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Karen A Boehme, Juliane Nitsch, Rosa Riester, Rupert Handgretinger, Sabine B Schleicher, Torsten Kluba, Frank Traub
Ewing sarcomas (ES) are rare mesenchymal tumours, most commonly diagnosed in children and adolescents. Arsenic trioxide (ATO) has been shown to efficiently and selectively target leukaemic blasts as well as solid tumour cells. Since multidrug resistance often occurs in recurrent and metastatic ES, we tested potential additive effects of ATO in combination with the cytostatic drugs etoposide and doxorubicin. The Ewing sarcoma cell lines A673, RD-ES and SK-N-MC as well as mesenchymal stem cells (MSC) for control were treated with ATO, etoposide and doxorubicin in single and combined application...
September 21, 2016: International Journal of Oncology
Hindi E Stohl, David A Miller
Careful communication between members of the obstetric team about intrapartum foetal heart rate is critical for clinical management and patient safety. This study evaluated the benefits of two testing modalities in assessing resident physician knowledge of the 2008 NICHD nomenclature. Multiple-choice (MC) and short-answer (SA) examinations were administered to Obstetrics and Gynecology resident physicians before an educational intervention and then immediately after the training, at 6 months and at 12 months...
May 16, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Lixiao Gu, Yuling Chen, Qingtao Wang, Xiaojing Li, Kaixia Mi, Haiteng Deng
Nicotinamide adenine dinucleotide (NAD)-dependent deacetylases (sirtuins) are well conserved from prokaryotes to eukaryotes. Functions and regulations of mammalian sirtuins have been extensively studied and indicate that sirtuins play an important role in regulation of biological processes, whereas functions of mycobacterial sirtuins were less explored. To examine functions of the sirtuin-like protein in mycobacteria, a Mycobacterium smegmatis sirtuin, MSMEG_5175, was overexpressed in a M. smegmatis strain mc(2)155 to generate an MSMEG_5175-overexpression strain (mc(2)155-MS5175) in the present study...
November 6, 2015: Journal of Proteome Research
Paul J Feldblum, Jairus Okech, Rolex Ochieng, Catherine Hart, Grace Kiyuka, Jaim Jou Lai, Valentine Veena
OBJECTIVES: To ascertain clinical sequelae, client satisfaction and sexual behavior 2+ years after male circumcision using the ShangRing device. METHODS: We enrolled 199 men from the Kenya sites (Homa Bay district) participating in a 2012 study of the ShangRing device used in routine male circumcision services (N = 552). We enrolled men who had had the ShangRing placed successfully, and over-sampled men who had had an adverse event and/or were HIV-positive during the field study...
2015: PloS One
Megan M Niedzwiecki, Xinhua Liu, Megan N Hall, Tiffany Thomas, Vesna Slavkovich, Vesna Ilievski, Diane Levy, Shafiul Alam, Abu B Siddique, Faruque Parvez, Joseph H Graziano, Mary V Gamble
BACKGROUND: Depletion of global 5-hydroxymethylcytosine (5-hmC) is observed in human cancers and is strongly implicated in skin cancer development. Although arsenic (As)-a class I human carcinogen linked to skin lesion and cancer risk-is known to be associated with changes in global %5-methylcytosine (%5-mC), its influence on 5-hmC has not been widely studied. METHODS: We evaluated associations of As in drinking water, urine, and blood with global %5-mC and %5-hmC in two studies of Bangladeshi adults: (i) leukocyte DNA in the Nutritional Influences on Arsenic Toxicity study (n = 196; 49% male, 19-66 years); and (ii) peripheral blood mononuclear cell DNA in the Folate and Oxidative Stress study (n = 375; 49% male, 30-63 years)...
November 2015: Cancer Epidemiology, Biomarkers & Prevention
Claus Christian Pieper, Daniel Thomas, Jennifer Nadal, Winfried A Willinek, Hans Heinz Schild, Carsten Meyer
PURPOSE: To intra-individually compare discomfort levels and patient satisfaction after arterial access closure using the ExoSeal(®) vascular closure device (VCD) and manual compression (MC) in a prospective study design. METHODS: Patients undergoing two planned interventions from 07/2013 to 09/2014 could participate in the study. Access closure was performed with an ExoSeal(®)-VCD in one and MC in the other intervention. Patients were clinically and sonographically examined and were given questionnaires 1 day after intervention [groin- and back-pain during bedrest (100-point visual analog scale; 0: no pain); comfortability of bedrest (10-point Likert scale, 1: comfortable), satisfaction with closure (10-point Likert scale, 1: very satisfied)]...
January 2016: Cardiovascular and Interventional Radiology
Peter Kruzliak, Jan Sabo, Anthony Zulli
UNLABELLED: Oxidative stress causes endothelial dysfunction which ultimately leads to atherogenesis, yet anti-oxidant therapy has failed to reduce human clinical outcomes. We hypothesise that endoplasmic reticulum stress and oxidative stress are both present in the endothelial layer of aorta with atherosclerosis. Rabbits were fed for 4 weeks a diet supplemented with 1% methionine +0.5% cholesterol (MC). Control animals received a normal diet. The endothelial function of the abdominal aorta was examined using organ bath techniques...
October 2015: Acta Histochemica
Yang Lu, Jun Wen, DaPeng Chen, LingLing Wu, QingGang Li, Yuansheng Xie, Di Wu, Xiaoluan Liu, XiangMei Chen
BACKGROUND: Mesangial cell (MC) proliferation and apoptosis are the main pathological changes observed in mesangial proliferative nephritis. In this study, we explored the role of cyclins and p53 in modulating MC proliferation and apoptosis in a mouse model of Habu nephritis. METHODS: The Habu nephritis group was prepared by injection of Habu toxin. Mesangiolysis and mesangial expansion were determined by periodic acid-Schiff (PAS) reagent staining. Immunohistochemical analysis of PCNA and KI67, and TUNEL staining were used to detect cell proliferation and apoptosis, respectively...
April 2016: Clinical and Experimental Nephrology
Tanya Ebert, Yuval Zolotov, Shani Eliav, Orit Ginzburg, Irena Shapira, Racheli Magnezi
BACKGROUND: Cannabis has been used throughout history for different purposes but was outlawed in the United States in 1937; many countries followed suit. Although recently reintroduced as a medical treatment in several countries, the use of cannabis in Israel is permitted for some medical purposes but is still controversial, eliciting heated public and professional debate. The few published studies on physicians' attitudes to medical cannabis found them to be generally unsupportive. OBJECTIVES: To examine, for the first time, the experience, knowledge and attitudes of Israeli physicians towards medical cannabis (MC)...
July 2015: Israel Medical Association Journal: IMAJ
Yiyi Yu, Shawn D Burton, Shreejoy J Tripathy, Nathaniel N Urban
Mitral cells (MCs) are a major class of principal neurons in the vertebrate olfactory bulb, conveying odor-evoked activity from the peripheral sensory neurons to olfactory cortex. Previous work has described the development of MC morphology and connectivity during the first few weeks of postnatal development. However, little is known about the postnatal development of MC intrinsic biophysical properties. To understand stimulus encoding in the developing olfactory bulb, we have therefore examined the development of MC intrinsic biophysical properties in acute slices from postnatal day (P)7-P35 mice...
November 2015: Journal of Neurophysiology
B Peter, G E Winter, K Blatt, K L Bennett, G Stefanzl, U Rix, G Eisenwort, E Hadzijusufovic, M Gridling, C Dutreix, G Hoermann, J Schwaab, D Radia, J Roesel, P W Manley, A Reiter, G Superti-Furga, P Valent
Proteomic-based drug testing is an emerging approach to establish the clinical value and anti-neoplastic potential of multikinase inhibitors. The multikinase inhibitor midostaurin (PKC412) is a promising new agent used to treat patients with advanced systemic mastocytosis (SM). We examined the target interaction profiles and the mast cell (MC)-targeting effects of two pharmacologically relevant midostaurin metabolites, CGP52421 and CGP62221. All three compounds, midostaurin and the two metabolites, suppressed IgE-dependent histamine secretion in basophils and MC with reasonable IC(50) values...
