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https://www.readbyqxmd.com/read/29677060/cerebral-small-vessel-but-not-large-vessel-disease-is-associated-with-impaired-cerebral-autoregulation-during-cardiopulmonary-bypass-a-retrospective-cohort-study
#1
Yohei Nomura, Roland Faegle, Daijiro Hori, Abbas Al-Qamari, Alexander J Nemeth, Rebecca Gottesman, Gayane Yenokyan, Charles Brown, Charles W Hogue
BACKGROUND: Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associated with impaired cerebral autoregulation during CPB. METHODS: A retrospective cohort analysis of data from 346 patients undergoing cardiac surgery with CPB enrolled in an ongoing prospectively randomized clinical trial of autoregulation monitoring were evaluated...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29675069/moyamoya-vasculopathy-in-indian-children-our-experience
#2
Varsha Anant Patil, Shilpa Dattaprasanna Kulkarni, Chandrashekhar E Deopujari, Naresh K Biyani, Anaita H Udwadia-Hegde, Krishnakumar N Shah
Background: Moyamoya vasculopathy is a chronic progressive vaso-occlusive disease affecting the distal intracranial carotid arteries and their proximal branches. It is an important cause of recurrent strokes in children. Surgical revascularization procedures are now considered as the treatment option for moyamoya vasculopathy. The data from Indian children with moyamoya vasculopathy are limited to a very few studies. Study Design: We analyzed the records of children with moyamoya vasculopathy treated at our tertiary care center from 2000 to 2014...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29673328/effect-of-laser-doppler-flowmetry-and-occlusion-time-on-outcome-variability-and-mortality-in-rat-middle-cerebral-artery-occlusion-inconclusive-results
#3
Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson, Jakob O Ström
BACKGROUND: Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeutic options are few. Several factors have been suggested to explain this translational difficulty, particularly concerning methodology and study design. Consistent infarcts and low mortality might be desirable in some, but not all, studies. Here, we aimed to investigate whether the use of laser Doppler flowmetry (LDF) and the occlusion time (60 vs...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29671868/secondary-prevention-and-lifestyle-indices-after-stroke-in-a-long-term-perspective
#4
A C Jönsson, H Delavaran, H Lövkvist, M Baturova, S Iwarsson, A Ståhl, B Norrving, A Lindgren
OBJECTIVES: To describe the long-term perspective regarding prevalence of risk factors, secondary stroke prevention, and lifestyle indices after stroke. METHODS: From a population-based one-year cohort (n = 416), we performed an observational study of 145 survivors at 16 months and 10 years after stroke (age 27-97 years) regarding secondary prevention including reaching acceptable treatment goals; nutritional status with focus on underweight; and the lifestyle indices: living situation, level of dependence, and self-assessed health condition...
April 19, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29670827/vasculitis-and-neurobrucellosis-evaluation-of-nine-cases-using-radiologic-findings
#5
Sule Aydin Turkoglu, Siddika Halicioglu, Fatma Sirmatel, Murside Yildiz, Nebil Yildiz, Serpil Yildiz
Background: Brucellosis is an important multisystemic disease with many different clinical symptoms, and its early diagnosis and treatment are possible. Neurobrucellosis (NB) is a rare but serious finding of brucellosis. Brucella can be seen as meningitis and encephalopathy, and it can cause cranial nerve pathologies, vascular syndromes, myopathy, spinal diseases, and psychiatric disorders. In NB, vascular syndromes secondary to inflammation are rarely seen. Here, we present nine young patients with vascular and nonspecific neuropsychiatric findings who had NB as the etiology of stroke...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29670627/sex-differences-in-adipose-tissue-cd8-t-cells-and-regulatory-t-cells-in-middle-aged-mice
