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protein nano-delivery

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https://www.readbyqxmd.com/read/28809092/particle-targeting-in-complex-biological-media
#1
REVIEW
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Björnmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e...
August 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#2
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28755992/microgels-of-silylated-hpmc-as-a-multimodal-system-for-drug-co-encapsulation
#3
Mohamed Zayed, Corine Tourne-Peteilh, Michel Ramonda, Gildas Rethore, Pierre Weiss, Jean Martinez, Gilles Subra, Ahmad Mehdi, Jean-Marie Devoisselle, Philippe Legrand
Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles. Silylated hydrogels are alkoxysilane hybrid polymers that can be engaged in a sol-gel process, providing chemical cross linking in physiological conditions, and functionalized biocompatible hybrid materials. In the present work, microgels were prepared with silylated (hydroxypropyl)methyl cellulose (Si-HPMC) that was chemically cross linked in soft conditions of pH and temperature...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28754647/biomimetically-grown-apatite-spheres-from-aggregated-bioglass-nanoparticles-with-ultrahigh-porosity-and-surface-area-imply-potential-drug-delivery-and-cell-engineering-applications
#4
Ahmed El-Fiqi, Jennifer O Buitrago, Sung Hee Yang, Hae-Won Kim
Here we communicate the generation of biomimetically grown apatite spheres from aggregated bioglass nanoparticles and the potential properties applicable for drug delivery and cell/tissue engineering. Ion releasing nanoparticulates of bioglass (85%SiO2-15%CaO) in a mineralizing medium show an intriguing dynamic phenomenon - aggregation, mineralization to apatite, integration and growth into micron-sized (1.5-3μm) spheres. During the progressive ionic dissolution/precipitation reactions, nano-to-micro-morphology, glass-to-crystal composition, and the physico-chemical properties (porosity, surface area, and charge) change dynamically...
July 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712299/evaluation-of-efficacy-and-toxicity-of-exfoliated-silicate-nanoclays-as-a-feed-additive-for-fumonisin-detoxification
#5
Chiao-Wei Yuan, Jie-Ting Huang, Ching-Chin Chen, Pin-Chi Tang, Jenn-Wen Huang, Jiang-Jen Lin, San-Yuan Huang, Shuen-Ei Chen
The efficacy of nanosilicate clay platelets (NSCP), exfoliated silicates from natural montmorillonites, as a feed additive for ameliorating fumonisin B1 (FB1) toxicosis was evaluated. Toxicological mechanisms by NSCP were examined through proteomic and biochemical analyses. Dietary supplementation with NSCP at a low level of 40 mg/kg of feed improved growth performances in chickens with respect to FB1 toxicosis. Other issues of ameliorated symptoms including serum and/or hepatic aspartate aminotransferase activity, oxidative stress indicators, and sphinganine/sphingosine ratio, a hallmark of FB1 toxicosis, were considered...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28707627/mussel-inspired-nano-building-block-assemblies-for-mimicking-extracellular-matrix-microenvironments-with-multiple-functions
#6
Zhenming Wang, Zhanrong Jia, Yanan Jiang, Pengfei Li, Lu Han, Xiong Lu, Fuzeng Ren, Ke-Feng Wang, Huipin Yuan
The assembly of nano-building blocks is an effective way to produce artificial extracellular matrix microenvironments with hierarchical micro/nano structures. However, it is hard to assemble different types of nano-building blocks, to form composite coatings with multiple functions, by traditional layer-by-layer (LbL) self-assembly methods. Inspired by the mussel adhesion mechanism, we developed polydopamine (PDA)-decorated bovine serum albumin nanoparticles (BSA-NPs) and nano-hydroxyapatite (nano-HA), and assembled them to form bioactive coatings with micro/nano structures encapsulating bone morphogenetic protein-2 (BMP-2)...
July 14, 2017: Biofabrication
https://www.readbyqxmd.com/read/28706754/smart-release-nano-formulation-of-cytochrome-c-and-hyaluronic-acid-induces-apoptosis-in-cancer-cells
#7
C M Figueroa, B N Suárez, A M Molina, J C Fernández, Z Torres, K Griebenow
Herein we tested a nanosized cancer-cell targeted delivery system based on cytochrome c (Cyt c) and hyaluronic acid. Cyt c was chosen since it is a per se non-toxic protein but causes apoptosis when delivered to the cytoplasm of target cells. Hyaluronic acid was employed to create the nanosized delivery system with passive targeting capability in order to exploit the enhanced permeation and retention (EPR) effect and active targeting capability of hyaluronic acid. In addition, our goal was to incorporate a smart release strategy to only promote protein release upon reaching its target...