February 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
M Florczyk, P Brzuzan, J Krom, M Woźny, A Łakomiak
Recent studies have shown the presence of large amounts of microRNAs (miRNAs; miRs) from damaged cells in the peripheral blood. In this study, we investigated the levels of miRNAs circulating in the blood plasma of whitefish (Coregonus lavaretus) after exposure to microcystin-LR. We used real-time PCR to examine the relative expression of plasma levels of 4 miRNAs (miR-122-5p and let-7c-5p, the liver-enriched microRNAs, miR-148a-3p which promotes the hapatospecific phenotype in mammals, and miR-92a-3p, a cell proliferation and angiogenesis promoter, potentially hepatocarcinogenic) during the first 48 h after exposure to MC-LR...
June 2016: Journal of Fish Diseases
Satoshi Nunomura, Yoshimichi Okayama, Kenji Matsumoto, Noriko Hashimoto, Kaori Endo-Umeda, Tadashi Terui, Makoto Makishima, Chisei Ra
BACKGROUND: The activation of liver X receptor (LXR) α or LXRβ negatively regulates the expression of pro-inflammatory genes in mammalian cells. We recently reported that 25-hydroxycholesterol, a representative LXR-activating oxysterol, suppresses IL-6 production in mouse mast cells (MCs) following its engagement of the high-affinity IgE receptor (FcεRI). This finding suggests that murine MCs express functional LXRs; however, the mechanisms underlying the LXR-dependent repression of the MC-mediated production of pro-inflammatory cytokines, including IL-6, are poorly understood...
September 2015: Allergology International: Official Journal of the Japanese Society of Allergology
Matilde Bianchi, Cynthia K Peterson, Christian W A Pfirrmann, Juerg Hodler, Jennifer Bolton
BACKGROUND: Modic changes (MC) have been linked with low back pain (LBP) and worse outcomes from some treatments. No studies have investigated the impact that MCs may have on patient outcomes from lumbar facet injections. Therefore, the purpose of this study is to investigate whether the presence of Modic changes is related to 'improvement' in patients undergoing imaging-guided lumbar facet injection therapy. METHODS: Outcomes from 226 patients with MRI scans within 3 months of their imaging-guided lumbar facet injections were investigated to determine whether MCs are related to 'improvement' post injection...
2015: BMC Musculoskeletal Disorders
Aya Inaba, Yuko Hamasaki, Kenji Ishikura, Riku Hamada, Tomoyuki Sakai, Hiroshi Hataya, Fumiyo Komaki, Tetsuji Kaneko, Masaaki Mori, Masataka Honda
BACKGROUND: Several recent studies have shown improved short-term outcome of steroid-resistant nephrotic syndrome (SRNS) in children; however, only a few studies have evaluated the long-term outcome. The aims of our study were to obtain detailed data and analyze the long-term outcome of children with SRNS. METHODS: Sixty-nine children with idiopathic SRNS were enrolled and divided into two groups based on initial histopathological patterns: focal segmental glomerulosclerosis (FSGS) and minimal change (MC)/diffuse mesangial proliferation (DMP)...
March 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Rayan S Moussa, Zaklina Kovacevic, Des R Richardson
Chelators such as 2-hydroxy-1-napthylaldehyde isonicotinoyl hydrazone (311) and di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) target tumor cell iron pools and inhibit proliferation. These agents also modulate multiple targets, one of which is the cyclin-dependent kinase inhibitor, p21. Hence, this investigation examined the mechanism of action of these compounds in targeting p21. All the chelators up-regulated p21 mRNA in the five tumor cell-types assessed. In contrast, examining their effect on total p21 protein levels, these agents induced either: (1) down-regulation in MCF-7 cells; (2) up-regulation in SK-MEL-28 and CFPAC-1 cells; or (3) had no effect in LNCaP and SK-N-MC cells...
