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https://www.readbyqxmd.com/read/28541152/biomechanical-comparison-of-a-3-5-mm-conical-coupling-plating-system-and-a-3-5-mm-locking-compression-plate-applied-as-plate-rod-constructs-to-an-experimentally-created-fracture-gap-in-femurs-of-canine-cadavers
#1
Giovanni Tremolada, Daniel D Lewis, Ken Luka Paragnani, Bryan P Conrad, Stanley E Kim, Antonio Pozzi
OBJECTIVE To compare stiffness and resistance to cyclic fatigue of two 3.5-mm locking system plate-rod constructs applied to an experimentally created fracture gap in femurs of canine cadavers. SAMPLE 20 femurs from cadavers of 10 mixed-breed adult dogs. PROCEDURES 1 femur from each cadaver was stabilized with a conical coupling plating system-rod construct, and the contralateral femur was stabilized with a locking compression plate (LCP)-rod construct. An intramedullary Steinmann pin was inserted in each femur...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28506180/midterm-follow-up-of-treating-volar-marginal-rim-fractures-with-variable-angle-lcp-volar-rim-distal-radius-plates
#2
Chul Ki Goorens, Stijn Geeurickx, Pascal Wernaers, Barbara Staelens, Thierry Scheerlinck, Jean Goubau
BACKGROUND: Specific treatment of the volar marginal rim fragment of distal radius fractures avoids occurance of volar radiocarpal dislocation. Although several fixation systems are available to capture this fragment, adequately maintaining internal fixation is difficult. We present our experience of the first 10 cases using the 2.4 mm variable angle LCP volar rim distal radius plate (Depuy Synthes®, West Chester, US), a low-profile volar rim-contouring plate designed for distal plate positioning and stable buttressing of the volar marginal fragment...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28500046/roxb-is-a-novel-type-of-rubber-oxygenase-that-combines-properties-of-rubber-oxygenase-roxa-and-latex-clearing-protein-lcp
#3
Jakob Birke, Wolf Röther, Dieter Jendrossek
Only two types of rubber oxygenases, rubber oxygenase (RoxA) and latex clearing protein (Lcp), have been described so far. RoxAs are c-type cytochromes of ≈70 kDa produced by Gram-negative rubber-degrading bacteria and cleave polyisoprene into 12-oxo-4,8-dimethyltrideca-4,8-diene-1-al (ODTD), a C15 oligo-isoprenoid, as major end product. Lcps are common among Gram-positive rubber-degraders and don't share amino acid sequence similarities with RoxA proteins (RoxAs). Furthermore, Lcps have much smaller molecular masses (≈40 kDa), are b-type cytochromes and cleave polyisoprene to a mixture of C20, C25, C30 and higher oligo-isoprenoids as end products...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28489007/-frequency-of-symptoms-and-drug-treatment-among-dying-patients-in-the-last-24-hours-of-life-at-landspitali-the-national-university-hospital-of-iceland-and-in-nursing-homes
#4
Svandis Iris Halfdanardottir, Kristin Lara Olafsdottir, Valgerdur Sigurdardottir
INTRODUCTION: The purpose of this study was to evaluate the frequency of 5 common symptoms and drug treatments prescribed and given in the last 24 hours of life in 11 medical units at Landspitali National University Hospital of Iceland (LUH) and in 7 nursing homes (NH). MATERIAL AND METHODS: Data was collected retrospectively from 232 charts of patients who died in 2012, using documentation in the Liverpool Care Pathway (LCP) and the medication management system...
May 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28453640/pioneering-topological-methods-for-network-based-drug-target-prediction-by-exploiting-a-brain-network-self-organization-theory
#5
Claudio Durán, Simone Daminelli, Josephine M Thomas, V Joachim Haupt, Michael Schroeder, Carlo Vittorio Cannistraci
The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side effects. As experimental testing of DTIs is costly and time-consuming, computational predictors are of great aid. Here, for the first time, state-of-the-art DTI supervised predictors custom-made in network biology were compared-using standard and innovative validation frameworks-with unsupervised pure topological-based models designed for general-purpose link prediction in bipartite networks...
