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https://www.readbyqxmd.com/read/28945050/decreased-nitric-oxide-serum-level-after-pituitary-adenoma-resection
#1
Daniel Babula, Anna Horecka, Dorota Luchowska-Kocot, Joanna Kocot, Jacek Kurzepa
BACKGROUND: Nitric oxide (NO) is synthesized by the conversion of Arginine (Arg) into the NO and Citrulline (Cit). Although the NO is involved into the pathogenesis of several physiological and pathological processes, the role of NO in pituitary adenomas (PA) progres-sion is not determined. Our purpose was to evaluate the relationship between NO and PA as well as the effect of tumor resection on NO metabolites level in serum. METHODS: The study group consisted of 21 patients with PA, 18 patients with macroade-nomas and 3 with microadenomas...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945017/-a-strategy-of-constructing-the-technological-system-for-quality-control-of-chinese-medicine-based-on-process-control-and-management
#2
Yi-Yu Cheng, Zhong-Zhi Qian, Bo-Li Zhang
The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process control in drug regulation, reverse the situation of neglecting the development of process control and management technology for pharmaceutical manufacture and reconstruct the technological system for quality control of CM products. The regulation and technology system based on process control and management for controlling CM quality should be established to solve weighty realistic problems of CM industry from the root causes, including backwardness of quality control technology, weakness of quality risk control measures, poor reputation of product quality and so on...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944983/oral-prolonged-release-oxycodone-naloxone-for-managing-pain-and-opioid-induced-constipation-a-review-of-the-evidence
#3
REVIEW
Bart J Morlion, Stefan A Mueller-Lissner, Renato Vellucci, Wojciech Leppert, Benoît C Coffin, Sara L Dickerson, Tony O'Brien
BACKGROUND: Opioids provide effective relief from moderate-to-severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed-dose oxycodone/naloxone prolonged-release tablets (OXN PR) were designed to address the opioid class effect of opioid-induced constipation (OIC) by combining the analgesic efficacy of oxycodone with the opioid receptor antagonist, naloxone, which has negligible systemic availability when administered orally...
September 25, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28944980/failure-mode-and-effects-analysis-a-community-practice-perspective
#4
Bradley W Schuller, Angi Burns, Elizabeth A Ceilley, Alan King, Joan LeTourneau, Alexander Markovic, Lynda Sterkel, Brigid Taplin, Jennifer Wanner, Jeffrey M Albert
PURPOSE: To report our early experiences with failure mode and effects analysis (FMEA) in a community practice setting. METHODS: The FMEA facilitator received extensive training at the AAPM Summer School. Early efforts focused on department education and emphasized the need for process evaluation in the context of high profile radiation therapy accidents. A multidisciplinary team was assembled with representation from each of the major department disciplines. Stereotactic radiosurgery (SRS) was identified as the most appropriate treatment technique for the first FMEA evaluation, as it is largely self-contained and has the potential to produce high impact failure modes...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944965/comparison-of-psoriasis-and-atopic-dermatitis-guidelines-an-argument-for-aggressive-atopic-dermatitis-management
#5
Mary E Lohman, Peter A Lio
The development of effective systemic treatments has revolutionized the treatment of inflammatory skin diseases. The availability of safe new treatments and the understanding of psoriasis as a systemic disease with comorbidities and effects on quality of life have driven the current aggressive treatment paradigm of psoriasis. Historically the morbidity of atopic dermatitis (AD) has been dismissed, given the perception of AD as "just" a rash. Differences in the guidelines for psoriasis and AD management may suggest variations in the current conceptualization of disease severity and effects on quality of life...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28944947/posttraumatic-cerebral-infarction-after-decompressive-craniectomy-for-traumatic-brain-injury-incidence-risk-factors-and-outcome
#6
Tsung-Ming Su, Chu-Mei Lan, Tsung-Han Lee, Fu-Yuan Shih, Shih-Wei Hsu, Cheng-Hsien Lu
AIM: To investigate the incidence, timing, risk factors of posttraumatic cerebral infarction (PTCI) and its influence on mortality in patients with moderate to severe traumatic brain injury (TBI). MATERIAL AND METHODS: After reviewing the medical records and radiographs over a 6-year period, 173 patients with moderate to severe TBI were enrolled to determine the risk factors for the development of PTCI following unilateral decompressive craniectomy (DC). RESULTS: The incidence of PTCI following DC was 31...