October 6, 2015: Oncotarget
Zhenzhen Han, Honglin Liu, Juan Meng, Liangbao Yang, Jing Liu, Jinhuai Liu
A portable kit was demonstrated for rapid and reliable surface-enhanced Raman scattering (SERS) detection of drugs in human urine. This kit contains two sealed reagent tubes, a packet of standardized SERS substrates, and a mini Raman device. A 3 min pretreatment for separating amphetamines from human urine was developed with an extraction rate of >80% examined by ultraperformance liquid chromatography (UPLC). Simultaneously, highly reproducible two-dimensional (2D) gold nanorod (GNR) arrays were assembled by the use of methoxymercaptopoly(ethylene glycol) (mPEG-SH) capping...
September 15, 2015: Analytical Chemistry
G Aad, B Abbott, J Abdallah, O Abdinov, R Aben, M Abolins, O S AbouZeid, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, L Adamczyk, D L Adams, J Adelman, S Adomeit, T Adye, A A Affolder, T Agatonovic-Jovin, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, H Akerstedt, T P A Åkesson, G Akimoto, A V Akimov, G L Alberghi, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, G Alimonti, L Alio, J Alison, S P Alkire, B M M Allbrooke, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A Altheimer, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, K Amako, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, A Amorim, S Amoroso, N Amram, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, P Anger, A Angerami, F Anghinolfi, A V Anisenkov, N Anjos, A Annovi, M Antonelli, A Antonov, J Antos, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, A T H Arce, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, O Arnaez, V Arnal, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Asai, N Asbah, A Ashkenazi, B Åsman, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, B Auerbach, K Augsten, M Aurousseau, G Avolio, B Axen, M K Ayoub, G Azuelos, M A Baak, A E Baas, C Bacci, H Bachacou, K Bachas, M Backes, M Backhaus, P Bagiacchi, P Bagnaia, Y Bai, T Bain, J T Baines, O K Baker, P Balek, T Balestri, F Balli, E Banas, Sw Banerjee, A A E Bannoura, H S Bansil, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M Barisonzi, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska, A Baroncelli, G Barone, A J Barr, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, A Basye, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, R Beccherle, P Bechtle, H P Beck, K Becker, M Becker, S Becker, M Beckingham, C Becot, A J Beddall, A Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begel, J K Behr, C Belanger-Champagne, W H Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, O Benary, D Benchekroun, M Bender, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J A Benitez Garcia, D P Benjamin, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, F Berghaus, J Beringer, C Bernard, N R Bernard, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, F Bertolucci, C Bertsche, D Bertsche, M I Besana, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, C Betancourt, S Bethke, A J Bevan, W Bhimji, R M Bianchi, L Bianchini, M Bianco, O Biebel, S P Bieniek, M Biglietti, J Bilbao De Mendizabal, H Bilokon, M Bindi, S Binet, A Bingul, C Bini, C W Black, J E Black, K M Black, D Blackburn, R E Blair, J-B Blanchard, J E Blanco, T Blazek, I Bloch, C Blocker, W Blum, U Blumenschein, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, J A Bogaerts, A G Bogdanchikov, C Bohm, V Boisvert, T Bold, V Boldea, A S Boldyrev, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, S Borroni, J Bortfeldt, V Bortolotto, K Bos, D Boscherini, M Bosman, J Boudreau, J Bouffard, E V Bouhova-Thacker, D Boumediene, C Bourdarios, N Bousson, A Boveia, J Boyd, I R Boyko, I Bozic, J Bracinik, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, H M Braun, S F Brazzale, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, K Bristow, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, J Bronner, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, J Brown, P A Bruckman de Renstrom, D Bruncko, R Bruneliere, A Bruni, G Bruni, M Bruschi, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, S I Buda, I A Budagov, F Buehrer, L Bugge, M K Bugge, O Bulekov, D Bullock, H Burckhart, S