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cardiovascular progenitor cell

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https://www.readbyqxmd.com/read/29767793/inhalation-of-house-dust-and-ozone-alters-systemic-levels-of-endothelial-progenitor-cells-oxidative-stress-and-inflammation-in-elderly-subjects
#1
Kim Jantzen, Annie Jensen, Ali Kermanizadeh, Grethe Elholm, Torben Sigsgaard, Peter Møller, Martin Roursgaard, Steffen Loft
Ambient air pollution including ozone and especially particulate matter represents important causes of cardiovascular disease. However, there is limited knowledge on indoor air dust with respect to this risk and the potential interactions between dust and ozone. Here, we exposed 23 healthy elderly subjects for 5.5 h, to either clean air, house dust at 275 µg/m3 (diameter < 2.5 µm), ozone at 100 ppb or combined house dust and ozone in a double-blinded randomized cross-over study. The combined house dust and ozone exposure was associated with a 48% (95% CI 24%-65%) decrease as compared with the clean air exposure, in CD34+KDR+ late endothelial progenitor cells (EPCs) per leukocyte in the blood shortly after exposure, whereas none of the single exposures resulted in a significant effect...
May 14, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29763891/endothelial-progenitor-cells-and-kidney-diseases
#2
Abdullah Ozkok, Alaattin Yildiz
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD)...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29760721/decreased-count-and-dysfunction-of-circulating-epcs-in-postmenopausal-hypercholesterolemic-females-via-reducing-no-production
#3
Ying Luo, Quan-Neng Yan, Wan-Zhou Wu, Fan-Yan Luo
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29750888/adiponectin-enhances-biological-functions-of-vascular-endothelial-progenitor-cells-through-the-mtor-stat3-signaling-pathway
#4
Xiaoying Dong, Xia Yan, Wei Zhang, Shengqiu Tang
Adiponectin (APN), an adipose tissue-excreted adipokine, plays protective roles in metabolic and cardiovascular diseases. In this study, the effects and mechanisms of APN on biological functions of rat vascular endothelial progenitor cells (VEPCs) were investigated in vitro. After administrating APN in rat VEPCs, the proliferation was measured by methyl thiazolyl tetrazolium (MTT) method, the apoptotic rate was test by Flow cytometry assay, mRNA expression of B-cell lymphoma-2 (Bcl-2) and vascular endothelial growth factor (VEGF) was determined by Real-time reverse transcriptase polymerase chain reaction (RT-PCR), and protein expression of mechanistic target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3) and phospho-STAT3 (pSTAT3) was analyzed by Western Blot...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29743563/cell-therapy-trials-for-heart-regeneration-lessons-learned-and-future-directions
#5
REVIEW
Philippe Menasché
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT+ cardiac stem cells, cardiosphere-derived cells, and cardiovascular progenitor cells derived from embryonic stem cells. Although the safety of cell therapies has been consistently reported, their efficacy remains more elusive...
May 9, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29741564/replacement-of-dietary-saturated-fat-with-unsaturated-fats-increases-numbers-of-circulating-endothelial-progenitor-cells-and-decreases-numbers-of-microparticles-findings-from-the-randomized-controlled-dietary-intervention-and-vascular-function-divas-study
#6
Michelle Weech, Hana Altowaijri, Jordi Mayneris-Perxachs, Katerina Vafeiadou, Jacqueline Madden, Susan Todd, Kim G Jackson, Julie A Lovegrove, Parveen Yaqoob
Background: Endothelial progenitor cells (EPCs) and microparticles are emerging as novel markers of cardiovascular disease (CVD) risk, which could potentially be modified by dietary fat. We have previously shown that replacing dietary saturated fatty acids (SFAs) with monounsaturated or n-6 (ω-6) polyunsaturated fatty acids (MUFAs or PUFAs, respectively) improved lipid biomarkers, blood pressure, and markers of endothelial activation, but their effects on circulating EPCs and microparticles are unclear...
