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cardiovascular progenitor cell

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https://www.readbyqxmd.com/read/28223221/the-atheroma-plaque-secretome-stimulates-the-mobilization-of-endothelial-progenitor-cells-ex-vivo
#1
Francisco M Vega, Violette Gautier, Cecilia M Fernandez-Ponce, Mª Jesús Extremera, A F Maarten Altelaar, Jaime Millan, Juan C Tellez, Jose A Hernandez-Campos, Rosario Conejero, Jorge Bolivar, Ricardo Pardal, Francisco J Garcia-Cózar, Enrique Aguado, Albert J R Heck, Mª Carmen Duran-Ruiz
Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy individuals after direct contact with the factors released by carotid arteries complicated with atherosclerotic plaques (AP), in order to understand the mechanisms underlying the neovascularization and remodeling properties assigned to these cells...
February 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28195173/foxa2-identifies-a-cardiac-progenitor-population-with-ventricular-differentiation-potential
#2
Evan Bardot, Damelys Calderon, Francis Santoriello, Songyan Han, Kakit Cheung, Bharati Jadhav, Ingo Burtscher, Stanley Artap, Rajan Jain, Jonathan Epstein, Heiko Lickert, Valerie Gouon-Evans, Andrew J Sharp, Nicole C Dubois
The recent identification of progenitor populations that contribute to the developing heart in a distinct spatial and temporal manner has fundamentally improved our understanding of cardiac development. However, the mechanisms that direct atrial versus ventricular specification remain largely unknown. Here we report the identification of a progenitor population that gives rise primarily to cardiovascular cells of the ventricles and only to few atrial cells (<5%) of the differentiated heart. These progenitors are specified during gastrulation, when they transiently express Foxa2, a gene not previously implicated in cardiac development...
February 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28192087/endothelial-cell-markers-from-clinician-s-perspective
#3
REVIEW
Jelena Rakocevic, Dejan Orlic, Olivera Mitrovic-Ajtic, Miloje Tomasevic, Milan Dobric, Natasa Zlatic, Dejan Milasinovic, Goran Stankovic, Miodrag Ostojić, Milica Labudovic-Borovic
Endothelial cell markers are membrane-bound or cytoplasmic molecules expressed by endothelial cells, which help their easier identification and discrimination from other cell types. During vasculogenesis, endothelial cells differentiate from hemangioblasts to form new blood vessels. With the discovery of endothelial progenitor cells (EPC) and their ability to form new blood vessels, the term vasculogenesis is not only reserved for the embryonic development. Possibility of de novo blood vessel formation from EPC is now widely explored in different ischemic conditions, especially in cardiovascular medicine...
February 9, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28189115/n-3-polyunsaturated-fatty-acids-alleviate-high-glucose-mediated-dysfunction-of-endothelial-progenitor-cells-and-prevent-ischemic-injuries-both-in-vitro-and-in-vivo
#4
Shao-Chih Chiu, Che-Yi Chao, En-Pei Isabel Chiang, Jia-Ning Syu, Raymond L Rodriguez, Feng-Yao Tang
Hyperglycemia is associated with a reduced number of endothelial progenitor cells (EPCs) that impairs vascular function. Circulating EPCs play important roles in postnatal neovasculogenesis and the prevention of ischemic injury. Frequent consumption of fish oil (FO) that is abundant with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) is reportedly associated with an alleviation of diabetic complications and a lowered incidence of cardiovascular disease. The aim of this study was to examine whether N-3 polyunsaturated fatty acids such as EPA and DHA would reverse the high glucose-mediated dysfunction of EPCs in vitro and thereby prevent the ischemic injury that occurs under the hyperglycemic conditions in Type 2 diabetes (T2D) db(-/-) mice...
