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https://www.readbyqxmd.com/read/27647187/-fast-track-and-minimally-invasive-surgery-for-gastric-cancer
#1
Xin-Xin Liu, Hua-Feng Pan, Zhi-Wei Jiang, Shu Zhang, Zhi-Ming Wang, Ping Chen, Yan Zhao, Gang Wang, Kun Zhao, Jie-Shou Li
BACKGROUND: Enhanced recovery after surgery (ERAS) protocols or fast-track (FT) programs enable a shorter hospital stay and lower complication rate. Minimally invasive surgery (MIS) is associated with a lesser trauma and a quicker recovery in many elective abdominal surgeries. However, little is known of the safety and effectiveness made by ERAS protocols combined with MIS for gastric cancer. The purpose of this study was to evaluate the safety and effectiveness made by FT programs and MIS in combination or alone...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27247553/ca19-9-serum-levels-predict-micrometastases-in-patients-with-gastric-cancer
#2
Tomaz Jagric, Stojan Potrc, Katarina Mis, Mojca Plankl, Tomaz Mars
BACKGROUND: We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. PATIENTS AND METHODS: Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases...
June 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27217695/minimally-invasive-surgery-for-upper-gastrointestinal-cancer-our-experience-and-review-of-the-literature
#3
REVIEW
Koichi Suda, Masaya Nakauchi, Kazuki Inaba, Yoshinori Ishida, Ichiro Uyama
Minimally invasive surgery (MIS) for upper gastrointestinal (GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes...
May 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25631106/robotic-distal-subtotal-gastrectomy-with-d2-lymphadenectomy-for-gastric-cancer-patients-with-high-body-mass-index-comparison-with-conventional-laparoscopic-distal-subtotal-gastrectomy-with-d2-lymphadenectomy
#4
COMPARATIVE STUDY
Juhan Lee, Yoo-Min Kim, Yanghee Woo, Kazutaka Obama, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: Minimally invasive surgery (MIS) has emerged as a treatment of choice for early-stage gastric cancer. However, applying MIS to gastric patients with high body mass index (BMI) is technically challenging, especially when performing D2 lymphadenectomy. Recently, robotic systems have been adopted to overcome the technical limitations of conventional laparoscopic surgery. Nevertheless, studies on the impact of the use of robotic systems to perform D2 lymphadenectomy in high BMI patients are lacking...
November 2015: Surgical Endoscopy
https://www.readbyqxmd.com/read/25480603/minimally-invasive-surgery-as-a-treatment-option-for-gastric-cancer-in-the-elderly-comparison-with-open-surgery-for-patients-80-years-and-older
#5
COMPARATIVE STUDY
In Gyu Kwon, In Cho, Ali Guner, Hyoung-il Kim, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: As life expectancy is increasing, the use of minimally invasive surgery (MIS) in the elderly is gaining interest. The aim of this study was to identify the impact of minimally invasive gastrectomy by comparing the procedure to open surgery in octogenarians. In addition, we also evaluated the role of gastrectomy in elderly gastric cancer patients by assessing long-term outcomes. METHODS: We retrospectively analyzed data from 99 gastric cancer patients aged 80 years or older, who underwent gastrectomy by either MIS or open surgery from 2005 to 2010...
August 2015: Surgical Endoscopy
https://www.readbyqxmd.com/read/25052815/-spectrum-of-laparoscopic-surgery-for-gastric-tumors
#6
REVIEW
S P Mönig, S H Chon, J Weindelmayer, G de Manzoni, A H Hölscher
Minimally invasive operative procedures are increasingly being used for treating tumors of the upper gastrointestinal tract. While minimally invasive surgery (MIS) has become established as a standard procedure for benign tumors and gastrointestinal stromal tumors (GIST) based on current studies, the significance of MIS in the field of gastric cancer is the topic of heated debate. Until now the majority of studies and meta-analyses on gastric cancer have come from Asia and these indicate the advantages of MIS in terms of intraoperative blood loss, minor surgical complications and swifter convalescence although without any benefits in terms of long-term oncological results and quality of life...