#6
Hilda Ahnstedt, Meaghan Roy-O'Reilly, Monica S Spychala, Alexis S Mobley, Javiera Bravo-Alegria, Anjali Chauhan, Jaroslaw Aronowski, Sean P Marrelli, Louise D McCullough
The prevalence of cardiovascular disease has increased among middle-aged women in the United States, yet has declined in middle-aged men. In experimental stroke, middle-aged females have larger strokes and greater inflammation than age-matched males or younger females. The mechanism underlying this shift from an "ischemia-protected" to an "ischemia-sensitive" phenotype in aging females is unknown. One potential factor is an age-related increase in systemic factors that induce inflammation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669946/pravastatin-therapy-during-preeclampsia-prevents-long-term-adverse-health-effects-in-mice
#7
Nicola Garrett, Joaquim Pombo, Michelle Umpierrez, James E Clark, Mark Simmons, Guillermina Girardi
Preeclampsia (PE), associates with long-term increased risk for cardiovascular disease in women, suggesting that PE is not an isolated disease of pregnancy. It is not known if increased risk for long-term diseases is due to PE-specific factors or to prepregnancy renal and cardiovascular risk factors. We used a mouse model in which a WT female with normal prepregnancy health develops PE to investigate if preeclampsia causes long-term cardiovascular consequences after pregnancy for mothers and offspring. Mothers exhibited endothelial dysfunction and hypertension after PE and had glomerular injury that not only persisted but deteriorated, leading to fibrosis...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669439/predictive-value-of-oxidized-low-density-lipoprotein-%C3%AE-2-glycoprotein-i-complexes-oxldl-%C3%AE-2-gpi-in-nonautoimmune-atherothrombosis
#8
Paul R J Ames, Giuseppe Di Girolamo, Giovanna D'Andrea, Luis R Lopez, Giovanni Gaeta, Luigi Iannaccone, Maurizio Maraglione
INTRODUCTION: Lipid oxidation is a definite feature of atherosclerosis, and oxidized low-density lipoprotein (oxLDL) is not only highly immunogenic but toxic to several cell types. Beta-2-glycoprotein-I (β2 GPI) dampens oxLDL toxicity by forming binary oxLDL/β2 GPI complexes. We evaluated whether circulating oxLDL/β2 GPI complexes are associated to atherosclerosis-related events (ARE) and to venous thromboembolism (VTE). METHODS: In a cross-sectional case-control study, cases were (a) 57 consecutive patients (male/female [M/F] 33/24, mean age 57 [10] years) attending a thrombosis unit for ARE (myocardial infarction [MI] n = 20, peripheral vascular disease n = 7, and ischemic strokes n = 30); (b) 52 consecutive patients (M/F 22/30, mean age 55 [17] years) attending the same unit for unprovoked (VTE); (c) normal controls comprised 90 participants (M/F 35/55, mean age 41 [15] years); and (d) oxLDL/β2 GPI complexes were measured by immunoassay and resulting levels divided into quartiles...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29668502/transcatheter-aortic-valve-replacement-efficiency-and-safety-improvements-with-progressive-experience-and-improved-technology
#9
Seyed Hossein Aalaei-Andabili, R David Anderson, Anthony A Bavry, Teng C Lee, Siddharth Wayangankar, George J Arnaoutakis, Thomas M Beaver
OBJECTIVE: Transcatheter aortic valve replacement is now commercially available for intermediate-risk, high-risk, or inoperable patients with severe aortic stenosis. In this study, we investigated change in the safety and efficiency of the transcatheter aortic valve replacement procedure at our institution and patient outcomes comparing our first 100, second 100, and last 100 patients. METHODS: From March 2012 to June 2016, 544 patients underwent transcatheter aortic valve replacement at our center...
