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https://www.readbyqxmd.com/read/28809637/-comparison-of-short-therm-results-of-conservative-versus-operative-treatment-of-distal-ulna-fractures-associated-with-distal-radius-fracture-treated-by-plate-osteosynthesis
#1
P Meluzinová, L Kopp, P Dráč, K Edelmann, P Obruba
PURPOSE OF THE STUDY The study aims to evaluate and compare the results of conservative and operative treatment of individual types of distal ulna fractures associated with distal radius fracture treated by plate osteosynthesis and to verify the conclusions of the other authors regarding the recommended therapeutic procedures in these fractures. MATERIAL AND METHODS In the period from 08/2013 to 09/2015, a total of 81 patients participated in the prospective randomised study, with the mean follow-up period of 24 months (6-36)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28802419/recalcitrant-aseptic-atrophic-non-union-of-the-shaft-of-the-humerus-after-failure-of-surgical-treatment-management-by-excision-of-non-union-bone-grafting-and-stabilization-by-lcp-in-different-modes
#2
Sudhir Babhulkar, Sushrut Babhulkar, Aditya Vasudev
Non-union of the humeral shaft is infrequently noticed after surgical fixation. Sixty eight patients whose osteosynthesis of humeral shaft had failed leading to non-union were identified over a duration of 10 years from (January 2006 to December 2015). Clinical and radiographical follow-up was available for 64 patients (4 patients were lost for follow-up), with a mean age of 58 years (range 25-78 years). All patients had aseptic atrophic non-union of either: proximal shaft (n=12), mid shaft (n=38), and lower shaft (n=14)...
August 2017: Injury
https://www.readbyqxmd.com/read/28802417/augmentation-plating-in-management-of-failed-femoral-nailing
#3
Rahul Verma, Pulak Sharma, Sanjiv Gaur
INTRODUCTION: Non-union following interlocking nailing is a troubling complication in treatment of shaft femur fractures. There is no clear consensus on the treatment of this problem. This research was undertaken to study the role of augmentation plating combined with exchange nailing in such cases. PATIENTS AND METHODS: A prospective clinical study was undertaken from January 2010 to December 2015. Patients with aseptic femoral shaft non-union, with or without implant failure following intramedullary nailing were included in the study...
August 2017: Injury
https://www.readbyqxmd.com/read/28794904/qbd-based-approach-for-optimization-of-tenofovir-disoproxil-fumarate-loaded-liquid-crystal-precursor-with-improved-permeability
#4
Sharvil Patil, Chandrashekhar Kadam, Varsha Pokharkar
BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28793905/the-liverpool-care-pathway-a-systematic-review-discarded-in-cancer-patients-but-good-enough-for-dying-nursing-home-patients
#5
Bettina S Husebø, Elisabeth Flo, Knut Engedal
BACKGROUND: The Liverpool Care Pathway (LCP) is an interdisciplinary protocol, aiming to ensure that dying patients receive dignified and individualized treatment and care at the end-of-life. LCP was originally developed in 1997 in the United Kingdom from a model of cancer care successfully established in hospices. It has since been introduced in many countries, including Norway. The method was withdrawn in the UK in 2013. This review investigates whether LCP has been adapted and validated for use in nursing homes and for dying people with dementia...
August 9, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28790538/comparison-of-plate-nail-and-external-fixation-in-the-management-of-diaphyseal-fractures-of-the-humerus
#6
Michele Bisaccia, Luigi Meccariello, Giuseppe Rinonapoli, Giuseppe Rollo, Marco Pellegrino, Andrea Schiavone, Cristina Ibáñez Vicente, Pellegrino Ferrara, Marco Filipponi, Auro Caraffa
INTRODUCTION: Humeral shaft fractures are quite common in orthopedics and represent 1-3% of adult fractures. The surgical treatment is the a better choice in order to obtain a reduction and stable alignment and to prevent the complications. The goal of this study was to compare the three techniques (IMN, LCP and EF) in the treatment of diaphyseal fractures of the humerus in the adult patient. MATERIALS AND METHODS: We examined 79 patients with diaphyseal fractures of the humerus...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28752182/the-challenging-surgical-treatment-of-closed-distal-humerus-fractures-in-elderly-and-octogenarian-patients-radiographic-and-functional-outcomes-with-a-minimum-follow-up-of-24%C3%A2-months
#7
Carlo Biz, Silvano Pierluigi Sperotto, Nicola Maschio, Matteo Borella, Claudio Iacobellis, Pietro Ruggieri
INTRODUCTION: The main purpose of this retrospective, non-randomized, case series study was to evaluate the clinical and radiographic outcomes of distal humerus fractures (DHFs) in a consecutive series of elderly patients operatively treated by two surgeons, and second, to identify proper indications for two elderly age ranges and two fracture pattern groups. MATERIALS AND METHODS: From January 2009 to June 2014, 51 patients (pts) underwent open reduction and internal fixation (ORIF) using the locking compression plate (LCP) distal humerus plate (DHP) system at our institution...
