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https://www.readbyqxmd.com/read/29863794/role-of-anaerobes-in-polymicrobial-communities-and-biofilms-complicating-diabetic-foot-ulcers
#1
Steven L Percival, Matthew Malone, Dieter Mayer, Anne-Marie Salisbury, Gregory Schultz
Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue...
June 4, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29858972/adipose-tissue-derived-stromal-cells-for-wound-healing
#2
Parisa Goodarzi, Sepideh Alavi-Moghadam, Masoumeh Sarvari, Akram Tayanloo Beik, Khadijeh Falahzadeh, Hamidreza Aghayan, Moloud Payab, Bagher Larijani, Kambiz Gilany, Fakher Rahim, Hossein Adibi, Babak Arjmand
Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient's general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge...
June 2, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29847329/infections-complicating-cesarean-delivery
#3
Geeta Sood, Cynthia Argani, Khalil G Ghanem, Trish Perl, Jeanne S Sheffield
PURPOSE OF REVIEW: Cesarean sections are common surgical procedures performed in a healthy population and are unique because of a relatively high rate of postoperative infection. There have been many important advances in understanding the pathogenesis of infection and evaluation of interventions to prevent post cesarean section infections in the last few years. Our purpose in this review is to analyze these new data, discuss unanswered questions, and propose changes in standard of care...
May 29, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29806813/management-of-intra-abdominal-vascular-injury-in-trauma-laparotomy-a-south-african-experience
#4
Ross Weale, Victor Kong, Vassil Manchev, Wanda Bekker, George Oosthuizen, Petra Brysiewicz, Grant Laing, John Bruce, Damian Clarke
BACKGROUND: Intra-abdominal vascular injury (IAVI) is uncommon but continues to be associated with high mortality rates despite technological advances in the past decades. In light of these ongoing developments, we reviewed our contemporary experience with IAVI in an attempt to clarify and refine our management strategies and the outcome of these patients. METHODS: We retrospectively reviewed the charts of all patients admitted between January 2011 and December 2014 at a major trauma centre in South Africa who were found to have an IAVI during laparotomy for trauma...
June 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29799653/bringing-research-to-the-bedside-knowledge-translation-in-the-mental-health-care-of-burns-patients
#5
Michelle Cleary, Denis C Visentin, Sancia West, Sharon Andrews, Loyola McLean, Rachel Kornhaber
Advances in surgical techniques and wound management have improved outcomes for burn patients; however, the psychological impacts on burn survivors have had less attention. There is a higher rate of mental health disorders amongst burns victims, with those with pre-existing mental health conditions likely to have worse outcomes. To implement effective burns care and rehabilitation, knowledge and understanding of mental health issues is required. This position paper discusses the extent to which clinicians currently translate knowledge around mental health and burns into practice to identify enables and inhibitors...
May 25, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29790144/-prone-position-and-nursing-care
#6
Shu-Ju Lu, Shiao-Pei Wang
Acute respiratory distress syndrome (ARDS) is a life-threatening disease, as acute inflammation in the lungs typically leads to hypoxia and symptoms of dyspnea. The treatment modalities of ARDS include mechanical ventilation, corticosteroid, extracorporeal membranous oxygenation, inhaled nitrogen oxide, and the prone position. Among these, the prone position is supported by evidence showing significantly reduced mortality in patients that adopt this modality. Lying in the prone position reduces atelectatic lung volumes by recruitment of dependent parts and facilitates normal regulation of alveolar ventilation, giving better-matched ventilation perfusion and, thus, improved oxygenation...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29787545/recent-advances-in-austere-combat-surgery-use-of-aortic-balloon-occlusion-as-well-as-blood-challenges-by-special-operations-medical-forces-in-recent-combat-operations
#7
D Marc Northern, Justin D Manley, Regan Lyon, Daniel Farber, Benjamin J Mitchell, Kristopher J Filak, Jonathan Lundy, Joe J DuBose, Todd E Rasmussen, John B Holcomb
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) for control of non-compressible torso hemorrhage is a technology that is increasingly being utilized in the combat casualty setting. Its use in the resource restricted environment holds potential to improve hemorrhage control, decrease blood product utilization, decrease morbidity, and improve combat mortality. The objective of this report is to present the single largest series of REBOA use on severely injured combat casualties...