February 2017: Journal of Nanomedicine & Nanotechnology
https://www.readbyqxmd.com/read/28702661/clinically-approved-pegylated-nanoparticles-are-covered-by-a-protein-corona-that-boosts-the-uptake-by-cancer-cells
#8
M Papi, D Caputo, V Palmieri, R Coppola, S Palchetti, F Bugli, C Martini, L Digiacomo, D Pozzi, G Caracciolo
Today, liposomes are an advanced technology of drug carriers with a dozen drugs in clinical practice and many more in clinical trials. A bottleneck associated with the clinical translation of liposomes has long been 'opsonization', i.e. the adsorption of plasma proteins at the liposome surface resulting in their rapid clearance from circulation. For decades, the most popular way to avoid opsonization has been grafting polyethylene glycol (PEG) onto the liposome surface. Recent studies have clarified that grafting PEG onto the liposome surface reduces, but does not completely prevent protein binding...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28699500/cell-derived-exosomes-as-promising-carriers-for-drug-delivery-and-targeted-therapy
#9
Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying, Yi Ba
Exosomes are small vesicles that are secreted by various types of cells, known to mediate signal transduction between cells. During recent years, novel carriers for the delivery of targeted drugs, chemotherapy drugs and RNAs are under development, which is believed to be beneficial for patients. Considering issues of drug nano-formulations in bloodstream, such as nano-toxicity and rapid clearance by mononuclear phagocyte system, exosomes derived from either patient's cells or bodyfluids, seem to be an optimal option...
July 10, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28693994/ferritin-glycosylated-by-chitosan-as-a-novel-egcg-nano-carrier-structure-stability-and-absorption-analysis
#10
Rui Yang, Yuqian Liu, Yunjing Gao, Yongjin Wang, Chris Blanchard, Zhongkai Zhou
Ferritin is a shell-like carrier protein with an 8nm diameter cavity which endows a natural space to encapsulate food and drug components. In this work, phytoferritin was unprecedentedly glycosylated by chitosan to fabricate ferritin-chitosan Maillard reaction products (FCMPs) (grafting degree of 26.17%, 24h, 55°C). Results indicated that the amide I and II bands of ferritin were altered due to the chitosan grafting, whereas the ferritin spherical structure were retained. Simulated digestion analysis showed that the FCMPs were more resistant to pepsin and trypsin digestion as compared with ferritin alone...
July 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28693954/nano-encapsulation-of-chicken-immunoglobulin-igy-in-sodium-alginate-nanoparticles-in%C3%A2-vitro-characterization
#11
Mostafa Bakhshi, Firouz Ebrahimi, Shahram Nazarian, Jamil Zargan, Faeze Behzadi, Dawood Sadeghi Gariz
Controlled delivery of therapeutic agents by alginate nanoparticles became an attractive issue in the gastric organ. Some therapeutic agents such as proteins could not tolerate in severe condition in the gastrointestinal tract. In the present study, four concentrations of a specific IgY as a prophylactic agent against E. coli O157: H7 was entrapped in 0.2% w/v sodium alginate nanoparticles by ionic gelation method. Depending on the IgY concentration entrapment efficacy was 28.31-99.84%. The physicochemical and structural characteristics of free and IgY-loaded Alg NPs revealed that the individual particles exhibited a spherical shape with a diameter of 45-85 nm, and a negatively charged surface with a zeta potential value of 26-36 mV...
July 7, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28685231/hybrid-polymeric-protein-nano-carriers-hppnc-for-targeted-delivery-of-tgf%C3%AE-inhibitors-to-hepatocellular-carcinoma-cells
#12
Nemany A N Hanafy, Alessandra Quarta, Riccardo Di Corato, Luciana Dini, Concetta Nobile, Vittorianna Tasco, Sonia Carallo, Mariafrancesca Cascione, Andrea Malfettone, Jitka Soukupova, Rosaria Rinaldi, Isabel Fabregat, Stefano Leporatti
TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery is required. Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28672263/functionalizing-soy-protein-nano-aggregates-with-ph-shifting-and-mano-thermo-sonication
#13
Gulcin Yildiz, Juan Andrade, Nicki E Engeseth, Hao Feng
Plant protein-mediated nano-delivery systems have gained increasing attention in the food and pharmaceutical industries in recent years. Several physical and chemical methods for improving the functional properties of plant proteins with respect to the native forms have been proposed. This study presents a new approach, which combines pH-shifting and mano-thermo-sonication (MTS) to produce soy protein nano-aggregates with significantly improved functional properties. Soy-protein isolate (SPI) was treated with pH-shifting at pH 12 or in combination with MTS and high-pressure homogenization (HPH)...
