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https://www.readbyqxmd.com/read/28316965/surgical-outcomes-of-biologic-fixation-for-subtrochanteric-fracture-using-locking-compression-plates
#1
Jae Hoon Jang, Jae Min Ahn, Hee Jin Lee, Nam Hoon Moon
PURPOSE: This study aimed to evaluate the surgical outcomes of biologic plating using locking compression plate-distal femur (LCP-DF) in patients with subtrochanteric fracture of the femur. MATERIALS AND METHODS: Between January 2010 and December 2013, 28 consecutive patients with subtrochanteric fractures of the femur, treated with biologic fixation using LCP-DF, were enrolled. Preoperative values, including patient age, sex, body mass index, fracture type, type of lung injury, and surgical timing from injury to surgery, were retrospectively evaluated...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28303659/invasive-characterization-of-atherosclerotic-plaque-in-patients-with-peripheral-arterial-disease-using-near-infrared-spectroscopy-intravascular-ultrasound
#2
Amr E Abbas, Sibin K Zacharias, James A Goldstein, Ivan D Hanson, Robert D Safian
OBJECTIVES: We describe the characteristics of atherosclerotic plaque in patients with peripheral arterial disease (PAD) using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) BACKGROUND: Imaging and autopsy studies have described atherosclerotic plaque in different vascular beds, including varying degrees of lipid, fibrosis, and calcification. Recently, NIRS has been validated as an accurate method for detecting lipid-core plaque (LCP) in the coronary circulation. Invasive evaluation of plaque composition using NIRS-IVUS has not been reported in different peripheral arterial circulations...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28302305/absolute-or-relative-stability-in-minimal-invasive-plate-osteosynthesis-of-simple-distal-meta-or-diaphyseal-tibia-fractures
#3
R Wenger, F Oehme, J Winkler, S M Perren, R Babst, F J P Beeres
INTRODUCTION: Minimal invasive plate osteosynthesis in simple distal meta or diaphyseal tibia fractures can be applied using absolute (lag screw and neutralisation plate; LSN) or relative stability (bridge plate; BP). The primary aim of the study was to compare time to radiological union and time to full weight bearing in the two groups (LSN vs. BP). Reduction was performed either percutaneously or by a minimally open approach (mini open). Secondary aim was to analyse the number of complications between both groups...
March 6, 2017: Injury
https://www.readbyqxmd.com/read/28301543/inflammation-biomarkers-in-blood-as-mortality-predictors-in-community-acquired-pneumonia-admitted-patients-importance-of-comparison-with-neutrophil-count-percentage-or-neutrophil-lymphocyte-ratio
#4
Jose Curbelo, Sergio Luquero Bueno, José María Galván-Román, Mara Ortega-Gómez, Olga Rajas, Guillermo Fernández-Jiménez, Lorena Vega-Piris, Francisco Rodríguez-Salvanes, Belén Arnalich, Ana Díaz, Ramón Costa, Hortensia de la Fuente, Ángel Lancho, Carmen Suárez, Julio Ancochea, Javier Aspa
INTRODUCTION: The increase and persistence of inflammation in community-acquired pneumonia (CAP) patients can lead to higher mortality. Biomarkers capable of measuring this inadequate inflammatory response are likely candidates to be related with a bad outcome. We investigated the association between concentrations of several inflammatory markers and mortality of CAP patients. MATERIAL AND METHODS: This was a prospective study of hospitalised CAP patients in a Spanish university hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28299551/comparative-biomechanical-analysis-of-three-implants-used-in-bicondylar-tibial-fractures
#5
Cosmin Ioan Faur, Bogdan Niculescu
BACKGROUND: Currently, the most difficult-to-treat tibial plateau fractures are complex, comminuted fractures, which result from high-energy trauma. The anatomical reconstruction of the articular surface and the preservation of the soft tissue envelope are required for a good functional result. The aim of this study is to perform a biomechanical evaluation of three constructs used in the treatment of bicondylar fractures: the L‑shaped plate, the LCP locking plate, and the hybrid external fixator...