August 2014: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/24912915/a-multi-institutional-analysis-of-open-versus-minimally-invasive-surgery-for-gastric-adenocarcinoma-results-of-the-us-gastric-cancer-collaborative
#7
MULTICENTER STUDY
Gaya Spolverato, Yuhree Kim, Aslam Ejaz, Vicente Valero, Malcolm H Squires, George Poultsides, Ryan C Fields, Mark Bloomston, Sharon M Weber, Alexandra W Acher, Konstantinos Votanopoulos, Carl Schmidt, Clifford S Cho, Shishir K Maithel, Timothy M Pawlik
BACKGROUND: Surgical experience with minimally invasive surgery (MIS) has increased; however, published reports on MIS resection of gastric adenocarcinoma are limited. METHODS: Between 2000 and 2012, 880 patients who underwent surgical resection of gastric adenocarcinoma were identified from a multi-institutional database. Clinicopathological characteristics, operative details, and outcomes were stratified by operative approach (open vs. MIS) and analyzed. RESULTS: Overall, 70 (8 %) patients had a MIS approach...
September 2014: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/24622766/minimally-invasive-surgery-for-remnant-gastric-cancer-a-comparison-with-open-surgery
#8
COMPARATIVE STUDY
In Gyu Kwon, In Cho, Ali Guner, Yoon Young Choi, Hyun Beak Shin, Hyoung-Il Kim, Ji Yeong An, Jae-Ho Cheong, Sung Hoon Noh, Woo Jin Hyung
BACKGROUND: Completion total gastrectomy for remnant gastric cancer (RGC) is technically challenging, especially using the minimally invasive approach. Only a few small case series have reported the technical feasibility of completion total gastrectomy by minimally invasive surgery (MIS). The aim of this study was to compare the efficacy and safety of MIS and open surgery for RGC. METHODS: We retrospectively analyzed 76 completion total gastrectomies for RGC between 2005 and 2012...
August 2014: Surgical Endoscopy
https://www.readbyqxmd.com/read/24415873/evaluation-of-the-colorectal-cancer-risk-conferred-by-rare-unc5c-alleles
#9
Sébastien Küry, Céline Garrec, Fabrice Airaud, Flora Breheret, Virginie Guibert, Cécile Frenard, Shuo Jiao, Dominique Bonneau, Pascaline Berthet, Céline Bossard, Olivier Ingster, Estelle Cauchin, Stéphane Bezieau
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer (CRC). METHODS: We screened patients with familial CRC forms as well as patients with sporadic CRCs. In a first time, we analyzed exon 11 of the UNC5C gene in 120 unrelated patients with suspected hereditary CRC, 58 patients with suspected Lynch-associated cancer or polyposis, and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair (MMR)...
January 7, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24374340/upregulation-of-microrna-107-induces-proliferation-in-human-gastric-cancer-cells-by-targeting-the-transcription-factor-foxo1
#10
Fan Li, Baohua Liu, Yu Gao, Yuliang Liu, Yu Xu, Weidong Tong, Anping Zhang
MicroRNA-107 (miR-107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR-107 was increased in gastric cancer in comparison with the adjacent normal tissues. The enforced expression of miR-107 was able to promote cell proliferation in NCI-N87 and AGS cells, while miR-107 antisense oligonucleotides (antisense miR-107) blocked cell proliferation...
February 14, 2014: FEBS Letters
https://www.readbyqxmd.com/read/24263458/outcomes-of-minimally-invasive-surgery-for-early-gastric-cancer-are-comparable-with-those-for-open-surgery-analysis-of-1-013-minimally-invasive-surgeries-at-a-single-institution
#11
COMPARATIVE STUDY
Seung-Young Oh, Sebastianus Kwon, Kyung-Goo Lee, Yun-Suhk Suh, Hwi-Nyeong Choe, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
BACKGROUND: This study aimed to compare the short- and long-term results of minimally invasive surgery (MIS) and open surgery for primary early gastric cancer (EGC) at a single high-volume institution. METHODS: The clinicopathologic and survival data of primary gastric cancer patients who underwent a minimally invasive radical gastrectomy at Seoul National University Hospital from December 2003 to January 2012 were retrospectively analyzed. For comparison of short-term outcomes, the data for 1,112 patients who underwent a radical open gastrectomy from 2007 to 2011 were collected...