April 26, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28424909/comparison-of-clinical-outcomes-and-quality-of-life-between-laparoscopic-and-open-central-pancreatectomy-with-pancreaticojejunostomy
#6
Ren-Chao Zhang, Bin Zhang, Yi-Ping Mou, Xiao-Wu Xu, Yu-Cheng Zhou, Chao-Jie Huang, Jia-Yu Zhou, Wei-Wei Jin, Chao Lu
BACKGROUND: The studies comparing laparoscopic and open central pancreatectomy with pancreaticojejunostomy are limited. This study aimed to compare clinical outcomes and quality of life of patients undergoing laparoscopic and open central pancreatectomy with pancreaticojejunostomy. METHODS: Between December 1997 and December 2015, patients who underwent central pancreatectomy with pancreaticojejunostomy were reviewed. Patients were divided into 2 groups as laparoscopic central pancreatectomy (LCP) and open central pancreatectomy (OCP)...
April 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28420623/externalised-locking-compression-plate-as-an-alternative-to-the-unilateral-external-fixator-a-biomechanical-comparative-study-of-axial-and-torsional-stiffness
#7
B F H Ang, J Y Chen, A K S Yew, S K Chua, S M Chou, S L Chia, J S B Koh, T S Howe
OBJECTIVES: External fixators are the traditional fixation method of choice for contaminated open fractures. However, patient acceptance is low due to the high profile and therefore physical burden of the constructs. An externalised locking compression plate is a low profile alternative. However, the biomechanical differences have not been assessed. The objective of this study was to evaluate the axial and torsional stiffness of the externalised titanium locking compression plate (ET-LCP), the externalised stainless steel locking compression plate (ESS-LCP) and the unilateral external fixator (UEF)...
April 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28374715/-clinical-experience-with-various-techniques-integrated-treat-the-wounded-with-gunshot-fractures-of-limbs
#8
V K Kozlov, B G Akhmedov, A M Chililov
AIM: To increase an efficiency of complex treatment of patients with diaphyseal gunshot fractures of long bones by introduction of modern minimally invasive surgical techniques of internal osteosynthesis into clinical practice of civil health care and to improve the outcomes in victims. MATERIAL AND METHODS: Prospective comparative clinical trial included 104 victims from the Republic of Yemen with gunshot wounds of limbs of various severity for the period 2009-2011...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28360500/outcome-after-internal-fixation-of-intraarticular-distal-humerus-ao-type-b-c-fractures-preliminary-results-with-anatomical-distal-humerus-lcp-system
#9
Jwalant Patel, Girish Motwani, Himanshu Shah, Rajeev Daveshwar
PURPOSE: The treatment of intraarticular fractures of the distal humerus is challenging and involves the risk of complications and bad functional results. Anatomical and stable internal fixation with early postoperative mobilization is expected to improve the functional outcomes. The objective of this study was to evaluate the functional and radiological results, along with the complications associated, of open reduction and internal fixation using precontoured anatomical locking LCP plate system for intraarticular distal humerus fractures in adult patients...
January 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28356152/mid-term-outcome-following-revision-surgery-of-clavicular-non-and-malunion-using-anatomic-locking-compression-plate-and-iliac-crest-bone-graft
#10
Marc Beirer, Ingo J Banke, Norbert Harrasser, Moritz Crönlein, Dominik Pförringer, Stefan Huber-Wagner, Peter Biberthaler, Chlodwig Kirchhoff
BACKGROUND: Treatment of clavicular non- and malunion is still challenging. Current surgical procedures often result in frustrating functional outcome along with high-grade subjective impairment and increased rates of revision surgery. However, the combination of biological augmentation with vital bone graft and a biomechanically sufficient fixation system seems to be a promising concept of treatment. METHODS: In this retrospective study, 14 patients with a mean age of 44 years (26-67 years) suffering from non-union (n = 11) and/or malunion (n = 3) of the clavicle were enrolled...