January 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28177697/dysfunction-of-endothelial-progenitor-cells-in-hyperlipidemic-rats-involves-the-increase-of-nadph-oxidase-derived-reactive-oxygen-species-production
#5
Ting-Bo Li, Jie-Jie Zhang, Bin Liu, Xiu-Ju Luo, Qi-Lin Ma, Jun Peng
NADPH oxidase (NOX) is a major source of reactive oxygen species (ROS) in the body and it plays a key role in mediation of oxidative injury in cardiovascular system. The purposes of this study are to evaluate the status of NOX in EPCs of hyperlipidemic rats and to determine whether NOX- derived ROS promotes the dysfunction of endothelial progenitor cells (EPCs). The rats were fed on high-fat diet for 8 weeks to establish a hyperlipidemic rat model, which showed the increased plasma lipids and the impaired functions of circulating EPCs (including the reduced abilities in migration and adhesion), accompanied by an increase in NOX activity and ROS production...
October 20, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28163951/a-review-on-the-relationship-between-aspirin-and-bone-health
#6
REVIEW
Kok-Yong Chin
Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28163831/endothelial-progenitor-cells-exploring-the-pleiotropic-effects-of-statins
#7
REVIEW
Kully Sandhu, Mamas Mamas, Robert Butler
Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct and or death after a myocardial infarction, prior to any significant change in lipid profile. Therefore, pleiotropic mechanisms, other than lowering lipid profile alone, must account for this effect. One such proposed pleiotropic mechanism is the ability of statins to augment both number and function of endothelial progenitor cells...
January 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28149914/endothelial-progenitor-cells-and-cardiovascular-risk-does-ageing-trump-all-other-factors
#8
COMMENT
Amaryllis H Van Craenenbroeck, Emeline M Van Craenenbroeck
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28115811/deficiency-of-endothelial-progenitor-cells-associates-with-graft-thrombosis-in-patients-undergoing-endovascular-therapy-of-dysfunctional-dialysis-grafts
#9
Tsung-Yan Chen, Lin Lin, Mu-Yang Hsieh, Jui-Cheng Kuo, Chia-Ling Wang, Ren-Huei Wang, Chao-Lun Lai, Po-Hsun Huang, Chih-Cheng Wu
BACKGROUND: The deficiency of endothelial progenitor cells has been demonstrated to be associated with cardiovascular events in patients undergoing dialysis. However, their correlation with dialysis graft outcomes remains unknown. The objective of this study was to investigate the relationship between circulating endothelial progenitor cells and dialysis graft outcomes. METHODS: After excluding 14 patients with acute coronary syndrome, decompensated heart failure or graft thrombosis in the prior three months, a total of 120 patients undergoing dialysis who underwent endovascular therapy of dysfunctional dialysis grafts were prospectively enrolled...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28114972/optimizing-mesoderm-progenitor-selection-and-three-dimensional-microniche-culture-allows-highly-efficient-endothelial-differentiation-and-ischemic-tissue-repair-from-human-pluripotent-stem-cells
#10
Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du, Jie Na
BACKGROUND: Generation of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, chemically defined culture system to efficiently and rapidly differentiate endothelial cells from human pluripotent stem cells by going through an MESP1 mesoderm progenitor stage. METHODS: Mesp1 is a key transcription factor that regulates the development of early cardiovascular tissue...
January 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28097739/cellular-plasticity-in-cardiovascular-development-and-disease
#11
REVIEW
Soumyashree Das, Kristy Red-Horse
Knowledge on cellular differentiation pathways is critical to understanding organ development, homeostasis, and disease. Studying cell differentiation and cell fate restrictions in these contexts can be done through lineage tracing experiments, which entail permanent labeling of a cell and all its progeny. Recent lineage experiments within the cardiovascular system have uncovered unexpected findings on cellular origins during organogenesis and cell plasticity during disease. For example, there is increasing evidence that multiple progenitor sources exist for a single cell type, and that cells have remarkable expansive capacities under disease settings...
