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https://www.readbyqxmd.com/read/29314049/detection-and-classification-of-citrus-green-mold-caused-by-penicillium-digitatum-using-multispectral-imaging
#1
Mahmood Reza Golzarian, Narges Ghanei Ghooshkhaneh, Mojtaba Mamarabadi
BACKGROUND: Fungal decay is a prevalent condition that mainly occurs during transportation of products to consumers (from harvest to consumption) and adversely affect post-harvest operations and sales of citrus fruit. There are a variety of methods to control pathogenic fungi including UV-assisted removal of fruit with suspected infection before storage, which is a time-taking task coupled with human health risks. Therefore, it is essential to adopt efficient dependable alternatives for early decay detection...
January 4, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29307077/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-thymic-tumors-correlation-with-grading-and-staging
#2
Angelo Iannarelli, Beatrice Sacconi, Francesca Tomei, Marco Anile, Flavia Longo, Mario Bezzi, Alessandro Napoli, Luca Saba, Michele Anzidei, Giulia D'Ovidio, Roberto Scipione, Carlo Catalano
OBJECTIVES: To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors. MATERIALS AND METHODS: Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded...
January 6, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29288891/thermal-heterogeneity-within-aqueous-materials-quantified-by-1h-nmr-spectroscopy-multiparametric-validation-in-silico-and-in-vitro
#3
Norbert W Lutz, Monique Bernard
We recently suggested a new paradigm for statistical analysis of thermal heterogeneity in (semi-)aqueous materials by 1H NMR spectroscopy, using water as a temperature probe. Here, we present a comprehensive in silico and in vitro validation that demonstrates the ability of this new technique to provide accurate quantitative parameters characterizing the statistical distribution of temperature values in a volume of (semi-)aqueous matter. First, line shape parameters of numerically simulated water 1H NMR spectra are systematically varied to study a range of mathematically well-defined temperature distributions...
December 21, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29242393/a-risk-index-and-data-display-for-process-performance-in-the-pharmaceutical-industry
#4
Bert Gunter, Daniel Coleman, Aaron Goerke, Theodoro Koulis, Jens Lamerz, Yiming Peng
We propose a new index and graphical display for quantifying and visualizing process performance in the pharmaceutical industry. These tools can provide management a comprehensive, high level overview of the process performance of a global manufacturing network suitable for risk ranking, by which is meant: identifying those processes at greatest risk of failing to meet specifications, and prioritizing resources to drive continuous process improvement. Our index, like others currently in use, compares the observed variation of CQAs -- Critical Quality Attributes -- to their specifications...
December 14, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29241700/characterization-of-the-coating-and-tablet-core-roughness-by-means-of-3d-optical-coherence-tomography
#5
Daniel Markl, Patrick Wahl, Heinz Pichler, Stephan Sacher, Johannes G Khinast
This study demonstrates the use of optical coherence tomography (OCT) to simultaneously characterize the roughness of the tablet core and coating of pharmaceutical tablets. OCT is a high resolution non-destructive and contactless imaging methodology to characterize structural properties of solid dosage forms. Besides measuring the coating thickness, it also facilitates the analysis of the tablet core and coating roughness. An automated data evaluation algorithm extracts information about coating thickness, as well as tablet core and coating roughness...
December 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29235988/optimal-transformations-leading-to-normal-distributions-of-positron-emission-tomography-standardized-uptake-values
#6
Matthew Scarpelli, Jens Eickhoff, Enrique Cuna, Scott Perlman, Robert Jeraj
The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in normal SUV distributions. This study sought to identify optimal transformations leading to normally distributed PET SUVs extracted from tumors and assess the effects of therapy on the optimal transformations...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29234822/-acute-vestibular-syndrome-clinical-examination-outperforms-mri-in-the-detection-of-central-lesions
#7
REVIEW
F Thömke
A significant number of patients who seek medical treatment in an emergency department because of vertigo or dizziness, suffer from acute vestibular syndrome. This is characterized by sustained vertigo, horizontal or horizontal rotatory jerk nystagmus, and unsteady stance and gait. In the acute situation it is crucial to differentiate patients with a peripheral vestibular disorder from those with a central disease. A number of recent studies have shown that a structured clinical examination enables a reliable differential diagnosis of central or peripheral disorders...