April 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29757494/multifunctional-smart-skin-adhesive-patches-for-advanced-health-care
#8
REVIEW
Insol Hwang, Hong Nam Kim, Minho Seong, Sang-Hyeon Lee, Minsu Kang, Hoon Yi, Won Gyu Bae, Moon Kyu Kwak, Hoon Eui Jeong
A skin adhesive patch is the most fundamental and widely used medical device for diverse health-care purposes. Conventional skin adhesive patches have been mainly utilized for routine medical purposes such as wound management, fixation of medical devices, and simple drug release. In contrast to traditional skin adhesive patches, recently developed patches incorporate multiple key functions of bulky medical devices into a thin, flexible patch based on emerging nanomaterials and flexible electronic technologies...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#9
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29744543/advances-in-processing-chitin-as-a-promising-biomaterial-from-ionic-liquids
#10
Julia L Shamshina, Oleksandra Zavgorodnya, Robin D Rogers
Chitin isolated through microwave-assisted dissolution using ionic liquids is a high molecular weight (MW) polymer that can be manufactured into materials of different architectures (e.g., fibers, films, microspheres, nanostructured materials) to be used as wound care dressings, drug delivery devices, scaffolds, etc. However, because of differences from traditional isolation methods and, thus, differences in polymer length and degree of deacetylation, it could exhibit bio-related properties that differ from those of traditionally 'pulped' chitin...
May 10, 2018: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29740979/otoplasty-techniques-in-children-a-comparative-study-of-outcomes
#11
Puvesh Punj, Hsu Phie Chong, Thomas P Cundy, Michelle Lodge, Roger Woods
BACKGROUND: Numerous otoplasty techniques have been described in the literature to correct prominent ears; however, few have focused on the complication rates. We reviewed our experience aiming to assess peri-operative care requirements and complication rates. METHOD: We conducted a retrospective review of 207 otoplasty procedures performed in 119 patients over a 5-year period (2009-2014) at the Women's and Children's Hospital, Adelaide. Information pertaining to demographic details, length of stay, otoplasty technique and complications (early and late) were obtained...
May 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29733454/severe-pain-during-wound-care-procedures-a-cross-sectional-study-protocol
#12
Catherine A Fiala, Linda I Abbott, Cheryl D Carter, Stephen L Hillis, Jessica S Wolf, Meghan Schuster, Rachel Dulski, Elizabeth A Grice, Barbara A Rakel, Sue E Gardner
AIM: The aim of this study is to: 1) develop and evaluate a model to predict severe pain during wound care procedures so that high-risk patients can be targeted for specialised dressings and preventive pain control; and 2) identify biological factors associated with severe pain during wound care procedures so that novel pain control strategies can be developed. BACKGROUND: Wound care procedures such as dressing changes can cause moderate to severe pain in 74% of patients, with nearly half (36%) of all patients experiencing severe pain (rated as 8-10 on a 10-point numeric rating scale) during dressing change...
May 7, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29733066/de-las-primeras-iniciativas-de-medicina-laboral-en-m%C3%A3-xico-el-hospital-de-mineros-de-real-del-monte
#13
José Luis Gómez, Carlos Agustín Rodríguez-Paz
A pesar de la legislación de Otto von Bismarck (1815-1898) sobre derechos de seguridad social formulada en 1883 en Alemania donde se señala que es deber del Estado promover el bienestar de todos los miembros de la sociedad, particularmente de los más débiles y necesitados utilizando los medios con los que dispone, y las propuestas de leyes contra accidentes expedidas el 30 de abril de 1904 en el Estado de México, en el México del porfiriato no se consideró brindar atención médica formal a los trabajadores, salvo algunas empresas ferrocarrileras, no se construyeron hospitales para atender a pacientes con enfermedades laborales...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29685635/physiology-not-modern-operative-approach-predicts-mortality-in-extremity-necrotizing-soft-tissue-infections-at-a-high-volume-center
#14
Margaret H Lauerman, Thomas M Scalea, W Andrew Eglseder, Raymond Pensy, Deborah M Stein, Sharon Henry
BACKGROUND: Multiple factors are associated with mortality in necrotizing soft tissue infection, such as organ dysfunction and underlying medical comorbidities, but are not often modifiable. Operative interventions are an attractive modifiable variable in modern management of extremity necrotizing soft tissue infection, but the influence of amputation and advanced wound management techniques on mortality is unknown. METHODS: A single-institution review was performed of extremity necrotizing soft tissue infection ...