Burdin, B Burghgrave, S Burke, I Burmeister, E Busato, D Büscher, V Büscher, P Bussey, J M Butler, A I Butt, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, V M Cairo, O Cakir, P Calafiura, A Calandri, G Calderini, P Calfayan, L P Caloba, D Calvet, S Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, L M Caminada, R Caminal Armadans, S Campana, M Campanelli, A Campoverde, V Canale, A Canepa, M Cano Bret, J Cantero, R Cantrill, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R Caputo, R Cardarelli, T Carli, G Carlino, L Carminati, S Caron, E Carquin, G D Carrillo-Montoya, J R Carter, J Carvalho, D Casadei, M P Casado, M Casolino, E Castaneda-Miranda, A Castelli, V Castillo Gimenez, N F Castro, P Catastini, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, B C Cerio, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, M Cerv, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, I Chalupkova, P Chang, B Chapleau, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, L Chen, S Chen, X Chen, Y Chen, H C Cheng, Y Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, J T Childers, G Chiodini, A S Chisholm, R T Chislett, A Chitan, M V Chizhov, K Choi, S Chouridou, B K B Chow, V Christodoulou, D Chromek-Burckhart, M L Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, G Ciapetti, A K Ciftci, D Cinca, V Cindro, I A Cioara, A Ciocio, Z H Citron, M Ciubancan, A Clark, B L Clark, B L Clark, P J Clark, R N Clarke, W Cleland, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Coffey, J G Cogan, B Cole, S Cole, A P Colijn, J Collot, T Colombo, G Compostella, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S M Consonni, V Consorti, S Constantinescu, C Conta, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, T Cornelissen, M Corradi, F Corriveau, A Corso-Radu, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, D Côté, G Cottin, G Cowan, B E Cox, K Cranmer, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Crispin Ortuzar, M Cristinziani, V Croft, G Crosetti, T Cuhadar Donszelmann, J Cummings, M Curatolo, C Cuthbert, H Czirr, P Czodrowski, S D'Auria, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, A Dafinca, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, N P Dang, A C Daniells, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, W Davey, C David, T Davidek, E Davies, M Davies, P Davison, Y Davygora, E Dawe, I Dawson, R K Daya-Ishmukhametova, K De, R de Asmundis, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, L De Nooij, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, W J Dearnaley, R Debbe, C Debenedetti, D V Dedovich, I Deigaard, J Del Peso, T Del Prete, D Delgove, F Deliot, C M Delitzsch, M Deliyergiyev, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, C Deluca, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, P O Deviveiros, A Dewhurst, S Dhaliwal, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, B Di Girolamo, A Di Mattia, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, E B Diehl, J Dietrich, S Diglio, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, D Dobos, M Dobre, C Doglioni, T Dohmae, J Dolejsi, Z Dolezal, B A Dolgoshein, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, E Dubreuil, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, L Duflot, L Duguid, M Dührssen, M Dunford, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, M Dyndal, C Eckardt, K M Ecker, R C Edgar, W Edson, N C Edwards, W Ehrenfeld, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, M Endo, J Erdmann, A Ereditato, G Ernis, J Ernst, M Ernst, S Errede, E Ertel, M Escalier, H Esch, C Escobar, B Esposito, A I Etienvre, E Etzion, H Evans, A Ezhilov, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, L Fayard, P Federic, O L Fedin, W Fedorko, S Feigl, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, P Fernandez Martinez, S Fernandez Perez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, M Fiascaris, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, A Fischer, C Fischer, J Fischer, W C Fisher, E A Fitzgerald, M Flechl, I Fleck, P Fleischmann, S Fleischmann, G T Fletcher, G Fletcher, T Flick, A Floderus, L R Flores Castillo, M J Flowerdew, A Formica, A Forti, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, D