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Gastric cancer mis

Tomaz Jagric, Katarina Mis, Maksimilijan Gorenjak, Ales Goropevsek, Rajko Kavalar, Tomaz Mars
BACKGROUND: The focused sentinel lymph node (SLN) concept we proposed previously relied on real time-quantitative polymerase chain reaction (RT-qPCR) to detect tumor cells, which is too elaborate for intraoperative use. Therefore, we evaluated flow cytometry for intraoperative detection of tumor cells in SLNs. METHODS: Sixty-five consecutive gastric cancer patients were included. SLN analysis was carried out for a single SLN from each patient, using the molecular methods of RT-qPCR (first 30 patients) and flow cytometry (final 35 patients)...
March 2018: Journal of Surgical Research
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
Won Jung Choi, Jin-Hee Moon, Jae Seok Min, Yong Keun Song, Seung A Lee, Jin Woo Ahn, Sang Hun Lee, Ha Chul Jung
BACKGROUND AND OBJECTIVES: During minimally invasive surgery (MIS), it is impossible to directly detect marked clips around tumors via palpation. Therefore, we developed a novel method and device using Radio Frequency IDentification (RFID) technology to detect the position of clips during minimally invasive gastrectomy or colectomy. METHODS: The feasibility of the RFID-based detection system was evaluated in an animal experiment consisting of seven swine. The primary outcome was to successfully detect the location of RFID clips in the stomach and colon...
November 28, 2017: Journal of Surgical Oncology
Jiyang Li, Hongqing Xi, Jianxin Cui, Kecheng Zhang, Yunhe Gao, Wenquan Liang, Aizhen Cai, Bo Wei, Lin Chen
BACKGROUND: As minimally invasive techniques advances, minimally invasive surgery (MIS) has emerged as an alternative modality for advanced gastric cancer. In this study, we compared the short- and long-term surgical outcomes of MIS and conventional open surgery for gastric cancer liver metastasis (GCLM) in terms of safety, feasibility, and efficacy. METHODS: This retrospective study used data from a prospective database at the Chinese People's Liberation Army General Hospital...
March 2018: Surgical Endoscopy
Chien-An Liu, Kuo-Hung Huang, Ming-Huang Chen, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr, Wen-Liang Fang
BACKGROUND: As life expectancy continues to increase around the world, the use of minimally invasive surgery (MIS) could be beneficial for octogenarian and older gastric cancer patients. METHODS: A total of 359 gastric cancer patients who underwent curative surgery between March 2011 and March 2015 were enrolled; 80 of these patients (22.2%) were octogenarians and older. Surgical approaches included MIS (50 laparoscopic and 65 robotic) and open surgery (n = 244)...
June 12, 2017: BMC Surgery
Meredith C Mason, Hop S Tran Cao, Samir S Awad, Farhood Farjah, George J Chang, Nader N Massarweh
OBJECTIVE: The aim of the study was to evaluate the impact of receiving care at high minimally invasive surgery (MIS)-utilizing hospitals BACKGROUND:: MIS techniques are used across surgical specialties. The extent of MIS utilization for gastrointestinal (GI) cancer resection and impact of receiving care at high utilizing hospitals is unclear. METHODS: This is a retrospective cohort study of 137,581 surgically resected esophageal, gastric, pancreatic, hepatobiliary, colon, and rectal cancer patients within the National Cancer Data Base (2010-2013)...
May 11, 2017: Annals of Surgery
Luke V Selby, Ronald P DeMatteo, Renee M Tholey, William R Jarnagin, Julio Garcia-Aguilar, Paul D Strombom, Peter J Allen, T Peter Kingham, Martin R Weiser, Murray F Brennan, Vivian E Strong
BACKGROUND: Patients and providers are increasingly interested in the utilization, safety, and efficacy of minimally invasive surgery (MIS). We reviewed 11 years of MIS resections (laparoscopic and robotic) for intra-abdominal malignancies. METHODS: Patients who underwent gastrectomy, distal pancreatectomy, hepatic resection, and colorectal resection between 2004 and 2014 were identified. Cases were categorized as open, laparoscopic, and robotic based on the initial operation approach...
