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Skew deviation

Vinit Baliyan, Hamed Kordbacheh, Bimal Parameswaran, Balaji Ganeshan, Dushyant Sahani, Avinash Kambadakone
PURPOSE: To study the impact of keV levels of virtual monoenergetic images generated from rapid kVp-switching dual-energy CT (rsDECT) on CT texture analysis (CTTA). METHODS: This study included 30 consecutive patients (59.3 ± 12 years; range 34-77 years; 17M:13F) who underwent portal venous phase abdominal CT on a rsDECT scanner. Axial 5-mm monoenergetic images at 5 energy levels (40/50/60/70/80 keV) were created and CTTA of liver was performed. CTTA comprised a filtration-histogram technique with different spatial scale filter (SSF) values (0-6)...
March 14, 2018: Abdominal Radiology
S Eh Shirmovsky, D V Shulga
The paper investigates microtubules lattice properties taking into consideration elastic, dipole-dipole interaction of tubulins and viscosity. A microtubule is modeled as a system of bound tubulins, forming a skewed hexagonal two-dimensional lattice. Wave frequencies and group velocities have been calculated. Calculations have been performed for various directions of wave front propagation: helix, along the protofilament, and anti-helix. Three different wave polarization directions have been considered. It has been shown that the direction of the wave polarization influences the frequency and wave group velocity values in the lattice considerably...
March 8, 2018: Bio Systems
Bahram Javidi, Adam Markman, Siddharth Rawat
We investigate the use of compact, lensless, single random phase encoding (SRPE) and double random phase encoding (DRPE) systems for automatic cell identification when multiple cells, either of the same or mixed classes, are in the field of view. A microscope glass slide containing the sample is inputted into the single or double random phase encoding system, which is then illuminated by a coherent or partially coherent light source generating a unique opto-biological signature (OBS) that is captured by an image sensor...
March 1, 2018: Applied Optics
Christopher J Weir, Isabella Butcher, Valentina Assi, Stephanie C Lewis, Gordon D Murray, Peter Langhorne, Marian C Brady
BACKGROUND: Rigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or variability often goes unreported. While full reporting of original trial data is the ideal, we sought to identify methods for handling unreported mean or variability summary statistics in meta-analysis. METHODS: We undertook two systematic literature reviews to identify methodological approaches used to deal with missing mean or variability summary statistics...
March 7, 2018: BMC Medical Research Methodology
Nese Celebisoy
HINTS battery involving head impulse test (HIT), nystagmus, and test of skew is the critical bedside examination to differentiate acute unilateral peripheral vestibulopathy from posterior circulation stroke (PCS) in acute vestibular syndrome (AVS). The highest sensitivity component of the battery has been reported to be the horizontal HIT, whereas skew deviation is defined as the most specific but non-sensitive sign for PCS. Video-oculography-based HIT (vHIT) may have an additional power in making the differentiation...
March 5, 2018: Journal of Neurology
Anastasia Oikonomou, Farzad Khalvati, Pascal N Tyrrell, Masoom A Haider, Usman Tarique, Laura Jimenez-Juan, Michael C Tjong, Ian Poon, Armin Eilaghi, Lisa Ehrlich, Patrick Cheung
We sought to quantify contribution of radiomics and SUVmax at PET/CT to predict clinical outcome in lung cancer patients treated with stereotactic body radiotherapy (SBRT). 150 patients with 172 lung cancers, who underwent SBRT were retrospectively included. Radiomics were applied on PET/CT. Principal components (PC) for 42 CT and PET-derived features were examined to determine which ones accounted for most of variability. Survival analysis quantified ability of radiomics and SUVmax to predict outcome. PCs including homogeneity, size, maximum intensity, mean and median gray level, standard deviation, entropy, kurtosis, skewness, morphology and asymmetry were included in prediction models for regional control (RC) [PC4-HR:0...
March 5, 2018: Scientific Reports
Justin A Charles, Peder Ahnfeldt-Mollerup, Jens Søndergaard, Troels Kristensen
Background : Previous studies have demonstrated that high levels of physician empathy may be correlated with improved patient health outcomes and high physician job satisfaction. Knowledge about variation in empathy and related general practitioner (GP) characteristics may allow for a more informed approach to improve empathy among GPs. Objective : Our objective is to measure and analyze variation in physician empathy and its association with GP demographic, professional, and job satisfaction characteristics...