June 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28650030/carbon-nanoscroll-silk-crystallite-hybrid-structures-with-controllable-hydration-and-mechanical-properties
#14
Yuan Cheng, Leng-Duei Koh, Fan Wang, Dechang Li, Baohua Ji, Jingjie Yeo, Guijian Guan, Ming-Yong Han, Yong-Wei Zhang
Hybrid structures of nanomaterials (e.g. tubes, scrolls, threads, cages) and biomaterials (e.g. proteins) hold tremendous potential for applications as drug carriers, biosensors, tissue scaffolds, cancer therapeutic agents, etc. However, in many cases, the interacting forces at the nano-bio interfaces and their roles in controlling the structures and dynamics of nano-bio-hybrid systems are very complicated but poorly understood. In this study, we investigate the structure and mechanical behavior of a protein-based hybrid structure, i...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28641543/zein-based-nanocarriers-as-potential-natural-alternatives-for-drug-and-gene-delivery-focus-on-cancer-therapy
#15
Ahmed Elzoghby, May Freag, Hadeer Mamdouh, Kadria Elkhodairy
Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28640580/a-bioinspired-alginate-gum-arabic-hydrogel-with-micro-nanoscale-structures-for-controlled-drug-release-in-chronic-wound-healing
#16
Mi Li, Haichang Li, Xiangguang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma, Mingjun Zhang
Biopolymeric hydrogels have drawn increasing research interest in biomaterials due to their tunable physical and chemical properties for both creating bioactive cellular microenvironment and serving as sustainable therapeutic reagents. Inspired by a naturally occurring hydrogel secreted from the carnivorous Sundew plant for trapping insects, here we have developed a bioinspired hydrogel to deliver mitsugumin 53 (MG53), an important protein in cell membrane repair, for chronic wound healing. Both chemical compositions and micro-/nanomorphological properties inherent from the natural Sundew hydrogel were mimicked using sodium alginate and gum arabic with calcium ion-mediated cross-linking...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28622690/exploiting-cancer-s-phenotypic-guise-against-itself-targeting-ectopically-expressed-peptide-g-protein-coupled-receptors-for-lung-cancer-therapy
#17
REVIEW
Mahjabin Khan, Tao Huang, Cheng-Yuan Lin, Jiang Wu, Bao-Min Fan, Zhao-Xiang Bian
Lung cancer, claiming millions of lives annually, has the highest mortality rate worldwide. This advocates the development of novel cancer therapies that are highly toxic for cancer cells but negligibly toxic for healthy cells. One of the effective treatments is targeting overexpressed surface receptors of cancer cells with receptor-specific drugs. The receptors-in-focus in the current review are the G-protein coupled receptors (GPCRs), which are often overexpressed in various types of tumors. The peptide subfamily of GPCRs is the pivot of the current article owing to the high affinity and specificity to and of their cognate peptide ligands, and the proven efficacy of peptide-based therapeutics...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619003/hydroxyapatite-as-a-nanomaterial-for-advanced-tissue-engineering-and-drug-therapy
#18
Juha Tuukkanen, Miho Nakamura
Hydroxyapatite (HAp) is a complicated ceramic material that varies between the way it appears in biological systems and how it is synthesized as various calcium phosphates. HAp varies in chemical composition of substituting atoms, crystallinity, grain size and electrical polarization. HAp can form solid to macro-, micro- and nanoporous structures. Also, particulate HAp can have highly porous structure. HAp can be used as coatings for metal implants in thicknesses from hundreds of microns down to hundreds of nanometers...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28617335/zno-nano-rod-devices-for-intradermal-delivery-and-immunization
#19
Tapas R Nayak, Hao Wang, Aakansha Pant, Minrui Zheng, Hans Junginger, Wei Jiang Goh, Choon Keong Lee, Shui Zou, Sylvie Alonso, Bertrand Czarny, Gert Storm, Chorng Haur Sow, Chengkuo Lee, Giorgia Pastorin
Intradermal delivery of antigens for vaccination is a very attractive approach since the skin provides a rich network of antigen presenting cells, which aid in stimulating an immune response. Numerous intradermal techniques have been developed to enhance penetration across the skin. However, these methods are invasive and/or affect the skin integrity. Hence, our group has devised zinc oxide (ZnO) nano-rods for non-destructive drug delivery. Chemical vapour deposition was used to fabricate aligned nano-rods on ZnO pre-coated silicon chips...
June 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28614069/pegylated-lipid-bilayer-wrapped-nano-graphene-oxides-for-synergistic-co-delivery-of-doxorubicin-and-rapamycin-to-prevent-drug-resistance-in-cancers
#20
Raj Kumar Thapa, Jeong Hoon Byeon, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Nano-graphene oxide (nGO) is a carbon allotrope studied for its potential as carrier for chemotherapeutic delivery and its photoablation effects. However, interaction of nGO with blood components and the subsequent toxicities warrant a hybrid system for effective cancer drug delivery. Combination chemotherapy aids in effective cancer treatment and prevention of drug resistance. Therefore, in this study, we attempted to prepare polyethylene glycosylated (PEGylated) lipid bilayer-wrapped nGO co-loaded with doxorubicin (DOX) and rapamycin (RAPA), GOLDR, for the prevention and treatment of resistant cancers...
June 14, 2017: Nanotechnology
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