January 18, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28089145/effect-of-exercise-training-on-endothelial-function-in-heart-failure-patients-a-systematic-review-meta-analysis
#12
M J Pearson, N A Smart
OBJECTIVE: Endothelial dysfunction contributes to the development and progression of cardiovascular disease and heart failure (HF) and is associated with an increased risk of mortality. Flow-mediated dilation (FMD) is widely utilised to assess endothelial function and is improved with exercise training in heart failure patients. The aim of this meta-analysis is to quantify the effect of exercise training in patients with heart failure. BACKGROUND: A large number of studies now exist that have examined endothelial function in patients with heart failure...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28067862/impact-of-indoxyl-sulfate-on-progenitor-cell-related-neovascularization-of-peripheral-arterial-disease-and-post-angioplasty-thrombosis-of-dialysis-vascular-access
#13
REVIEW
Chih-Cheng Wu, Szu-Chun Hung, Ko-Lin Kuo, Der-Cherng Tarng
Patients with chronic kidney disease (CKD) have an increased risk of vascular disease, which is associated with considerable health care costs. Vascular disease in CKD differs clinically and pathobiologically from that in patients with normal renal function. Besides the traditional risk factors, retention of uremic toxins contributes to the pathogenesis of vascular disease in patients with CKD. Indoxyl sulfate is a protein-bound uremic toxin and is inefficiently removed by conventional dialysis. Accumulating evidence suggests that indoxyl sulfate is a vascular toxin involved in atherosclerosis, arteriosclerosis, vascular calcification and vascular repair...
January 7, 2017: Toxins
https://www.readbyqxmd.com/read/28060837/beneficial-effects-of-reconstituted-high-density-lipoprotein-rhdl-on-circulating-cd34-cells-in-patients-after-an-acute-coronary-syndrome
#14
Catherine Gebhard, Eric Rhéaume, Colin Berry, Geneviève Brand, Anne-Elen Kernaleguen, Gabriel Théberge-Julien, Mohammad Afaque Alam, Candace Y W Lee, Laurianne Boileau, Malorie Chabot-Blanchet, Marie-Claude Guertin, Marc-André Lavoie, Jean Grégoire, Réda Ibrahim, Philippe L'Allier, Jean-Claude Tardif
BACKGROUND: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS). This study investigates the short-term effects of reconstituted HDL (rHDL) on circulating progenitor cells in patients with ACS. METHODS AND FINDINGS: The study population consisted of 33 patients with recent ACS: 20 patients from the ERASE trial (randomized to receive 4 weekly intravenous infusions of CSL-111 40 mg/kg or placebo) and 13 additional patients recruited as controls using the same enrolment criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28006782/indoxyl-sulfate-impairs-endothelial-progenitor-cells-and-might-contribute-to-vascular-dysfunction-in-patients-with-chronic-kidney-disease
#15
Cheng-Jui Lin, Chih-Jen Wu, Pei-Chen Wu, Chi-Feng Pan, Tuan-Jen Wang, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Hung-I Yeh
BACKGROUND/AIMS: Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with chronic kidney disease (CKD). We explored the effect of IS on human early endothelial progenitor cells (EPCs) and analyzed the correlation between serum IS levels and parameters of vascular function, including endothelial function in a CKD-based cohort. METHODS: A cross-sectional study with 128 stable CKD patients was conducted. Flow-mediated dilation (FMD), pulse wave velocity (PWV), ankle brachial index, serum IS and other biochemical parameters were measured and analyzed...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27974567/human-cytomegalovirus-requires-epidermal-growth-factor-receptor-signaling-to-enter-and-initiate-the-early-steps-in-the-establishment-of-latency-in-cd34-human-progenitor-cells
#16
Jung Heon Kim, Donna Collins-McMillen, Jason C Buehler, Felicia D Goodrum, Andrew D Yurochko