March 15, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28295790/landscape-features-impact-connectivity-between-soil-populations-a-comparative-study-of-gene-flow-in-earthworms
#6
L Dupont, M Torres-Leguizamon, P René-Corail, J Mathieu
Landscape features are known to alter the spatial genetic variation of above ground organisms. Here, we tested the hypothesis that the genetic structure of below ground organisms also responds to landscape structure. Microsatellite markers were used to carry out a landscape genetic study of two endogeic earthworm species, Allolobophora chlorotica (N = 440, 8 microsatellites) and Aporrectodea icterica (N = 519, 7 microsatellites), in an agricultural landscape in the North of France, where landscape features were characterised with high accuracy...
March 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28291011/effect-of-carbon-derivatives-in-sulfonated-poly-etherimide-liquid-crystal-polymer-composite-for-methanol-vapor-sensing
#7
Souvik Bag, Keerti Rathi, Kaushik Pal
A class of highly sensitive chemiresistive sensors are developed for methanol (MeOH) vapor detection in ambient atmosphere by introducing conductive nanofillers like carbon black (CB), multi-wall carbon nanotubes (MWCNTs),and reduced graphene oxide (RGO) into sulfonated poly(etherimide) (PEI)/liquid crystal polymer (LCP) composite (sPEI-LCP). Polar composites are prepared by sulfonation process for instantaneous enhancement in adsorption capability of the sensing films to the target analyte (MeOH). Sensing properties exhibit that polymer composite based fabricated sensors are efficient for detection of different concentration methanol vapor from 300 to 1200 parts-per-million (ppm) at room temperature...
March 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28287002/poor-relation-between-biomechanical-and-clinical-studies-for-the-proximal-femoral-locking-compression-plate
#8
Bjarke Viberg, Katrine M V Rasmussen, Søren Overgaard, Cecilia Rogmark
Background and purpose - The proximal femur locking compression plate (PF-LCP) is a new concept in the treatment of hip fractures. When releasing new implants onto the market, biomechanical studies are conducted to evaluate performance of the implant. We investigated the relation between biomechanical and clinical studies on PF-LCP. Methods - A systematic literature search of relevant biomechanical and clinical studies was conducted in PubMed on December 1, 2015. 7 biomechanical studies and 15 clinical studies were included...
March 13, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28284981/exosomes-from-m1-polarized-macrophages-potentiate-the-cancer-vaccine-by-creating-a-pro-inflammatory-microenvironment-in-the-lymph-node
#9
Lifang Cheng, Yuhua Wang, Leaf Huang
Exosomes are small membrane-bound vesicular particles generated by most cells for intercellular communication and regulation. During biogenesis, specific lipids, RNAs, proteins, and carbohydrates are enriched and packaged into the vesicles so that the exosomal contents reflect not only the source but also the physiological conditions of the parental cells. These exosomes transport materials or signals to the target cells for diverse physiological purposes. Our study focused on the exosomes derived from M1-polarized, proinflammatory macrophages for the possibility of using M1 exosomes as an immunopotentiator for a cancer vaccine...
March 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28277416/incidence-and-risk-factors-of-hardware-related-complications-after-proximal-femoral-osteotomy-in-children-and-adolescents
#10
Myung Ki Chung, Soon-Sun Kwon, Byung Chae Cho, Gye Wang Lee, Jaeyoung Kim, Seung Jun Moon, Jae Woo Lee, Chin Youb Chung, Ki Hyuk Sung, Kyoung Min Lee, Moon Seok Park
Proximal femoral osteotomy has been used in cerebral palsy, Perthes disease, hip dysplasia, idiopathic femoral anteversion, and various hip diseases in children and adolescents. Conventionally, a blade plate (BP) has been used. However, the pediatric locking compression plate (LCP) has recently been applied widely. We compared the hardware-related complications of the BP and the LCP as well as the factors influencing these complications in patients who have undergone a proximal femoral osteotomy in children and adolescents...