July 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28733658/structural-and-functional-analysis-of-latex-clearing-protein-lcp-provides-insight-into-the-enzymatic-cleavage-of-rubber
#8
Lorena Ilcu, Wolf Röther, Jakob Birke, Anton Brausemann, Oliver Einsle, Dieter Jendrossek
Latex clearing proteins (Lcps) are rubber oxygenases that catalyse the extracellular cleavage of poly (cis-1,4-isoprene) by Gram-positive rubber degrading bacteria. Lcp of Streptomyces sp. K30 (LcpK30) is a b-type cytochrome and acts as an endo-type dioxygenase producing C20 and higher oligo-isoprenoids that differ in the number of isoprene units but have the same terminal functions, CHO-CH2- and -CH2-COCH3. Our analysis of the LcpK30 structure revealed a 3/3 globin fold with additional domains at the N- and C-termini and similarities to globin-coupled sensor proteins...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727200/landscape-genetic-analyses-reveal-fine-scale-effects-of-forest-fragmentation-in-an-insular-tropical-bird
#9
Aurélie Khimoun, William Peterman, Cyril Eraud, Bruno Faivre, Nicolas Navarro, Stéphane Garnier
Within the framework of landscape genetics, resistance surface modelling is particularly relevant to explicitly test competing hypotheses about landscape effects on gene flow. To investigate how fragmentation of tropical forest affects population connectivity in a forest-specialist bird species, we optimized resistance surfaces without a priori specification, using least-cost (LCP) or resistance (IBR) distances. We implemented a two-step procedure in order i) to objectively define the landscape thematic resolution (level of detail in classification scheme to describe landscape variables) and spatial extent (area within the landscape boundaries) and then ii) to test the relative role of several landscape features (elevation, roads, land cover) in genetic differentiation in the Plumbeous Warbler (Setophaga plumbea)...
July 20, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28725176/a-potential-animal-model-of-maladaptive-palatable-food-consumption-followed-by-delayed-discomfort
#10
Lital Moshe, Liza Bekker, Aron Weller
Introduction: Binging is the consumption of larger amounts of food in a briefer period of time than would normally be consumed under similar circumstances. Binging requires palatable food (PF) to trigger abnormal eating, probably reflecting gene × environment interactions. In this study we examined the impact of trait binge eating (BE) and its compulsive nature on the conflict between hedonic eating of PF and anticipation of a delayed aversive effect. We used female rats as an animal model similar to other models of BE...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28711667/identification-of-three-homologous-latex-clearing-protein-lcp-genes-from-the-genome-of-streptomyces-sp-strain-cfmr-7
#11
Jayaram Nanthini, Su Yean Ong, Kumar Sudesh
Rubber materials have greatly contributed to human civilization. However, being a polymeric material does not decompose easily, it has caused huge environmental problems. On the other hand, only few bacteria are known to degrade rubber, with studies pertaining them being intensively focusing on the mechanism involved in microbial rubber degradation. The Streptomyces sp. strain CFMR 7, which was previously confirmed to possess rubber-degrading ability, was subjected to whole genome sequencing using the single molecule sequencing technology of the PacBio® RS II system...
July 12, 2017: Gene
https://www.readbyqxmd.com/read/28700902/a-novel-algorithm-to-detect-glaucoma-risk-using-texton-and-local-configuration-pattern-features-extracted-from-fundus-images
#12
U Rajendra Acharya, Shreya Bhat, Joel E W Koh, Sulatha V Bhandary, Hojjat Adeli
Glaucoma is an optic neuropathy defined by characteristic damage to the optic nerve and accompanying visual field deficits. Early diagnosis and treatment are critical to prevent irreversible vision loss and ultimate blindness. Current techniques for computer-aided analysis of the optic nerve and retinal nerve fiber layer (RNFL) are expensive and require keen interpretation by trained specialists. Hence, an automated system is highly desirable for a cost-effective and accurate screening for the diagnosis of glaucoma...
June 29, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28695852/the-multidrug-resistance-transporter-mdfa-from-escherichia-coli-crystallization-and-x-ray-diffraction-analysis
#13
Kumar Nagarathinam, Frank Jaenecke, Yoshiko Nakada-Nakura, Yunhon Hotta, Kehong Liu, So Iwata, Milton T Stubbs, Norimichi Nomura, Mikio Tanabe
The active efflux of antibiotics by multidrug-resistance (MDR) transporters is a major pathway of drug resistance and complicates the clinical treatment of bacterial infections. MdfA is a member of the major facilitator superfamily (MFS) from Escherichia coli and provides resistance to a wide variety of dissimilar toxic compounds, including neutral, cationic and zwitterionic substances. The 12-transmembrane-helix MdfA was expressed as a GFP-octahistidine fusion protein with a TEV protease cleavage site. Following tag removal, MdfA was purified using two chromatographic steps, complexed with a Fab fragment and further purified using size-exclusion chromatography...