March 2014: Surgical Endoscopy
https://www.readbyqxmd.com/read/24244671/her2-status-in-gastric-and-gastroesophageal-junction-cancer-assessed-by-local-and-central-laboratories-chinese-results-of-the-her-eagle-study
#12
MULTICENTER STUDY
Dan Huang, Ning Lu, Qinhe Fan, Weiqi Sheng, Hong Bu, Xiaolong Jin, Guimei Li, Yanhui Liu, Xianghong Li, Wenyong Sun, Huizhong Zhang, Xiaobing Li, Zongguang Zhou, Min Yan, Xuan Wang, Weihong Sha, Jiafu Ji, Xiangdong Cheng, Zhiwei Zhou, Jianming Xu, Xiang Du
Trastuzumab has been approved for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction cancers (GC and GJC) in combination with chemotherapy. The aim of this HER2 early/advanced gastric epidemiology (HER-EAGLE) study was to evaluate the frequency of HER2 over-expression and to evaluate agreement on HER2 status assessment in GC and GJC patients in local laboratories versus a central laboratory in China. Tumor samples from 734 GC or GJC patients who were enrolled at 11 different hospitals in China were examined...
2013: PloS One
https://www.readbyqxmd.com/read/24149848/minimally-invasive-surgery-for-serosa-positive-gastric-cancer-pt4a-in-patients-with-preoperative-diagnosis-of-cancer-without-serosal-invasion
#13
T Son, W J Hyung, J H Lee, Y M Kim, S H Noh
BACKGROUND: Although surgeons normally use minimally invasive surgery (MIS) for patients with early gastric cancer, in Korea and Japan the procedure is also indicated for serosa-negative tumors. Serosal invasion is regarded to be a potential risk factor for peritoneal dissemination as a result of the effect of pneumoperitoneum and tumor manipulation during the operation. We compared operative outcomes between MIS and conventional open surgery for serosa-involved advanced gastric cancer patients who had a preoperative diagnosis of cancer without serosal invasion...
March 2014: Surgical Endoscopy
https://www.readbyqxmd.com/read/23508453/down-regulation-of-mir-302b-an-esc-specific-microrna-in-gastric-adenocarcinoma
#14
Mitra Khalili, Majid Sadeghizadeh, Kamran Ghorbanian, Reza Malekzadeh, Mohammad Vasei, Seyed Javad Mowla
OBJECTIVE: microRNAs (miRNAs) are a new class of non-coding RNAs involved in regulating various biological processes including proliferation, differentiation, and apoptosis, among others. Alterations in miRNA expression are reported in several human cancers, which suggests their potential roles in tumor initiation and progression. Members of the miR-302 cluster are highly expressed in embryonic stem cells (ESC), where they regulate cell self-renewal and pluripotency. Based on the cancer stem cell (CSC) hypothesis, mis-expression of such genes might contribute to tumorigenicity...
2012: Cell Journal
https://www.readbyqxmd.com/read/23340279/evaluation-of-a-focused-sentinel-lymph-node-protocol-in-node-negative-gastric-cancer-patients
#15
T Jagric, A Ivanecz, M Horvat, M Plankl, R Kavalar, S Kavalar, K Mis, T Mars
BACKGROUND/AIMS: A specific preoperative work-up was used to access a limited number of high-risk lymph nodes with RT-qPCR for micrometastatic sentinel lymph node involvement. We validated our protocol with IHC screening for micrometastases and long-term survival analysis. METHODOLOGY: From the 32 patients included 22 were node-negative patients. With a specific preoperative protocol sentinel lymph nodes (1-2 per patient) were extracted for further RT-qPCR analysis for CEA and CK20 expression...
