysmal atrial fibrillation and flutter (PAF) in a substantial minority of cryptogenic ischemic stroke (CIS) patients. Herein, we aim to define the prevalence, clinical relevance, and risk factors for PAF detection following early poststroke ILR implantation. MATERIALS AND METHODS: A retrospective study of CIS patients (n = 100, mean age 65.8 years; 52.5% female) who underwent ILR insertion during, or soon after, index stroke admission...
October 9, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29030342/the-sex-specific-impact-of-aging-on-the-blood-pressure-response-to-exercise
#9
Joel D Trinity, Gwenael Layec, Corey R Hart, Russell S Richardson
An exaggerated blood pressure (BP) response to exercise has been linked to cardiovascular disease (CVD), but little is known about the impact of age and sex on this response. Therefore, this study examined the hemodynamic and skeletal muscle metabolic response to dynamic plantar flexion exercise, at 40% of WRmax, in 40 physical activity-matched young (n=20, 23±1 yr) and old (n=20, 73±2 yr), equally distributed, male and female subjects. Central hemodynamics and BP (finometer), popliteal artery (PA) blood flow (Doppler ultrasound), and skeletal muscle metabolism (phosphorous magnetic resonance spectroscopy, (31)P-MRS) were measured during 5 mins of plantar flexion exercise...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29029180/cerebral-strokes-in-children-on-intracorporeal-ventricular-assist-devices-analysis-of-the-euromacs-registry
#10
Martin Schweiger, Oliver Miera, Theo M M H de By, Michael Hübler, Felix Berger, Mustafa Özbaran, Antonio Loforte, Burkhardt Seifert, Gaetano Gargiulo, Jan Gummert, Paul Mohacsi
OBJECTIVES: Little is known about cerebral strokes in paediatric patients supported by intracorporeal continuous-flow ventricular assist devices. METHODS: We retrospectively investigated patients younger than 19 years of age who were treated with an intracorporeal continuous-flow ventricular assist device in the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) database. The patients were stratified by body surface area in Group 1 [<1...
September 25, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029108/relative-risks-of-contributing-factors-to-morbidity-and-mortality-in-adults-with-craniopharyngioma-on-gh-replacement
#11
Kevin C J Yuen, Anders F Mattsson, Pia Burman, Eva-Marie Erfurth, Cecilia Camacho-Hubner, Janet L Fox, Johan Verhelst, Mitchell E Geffner, Roger Abs
Context: Craniopharyngioma (CP) in adults, of either childhood-onset (CO-CP) or adult-onset (AO-CP), is associated with increased morbidity and mortality, but data on the relative risks (RRs) of contributing factors are lacking. Objective: To assess the RRs of factors contributing to morbidity and mortality of adults with CO-CP and AO-CP. Methods: Data on 1,669 CP patients from KIMS (Pfizer International Metabolic Database) were analyzed using univariate and multiple Poisson and Cox regression methods...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026379/distribution-of-symptoms-of-post-stroke-depression-in-relation-to-some-characteristics-of-the-vulnerable-patients-in-socio-cultural-context
#12
Sam C Ibeneme, Akachukwu O Nwosu, Georgian C Ibeneme, Muideen O Bakare, Gerhard Fortwengel, Dnyanesh Limaye
OBJECTIVE: To determine the distribution of symptoms of post-stroke depression (PSD) in relation to some predisposing factors in an African population. RELEVANCE: Environment is a key determinant of behavior, and varied socio-cultural contexts must have implications for modifiable characteristics (age, duration of the stroke, marital status, type of employment, gender, the location of cerebral lesion and complications) of individuals vulnerable to PSD, which may be targeted to enhance recovery...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026367/mitochondrial-encephalomyopathy-with-lactic-acidosis-and-stroke-like-episodes-melas-syndrome
#13
Caitlin Henry, Neema Patel, William Shaffer, Lillian Murphy, Joe Park, Bradley Spieler
BACKGROUND: Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome is a rare inherited disorder that results in waxing and waning nervous system and muscle dysfunction. MELAS syndrome may overlap with other neurologic disorders but shows distinctive imaging features. CASE REPORT: We present the case of a 28-year-old female with atypical stroke-like symptoms, a strong family history of stroke-like symptoms, and a relapsing-remitting course for several years...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29025253/pathology-of-mitochondria-in-melas-syndrome-an-ultrastructural-study
#14
Paulina Felczak, Eliza Lewandowska, Iwona Stępniak, Monika Ołdak, Agnieszka Pollak, Urszula Lechowicz, Elżbieta Pasennik, Tomasz Stępień, Teresa Wierzba-Bobrowicz
Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented. We observed proliferation and/or pleomorphism of mitochondria in skeletal muscle and smooth muscle cells of arterioles, as well as in pericytes of capillaries. Paracrystalline inclusions were found only in damaged mitochondria of skeletal muscle. Genetic testing revealed a point mutation in A3243G tRNALeu(UUR) typical for MELAS syndrome...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025084/association-between-adult-height-myocardial-infarction-heart-failure-stroke-and-death-a-korean-nationwide-population-based-study
#15
Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyun Jung Lee, Tae-Min Rhee, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Si-Hyuck Kang, Seil Oh
Background: The association between adult height and cardiovascular (CV) events and mortality has been suggested, albeit inconsistently. We sought to discover the comprehensive relationship between height, CV-related morbidity and all-cause death according to age. Methods: We investigated the association between adult height and myocardial infarction (MI), heart failure (HF), stroke incidence and mortality in 16 528 128 Korean patients who underwent regular health check-ups (2005-08)...