May 8, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29739448/associations-between-endothelial-progenitor-cells-clinical-characteristics-and-coronary-restenosis-in-patients-undergoing-percutaneous-coronary-artery-intervention
#7
Fernando S Montenegro, Marcelo Correia, Fabiana Muccillo, Christina G Souza E Silva, Andrea De Lorenzo
OBJECTIVE: Endothelial progenitor cells (EPCs) are produced in the bone marrow and mobilized to the peripheral blood playing a key role in endothelial repair. The objective of this study was to evaluate circulating EPC before and after percutaneous coronary intervention (PCI) with stent implantation and their associations with coronary restenosis and adverse cardiovascular events. Venous blood was obtained before and the day after PCI. Quantification of total white blood count and identification of EPCs (CD45- CD34+ CD31+ CD133/2+ CD309+ ) through immunophenotyping by flow cytometry was performed...
May 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29738536/statins-impact-primary-embryonic-mouse-neural-stem-cell-survival-cell-death-and-fate-through-distinct-mechanisms
#8
Ross A Carson, Anthony C Rudine, Serena J Tally, Alexis L Franks, Krystle A Frahm, Jacob K Waldman, Neerupma Silswal, Suban Burale, James V Phan, Uma R Chandran, A Paula Monaghan, Donald B DeFranco
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway (CBP), and are used for the prevention of cardiovascular disease. The anti-inflammatory effects of statins may also provide therapeutic benefits and have led to their use in clinical trials for preeclampsia, a pregnancy-associated inflammatory condition, despite their current classification as category X (i.e. contraindicated during pregnancy). In the developing neocortex, products of the CBP play essential roles in proliferation and differentiation of neural stem-progenitor cells (NSPCs)...
2018: PloS One
https://www.readbyqxmd.com/read/29728415/crispr-mediated-gene-editing-to-assess-the-roles-of-tet2-and-dnmt3a-in-clonal-hematopoiesis-and-cardiovascular-disease
#9
Soichi Sano, Kousei Ohshima, Ying Wang, Yasufumi Katanasaka, Miho Sano, Kenneth Walsh
<u>Rationale:</u> Clonal hematopoiesis has been associated with increased mortality and cardiovascular disease (CVD). This condition can arise from somatic mutations in pre-leukemic driver genes within hematopoietic stem/progenitor cells (HSPC). Approximately 40 candidate driver genes have been identified, but mutations in only one of these genes, Ten-Eleven Translocation-2 (TET2), has been shown to casually contribute to CVD in murine models. <u>Objective:</u> To develop a facile system to evaluate the disease characteristics of different clonal hematopoiesis driver genes using lentivirus vector and CRISPR/Cas9 methodology...
May 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29724198/the-synergistic-effects-of-saxagliptin-and-metformin-on-cd34-endothelial-progenitor-cells-in-early-type-2-diabetes-patients-a-randomized-clinical-trial
#10
Fiona J Dore, Cleyton C Domingues, Neeki Ahmadi, Nabanita Kundu, Yana Kropotova, Sara Houston, Carol Rouphael, Aytan Mammadova, Linda Witkin, Anamil Khiyami, Richard L Amdur, Sabyasachi Sen
AIMS: Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition of saxagliptin, a DPP-IV inhibitor, to metformin, may reduce cardiovascular disease risk in addition to improving glycemic control in Type 2 diabetes patients. METHODS: In 12 week, double-blind, randomized placebo-controlled trial, 42 subjects already taking metformin 1-2 grams/day were randomized to placebo or saxagliptin 5 mg...
