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Kenji Tagashira, Kazuaki Z Takahashi, Jun-Ichi Fukuda, Takeshi Aoyagi
Liquid-crystal polymers (LCPs) are well known materials for functional sensor and actuators, because of their high-responsiveness to an electric field. Owing to their complex physical nature, however, the prediction of the functions of LCPs is a challenge. To attack this problem from a molecular point of view, a simulation study is a promising approach. In this work, for future applications of molecular dynamics simulations to problems involving an electric field, we develop an LCP model which consists of coarse-grained mesogenic molecules and smeared charges...
January 6, 2018: Materials
Prakash Rucktooa, Robert K Y Cheng, Elena Segala, Tian Geng, James C Errey, Giles A Brown, Robert M Cooke, Fiona H Marshall, Andrew S Doré
Here we report an efficient method to generate multiple co-structures of the A2A G protein-coupled receptor (GPCR) with small-molecules from a single preparation of a thermostabilised receptor crystallised in Lipidic Cubic Phase (LCP). Receptor crystallisation is achieved following purification using a low affinity "carrier" ligand (theophylline) and crystals are then soaked in solutions containing the desired (higher affinity) compounds. Complete datasets to high resolution can then be collected from single crystals and seven structures are reported here of which three are novel...
January 8, 2018: Scientific Reports
Arun Aneja, T David Luo, Boshen Liu, Molina Domingo, Kerry Danelson, Jason J Halvorson, Eben A Carroll
BACKGROUND: Intra-articular Pilon fractures remain therapeutically challenging due to osteochondral fracturing and comminution, marginal impaction, and insult to the soft tissue envelope. The purpose of this study was to compare the efficacy of anterolateral distal tibial locking plates in capturing main fracture fragments in tibial plafond fractures. METHODS: From May 2011 to Dec 2015, 169 OTA C-type pilon fractures met inclusion and exclusion criteria with computed tomographic (CT) scans performed prior to definitive fixation...
December 16, 2017: Injury
Andrii Ishchenko, Lingling Peng, Egor Zinovev, Alexey Vlasov, Sung Chang Lee, Alexander Kuklin, Alexey Mishin, Valentin Borshchevskiy, Qinghai Zhang, Vadim Cherezov
Lipidic cubic phase (LCP) has been widely recognized as a promising membrane-mimicking matrix for biophysical studies of membrane proteins and their crystallization in a lipidic environment. Application of this material to a wide variety of membrane proteins, however, is hindered due to a limited number of available host lipids, mostly monoacylglycerols (MAGs). Here, we designed, synthesized and characterized a series of chemically stable lipids resistant to hydrolysis, with properties complementary to the widely used MAGs...
June 7, 2017: Crystal Growth & Design
Chen Xia, Zheng Qiao, Chu Feng, Jung-Sik Kim, Baoyuan Wang, Bin Zhu
Semiconducting-ionic conductors have been recently described as excellent electrolyte membranes for low-temperature operation solid oxide fuel cells (LT-SOFCs). In the present work, two new functional materials based on zinc oxide (ZnO)-a legacy material in semiconductors but exceptionally novel to solid state ionics-are developed as membranes in SOFCs for the first time. The proposed ZnO and ZnO-LCP (La/Pr doped CeO₂) electrolytes are respectively sandwiched between two Ni0.8Co0.15Al0.05Li-oxide (NCAL) electrodes to construct fuel cell devices...
December 28, 2017: Materials
Alex A Padron, John R Owen, Jennifer S Wayne, Sevima A Aktay, Roy F Barnes
OBJECTIVE: This biomechanical study compared the torsional strength and stiffness of a locking compression plate with all locking versus nonlocking screws and examined the effect of placing a locking unicortical or nonlocking bicortical screw nearest the fracture gap in a synthetic bone model. RESULTS: Synthetic bone models simulating a diaphyseal fracture without anatomic reduction were tested using four screw configurations: all bicortical locking (ABL), all bicortical nonlocking (ABN), a hybrid construct with a bicortical nonlocking screw nearest the fracture gap (BN), and a unicortical locking screw placed nearest the fracture gap (UL)...