March 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28336328/bone-healing-is-achievable-despite-extensive-wound-dehiscence-and-wide-plate-and-screws-exposure-in-children
#11
E Melhem, W Bayoud, I Ghanem
BACKGROUND: Extensive wound dehiscence and wide plate and screw exposure in the early weeks following orthopaedic surgery in children is usually managed either by extensive debridement, lavage and secondary closure or hardware removal and external fixation. PATIENTS: Three children with LCP plate and screws exposure were managed by simple repetitive debridement and local wound care without any IV antibiotics, nor secondary closure or hardware removal. All three cases occurred in the tibia, one following tibial osteotomy in lateral hemimelia with a long history of previous surgeries, one following wide excision of a tibial Ewing sarcoma with chemo- and radiotherapy, and the third following wide excision of a 12cm necrotic tibial segment due to chronic osteomyelitis...
March 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28316965/surgical-outcomes-of-biologic-fixation-for-subtrochanteric-fracture-using-locking-compression-plates
#12
Jae Hoon Jang, Jae Min Ahn, Hee Jin Lee, Nam Hoon Moon
PURPOSE: This study aimed to evaluate the surgical outcomes of biologic plating using locking compression plate-distal femur (LCP-DF) in patients with subtrochanteric fracture of the femur. MATERIALS AND METHODS: Between January 2010 and December 2013, 28 consecutive patients with subtrochanteric fractures of the femur, treated with biologic fixation using LCP-DF, were enrolled. Preoperative values, including patient age, sex, body mass index, fracture type, type of lung injury, and surgical timing from injury to surgery, were retrospectively evaluated...
March 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28303659/invasive-characterization-of-atherosclerotic-plaque-in-patients-with-peripheral-arterial-disease-using-near-infrared-spectroscopy-intravascular-ultrasound
#13
Amr E Abbas, Sibin K Zacharias, James A Goldstein, Ivan D Hanson, Robert D Safian
OBJECTIVES: We describe the characteristics of atherosclerotic plaque in patients with peripheral arterial disease (PAD) using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) BACKGROUND: Imaging and autopsy studies have described atherosclerotic plaque in different vascular beds, including varying degrees of lipid, fibrosis, and calcification. Recently, NIRS has been validated as an accurate method for detecting lipid-core plaque (LCP) in the coronary circulation. Invasive evaluation of plaque composition using NIRS-IVUS has not been reported in different peripheral arterial circulations...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28302305/absolute-or-relative-stability-in-minimal-invasive-plate-osteosynthesis-of-simple-distal-meta-or-diaphyseal-tibia-fractures
#14
R Wenger, F Oehme, J Winkler, S M Perren, R Babst, F J P Beeres
INTRODUCTION: Minimal invasive plate osteosynthesis in simple distal meta or diaphyseal tibia fractures can be applied using absolute (lag screw and neutralisation plate; LSN) or relative stability (bridge plate; BP). The primary aim of the study was to compare time to radiological union and time to full weight bearing in the two groups (LSN vs. BP). Reduction was performed either percutaneously or by a minimally open approach (mini open). Secondary aim was to analyse the number of complications between both groups...