March 2017: Journal of Surgical Oncology
Xin-Zu Chen, Yang Liu, Rui Wang, Wei-Han Zhang, Jian-Kun Hu
BACKGROUND: Following the appeal of the World Health Assembly for national cancer plans and programmes, the Chinese Ministry of Health issued governmental outlines of the National Cancer Prevention and Control Programme (2004-10). This study aimed to evaluate the efficacy of that programme in mainland China. METHODS: The Chinese Ministry of Health outlines aimed to establish a national cancer registry system, enhance the population health education, and organise prevention, early detection, and early treatment for principal cancers, especially in rural areas for high-incidence cancers...
October 2016: Lancet
Xin-Xin Liu, Hua-Feng Pan, Zhi-Wei Jiang, Shu Zhang, Zhi-Ming Wang, Ping Chen, Yan Zhao, Gang Wang, Kun Zhao, Jie-Shou Li
BACKGROUND: Enhanced recovery after surgery (ERAS) protocols or fast-track (FT) programs enable a shorter hospital stay and lower complication rate. Minimally invasive surgery (MIS) is associated with a lesser trauma and a quicker recovery in many elective abdominal surgeries. However, little is known of the safety and effectiveness made by ERAS protocols combined with MIS for gastric cancer. The purpose of this study was to evaluate the safety and effectiveness made by FT programs and MIS in combination or alone...
October 5, 2016: Chinese Medical Journal
Tomaz Jagric, Stojan Potrc, Katarina Mis, Mojca Plankl, Tomaz Mars
BACKGROUND: We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. PATIENTS AND METHODS: Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases...
June 1, 2016: Radiology and Oncology
Koichi Suda, Masaya Nakauchi, Kazuki Inaba, Yoshinori Ishida, Ichiro Uyama
Minimally invasive surgery (MIS) for upper gastrointestinal (GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes...
May 21, 2016: World Journal of Gastroenterology: WJG
Juhan Lee, Yoo-Min Kim, Yanghee Woo, Kazutaka Obama, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: Minimally invasive surgery (MIS) has emerged as a treatment of choice for early-stage gastric cancer. However, applying MIS to gastric patients with high body mass index (BMI) is technically challenging, especially when performing D2 lymphadenectomy. Recently, robotic systems have been adopted to overcome the technical limitations of conventional laparoscopic surgery. Nevertheless, studies on the impact of the use of robotic systems to perform D2 lymphadenectomy in high BMI patients are lacking...
November 2015: Surgical Endoscopy
In Gyu Kwon, In Cho, Ali Guner, Hyoung-il Kim, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: As life expectancy is increasing, the use of minimally invasive surgery (MIS) in the elderly is gaining interest. The aim of this study was to identify the impact of minimally invasive gastrectomy by comparing the procedure to open surgery in octogenarians. In addition, we also evaluated the role of gastrectomy in elderly gastric cancer patients by assessing long-term outcomes. METHODS: We retrospectively analyzed data from 99 gastric cancer patients aged 80 years or older, who underwent gastrectomy by either MIS or open surgery from 2005 to 2010...
August 2015: Surgical Endoscopy
S P Mönig, S H Chon, J Weindelmayer, G de Manzoni, A H Hölscher
Minimally invasive operative procedures are increasingly being used for treating tumors of the upper gastrointestinal tract. While minimally invasive surgery (MIS) has become established as a standard procedure for benign tumors and gastrointestinal stromal tumors (GIST) based on current studies, the significance of MIS in the field of gastric cancer is the topic of heated debate. Until now the majority of studies and meta-analyses on gastric cancer have come from Asia and these indicate the advantages of MIS in terms of intraoperative blood loss, minor surgical complications and swifter convalescence although without any benefits in terms of long-term oncological results and quality of life...