December 27, 2017: BMC Research Notes
Moritz Crönlein, Martin Lucke, Marc Beirer, Dominik Pförringer, Chlodwig Kirchhoff, Peter Biberthaler, Karl F Braun, Sebastian Siebenlist
BACKGROUND: Management of distal humeral fractures remains to be one of the most challenging aspects in trauma surgery. Low profile plating systems with variable angle screw fixation represent a crucial advancement to the established angular stable locking plates with considerable attention in current research. The aim of the prospective randomized trial was to review the preliminary results and patients' outcome following treatment with these newly developed implants and to rule out potential differences in fracture treatment of two different plating systems...
December 28, 2017: BMC Musculoskeletal Disorders
H Iessa, K Christensen, J A Hall, C J Seal
Orange juice (OJ) and malt extract (ME) samples were treated using an electrokinetic (EK) application to investigate the impact of the pH/Lowest conductivity point (LCP) ratio of experimental materials on the water profile direction and the anolyte to catholyte filtrate ratio. After applying the electric field through samples between two electrodes, filtrate was discharged mainly towards the anode in OJ samples (acidic medium, pH/LCP < 1) and towards the cathode in ME samples (alkaline medium, pH/LCP > 1)...
May 1, 2018: Food Chemistry
Jia-Lin Huang, Hongzhuan Chen, Xiao-Ling Gao
In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make it become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers...
December 20, 2017: Journal of Drug Targeting
Yuhua Wang, Lu Zhang, Zhenghong Xu, Lei Miao, Leaf Huang
We reported a preclinical cancer vaccine that simultaneously introduced an mRNA antigen and an immune checkpoint blocking siRNA into the antigen-presenting cells. This was achieved by formulating both nucleic acid-based immunotherapeutics into a lipid-coated calcium phosphate (LCP) nanoparticle (NP) as a carrier to address the delivery challenge. The PEGylated lipid NPs were functionalized with mannose as the targeting ligand to facilitate the preferential uptake by the dendritic cells (DCs) in the lymph nodes after subcutaneous administration...
November 21, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
L Kerstenetzky, J L Descourouez, M R Jorgenson, D C Felix, D A Mandelbrot, R R Redfield, J S Odorico
No abstract text is available yet for this article.
December 1, 2017: Annals of Pharmacotherapy
Syed Ibrahim, Jimmy Joseph Meleppuram
Objective: Analyze the outcomes of proximal femoral locking compression plate (PF-LCP) in these complex fractures. Methods: This study retrospectively analyzed 21 proximal femoral fractures treated with PF-LCP from June 2013 to February 2015. There were 15 females (71%) and six males (29%) with an average age of 61.4 years (range: 34-80 years). The peritrochanteric fractures constituted by intertrochanteric and subtrochanteric fractures were classified by the Boyd and Griffin classification and Seinshemier's classification, respectively...
November 2017: Revista Brasileira de Ortopedia
Ki-Chul Kwon, Munkh-Uchral Erdenebat, Young-Tae Lim, Kyung-Il Joo, Min-Kyu Park, Heewon Park, Jong-Rae Jeong, Hak-Rin Kim, Nam Kim
An integral imaging microscopy (IIM) system with improved depth-of-field (DoF) using a custom-designed bifocal polarization-dependent liquid-crystalline polymer micro lens array (LCP-MLA) is proposed. The implemented MLA has improved electro-optical properties such as a small focal ratio, high fill factor, low driving voltage, and fast switching speed, utilizing a well-aligned reactive mesogen on the imprinted reverse shape of the lens and a polarization switching layer. A bifocal MLA switches its focal length according to the polarization angle and acquires different DoF information of the specimen...
November 27, 2017: Optics Express
Darrick Jolliffe, David P Farrington, Alex R Piquero, Rolf Loeber, Karl G Hill
This paper builds on our previous systematic review of prospective longitudinal studies and examines the early risk factors associated with life-course persistent offending (LCP), adolescence-limited (AL) and late-onset (LO) offending. Out of the 55 prospective longitudinal studies which theoretically could possess the relevant information, only four provided information about risk factors associated with the different offending types. An additional three provided data so that relevant analyses could be conducted...