March 6, 2017: Injury
https://www.readbyqxmd.com/read/28301543/inflammation-biomarkers-in-blood-as-mortality-predictors-in-community-acquired-pneumonia-admitted-patients-importance-of-comparison-with-neutrophil-count-percentage-or-neutrophil-lymphocyte-ratio
#15
Jose Curbelo, Sergio Luquero Bueno, José María Galván-Román, Mara Ortega-Gómez, Olga Rajas, Guillermo Fernández-Jiménez, Lorena Vega-Piris, Francisco Rodríguez-Salvanes, Belén Arnalich, Ana Díaz, Ramón Costa, Hortensia de la Fuente, Ángel Lancho, Carmen Suárez, Julio Ancochea, Javier Aspa
INTRODUCTION: The increase and persistence of inflammation in community-acquired pneumonia (CAP) patients can lead to higher mortality. Biomarkers capable of measuring this inadequate inflammatory response are likely candidates to be related with a bad outcome. We investigated the association between concentrations of several inflammatory markers and mortality of CAP patients. MATERIAL AND METHODS: This was a prospective study of hospitalised CAP patients in a Spanish university hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28299551/comparative-biomechanical-analysis-of-three-implants-used-in-bicondylar-tibial-fractures
#16
Cosmin Ioan Faur, Bogdan Niculescu
BACKGROUND: Currently, the most difficult-to-treat tibial plateau fractures are complex, comminuted fractures, which result from high-energy trauma. The anatomical reconstruction of the articular surface and the preservation of the soft tissue envelope are required for a good functional result. The aim of this study is to perform a biomechanical evaluation of three constructs used in the treatment of bicondylar fractures: the L‑shaped plate, the LCP locking plate, and the hybrid external fixator...
March 15, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28295790/landscape-features-impact-connectivity-between-soil-populations-a-comparative-study-of-gene-flow-in-earthworms
#17
L Dupont, M Torres-Leguizamon, P René-Corail, J Mathieu
Landscape features are known to alter the spatial genetic variation of aboveground organisms. Here, we tested the hypothesis that the genetic structure of belowground organisms also responds to landscape structure. Microsatellite markers were used to carry out a landscape genetic study of two endogeic earthworm species, Allolobophora chlorotica (N = 440, eight microsatellites) and Aporrectodea icterica (N = 519, seven microsatellites), in an agricultural landscape in the North of France, where landscape features were characterized with high accuracy...
March 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28291011/effect-of-carbon-derivatives-in-sulfonated-poly-etherimide-liquid-crystal-polymer-composite-for-methanol-vapor-sensing
#18
Souvik Bag, Keerti Rathi, Kaushik Pal
A class of highly sensitive chemiresistive sensors is developed for methanol (MeOH) vapor detection in ambient atmosphere by introducing conductive nanofillers like carbon black, multi-wall carbon nanotubes, and reduced graphene oxide into sulfonated poly(etherimide) (PEI)/liquid crystal polymer (LCP) composite (sPEI-LCP). Polar composites are prepared by a sulfonation process for instantaneous enhancement in adsorption capability of the sensing films to the target analyte (MeOH). Sensing properties exhibit that polymer composite-based fabricated sensors are efficient for the detection of different concentration of methanol vapor from 300-1200 parts-per-million (ppm) at room temperature...
May 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28287002/poor-relation-between-biomechanical-and-clinical-studies-for-the-proximal-femoral-locking-compression-plate
#19
Bjarke Viberg, Katrine M V Rasmussen, Søren Overgaard, Cecilia Rogmark
Background and purpose - The proximal femur locking compression plate (PF-LCP) is a new concept in the treatment of hip fractures. When releasing new implants onto the market, biomechanical studies are conducted to evaluate performance of the implant. We investigated the relation between biomechanical and clinical studies on PF-LCP. Methods - A systematic literature search of relevant biomechanical and clinical studies was conducted in PubMed on December 1, 2015. 7 biomechanical studies and 15 clinical studies were included...
March 13, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28284981/exosomes-from-m1-polarized-macrophages-potentiate-the-cancer-vaccine-by-creating-a-pro-inflammatory-microenvironment-in-the-lymph-node
#20
Lifang Cheng, Yuhua Wang, Leaf Huang
Exosomes are small membrane-bound vesicular particles generated by most cells for intercellular communication and regulation. During biogenesis, specific lipids, RNAs, proteins, and carbohydrates are enriched and packaged into the vesicles so that the exosomal contents reflect not only the source but also the physiological conditions of the parental cells. These exosomes transport materials or signals to the target cells for diverse physiological purposes. Our study focused on the exosomes derived from M1-polarized, proinflammatory macrophages for the possibility of using M1 exosomes as an immunopotentiator for a cancer vaccine...
March 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
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