Tahliyah S Mims, Roshan Kumari, Cameron Leathem, Karen Antunes, Sydney Joseph, Mei-I Yen, Danielle Ferstl, Sophia M Jamieson, Austin Sabbar, Claudia Biebel, Nikolai Lazarevic, Nathaniel B Willis, Lydia Henry, Chi-Liang E Yen, Joseph P Smith, Ankush Gosain, Marlies Meisel, Kent A Willis, Ajay J Talati, Mohamad T Elabiad, Brianne Hibl, Joseph F Pierre
Parenteral nutrition (PN) prevents starvation and supports metabolic requirements intravenously when patients are unable to be fed enterally. Clinically, infants are frequently provided PN in intensive care settings along with exposure to antibiotics (ABX) to minimize infection during care. Unfortunately, neonates experience extremely high rates of hepatic complications Adult rodent and piglet models of PN are well-established, but neonatal models capable of leveraging the considerable transgenic potential of the mouse remain underdeveloped...
September 27, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology