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https://www.readbyqxmd.com/read/28427235/catan-ionic-hybrid-lipidic-nano-carriers-for-enhanced-bioavailability-and-anti-tumor-efficacy-of-chemodrugs
#1
Bilin Liu, Dan He, Jianyong Wu, Quan Sun, Mi Zhang, Qunyou Tan, Yao Li, Jingqing Zhang
To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carriers containing curcumin (CUR-C-HLN) inherit the merits of catan-ionic systems, hybrid lipidic systems and nano-structured carriers (the second-generation substitute of solid lipidic nano-systems). Catan-ionic surfactants increased microvesicle stabilization by producing unordered isometric clusters, enhanced absorptive amount as an inhibitor of enzyme and protein, improved tumor accumulation by cellular endocytosis and membranous fusion; hybrid lipids helped to obtain high drug content and low leakage by forming a less-organized matrix arrangement...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417088/boiling-induced-nanoparticles-and-their-constitutive-proteins-from-isatis-indigotica-fort-root-decoction-purification-and-identification
#2
Jianwu Zhou, Jie Liu, Dai Lin, Guanzhen Gao, Huiqin Wang, Jingke Guo, Pingfan Rao, Lijing Ke
Colloidal particles are essential components of sun-dried Isatis indigotica Fort. roots (Ban-Lan-Gen in Chinese, BLG) decoction. Nanoparticles (NPs) were isolated from BLG decoction with size exclusion chromatography and characterized. Their average diameter is ∼120 nm, reversibly responding to pH and temperature changes. They promoted the growth of normal cells but suppressed that of cancerogenic cells and macrophages. Two constitutive glycated proteins were identified from the NPs, namely BLGP1 and BLGP2...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28383528/the-effect-of-the-serum-corona-on-interactions-between-a-single-nano-object-and-a-living-cell
#3
Yael Dror, Raya Sorkin, Guy Brand, Olga Boubriak, Jill Urban, Jacob Klein
Nanoparticles (NPs) which enter physiological fluids are rapidly coated by proteins, forming a so-called corona which may strongly modify their interaction with tissues and cells relative to the bare NPs. In this work the interactions between a living cell and a nano-object, and in particular the effect on this of the adsorption of serum proteins, are directly examined by measuring the forces arising as an Atomic Force Microscope tip (diameter 20 nm) - simulating a nano-object - approaches and contacts a cell...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377276/encapsulation-systems-for-the-delivery-of-hydrophilic-nutraceuticals-food-application
#4
REVIEW
N P Aditya, Yadira Gonzalez Espinosa, Ian T Norton
Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers...
April 1, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28371407/biocatalytic-virus-capsid-as-nanovehicle-for-enzymatic-activation-of-tamoxifen-in-tumor-cells
#5
Alejandro Tapia-Moreno, Karla Juarez-Moreno, Oscar Gonzalez-Davis, Ruben D Cadena-Nava, Rafael Vazquez-Duhalt
Most of the drugs used in chemotherapy should be activated by a transformation catalyzed by cytochrome P450 (CYP) enzymes. In this work, bacteriophage P22 virus-like particles (VLPs) containing CYP activity, immunologically inert and functionalized in order to be recognized by human cervix carcinoma cells and human breast adenocarcinoma cells were designed. The CYP was encapsulated inside the virus capsid obtained from the bacteriophage P22. CYP and coat protein were both heterologously expressed in E. coli...
April 3, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28352880/nano-thin-walled-micro-compartments-from-transmembrane-protein-polymer-conjugates
#6
Himanshu Charan, Ulrich Glebe, Deepak Anand, Julia Kinzel, Leilei Zhu, Marco Bocola, Tayebeh Mirzaei Garakani, Ulrich Schwaneberg, Alexander Böker
The high interfacial activity of protein-polymer conjugates has inspired their use as stabilizers for Pickering emulsions, resulting in many interesting applications such as synthesis of templated micro-compartments and protocells or vehicles for drug and gene delivery. In this study we report, for the first time, the stabilization of Pickering emulsions with conjugates of a genetically modified transmembrane protein, ferric hydroxamate uptake protein component A (FhuA). The lysine residues of FhuA with open pore (FhuA ΔCVF(tev)) were modified to attach an initiator and consequently controlled radical polymerization (CRP) carried out via the grafting-from technique...