Francis, L Franconi, M Franklin, M Fraternali, D Freeborn, S T French, F Friedrich, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, B G Fulsom, J Fuster, C Gabaldon, O Gabizon, A Gabrielli, A Gabrielli, S Gadatsch, S Gadomski, G Gagliardi, P Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, K K Gan, J Gao, Y Gao, Y S Gao, F M Garay Walls, F Garberson, C García, J E García Navarro, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, C Gatti, A Gaudiello, G Gaudio, B Gaur, L Gauthier, P Gauzzi, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, P Ge, Z Gecse, C N P Gee, D A A Geerts, Ch Geich-Gimbel, M P Geisler, C Gemme, M H Genest, S Gentile, M George, S George, D Gerbaudo, A Gershon, H Ghazlane, B Giacobbe, S Giagu, V Giangiobbe, P Giannetti, B Gibbard, S M Gibson, M Gilchriese, T P S Gillam, D Gillberg, G Gilles, D M Gingrich, N Giokaris, M P Giordani, F M Giorgi, F M Giorgi, P F Giraud, P Giromini, D Giugni, C Giuliani, M Giulini, B K Gjelsten, S Gkaitatzis, I Gkialas, E L Gkougkousis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, G L Glonti, M Goblirsch-Kolb, J R Goddard, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, J Goncalves Pinto Firmino Da Costa, L Gonella, S González de la Hoz, G Gonzalez Parra, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, I Gorelov, B Gorini, E Gorini, A Gorišek, E Gornicki, A T Goshaw, C Gössling, M I Gostkin, D Goujdami, A G Goussiou, N Govender, H M X Grabas, L Graber, I Grabowska-Bold, P Grafström, K-J Grahn, J Gramling, E Gramstad, S Grancagnolo, V Grassi, V Gratchev, H M Gray, E Graziani, Z D Greenwood, K Gregersen, I M Gregor, P Grenier, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, J P Grohs, A Grohsjean, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, L Guan, J Guenther, F Guescini, D Guest, O Gueta, E Guido, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, S Gupta, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, P Haefner, S Hageböck, Z Hajduk, H Hakobyan, M Haleem, J Haley, D Hall, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, M Hamer, A Hamilton, S Hamilton, G N Hamity, P G Hamnett, L Han, K Hanagaki, K Hanawa, M Hance, P Hanke, R Hanna, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, F Hariri, S Harkusha, R D Harrington, P F Harrison, F Hartjes, M Hasegawa, S Hasegawa, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, M Havranek, C M Hawkes, R J Hawkings, A D Hawkins, 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P Teixeira-Dias, K K Temming, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, J Therhaag, T Theveneaux-Pelzer, J P Thomas, J Thomas-Wilsker, E N Thompson, P D Thompson, R J Thompson, A S Thompson, L A Thomsen, E Thomson, M Thomson, R P Thun, M J Tibbetts, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, E Tiouchichine, P Tipton, S Tisserant, T Todorov, S Todorova-Nova, J Tojo, S Tokár, K Tokushuku, K Tollefson, E Tolley, L Tomlinson, M Tomoto, L Tompkins, K Toms, E Torrence, H Torres, E Torró Pastor, J Toth, F Touchard, D R Tovey, T Trefzger, L Tremblet, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, C Troncon, M Trottier-McDonald, M Trovatelli, P True, L Truong, M Trzebinski, A Trzupek, C Tsarouchas, J C-L Tseng, P V Tsiareshka, D Tsionou, G Tsipolitis, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, A Tudorache, V Tudorache, A N Tuna, S A Tupputi, S Turchikhin, D Turecek, R Turra, A J Turvey, P M Tuts, A Tykhonov, M Tylmad, M Tyndel, I Ueda, R Ueno, M Ughetto, M Ugland, M Uhlenbrock, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, C Unverdorben, J Urban, P Urquijo, P Urrejola, G Usai, A Usanova, L Vacavant, V Vacek, B Vachon, C Valderanis, N Valencic, S Valentinetti, A Valero, L Valery, S Valkar, E Valladolid Gallego, S Vallecorsa, J A Valls Ferrer, W Van Den Wollenberg, P C Van Der Deijl, R van der Geer, H van der Graaf, R Van Der Leeuw, N van Eldik, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, R Vanguri, A Vaniachine, F Vannucci, G Vardanyan, R Vari, E W Varnes, T Varol, D Varouchas, A Vartapetian, K E Varvell, F Vazeille, T Vazquez Schroeder, J Veatch, F Veloso, T Velz, S Veneziano, A Ventura, D Ventura, M Venturi, N Venturi, A Venturini, V Vercesi, M Verducci, W