The establishment of human cytomegalovirus (HCMV) latency and persistence relies on the successful infection of hematopoietic cells, which serve as sites of viral persistence and contribute to viral spread. Here, using blocking antibodies and pharmacological inhibitors, we document that HCMV activation of the epidermal growth factor receptor (EGFR) and downstream phosphatidylinositol 3-kinase (PI3K) mediates viral entry into CD34(+) human progenitor cells (HPCs), resulting in distinct cellular trafficking and nuclear translocation of the virus compared to that in other immune cells, such as we have documented in monocytes...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27968848/effect-of-danhong-injection-on-the-mobilisation-of-endothelial-progenitor-cells-to-vascular-repair-after-percutaneous-coronary-intervention-a-randomised-controlled-trial
#17
Zhen Hu, Hong Wang, Guanwei Fan, Han Zhang, Xiaoying Wang, Jingyuan Mao, Yingqiang Zhao, Yi An, Yuhong Huang, Chuan Li, Lianying Chang, Xianming Chu, Li Li, Yanfen Li, Yuan Zhang, Gangjian Qin, Xiumei Gao, Boli Zhang
BACKGROUND: Endothelial progenitor cells (EPCs) derived from bone marrow are associated with the repair of vascular injury by accelerating re-endothelisation, and represent a potential therapeutic target for ischaemic disease. Danhong injection (DHI), a Chinese Materia Medica standardised product extracted from Radix Salvia miltiorrhiza and Flos Carthamus tinctorius L, is effective in the treatment of ischaemic heart disease. We assessed the effect of DHI on the mobilisation of EPCs and vascular repair mediated by EPCs after percutaneous coronary intervention (PCI)...
October 2016: Lancet
https://www.readbyqxmd.com/read/27959616/coronary-artery-development-progenitor-cells-and-differentiation-pathways
#18
Bikram Sharma, Andrew Chang, Kristy Red-Horse
Coronary artery disease (CAD) is the number one cause of death worldwide and involves the accumulation of plaques within the artery wall that can occlude blood flow to the heart and cause myocardial infarction. The high mortality associated with CAD makes the development of medical interventions that repair and replace diseased arteries a high priority for the cardiovascular research community. Advancements in arterial regenerative medicine could benefit from a detailed understanding of coronary artery development during embryogenesis and of how these pathways might be reignited during disease...
February 10, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/27959432/bone-marrow-derived-mesenchymal-stem-cells-modified-with-igfbp-3-inhibit-the-proliferation-of-pulmonary-artery-smooth-muscle-cells
#19
Ge Sheng Cheng, Yu Shun Zhang, Ting Ting Zhang, Lu He, Xing Ye Wang
Pulmonary arterial hypertension (PAH) is a common clinical cardiovascular disease, leading to the excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and endothelial cells, and is associated with a high mortality rate. Recently, stem- and progenitor cell-mediated gene therapies have provided a novel approach for the treatment of PAH. However, the function of human bone marrow-derived mesenchymal stem cells (hBM‑MSCs) modified with the insulin-like growth factor binding protein-3 (IGFBP-3) gene in the regulation of PAH is not yet fully understood...
January 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27956416/telomere-shortening-regenerative-capacity-and-cardiovascular-outcomes
#20
Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Naser Abdulhadi, Ayman Alkhoder, Malik Obideen, Pratik Pimple, Oleksiy Levantsevych, Heval Kelli, Amit Shah, Yan Sun, Brad Pearce, Michael Kutner, Qi Long, Laura Ward, Yi-An Ko, Kareem Hosny Mohammed, Jue Lin, Jinying Zhao, J Bremner, Jinhee Kim, Edmund Waller, Paolo Raggi, David Sheps, Arshed Quyyumi, Viola Vaccarino
RATIONALE: Leucocyte telomere length (LTL) is a biological marker of aging, and shorter LTL is associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as a mechanism. Bone marrow-derived circulating progenitor cells (PCs) are involved in tissue repair and regeneration. OBJECTIVE: To examine the relationship between LTL and PCs, and their impact on adverse cardiovascular outcomes. METHODS AND RESULTS: We measured LTL by quantitative PCR in 566 outpatients (age 63±9 years, 76% male) with coronary artery disease (CAD)...
December 12, 2016: Circulation Research
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