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Valentina Grippo, Su Ma, Roland Ludwig, Lo Gorton, Renata Bilewicz
Lipidic cubic phase systems (LCPs) are excellent carriers for immobilized enzymes due to their biocompatibility and well-defined nanoporous structure. Lipidic cubic phases act as a convenient matrix to incorporate enzymes and hold them in the vicinity of electrode surfaces in their fully active forms. Corynascus thermophilus cellobiose dehydrogenase (CtCDH) was trapped in a monoolein cubic phase, which increased not only its stability, but also its catalytic performance with both enhanced mediated and direct electron transfer with electrodes...
October 13, 2017: Bioelectrochemistry
Giandavide Ieropoli, Jorge Hugo Villafañe, Silvia Chiara Zompi, Umberto Morozzo, Riccardo D'Ambrosi, Federico Giuseppe Usuelli, Pedro Berjano
OBJECTIVE: The aim is to present a case series that illustrates possible benefits from combining minimally invasive plate osteosynthesis (MIPO), plastic surgery and antibiotic therapy, in order to treat and eradicate infection in patients with tibial pilon or calcaneal fractures. METHODS: Eleven consecutive patients with dehiscence of the surgical wound in outcomes MIPO using a Locking Compression Plate (LCP) for tibial pilon, or calcaneus fractures. The patients had developed a documented infection of the surgical wound...
October 23, 2017: Foot
Chuanbo Fu, Li Dan
The ground observation data was used to analyze the variation of cloud amount and light precipitation over South China during 1960-2009. The total cloud cover (TCC) decreases in this period, whereas the low cloud cover (LCC) shows the obvious opposite change with increasing trends. LCP defined as low cloud cover/total cloud cover has increased, and small rainy days (< 10 mm day(-1)) decreased significantly (passing 0.001 significance level) during the past 50 years, which is attributed to the enhanced levels of air pollution in the form of anthropogenic aerosols...
November 9, 2017: Environmental Science and Pollution Research International
Shilpa Dawre, Sulabha Pathak, Shobhona Sharma, Padma V Devarajan
The World Health Organization (WHO) recommends artemisinin-based combination therapy (ACT) for treatment of falciparum malaria. Arteether (ART), an artemisinin derivative, is effective against Plasmodium falciparum, but it is available only as painful oily intramuscular (i.m.) injections. We formulated lyotropic liquid crystalline preconcentrates of ART and Lumefantrine (LUM) ACT with and without biodegradable polymer for antimalarial therapy. Following i.m. injection, both formed intact gels in situ due to rapid transition into liquid crystalline phase (LCP) which was confirmed by small angle neutron scattering (SANS), x-ray diffraction (XRD), polarization optical microscopy (POM) and rheological changes...
November 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
Marco Marcello, Martin Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, David Joseph, James Denham
BACKGROUND AND PURPOSE: To evaluate the impact of treatment planning and delivery factors on treatment outcome as measured by post-treatment disease progression. MATERIALS AND METHODS: Accruing 813 external beam radiotherapy participants during 2003-2007, the RADAR trial collected a comprehensive range of clinical treatment factor data for each participant. Both the Fine and Gray competing risks modelling and the Kaplan-Meier (KM) analysis were undertaken to determine the impact of these factors on local-composite progression (LCP), with 709 participants available for analysis...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Josip Knežević, Janoš Kodvanj, Fabijan Čukelj, Frane Pamuković, Arsen Pavić
PURPOSE: To compare the finite element models of two different composite radius fracture patterns, reduced and stabilised with four different fixed-angle dorsal plates during axial, dorsal and volar loading conditions. METHODS: Eight different plastic models representing four AO/ASIF type 23-A3 distal radius fractures and four AO/ASIF 23-C2 distal radius fractures were obtained and fixed each with 1 of 4 methods: a standard dorsal non-anatomical fixed angle T-plate (3...
November 2017: Injury
Ngai-Yin Chan, Ho-Chuen Yuen, Ngai-Shing Mok
Leadless cardiac pacemakers (LCP) have become available recently. Both its acute and long-term performance in a large population of patients remain to be tested. Subacute rise in pacing threshold has been reported as an uncommon complication. On the other hand, the retrieval technique for LCP with passive fixation mechanism has not been previously described in details. Herein we report a newly recognized complication of an acute rise in pacing threshold very soon after implantation of an LCP without radiographic dislodgement...
