Doris Illner, Roman Zinner, Violet Handtke, Jacques Rouquette, Hilmar Strickfaden, Christian Lanctôt, Marcus Conrad, Alexander Seiler, Axel Imhof, Thomas Cremer, Marion Cremer
Extensive changes of higher order chromatin arrangements can be observed during prometaphase, terminal cell differentiation and cellular senescence. Experimental systems where major reorganization of nuclear architecture can be induced under defined conditions, may help to better understand the functional implications of such changes. Here, we report on profound chromatin reorganization in fibroblast nuclei by chaetocin, a thiodioxopiperazine metabolite. Chaetocin induces strong condensation of chromosome territories separated by a wide interchromatin space largely void of DNA...
June 10, 2010: Experimental Cell Research