Bita Taghizadeh, Reza Moradi, Bashir Sobhani, Hamid Mohammadpanah, Saeed Behboodifar, Shiva Golmohammadzadeh, Jamshidkhan Chamani, Masoud Maleki, Effat Alizadeh, Nosratollah Zarghami, Mahmoud Reza Jaafari
Due to its involvement in skin maintenance and repair, topical administration of recombinant human growth hormone (rhGH) is an interesting strategy for therapeutic purposes. We have formulated and characterized a topical rhGH-loaded liposomal formulation (rhGH-Lip) and evaluated its safety, biological activity, and preventive role against UVB-induced skin damage. The rhGH-Lip had an average size and zeta potential of 63 nm and -33 mV, respectively, with 70 % encapsulation efficiency. The formulation was stable at 4 °C for at least one year...
March 7, 2024: International Journal of Biological Macromolecules