September 5, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024265/effectiveness-of-a-handmade-new-carotid-catheter-in-transradial-carotid-angiography-a-comparison-with-conventional-multipurpose-catheters
#16
Yakup Balaban
OBJECTIVE: The incidence and severity of carotid atherosclerosis increases in proportion with coronary artery disease and its severity. A special catheter specifically used for transradial carotid angiography has not yet been marketed. In this study, we investigate the feasibility and safety of our carotid catheter, which was made by reshaping currently available catheters. METHODS: Between 2010 and 2017, a total of 921 patients with indications for carotid angiography were identified after angiographic examinations and included in the study...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29024214/regenerative-medicine-stroke-survivor-and-carer-views-and-motivations-towards-a-proposed-stem-cell-clinical-trial-using-placebo-neurosurgery
#17
Nicola A Cunningham, Purva Abhyankar, Julie Cowie, Jayne Galinsky, Karen Methven
BACKGROUND: Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT). This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial (RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability. OBJECTIVE: To explore views and motivations towards a proposed 2-arm stem cell trial and identify factors that may impede and enhance participation...
October 12, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29022745/real-world-adherence-to-oral-anticoagulant-in-non-valvular-atrial-fibrillation-patients-in-china
#18
Xiao Xiang, Yaying Cao, Kexin Sun, Jing Song, Yaohua Tian, Qiongzhou Yin, Juan Juan, Yonghua Hu
BACKGROUND AND OBJECTIVE: Adherence to oral anticoagulants is crucial for the prevention of ischemic stroke in atrial fibrillation patients; however, evidence of oral-anticoagulant adherence from developing countries is still lacking. Our study aimed to evaluate the current situation and predictors of oral-anticoagulant adherence in non-valvular atrial fibrillation (NVAF) patients in China. METHODS: Records of NVAF patients were obtained from a regional claims database...
October 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29021776/sex-differences-in-rt-pa-utilization-at-hospitals-treating-stroke-the-national-inpatient-sample
#19
Amelia K Boehme, Brendan G Carr, Scott Eric Kasner, Karen C Albright, Michael J Kallan, Mitchell S V Elkind, Charles C Branas, Michael T Mullen
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs across the US. METHODS: Data from the National (Nationwide) Inpatient Sample (NIS) 2004-2010 was utilized to assess sex differences in treatment for ischemic stroke in PSCs compared to non-PSCs. RESULTS: There were 304,152 hospitalizations with a primary diagnosis of ischemic stroke between 2004 and 2010 in the analysis: 75,160 (24...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29021333/is-risk-standardized-in-hospital-stroke-mortality-an-adequate-proxy-for-risk-standardized-30-day-stroke-mortality-data-findings-from-get-with-the-guidelines-stroke
#20
Mathew J Reeves, Gregg C Fonarow, Haolin Xu, Roland A Matsouaka, Ying Xian, Jeffrey Saver, Lee Schwamm, Eric E Smith
BACKGROUND: Hospital profiling is typically undertaken using risk-standardized 30-day mortality, but obtaining these data for hospitals can be difficult. We sought to determine whether risk-standardized in-hospital mortality could serve as an adequate proxy for risk-standardized 30-day mortality data for the purposes of identifying outlier hospitals. METHODS AND RESULTS: Acute ischemic stroke cases entered into GWTG (Get With The Guidelines)-Stroke between 2003 and 2013 were linked to fee-for-service Medicare files to obtain 30-day mortality...
October 2017: Circulation. Cardiovascular Quality and Outcomes
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