August 2014: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Gaya Spolverato, Yuhree Kim, Aslam Ejaz, Vicente Valero, Malcolm H Squires, George Poultsides, Ryan C Fields, Mark Bloomston, Sharon M Weber, Alexandra W Acher, Konstantinos Votanopoulos, Carl Schmidt, Clifford S Cho, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: Surgical experience with minimally invasive surgery (MIS) has increased; however, published reports on MIS resection of gastric adenocarcinoma are limited. METHODS: Between 2000 and 2012, 880 patients who underwent surgical resection of gastric adenocarcinoma were identified from a multi-institutional database. Clinicopathological characteristics, operative details, and outcomes were stratified by operative approach (open vs. MIS) and analyzed. RESULTS: Overall, 70 (8 %) patients had a MIS approach...
September 2014: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
In Gyu Kwon, In Cho, Ali Guner, Yoon Young Choi, Hyun Beak Shin, Hyoung-Il Kim, Ji Yeong An, Jae-Ho Cheong, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: Completion total gastrectomy for remnant gastric cancer (RGC) is technically challenging, especially using the minimally invasive approach. Only a few small case series have reported the technical feasibility of completion total gastrectomy by minimally invasive surgery (MIS). The aim of this study was to compare the efficacy and safety of MIS and open surgery for RGC. METHODS: We retrospectively analyzed 76 completion total gastrectomies for RGC between 2005 and 2012...
August 2014: Surgical Endoscopy
Sébastien Küry, Céline Garrec, Fabrice Airaud, Flora Breheret, Virginie Guibert, Cécile Frenard, Shuo Jiao, Dominique Bonneau, Pascaline Berthet, Céline Bossard, Olivier Ingster, Estelle Cauchin, Stéphane Bezieau
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer (CRC). METHODS: We screened patients with familial CRC forms as well as patients with sporadic CRCs. In a first time, we analyzed exon 11 of the UNC5C gene in 120 unrelated patients with suspected hereditary CRC, 58 patients with suspected Lynch-associated cancer or polyposis, and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair (MMR)...
January 7, 2014: World Journal of Gastroenterology: WJG
Fan Li, Baohua Liu, Yu Gao, Yuliang Liu, Yu Xu, Weidong Tong, Anping Zhang
MicroRNA-107 (miR-107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR-107 was increased in gastric cancer in comparison with the adjacent normal tissues. The enforced expression of miR-107 was able to promote cell proliferation in NCI-N87 and AGS cells, while miR-107 antisense oligonucleotides (antisense miR-107) blocked cell proliferation...
February 14, 2014: FEBS Letters
Seung-Young Oh, Sebastianus Kwon, Kyung-Goo Lee, Yun-Suhk Suh, Hwi-Nyeong Choe, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
BACKGROUND: This study aimed to compare the short- and long-term results of minimally invasive surgery (MIS) and open surgery for primary early gastric cancer (EGC) at a single high-volume institution. METHODS: The clinicopathologic and survival data of primary gastric cancer patients who underwent a minimally invasive radical gastrectomy at Seoul National University Hospital from December 2003 to January 2012 were retrospectively analyzed. For comparison of short-term outcomes, the data for 1,112 patients who underwent a radical open gastrectomy from 2007 to 2011 were collected...
March 2014: Surgical Endoscopy
Dan Huang, Ning Lu, Qinhe Fan, Weiqi Sheng, Hong Bu, Xiaolong Jin, Guimei Li, Yanhui Liu, Xianghong Li, Wenyong Sun, Huizhong Zhang, Xiaobing Li, Zongguang Zhou, Min Yan, Xuan Wang, Weihong Sha, Jiafu Ji, Xiangdong Cheng, Zhiwei Zhou, Jianming Xu, Xiang Du
Trastuzumab has been approved for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction cancers (GC and GJC) in combination with chemotherapy. The aim of this HER2 early/advanced gastric epidemiology (HER-EAGLE) study was to evaluate the frequency of HER2 over-expression and to evaluate agreement on HER2 status assessment in GC and GJC patients in local laboratories versus a central laboratory in China. Tumor samples from 734 GC or GJC patients who were enrolled at 11 different hospitals in China were examined...
2013: PloS One
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