April 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28352171/the-influence-of-surface-charge-on-serum-protein-interaction-and-cellular-uptake-studies-with-dendritic-polyglycerols-and-dendritic-polyglycerol-coated-gold-nanoparticles
#7
Tony Bewersdorff, Jonathan Vonnemann, Asiye Kanik, Rainer Haag, Andrea Haase
Nanoparticles (NPs) have gained huge interest in the medical field, in particular for drug delivery purposes. However, binding of proteins often leads to fast NP uptake and rapid clearance, thereby hampering medical applications. Thus, it is essential to determine and control the bio-nano interface. This study investigated the serum protein interactions of dendritic polyglycerols (dPGs), which are promising drug delivery candidates by means of two dimensional gel electrophoresis (2DE) in combination with mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28343017/%C3%AE-lactoglobulin-an-efficient-nanocarrier-for-advanced-delivery-systems
#8
REVIEW
Zahra Shafaei, Behafarid Ghalandari, Akbar Vaseghi, Adeleh Divsalar, Thomas Haertlé, Ali Akbar Saboury, Lindsay Sawyer
Thanks to the progress of nanotechnology there are several agent-delivery systems that can be selected to achieve rapid and specific delivery of a wide variety of biologically active agents. Consequently, the manipulation and engineering of biopolymers has become one of the most exciting subjects for those who study delivery systems on the nanoscale. In this regard, both nanoparticle formation and a carrier role have been observed in the case of the globular milk whey protein, β-lactoglobulin (β-LG), setting it apart from many other proteins...
March 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28323095/megalin-targeted-enhanced-transfection-efficiency-in-cultured-human-hk-2-renal-tubular-proximal-cells-using-aminoglycoside-carboxyalkyl-polyethylenimine-containing-nanoplexes
#9
Fatemeh Oroojalian, Ali Hossein Rezayan, Wayne Thomas Shier, Khalil Abnous, Mohammad Ramezani
Non-viral vectors are of interest as therapeutic gene delivery agents in gene therapy, because they are simple to prepare, easy to modify and have definable safety profiles compared to viral vectors. The potential of gene therapy in the treatment of renal diseases is limited by a lack of effective kidney-targeted gene delivery systems. Aminoglycoside antibiotics gentamicin and neomycin were connected by amide linkages to carboxyl groups on carboxyalkylated-PEI25 (25kDa PEI) or carboxyalkylated-PEI10 (10kDa PEI)...