April 17, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29667152/falls-in-mexican-older-adults-aged-60-years-and-older
#10
Luis M Valderrama-Hinds, Soham Al Snih, Nai-Wei Chen, Martin A Rodriguez, Rebeca Wong
BACKGROUND: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults. OBJECTIVES: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older. METHODS: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#11
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29660950/impact-of-balance-on-functional-independence-after-stroke-a-cross-sectional-study-at-rehabilitation-settings-in-nigeria
#12
Grace Vincent-Onabajo, Emmanuel Joseph, Hadiza Yakubu Musa
BACKGROUND: Functional independence is often compromised after stroke and restoring it is one of the goals of stroke rehabilitation. OBJECTIVE: This study assessed the impact of balance on functional independence after stroke. METHODS: Ninety-five stroke patients undergoing physical rehabilitation at two health institutions in Nigeria participated in the study. Balance and functional independence were respectively assessed with the Berg Balance Scale and the Barthel Index...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29657592/design-and-baseline-characteristics-of-the-xarelto-post-authorization-safety-effectiveness-study-in-japanese-patients-with-atrial-fibrillation-xapass
#13
Satoshi Ogawa, Kazuo Minematsu, Takanori Ikeda, Takanari Kitazono, Jyoji Nakagawara, Susumu Miyamoto, Yuji Murakawa, Yohei Ohashi, Makiko Takeichi, Yutaka Okayama, Satoshi Yamanaka, Lyo Inuyama
Background: The phase III Japanese Rivaroxaban Once-Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (J-ROCKET AF) showed that the rivaroxaban group had a lower event rate of intracranial bleeding than the warfarin group and that rivaroxaban was noninferior to warfarin for the principal safety outcome. However, safety and effectiveness data from unselected patients with AF in everyday clinical practice in Japan are lacking...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29657253/minimally-invasive-mitral-valve-repair-through-right-minithoracotomy-11-year-single-institute-experience
#14
Taichi Sakaguchi, Toshinori Totsugawa, Masahiko Kuinose, Kentaro Tamura, Arudo Hiraoka, Genta Chikazawa, Hidenori Yoshitaka
BACKGROUND: Although minimally invasive mitral valve repair (MIMVR) is increasingly being performed, only a few clinical studies from Japanese institutions have been reported.Methods and Results:From 2006 to 2017, 387 consecutive patients (135 females, mean age 56±13 years) underwent an initial isolated MIMVR through a right minithoracotomy. The mitral etiology was degenerative in 348, functional in 22, and endocarditis in 13 cases. Repair techniques included leaflet resection/plication in 280, chordal reconstruction in 109, and annuloplasty alone in 24 patients, and concomitant procedures included tricuspid valve repair and atrial fibrillation ablation in 70 (18...
April 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29656727/outcomes-in-hospitalized-ischemic-stroke-patients-with-dementia-on-admission-a-population-based-cohort-study
#15
Charlotte Zerna, Mary P Lindsay, Jiming Fang, Richard H Swartz, Eric E Smith
BACKGROUND: Dementia prevalence is rising, and it will double in the next 20 years. This study sought to understand the prevalence of dementia in hospitalized patients with ischemic stroke, and its impact on outcomes. METHODS: Using the Canadian Institute of Health Information's (CIHI) Discharge Abstract Database (DAD), all acute ischemic stroke admissions from April 2003 to March 2015 in Canada (excluding Quebec) were analyzed. Concurrent dementia at the time of admission was assessed based on hospital diagnostic codes...
April 16, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29650382/therapeutic-decisions-in-atrial-fibrillation-for-stroke-prevention-the-role-of-aversion-to-ambiguity-and-physicians-risk-preferences
#16
Luciano A Sposato, Devin Stirling, Gustavo Saposnik
BACKGROUND: Knowledge-to-action gaps influence therapeutic decisions in atrial fibrillation (AF). Physician-related factors are common, but the least studied. We evaluated the prevalence and determinants of physician-related factors and knowledge-to-action gaps among physicians involved in the management of AF patients. DESIGN: In this cross-sectional study, participants from 6 South American countries recruited during an educational program answered questions regarding 16 case scenarios of patients with AF and completed experiments assessing 3 outcome measures: therapeutic inertia, herding, and errors in risk stratification knowledge translated into action (ERSKTA) based on commonly used stratification tools (Congestive heart failure, Hypertension, Age ≥75 years (double), Diabetes mellitus, previous Stroke/transient ischemic attack/thromboembolism (double), Vascular disease, Age 65-74 years, and female gender (score of 0 for males and 1 for female) (CHA2 DS2 -VASc) and Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, and previous Stroke/transient ischemic attack (double) (CHADS2 ))...
