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supracervical ganglion

Manabu Murakami, Takayoshi Ohba, Feng Xu, Eisaku Satoh, Ichiro Miyoshi, Takashi Suzuki, Yoichirou Takahashi, Eiki Takahashi, Hiroyuki Watanabe, Kyoichi Ono, Hironobu Sasano, Noriyuki Kasai, Hiroshi Ito, Toshihiko Iijima
N-type voltage-dependent calcium channels (VDCCs) play determining roles in calcium entry at sympathetic nerve terminals and trigger the release of the neurotransmitter norepinephrine. The accessory beta3 subunit of these channels preferentially forms N-type channels with a pore-forming CaV2.2 subunit. To examine its role in sympathetic nerve regulation, we established a beta3-overexpressing transgenic (beta3-Tg) mouse line. In these mice, we analyzed cardiovascular functions such as electrocardiography, blood pressure, echocardiography, and isovolumic contraction of the left ventricle with a Langendorff apparatus...
September 5, 2008: Journal of Biological Chemistry
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