March 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28276530/overcoming-sorafenib-evasion-in-hepatocellular-carcinoma-using-cxcr4-targeted-nanoparticles-to-co-deliver-mek-inhibitors
#10
Yunching Chen, Ya-Chi Liu, Yun-Chieh Sung, Rakesh R Ramjiawan, Ts-Ting Lin, Chih-Chun Chang, Kuo-Shyang Jeng, Chiung-Fang Chang, Chun-Hung Liu, Dong-Yu Gao, Fu-Fei Hsu, Annique M Duyverman, Shuji Kitahara, Peigen Huang, Simona Dima, Irinel Popescu, Keith T Flaherty, Andrew X Zhu, Nabeel Bardeesy, Rakesh K Jain, Cyril H Benes, Dan G Duda
Sorafenib is a RAF inhibitor approved for several cancers, including hepatocellular carcinoma (HCC). Inhibition of RAF kinases can induce a dose-dependent "paradoxical" upregulation of the downstream mitogen-activated protein kinase (MAPK) pathway in cancer cells. It is unknown whether "paradoxical" ERK activation occurs after sorafenib therapy in HCC, and if so, if it impacts the therapeutic efficacy. Here, we demonstrate that RAF inhibition by sorafenib rapidly leads to RAF dimerization and ERK activation in HCCs, which contributes to treatment evasion...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275313/zinc-oxide-tetrapods-inhibit-herpes-simplex-virus-infection-of-cultured-corneas
#11
Neil Duggal, Dinesh Jaishankar, Tejabhiram Yadavalli, Satvik Hadigal, Yogendra Kumar Mishra, Rainer Adelung, Deepak Shukla
PURPOSE: Infection of the human cornea by herpes simplex virus type-1 (HSV-1) can cause significant vision loss. The purpose of this study was to develop an ex vivo model to visualize viral growth and spread in the cornea. The model was also used to analyze cytokine production and study the antiviral effects of zinc oxide tetrapods. METHODS: A β-galactosidase-expressing recombinant virus, HSV-1(KOS)tk12, was used to demonstrate the ability of the virus to enter and develop blue plaques on human corneal epithelial (HCE) cells and corneal tissues...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28249594/enhancement-of-scutellarin-oral-delivery-efficacy-by-vitamin-b12-modified-amphiphilic-chitosan-derivatives-to-treat-type-ii-diabetes-induced-retinopathy
#12
Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-Ming Zhang, Banghao Zhu, Liqun Yang, David Y B Deng
BACKGROUND: Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular endothelial cell dysfunction. However, its clinical applications have been limited by its low bioavailability. In this study, we formulated and characterized a novel intestinal target nanoparticle carrier based on amphiphilic chitosan derivatives (Chit-DC-VB12) loaded with scutellarin to enhance its bioavailability and then evaluated its therapeutic effect in experimental diabetic retinopathy model...
March 1, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28249113/fabrication-of-a-soybean-bowman-birk-inhibitor-bbi-nanodelivery-carrier-to-improve-bioavailability-of-curcumin
#13
Chun Liu, Fenfen Cheng, Xiaoquan Yang
Curcumin is a poorly water-soluble drug, and its oral bioavailability is very low. Here, a novel self-assembly nanoparticle delivery carrier has been successfully developed by using soybean Bowman-Birk inhibitor (BBI) to improve the solubility, bioaccessibility, and oral absorption of curcumin. BBI is a unique protein, which can be resistant to the pH range and proteolytic enzymes in the gastrointestinal tract (GIT), bioavailable, and not allergenic. The encapsulation efficiencies (EE) and the loading capacities (LC) of curcumin in the curcumin-loaded BBI nanoparticles (Cur-BBI-NPs, size = 90...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28248524/biocompatible-soft-nanoparticles-with-multiple-morphologies-obtained-from-nanoprecipitation-of-amphiphilic-graft-copolymers-in-a-backbone-selective-solvent
#14
Gaëlle Le Fer, Clémence Le Cœur, Jean-Michel Guigner, Catherine Amiel, Gisèle Volet
Stealth nanocarriers are a promising technology for the treatment of diseases. However, the preparation and characterization of well-defined soft nanoparticulate systems remain challenging. Here we describe a platform of amphiphilic graft copolymers leading to nanoparticles with multiple morphologies and the role of the hydrophilic backbone in their interaction with a model protein. The amphiphilic graft copolymers platform was composed of hydrophilic backbone poly(2-methyl-2-oxazoline-co-2-pentyl-2-oxazoline) (P(MeOx-co-PentOx)), prepared via cationic ring-opening polymerization...
March 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28244542/probing-the-structural-basis-and-adsorption-mechanism-of-an-enzyme-on-nano-sized-protein-carriers
#15
Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Michael Bridges, James Froberg, Jiajia Rao, Steven Y Qian, Guodong Liu, Yongki Choi, Zhongyu Yang
Silica nanoparticles (SiNPs) are important nano-sized, solid-state carriers/hosts to load, store, and deliver biological or pharmaceutical cargoes. They are also good potential solid supports to immobilize proteins for fundamental protein structure and dynamics studies. However, precaution is necessary when using SiNPs in these areas because adsorption might alter the activity of the cargoes, especially when enzymes are loaded. Therefore, it becomes important to understand the structural basis of the cargo enzyme activity changes, if there is any...