May 3, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29708992/genetic-profiling-of-young-and-aged-endothelial-progenitor-cells-in-hypoxia
#11
Tzu-Wei Wu, Chun-Chieh Liu, Chung-Lieh Hung, Chih-Hsien Yen, Yih-Jer Wu, Li-Yu Wang, Hung-I Yeh
Age is a major risk factor for diseases caused by ischemic hypoxia, such as stroke and coronary artery disease. Endothelial progenitor cells (EPCs) are the major cells respond to ischemic hypoxia through angiogenesis and vascular remodeling. However, the effect of aging on EPCs and their responses to hypoxia are not well understood. CD34+ EPCs were isolated from healthy volunteers and aged by replicative senescence, which was to passage cells until their doubling time was twice as long as the original cells...
2018: PloS One
https://www.readbyqxmd.com/read/29695981/cardiac-restoration-stemming-from-the-placenta-tree-insights-from-fetal-and-perinatal-cell-biology
#12
REVIEW
Sveva Bollini, Antonietta R Silini, Asmita Banerjee, Susanne Wolbank, Carolina Balbi, Ornella Parolini
Efficient cardiac repair and ultimate regeneration still represents one of the main challenges of modern medicine. Indeed, cardiovascular disease can derive from independent conditions upsetting heart structure and performance: myocardial ischemia and infarction (MI), pharmacological cardiotoxicity, and congenital heart defects, just to name a few. All these disorders have profound consequences on cardiac tissue, inducing the onset of heart failure over time. Since the cure is currently represented by heart transplantation, which is extremely difficult due to the shortage of donors, much effort is being dedicated to developing innovative therapeutic strategies based on stem cell exploitation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29672621/imbalance-between-endothelial-damage-and-repair-capacity-in-chronic-obstructive-pulmonary-disease
#13
Jéssica García-Lucio, Victor I Peinado, Lluís de Jover, Roberto Del Pozo, Isabel Blanco, Cristina Bonjoch, Núria Coll-Bonfill, Tanja Paul, Olga Tura-Ceide, Joan Albert Barberà
BACKGROUND: Circulating endothelial microparticles (EMPs) and progenitor cells (PCs) are biological markers of endothelial function and endogenous repair capacity. The study was aimed to investigate whether COPD patients have an imbalance between EMPs to PCs compared to controls and to evaluate the effect of cigarette smoke on these circulating markers. METHODS: Circulating EMPs and PCs were determined by flow cytometry in 27 nonsmokers, 20 smokers and 61 COPD patients with moderate to severe airflow obstruction...
2018: PloS One
https://www.readbyqxmd.com/read/29652803/hypoxia-supports-epicardial-cell-differentiation-in-vascular-smooth-muscle-cells-through-the-activation-of-the-tgf%C3%AE-pathway
#14
Jiayi Tao, Joey V Barnett, Michiko Watanabe, Diana Ramírez-Bergeron
Epicardium-derived cells (EPDCs) are an important pool of multipotent cardiovascular progenitor cells. Through epithelial-to-mesenchymal-transition (EMT), EPDCs invade the subepicardium and myocardium and further differentiate into several cell types required for coronary vessel formation. We previously showed that epicardial hypoxia inducible factor (HIF) signaling mediates the invasion of vascular precursor cells critical for patterning the coronary vasculature. Here, we examine the regulatory role of hypoxia (1% oxygen) on EPDC differentiation into vascular smooth muscle cells (VSMCs)...