March 8, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28274010/radiological-outcomes-of-distal-radius-fractures-managed-with-2-7mm-volar-locking-plate-fixation-a-retrospective-analysis
#11
Prem Kotian, Srikanth Mudiganty, Rajendra Annappa, Jose Austine
INTRODUCTION: Distal radius fractures accounts for around 15% of all fractures diagnosed and treated in the emergency rooms. These fractures usually result secondary to high velocity injury such as a motor vehicle accident or fall on an out stretched hand. In the elderly, it is a common fragility fracture. Volar Locking Compression Plates (LCP) is effective devices for fixation of the distal radius fractures. There is a lacuna with regard to literature on the 2.7 mm volar LCP and the current study retrospectively assesses the postoperative radiological outcomes...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28266664/the-anti-photoaging-effect-of-antioxidant-collagen-peptides-from-silver-carp-hypophthalmichthys-molitrix-skin-is-preferable-to-tea-polyphenols-and-casein-peptides
#12
Ling Zhang, Yayao Zheng, Xiaofeng Cheng, Mengfei Meng, Yongkang Luo, Bo Li
Applying antioxidants to attenuate skin photoaging has received great attention. In this study, antioxidant collagen peptides (ACPs) with different activities were prepared using different proteases, called high (HCP), medium (MCP) and low antioxidant collagen peptides (LCP). The effects of ACPs, tea polyphenols (TP) and casein peptides (CP) on the photoaged skin of mice were evaluated and compared. Ingestion of ACPs significantly alleviated UV-induced abnormal alterations of skin components and antioxidative indicators in both serum and skin (p < 0...
March 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28265579/the-next-frontier-in-communication-and-the-eclippse-study-bridging-the-linguistic-divide-in-secure-messaging
#13
REVIEW
Dean Schillinger, Danielle McNamara, Scott Crossley, Courtney Lyles, Howard H Moffet, Urmimala Sarkar, Nicholas Duran, Jill Allen, Jennifer Liu, Danielle Oryn, Neda Ratanawongsa, Andrew J Karter
Health systems are heavily promoting patient portals. However, limited health literacy (HL) can restrict online communication via secure messaging (SM) because patients' literacy skills must be sufficient to convey and comprehend content while clinicians must encourage and elicit communication from patients and match patients' literacy level. This paper describes the Employing Computational Linguistics to Improve Patient-Provider Secure Email (ECLIPPSE) study, an interdisciplinary effort bringing together scientists in communication, computational linguistics, and health services to employ computational linguistic methods to (1) create a novel Linguistic Complexity Profile (LCP) to characterize communications of patients and clinicians and demonstrate its validity and (2) examine whether providers accommodate communication needs of patients with limited HL by tailoring their SM responses...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28228100/influence-of-hooks-and-a-lag-screw-on-internal-fixation-plates-for-lateral-malleolar-fracture-a-biomechanical-and-ergonomic-study
#14
Rina Sakai, Masataka Uchino, Terumasa Yoneo, Yasuaki Ohtaki, Hiroaki Minehara, Terumasa Matsuura, Tsutomu Gomi, Masanobu Ujihira
BACKGROUND: For internal fixation of AO classification Type B lateral malleolar fracture, insertion of lag screws into the fracture plane and fixation with a one-third tubular plate as a neutralization plate are the standard treatment procedures. The one-third tubular plate is processed to a hook shape and hung on the distal end of the fibula. In this study, to compare the function of the hook and lag screws of a one-third tubular plate and LCP for osteosynthesis of lateral malleolar fracture, mechanical indices of internal fixation were compared among the one-third tubular plates with lag screws with and without the hook and a locking compression plate...
February 23, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28216596/purification-and-partial-structural-characterization-of-a-complement-fixating-polysaccharide-from-rhizomes-of-ligusticum-chuanxiong
#15
Yuan-Feng Zou, Yu-Ping Fu, Xing-Fu Chen, Ingvild Austarheim, Kari Tvete Inngjerdingen, Chao Huang, Lemlem Dugassa Eticha, Xu Song, Lixia Li, Bin Feng, Chang-Liang He, Zhong-Qiong Yin, Berit Smestad Paulsen
Rhizome of Ligusticum chuanxiong is an effective medical plant, which has been extensively applied for centuries in migraine and cardiovascular diseases treatment in China. Polysaccharides from this plant have been shown to have interesting bioactivities, but previous studies have only been performed on the neutral polysaccharides. In this study, LCP-I-I, a pectic polysaccharide fraction, was obtained from the 100 °C water extracts of L. chuangxiong rhizomes and purified by diethylaminethyl (DEAE) sepharose anion exchange chromatography and gel filtration...