July 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28693652/professional-caregivers-experiences-with-the-liverpool-care-pathway-in-dementia-an-ethnographic-study-in-a-dutch-nursing-home
#14
Natashe Lemos Dekker, Marjolein Gysels, Jenny T van der Steen
OBJECTIVE: There are few studies on how professional caregivers apply the Liverpool Care Pathway (LCP) in nursing home care for people with dementia. Further, despite critiques in the United Kingdom, the LCP continues to be used in the Netherlands, while, to the best of our knowledge, no studies have been conducted since its implementation. The purpose of the present study was to analyze professional caregivers' experiences with the LCP in this context. METHOD: This article draws on an ethnographic study...
July 11, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28687645/deficiency-of-rgpg-causes-major-defects-in-cell-division-and-biofilm-formation-and-deficiency-of-lcp-proteins-leads-to-accumulation-of-cell-wall-antigens-in-culture-medium-by-streptococcus-mutans
#15
Arpan De, Sumei Liao, Jacob P Bitoun, Randy Roth, Wandy L Beatty, Hui Wu, Zezhang T Wen
S. mutans is known to possess rhamnose-glucose polysaccharides (RGP), a major cell wall antigen. S. mutans strains deficient of rgpG, encoding the first enzyme of the RGP biosynthesis pathway, were constructed by allelic exchange. The rgpG deficiency had no effect on growth rate, but caused major defects in cell division and altered cell morphology. Unlike the coccoid wild-type, the rgpG mutant existed primarily in chains of swollen, squarish dividing cells. Deficiency of rgpG also causes significant reduction in biofilm formation (P<0...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28677081/the-role-of-impairment-of-mesenchymal-stem-cell-function-in-osteoporotic-bone-fracture-healing
#16
Lihai Zhang, Saeed Miramini, Martin Richardson, Priyan Mendis, Peter Ebeling
With demographic change and increasing life expectancy, osteoporotic fractures have become one of the most prevalent trauma conditions seen in daily clinical practice. A variety of factors are known to affect the rate of healing in osteoporotic conditions (e.g. both biochemical and biomechanical environment of callus cells). However, the influence of impairment of mesenchymal stem cell function in the osteoporotic condition on bone fracture healing has not been fully understood. In the present study, we develop a mathematical model that quantifies the change in biological processes within the fracture callus as a result of osteoporosis...
July 4, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28675310/effect-of-crude-protein-concentration-and-dietary-electrolyte-balance-on-litter-quality-foot-pad-dermatitis-growth-performance-and-processing-yields-in-two-medium-heavy-turkey-hybrids
#17
T Veldkamp, P M Hocking, L J Vinco
1. An experiment was conducted to investigate the effect of crude protein (CP) concentration and dietary electrolyte balance (DEB) on growth performance, processing yields, litter quality and foot pad dermatitis (FPD) in male turkeys from two commercial hybrids. Soya bean meal was replaced by vegetable protein sources selected for lower K concentrations to lower DEB in order to improve litter quality and subsequent quality of foot pads. 2. Effects of CP on litter friability and wetness were not consistent during the production period...
July 4, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28674737/systematic-review-of-the-outcome-of-total-hip-arthroplasty-in-patients-with-sequelae-of-legg-calv%C3%A3-perthes-disease
#18
Sammy A Hanna, Khaled M Sarraf, Manoj Ramachandran, Pramod Achan
BACKGROUND: Total hip arthroplasty (THA) in patients with sequelae of Legg-Calvé-Perthes disease (LCP) is technically demanding because of the disease related deformities occuring in the proximal femur and/or the multiplanar deformities secondary to corrective osteotomies in childhood. Little is known about the long-term outcome of the procedure in this challenging group of patients. METHODS: We carried out a systematic review of the literature to determine the functional outcome, complications and revision rate of THA in patients with sequelae of LCP disease...
August 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28667397/delayed-union-of-humeral-shaft-fractures-comparison-of-autograft-with-and-without-platelet-rich-plasma-treatment-a-randomized-single-blinded-clinical-trial
#19
Carlos Acosta-Olivo, Abiel Garza-Borjon, Mario Simental-Mendia, Felix Vilchez-Cavazos, Yadira Tamez-Mata, Victor Peña-Martinez
INTRODUCTION: Despite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant. MATERIALS AND METHODS: This study was a controlled, randomized, experimental, longitudinal, comparative, prospective, blind clinical trial...
June 30, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28664584/care-professional-s-experiences-about-using-liverpool-care-pathway-in-end-of-life-care-in-residential-care-homes
#20
Sofia Andersson, Olav Lindqvist, Carl-Johan Fürst, Margareta Brännström
BACKGROUND: Residential care homes (RCHs) play an important role in end-of-life care, being the most common place of death for elderly people in several European countries. Care pathways such as the Liverpool Care Pathway for the Dying Patient (LCP) are used to improve and ensure quality care at the end of life. There is a lack of scientific evidence supporting the use of care pathways. DESIGN: A descriptive qualitative study. OBJECTIVE: The aim was to describe care professionals' experiences of using the Liverpool Care Pathway for the Dying Patient in the care of dying residents in residential care homes...
June 29, 2017: Scandinavian Journal of Caring Sciences
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