April 13, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29651212/correlation-between-intron-4-polymorphism-of-the-endothelial-nitric-oxide-synthase-gene-and-cardiovascular-risk-with-the-numbers-of-circulating-endothelial-progenitor-cells-in-healthy-subjects
#15
Upasana Rishiraj, Sumati Rohilla, Savneet Kaur
In the present study, we investigated the relationship between an important 27 bp repeat polymorphism in intron 4 of eNOS and numbers of circulating EPCs in presence of cardiovascular disease (CVD) risk factors in a group of healthy human volunteers. The study comprised of 45 healthy subjects (30-50 years). These subjects had various degrees of CVD risk but no history of CVD. The repeat polymorphism of eNOS was detected by polymerase chain reaction and EPC levels were analyzed by flow cytometry. We observed a good association between the intronic 4 mutant a/b genotype and the combined Framingham risk factor score in our subjects (χ2  = 3...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29625872/construction-of-scaffolds-composed-of-acellular-cardiac-extracellular-matrix-for-myocardial-tissue-engineering
#16
Kamyar Esmaeili Pourfarhangi, Shohreh Mashayekhan, Sasan Ghanbari Asl, Zahra Hajebrahimi
High rates of mortality and morbidity stemming from cardiovascular diseases unveil extreme limitations in current therapies despite enormous advances in medical and pharmaceutical sciences. Following myocardial infarction (MI), parts of myocardium undergo irreversible remodeling and is substituted by a scar tissue which eventually leads to heart failure (HF). To address this issue, cardiac patches have been utilized to initiate myocardial regeneration. In this study, a porous cardiac patch is fabricated using a mixture of decellularized myocardium extracellular matrix (ECM) and chitosan (CS)...
April 3, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29604296/circulating-cd34-and-cd34-vegfr2-progenitor-cells-are-associated-with-klotho-kl-vs-polymorphism
#17
Maria Skrzypkowska, Bartosz Słomiński, Monika Ryba-Stanisławowska, Piotr Gutknecht, Janusz Siebert
BACKGROUND: KLOTHO is a regulator of endothelial cells activity and integrity. It has been described for the first time because of its anti-aging properties. KLOTHO encoding gene is present in many functional variants in humans, including "KL-VS" variant that has been connected with longevity and cardiovascular disease development. Few mechanisms have been proposed to explain these associations, but none of them focused on cells from CD34+ population. The aim of our study was to investigate influence of KLOTHO KL-VS polymorphism on populations of CD34+ and CD34+VEGFR2+ cells...
March 28, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29601312/myeloid-cells-regulate-plasma-ldl-cholesterol-levels
#18
Venetia Bazioti, Anouk M La Rose, Marit Westerterp
PURPOSE OF REVIEW: Leukocytosis, elevated blood leukocyte levels, is associated with enhanced cardiovascular risk in humans. Hematopoietic stem and progenitor cells (HSPCs) drive leukocyte production in a process called hematopoiesis, which mainly occurs in the bone marrow, and under certain conditions also in other organs such as the spleen. Cholesterol accumulation in HSPCs enhances hematopoiesis, increasing levels of blood monocytes that infiltrate into atherosclerotic plaques. Although HSPC proliferation and monocytosis enhance atherogenesis in several studies, concomitant decreases in LDL-cholesterol levels have also been reported, associated with anti-atherogenic effects...
March 29, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29574800/high-salt-induced-excess-reactive-oxygen-species-production-resulted-in-heart-tube-malformation-during-gastrulation
#19
Lin-Rui Gao, Guang Wang, Jing Zhang, Shuai Li, Manli Chuai, Yongping Bao, Berthold Hocher, Xuesong Yang
An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E-cadherin/N-cadherin/Laminin and interfering with mesoderm formation during the epithelial-mesenchymal transition(EMT). Furthermore, the DiI+ cell migration trajectory in vivo and scratch wound assays in vitro indicated that high-salt exposure restricted cell migration of cardiac progenitors, which was caused by the weaker cytoskeleton structure and unaltered corresponding adhesion junctions at HH7...
March 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29535783/cardiac-progenitor-cells-in-basic-biology-and-regenerative-medicine
#20
REVIEW
Nevin Witman, Makoto Sahara
Major cardiovascular events including myocardial infarction (MI) continue to dominate morbidity rates in the developed world. Although multiple device therapies and various pharmacological agents have been shown to improve patient care and reduce mortality rates, clinicians and researchers alike still lack a true panacea to regenerate damaged cardiac tissue. Over the previous two to three decades, cardiovascular stem cell therapies have held great promise. Several stem cell-based approaches have now been shown to improve ventricular function and are documented in preclinical animal models as well as phase I and phase II clinical trials...
2018: Stem Cells International
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