July 23, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944938/-reverse-j-shaped-skin-flap-and-cranial-bone-groove-for-shunt-hardware-a-new-technique-in-patients-with-fragile-skin
#7
Murteza Cakir
INTRODUCTION: Shunt systems are not perfect devices and can cause severe complications. Complications may originate from problems related to the valve, the patient, or the surgery and more common in neonates, infants, especially preterm by reason of the special characteristics these patients owned. We therefore have succesfully developed useful and viable surgical technique in order to provide helpful aspects to surgical issues mentioned above. TECHNIQUE: This technique includes \"reverse J\" shaped skin incision with nonintersecting the shun's hardware and distal catheter and to be reduced the wound problems to the minimum rates by opening \"bone groove\"...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944916/total-glucosides-of-paeony-ameliorates-tnbs%C3%A2-induced-colitis-by-modulating-differentiation-of-th17-treg-cells-and-the-secretion-of-cytokines
#8
Haihua Lin, Wenyou Zhang, Xuepei Jiang, Renpin Chen, Xielin Huang, Zhiming Huang
The imbalance between effector CD4+ T helper 17 (Th17) and regulatory CD4+ T cells (Treg) cells and their associated cytokines, have been associated with the pathogenesis of inflammatory bowel disease (IBD). Total glycosides of paeony (TGP) is an alternative immunomodulatory agent that is widely used for the treatment of autoimmune diseases. The present study aimed to evaluate the modulatory effect of TGP in a rat model of colitis induced by 2,4,6‑trinitrobenzene sulfonic acid (TNBS). TGP was administered intragastrically 24 h after the TNBS intrarectal instillation for 7 days...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944910/sh003%C3%A2-induced-g1-phase-cell-cycle-arrest-induces-apoptosis-in-hela-cervical-cancer-cells
#9
Kang Min Lee, Kangwook Lee, Youn Kyung Choi, Yu-Jeong Choi, Hye-Sook Seo, Seong-Gyu Ko
Cervical cancer is a prevalent disease that may lead to mortality in women. In spite of the development of common therapeutic agents to treat cancer, there are several limitations of their use owing to side effects and drug resistance, which may induce cancer recurrence. The anticancer effects of the new herbal mixture SH003 (comprising Astragalus membranaceus, Angelica gigas and Trichosanthes kirilowii Maximowicz) have been examined in various types of cancer. Thus, the present study hypothesized that SH003 may be an effective treatment for cervical cancer...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944909/long-non%C3%A2-coding-rna-associated%C3%A2-competing-endogenous-rnas-are-induced-by-clusterin-in-retinal-pigment-epithelial-cells
#10
Zi Ye, Zhaohui Li, Shouzhi He
Age related macular degeneration is one of the most common causes of vision loss in the elderly. Long noncoding RNAs (lncRNAs) serve important roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs). However, the roles of specific lncRNAs and their associated ceRNA function induced by clusterin in cultured retinal pigment epithelial (RPE) cells remain to be fully elucidated. Based on high throughput sequencing data from RPE cells treated with or without clusterin, the present study identified differentially expressed mRNAs, lncRNAs and microRNAs (miRNAs)...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944900/circulating-mirna%C3%A2-21-is-a-promising-biomarker-for-heart-failure
#11
Jianghua Zhang, Qiang Xing, Xianhui Zhou, Jinxin Li, Yaodong Li, Lin Zhang, Qina Zhou, Baopeng Tang
microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. However, whether it can be used as a biomarker for the diagnosis and prognosis of heart failure remains unclear. The current study assessed circulating miRNA‑21 as a viable indicator for diagnosis and prognosis of heart failure. The levels of miRNA‑21 and brain natriuretic peptide were measured in serum obtained from the peripheral vein (miRNA‑21‑PV) and coronary sinus (miRNA‑21‑CS) of 80 patients with heart failure and 40 control individuals via reverse transcription‑quantitative polymerase chain reaction and ELISA, respectively...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944899/smilax-glabra-rhizoma-affects-the-pharmacokinetics-and-tissue-distribution-of-methotrexate-by-increasing-the-p%C3%A2-glycoprotein-mrna-expression-in-rats-after-oral-administration
#12
Yang Li, Shigui Deng, Ya Ζhao, Lijuan Liu, Ruizhi Zhao
Methotrexate (MTX) is a widely used immunosuppressant and anticancer agent with high toxicity. Smilax glabra Rhizoma (SGR) has the effect of detoxification and immunoregulation, and has been used as both food and folk medicine in many countries. Co‑administration of MTX and SGR occurs in several diseases. However, whether they work synergistically or are incompatible remains unknown. In the present study, MTX was administrated to rats alone or combined with SGR. Blood and tissue samples were collected at designated times...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944866/early-anticoagulation-therapy-for-severe-burns-complicated-by-inhalation-injury-in-a-rabbit-model
#13
Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
The aim of the present study was to determine the effects of early anticoagulation treatment on severe burns complicated by inhalation injury in a rabbit model. Under anesthetization, an electrical burns instrument (100˚C) was used to scald the backs of rabbits for 15 sec, which established a 30% III severe burns model. Treatment of the rabbits with early anticoagulation effectively improved the severe burns complicated by inhalation injury‑induced lung injury, reduced PaO2, PaCO2 and SPO2 levels, suppressed the expression of tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6, and increased the activity of IL‑10...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944863/microrna%C3%A2-509-acts-as-a-tumor-suppressor-in-tongue-squamous-cell-carcinoma-by-targeting-epidermal-growth-factor-receptor
#14
Chao Hou, Yan Dong, Fenghe Zhang, Bo Du
Tongue squamous cell carcinoma (TSCC) is the most frequent type of oral carcinoma, and is characterized by high metastatic and growth capabilities. Previous studies have demonstrated that aberrantly expressed cancer‑associated microRNAs (miRs) may be associated with tumorigenesis and tumor development in various types of cancer, including TSCC. miR‑509 has been identified as a critical regulator in tumorigenesis and tumor development, via its tumor‑suppressing actions in several types of human cancer...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944856/systemic-overexpression-of-the-11%C3%AE-%C3%A2-hsd1-promotes-endoplasmic-reticulum-stress-in-multiple-tissues-and-the-development-of-metabolic-syndrome-in-mice
#15
Chenxiao Li, Jihan Xia, Wenjuan Zhu, Leilei Xin, Cuiping An, Shulin Yang, Kui Li
Glucocorticoids are associated with lipid metabolism and their abnormal expression has an important function in the development of metabolic syndrome. The 11β‑hydroxysteroid dehydrogenase type 1 (11β‑HSD1) is a metabolic enzyme of glucocorticoids and may be a potential drug target for the treatment of metabolic syndrome. However, the association between the systemic expression of 11β‑HSD1 and metabolic syndrome remains to be elucidated. The present study used a cytomegalovirus promoter to obtain mice that systemically overexpressed the 11β‑HSD1 gene...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944853/kisspeptin-inhibits-cancer-growth-and-metastasis-via-activation-of-eif2ak2
#16
Tae-Hun Kim, Sung-Gook Cho