December 12, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29221318/lung-densitometry-why-how-and-when
#8
REVIEW
Mario Mascalchi, Gianna Camiciottoli, Stefano Diciotti
Lung densitometry assesses with computed tomography (CT) the X-ray attenuation of the pulmonary tissue which reflects both the degree of inflation and the structural lung abnormalities implying decreased attenuation, as in emphysema and cystic diseases, or increased attenuation, as in fibrosis. Five reasons justify replacement with lung densitometry of semi-quantitative visual scales used to measure extent and severity of diffuse lung diseases: (I) improved reproducibility; (II) complete vs. discrete assessment of the lung tissue; (III) shorter computation times; (IV) better correlation with pathology quantification of pulmonary emphysema; (V) better or equal correlation with pulmonary function tests (PFT)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29208731/misleading-signs-in-acute-vertigo
#9
Sean Lance, Stuart Scott Mossman
The acute vestibular syndrome is common and usually has a benign cause. Sometimes, however, even experienced neurologists can find it difficult to determine the cause clinically. Furthermore, neuroimaging is known to be insensitive.We describe two cases of acute vestibular syndrome where conflicting clinical findings contributed to a delay in making the correct diagnosis. The first patient with symptomatic vertigo had signs consistent with horizontal benign paroxysmal positional vertigo but also had an abnormal horizontal head impulse test, superficially suggesting acute vestibular neuritis but later accounted for by the finding of a vestibular schwannoma (acoustic neuroma)...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29195318/experimental-characterization-of-the-transition-to-coherence-collapse-in-a-semiconductor-laser-with-optical-feedback
#10
M Panozzo, C Quintero-Quiroz, J Tiana-Alsina, M C Torrent, C Masoller
Semiconductor lasers with time-delayed optical feedback display a wide range of dynamical regimes, which have found various practical applications. They also provide excellent testbeds for data analysis tools for characterizing complex signals. Recently, several of us have analyzed experimental intensity time-traces and quantitatively identified the onset of different dynamical regimes, as the laser current increases. Specifically, we identified the onset of low-frequency fluctuations (LFFs), where the laser intensity displays abrupt dropouts, and the onset of coherence collapse (CC), where the intensity fluctuations are highly irregular...
November 2017: Chaos
https://www.readbyqxmd.com/read/29193455/the-parkinson-s-disease-composite-scale-results-of-the-first-validation-study
#11
Fabrizio Stocchi, Fabiana G Radicati, K Ray Chaudhuri, Anders Johansson, Chandrasekhara Padmakumar, Cristian Falup-Pecurariu, Pablo Martinez Martin
OBJECTIVE: Validate the Parkinson's disease (PD) composite scale (PDCS). METHODS: The study included One hundred ninety four PD patients in five countries. Investigators completed the following scales: PDCS, MDS-UPDRS, PDSS-2, MoCA, WOK-19, SEND-PD and CISI-PD. For test-retest analysis, a second administration of the PDCS was carried out in 61 stable patients (as per the CISI-PD) in 7 to 14 days after the first evaluation. The PDCS is a novel scale for PD with a total of 17 items divided in 4 domains: motor, non-motor, treatment complication and disability...
November 29, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29175658/%C3%B0-onformational-study-of-persulfated-propyl-glucuronide
#12
Alexey G Gerbst, Dmitry Z Vinnitsky, Andrey S Dmitrenok, Nadezhda E Ustyuzhanina, Nikolay E Nifantiev
Glucuronic acid is an important constituting block of biologically active glycosaminoglycans where it can be present in non-sulfated, mono-sulfated and di-sulfated forms. Despite that some investigators reported previously that the exhaustively sulfated glucuronic acid moiety was characterized with unusual 1H-1H coupling constants and some times chemical shifts, these were just qualitative studies in which their authors suggested that the mentioned deviations in NMR spectra might mean complete inversion of the normal D-pyranoside chair conformation 4C1 to 1C4...
November 17, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29166162/stochastic-evolutionary-demography-under-a-fluctuating-optimum-phenotype
#13
Luis-Miguel Chevin, Olivier Cotto, Jaime Ashander
Many natural populations exhibit temporal fluctuations in abundance that are consistent with external forcing by a randomly changing environment. As fitness emerges from an interaction between the phenotype and the environment, such demographic fluctuations probably include a substantial contribution from fluctuating phenotypic selection. We study the stochastic population dynamics of a population exposed to random (plus possibly directional) changes in the optimum phenotype for a quantitative trait that evolves in response to this moving optimum...
December 2017: American Naturalist
https://www.readbyqxmd.com/read/29164382/ct-texture-features-of-liver-parenchyma-for-predicting-development-of-metastatic-disease-and-overall-survival-in-patients-with-colorectal-cancer
#14
Scott J Lee, Ryan Zea, David H Kim, Meghan G Lubner, Dustin A Deming, Perry J Pickhardt
OBJECTIVES: To determine if identifiable hepatic textural features are present at abdominal CT in patients with colorectal cancer (CRC) prior to the development of CT-detectable hepatic metastases. METHODS: Four filtration-histogram texture features (standard deviation, skewness, entropy and kurtosis) were extracted from the liver parenchyma on portal venous phase CT images at staging and post-treatment surveillance. Surveillance scans corresponded to the last scan prior to the development of CT-detectable CRC liver metastases in 29 patients (median time interval, 6 months), and these were compared with interval-matched surveillance scans in 60 CRC patients who did not develop liver metastases...