February 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28243085/continuous-release-of-bone-morphogenetic-protein-2-through-nano-graphene-oxide-based-delivery-influences-the-activation-of-the-nf-%C3%AE%C2%BAb-signal-transduction-pathway
#16
Cheng Zhong, Jun Feng, Xiangjin Lin, Qi Bao
Graphene oxide (GO) has been used as a delivery vehicle for small molecule drugs and nucleotides. To further investigate GO as a smart biomaterial for the controlled release of cargo molecules, we hypothesized that GO may be an appropriate delivery vehicle because it releases bone morphogenetic protein 2 (BMP2). GO characterization indicated that the size distribution of the GO flakes ranged from 81.1 nm to 45,749.7 nm, with an approximate thickness of 2 nm. After BMP2 adsorption onto GO, Fourier-transformed infrared spectroscopy (FTIR) and thermal gravimetric analysis were performed...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28238134/evaluating-nanoparticle-binding-to-blood-compartment-immune-cells-in-high-throughput-with-flow-cytometry
#17
Shann S Yu
Nanoparticles are increasingly being utilized for in vivo applications, where they are implemented as carriers for drugs, contrast agents for noninvasive medical imaging, or delivery vehicles for macromolecular agents such as DNA or proteins. However, they possess many physical and chemical properties that cause them to become rapidly recognized by the immune system as a foreign body, leading to their clearance and elimination, even before they may accumulate to critical concentrations at anatomic and cellular sites of action...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28237436/cationic-dendritic-starch-as-a-vehicle-for-photodynamic-therapy-and-sirna-co-delivery
#18
Sarah A Engelberth, Nadine Hempel, Magnus Bergkvist
Cationic enzymatically synthesized glycogen (cESG) is a naturally-derived, nano-scale carbohydrate dendrite that has shown promise as a cellular delivery vehicle owing to its flexibility in chemical modifications, biocompatibility and relative low cost. In the present work, cESG was modified and evaluated as a vehicle for tetraphenylporphinesulfonate (TPPS) in order to improve cellular delivery of this photosensitizer and investigate the feasibility of co-delivery with short interfering ribonucleic acid (siRNA)...
March 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28228075/challenges-in-dermal-delivery-of-therapeutic-antimicrobial-protein-and-peptides
#19
Rohan Aminbhai Lalani, Ambikanandan Misra, Jitendra Amrutiya, Hinal Patel, Priyanka Bhatt, Vivek Patel
BACKGROUND: Protein and peptides in biological system form an important part of innate immune system and are being explored for potential use in various diseases as therapeutics. Importance of proteins and peptides as a new class of antimicrobial agents have boosted research in the field of biotechnology as potential alternative to antibiotic agents. OBJECTIVE: Protein and peptides antimicrobial as a therapeutics class are structurally diverse and exhibit potent activity against microbes by various mechanisms...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28215090/nonviral-genome-editing-based-on-a-polymer-derivatized-crispr-nanocomplex-for-targeting-bacterial-pathogens-and-antibiotic-resistance
#20
Yoo Kyung Kang, Kyu Kwon, Jea Sung Ryu, Ha Neul Lee, Chankyu Park, Hyun Jung Chung
The overuse of antibiotics plays a major role in the emergence and spread of multidrug-resistant bacteria. A molecularly targeted, specific treatment method for bacterial pathogens can prevent this problem by reducing the selective pressure during microbial growth. Herein, we introduce a nonviral treatment strategy delivering genome editing material for targeting antibacterial resistance. We apply the CRISPR-Cas9 system, which has been recognized as an innovative tool for highly specific and efficient genome engineering in different organisms, as the delivery cargo...
February 27, 2017: Bioconjugate Chemistry
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