March 2, 2018: International Journal of Environmental Research and Public Health
Rafał Brygoła, Sławomir Sęk, Maciej Sokołowski, Marek Kowalczyk-Hernández, Jacek Pniewski
In the paper the results of AFM surface profile measurements of seven new long-wear contact lenses (CL) available in Poland are presented. Calculated statistical roughness parameters are shown, namely standard deviation (RMS), mean roughness, maximum difference between peak and valley, skewness, and kurtosis. It is demonstrated that CLs manufactured using recent methods, such as two-stage polimerisation or extending silicon chains exhibit small RMS, less than 10 nm, in comparison with older generation CLs which maintains RMS on the level of tens of nanometers...
February 15, 2018: Colloids and Surfaces. B, Biointerfaces
J G Cohen, E Reymond, M Medici, M Lederlin, S Lantuejoul, F Laurent, A C Toffart, A Moreau-Gaudry, A Jankowski, G R Ferretti
PURPOSE: The purpose of this study was to evaluate the usefulness of computed tomography-texture analysis (CTTA) in differentiating between in-situ and minimally-invasive from invasive adenocarcinomas in subsolid lung nodules (SSLNs). MATERIAL AND METHODS: Two radiologists retrospectively reviewed 49 SSLNs in 44 patients. There were 27 men and 17 women with a mean age of 63±7 (SD) years (range: 47-78years). For each SSLN, type (pure ground-glass or part-solid) was assessed by consensus and CTTA was conducted independently by each observer using a filtration-histogram technique...
February 21, 2018: Diagnostic and Interventional Imaging
João Lemos, Adnan Subei, Mário Sousa, César Nunes, Luís Cunha, Christopher Glisson, Eric Eggenberger
Importance: Accurate clinical differentiation between skew deviation and fourth nerve palsy (4NP) is critical in the acute and subacute settings. Objective: To determine the sensitivity and specificity of the upright-supine test to detect vertical misalignment changes using different head positions for the diagnosis of acute or subacute skew deviation vs 4NP. Design, Setting, and Participants: This multicenter study enrolled consecutive patients from Coimbra University Hospital Centre, Coimbra, Portugal, and Michigan State University, Lansing, within 2 months of presenting with vertical diplopia and diagnosed as having skew deviation or acquired unilateral 4NP...
February 15, 2018: JAMA Ophthalmology
A Mavrodi, V Aletras, A Spanou, D Niakas
BACKGROUND AND OBJECTIVE: Contingent valuation is widely used to determine individuals' willingness to pay (WTP) for a health gain. Our study aimed to elicit an empirical estimate of the monetary value of a quality-adjusted life year (QALY) in a Greek outpatient setting in times of economic austerity and assess the impact of patients' characteristics on their valuations. METHODS: We used a questionnaire as a survey tool to determine the maximum WTP for a health gain of a hypothetical therapy and to evaluate patients' health-related quality of life (EuroQoL-5D-3L) and demographic and socioeconomic characteristics...
December 2017: PharmacoEconomics Open
Tameto Naoi, Mitsuya Morita, Tadataka Kawakami, Shigeru Fujimoto
A 67-year-old man with hypertension and type 2 diabetes mellitus was admitted to our hospital because of left hearing loss and vertical diplopia. A neurological examination showed ocular torsion, skew deviation, and sensorineural hearing loss in the left ear. Brainstem and cerebellar neurological signs were not observed. Left middle cerebellar peduncle infarction was evident on magnetic resonance imaging. He was treated with antiplatelet, however, the infarct progressed after this administration. Ocular tilt reaction (OTR) involves the triad of ocular torsion, skew deviation, and head tilt...