November 21, 2017: European Radiology
https://www.readbyqxmd.com/read/29163005/in-vivo-imaging-of-tau-pathology-using-magnetic-resonance-imaging-textural-analysis
#15
Niall Colgan, Balaji Ganeshan, Ian F Harrison, Ozama Ismail, Holly E Holmes, Jack A Wells, Nick M Powell, James M O'Callaghan, Michael J O'Neill, Tracey K Murray, Zeshan Ahmed, Emily C Collins, Ross A Johnson, Ashley Groves, Mark F Lythgoe
Background: Non-invasive characterization of the pathological features of Alzheimer's disease (AD) could enhance patient management and the development of therapeutic strategies. Magnetic resonance imaging texture analysis (MRTA) has been used previously to extract texture descriptors from structural clinical scans in AD to determine cerebral tissue heterogeneity. In this study, we examined the potential of MRTA to specifically identify tau pathology in an AD mouse model and compared the MRTA metrics to histological measures of tau burden...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29141096/quantifying-publication-bias-in-meta-analysis
#16
Lifeng Lin, Haitao Chu
Publication bias is a serious problem in systematic reviews and meta-analyses, which can affect the validity and generalization of conclusions. Currently, approaches to dealing with publication bias can be distinguished into two classes: selection models and funnel-plot-based methods. Selection models use weight functions to adjust the overall effect size estimate and are usually employed as sensitivity analyses to assess the potential impact of publication bias. Funnel-plot-based methods include visual examination of a funnel plot, regression and rank tests, and the nonparametric trim and fill method...
November 15, 2017: Biometrics
https://www.readbyqxmd.com/read/29108125/robust-fit-of-bayesian-mixed-effects-regression-models-with-application-to-colony-forming-unit-count-in-tuberculosis-research
#17
Divan Aristo Burger, Robert Schall
Early bactericidal activity of tuberculosis drugs is conventionally assessed using statistical regression modeling of colony forming unit (CFU) counts over time. Typically, most CFU counts deviate little from the regression curve, but gross outliers due to erroneous sputum sampling are occasionally present and can markedly influence estimates of the rate of change in CFU count, which is the parameter of interest. A recently introduced Bayesian nonlinear mixed effects regression model was adapted to offer a robust approach that accommodates both outliers and potential skewness in the data...
November 6, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29090043/distribution-of-different-sized-ocular-surface-vessels-in-diabetics-and-normal-individuals
#18
Touka Banaee, Hamidreza Pourreza, Hassan Doosti, Mojtaba Abrishami, Asieh Ehsaei, Mohsen Basiry, Reza Pourreza
PURPOSE: To compare the distribution of different sized vessels using digital photographs of the ocular surface of diabetic and normal individuals. METHODS: In this cross-sectional study, red-free conjunctival photographs of diabetic and normal individuals, aged 30-60 years, were taken under defined conditions and analyzed using a Radon transform-based algorithm for vascular segmentation. The image areas occupied by vessels (AOV) of different diameters were calculated...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29089218/-how-to-manage-vertigo-in-adult
#19
Hella Vuong Chaney, Dominique Rohmer, Anne Charpiot
The interrogation and the clinical examination are critical in the research of vertigo etiology. In the context of vertigo, the vital emergencies are of neurological and vascular origins. It is therefore necessary to be able to identify them quickly and simply. Vertigo is a symptom to relieve and the cause is to be diagnosed. Careful questioning combined with neurological examination, nystagmus study, Halmagyi test and skew deviation search are more reliable than imaging in the first 48hours to detect a stroke...
October 28, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29065039/opioid-prescribing-practices-by-orthopaedic-trauma-surgeons-after-isolated-femur-fractures
#20
Basem Attum, Andres Buitrago Rodriguez, Nichelle Harrison, Adam Evans, William Obremskey, Manish Sethi, Alex Jahangir
OBJECTIVE: The purpose of this retrospective study was to identify opioid prescribing practices, determine the number of morphine milliequivalents (MMEs) prescribed by orthopaedic/non-orthopaedic members to narcotic naive and previously exposed patients and provide narcotic prescribing recommendations. METHODS: Patients over 18 years old with an isolated femur fracture sustained between 2013 and 2015 were identified using the CPT code 27506. Prescribing information was obtained from the State Controlled Substance Monitoring Database (CSMD)...
October 14, 2017: Journal of Orthopaedic Trauma
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