February 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208953/open-reduction-and-volar-plate-fixation-of-dorsally-displaced-distal-radius-fractures-a-prospective-study-of-functional-and-radiological-outcomes
#16
Arjun Ballal, Anand Kumar Sadasivan, Anoop Hegde, Ashwin Shetty
INTRODUCTION: The fractures of the distal radius have always posed a unique challenge to the orthopaedic fraternity. The complex ligamentous and bony anatomy offers a wide variety of fractures to be dealt with around this zone. Over the years these injuries have become common especially in the elderly age group as well as the implants and surgical techniques have improved. AIM: To assess the radiological and functional outcome after fixation of intra-articular dorsally displaced distal radius fractures with open reduction and volar Locking Compression Plate fixation (LCP)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28180930/life-course-persistent-and-adolescence-limited-conduct-disorder-in-a-nationally-representative-us-sample-prevalence-predictors-and-outcomes
#17
Ashlee A Moore, Judy L Silberg, Roxann Roberson-Nay, Briana Mezuk
PURPOSE: The course of conduct disorder (CD) is heterogeneous. Moffitt proposed the heuristic of life course persistent (LCP) and adolescence limited (AL) to differentiate etiologically distinct forms of antisocial behavior (AB), each with distinct predictors and consequences, although a few studies have assessed this demarcation within the context of CD. The objective of this study was to apply Moffitt's taxonomy in a nationally representative US sample to investigate the prevalence, predictors, and outcomes of LCP and AL CD...
February 8, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28174772/collagen-peptides-ameliorate-intestinal-epithelial-barrier-dysfunction-in-immunostimulatory-caco-2-cell-monolayers-via-enhancing-tight-junctions
#18
Qianru Chen, Oliver Chen, Isabela M Martins, Hu Hou, Xue Zhao, Jeffrey B Blumberg, Bafang Li
Dysfunction of the intestinal barrier plays a key role in the pathogenesis of inflammatory bowel disease (IBD) and multiple organ failure. The effect of Alaska pollock skin-derived collagen and its 3 tryptic hydrolytic fractions, HCP (6 kDa retentate), MCP (3 kDa retentate) and LCP (3 kDa permeate) on TNF-α induced barrier dysfunction was investigated in Caco-2 cell monolayers. TNF-α induced barrier dysfunction was significantly attenuated by the collagen and its peptide fractions, especially LCP, compared to TNF-α treated controls (P < 0...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28167788/crystal-structure-of-the-adenosine-a2a-receptor-bound-to-an-antagonist-reveals-a-potential-allosteric-pocket
#19
Bingfa Sun, Priti Bachhawat, Matthew Ling-Hon Chu, Martyn Wood, Tom Ceska, Zara A Sands, Joel Mercier, Florence Lebon, Tong Sun Kobilka, Brian K Kobilka
The adenosine A2A receptor (A2AR) has long been implicated in cardiovascular disorders. As more selective A2AR ligands are being identified, its roles in other disorders, such as Parkinson's disease, are starting to emerge, and A2AR antagonists are important drug candidates for nondopaminergic anti-Parkinson treatment. Here we report the crystal structure of A2A receptor bound to compound 1 (Cmpd-1), a novel A2AR/N-methyl d-aspartate receptor subtype 2B (NR2B) dual antagonist and potential anti-Parkinson candidate compound, at 3...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28166208/in-vitro-reconstitution-demonstrates-the-cell-wall-ligase-activity-of-lcp-proteins
#20
Kaitlin Schaefer, Leigh M Matano, Yuan Qiao, Daniel Kahne, Suzanne Walker
Sacculus is a peptidoglycan (PG) matrix that protects bacteria from osmotic lysis. In Gram-positive organisms, the sacculus is densely functionalized with glycopolymers important for survival, but the way in which assembly occurs is not known. In Staphylococcus aureus, three LCP (LytR-CpsA-Psr) family members have been implicated in attaching the major glycopolymer wall teichoic acid (WTA) to PG, but ligase activity has not been demonstrated for these or any other LCP proteins. Using WTA and PG substrates produced chemoenzymatically, we show that all three proteins can transfer WTA precursors to nascent PGs, establishing that LCP proteins are PG-glycopolymer ligases...
April 2017: Nature Chemical Biology
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