February 9, 2018: Internal Medicine
Jisook Yi, Young Han Lee, Sang Kyum Kim, Seung Hyun Kim, Ho-Taek Song, Kyoo-Ho Shin, Jin-Suck Suh
BACKGROUND: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. METHODS: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Shamik Gupta, Jorge C Leitão, Eduardo G Altmann
We introduce and implement an importance-sampling Monte Carlo algorithm to study systems of globally coupled oscillators. Our computational method efficiently obtains estimates of the tails of the distribution of various measures of dynamical trajectories corresponding to states occurring with (exponentially) small probabilities. We demonstrate the general validity of our results by applying the method to two contrasting cases: the driven-dissipative Kuramoto model, a paradigm in the study of spontaneous synchronization; and the conservative Hamiltonian mean-field model, a prototypical system of long-range interactions...
July 2017: Physical Review. E
Samuel M Dresner, Nathan H Kung, Joel R Palko, Jonathan L McJunkin, Joel A Goebel, Gregory P Van Stavern
Skew deviation is a rare side effect of intratympanic gentamicin injection for intractable Meniere's disease. When the skew deviation is accompanied by pathologic head tilt and ocular torsion, the result is an ocular tilt reaction (OTR). The authors report the case of a 56-year-old man with refractory Meniere's disease who developed binocular vertical diplopia following intratympanic gentamicin injection and was found to have skew deviation and a partial ocular tilt reaction. The authors also review the reported cases of skew deviation following intratympanic gentamicin and confirm this phenomenon, which has only rarely been reported in the literature...
October 2017: Neuro-ophthalmology
Mahmood Reza Golzarian, Narges Ghanei Ghooshkhaneh, Mojtaba Mamarabadi
BACKGROUND: Fungal decay is a prevalent condition that mainly occurs during transportation of products to consumers (from harvest to consumption) and adversely affect post-harvest operations and sales of citrus fruit. There are a variety of methods to control pathogenic fungi including UV-assisted removal of fruit with suspected infection before storage, which is a time-taking task coupled with human health risks. Therefore, it is essential to adopt efficient dependable alternatives for early decay detection...
January 4, 2018: Journal of the Science of Food and Agriculture
Angelo Iannarelli, Beatrice Sacconi, Francesca Tomei, Marco Anile, Flavia Longo, Mario Bezzi, Alessandro Napoli, Luca Saba, Michele Anzidei, Giulia D'Ovidio, Roberto Scipione, Carlo Catalano
OBJECTIVES: To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors. MATERIALS AND METHODS: Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded...
January 6, 2018: La Radiologia Medica
Norbert W Lutz, Monique Bernard
We recently suggested a new paradigm for statistical analysis of thermal heterogeneity in (semi-)aqueous materials by 1H NMR spectroscopy, using water as a temperature probe. Here, we present a comprehensive in silico and in vitro validation that demonstrates the ability of this new technique to provide accurate quantitative parameters characterizing the statistical distribution of temperature values in a volume of (semi-)aqueous matter. First, line shape parameters of numerically simulated water 1H NMR spectra are systematically varied to study a range of mathematically well-defined temperature distributions...
December 21, 2017: Journal of Magnetic Resonance
Bert Gunter, Daniel Coleman, Aaron Goerke, Theodoro Koulis, Jens Lamerz, Yiming Peng
We propose a new index and graphical display for quantifying and visualizing process performance in the pharmaceutical industry. These tools can provide management a comprehensive, high level overview of the process performance of a global manufacturing network suitable for risk ranking, by which is meant: identifying those processes at greatest risk of failing to meet specifications, and prioritizing resources to drive continuous process improvement. Our index, like others currently in use, compares the observed variation of CQAs -- Critical Quality Attributes -- to their specifications...
December 14, 2017: PDA Journal of Pharmaceutical Science and Technology
Daniel Markl, Patrick Wahl, Heinz Pichler, Stephan Sacher, Johannes G Khinast
This study demonstrates the use of optical coherence tomography (OCT) to simultaneously characterize the roughness of the tablet core and coating of pharmaceutical tablets. OCT is a high resolution non-destructive and contactless imaging methodology to characterize structural properties of solid dosage forms. Besides measuring the coating thickness, it also facilitates the analysis of the tablet core and coating roughness. An automated data evaluation algorithm extracts information about coating thickness, as well as tablet core and coating roughness...
December 11, 2017: International Journal of Pharmaceutics
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