March 2017: Aggression and Violent Behavior
Chao Wu, Jie Xu, Yanna Hao, Ying Zhao, Yang Qiu, Jie Jiang, Tong Yu, Peng Ji, Ying Liu
In this study, we developed a lipid-coated hollow calcium phosphate (LCP) nanoparticle for the combined application of two chemotherapeutic drugs to human lung cancer A549 cells. Hydrophilic doxorubicin (DOX) was incorporated into the hollow structure of hollow calcium phosphate (HCP), and a lipid bilayer containing hydrophobic paclitaxel (PTX) was subsequently coated on the surface of HCP. The study on combinational effects demonstrated that the combination of DOX and PTX at a mass ratio of 12:1 showed a synergistic effect against A549 cells...
2017: International Journal of Nanomedicine
Amanda E Halliburton, Ty A Ridenour, Bradley A White, Kirby Deater-Deckard
One important subtyping of behavior problems is Moffitt's (1993) "life-course-persistent" (LCP) and "adolescent limited" (AL) categories of antisocial behavior, which she differentiated in terms of high impulsivity, poor academic performance, and aggression. These problems may be exacerbated by the cumulative effects of chronic stress. Copious evidence has documented validity and developmental differences between these subtypes, whereas far fewer data exist regarding their clinical utility, in spite of the Diagnostic and Statistical Manual's nomenclature including corresponding subtypes based on age-of-onset of behavioral symptoms...
September 2017: Journal of Applied Developmental Psychology
Muhammad Kashif Naseer, Ranjit Kumar Sah, Rana Dilawaiz Nadeem, Syed Muhammad Awais, Muhammad Akhtar
The aim of the study was to see the effectiveness of locking compression plate (LCP) in wedge fracture of diaphysis of radius and ulna in adults. This prospective descriptive case series study inducted total 45 patients presenting with wedge fracture (AO Type, 22-B) of radius and/or ulna. The treatment outcome of these patients were monitored for 24 weeks in 8 visits. Presence or absence of radiological union was noted. The functional outcome was evaluated in terms of Disability of Arm, Shoulder and hand (DASH) score and Grace and Eversmann criteria...
November 2017: JPMA. the Journal of the Pakistan Medical Association
Melih Balci, Deniz Cankaya, Altug Tuncel, Burak Yoldas, Ozer Guzel, Cagdas Senel
PURPOSE: This study was aimed to investigate the effects of trochanteric femur fracture treatment methods on erectile functions of the patients and on sexual functions with their female partners. MATERIALS AND METHODS: A total of 43 patients with trochanteric femur fracture who underwent proximal femoral nail (PFN) or proximal femur locking compression plate (PF-LCP) surgery were included in the study. The PFN implant was applied to group 1 ( n = 23) and the PF-LCP implant to group 2 ( n = 20)...
September 2017: Journal of Orthopaedic Surgery
Andre Wajnsztejn, Robinson Esteves Santos Pires, Alexandre Leme Godoy Dos Santos, Pedro Jose Labronici, Helio Jorge Alvachian Fernandes, Mario Ferretti
PURPOSE: The aim of this study was to evaluate the feasibility of performing minimally-invasive plate osteosynthesis (MIPO) in tibial fractures using two posteromedial incisions, and to measure the distance between the plate and neurovascular structures. MATERIALS AND METHODS: We performed nine dissections of specimens that were submitted to tibial MIPO with two posteromedial incisions. One locking compression plate (LCP) of 14 to 16 holes was inserted into the submuscular tunnel in a retrograde manner...
October 2017: Injury
Valentina Grippo, Su Ma, Roland Ludwig, Lo Gorton, Renata Bilewicz
Lipidic cubic phase systems (LCPs) are excellent carriers for immobilized enzymes due to their biocompatibility and well-defined nanoporous structure. Lipidic cubic phases act as a convenient matrix to incorporate enzymes and hold them in the vicinity of electrode surfaces in their fully active forms. Corynascus thermophilus cellobiose dehydrogenase (CtCDH) was trapped in a monoolein cubic phase, which increased not only its stability, but also its catalytic performance with both enhanced mediated and direct electron transfer with electrodes...
October 13, 2017: Bioelectrochemistry
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