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https://www.readbyqxmd.com/read/27922805/near-infrared-spectroscopy-analysis-of-coronary-chronic-total-occlusions
#1
Georgios E Christakopoulos, Judit Karacsonyi, Barbara Anna Danek, Aris Karatasakis, Aya Alame, Pratik Kalsaria, Atif Mohammed, Michele Roesle, Bavana V Rangan, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVE: To examine the presence and localization of lipid-core plaque (LCP) in coronary vessels with chronic total occlusions (CTOs) using near-infrared spectroscopy (NIRS). METHODS: NIRS imaging was performed after guidewire crossing of the occlusion in 15 patients with CTOs. LCP was defined as ≥2 adjacent 2 mm yellow blocks on the block chemogram. We also measured the maximum lipid-core burden index (LCBI) in a 4 mm length of artery (maxLCBI4mm). Large LCP was defined as maxLCBI4mm ≥500...
December 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27910660/low-noise-heterodyne-receiver-for-electron-cyclotron-emission-imaging-and-microwave-imaging-reflectometry
#2
B Tobias, C W Domier, N C Luhmann, C Luo, M Mamidanna, T Phan, A-V Pham, Y Wang
The critical component enabling electron cyclotron emission imaging (ECEI) and microwave imaging reflectometry (MIR) to resolve 2D and 3D electron temperature and density perturbations is the heterodyne imaging array that collects and downconverts radiated emission and/or reflected signals (50-150 GHz) to an intermediate frequency (IF) band (e.g. 0.1-18 GHz) that can be transmitted by a shielded coaxial cable for further filtering and detection. New circuitry has been developed for this task, integrating gallium arsenide (GaAs) monolithic microwave integrated circuits (MMICs) mounted on a liquid crystal polymer (LCP) substrate...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909754/dual-plate-fixation-on-distal-third-diaphyseal-fracture-of-the-humerus
#3
Jun-Ku Lee, Yun-Sung Choi, Young-Suk Sim, Dae-Sung Choi, Soo-Hong Han
INTRODUCTION: Displaced unstable distal third fractures of the humeral diaphysis are treated surgically through open reduction and internal fixation. Conventionally, surgeons prefer using long plates for secure fixation; however, we performed short plate dual plating for robust fixation that required a smaller incision and less dissection through an anterior approach. In this study, we report the results of dual plating of fractures of the humeral shaft, with radiographic evidence and clinical analysis...
December 1, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27898953/impact-of-improving-dietary-amino-acid-balance-for-lactating-sows-on-efficiency-of-dietary-amino-acid-utilization-and-transcript-abundance-of-genes-encoding-lysine-transporters-in-mammary-tissue
#4
L Huber, C F M de Lange, C W Ernst, U Krogh, N L Trottier
Lactating multiparous Yorkshire sows ( = 64) were used in 2 experiments to test the hypothesis that reducing dietary CP intake and improving AA balance through crystalline AA (CAA) supplementation improves apparent dietary AA utilization efficiency for milk production and increases transcript abundance of genes encoding Lys transporter proteins in mammary tissue. In Exp. 1, 40 sows were assigned to 1 of 4 diets: 1) high CP (HCP; 16.0% CP, as-fed basis; analyzed concentration), 2) medium-high CP (MHCP; 15.7% CP), 3) medium-low CP (MLCP; 14...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27889044/leadless-pacemakers
#5
REVIEW
Mikhael F El-Chami, Faisal M Merchant, Angel R Leon
Leadless pacing is an emerging technology with the potential to significantly improve outcomes associated with the need for long-term pacing. Specifically, the major advantage of leadless systems is abolishing the need for transvenous leads and subcutaneous pockets, both of which account for most adverse events associated with traditional pacemakers. Two leadless pacemakers are currently available: the Nanostim (leadless cardiac pacemaker [LCP]) device (St. Jude Medical, Sylmar, California) and the Micra Transcatheter pacing system (Medtronic, Minneapolis, Minnesota)...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27885262/comparison-of-the-effect-on-bone-healing-process-of-different-implants-used-in-minimally-invasive-plate-osteosynthesis-limited-contact-dynamic-compression-plate-versus-locking-compression-plate