October 28, 2017: Indian Pacing and Electrophysiology Journal
Robert T Gale, Franco K K Li, Tianjun Sun, Natalie C J Strynadka, Eric D Brown
Gram-positive bacteria endow their peptidoglycan with glycopolymers that are crucial for viability and pathogenesis. However, the cellular machinery that executes this function is not well understood. While decades of genetic and phenotypic work have highlighted the LytR-CpsA-Psr (LCP) family of enzymes as cell-wall glycopolymer transferases, their in vitro characterization has been elusive, largely due to a paucity of tools for functional assays. In this report, we synthesized authentic undecaprenyl diphosphate-linked wall teichoic acid (WTA) intermediates and built an assay system capable of monitoring LCP-mediated glycopolymer transfer...
October 12, 2017: Cell Chemical Biology
Deokyeong Choe, Young Min Kim, Jae Eun Nam, Keonwook Nam, Chul Soo Shin, Young Hoon Roh
Developing hydrogels with enhanced mechanical strength is desirable for bio-related applications. For such applications, cellulose is a notable biopolymer for hydrogel synthesis due to its inherent strength and stiffness. Here, we report the viscosity-adjusted synthesis of a high-strength hydrogel through the physical entanglement of microcrystalline cellulose (MCC) in a solvent mixture of tetrabutylammonium fluoride/dimethyl sulfoxide (TBAF/DMSO). MCC was strategically dissolved with TBAF in DMSO at a controlled ratio to induce the formation of a liquid crystalline phase (LCP), which was closely related to the viscosity of the cellulose solution...
January 15, 2018: Carbohydrate Polymers
Johannes Oppermann, Linda Ettmann, Carolin Meyer, Christian Ries, Gregor Stein, Christian Karl Spies, Lars Peter Müller, Christoph Faymonville
BACKGROUND: A common method in surgical treatment of midshaft clavicular fractures is the clavicle plating system. In addition to traditional osteosynthetic devices, anatomically preformed plate systems also exist. Advantages are described in greater accuracy of fit and less irritation of surrounding soft tissues. The purpose of this study was to compare the anatomical fit of five different precontoured clavicle plating systems. MATERIAL AND METHODS: The anatomical fit of five different types of anatomical precontoured clavicle plates, 3 times VariaxSystem® (Stryker, Kalamazoo, MI), Meves® Plate (Ulrich medical Ulm, Germany) and LCP clavicle plate (Synthes, Bettlach, Switzerland) were investigated in 20 embalmed human cadaveric clavicles...
November 2, 2017: Der Unfallchirurg
Qi Liu, Hongda Zhu, Yun Liu, Sara Musetti, Leaf Huang
Approximately, 50% of human melanomas are driven by BRAF mutations, which produce tumors that are highly immunosuppressive and often resistant to vaccine therapy. We introduced lipid-coated calcium phosphate nanoparticles (LCP NPs) as a carrier to efficiently deliver a tumor-specific antigen, the BRAF(V600E) peptide, to drive dendritic cell (DC) maturation and antigen presentation in C57BL6 mice. The BRAF peptide vaccine elicited a robust, antigen-specific cytotoxic T cell response and potent tumor growth inhibition in a murine BRAF-mutant melanoma model...
November 1, 2017: Cancer Immunology, Immunotherapy: CII
Jiang-Jun Zhou, Min Zhao, Da Liu, Hai-Ying Liu, Cheng-Fei Du
In this study, we developed and validated a refined three-dimensional finite element model of middle femoral comminuted fracture to compare the biomechanical stability after two kinds of plate fixation: a newly designed assembly locking compression plate (NALCP) and a locking compression plate (LCP). CT data of a male volunteer was converted to middle femoral comminuted fracture finite element analysis model. The fracture was fixated by NALCP and LCP. Stress distributions were observed. Under slow walking load and torsion load, the stress distribution tendency of the two plates was roughly uniform...
2017: Journal of Healthcare Engineering
Rafael Carbonell-Escobar, Juan C Rubio-Suarez, Aitor Ibarzabal-Gil, E Carlos Rodriguez-Merchan
OBJECTIVE: To assess variables that could be related to outcomes in fractures of the tibial pilon treated by open reduction and internal fixation (ORIF). DESIGN: Retrospective. SETTING: University Hospital. PATIENTS: A total 92 fractures of the tibial pilon treated by ORIF in a 5-year period. The minimum follow-up was 1 year (mean: 3.3 years; range: 1-5). INTERVENTION: ORIF with LCP-LISS plate...