April 9, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29650339/a-force-profile-analysis-comparison-between-functional-data-analysis-statistical-parametric-mapping-and-statistical-non-parametric-mapping-in-on-water-single-sculling
#17
REVIEW
John Warmenhoven, Andrew Harrison, Mark A Robinson, Jos Vanrenterghem, Norma Bargary, Richard Smith, Stephen Cobley, Conny Draper, Cyril Donnelly, Todd Pataky
OBJECTIVES: To examine whether the Functional Data Analysis (FDA), Statistical Parametric Mapping (SPM) and Statistical non-Parametric Mapping (SnPM) hypothesis testing techniques differ in their ability to draw inferences in the context of a single, simple experimental design. DESIGN: The sample data used is cross-sectional (two-sample gender comparison) and evaluation of differences between statistical techniques used a combination of descriptive and qualitative assessments...
March 21, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29649701/change-of-heart-dimensions-and-function-during-pregnancy-in-goats
#18
Olga Szaluś-Jordanow, Michał Czopowicz, Lucjan Witkowski, Agata Moroz, Marcin Mickiewicz, Tadeusz Frymus, Iwona Markowska-Daniel, Emilia Bagnicka, Jarosław Kaba
The study aimed to evaluate the effect of pregnancy on heart diameters and function in goats. Transthoracic echocardiography of 12 female dairy goats of two Polish regional breeds was performed. A Mindray M7 diagnostic ultrasound system with Phased Array transducer was used. Simultaneously, electrocardiography was recorded. All animals were examined four times - at mating season, at the end of the first trimester, at the end of the second trimester and just before kidding. Eleven measurements were taken each time: aortic and left atrial diameter (AoD and LAD), right and left ventricular internal diameter in diastole (RVIDd and LVIDd), left ventricular internal diameter in systole (LVIDs), inter-ventricular septum thickness in diastole and systole (IVSd and IVSd) and left ventricular posterior wall in diastole and systole (LVPWd and LVPWs), maximum left and right ventricular outflow tract velocity (RVOT Vmax and LVOT Vmax)...
March 8, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29644897/the-feasibility-acceptability-and-preliminary-efficacy-of-a-low-cost-virtual-reality-based-upper-limb-stroke-rehabilitation-device-a-mixed-methods-study
#19
Alyson Warland, Ioannis Paraskevopoulos, Emmanuel Tsekleves, Jennifer Ryan, Alexander Nowicky, Joanne Griscti, Hannah Levings, Cherry Kilbride
PURPOSE: To establish feasibility, acceptability, and preliminary efficacy of an adapted version of a commercially available, virtual-reality gaming system (the Personalised Stroke Therapy system) for upper-limb rehabilitation with community dwelling stroke-survivors. METHOD: Twelve stroke-survivors (nine females, mean age 58 years, [standard deviation 7.1], median stroke chronicity 42 months [interquartile range 34.7], Motricity index 14-25 for shoulder and elbow) were asked to complete nine, 40-min intervention sessions using two activities on the system over 3 weeks...
April 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29629522/the-influence-of-sex-in-stroke-thrombolysis-a-systematic-review-and-meta-analysis
#20
REVIEW
Mingsu Liu, Guangqin Li, Jie Tang, Yan Liao, Lin Li, Yang Zheng, Tongli Guo, Xin Kang, Maoting Yuan
BACKGROUND AND PURPOSE: There is increasing recognition of the importance of stroke in females to both clinical and public health. The natural course of stroke is worse in females than in males, but the evidence regarding sex disparities in the responses to thrombolysis in stroke patents is still controversial. We compared outcomes after thrombolysis treatment between females and males. METHODS: Clinical trials reported in the Embase, PubMed, and Cochrane Library electronic databases up to March 13, 2017 were included in this analysis...
April 2018: Journal of Clinical Neurology
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