#6
Zichao Xue, Haitao Xu, Haoliang Ding, Hui Qin, Zhiquan An
Minimally invasive plate osteosynthesis (MIPO) has been widely accepted because of its satisfactory clinical outcomes. However, the implant construct that works best for MIPO remains controversial. Different plate designs result in different influence mechanisms to blood flow. In this study, we created ulnar fractures in 42 beagle dogs and fixed the fractures using MIPO. The dogs were randomly divided into two groups and were fixed with a limited contact dynamic compression plate (LC-DCP) or a locking compression plate (LCP)...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863995/tumor-targeted-delivery-of-sunitinib-base-enhances-vaccine-therapy-for-advanced-melanoma-by-remodeling-the-tumor-microenvironment
#7
Meirong Huo, Yan Zhao, Andrew Benson Satterlee, Yuhua Wang, Ying Xu, Leaf Huang
Development of an effective treatment against advanced tumors remains a major challenge for cancer immunotherapy. We have previously developed a potent mannose-modified lipid calcium phosphate (LCP) nanoparticle (NP)-based Trp2 vaccine for melanoma therapy, but because this vaccine can induce a potent anti-tumor immune response only during the early stages of melanoma, poor tumor growth inhibition has been observed in more advanced melanoma models, likely due to the development of an immune-suppressive tumor microenvironment (TME)...
November 15, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27859282/total-quality-index-of-agaricus-bisporus-mushrooms-packed-in-modified-atmosphere
#8
Ilija Djekic, Jovana Vunduk, Igor Tomašević, Maja Kozarski, Predrag Petrovic, Miomir Niksic, Predrag Pudja, Anita Klaus
BACKGROUND: The aim of this study was to develop a total quality index and examine the effects of modified atmosphere packaging (MAP) on the quality of Agaricus bisporus mushrooms, stored for 22 days at 4 °C. Mushrooms were packaged under three MAPs: high nitrogen packaging (HNP); low carbon dioxide packaging (LCP); and low oxygen packaging (LOP). Passive MAP with air inside initially was used as the atmosphere treatment (AIR). RESULTS: This research revealed two phases in quality deterioration of A...
November 18, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27851727/high-resolution-crystal-structure-of-the-human-cb1-cannabinoid-receptor
#9
Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang, Daniel M Rosenbaum
The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG), as well as the widely consumed plant (phyto)cannabinoid Δ(9)-tetrahydrocannabinol (THC)(1). The cannabinoid receptors have been the targets of intensive drug discovery efforts owing to the therapeutic potential of modulators for controlling pain(2), epilepsy(3), obesity(4), and other maladies. Although much progress has recently been made in understanding the biophysical properties of GPCRs, investigations of the molecular mechanisms of the cannabinoids and their receptors have lacked high-resolution structural data...
November 16, 2016: Nature
https://www.readbyqxmd.com/read/27835705/dna-methylation-mediated-downregulation-of-defb1-in-prostate-cancer-cells
#10
Jaehyouk Lee, Jun Hyun Han, Ara Jang, Jin Wook Kim, Soon Auck Hong, Soon Chul Myung
Epigenetic aberrations play crucial roles in prostate cancer (PCa) development and progression. The DEFB1 gene, which encodes human ß-defensin-1 (HBD-1), contributes to innate immune responses and functions as a potential tumor suppressor in urological cancers. We investigated whether differential DNA methylation at the low CpG-content promoter (LCP) of DEFB1 was associated with transcriptional regulation of DEFB1 in PCa cells. To identify distinct CpG loci within the DEFB1 LCP related to the epigenetic regulation of DEFB1, we performed an in vitro methylated reporter assay followed by bisulfite sequencing of the DEFB1 promoter fragment...