October 2017: Journal of Clinical Orthopaedics and Trauma
Malkesh D Shah, Chirag S Kapoor, Rishit J Soni, Jagdish J Patwa, Paresh P Golwala
INTRODUCTION: Pertrochanteric fractures are most frequent factures of the proximal femur, accounts for nearly 50% of all proximal femur fractures and are most devastating and also a major cause of disability in elderly. The aim and objective of this study was to evaluate the role of proximal femoral locking compression plate in unstable proximal femur fractures. MATERIAL AND METHOD: A total of 20 cases were included in our study (M:F - 16:4), who suffered proximal femur fracture due to various modalities and all of them were operated using proximal femoral locking compression plate...
October 2017: Journal of Clinical Orthopaedics and Trauma
Jungmin Seo, Gwang Jin Choi, Sangwan Park, Jihun Lee, Changhoon Baek, Jungwoo Jang, Jaegook Lim, Soowon Shin, Kangmoon Seo, Jong-Mo Seo, Yoon-Kyu Song, Sung June Kim
A polymer-based implantable stimulator for wirelessly navigating pigeons was conceptually suggested and a pilot study using depth electrodes was conducted. In this study, depth electrodes based on liquid crystal polymer (LCP) with eight channels were designed and fabricated. Electrochemical impedance spectrum (EIS) assessments were performed to measure impedances of the electrodes. The average value of the measured impedances was 16.8∠15.8 ° kμ. The electrodes were then advanced to a target nucleus (formatio reticularis medialis mesencephalic, FRM) of a pigeon to prove their in vivo feasibilities...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
A Maresca, P Sangiovanni, S Cerbasi, R Politano, R Fantasia, M Commessatti, R Pascarella
AIM: The aim of this study was to evaluate nonunion causes of surgically treated humeral shaft fractures in two different trauma centers. METHODS: A total of 327 cases of humeral shaft fractures were treated in 11 years in two trauma centers. We retrospectively reviewed in detail some factors in order to understand the reasons for nonunion: (1) fracture type, according to the AO classification, (2) grade of open fracture, according to Gustilo-Anderson, (3) timing, (4) reduction and (5) fixation...
October 19, 2017: Musculoskeletal Surgery
Gyeong-Won Jeong, Jae-Woon Nah
For efficient gene delivery, non-viral vectors should have high cellular uptake, excellent endosomal escape, and the ability to rapidly release the gene into the cytoplasm. Here, we developed a disulfide bond-conjugated bioreducible LMWSC-g-bPEI (LCP) composed of low molecular-weight water soluble chitosan (LMWSC), bPEI, and cystamine (Cys). The developed LCP had advantages such as low toxicity, great endosomal escape, and rapid release of pDNA into the cytoplasm. The polyplexes with LCP showed higher uptake into the nucleus and greater transfection efficiency than that without disulfide bond...
December 15, 2017: Carbohydrate Polymers
Giuseppe Rollo, Giovanni Vicenti, Roberto Rotini, Antonella Abate, Antonio Colella, Antonio D'Arienzo, Massimiliano Carrozzo, Biagio Moretti
We investigated functional and radiological outcome in 57 cases of midshaft clavicle nonunion treated with open reduction and internal fixation with plate and screws over a 13 year-period. Intercalary bone graft was used in 42 patients; opposite autologous strut graft was used in 31 cases to provide mechanical support to the host bone. Patients were analysed using chart and radiological review and assessed with DASH questionnaire obtained at the latest follow-up. 37 patients were male while 20 were females, with a mean age of 35 years (63-17)...
October 2017: Injury
Akbar Zubairi, Rizwan Haroon Rashid, Marij Zahid, Pervaiz Mahmood Hashmi, Shahryar Noordin
INTRODUCTION: Proximal femur locking compression plates (PF-LCP) have gained popularity since their inception due to superior biomechanical stability and durability but clinical experience has shown conflicting results including implant failure. OBJECTIVE: To study the incidence of implant failure in patients with sub-trochanteric fractures managed with proximal femoral locking compression plate and identify potential risk factors associated with the failure. MATERIALS & METHODS: Fifty patients with sub-trochanteric fractures, operated upon with titanium PF-LCP were included in the study from January 2012 to December 2014...
2017: Open Orthopaedics Journal
Daniela Lazo-Cancino, Selim S Musleh, Cristian E Hernandez, Eduardo Palma, Enrique Rodriguez-Serrano
BACKGROUND: Fragmentation of native forests is a highly visible result of human land-use throughout the world. In this study, we evaluated the effects of landscape fragmentation and matrix features on the genetic diversity and structure of Oligoryzomys longicaudatus, the natural reservoir of Hantavirus in southern South America. We focused our work in the Valdivian Rainforest where human activities have produced strong change of natural habitats, with an important number of human cases of Hantavirus...
2017: PeerJ
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