Verkerke, J C Vermeulen, A Vest, M C Vetterli, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, R Vigne, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, I Vivarelli, F Vives Vaque, S Vlachos, D Vladoiu, M Vlasak, M Vogel, P Vokac, G Volpi, M Volpi, H von der Schmitt, H von Radziewski, E von Toerne, V Vorobel, K Vorobev, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, Z Vykydal, P Wagner, W Wagner, H Wahlberg, S Wahrmund, J Wakabayashi, J Walder, R Walker, W Walkowiak, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, K Wang, R Wang, S M Wang, T Wang, X Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, M Warsinsky, A Washbrook, C Wasicki, P M Watkins, A T Watson, I J Watson, M F Watson, G Watts, S Watts, B M Waugh, S Webb, M S Weber, S W Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, C Weiser, H Weits, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M Werner, P Werner, M Wessels, J Wetter, K Whalen, A M Wharton, A White, M J White, R White, S White, D Whiteson, F J Wickens, W Wiedenmann, M Wielers, P Wienemann, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, A Wilson, J A Wilson, I Wingerter-Seez, F Winklmeier, B T Winter, M Wittgen, J Wittkowski, S J Wollstadt, M W Wolter, H Wolters, B K Wosiek, J Wotschack, M J Woudstra, K W Wozniak, M Wu, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, D Xu, L Xu, B Yabsley, S Yacoob, R Yakabe, M Yamada, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, K Yamauchi, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, L Yao, W-M Yao, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, A L Yen, E Yildirim, K Yorita, R Yoshida, K Yoshihara, C Young, C J S Young, S Youssef, D R Yu, J Yu, J M Yu, J Yu, L Yuan, A Yurkewicz, I Yusuff, B Zabinski, R Zaidan, A M Zaitsev, J Zalieckas, A Zaman, S Zambito, L Zanello, D Zanzi, C Zeitnitz, M Zeman, A Zemla, K Zengel, O Zenin, T Ženiš, D Zerwas, D Zhang, F Zhang, J Zhang, L Zhang, R Zhang, X Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zhong, B Zhou, C Zhou, L Zhou, L Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, M Zur Nedden, G Zurzolo, L Zwalinski
A search for heavy long-lived multi-charged particles is performed using the ATLAS detector at the LHC. Data collected in 2012 at [Formula: see text] TeV from pp collisions corresponding to an integrated luminosity of 20.3 fb[Formula: see text]are examined. Particles producing anomalously high ionisation, consistent with long-lived massive particles with electric charges from [Formula: see text] to [Formula: see text] are searched for. No signal candidate events are observed, and 95 % confidence level cross-section upper limits are interpreted as lower mass limits for a Drell-Yan production model...
2015: European Physical Journal. C, Particles and Fields
Hyung Gyun Kim, Eun Hee Han, Ji Hye Im, Eun Ji Lee, Sun Woo Jin, Hye Gwang Jeong
Caffeic acid phenethyl ester (CAPE), a natural component of propolis, is reported to have anticarcinogenic properties, although its precise chemopreventive mechanism remains unclear. In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. CAPE reduced the formation of the benzo[a]pyrene-DNA adduct. Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. CAPE treatment also decreased 3-MC-inducible xenobiotic-response element (XRE)-linked luciferase, aryl hydrocarbons receptor (AhR) transactivation and nuclear localization...
September 25, 2015: Biochemical and Biophysical Research Communications
Tomomi Nakamura, Taku Tsuburai, Aya Tokinaga, Izumi Nakajima, Reiko Kitayama, Yuichi Imai, Tomoko Nagata, Hiroshi Yoshida, Fumiki Hirahara, Hideya Sakakibara
Estrogen replacement therapy (ERT) is necessary for uterine development and bone mass acquisition in women with Turner syndrome (TS) suffering from ovarian insufficiency. However, adequate ERT regimens have not yet been established. The aim of this study was to evaluate the efficacy of ERT for both uterine development and bone mass acquisition. One hundred TS patients from Yokohama City University Hospital (88 with primary amenorrhea (PA) and 12 patients with spontaneous menstrual cycles (MC)) were enrolled after obtaining consent...
2015: Endocrine Journal
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