2016: PloS One
https://www.readbyqxmd.com/read/27812778/retrospective-analysis-of-extra-articular-distal-humerus-shaft-fractures-treated-with-the-use-of-pre-contoured-lateral-column-metaphyseal-lcp-by-triceps-sparing-posterolateral-approach
#11
Yatinder Kharbanda, Yashwant Singh Tanwar, Vishal Srivastava, Vikas Birla, Ashok Rajput, Ramsagar Pandit
Management of extra-articular distal humerus fractures presents a challenge to the treating surgeon due to the complex anatomy of the distal part of the humerus and complicated fracture morphology. Although surgical treatment has shown to provide a more stable reduction and alignment and predictable return to function, it has been associated with complications like iatrogenic radial nerve palsy, infection, non-union and Implant failure. We in the present series retrospectively analysed 20 patients with extra-articular distal humerus shaft fractures surgically treated using the extra-articular distal humeral locking plate approached by the triceps-sparing posterolateral approach...
November 3, 2016: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/27795328/genes-required-for-bacillus-anthracis-secondary-cell-wall-polysaccharide-synthesis
#12
So-Young Oh, J Mark Lunderberg, Alice Chateau, Olaf Schneewind, Dominique Missiakas
: The secondary cell wall polysaccharide (SCWP) is thought to be essential for vegetative growth and S-layer assembly in Bacillus anthracis, however the genetic determinants for assembly of its trisaccharide repeat structure are not known. Here we report that WpaA (BAS0847) and WpaB (BAS5274) share features with membrane proteins involved in the assembly of O-antigen lipopolysaccharide in Gram-negative bacteria and propose that WpaA and WpaB contribute to the assembly of the SCWP in B...
October 24, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27777819/influence-of-plate-size-and-design-upon-healing-of-ulna-shortening-osteotomies
#13
Anna Jungwirth-Weinberger, Paul Borbas, Andreas Schweizer, Ladislav Nagy
Purpose Ulna-shortening osteotomy is one of the most established and most frequent operations in hand surgery. However, bone union is not always achieved and the use of plates implies potential risks and problems. The traditional points of criticism are the duration of bone healing, the incidence of nonunion, and the necessity of hardware removal due to the soft tissue irritation by the plate or the screws. These shortcomings have been addressed by an increasing standardization of the procedure and finally specific instruments and implants...
November 2016: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/27762236/nerve-cuff-electrode-using-embedded-magnets-and-its-application-to-hypoglossal-nerve-stimulation
#14
Jungmin Seo, Jee Hye Wee, Jeong Hoan Park, Pona Park, Jeong-Whun Kim, Sung June Kim
OBJECTIVE: A novel nerve cuff electrode with embedded magnets was fabricated and developed. In this study, a pair of magnets was fully embedded and encapsulated in a liquid crystal polymer (LCP) substrate to utilize magnetic force in order to replace the conventional installing techniques of cuff electrodes. In vitro and in vivo experiments were conducted to evaluate the feasibility of the magnet-embedded nerve cuff electrode (MENCE). Lastly, several issues pertaining to the MENCE such as the cuff-to-nerve diameter ratio, the force of the magnets, and possible concerns were discussed in the discussion section...
December 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27738267/leaf-miner-induced-morphological-physiological-and-molecular-changes-in-mangrove-plant-avicennia-marina-forsk-vierh
#15
Juan Chen, Zhi-Jun Shen, Wei-Zhi Lu, Xiang Liu, Fei-Hua Wu, Gui-Feng Gao, Yi-Ling Liu, Chun-Sheng Wu, Chong-Ling Yan, Hang-Qing Fan, Yi-Hui Zhang, Hai-Lei Zheng
Avicennia marina (Forsk.) Vierh is a widespread mangrove species along the southeast coasts of China. Recently, the outbreak of herbivorous insect, Phyllocnistis citrella Stainton, a leaf miner, have impacted on the growth of A. marina Little is reported about the responses of A. marina to leaf miner infection at the biochemical, physiological and molecular levels. Here, we reported the responses of A. marina to leaf miner infection from the aspects of leaf structure, photosynthesis, and antioxidant system and miner responsive genes expression...