April 20, 2018: Surgery
https://www.readbyqxmd.com/read/29683538/effectiveness-of-viable-cryopreserved-placental-membranes-for-management-of-diabetic-foot-ulcers-in-a-real-world-setting
#15
Katherine M Raspovic, Dane K Wukich, Daniel Q Naiman, Lawrence A Lavery, Robert S Kirsner, Paul J Kim, John S Steinberg, Christopher E Attinger, Alla Danilkovitch
In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% versus 21% (p < 0.01). However, patients in RCTs are not representative of daily physician practice. Healthcare databases serve as a valuable tool to evaluate therapy effectiveness and to supplement evidence from RCTs. The objective of this study was to evaluate the effectiveness of vCPM for DFU management using Net Health's WoundExpert® electronic health records (EHR)...
April 23, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29673841/electrospun-silk-fibroin-fibers-for-storage-and-controlled-release-of-human-platelet-lysate
#16
Cataldo Pignatelli, Giovanni Perotto, Marta Nardini, Ranieri Cancedda, Maddalena Mastrogiacomo, Athanassia Athanassiou
Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited in this field. A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality. Another limiting factor for its extensive use is the difficulty of handling the hPL gels. In this work, silk fibroin-based patches were developed to address several points: improving the handling of hPL, enabling their delivery in a controlled manner and facilitating their storage by creating a device ready to use with expanded shelf life...
June 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29660181/descriptive-vs-mechanistic-scientific-approach-to-study-wound-healing-and-its-inhibition-is-there-a-value-of-translational-research-involving-human-subjects
#17
REVIEW
Irena Pastar, Lulu L Wong, Andjela N Egger, Marjana Tomic-Canic
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound-healing disorders complex and multifactorial, but the corresponding patient population is diverse, often elderly and burdened by multiple comorbidities such as diabetes and cardiovascular disease. The care of such patients requires a dedicated, multidisciplinary team of physicians, surgeons, nurses and scientists. In spite of the critical clinical need, it has been over 15 years since a treatment received approval for efficacy by the FDA in the United States...
May 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29652610/combination-therapy-comprising-a-static-magnetic-field-with-contractility-improves-skin-wounds
#18
Byeong-Wook Song, Hyunki Hong, Yu Jin Jung, Ju Hyung Lee, Bong Soo Kim, Hoon-Bum Lee
Cutaneous wounds can present significant clinical problems because of abnormal healing after deep dermal damage. Despite technical advances in wound care, there are still unmet needs that result from inefficient treatment. In this study, we aimed to improve skin wound healing using a contractibility band with static magnetic field (SMF), termed a magnetic band (Mb). To examine the effect of the Mb on wound healing, full-thickness 15 × 35 mm excision wounds were surgically created on the dorsum of rats...
June 7, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29644145/publicly-reported-wound-healing-rates-the-fantasy-and-the-reality
#19
REVIEW
Caroline E Fife, Kristen A Eckert, Marissa J Carter
Significance: We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Recent Advances: Because no method has existed by which wounds could be stratified according to their likelihood of healing among real-world patients, practitioners have reported fantastically high healing rates. The USWR has developed several risk-stratified wound healing quality measures for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) as part of its Qualified Clinical Data Registry (QCDR)...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644144/comparative-effectiveness-of-a-bioengineered-living-cellular-construct-and-cryopreserved-cadaveric-skin-allograft-for-the-treatment-of-venous-leg-ulcers-in-a-real-world-setting
#20
Terry Treadwell, Michael L Sabolinski, Michelle Skornicki, Nathan B Parsons
Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers...
March 1, 2018: Advances in Wound Care
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