Kisspeptin is a protein encoded by the KISS1 gene, which has been reported to suppress the metastatic capabilities of various types of cancer cells, through the activation of its G‑protein coupled receptor GPR54. However, the molecular mechanisms underlying the involvement of kisspeptin‑mediated signaling in the inhibition of cancer cell migration and invasion have yet to be elucidated. The present in vitro cell proliferation, migration and invasion assays and in vivo experimental metastasis studies demonstrated that kisspeptin‑induced eukaryotic translation initiation factor 2α kinase 2 (EIF2AK2) activation suppressed the metastatic capabilities of several types of cancer cells...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944842/mitochondrial-dna%C3%A2-induced-inflammatory-damage-contributes-to-myocardial-ischemia-reperfusion-injury-in-rats-cardioprotective-role-of-epigallocatechin
#17
Chao-Yi Qin, Hong-Wei Zhang, Jun Gu, Fei Xu, Huai-Min Liang, Kang-Jun Fan, Jia-Yu Shen, Zheng-Hua Xiao, Er-Yong Zhang, Jia Hu
Inflammation serves an important role in the pathogenesis of myocardial ischemia/reperfusion (I/R) injury. Fragments of endogenous damaged‑associated molecular patterns, recently identified as mitochondrial DNA (mtDNA), have been proven to be a potent pro‑inflammatory mediator. Epigallocatechin‑3‑gallate (EGCG) is able to regulate the expression levels of a series of inflammatory cytokines. However, the involvement of endogenous mtDNA in EGCG‑regulated inflammatory activities in the context of myocardial I/R injury remains to be elucidated...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944839/alteration-of-oxidative-stress-and-inflammatory-cytokines-induces-apoptosis-in-diabetic-nephropathy
#18
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
Diabetic nephropathy (DN) is one of the most significant long‑term complications in terms of morbidity and mortality for diabetic patients; however, the exact cause remains unknown. To address this, the DN model was established, and oxidative stress indexes, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px), and inflammatory cytokines, includinginterleukin‑6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α) and transforming growth factor‑beta (TGF‑β), were examined by ELISA...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944836/aberrant-promoter-methylation-of-multiple-genes-in-vsmc-proliferation-induced-by-hcy
#19
Sheng-Chao Ma, Jian-Cheng Cao, Hui-Ping Zhang, Yun Jiao, Hui Zhang, Yang-Yang He, Yan-Hua Wang, Xiao-Ling Yang, An-Ning Yang, Jue Tian, Ming-Hao Zhang, Xiao-Ming Yang, Guan-Jun Lu, Shao-Ju Jin, Yue-Xia Jia, Yi-Deng Jiang
Vascular smooth muscle cell (VSMC) proliferation is a primary pathological event in atherosclerosis (AS), and homocysteine (Hcy) is an independent risk factor for AS. However, the underlying mechanisms are still lagging. Studies have used the combination of methylation of promoters of multiple genes to diagnose tumors, thus the aim of the current study was to investigate the role of methylation status of several genes in VSMCs treated with Hcy. CpG islands were identified in the promoters of platelet‑derived growth factor (PDGF), p53, phosphatase and tensin homologue on chromosome 10 (PTEN) and mitofusin 2 (MFN2)...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944832/icariin-improves-acute-kidney-injury-and-proteinuria-in-a-rat-model-of-pregnancy%C3%A2-induced-hypertension
#20
Wenyu Zhang, Wei Yuan, Ning Xu, Jinping Li, Wenxiu Chang
Icariin has previously been demonstrated to attenuate hyperglycemia‑induced renal injury, however the renoprotective effects of icariin in a rat model of pregnancy‑induced hypertension (PIH) remain to be elucidated. The present study aimed to investigate the effect of icariin on PIH‑induced acute kidney injury (AKI) and proteinuria. Following 18 days of icariin treatment between day 1 and day 18 of gestation, which was combined with NG‑nitro‑L‑arginine methyl ester (L‑NAME) treatment between day 12 and day 18 of gestation to induce PIH, the 24 h urine protein level, blood urea nitrogen and serum creatinine were measured by using the Coomassie Brilliant Blue method, a commercial enzymatic kit and the picric acid method, respectively...
September 19, 2017: Molecular Medicine Reports
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