October 13, 2016: Tree Physiology
https://www.readbyqxmd.com/read/27730367/expert-based-versus-habitat-suitability-models-to-develop-resistance-surfaces-in-landscape-genetics
#16
Pietro Milanesi, R Holderegger, R Caniglia, E Fabbri, M Galaverni, E Randi
Landscape genetics aims to investigate functional connectivity among wild populations by evaluating the impact of landscape features on gene flow. Genetic distances among populations or individuals are generally better explained by least-cost path (LCP) distances derived from resistance surfaces than by simple Euclidean distances. Resistance surfaces reflect the cost for an organism to move through particular landscape elements. However, determining the effects of landscape types on movements is challenging...
October 11, 2016: Oecologia
https://www.readbyqxmd.com/read/27729019/enterococcus-hirae-lcpa-psr-a-new-peptidoglycan-binding-protein-localized-at-the-division-site
#17
Maxime Maréchal, Ana Amoroso, Cécile Morlot, Thierry Vernet, Jacques Coyette, Bernard Joris
BACKGROUND: Proteins from the LytR-CpsA-Psr family are found in almost all Gram-positive bacteria. Although LCP proteins have been studied in other pathogens, their functions in enterococci remain uncharacterized. The Psr protein from Enterococcus hirae, here renamed LcpA, previously associated with the regulation of the expression of the low-affinity PBP5 and β-lactam resistance, has been characterized. RESULTS: LcpA protein of E. hirae ATCC 9790 has been produced and purified with and without its transmembrane helix...
October 12, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27726881/successful-strategies-to-determine-high-resolution-structures-of-gpcrs
#18
Jin Xiang, Eugene Chun, Chang Liu, Liang Jing, Zina Al-Sahouri, Lan Zhu, Wei Liu
G protein-coupled receptors (GPCRs) constitute the largest class of drug targets in the human genome, which highlights the importance of understanding the molecular basis of their activation, downstream signaling, and regulation. Since 2007, great progress has been made in the field of GPCR structure determination and their signaling complexes at the molecular level. Here, we summarize the high-resolution structures of over 30 different GPCRs with their co-crystallized ligands, and outline the successful strategies involved, including construct design, expression systems, and lipidic cubic phase (LCP) composition, and the many key technical parameters of the crystallization methods...
October 7, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27720182/plate-fixation-in-periprosthetic-femur-fractures-vancouver-type-b1-trochanteric-hook-plate-or-subtrochanterical-bicortical-locking
#19
Mark Lenz, Karl Stoffel, Heike Kielstein, Keith Mayo, Gunther O Hofmann, Boyko Gueorguiev
INTRODUCTION: Proximal plate fixation in periprosthetic femur fractures can be improved by plate anchorage in the greater trochanter (lateral tension band principle) or bicortical locking screw placement beside the prosthesis stem in an embracement configuration. Both concepts were compared in a biomechanical test using a femoral hook plate (hook) or a locking attachment plate (LAP). METHODS: After bone mineral density (BMD) measurement in the greater trochanter, six pairs of fresh frozen human femora were assigned to two groups and instrumented with cemented hip endoprostheses...
December 2016: Injury
https://www.readbyqxmd.com/read/27709224/the-effect-of-intramedullary-pin-size-and-plate-working-length-on-plate-strain-in-locking-compression-plate-rod-constructs-under-axial-load
#20
Tim Pearson, Mark R Glyde, Robert E Day, Giselle L Hosgood
OBJECTIVE: To investigate the effect of intramedullary pin size and plate working length on plate strain in locking compression plate-rod constructs. METHODS: A synthetic bone model with a 40 mm fracture gap was used. Locking compression plates with monocortical locking screws were tested with no pin (LCP-Mono) and intramedullary pins of 20% (LCPR-20), 30% (LCPR-30) and 40% (LCPR-40) of intramedullary diameter. Two screws per fragment modelled a long (8-hole) and short (4-hole) plate working length...
October 6, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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