July 2013: Hepato-gastroenterology
https://www.readbyqxmd.com/read/22906247/trends-and-outcomes-of-minimally-invasive-surgery-for-gastric-cancer-750-consecutive-cases-in-seven-years-at-a-single-center
#16
Hoon Hur, Yi Xuan, Chang Wook Ahn, Yong Kwan Cho, Sang-Uk Han
BACKGROUND: The aims of this study were to investigate trends in minimally invasive surgery (MIS) for gastric cancer through the experience of a single center and to predict the direction of the development of MIS. METHODS: During a 7-year period, 2,160 patients underwent curative gastric cancer surgery. Changes in the proportion and pathologic features of a total of 750 cases that involved MIS, as well as the surgical methods and outcomes of MIS, were analyzed...
January 2013: American Journal of Surgery
https://www.readbyqxmd.com/read/22090020/-minimally-invasive-gastric-surgery
#17
REVIEW
K Ludwig, U Scharlau, S Schneider-Koriath, J Bernhardt
The interest in minimally invasive surgery (MIS) for the treatment of gastric carcinoma has increased in recent years worldwide. In particular, for early gastric carcinoma (EGC) many retrospective comparative trials and some prospective randomized trials have confirmed that laparoscopy-assisted distal gastrectomy shows a better short-term outcome in terms of lower morbidity, less pain, faster recovery and shorter hospital stay in contrast to open surgery. In this group of selected patients MIS is safe and feasible but at present not widely accepted because of a limited evaluation in oncologic long-term follow-up...
January 2012: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/22066116/the-current-status-and-future-perspectives-of-laparoscopic-surgery-for-gastric-cancer
#18
Hyung-Ho Kim, Sang-Hoon Ahn
Gastric cancer is most common cancer in Korea. Surgery is still the main axis of treatment. Due to early detection of gastric cancer, the innovation of surgical instruments and technological advances, gastric cancer treatment is now shifting to a new era. One of the most astonishing changes is that minimally invasive surgery (MIS) is becoming more dominant treatment for early gastric cancer. These MIS are represented by endoscopic resection, laparoscopic surgery, robotic surgery, single-port surgery and natural orifice transluminal endoscopic surgery...
September 2011: Journal of the Korean Surgical Society
https://www.readbyqxmd.com/read/21476116/minimally-invasive-surgery-for-gastric-cancer-the-future-standard-of-care
#19
REVIEW
Keisuke Koeda, Satoshi Nishizuka, Go Wakabayashi
Laparoscopy-assisted distal gastrectomy for gastric cancer was first reported by Kitano et al. in 1991. Laparoscopic wedge resection (LWR) and intragastric mucosal resection (IGMR) were quickly adapted for gastric cancer limited to the mucosal layer and having no risk of lymph node metastasis. Following improvements in endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), the use of LWR and IGMR for these indications decreased, and patients with gastric cancer, including those with a risk of lymph node metastases, were more likely to be managed with laparoscopic gastrectomy (LG) with lymph node dissection...
July 2011: World Journal of Surgery
https://www.readbyqxmd.com/read/20414682/subtotal-gastrectomy-with-d2-dissection-by-minimally-invasive-surgery-for-distal-adenocarcinoma-of-the-stomach-results-and-5-year-survival
#20
Raffaele Pugliese, Dario Maggioni, Fabio Sansonna, Andrea Costanzi, Giovanni Carlo Ferrari, Stefano Di Lernia, Carmelo Magistro, Paolo De Martini, Francesco Pugliese
BACKGROUND: The purpose of this study is to assess outcomes and 5-year survival after subtotal gastrectomy (SG) for early and advanced distal adenocarcinoma with D2 dissection performed by minimally invasive surgery (MIS). METHODS: From June 2000 to October 2009 a total of 70 patients with adenocarcinoma of the lower third of the stomach underwent SG with D2 nodal clearance by MIS. This series enrolled 37 patients with early gastric cancer (EGC) and 33 with advanced gastric cancer (AGC)...
October 2010: Surgical Endoscopy
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